CD147

Summary

Gene Symbol: CD147
Description: basigin (Ok blood group)
Alias: 5F7, CD147, EMMPRIN, EMPRIN, TCSF, basigin, OK blood group antigen, collagenase stimulatory factor, extracellular matrix metalloproteinase inducer, leukocyte activation antigen M6, tumor cell-derived collagenase stimulatory factor
Species: human
Products:     CD147

Top Publications

  1. Yurchenko V, Zybarth G, O Connor M, Dai W, Franchin G, Hao T, et al. Active site residues of cyclophilin A are crucial for its signaling activity via CD147. J Biol Chem. 2002;277:22959-65 pubmed
    ..The mechanisms underlying CyPA-mediated signaling and chemotaxis are unknown. Here, we identified CD147 as a cell surface receptor for CyPA and demonstrated that CD147 is an essential component in the CyPA-initiated ..
  2. Tang Y, Kesavan P, Nakada M, Yan L. Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN. Mol Cancer Res. 2004;2:73-80 pubmed
    ..pattern is, at least in part, regulated by tumor-stroma interaction via tumor cell-associated extracellular matrix metalloproteinase inducer (EMMPRIN)...
  3. Dai J, Dou K, Wang C, Zhao P, Lau W, Tao L, et al. The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. BMC Cancer. 2009;9:337 pubmed publisher
    HAb18G/CD147 plays pivotal roles in invasion by hepatoma cells, but the underlying mechanism remains unclear. Our previous study demonstrated that overexpression of HAb18G/CD147 promotes invasion by interacting with integrin alpha3beta1...
  4. Rucci N, Millimaggi D, Mari M, Del Fattore A, Bologna M, Teti A, et al. Receptor activator of NF-kappaB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147. Cancer Res. 2010;70:6150-60 pubmed publisher
    Breast cancer shows a strong predilection to metastasize to bone. Cell surface glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN)/CD147 induces metalloproteinases (MMP) and vascular endothelial growth factor (VEGF), ..
  5. Pons M, Cousins S, Alcazar O, Striker G, Marin Castano M. Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degener. Am J Pathol. 2011;178:2665-81 pubmed publisher
    ..RPE-derived matrix metalloproteinase (MMP)-2, MMP-14, and basigin (BSG) are major enzymes involved in the maintenance of ECM turnover...
  6. Seizer P, Schonberger T, Schött M, Lang M, Langer H, Bigalke B, et al. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. Atherosclerosis. 2010;209:51-7 pubmed publisher
    ..Thus, we investigated the role of EMMPRIN (CD147) and its ligand cyclophilin A (CyPA) during foam cell formation originating from both monocytes/..
  7. Bougatef F, Menashi S, Khayati F, Naimi B, Porcher R, Podgorniak M, et al. EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. PLoS ONE. 2010;5:e12265 pubmed publisher
    b>EMMPRIN's expression in melanoma tissue was reported to be predictive of poor prognosis...
  8. Yurchenko V, Pushkarsky T, Li J, Dai W, Sherry B, Bukrinsky M. Regulation of CD147 cell surface expression: involvement of the proline residue in the CD147 transmembrane domain. J Biol Chem. 2005;280:17013-9 pubmed
    CD147, also known as extracellular matrix metalloproteinase inducer, is a regulator of matrix metalloproteinase production and serves as a signaling receptor for extracellular cyclophilins...
  9. Liang Y, He H, Han Z, Bi X, Dai Q, Ye Y, et al. CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value. Cancer Invest. 2009;27:788-93 pubmed publisher
    To investigate the clinicopathologic characteristics of extracellular matrix (ECM) metalloproteinase inducer (CD147) and vascular endothelial growth factor (VEGF) expression in advanced renal cell carcinoma (RCC), and to evaluate the ..

More Information

Publications160 found, 100 shown here

  1. Berditchevski F, Chang S, Bodorova J, Hemler M. Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6. J Biol Chem. 1997;272:29174-80 pubmed
    ..These 16 included 15 monoclonal antibodies recognizing EMMPRIN/basigin/OX-47/M6, a 45-55-kDa transmembrane protein with two immunoglobulin domains...
