CD150

Summary

Gene Symbol: CD150
Description: signaling lymphocytic activation molecule family member 1
Alias: CD150, CDw150, SLAM, signaling lymphocytic activation molecule, IPO-3, SLAM family member 1
Species: human
Products:     CD150

Top Publications

  1. Tatsuo H, Ono N, Tanaka K, Yanagi Y. SLAM (CDw150) is a cellular receptor for measles virus. Nature. 2000;406:893-7 pubmed
    ..Here we show that human SLAM (signalling lymphocyte-activation molecule; also known as CDw150), a recently discovered membrane glycoprotein expressed on some T and B cells, is a cellular receptor for measles ..
  2. Kruse M, Meinl E, Henning G, Kuhnt C, Berchtold S, Berger T, et al. Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta. J Immunol. 2001;167:1989-95 pubmed
    Signaling lymphocyte activation molecule (SLAM), a 70-kDa costimulatory molecule that mediates CD28-independent proliferation of T cells and IFN-gamma production, has been identified on human T cells, immature thymocytes, and a subset of ..
  3. Cocks B, Chang C, Carballido J, Yssel H, de Vries J, Aversa G. A novel receptor involved in T-cell activation. Nature. 1995;376:260-3 pubmed
    ..Here we describe a novel glycoprotein, of relative molecular mass 70,000 (M(r) 70K), designated SLAM, that belongs to the immunoglobulin gene superfamily, which is involved in T-cell stimulation...
  4. Punnonen J, Cocks B, Carballido J, Bennett B, Peterson D, Aversa G, et al. Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes. J Exp Med. 1997;185:993-1004 pubmed
    In this study it is shown that both membrane-bound and soluble forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B cells...
  5. Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998;395:462-9 pubmed
    ..The protein SLAM (also known as CDw150), which is present on the surface of B and T cells, forms such a receptor-ligand pair as it is a self-ligand...
  6. Bleharski J, Niazi K, Sieling P, Cheng G, Modlin R. Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines. J Immunol. 2001;167:3174-81 pubmed
    ..In this study, we present evidence that signaling lymphocytic activation molecule (SLAM), a molecule first identified in activated T and B cells, is strongly up-regulated in DC ..
  7. Mikhalap S, Shlapatska L, Yurchenko O, Yurchenko M, Berdova G, Nichols K, et al. The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. Blood. 2004;104:4063-70 pubmed
    The CD150 receptor is expressed on activated T and B lymphocytes, dendritic cells, and monocytes...
  8. Tahara M, Takeda M, Shirogane Y, Hashiguchi T, Ohno S, Yanagi Y. Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin. J Virol. 2008;82:4630-7 pubmed publisher
    ..The signaling lymphocyte activation molecule (SLAM), also called CD150, is a cellular receptor for measles virus (MV), presumably accounting for its tropism for immune cells and its ..
  9. Ferreira C, Frenzke M, Leonard V, Welstead G, Richardson C, Cattaneo R. Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150). J Virol. 2010;84:3033-42 pubmed publisher
    ..we took advantage of mice expressing the MV receptor human signaling lymphocyte activation molecule (SLAM, CD150) with human-like tissue specificity...

More Information

Publications114 found, 100 shown here

  1. Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, et al. Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM. Nat Struct Mol Biol. 2011;18:135-41 pubmed publisher
    ..and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor...
  2. Mühlebach M, Mateo M, Sinn P, Prüfer S, Uhlig K, Leonard V, et al. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature. 2011;480:530-3 pubmed publisher
    ..cells of the airways using signalling lymphocytic activation molecule family member 1 (SLAMF1; also called CD150) as a receptor...
  3. Ma C, Wang N, Detre C, Wang G, O Keeffe M, Terhorst C. Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J Biol Chem. 2012;287:18359-65 pubmed publisher
  4. Murabayashi N, Kurita Taniguchi M, Ayata M, Matsumoto M, Ogura H, Seya T. Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification. Microbes Infect. 2002;4:785-94 pubmed
    Human CD46 (membrane cofactor protein, or MCP) and CDw150 (signaling lymphocyte activation molecule, or SLAM) serve as receptors for measles virus (MV), which induces marked host immune suppression...
  5. Takeda M, Tahara M, Hashiguchi T, Sato T, Jinnouchi F, Ueki S, et al. A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via a SLAM- and CD46-independent mechanism. J Virol. 2007;81:12091-6 pubmed
    ..in lymphoid organs throughout the body and produces syncytia by using signaling lymphocyte activation molecule (SLAM) as a receptor. MV also spreads in SLAM-negative epithelial tissues by unknown mechanisms...
  6. De Swart R, Ludlow M, de Witte L, Yanagi Y, van Amerongen G, McQuaid S, et al. Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques. PLoS Pathog. 2007;3:e178 pubmed
    ..However, neither of these cell types express signaling lymphocyte activation molecule (CD150), which has been identified as the receptor for wild-type MV...
