CD147

Summary

Gene Symbol: CD147
Description: basigin (Ok blood group)
Alias: 5F7, CD147, EMMPRIN, TCSF, basigin, OK blood group antigen, collagenase stimulatory factor, extracellular matrix metalloproteinase inducer, leukocyte activation antigen M6, tumor cell-derived collagenase stimulatory factor
Species: human

Top Publications

  1. ncbi Active site residues of cyclophilin A are crucial for its signaling activity via CD147
    Vyacheslav Yurchenko
    Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 277:22959-65. 2002
  2. ncbi Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN
    Yi Tang
    Oncology Research, Centocor, Inc, Malvern, PA 19087, USA
    Mol Cancer Res 2:73-80. 2004
  3. pmc Regulation of invadopodia formation and activity by CD147
    G Daniel Grass
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Cell Sci 125:777-88. 2012
  4. pmc CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma
    Larissa Sweeny
    Department of Surgery, University of Alabama, Division of Otolaryngology Head and Neck Surgery, Birmingham, Alabama, USA
    Exp Cell Res 318:1788-98. 2012
  5. pmc EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer
    Haining Zhu
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
    Prostate 72:72-81. 2012
  6. ncbi Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase in
    Joost P G Sluijter
    Experimental Cardiology Laboratory, University Medical Center, Utrecht, The Netherlands
    Stroke 37:235-9. 2006
  7. pmc The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells
    Jing Yao Dai
    Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, No 17 West Changle Road, Xi an 710032, Shaanxi, PR China
    BMC Cancer 9:337. 2009
  8. ncbi Upstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque
    Young Won Yoon
    Department of Internal Medicine and Cardiovascular Division, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
    Atherosclerosis 180:37-44. 2005
  9. doi Plasma CD147 reflects histological features in patients with lupus nephritis
    M Maeda-Hori
    1Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lupus 23:342-52. 2014
  10. ncbi The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen
    T Miyauchi
    Japan Immunoresearch Laboratories, Gunma
    J Biochem 110:770-4. 1991

Research Grants

  1. AGNIESZKA KENDRICK; Fiscal Year: 2015
  2. LOUISE DEBORAH MCCULLOUGH; Fiscal Year: 2014
  3. Cyclophilin-CD147 interaction in autoimmune arthritis
    Stephanie L Constant; Fiscal Year: 2010
  4. Yasuko Iwakiri; Fiscal Year: 2014
  5. Elan Z Eisenmesser; Fiscal Year: 2015
  6. NANCY JEAN PHILP; Fiscal Year: 2016
  7. RPE Lactate Transporters: A Role in Retinal Survival
    Nancy Philp; Fiscal Year: 2009
  8. Targeted Liposomal Delivery of CD147 siRNA to Murine Head and Neck Cancer Models
    Nadarajah Vigneswaran; Fiscal Year: 2010
  9. Pradeep K Dudeja; Fiscal Year: 2016
  10. Dissecting the molecular function of basigin a protein required for normal struct
    Kathryn D Curtin; Fiscal Year: 2010

Detail Information

Publications263 found, 100 shown here

  1. ncbi Active site residues of cyclophilin A are crucial for its signaling activity via CD147
    Vyacheslav Yurchenko
    Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 277:22959-65. 2002
    ..The mechanisms underlying CyPA-mediated signaling and chemotaxis are unknown. Here, we identified CD147 as a cell surface receptor for CyPA and demonstrated that CD147 is an essential component in the CyPA-initiated ..
  2. ncbi Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN
    Yi Tang
    Oncology Research, Centocor, Inc, Malvern, PA 19087, USA
    Mol Cancer Res 2:73-80. 2004
    ..pattern is, at least in part, regulated by tumor-stroma interaction via tumor cell-associated extracellular matrix metalloproteinase inducer (EMMPRIN)...
  3. pmc Regulation of invadopodia formation and activity by CD147
    G Daniel Grass
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    J Cell Sci 125:777-88. 2012
    ..CD147 (emmprin, basigin), an immunoglobulin superfamily protein that is associated with tumor invasion and metastasis, induces ..
  4. pmc CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma
    Larissa Sweeny
    Department of Surgery, University of Alabama, Division of Otolaryngology Head and Neck Surgery, Birmingham, Alabama, USA
    Exp Cell Res 318:1788-98. 2012
    ..b>CD147 is a transmembrane glycoprotein known to induce cell migration and invasion...
  5. pmc EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer
    Haining Zhu
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
    Prostate 72:72-81. 2012
    ..Proteins on cell surface play important roles during cancer progression and metastasis via their ability to mediate cell-to-cell interactions and navigate the communication between cells and the microenvironment...
  6. ncbi Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase in
    Joost P G Sluijter
    Experimental Cardiology Laboratory, University Medical Center, Utrecht, The Netherlands
    Stroke 37:235-9. 2006
    We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics.
  7. pmc The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells
    Jing Yao Dai
    Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, No 17 West Changle Road, Xi an 710032, Shaanxi, PR China
    BMC Cancer 9:337. 2009
    HAb18G/CD147 plays pivotal roles in invasion by hepatoma cells, but the underlying mechanism remains unclear. Our previous study demonstrated that overexpression of HAb18G/CD147 promotes invasion by interacting with integrin alpha3beta1...
  8. ncbi Upstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque
    Young Won Yoon
    Department of Internal Medicine and Cardiovascular Division, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
    Atherosclerosis 180:37-44. 2005
    ..Recently, extracellular MMPs inducer (EMMPRIN) has been reported to induce and activate the expression of MMPs in myocardium and plays an important role in the ..
  9. doi Plasma CD147 reflects histological features in patients with lupus nephritis
    M Maeda-Hori
    1Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Lupus 23:342-52. 2014
    A glycosylated transmembrane protein, CD147, has been implicated in regulating lymphocyte responsiveness and leukocyte recruitment...
  10. ncbi The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen
    T Miyauchi
    Japan Immunoresearch Laboratories, Gunma
    J Biochem 110:770-4. 1991
    b>Basigin belongs to the immunoglobulin superfamily and may be related to the primordial form of the superfamily...