  2. Taylor P, Woodfield R, Hodgkin M, Pettitt T, Martin A, Kerr D, et al. Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway. Oncogene. 2002;21:5765-72 pubmed
    ..In this report we demonstrate that breast cancer cells in culture release apparently full length soluble EMMPRIN that promotes the release of pro-MMP2 from fibroblasts...
  3. Zhao Y, Chen S, Gou W, Niu Z, Zhao S, Xiao L, et al. The role of EMMPRIN expression in ovarian epithelial carcinomas. Cell Cycle. 2013;12:2899-913 pubmed publisher
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN) was reported to involve in the invasion and metastasis of malignancies by regulating the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) ..
  4. Qin Z, Dai L, Bratoeva M, Slomiany M, Toole B, Parsons C. Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphoma. Leukemia. 2011;25:1598-609 pubmed publisher
    ..The membrane-bound glycoprotein emmprin (CD147) enhances chemoresistance in tumors through effects on transporter expression, trafficking and ..
  5. Tian L, Zhang Y, Chen Y, Cai M, Dong H, Xiong L. EMMPRIN is an independent negative prognostic factor for patients with astrocytic glioma. PLoS ONE. 2013;8:e58069 pubmed publisher
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as CD147, is a member of the immunoglobulin superfamily that is present on the surface of tumor cells and stimulates adjacent fibroblasts to produce matrix ..
  6. Cui H, Guo T, Wang S, Zhao P, Dong Z, Zhang Y, et al. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Biochem Biophys Res Commun. 2012;419:517-22 pubmed publisher
    HAb18G/CD147 is a transmembrane glycoprotein of the immunoglobulin superfamily (IgSF) and is reported to be correlated with invasion and metastasis of many cancers...
  7. Solstad T, Bains S, Landskron J, Aandahl E, Thiede B, Tasken K, et al. CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells. Blood. 2011;118:5141-51 pubmed publisher
    ..CD147 (Basigin or Emmprin) divided CD4(+)CD25(+) cells into distinct subsets...
  8. Su J, Chen X, Kanekura T. A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis. Cancer Lett. 2009;273:140-7 pubmed publisher
    ..Our previous results revealed that the over-expressed CD147/basigin plays a critical role in malignant melanoma (MM) invasiveness, metastasis and angiogenesis; CD147 has also been ..
  9. Yan L, Zucker S, Toole B. Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression. Thromb Haemost. 2005;93:199-204 pubmed
    b>Emmprin (basigin;CD147) is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of malignant tumour cells...
  10. Wang L, Wu G, Yu L, Yuan J, Fang F, Zhai Z, et al. Inhibition of CD147 expression reduces tumor cell invasion in human prostate cancer cell line via RNA interference. Cancer Biol Ther. 2006;5:608-14 pubmed
    CD147, also named extracelluar matrix metalloproteinase inducer (EMMPRIN), has been proved to be involved in the invasion and metastasis processes of tumor cells in many types of cancers...
  11. Piao S, Zhao S, Guo F, Xue J, Yao G, Wei Z, et al. Increased expression of CD147 and MMP-9 is correlated with poor prognosis of salivary duct carcinoma. J Cancer Res Clin Oncol. 2012;138:627-35 pubmed publisher
    The aim of this study was to investigate expression of CD147 and MMP-9 in salivary duct carcinoma (SDC) so as to determine whether these two genes may be correlated with poor prognosis of SDC.
  12. Lee C, Lam M, Lam K, Leung C, Pang R, Chu I, et al. Identification of CD147 (basigin) as a mediator of trophoblast functions. Hum Reprod. 2013;28:2920-9 pubmed publisher
    Does CD147 regulate trophoblast functions in vitro? CD147 exists as a receptor complex on human trophoblast and regulates the implantation, invasion and differentiation of trophoblast...