  7. Zaidi S, Hameed A, Suleman Rana M, Alam M, Umair M, Aamir U, et al. Identification of measles virus genotype B3 associated with outbreaks in Islamabad, Pakistan, 2013-2015. J Infect Public Health. 2018;11:540-545 pubmed publisher
    ..antibodies using enzyme-linked immunosorbent assay (ELISA) while throat swabs were used for the isolation (Vero/SLAM cell line) and subsequent characterization and phylogenetic analysis of measles strains...
  8. Schneider Schaulies J, Schneider Schaulies S. Sphingolipids in viral infection. Biol Chem. 2015;396:585-95 pubmed publisher
    ..platforms and endocytosis; or measles virus (MV), which induces the surface expression of its own receptor CD150 via activation of sphingomyelinases (SMases)...
  9. Takenaka A, Sato H, Ikeda F, Yoneda M, Kai C. Infectious Progression of Canine Distemper Virus from Circulating Cerebrospinal Fluid into the Central Nervous System. J Virol. 2016;90:9285-92 pubmed publisher
    ..These cells lack the CDV receptors that have been identified to date (SLAM and nectin-4), indicating that the H protein defines infectivity in various cell lines...
  10. Marsh R, Bleesing J, Chandrakasan S, Jordan M, Davies S, Filipovich A. Reduced-intensity conditioning hematopoietic cell transplantation is an effective treatment for patients with SLAM-associated protein deficiency/X-linked lymphoproliferative disease type 1. Biol Blood Marrow Transplant. 2014;20:1641-5 pubmed publisher
    ..RIC HCT with alemtuzumab, fludarabine, and melphalan is an effective treatment for patients with XLP1, offering good survival rates regardless of prior disease manifestations, including HLH. ..
  11. Mathieu C, Huey D, Jurgens E, Welsch J, DeVito I, Talekar A, et al. Prevention of measles virus infection by intranasal delivery of fusion inhibitor peptides. J Virol. 2015;89:1143-55 pubmed publisher
    ..is required to inhibit F-mediated fusion when H is engaged to its nectin-4 receptor than when H is engaged to its CD150 receptor...
  12. Laksono B, de Vries R, McQuaid S, Duprex W, De Swart R. Measles Virus Host Invasion and Pathogenesis. Viruses. 2016;8: pubmed publisher
    ..Identification of CD150 and nectin-4 as cellular receptors for measles virus has led to new perspectives on tropism and pathogenesis...
  13. Aref S, Bailey K, Fielding A. Measles to the Rescue: A Review of Oncolytic Measles Virus. Viruses. 2016;8: pubmed
    ..enter transformed cells and there is increasing awareness of the importance of nectin-4 and signaling lymphocytic activation molecule (SLAM) in oncolysis...
  14. Li S, Qian X, Yuan Z, Sun X, Li C, Tang X, et al. Molecular epidemiology of measles virus infection in Shanghai in 2000-2012: the first appearance of genotype D8. Braz J Infect Dis. 2014;18:581-90 pubmed publisher
    ..Measles virus was isolated using Vero-SLAM cells (African green monkey kidney cells/lymphoid signal activating factor-transfected African green monkey kidney ..
  15. Sundaramoorthy P, Wang Q, Zheng Z, Jiao Y, Chen B, Doan P, et al. Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice. Stem Cell Res Ther. 2017;8:263 pubmed publisher
    ..cellularity, and HSC population as measured by c-Kit+Sca-1+Lin- (KSL) cells, SLAM?+?KSL cells and CFUs...
  16. Ader Ebert N, Khosravi M, Herren M, Avila M, Alves L, Bringolf F, et al. Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process. PLoS Pathog. 2015;11:e1004880 pubmed publisher
    ..H, as well as standard and engineered bioactive stalk-elongated CDV H-constructs treated with cells expressing the SLAM receptor, was enhanced...
  17. Delpeut S, Sisson G, Black K, Richardson C. Measles Virus Enters Breast and Colon Cancer Cell Lines through a PVRL4-Mediated Macropinocytosis Pathway. J Virol. 2017;91: pubmed publisher
    ..The contribution of each endocytic pathway has been examined in cells that express the MeV receptors SLAM (signaling lymphocyte-activating molecule) and PVRL4 (poliovirus receptor-like 4) (nectin-4)...
  18. Al Rubaie A, Wise A, Sozo F, De Matteo R, Samuel C, Harding R, et al. The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice. Respir Res. 2018;19:114 pubmed publisher
    ..Not only did our cell-based therapy using hMSC induce structural repair, it limited the progression of pulmonary fibrosis. ..