  11. pmc Human tumor cells induce angiogenesis through positive feedback between CD147 and insulin-like growth factor-I
    Yanke Chen
    College of Medicine, Xi an Jiaotong University, Xi an, China
    PLoS ONE 7:e40965. 2012
    ..Previous studies have shown that CD147 was correlated with tumor angiogenesis through increasing tumor cell secretion of vascular endothelial growth ..
  12. pmc EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2
    Faten Bougatef
    INSERM, UMR S 940 Laboratoire de Pharmacologie, Paris, France
    PLoS ONE 5:e12265. 2010
    b>EMMPRIN's expression in melanoma tissue was reported to be predictive of poor prognosis...
  13. pmc Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration
    Marianne Pons
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
    Am J Pathol 178:2665-81. 2011
    ..RPE-derived matrix metalloproteinase (MMP)-2, MMP-14, and basigin (BSG) are major enzymes involved in the maintenance of ECM turnover...
  14. pmc Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphoma
    Z Qin
    Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Leukemia 25:1598-609. 2011
    ..The membrane-bound glycoprotein emmprin (CD147) enhances chemoresistance in tumors through effects on transporter expression, trafficking and ..
  15. pmc Basigin-2 is a cell surface receptor for soluble basigin ligand
    Robert J Belton
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Biol Chem 283:17805-14. 2008
    ..The immunoglobulin superfamily protein basigin (EMMPRIN/CD147) is a cell surface glycoprotein expressed by tumor cells that stimulates matrix metalloproteinase ..
  16. doi EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall
    C Schulz
    Deutsches Herzzentrum und I Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    J Thromb Haemost 9:1007-19. 2011
    ..Thereby, platelets interact intensively with monocytes and enhance their recruitment to the vascular wall...
  17. pmc Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-β1 and EMMPRIN
    Jasmina S Redzic
    Department of Biochemistry and Molecular Genetics, University of Colorado Denver, School of Medicine, Aurora, Colorado, USA
    PLoS ONE 8:e71225. 2013
    ..We confirmed that the transmembrane protein EMMPRIN, postulated to be a marker of EVs, was indeed secreted from all cell lines studied here...
  18. doi Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147
    Yangqiong Ou
    Laboratory of Immunopharmacology, Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, 100191 Beijing, People s Republic of China
    Rheumatol Int 31:1479-85. 2011
    b>CD147 expressed by monocytes, macrophages, and synoviocytes cells can stimulate the production of matrix metalloproteinases (MMPs) associated with the development of rheumatoid arthritis (RA)...
  19. doi Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model
    Nader Joghetaei
    Deutsches Herzzentrum und I Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Thorac Cardiovasc Surg 142:191-8. 2011
    ..Synthesis of certain matrix metalloproteinases is induced by the glycoprotein extracellular matrix metalloproteinase inducer. We investigated whether extracellular matrix metalloproteinase inducer and membrane-type 1 ..
  20. doi CD147 silencing via RNA interference reduces tumor cell invasion, metastasis and increases chemosensitivity in pancreatic cancer cells
    Yuqin Pan
    Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, PR China
    Oncol Rep 27:2003-9. 2012
    b>CD147, which belongs to the immunoglobulin superfamily, is a multifunctional glycoprotein that has been shown to increase tumor invasion, metastasis and multidrug resistance...
  21. doi Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages
    Yue Wang
    Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University Medical School, China
    Clin Exp Pharmacol Physiol 38:11-8. 2011
    1. Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) by monocytes/macrophages has been proposed to play a significant role in atherosclerotic plaque progression and rupture...
  22. ncbi EMMPRIN-mediated MMP regulation in tumor and endothelial cells
    Stephanie Caudroy
    INSERM U514, IFR53, CHU Maison Blanche, Reims, France
    Clin Exp Metastasis 19:697-702. 2002
    ..Among these factors, extracellular matrix metalloproteinase inducer (EMMPRIN) is known to increase in vitro stromal cell production of MMP-1, MMP-2 and MMP-3...
  23. ncbi LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147
    Panida Khunkaewla
    Department of Molecular Immunology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria
    Mol Immunol 45:1703-11. 2008
    ..physical association of CD43 with two novel partners, LFA-1 itself and the Ig-family member CD147 (EMMPRIN, basigin), and characterized how these interactions are involved in LFA-1-mediated cell adhesion...
  24. ncbi Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion
    T Muramatsu
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Histol Histopathol 18:981-7. 2003
    b>Basigin (Bsg) is a transmembrane glycoprotein with two immunoglobulin-like domains, and forms a family with embigin and neuroplastin. In these proteins a conserved glutamic acid is present in the middle for the transmembrane domain...
  25. pmc Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1
    Jun Zhou
    Department of Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, 17 Changlexilu, Xi an 710032, Shaanxi, P R China
    BMC Cell Biol 6:25. 2005
    ..We found in our study that CD147 played a very important role in this process.
  26. pmc Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis
    H C Zheng
    Department of Diagnostic Pathology, Graduate School of Medical and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Br J Cancer 95:1371-8. 2006
    ..Extracellular MMP inducer (EMMPRIN) was reported to involve in the progression of malignancies by regulating expression of VEGF and MMPs in stromal ..
  27. pmc Junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147
    Alexander Schreiner
    Institute of Cell Biology and Neuroscience, Johann Wolfgang Goethe University of Frankfurt, D 60323 Frankfurt am Main, Germany
    Mol Biol Cell 18:1272-81. 2007
    ..Logic suggested we looked for an interaction with CD147, a known promoter of invasiveness and MMP activity...
  28. doi Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts
    Takashi Sato
    Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Gynecol Oncol 114:337-42. 2009
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN) is highly expressed on malignant tumor cell surface and accelerates tumor invasion...
  29. ncbi The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily
    C Biswas
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111
    Cancer Res 55:434-9. 1995
    Tumor cell-derived collagenase stimulatory factor, renamed extracellular matrix metalloproteinase inducer (EMMPRIN), is a M(r) approximately 58,000 glycoprotein which is located on the outer surface of human tumor cells and which ..
  30. ncbi Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering
    Wei Tang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:11112-8. 2004
    b>CD147, a regulator of matrix metalloproteinase (MMP) production, showed highly specific association with caveolin-1 on the surface of multiple cell types...