  13. Grass G, Tolliver L, Bratoeva M, Toole B. CD147, CD44, and the epidermal growth factor receptor (EGFR) signaling pathway cooperate to regulate breast epithelial cell invasiveness. J Biol Chem. 2013;288:26089-104 pubmed publisher
    The immunoglobulin superfamily glycoprotein CD147 (emmprin; basigin) is associated with an invasive phenotype in various types of cancers, including malignant breast cancer...
  14. Kong L, Liao C, Zhang Y, Xu J, Li Y, Huang W, et al. A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis. Cancer Res. 2014;74:3764-78 pubmed publisher
    Breast cancer is the most common cancer in women for which the metastatic process is still poorly understood. CD147 is upregulated in breast cancer and has been associated with tumor progression, but little is known about its regulatory ..
  15. Du Z, Hu C, Shao Q, Huang M, Kou C, Zhu X, et al. Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cell migration and correlated with poor prognosis of the patients. Int J Cancer. 2009;125:1832-41 pubmed publisher
    Expression of caveolin-1 (Cav-1) and extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) and their prognostic significance were analyzed in archive NPC samples. Cav-1 and CD147 were overexpressed in 49.48% (96/194) and 59...
  16. Fu J, Fu J, Chen X, Zhang Y, Gu H, Bai Y. CD147 and VEGF co-expression predicts prognosis in patients with acute myeloid leukemia. Jpn J Clin Oncol. 2010;40:1046-52 pubmed publisher
    To investigate the possible role of CD147 and vascular endothelial growth factor in progression and prognosis of acute myeloid leukemia...
  17. Wu J, Ru N, Zhang Y, Li Y, Wei D, Ren Z, et al. HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-? signaling and is transcriptionally regulated by Slug. Oncogene. 2011;30:4410-27 pubmed publisher
    ..HAb18G/CD147, which belongs to the CD147 family, is an HCC-associated antigen that has a crucial role in tumor invasion and ..
  18. Seizer P, Borst O, Langer H, Bültmann A, Münch G, Herouy Y, et al. EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost. 2009;101:682-6 pubmed
    The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147, basigin) is an immunoglobulin-like receptor expressed in various cell types...
  19. Chen Y, Zhang H, Gou X, Horikawa Y, Xing J, Chen Z. Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis. Cancer Lett. 2009;278:113-21 pubmed publisher
    Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells ..
  20. Yang M, Yuan Y, Zhang H, Yan M, Wang S, Feng F, et al. Prognostic significance of CD147 in patients with glioblastoma. J Neurooncol. 2013;115:19-26 pubmed publisher
    CD147, also known as extracellular matrix metalloproteinase inducer, is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin superfamily...
  21. Zhong W, Han Z, He H, Bi X, Dai Q, Zhu G, et al. CD147, MMP-1, MMP-2 and MMP-9 protein expression as significant prognostic factors in human prostate cancer. Oncology. 2008;75:230-6 pubmed publisher
    b>CD147 and MMPs have been demonstrated to be involved in tumor invasion and angiogenesis...
  22. Wang C, Dai J, Wang L, Jia J, Zheng Z, Ding J, et al. Expression of CD147 (EMMPRIN) on neutrophils in rheumatoid arthritis enhances chemotaxis, matrix metalloproteinase production and invasiveness of synoviocytes. J Cell Mol Med. 2011;15:850-60 pubmed publisher
    ..The present article studied the expression of CD147 on neutrophils and its potential role in neutrophil chemotaxis, MMPs production and the invasiveness of fibroblast-..
  23. Kirk P, Wilson M, Heddle C, Brown M, Barclay A, Halestrap A. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 2000;19:3896-904 pubmed
    b>CD147 is a broadly expressed plasma membrane glycoprotein containing two immunoglobulin-like domains and a single charge-containing transmembrane domain...
  24. Zhu P, Ding J, Zhou J, Dong W, Fan C, Chen Z. Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production. Arthritis Res Ther. 2005;7:R1023-33 pubmed
    ..molecules, including IL-1 and tumor necrosis factor-alpha, but there have been very few reports on the role of CD147 in RA...