  19. Diebold M, Sievers C, Bantug G, Sanderson N, Kappos L, Kuhle J, et al. Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis. J Autoimmun. 2018;86:39-50 pubmed publisher
    ..Consequently, the expression of co-stimulatory molecules like CD40 and CD150 was decreased in antigen presenting cells both in-vitro and ex-vivo...
  20. van der Heide V, Möhnle P, Rink J, Briegel J, Kreth S. Down-regulation of MicroRNA-31 in CD4+ T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing. Anesthesiology. 2016;124:908-22 pubmed publisher
    ..Interferon-γ, however, was influenced via control of signaling lymphocytic activation molecule (SLAM)-associated protein, an essential adaptor molecule of immunomodulatory SLAM receptor ..
  21. Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, et al. Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome. BMC Biotechnol. 2015;15:58 pubmed publisher
    ..PEG) has partly solved this drawback, whereas the tropism of MV fusogenic proteins is restricted to human CD46- or SLAM-positive cells...
  22. You L, Li L, Zou J, Yan K, Belle J, Nijnik A, et al. BRPF1 is essential for development of fetal hematopoietic stem cells. J Clin Invest. 2016;126:3247-62 pubmed publisher
    ..These results identify an essential role of the multivalent chromatin regulator BRPF1 in definitive hematopoiesis and illuminate a potentially new avenue for studying epigenetic networks that govern HSC ontogeny. ..
  23. Yoon H, Ko Y. LMP1+SLAMF1high cells are associated with drug resistance in Epstein-Barr virus-positive Farage cells. Oncotarget. 2017;8:24621-24634 pubmed publisher
    ..We suggest that LMP1high cells are responsible for the poor drug response of EBV+ DLBCL and that perturbation of the NF-κB and STAT signaling pathways increases toxicity in these cells. ..
  24. Liu W, Liu B. [Establishment of Trace Amount Bone Marrow Hematopoietic Stem Cells of Adult Mouse Transplantation System]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26:1180-1185 pubmed publisher
    ..marrow cells of GFP adult mouse were seperated by using marker combination ESLAM (CD45+CD201+CD150+CD48-) The goal cell population acquired by flow cytometry sorting were injected into ..
  25. Richardson P, Jagannath S, Moreau P, Jakubowiak A, Raab M, Facon T, et al. Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: final phase 2 results from the randomised, open-label, phase 1b-2 dose-escalation study. Lancet Haematol. 2015;2:e516-27 pubmed publisher
    Elotuzumab, an immunostimulatory monoclonal antibody targeting signalling lymphocytic activation molecule (SLAM) family member 7 (SLAMF7), selectively kills SLAMF7-expressing myeloma cells through direct activation and engagement of the ..
  26. Palomer A, Ridao P, Ribas D. Multibeam 3D Underwater SLAM with Probabilistic Registration. Sensors (Basel). 2016;16: pubmed publisher
    This paper describes a pose-based underwater 3D Simultaneous Localization and Mapping (SLAM) using a multibeam echosounder to produce high consistency underwater maps...
  27. Szade K, Bukowska Strakova K, Zukowska M, Jozkowicz A, Dulak J. Analysis of Cell Cycle Status of Murine Hematopoietic Stem Cells. Methods Mol Biol. 2016;1516:91-99 pubmed publisher
    ..Here, we presented our simple strategy to analyze cell cycle of strictly defined LKS CD48(-)CD150(+)CD34(-) HSC, together with Ki67 and DAPI staining by flow cytometry.
  28. Chen S, Cai C, Li Z, Liu G, Wang Y, Blonska M, et al. Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity. J Exp Med. 2017;214:475-489 pubmed publisher
    b>Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) mutations in X-linked lymphoproliferative disease (XLP) lead to defective NKT cell development and impaired humoral immunity...
  29. Baglaenko Y, Cruz Tleugabulova M, Gracey E, Talaei N, Manion K, Chang N, et al. Invariant NKT Cell Activation Is Potentiated by Homotypic trans-Ly108 Interactions. J Immunol. 2017;198:3949-3962 pubmed publisher
    ..we show that C57BL/6 mice containing the New Zealand Black Slam locus have profound alterations in Ly108, CD150, and Ly9 expression that is associated with iNKT cell hyporesponsiveness...
  30. Bouwmeester O, van de Pol D, Kuijer P, Planken R, Terpstra A, Pannekoek Hekman M, et al. Diagnostic properties of the SPIQuestionnaire to detect Posterior Circumflex Humeral Artery Disease in elite volleyball players: a cross-sectional study. Eur J Radiol. 2018;98:20-24 pubmed publisher
    ..and single highest Dutch volleyball division and by elite beach volleyball players participating in the 2014 Grand Slam Beach Tournament The Hague (GSBTH)...
  31. Bydlinski N, Harreither E, Baumann M. The 6th International Conference on Analysis of Microbial Cells at the Single Cell Level, Retz, Austria, 19-22 July 2015. N Biotechnol. 2016;: pubmed publisher
    ..In addition, a high speed poster slam session contributed to the lively discussions and exchange of expertise among academic and industrial researchers.