  31. ncbi Regulation of CD147 cell surface expression: involvement of the proline residue in the CD147 transmembrane domain
    Vyacheslav Yurchenko
    Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    J Biol Chem 280:17013-9. 2005
    CD147, also known as extracellular matrix metalloproteinase inducer, is a regulator of matrix metalloproteinase production and serves as a signaling receptor for extracellular cyclophilins...
  32. ncbi Increased EMMPRIN (CD 147) expression during oral carcinogenesis
    Nadarajah Vigneswaran
    Department of Diagnostic Sciences, The University of Texas Health Science Center at Houston, Dental Branch, 6516 M D Anderson Blvd, Room 3 094G, Houston, TX 77030, USA
    Exp Mol Pathol 80:147-59. 2006
    Gene expression profiling of oral premalignant (OPM) cells and normal oral epithelial (NOR) cells showed that EMMPRIN expression was markedly upregulated in OPM cells compared to NOR cells...
  33. ncbi Inhibition of CD147 expression reduces tumor cell invasion in human prostate cancer cell line via RNA interference
    Liguo Wang
    Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi an City, China
    Cancer Biol Ther 5:608-14. 2006
    CD147, also named extracelluar matrix metalloproteinase inducer (EMMPRIN), has been proved to be involved in the invasion and metastasis processes of tumor cells in many types of cancers...
  34. ncbi The glycosylation characteristic of hepatoma-associated antigen HAb18G/CD147 in human hepatoma cells
    Xiao Ling Yu
    Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, PR China
    Int J Biochem Cell Biol 38:1939-45. 2006
    HAb18G/CD147 is a highly glycosylated transmembrane protein belonging to the immunoglobulin superfamily. Our previous studies have demonstrated that overexpressing HAb18G/CD147 enhances the metastatic potentials of human hepatoma cells...
  35. ncbi Involvement of CD147 in regulation of multidrug resistance to P-gp substrate drugs and in vitro invasion in breast cancer cells
    Qing Quan Li
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Cancer Sci 98:1064-9. 2007
    ..We aimed to clarify the mechanism(s) underlying this observation and transfected vectors carrying CD147, a glycoprotein enriched on the surface of tumor cells that stimulates the production of matrix metalloproteinases ..
  36. pmc Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells
    Danilo Millimaggi
    Department of Experimental Medicine, L Aquila University, L Aquila, Italy
    Neoplasia 9:349-57. 2007
    ..Several studies have demonstrated that CD147/extracellular MMP inducer, a membrane-spanning molecule highly expressed in tumor cells, may be involved in the ..
  37. ncbi HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma
    Jing Xu
    Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, 17 West Changle Street, Xi an 710032, China
    Mol Cancer Res 5:605-14. 2007
    b>CD147 molecule is reported to be correlated with the malignancy of some cancers; however, it remains unclear whether it is involved in the progression of hepatocellular carcinoma (HCC)...
  38. doi EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer
    Xing Zhu Ju
    Department of Gynecologic Oncology, The Cancer Hospital of Fudan University, Shanghai, China
    Clin Cancer Res 14:494-501. 2008
    Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN), a member of the immunoglobulin family and a glycoprotein enriched on the surface of many types of tumor cells, has been reported to be linked to invasion, ..
  39. doi Extracellular matrix metalloproteinase inducer is expressed in the proximal tubular epithelial cells of the human kidney
    Michiko Shimada
    Department of Nephrology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Nephrology (Carlton) 14:171-8. 2009
    Matrix metalloproteinases (MMP) affect matrix remodelling, and extracellular matrix metalloproteinase inducer (EMMPRIN) has been reported to increase the levels of several MMP...
  40. ncbi EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction
    Peter Seizer
    Medizinische Klinik III, Universitatsklinikum Tubingen, Tubingen, Germany
    Thromb Haemost 101:682-6. 2009
    The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147, basigin) is an immunoglobulin-like receptor expressed in various cell types...
  41. doi CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value
    Yu Xiang Liang
    Guangzhou First Municipal People s Hospital, Affiliated Guangzhou Medical College, Guangzhou, China
    Cancer Invest 27:788-93. 2009
    To investigate the clinicopathologic characteristics of extracellular matrix (ECM) metalloproteinase inducer (CD147) and vascular endothelial growth factor (VEGF) expression in advanced renal cell carcinoma (RCC), and to evaluate the ..
  42. doi CD147/basigin promotes progression of malignant melanoma and other cancers
    Takuro Kanekura
    Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    J Dermatol Sci 57:149-54. 2010
    CD147/basigin, a transmembrane protein belonging to the immunoglobulin super family, was originally cloned as a carrier of Lewis X carbohydrate antigen...
  43. doi EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis
    S S Sidhu
    Divisions of Pulmonary and Critical Care and Allergy Immunology, Department of Medicine, University of California at San Francisco, San Francisco, CA, USA
    Oncogene 29:4145-56. 2010
    ..One such pathway is the Wnt/beta-catenin signaling pathway. High levels of EMMPRIN expression have been shown to correlate with poor prognosis and metastasis in a broad range of tumors...
  44. doi Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells
    Chan Zhu
    Department of Life Sciences, Nanjing Normal University, and Central Laboratory, Nanjing First Hospital, Nanjing, Jiangsu 210046, PR China
    Oncol Rep 25:425-32. 2011
    CD147, also named extracelluar matrix metalloproteinase inducer (EMMPRIN), is a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, which promotes invasion, metastasis, growth and survival of ..
  45. doi Expression of CD147 is associated with prostate cancer progression
    Wei de Zhong
    Department of Urology, Guangzhou First Municipal People s Hospital, Guangzhou Medical College, Guangzhou, China
    Int J Cancer 130:300-8. 2012
    ..b>Extracellular matrix metalloproteinase inducer (CD147) has been demonstrated to be involved in tumor invasion, metastasis, growth and ..
  46. doi HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-β signaling and is transcriptionally regulated by Slug
    J Wu
    Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an, China
    Oncogene 30:4410-27. 2011
    ..HAb18G/CD147, which belongs to the CD147 family, is an HCC-associated antigen that has a crucial role in tumor invasion and ..
  47. doi Decreased RECK and Increased EMMPRIN expression in urothelial carcinoma of the bladder are associated with tumor aggressiveness
    Daniel Wittschieber
    Institute of Pathology, Charite University Hospital, Berlin, Germany d wittschieber gmx de
    Pathobiology 78:123-31. 2011
    ..The MMP repressor RECK and the MMP activator EMMPRIN regulate the invasive potential by metalloproteinase-induced stromal degradation...