  25. Kanyenda L, Verdile G, Boulos S, Krishnaswamy S, Taddei K, Meloni B, et al. The dynamics of CD147 in Alzheimer's disease development and pathology. J Alzheimers Dis. 2011;26:593-605 pubmed publisher
    CD147, also known as basigin, EMMPRIN, neurothelin, TCSF, M6, HT7, OX47, or gp42, is a transmembrane glycoprotein of the immunoglobulin super-family...
  26. Maeda Hori M, Kosugi T, Kojima H, Sato W, Inaba S, Maeda K, et al. Plasma CD147 reflects histological features in patients with lupus nephritis. Lupus. 2014;23:342-52 pubmed publisher
    A glycosylated transmembrane protein, CD147, has been implicated in regulating lymphocyte responsiveness and leukocyte recruitment...
  27. Muramatsu T, Miyauchi T. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. Histol Histopathol. 2003;18:981-7 pubmed publisher
    b>Basigin (Bsg) is a transmembrane glycoprotein with two immunoglobulin-like domains, and forms a family with embigin and neuroplastin. In these proteins a conserved glutamic acid is present in the middle for the transmembrane domain...
  28. Tang W, Hemler M. Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering. J Biol Chem. 2004;279:11112-8 pubmed
    b>CD147, a regulator of matrix metalloproteinase (MMP) production, showed highly specific association with caveolin-1 on the surface of multiple cell types...
  29. Sluijter J, Pulskens W, Schoneveld A, Velema E, Strijder C, Moll F, et al. Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteina. Stroke. 2006;37:235-9 pubmed
    We studied matrix metalloproteinases (MMP) 2, 8, and 9 and extracellular matrix metalloproteinase inducer (EMMPRIN) levels in relation to carotid atherosclerotic plaque characteristics...
  30. Zheng H, Wang W, Xu X, Xia P, Yu M, Sugiyama T, et al. Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level. J Cancer Res Clin Oncol. 2011;137:585-96 pubmed publisher
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN) was reported to involve in the invasion and metastasis of malignancies by regulating the expression of vascular endothelial growth factor (VEGF) in stromal and cancer cells...
  31. Yu X, Jiang J, Li L, Feng Q, Xu J, Chen Z. The glycosylation characteristic of hepatoma-associated antigen HAb18G/CD147 in human hepatoma cells. Int J Biochem Cell Biol. 2006;38:1939-45 pubmed
    HAb18G/CD147 is a highly glycosylated transmembrane protein belonging to the immunoglobulin superfamily. Our previous studies have demonstrated that overexpressing HAb18G/CD147 enhances the metastatic potentials of human hepatoma cells...
  32. Ruiz S, Castro Castro A, Bustelo X. CD147 inhibits the nuclear factor of activated T-cells by impairing Vav1 and Rac1 downstream signaling. J Biol Chem. 2008;283:5554-66 pubmed
    b>CD147 is a transmembrane protein that plays crucial roles in the development and function of the reproductive, visual, and nervous systems. CD147 also exerts positive and negative actions in T-cells by still obscure mechanisms...
  33. Han Z, Bi X, Qin W, He H, Dai Q, Zou J, et al. CD147 expression indicates unfavourable prognosis in prostate cancer. Pathol Oncol Res. 2009;15:369-74 pubmed publisher
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN, also named as CD147) is a multifunctional membrane glycoprotein over-expressed in many kinds of human solid tumors...
  34. Moonsom S, Tayapiwatana C, Wongkham S, Kongtawelert P, Kasinrerk W. A Competitive ELISA for quantifying serum CD147: reduction of soluble CD147 levels in cancer patient sera. Hybridoma (Larchmt). 2010;29:45-52 pubmed publisher
    CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) is a cell surface glycoprotein that displays increased expression in many cancers. It has been previously demonstrated to participate in cancer metastasis and progression...