  32. Suzuki Y. Predicting receptor functionality of signaling lymphocyte activation molecule for measles virus hemagglutinin by docking simulation. Microbiol Immunol. 2017;61:185-189 pubmed publisher
    ..virus hemagglutinin (MV-H) and immunoglobulin-like variable domain of signaling lymphocyte activation molecule (SLAM-V)...
  33. Li C, Iosef C, Jia C, Han V, Li S. Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. J Biol Chem. 2003;278:3852-9 pubmed
    ..One postulates that it acts as an inhibitor of interactions between the phosphatase SHP-2 and the immune receptor SLAM. The other suggests that it functions as an adaptor to promote the recruitment of a kinase, FynT, to SLAM...
  34. Wu X, Liu F, Li L, Zou Y, Liu S, Wang Z. Major mutation events in structural genes of peste des petits ruminants virus through serial passages in vitro. Virus Genes. 2016;52:422-7 pubmed publisher
    ..1). To date, this isolate has been virulently attenuated by more than 90 serial passages in Vero-Dog-SLAM cells at our laboratory...
  35. Michel M, Lenoir C, Massot B, Diem S, Pasquier B, Sawa S, et al. SLAM-associated protein favors the development of iNKT2 over iNKT17 cells. Eur J Immunol. 2016;46:2162-74 pubmed publisher
    ..Signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) is essential for early stages of iNKT cell development, but its role during terminal ..
  36. Ajnakina O, Lally J, Di Forti M, Kolliakou A, Gardner Sood P, Lopez Morinigo J, et al. Patterns of illness and care over the 5 years following onset of psychosis in different ethnic groups; the GAP-5 study. Soc Psychiatry Psychiatr Epidemiol. 2017;52:1101-1111 pubmed publisher
    ..Using the electronic psychiatric clinical notes in the South London and Maudsley NHS Foundation Trust (SLaM), extensive information was collected on three domains-clinical, social, and service use...
  37. He B, Liu Y, Dong D, Shen Y, Yan T, Nian R. Simultaneous Localization and Mapping with Iterative Sparse Extended Information Filter for Autonomous Vehicles. Sensors (Basel). 2015;15:19852-79 pubmed publisher
    ..sparse extended information filter (ISEIF) was proposed to solve the simultaneous localization and mapping problem (SLAM), which is very crucial for autonomous vehicles...
  38. Miles A, Pope J. A comparison of rheumatoid arthritis and systemic lupus erythematosus trial design: a commentary on ways to improve the number of positive trials in SLE. Clin Exp Rheumatol. 2015;33:671-80 pubmed
    ..All RA RCTs used either a partial or continuous measure of improvement. SLE RCTs used SLEDAI, BILAG, SLAM, SRI and BICLA. RA trials were larger (543 vs. 376 participants)...
  39. Khosravi M, Bringolf F, Röthlisberger S, Bieringer M, Schneider Schaulies J, Zurbriggen A, et al. Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM. J Virol. 2016;90:1622-37 pubmed publisher
    ..virus (CDV) possess tetrameric attachment proteins (H) and trimeric fusion proteins, which cooperate with either SLAM or nectin 4 receptors to trigger membrane fusion for cell entry...
  40. Coppejans H, Myburgh H. A Primer on Autonomous Aerial Vehicle Design. Sensors (Basel). 2015;15:30033-61 pubmed publisher
    ..ability to create a working autonomous MAV depends mainly on integrating a simultaneous localization and mapping (SLAM) solution with the rest of the system...
  41. Jung J, Yoon S, Ju S, Heo J. Development of kinematic 3D laser scanning system for indoor mapping and as-built BIM using constrained SLAM. Sensors (Basel). 2015;15:26430-56 pubmed publisher
    ..kinematic 3D laser scanning system, proposed herein, uses line-feature-based Simultaneous Localization and Mapping (SLAM) technique for continuous mapping...
  42. Pratakpiriya W, Ping Teh A, Radtanakatikanon A, Pirarat N, Thi Lan N, Takeda M, et al. Expression of canine distemper virus receptor nectin-4 in the central nervous system of dogs. Sci Rep. 2017;7:349 pubmed publisher
    ..Initially, signaling lymphocyte activation molecule (SLAM) expressed on immune cells has been identified as a crucial cellular receptor for CDV...
  43. Morra M, Simarro Grande M, Martin M, Chen A, Lanyi A, Silander O, et al. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. J Biol Chem. 2001;276:36809-16 pubmed publisher
    ..interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors CD150/SLAM, CD84, CD229/Ly-9, and CD244/2B4...
  44. Wang Z, Medrzycki M, Bunting S, Bunting K. Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis. Oncotarget. 2015;6:28961-72 pubmed publisher
    ..Overall, these studies suggest that Stat5 can play multiple important roles that not only preserve the HSC compartment but can limit accumulation of potential pre-leukemic lymphoid populations. ..