  48. pmc Role of emmprin in endometrial cancer
    Keiichiro Nakamura
    Department of Obstetrics and Gynecology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    BMC Cancer 12:191. 2012
    b>Extracellular matrix metalloproteinase inducer (Emmprin/CD147) is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily...
  49. ncbi Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases
    H Guo
    Department of Anatomy and Cellular Biology, Tufts Medical School, Boston, Massachusetts, USA
    Gene 220:99-108. 1998
    EMMPRIN (extracellular matrix metalloproteinase inducer) also known as CD147 and basigin, is a member of the immunoglobulin family that is present on the surface of tumor cells and stimulates nearby fibroblasts to synthesize matrix ..
  50. ncbi Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain
    S Yoshida
    Departments of Biochemistry, Obstetrics and Gynecology, and Pathology, Nagoya University School of Medicine, Japan
    Eur J Biochem 267:4372-80. 2000
    b>Basigin (Bsg) is a highly glycosylated transmembrane protein with two immunoglobulin (Ig)-like domains...
  51. pmc CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
    P Kirk
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    EMBO J 19:3896-904. 2000
    b>CD147 is a broadly expressed plasma membrane glycoprotein containing two immunoglobulin-like domains and a single charge-containing transmembrane domain...
  52. ncbi Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells
    Jin Ming Yang
    Department of Pharmacology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Mol Cancer Res 1:420-7. 2003
    ..to clarify the mechanism(s) underlying these observations, we studied the expression of extracellular matrix metalloproteinase inducer (EMMPRIN), a glycoprotein enriched on the surface of tumor cells that can stimulate the ..
  53. ncbi The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions
    Sukhvinder S Sidhu
    Biomolecular Sciences Program, Cardiovascular Research Institute and Department of Anatomy, UCSF, San Francisco, CA 94143, USA
    Oncogene 23:956-63. 2004
    b>EMMPRIN is a transmembrane glycoprotein expressed at high levels by tumor cells...
  54. pmc Links between CD147 function, glycosylation, and caveolin-1
    Wei Tang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 15:4043-50. 2004
    Cell surface CD147 shows remarkable variations in size (31-65 kDa) because of heterogeneous N-glycosylation, with the most highly glycosylated forms functioning to induce matrix metalloproteinase (MMP) production...
  55. ncbi Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases
    Yi Tang
    Oncology Research, Centocor, Inc, Malvern, Pennsylvania, USA
    Cancer Res 65:3193-9. 2005
    ..cells and is partially regulated by tumor-stroma interactions via tumor cell-associated extracellular matrix metalloproteinase inducer (EMMPRIN)...
  56. ncbi Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)
    Marieangela C Wilson
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 280:27213-21. 2005
    Translocation of monocarboxylate transporters MCT1 and MCT4 to the plasma membrane requires CD147 (basigin) with which they remain tightly associated. However, the importance of CD147 for MCT activity is unclear...
  57. pmc Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production
    Ping Zhu
    Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Arthritis Res Ther 7:R1023-33. 2005
    ..molecules, including IL-1 and tumor necrosis factor-alpha, but there have been very few reports on the role of CD147 in RA...
  58. ncbi EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma
    Cornelis F M Sier
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Int J Cancer 118:2991-8. 2006
    ..of MMP-2 in cervical squamous cell carcinomas in comparison with MT1-MMP (MMP-14), TIMP-2 and extracellular matrix metalloproteinase inducer (EMMPRIN)...
  59. ncbi Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters
    Jong Shiaw Jin
    Department of Pathology, and Division of Urology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Int J Gynecol Pathol 25:140-6. 2006
    ..that are thought to be induced by tumor cell-derived extracellular matrix metalloprotease inducer (EMMPRIN) in surrounding fibroblasts. We hypothesized that EMMPRIN isoverexpressed in ovary tumors...
  60. ncbi Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3K-Akt signaling pathway
    Yi Tang
    Oncology Research, Centocor R and D, Inc, Malvern, Pennsylvania 19355, USA
    Mol Cancer Res 4:371-7. 2006
    Extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN) is a cell surface glycoprotein overexpressed in many solid tumors...
  61. pmc The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity
    Christine Manoharan
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol, UK
    Mol Membr Biol 23:486-98. 2006
    Monocarboxylate transporters MCT1-MCT4 require basigin (CD147) or embigin (gp70), ancillary proteins with a glutamate residue in their single transmembrane (TM) domain, for plasma membrane (PM) expression and activity...
  62. ncbi Epitope mapping of series of monoclonal antibodies against the hepatocellular carcinoma-associated antigen HAb18G/CD147
    X M Ku
    Cell Engineering Research Center and Department of Cell Biology, State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Scand J Immunol 65:435-43. 2007
    The hepatocellular carcinoma-associated antigen HAb18G/CD147, a member of CD147 family, could promote tumour invasion and metastasis via inducing the secretion of matrix metalloproteinases (MMP)...
  63. ncbi Up-regulation of CD147 and matrix metalloproteinase-2, -9 induced by P-glycoprotein substrates in multidrug resistant breast cancer cells
    Qing Quan Li
    Department of Pathology, Shanghai Medical College, Fudan University, No 138, Yixueyuan Road, Shanghai 200032, China
    Cancer Sci 98:1767-74. 2007
    ..Increased production of CD147, and matrix metalloproteinases (MMP)-2, -9 was observed only in MDR cancer cells exposed to P-gp substrates, as ..
  64. ncbi Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer
    S Sillanpää
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Kuopio, Finland
    Tumour Biol 28:280-9. 2007
    We investigated the prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase 2 (MMP-2) in epithelial ovarian cancer as well as their relation to hyaluronan (HA) expression.
  65. doi The role of extracellular matrix metalloproteinase inducer protein in prostate cancer progression
    Michele C Madigan
    Discipline of Clinical Ophthalmology, Save Sight Institute, University of Sydney, GPO Box 4337, Sydney, NSW 2001, Australia
    Cancer Immunol Immunother 57:1367-79. 2008
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) is a multifunctional membrane glycoprotein overexpressed in many solid tumors, and involved in tumor invasion and angiogenesis...