  35. Wittschieber D, Stenzinger A, Klauschen F, Stephan C, Jung K, Erbersdobler A, et al. Decreased RECK and Increased EMMPRIN expression in urothelial carcinoma of the bladder are associated with tumor aggressiveness. Pathobiology. 2011;78:123-31 pubmed publisher
    ..The MMP repressor RECK and the MMP activator EMMPRIN regulate the invasive potential by metalloproteinase-induced stromal degradation...
  36. Yang J, Xu Z, Wu H, Zhu H, Wu X, Hait W. Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol Cancer Res. 2003;1:420-7 pubmed
    ..to clarify the mechanism(s) underlying these observations, we studied the expression of extracellular matrix metalloproteinase inducer (EMMPRIN), a glycoprotein enriched on the surface of tumor cells that can stimulate the ..
  37. Tang W, Chang S, Hemler M. Links between CD147 function, glycosylation, and caveolin-1. Mol Biol Cell. 2004;15:4043-50 pubmed
    Cell surface CD147 shows remarkable variations in size (31-65 kDa) because of heterogeneous N-glycosylation, with the most highly glycosylated forms functioning to induce matrix metalloproteinase (MMP) production...
  38. Ochrietor J, Moroz T, van Ekeris L, Clamp M, Jefferson S, deCarvalho A, et al. Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Invest Ophthalmol Vis Sci. 2003;44:4086-96 pubmed
    5A11/Basigin has recently been identified as a critical glycoprotein for full maturity and function of the mouse retina. However, the biological function of 5A11/Basigin has yet to be determined...
  39. Gabison E, Mourah S, Steinfels E, Yan L, Hoang Xuan T, Watsky M, et al. Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol. 2005;166:209-19 pubmed
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN) was originally identified on the tumor cell surface as an inducer of matrix metalloproteinase (MMP) production in neighboring fibroblasts...
  40. Tan H, Ye K, Wang Z, Tang H. CD147 expression as a significant prognostic factor in differentiated thyroid carcinoma. Transl Res. 2008;152:143-9 pubmed publisher
    b>CD147 is 1 of the molecules involved in regulating the expression of matrix metalloproteinases (MMPs)...
  41. Kong L, Liao C, Chen L, Yang H, Zhang S, Zhang Z, et al. Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular carcinoma. J Cell Mol Med. 2011;15:1415-28 pubmed publisher
    b>CD147 is a transmembrane glycoprotein overexpressed in human hepatocellular carcinoma (HCC) which could promote HCC progression and metastasis. Promoter methylation is one of the most important processes in gene regulation...
  42. Arendt B, Walters D, Wu X, Tschumper R, Huddleston P, Henderson K, et al. Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation. Leukemia. 2012;26:2286-96 pubmed publisher
    ..Our studies show for the first time that the CD147 molecule (extracellular matrix metalloproteinase inducer) may be having an important biological role in MM...
  43. Huang W, Luo W, Zhu P, Tang J, Yu X, Cui H, et al. Modulation of CD147-induced matrix metalloproteinase activity: role of CD147 N-glycosylation. Biochem J. 2013;449:437-48 pubmed publisher
    ..b>CD147 is a tumour-associated antigen that plays a key regulatory role for MMP activities...
  44. Yang J, O Neill P, Jin W, Foty R, Medina D, Xu Z, et al. Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem. 2006;281:9719-27 pubmed
    Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, promotes invasion, metastasis, and growth and survival ..
  45. Li Y, Xu J, Chen L, Chen L, Zhong W, Zhang Z, et al. HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology. 2009;54:677-87 pubmed publisher
    To evaluate HAb18G/CD147 as a cancer-associated biomarker using its monoclonal antibody HAb18...
  46. Wang B, Xu Y, He B, Pan Y, Zhang L, Zhu C, et al. RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro. J Exp Clin Cancer Res. 2010;29:61 pubmed publisher
    b>CD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily. CD147 has been implicated in numerous physiological and pathological activities...