  45. Haley S, Tzvetkov E, Meuwissen S, Plummer J, McGettigan J. Targeting Vaccine-Induced Extrafollicular Pathway of B Cell Differentiation Improves Rabies Postexposure Prophylaxis. J Virol. 2017;91: pubmed publisher
    ..To confirm that rRABV-mBAFF modulated the extrafollicular pathway, we used a signaling lymphocytic activation molecule (SLAM)-associated protein (SAP)-deficient mouse model...
  46. Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed publisher
    b>Signaling lymphocytic activation molecule family 1 (SLAMF1) is an Ig-like receptor and a costimulatory molecule that initiates signal transduction networks in a variety of immune cells...
  47. Mak A, Thornhill S, Lee H, Lee B, Poidinger M, Connolly J, et al. Brief report: Decreased expression of CD244 (SLAMF4) on monocytes and platelets in patients with systemic lupus erythematosus. Clin Rheumatol. 2018;37:811-816 pubmed publisher
    ..Thirty-nine SLE patients and twenty-nine healthy controls (HC) were evaluated for the expression of CD150, CD84, CD229, CD48, CD244, CD352 and CD319...
  48. Nam T, Shim J, Cho Y. A 2.5D Map-Based Mobile Robot Localization via Cooperation of Aerial and Ground Robots. Sensors (Basel). 2017;17: pubmed publisher
    ..for robots to perform tasks based on location information, they need a simultaneous localization and mapping (SLAM) process that uses sensor information to draw a map of the environment, while simultaneously estimating the current ..
  49. Menard L, Cantaert T, Chamberlain N, Tangye S, Riminton S, Church J, et al. Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. J Allergy Clin Immunol. 2014;133:1149-61 pubmed publisher
    b>Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) can mediate the function of SLAM molecules, which have been proposed to be involved in the development of autoimmunity in mice...
  50. Song T, Dong C, Xiong S. Signaling lymphocyte-activation molecule SLAMF1 augments mycobacteria BCG-induced inflammatory response and facilitates bacterial clearance. Int J Med Microbiol. 2015;305:572-80 pubmed publisher
    ..7 cells and mice. ..
  51. Howe H, Thong B, Kong K, Chng H, Lian T, Chia F, et al. Associations of B cell-activating factor (BAFF) and anti-BAFF autoantibodies with disease activity in multi-ethnic Asian systemic lupus erythematosus patients in Singapore. Clin Exp Immunol. 2017;189:298-303 pubmed publisher
    ..Correlation of serum BAFF and anti-BAFF IgG levels with disease activity [scored by SLE Activity Measure revised (SLAM-R)], and disease manifestations were determined in these 121 patients...
  52. Roch A, Trachsel V, Lutolf M. Brief Report: Single-Cell Analysis Reveals Cell Division-Independent Emergence of Megakaryocytes From Phenotypic Hematopoietic Stem Cells. Stem Cells. 2015;33:3152-7 pubmed publisher
    ..used an in vitro single-cell analysis approach to track the fate of 330 long-term HSCs (LT-HSC; Lin- cKit+ Sca-1+ CD150+ CD48- CD34-) cultured for 5 days under serum-free basal conditions...
  53. Santos P, Churata Salcedo J, Almeida L. New species and records of Menoscelis Mulsant (Coleoptera: Coccinellidae) from French Guiana. Zootaxa. 2016;4078:252-68 pubmed publisher
    ..flava sp. nov. (Holotype female deposited in MNHN: Montagne des Chevaux 04º44'56"N, 02º26'28"W, 14.I.2012, SLAM, SEAG col.). The male of M...
  54. Cho H, Yeon S, Choi H, Doh N. Detection and Compensation of Degeneracy Cases for IMU-Kinect Integrated Continuous SLAM with Plane Features. Sensors (Basel). 2018;18: pubmed publisher
    ..Results showed that the proposed framework could enhance map accuracy by successful detection and compensation of degenerated orientations. ..
  55. Iwasa T, Suga S, Qi L, Komada Y. Apoptosis of human peripheral blood mononuclear cells by wild-type measles virus infection is induced by interaction of hemagglutinin protein and cellular receptor, SLAM via caspase-dependent pathway. Microbiol Immunol. 2010;54:405-16 pubmed publisher
    ..Apoptosis of wild-type MV-infected PBMC was blocked by anti-SLAM and anti-MV hemagglutinin antibodies, respectively...
  56. Sherwin T, Easte M, Chen A, Wang K, Dai W. A Single RF Emitter-Based Indoor Navigation Method for Autonomous Service Robots. Sensors (Basel). 2018;18: pubmed publisher
    ..on the direction information, a motion control algorithm is proposed, using Simultaneous Localisation and Mapping (SLAM) and A* path planning to enable navigation through unknown complex environments...