  66. doi A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis
    Juan Su
    Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Cancer Lett 273:140-7. 2009
    ..Our previous results revealed that the over-expressed CD147/basigin plays a critical role in malignant melanoma (MM) invasiveness, metastasis and angiogenesis; CD147 has also been ..
  67. doi CD147, MMP-1, MMP-2 and MMP-9 protein expression as significant prognostic factors in human prostate cancer
    Wei de Zhong
    Guangzhou First Municipal People s Hospital, Affiliated Guangzhou Medical College, Guangzhou, China
    Oncology 75:230-6. 2008
    b>CD147 and MMPs have been demonstrated to be involved in tumor invasion and angiogenesis...
  68. pmc Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells
    Mark G Slomiany
    Departments of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Cancer Res 69:1293-301. 2009
    ..b>Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in ..
  69. pmc Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44
    Celine Pinheiro
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus of Gualtar, 4710 057 Braga, Portugal
    J Biomed Biotechnol 2010:427694. 2010
    ..study, we analysed MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as CD147 and CD44. MCT expression frequency was high and heterogeneous among the different tumours...
  70. doi Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    J Cancer Res Clin Oncol 137:585-96. 2011
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN) was reported to involve in the invasion and metastasis of malignancies by regulating the expression of vascular endothelial growth factor (VEGF) in stromal and cancer cells...
  71. pmc RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro
    Bo Wang
    Department of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China
    J Exp Clin Cancer Res 29:61. 2010
    b>CD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily. CD147 has been implicated in numerous physiological and pathological activities...
  72. doi Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression
    Hongmin Chen
    Department of Gynecologic Oncology, Henan Cancer Hospital, Zhengzhou, China
    Clin Exp Metastasis 27:557-69. 2010
    ..We evaluated CD147, monocarboxylate transporters (MCT1 and MCT4), and multidrug resistance (MDR) markers (MDR1 and MRP2) in 4 ..
  73. doi Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density
    Zhi Quan Huang
    Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China
    J Craniofac Surg 21:1855-60. 2010
    The purpose of this study was to investigate the expression pattern of extracellular matrix metalloproteinase inducer (EMMPRIN) as well as the correlation between EMMPRIN and microvessel density (MVD) in salivary gland tumors...
  74. ncbi Expression of CD147 in advanced non-small cell lung cancer correlated with cisplatin-based chemotherapy resistance
    H Z Zeng
    School of Life Sciences and Technology, Tongji Univesity, Shanghai 200092, China
    Neoplasma 58:449-54. 2011
    b>CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy...
  75. doi Clinical impact of HAb18G/CD147 expression in esophageal squamous cell carcinoma
    Shaojun Zhu
    The Helmholtz Sino German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi an 710038, Shaanxi, People s Republic of China
    Dig Dis Sci 56:3569-76. 2011
    HAb18G/CD147 expression has been associated with many tumor invasion molecules, which play important roles in recurrence and poor differentiation of esophageal squamous cell carcinoma (ESCC)...
  76. pmc Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin β1 to modulate malignant properties of hepatoma cells
    Yong Li
    Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an 710032, China
    J Biol Chem 287:4759-72. 2012
    Several lines of evidence suggest that HAb18G/CD147 interacts with the integrin variants α3β1 and α6β1. However, the mechanism of the interaction remains largely unknown...
  77. doi Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma
    Songlin Piao
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, People s Republic of China
    J Cancer Res Clin Oncol 138:627-35. 2012
    The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC.
  78. doi Increased serum soluble CD147 levels in patients with systemic sclerosis: association with scleroderma renal crisis
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Rheumatol 31:835-9. 2012
    b>CD147 is a glycosylated membrane protein that belongs to the immunoglobulin superfamily. This study aimed to determine serum soluble CD147 (sCD147) levels and their clinical associations in patients with systemic sclerosis (SSc)...
  79. doi Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway
    Hong Yong Cui
    State Key Laboratory of Cancer Biology, Cell Engineering Research Center and Department of Cell Biology, Fourth Military Medical University, Xi an, China
    Biochem Biophys Res Commun 419:517-22. 2012
    HAb18G/CD147 is a transmembrane glycoprotein of the immunoglobulin superfamily (IgSF) and is reported to be correlated with invasion and metastasis of many cancers...
  80. doi High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer
    Albrecht Stenzinger
    Institute of Pathology, University of Heidelberg, and National Center for Tumor Diseases, 69120 Heidelberg, Germany
    Hum Pathol 43:1471-81. 2012
    ..b>Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that activates matrix metalloproteinases, a group of ..
  81. pmc CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells
    Lu Dai
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Pathol 182:577-85. 2013
    CD147 (alias emmprin or basigin), an integral plasma membrane glycoprotein and a member of the Ig superfamily, is widespread in normal tissues, but highly up-regulated in many types of malignant cancer cells...
  82. doi Overexpression of CD147 contributes to the chemoresistance of head and neck squamous cell carcinoma cells
    Zhiquan Huang
    Department of Oral and Maxillofacial Surgery, Sun Yat Sen Memorial Hospital, Sun Yat Sen University, Guangzhou, China
    J Oral Pathol Med 42:541-6. 2013
    ..However, the mechanisms underlying cisplatin resistance is still largely unrevealed. In this study, we found that CD147 was overexpressed in cisplatin-resistant HNSCC cell lines...
  83. doi Prognostic significance of CD147 in patients with glioblastoma
    Min Yang
    Institute of Orthopaedics and Traumatology of PLA of China, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, Shaanxi, People s Republic of China
    J Neurooncol 115:19-26. 2013
    CD147, also known as extracellular matrix metalloproteinase inducer, is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin superfamily...
  84. doi CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance
    G Daniel Grass
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA Electronic address
    Adv Cancer Res 123:351-73. 2014
    ..CD147 (emmprin; basigin) is a member of the Ig superfamily that has also been strongly implicated in chemoresistance and ..
  85. ncbi Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60
    Tatiana Pushkarsky
    The George Washington University Medical Center, Washington, DC 20037, USA
    J Biol Chem 280:27866-71. 2005
    CD147, also known as extracellular matrix metalloproteinase inducer, is a regulator of matrix metalloproteinase production and also serves as a signaling receptor for extracellular cyclophilins...