  47. Redzic J, Armstrong G, Isern N, Jones D, Kieft J, Eisenmesser E. The retinal specific CD147 Ig0 domain: from molecular structure to biological activity. J Mol Biol. 2011;411:68-82 pubmed publisher
    b>CD147 is a type I transmembrane protein that is involved in inflammatory diseases, cancer progression, and multiple human pathogens utilize CD147 for efficient infection...
  48. Huang Z, Wang L, Wang Y, Zhuo Y, Li H, Chen J, et al. Overexpression of CD147 contributes to the chemoresistance of head and neck squamous cell carcinoma cells. J Oral Pathol Med. 2013;42:541-6 pubmed publisher
    ..However, the mechanisms underlying cisplatin resistance is still largely unrevealed. In this study, we found that CD147 was overexpressed in cisplatin-resistant HNSCC cell lines...
  49. Reimers N, Zafrakas K, Assmann V, Egen C, Riethdorf L, Riethdorf S, et al. Expression of extracellular matrix metalloproteases inducer on micrometastatic and primary mammary carcinoma cells. Clin Cancer Res. 2004;10:3422-8 pubmed
    b>EMMPRIN (extracellular matrix metalloprotease inducer) is a glycosylated member of the immunoglobulin superfamily known to stimulate the production of matrix metalloproteases (MMPs) 1, 2, and 3 and MT1-MMP in peritumoral fibroblasts...
  50. Millimaggi D, Mari M, D Ascenzo S, Carosa E, Jannini E, Zucker S, et al. Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells. Neoplasia. 2007;9:349-57 pubmed
    ..Several studies have demonstrated that CD147/extracellular MMP inducer, a membrane-spanning molecule highly expressed in tumor cells, may be involved in the ..
  51. Zeng H, Qu Y, Liang A, Deng A, Zhang W, Xiu B, et al. Expression of CD147 in advanced non-small cell lung cancer correlated with cisplatin-based chemotherapy resistance. Neoplasma. 2011;58:449-54 pubmed
    b>CD147, a widely expressed cell surface glycoprotein in cancer, is associated with tumor invasiveness and chemotherapy resistance. Recently, CD147 is also regarded as a potential therapeutic target for cancer therapy...
  52. Xue Y, Lu Q, Sun Z. CD147 overexpression is a prognostic factor and a potential therapeutic target in bladder cancer. Med Oncol. 2011;28:1363-72 pubmed publisher
    CD147, also named extracellular matrix metalloproteinase inducer (EMMPRIN), has been shown to be involved in the progression of malignancy by regulating expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases ..
  53. Grupp K, Höhne T, Prien K, Hube Magg C, Tsourlakis M, Sirma H, et al. Reduced CD147 expression is linked to ERG fusion-positive prostate cancers but lacks substantial impact on PSA recurrence in patients treated by radical prostatectomy. Exp Mol Pathol. 2013;95:227-34 pubmed publisher
    The extracellular matrix metalloproteinase inducer CD147 has been suggested as a prognostic marker in prostate cancer...
  54. Egawa N, Koshikawa N, Tomari T, Nabeshima K, Isobe T, Seiki M. Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells. J Biol Chem. 2006;281:37576-85 pubmed
    ..b>Extracellular matrix metalloproteinase inducer (EMMPRIN) is a multifunctional glycoprotein that has two Ig-like domains in its extracellular ..
  55. Pértega Gomes N, Vizcaíno J, Miranda Gonçalves V, Pinheiro C, Silva J, Pereira H, et al. Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer. 2011;11:312 pubmed publisher
    ..value of monocarboxylate transporters (MCTs) expression, namely MCT1, MCT2 and MCT4, together with CD147 and gp70 as MCT1/4 and MCT2 chaperones, respectively, in prostate carcinoma...
  56. Biswas C, Zhang Y, DeCastro R, Guo H, Nakamura T, Kataoka H, et al. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res. 1995;55:434-9 pubmed
    Tumor cell-derived collagenase stimulatory factor, renamed extracellular matrix metalloproteinase inducer (EMMPRIN), is a M(r) approximately 58,000 glycoprotein which is located on the outer surface of human tumor cells and which ..