  57. Maurus K, Appenzeller S, Roth S, Kuper J, Rost S, Meierjohann S, et al. Panel Sequencing Shows Recurrent Genetic FAS Alterations in Primary Cutaneous Marginal Zone Lymphoma. J Invest Dermatol. 2018;138:1573-1581 pubmed publisher
    ..From a diagnostic point of view, highly recurrent FAS mutations in PCMZL presumably separate this indolent lymphoma entity from pseudolymphoma, and this adds adjunctive discriminatory features at a molecular level. ..
  58. Turan M, Almalioglu Y, Araujo H, Konukoglu E, Sitti M. A non-rigid map fusion-based direct SLAM method for endoscopic capsule robots. Int J Intell Robot Appl. 2017;1:399-409 pubmed publisher
    ..The proposed method achieves high accuracy for extensive evaluations of pose estimation and map reconstruction performed on a non-rigid, realistic surgical EsophagoGastroDuodenoscopy Simulator and outperforms state-of-the art methods...
  59. Sim H, Kook S, Yun C, Bhattarai G, Cho E, Lee J. Brief Report: Consecutive Alendronate Administration-Mediated Inhibition of Osteoclasts Improves Long-Term Engraftment Potential and Stress Resistance of HSCs. Stem Cells. 2016;34:2601-2607 pubmed publisher
    ..caused by ALN treatment decreased mitochondrial reactive oxygen species (ROS) generation and SA-?-gal activity of CD150+ CD48- Lineage-Sca-1+ c-Kit+ (LSK) cells, eventually leading to an ..
  60. Kramer A, Blake A, Taisto M, Lehrke M, Webber B, Lund T. Dermatopontin in Bone Marrow Extracellular Matrix Regulates Adherence but Is Dispensable for Murine Hematopoietic Cell Maintenance. Stem Cell Reports. 2017;9:770-778 pubmed publisher
    ..CFU-C, LSK (Lineage-, SCA-1+, KIT+), and LSK-SLAM (LSK, CD48-, CD150+) frequencies...
  61. Karampetsou M, Comte D, Kis Toth K, Kyttaris V, Tsokos G. Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus. PLoS ONE. 2017;12:e0186073 pubmed publisher
    ..lupus erythematosus (SLE) identified the 1q23 region on human chromosome 1, containing the Signaling Lymphocytic Activation Molecule Family (SLAMF) cluster of genes, as a lupus susceptibility locus...
  62. Putlyaeva L, Schwartz A, Klepikova A, Vorontsov I, Kulakovskiy I, Kuprash D. The Minor Variant of the Single-Nucleotide Polymorphism rs3753381 Affects the Activity of a SLAMF1 Enhancer. Acta Naturae. 2017;9:94-102 pubmed
    The SLAMF1 gene encodes CD150, a transmembrane glycoprotein expressed on the surface of T and B-lymphocytes, NK-cells, dendritic cells, and subpopulations of macrophages and basophils...
  63. Sayos J, Martin M, Chen A, Simarro M, Howie D, Morra M, et al. Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP. Blood. 2001;97:3867-74 pubmed
    ..SAP binds to a specific motif in the cytoplasmic tails of the cell surface receptors SLAM and 2B4, where it blocks recruitment of the phosphatase SHP-2...
  64. Hwang P, Li C, Morra M, Lillywhite J, Muhandiram D, Gertler F, et al. A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J. 2002;21:314-23 pubmed
    ..by the X-linked lymphoproliferative (XLP) syndrome gene, associates with the hematopoietic cell surface receptor SLAM in a phosphorylation-independent manner...
  65. Finerty P, Muhandiram R, Forman Kay J. Side-chain dynamics of the SAP SH2 domain correlate with a binding hot spot and a region with conformational plasticity. J Mol Biol. 2002;322:605-20 pubmed
    ..SAP interacts with the Tyr281 site of the T<-->B cell signaling protein SLAM via its SH2 domain...
  66. Gu C, Tangye S, Sun X, Luo Y, Lin Z, Wu J. The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation. Proc Natl Acad Sci U S A. 2006;103:14447-52 pubmed
    b>SLAM (signaling lymphocyte activation molecule)-associated protein (SAP) is a Src homology 2 (SH2) domain-containing adaptor expressed in T cells and natural killer cells...
  67. Bieringer M, Han J, Kendl S, Khosravi M, Plattet P, Schneider Schaulies J. Experimental adaptation of wild-type canine distemper virus (CDV) to the human entry receptor CD150. PLoS ONE. 2013;8:e57488 pubmed publisher
    ..how fast such alterations may occur, we characterized required adaptive mutations to the human entry receptors CD150 (SLAM) and nectin-4 as first step to infect human target cells...