  86. ncbi Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule
    W Kasinrerk
    Institute of Immunology Vienna International Research Cooperation Center, Sandoz Forschungsinstitut, Austria
    J Immunol 149:847-54. 1992
    ..sequence indicates that M6 Ag is a member of the Ig superfamily and the species homologue of rat OX-47 Ag, mouse basigin (gp42), and chicken HT7 molecule...
  87. ncbi Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer
    R DeCastro
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Invest Dermatol 106:1260-5. 1996
    ..We have previously isolated and purified a tumor cell surface protein, EMMPRIN (extracellular matrix metalloproteinase inducer), which stimulates production of interstitial collagenase, gelatinase A, and stromelysin-1 by ..
  88. ncbi The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues
    F A Spring
    Bristol Institute for Transfusion Sciences, GB
    Eur J Immunol 27:891-7. 1997
    ..There are homologs in rat (MRC OX-47 or CE9), in mouse (basigin or gp42), and in chicken (HT7 or neurothelin)...
  89. ncbi Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts
    Takuro Kanekura
    Department of Dermatology, Kagoshima University Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8530, Japan
    Int J Cancer 99:520-8. 2002
    EMMPRIN, which is identical to human basigin (CD147), interacts with fibroblasts and stimulates expression of MMPs, which play an important role in tumor invasiveness and metastasis...
  90. ncbi Extracellular matrix metalloproteinase inducer (EMMPRIN) is induced upon monocyte differentiation and is expressed in human atheroma
    Terry C Major
    Cardiovascular Pharmacology, Pfizer Global Research and Development, Pfizer, Inc, Ann Arbor, Mich 48105, USA
    Arterioscler Thromb Vasc Biol 22:1200-7. 2002
    Because extracellular matrix metalloproteinase inducer (EMMPRIN), a tumor cell-derived protein, induces matrix metalloproteinases (MMPs) in fibroblasts and because MMPs are important in atheroma formation, we investigated if EMMPRIN was ..
  91. ncbi Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway
    Paul M Taylor
    Cancer Research UK Institute for Cancer Studies, Birmingham University, Birmingham, B15 2TT, UK
    Oncogene 21:5765-72. 2002
    ..In this report we demonstrate that breast cancer cells in culture release apparently full length soluble EMMPRIN that promotes the release of pro-MMP2 from fibroblasts...
  92. ncbi Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily
    Judith D Ochrietor
    Whitney Laboratory of the University of Florida, St Augustine, Florida 32080, USA
    Invest Ophthalmol Vis Sci 44:4086-96. 2003
    5A11/Basigin has recently been identified as a critical glycoprotein for full maturity and function of the mouse retina. However, the biological function of 5A11/Basigin has yet to be determined...
  93. ncbi Identification and characterization of extracellular matrix metalloproteinase inducer in human endometrium during the menstrual cycle in vivo and in vitro
    Yutaka Noguchi
    Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    J Clin Endocrinol Metab 88:6063-72. 2003
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN) participates in the breakdown of the extracellular matrix (ECM) by augmenting matrix metalloproteinase (MMP) expression...
  94. ncbi Direct cell-cell interaction enhances pro-MMP-2 production and activation in co-culture of laryngeal cancer cells and fibroblasts: involvement of EMMPRIN and MT1-MMP
    Shinsuke Suzuki
    Department of Otolaryngology, Akita University School of Medicine, Akita 010 8543, Japan
    Exp Cell Res 293:259-66. 2004
    ..Recently, EMMPRIN/CD147, which is a member of immunoglobulin superfamily, has been reported to be highly expressed in tumor cells ..
  95. ncbi Expression of extracellular matrix metalloproteases inducer on micrometastatic and primary mammary carcinoma cells
    Natalie Reimers
    Institute of Tumor Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 10:3422-8. 2004
    b>EMMPRIN (extracellular matrix metalloprotease inducer) is a glycosylated member of the immunoglobulin superfamily known to stimulate the production of matrix metalloproteases (MMPs) 1, 2, and 3 and MT1-MMP in peritumoral fibroblasts...
  96. pmc Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction
    Eric E Gabison
    Institut de Recherche sur la Peau, Hopital St Louis, INSERM U 532, 1 avenue Claude Vellefaux, 75010 Paris, France
    Am J Pathol 166:209-19. 2005
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN) was originally identified on the tumor cell surface as an inducer of matrix metalloproteinase (MMP) production in neighboring fibroblasts...
  97. ncbi Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression
    Li Yan
    Oncology, Centocor Inc, Radnor, Pennsylvania, USA
    Thromb Haemost 93:199-204. 2005
    Emmprin (basigin;CD147) is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of malignant tumour cells...
  98. pmc Clinicopathological significance of expression of paxillin, syndecan-1 and EMMPRIN in hepatocellular carcinoma
    Hai Gang Li
    Department of Oncology, Second Affiliated Hospital to Sun Yat Sen University, Guangzhou 510120, Guangdong Province, China
    World J Gastroenterol 11:1445-51. 2005
    To evaluate the relationship of expression of paxillin, syndecan-1 and EMMPRIN proteins with clinicopathological features in hepatocellular carcinoma (HCC).
  99. ncbi Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim
    Jin Ming Yang
    Department of Pharmacology, Medicine and Surgery, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Biol Chem 281:9719-27. 2006
    Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, promotes invasion, metastasis, and growth and survival ..
  100. ncbi Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction
    Roland Schmidt
    Deutsches Herzzentrum und Medizinische Klinik I, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Circulation 113:834-41. 2006
    ..It has been suggested that, on tumor cells, the extracellular MMP inducer (EMMPRIN) is involved in MMP synthesis by as yet unknown mechanisms...
  101. pmc CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes
    Ping Zhu
    Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, Shaanxi Province, PR China
    Arthritis Res Ther 8:R44. 2006
    ..The present article studied the expression of CD147, also called extracellular matrix metalloproteinase inducer, on monocytes/macrophages and FLS from RA patients and its potential role in enhancing MMPs ..

Research Grants55

  1. AGNIESZKA KENDRICK; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, also called CD147) is highly expressed in multiple cancers, particularly in pancreatic cancer where it stimulates secretion of entire ..
  2. LOUISE DEBORAH MCCULLOUGH; Fiscal Year: 2014
    ..b>Extracellular Matrix Metalloproteinase Inducer (EMMPRIN;CD 147) is a 58-kDa cell surface glycoprotein that regulates leukocyte trafficking ..
  3. Cyclophilin-CD147 interaction in autoimmune arthritis
    Stephanie L Constant; Fiscal Year: 2010
    PROJECT SUMMARY/ABSTRACT Cyclophilins and CD147 in autoimmune arthritis Inflammatory destruction of target organs in autoimmune diseases, including rheumatoid arthritis (RA), begins with the emigration of effector cells from the ..
  4. Yasuko Iwakiri; Fiscal Year: 2014
    ..EMMPRIN, extracellular matrix metalloproteinase inducer, plays an important role in vascular remodeling and tumor invasion, by inducing activation of ..
  5. Elan Z Eisenmesser; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) is highly expressed in multiple cancers and inflammatory disorders where it stimulates secretion of matrix metalloproteinases (MMPs) and ..
  6. NANCY JEAN PHILP; Fiscal Year: 2016
    ..Both transporters are linked to CD147, an accessory protein required for proper trafficking to the plasma membrane...
  7. RPE Lactate Transporters: A Role in Retinal Survival
    Nancy Philp; Fiscal Year: 2009
    ..Both transporters are linked to CD147, an accessory protein required for proper trafficking to the plasma membrane...
  8. Targeted Liposomal Delivery of CD147 siRNA to Murine Head and Neck Cancer Models
    Nadarajah Vigneswaran; Fiscal Year: 2010
    ..CD147 (Emmprin), which is overexpressed in HNSCC, mediates tumor-microenvironment cross-talk and plays a critical role in tumor ..
  9. Pradeep K Dudeja; Fiscal Year: 2016
    ..cells showed that acute treatment with butyrate (10 mM, 60-120 min) increased MCT1 function and association with CD147 (the ancillary chaperon protein), enhanced apical surface MCT1 level, and decreased intracellular cAMP levels...
  10. Dissecting the molecular function of basigin a protein required for normal struct
    Kathryn D Curtin; Fiscal Year: 2010
    ..One gene that may play a role in retinopathy is the basigin gene (aka EMMPRIN in humans)...
  11. Eben L Rosenthal; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Extracellular matrix metalloprotease inducer (EMMPRIN or CD147) is a tumor cell surface molecule that is known to promote tumor growth in epithelial malignancies and is highly expressed in head and ..
  12. Tumor Stromal Interactions in Head and Neck Cancer
    Eben Rosenthal; Fiscal Year: 2009
    ..This application proposes to investigate the role of extracellular matrix metalloproteinase inducer (EMMPRIN) in head and neck squamous cell carcinoma (HNSCC) as a paradigm for understanding the ..
  13. Cell Biology of Presenilin 1 and Associated Proteins
    Gopal Thinakaran; Fiscal Year: 2012
    ..of four main subunits, namely PS1 (or PS2), nicastrin, PEN2 and APH-1, and a few regulatory subunits including CD147 and p23 (also referred to asTMP21). PS1 is thought to function as the catalytic subunit of gamma-secretase complex...
  14. Targeting a Poor Prognosis Marker for Tumor Therapy
    Douglas A Lappi; Fiscal Year: 2010
    ..This proposal describes an experimental design to verify the suitability of basigin-2 (also known as CD147 or EMMPRIN) as a cell surface target for an innovative tumor therapy...
  15. CD147 Biological Function and Role as a Biomarker of MGUS to Myeloma Progression
    Diane F Jelinek; Fiscal Year: 2013
    ..preliminary studies, we have obtained provocative evidence that the transmembrane CD147 molecule, also known as EMMPRIN (extracellular matrix metalloproteinase [MMP] inducer), may be playing an important biological role in MM PCs and ..
  16. Viral receptors of the visual nervous system
    Mark Greene; Fiscal Year: 2007
    ..has been biochemically isolated and found to be composed of two subunits: a 35-65 kD glycosylated protein (CD147) and a 95 kD protein...
  17. The Role of Gelatinase B in Terminal Airway Remodeling
    Robert Senior; Fiscal Year: 2005
    ..Recent studies have shown that extracellular matrix metalloproteinase inducer, EMMPRIN, is prominent in alveolar and terminal airway epithelium in human pulmonary fibrosis ..
  18. MATRIX REMODELING IN ORAL SQUAMOUS CELL CARCINOMA
    Daniel Ramos; Fiscal Year: 2000
    ..others showed that a transmembrane molecule found on the surface of some tumor cells, extracellular matrix metalloproteinase inducer (EMMPRIN), stimulates matrix metalloproteinase (MMP) secretion by peritumor fibroblasts...
  19. Commercializing digital wireless telemetry: the animal epilepsy monitoring unit
    Andre Fenton; Fiscal Year: 2009
    ....
  20. FIBROBLAST TUMOR CELL INTERACTIONS IN TUMOR INVASION
    CHITRA BISWAS; Fiscal Year: 1992
    ..have shown that fibroblasts are stimulated to produce type I collagen-degrading enzyme by a tumor cell factor (TCSF) present on the tumor cell membrane...
  21. Contribution of cyclophilins to leukocyte recruitment in lung inflammation
    Stephanie Constant; Fiscal Year: 2009
    ..including neutrophils, eosinophils, and T lymphocytes, by a mechanism that is dependent on the presence of CD147 receptors...
  22. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Donna Futterman; Fiscal Year: 2001
    ....
  23. Role of cyclophilins in leukocyte recruitment in asthma
    Stephanie Constant; Fiscal Year: 2005
    ..Our group has recently identified CD147 as the receptor for cyclophilins A and B and we have shown that CD147 is required for cyclophilin-induced ..
  24. Regulation of leukocyte trafficking by cyclophilins
    Stephanie Constant; Fiscal Year: 2005
    ..Our group has previously identified CD147 as the receptor for cyclophilins A and B...
  25. Role of EMMPRIN in Retinal Physiology
    Ami Deora; Fiscal Year: 2004
    ..Extracellular matrix metalloproteinases inducer, EMMPRIN is one of the proteins that exhibits reversed polarity in adult RPE...