  68. Liñán Rico L, Hernández Castro B, Doníz Padilla L, Portillo Salazar H, Baranda L, Cruz Muñoz M, et al. Analysis of expression and function of the co-stimulatory receptor SLAMF1 in immune cells from patients with systemic lupus erythematosus (SLE). Lupus. 2015;24:1184-90 pubmed publisher
    The signaling lymphocytic activation molecule SLAMF1 (CD150) is a co-stimulatory molecule that is expressed by most immune cells, including T regulatory (Treg) lymphocytes...
  69. Alonso Rasgado T, Zhang Q, Jimenez Cruz D, Bailey C, Pinder E, Mandaleson A, et al. Analysis of tenodesis techniques for treatment of scapholunate instability using the finite element method. Int j numer method biomed eng. 2017;33: pubmed publisher
    ..This paper presents an investigation into the performance of the Corella, schapolunate axis (SLAM), and modified Brunelli tenodesis (MBT) surgical reconstruction techniques used to treat scapholunate instability...
  70. Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, et al. Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462-469. J Immunol. 2017;199:1534-1541 pubmed
  71. Radomir L, Cohen S, Kramer M, Bakos E, Lewinsky H, Barak A, et al. T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP. J Immunol. 2017;199:2745-2757 pubmed publisher
    ..We show that naive B and T cells interact via the signaling lymphocyte activation molecule (SLAM) family receptor, SLAMF6...
  72. Lewis J, Eiben L, Nelson D, Cohen J, Nichols K, Ochs H, et al. Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. Clin Immunol. 2001;100:15-23 pubmed
    ..associate with the cytoplasmic domains of several members of the CD2 subfamily of cell surface receptors, including SLAM, 2B4, and CD84...
  73. Masse N, Ainouze M, NEEL B, Wild T, Buckland R, Langedijk J. Measles virus (MV) hemagglutinin: evidence that attachment sites for MV receptors SLAM and CD46 overlap on the globular head. J Virol. 2004;78:9051-63 pubmed
    ..virus hemagglutinin (MVH) residues potentially responsible for attachment to the wild-type (wt) MV receptor SLAM (CD150) have been identified and localized on the MVH globular head by reference to a revised hypothetical structural ..
  74. Mehrle S, Frank S, Schmidt J, Schmidt Wolf I, Marten A. SAP and SLAM expression in anti-CD3 activated lymphocytes correlates with cytotoxic activity. Immunol Cell Biol. 2005;83:33-9 pubmed
    Signalling lymphocyte activation molecule (SLAM)-associated protein (SAP) is a small protein that is mutant in humans with X-linked lymphoproliferative (XLP) disease...
  75. Ovsyannikova I, Haralambieva I, Vierkant R, O Byrne M, Jacobson R, Poland G. The association of CD46, SLAM and CD209 cellular receptor gene SNPs with variations in measles vaccine-induced immune responses: a replication study and examination of novel polymorphisms. Hum Hered. 2011;72:206-23 pubmed publisher
    The measles virus (MV) interacts with two known cellular receptors: CD46 and SLAM. The transmembrane receptor CD209 interacts with MV and augments dendritic cell infection...
  76. Schweighofer C, Coombes K, Barron L, Diao L, Newman R, Ferrajoli A, et al. A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia. PLoS ONE. 2011;6:e28277 pubmed publisher
    ..the models with clinical variables: SKI (v-SKI avian sarcoma viral oncogene homolog) and SLAMF1 (signaling lymphocytic activation molecule family member 1; CD150)...
  77. Mitsuki Y, Terahara K, Shibusawa K, Yamamoto T, Tsuchiya T, Mizukoshi F, et al. HIV-1 infection ex vivo accelerates measles virus infection by upregulating signaling lymphocytic activation molecule (SLAM) in CD4+ T cells. J Virol. 2012;86:7227-34 pubmed publisher
    ..3- to 4-fold after HIV-1 infection, and this was associated with a marked upregulation of signaling lymphocytic activation molecule (SLAM) expression on CD4(+) T cells but not on CD8(+) T cells...
  78. Takeda S, Kanbayashi D, Kurata T, Yoshiyama H, Komano J. Enhanced susceptibility of B lymphoma cells to measles virus by Epstein-Barr virus type III latency that upregulates CD150/signaling lymphocytic activation molecule. Cancer Sci. 2014;105:211-8 pubmed publisher
    ..Cell surface levels of CD150/signaling lymphocytic activation molecule, a receptor of MV, were upregulated in B lymphoma cell lines with type III EBV latency by 3...
  79. Schwartz A, Putlyaeva L, Covich M, Klepikova A, Akulich K, Vorontsov I, et al. Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells. Biochim Biophys Acta. 2016;1859:1259-68 pubmed publisher
    b>Signaling lymphocytic activation molecule family member 1 (SLAMF1)/CD150 is a co-stimulatory receptor expressed on a variety of hematopoietic cells, in particular on mature lymphocytes activated by specific antigen, costimulation and ..
  80. Zhang Y, Liu X, Zhou J, Bottomley P. Ultrafast compartmentalized relaxation time mapping with linear algebraic modeling. Magn Reson Med. 2018;79:286-297 pubmed publisher
    ..accelerate compartmental-average longitudinal (T1 ) and transverse (T2 ) relaxation measurements using the minimal-acquisition linear algebraic modeling (SLAM) method, and to validate it in phantoms and humans.
  81. Li S, Gish G, Yang D, Coffey A, Forman Kay J, Ernberg I, et al. Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A. Curr Biol. 1999;9:1355-62 pubmed
    ..exclusively a single SH2 domain, which may modulate T-cell signaling by engaging T-cell co-activators such as SLAM, thereby blocking binding of other signaling proteins that contain SH2 domains...
  82. Dhiman N, Poland G, Cunningham J, Jacobson R, Ovsyannikova I, Vierkant R, et al. Variations in measles vaccine-specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors. J Allergy Clin Immunol. 2007;120:666-72 pubmed
    Measles infection requires 2 cellular receptors, signaling lymphocyte activation molecule (SLAM) and CD46...
  83. Mehrle S, Schmidt J, Buchler M, Watzl C, Marten A. Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP. Mol Immunol. 2008;45:796-804 pubmed
    Signaling lymphocyte activation molecule (SLAM, CD150) is a co-stimulatory receptor involved in T cell activation. The activity of CD150 is dependent on the intracellular signaling molecule SAP...
  84. Chandrasekaran P, Rajasekaran R. Structural characterization of disease-causing mutations on SAP and the functional impact on the SLAM peptide: a molecular dynamics approach. Mol Biosyst. 2014;10:1869-80 pubmed publisher
    ..characterized by severe immune dysregulation caused by mutations in signaling lymphocyte activation molecule (SLAM) associated protein (SAP) gene...
  85. Aldhamen Y, Rastall D, Chen W, Seregin S, Pereira Hicks C, Godbehere S, et al. CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets. Vaccine. 2016;34:3109-3118 pubmed publisher
    The CD2-like receptor activating cytotoxic cell (CRACC) receptor is a member of the SLAM family of receptors that are found on several types of immune cells...
  86. Claus M, Wingert S, Watzl C. Modulation of natural killer cell functions by interactions between 2B4 and CD48 in cis and in trans. Open Biol. 2016;6: pubmed publisher
    b>SLAM-related receptors (SRRs) are important modulators of immune cell function. While most SRRs are homophilic, 2B4 (CD244) interacts with CD48, a GPI-anchored protein expressed on many haematopoietic cells...
  87. Della Torre E, Stone J. "How I manage" IgG4-Related Disease. J Clin Immunol. 2016;36:754-763 pubmed
    ..A key driver of IgG4-RD is believed to be a novel CD4+ cytotoxic T lymphocyte that bears SLAM-F7 on its surface...
  88. Perez Mazliah D, Nguyen M, Hosking C, McLaughlin S, Lewis M, Tumwine I, et al. Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection. EBioMedicine. 2017;24:216-230 pubmed publisher
    ..to previous observations in immunization and viral infection models, Signaling Lymphocyte Activation Molecule (SLAM)-Associated Protein (SAP)-deficient mice were able to activate Tfh cells, GC B cells, and IgG responses to the ..
  89. Hahm B, Arbour N, Naniche D, Homann D, Manchester M, Oldstone M. Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule. J Virol. 2003;77:3505-15 pubmed
    ..Human signaling lymphocytic activation molecule (hSLAM) was identified as a receptor for wild-type MV as well as for MV strains prepared as ..
  90. Tabassum R, Mahajan A, Dwivedi O, Chauhan G, Spurgeon C, Kumar M, et al. Common variants of SLAMF1 and ITLN1 on 1q21 are associated with type 2 diabetes in Indian population. J Hum Genet. 2012;57:184-90 pubmed publisher
    ..19, P random effect=1.8 × 10(-4)). In conclusion, the study demonstrates that variants of SLAMF1 and ITLN1, both implicated in inflammation, are associated with type 2 diabetes in Indians. ..
  91. Gordiienko I, Shlapatska L, Kovalevska L, Sidorenko S. Differential expression of CD150/SLAMF1 in normal and malignant B cells on the different stages of maturation. Exp Oncol. 2016;38:101-7 pubmed
    Within B-cell lineage cell surface receptor CD150/SLAMF1 is broadly expressed starting from pre-B cells with upregulation toward plasma cells...
  92. Gonçalves Carneiro D, McKeating J, Bailey D. The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis. J Virol. 2017;91: pubmed publisher
    ..This research will impact our understanding of morbillivirus-related immunosuppression as well as the application of measles virus as an oncolytic therapeutic. ..