  26. REGULATION OF MULTIDRUG RESISTANCE PHENOTYPE
    Jin Ming Yang; Fiscal Year: 2007
    ..quantities of metalloproteinases than parental cell lines and that these activities appeared to be regulated by EMMPRIN (extra cellular matrix metalloproteinase inducers), a cell surface glycoprotein that regulates the activities of ..
  27. Role of Fibroblast-Derived MT1-MMP in Oral Cancer
    Eben Rosenthal; Fiscal Year: 2006
    ..abstract_text> ..
  28. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
  29. MIBG ANALOGUE RADIOPHARMACEUTICALS
    Ganesan Vaidyanathan; Fiscal Year: 2001
    ..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
  30. Interactions of CD147 Involved in MMP Induction
    MARTIN HEMLER; Fiscal Year: 2008
    The cell surface IgSF protein CD147/EMMPRIN/basigin, binds to peritumor stromal cells or to other tumor cells, leading to MMP production, extracellular matrix degradation, and elevated tumor invasion and metastasis...
  31. HIV Impairs Reverse Cholesterol Transport
    Michael Bukrinsky; Fiscal Year: 2006
    ..These studies are expected to yield sufficient information upon which to base a well-planned and rigorous series of further investigations. [unreadable] [unreadable]..
  32. Imaging Technology for HIV Nuclear Import Inhibitors
    Michael Bukrinsky; Fiscal Year: 2003
    ..The imaging technology will greatly augment the value of the project by adding a superior method for analyzing the activity of the drugs. ..
  33. NUCLEAR TRANSLOCATION OF HIV 1 GENOME AS A DRUG TARGET
    Michael Bukrinsky; Fiscal Year: 2004
    ..Upon completion, these studies are expected to define potent anti-HIV compounds working through a novel mechanism different from that of any other currently used drug. ..
  34. Oxadaizols: Rationally designed compounds targeting HIV nuclear importation
    Michael Bukrinsky; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. The Role of Vpr in HIV-1 Nuclear Translocation
    Michael Bukrinsky; Fiscal Year: 2006
    ..These results will be significant, because they are expected to facilitate discovery of agents that would inhibit Vpr activity and thus attenuate HIV replication. ..
  36. CD4+ memory T cell recruitment by cyclophilin
    Michael Bukrinsky; Fiscal Year: 2004
    ..Our studies identified CD147 as a cellular receptor for both CypA and CypB...
  37. Leukocyte recruitment by cyclophilinc-CD147 interaction
    Michael Bukrinsky; Fiscal Year: 2005
    ..Our studies identified CD147 as a cell surface receptor for extracellular cyclophilins...
  38. TUMOR CELL STROMAL INTERACTIONS IN CANCER
    Bryan Toole; Fiscal Year: 2004
    ..The tumor cell surface glycoprotein, EMMPRIN, stimulates production of several MMPs by fibroblasts and endothelial cells...
  39. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2004
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  40. METALLOPROTEINASES IN VENTILATOR-INDUCED LUNG INJURY
    Hussein Foda; Fiscal Year: 2003
    ..This increase in MMPs is regulated by the cytokine Extracellular matrix metalloproteinase inducer (EMMPRIN) and is caused by the exposure of lung cells to mechanical stress...
  41. NOVEL THERAPEUTIC STRATEGIES IN MYELODYSPLASTIC SYNDROME
    H Deeg; Fiscal Year: 2003
    ..Optimization of therapy, in turn, should reduce morbidity and mortality associated with MDS and improve the quality of life of patients with MDS. ..
  42. ENHANCEMENT OF HIV IMMUNOGENICITY BY INFLUENZA VIRUS
    Qizhi Yao; Fiscal Year: 2002
    ..We will be especially interested in testing in CD4+ T cell knock-out mice if such immunization can also induce antibody responses to HIV and whether HIV specific neutralizing antibody responses will also be induced. ..
  43. PERTURBATION OF HYALURONAN FUNCTION IN CANCER
    Bryan P Toole; Fiscal Year: 2010
    ..b>Emmprin (CD 147), a cell surface glycoprotein enriched in malignant tumor cells, induces hyaluronan synthesis and its ..
  44. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..abstract_text> ..
  45. Drug Sensitivity of Calcium Modulators from Brain Tumor
    Jin Ming Yang; Fiscal Year: 2006
    ..Therefore, the overall goal of this proposal is to identify new drugs for the treatment of GBM. ..
  46. Development of Motion Processing in Human Infants
    Karen Dobkins; Fiscal Year: 2008
    ..abstract_text> ..
  47. Cell Death and Clonal Survival in Myelodysplastic Syndr*
    H Deeg; Fiscal Year: 2008
    ..To achieve these objectives, we must better understand the underlying mechanisms of MDS and thereby identify ways by which the disease process can be arrested, progression prevented, and the disease hopefully be cured. ..
  48. Inhibition of Tumor Progression by Hyaluronan Oligomers
    Bryan Toole; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  49. Vaccination With Peptide-loaded alphaDC1s For Malignant Gliomas
    Hideho Okada; Fiscal Year: 2008
    ..Information from this pilot study will establish a basis to design subsequent trials with patient populations in which more significant clinical benefit might be realized. ..
  50. WT1 Expression in Patients with MDS Treated with ATG an*
    H Deeg; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. role of ubiquitinin in cancer progression
    Jin Ming Yang; Fiscal Year: 2005
    ..abstract_text> ..
  52. Role of Cystatins in Oral Cancer Metastasis
    Nadarajah Vigneswaran; Fiscal Year: 2007
    ..Insights gained from these studies will be used to design therapeutic strategies for restoring immune competence of OSCC patients to prevent and eradicate OSCC metastasis. [unreadable] [unreadable] [unreadable]..
  53. Ginkgo Biloba Enhances Therapeutic HIV Vaccination
    Qizhi Yao; Fiscal Year: 2006
    ..Furthermore, it will have the potential to initiate translational and early phase clinical trials to investigate this CAM and VLPs approach to treat HIV/AIDS and its complications. [unreadable] [unreadable]..
  54. Influenza HA in SHIV VLPS for mucosal vaccination
    Qizhi Yao; Fiscal Year: 2006
    ..abstract_text> ..
  55. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
    ..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..