  57. Li H, Xie D, Shen X, Li H, Zeng H, Zeng Y. Clinicopathological significance of expression of paxillin, syndecan-1 and EMMPRIN in hepatocellular carcinoma. World J Gastroenterol. 2005;11:1445-51 pubmed
    To evaluate the relationship of expression of paxillin, syndecan-1 and EMMPRIN proteins with clinicopathological features in hepatocellular carcinoma (HCC). Fifty-one patients who underwent HCC resection were recruited in the study...
  58. Zhu P, Lu N, Shi Z, Zhou J, Wu Z, Yang Y, et al. CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes. Arthritis Res Ther. 2006;8:R44 pubmed
    ..The present article studied the expression of CD147, also called extracellular matrix metalloproteinase inducer, on monocytes/macrophages and FLS from RA patients and its potential role in enhancing MMPs ..
  59. Riethdorf S, Reimers N, Assmann V, Kornfeld J, Terracciano L, Sauter G, et al. High incidence of EMMPRIN expression in human tumors. Int J Cancer. 2006;119:1800-10 pubmed
    b>Extracellular matrix metalloproteinase inducer expressed by tumor cells stimulates peritumoral fibroblasts to produce matrix metalloproteinases, thus contributing to tumor invasion and metastasis...
  60. Zhu C, Pan Y, He B, Wang B, Xu Y, Qu L, et al. Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncol Rep. 2011;25:425-32 pubmed publisher
    CD147, also named extracelluar matrix metalloproteinase inducer (EMMPRIN), is a member of the immunoglobulin family and a glycoprotein enriched on the surface of tumor cells, which promotes invasion, metastasis, growth and survival of ..
  61. Tyler R, Pearce M, Shaler T, Olzmann J, Greenblatt E, Kopito R. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. Mol Biol Cell. 2012;23:4668-78 pubmed publisher
    ..In this study, we used mass spectrometry to identify core-glycoslyated CD147 (CD147(CG)) as an endogenous substrate of the ERAD system that accumulates in a complex with OS-9 following SEL1L ..
  62. Guo H, Majmudar G, Jensen T, Biswas C, Toole B, Gordon M. Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. Gene. 1998;220:99-108 pubmed
    EMMPRIN (extracellular matrix metalloproteinase inducer) also known as CD147 and basigin, is a member of the immunoglobulin family that is present on the surface of tumor cells and stimulates nearby fibroblasts to synthesize matrix ..
  63. Jin J, Yao C, Loh S, Cheng M, Hsieh D, Bai C. Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. Int J Gynecol Pathol. 2006;25:140-6 pubmed
    ..that are thought to be induced by tumor cell-derived extracellular matrix metalloprotease inducer (EMMPRIN) in surrounding fibroblasts. We hypothesized that EMMPRIN isoverexpressed in ovary tumors...
  64. Gou X, Ru Q, Zhang H, Chen Y, Li L, Yang H, et al. HAb18G/CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 down-regulation. Cancer Sci. 2009;100:837-43 pubmed publisher
    HAb18G/CD147, a transmembrane glycoprotein highly expressed in various types of malignant cells, mainly functions as an inducer of matrix metalloproteinases to promote tumor growth, invasion and metastasis...
  65. Schulz C, von Brühl M, Barocke V, Cullen P, Mayer K, Okrojek R, et al. EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall. J Thromb Haemost. 2011;9:1007-19 pubmed publisher
    ..To investigate the role of the extracellular matrix metalloproteinase inducer (EMMPRIN) in platelet-monocyte interactions...
  66. Kanekura T, Chen X, Kanzaki T. Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer. 2002;99:520-8 pubmed
    EMMPRIN, which is identical to human basigin (CD147), interacts with fibroblasts and stimulates expression of MMPs, which play an important role in tumor invasiveness and metastasis...
  67. Liu F, Cui L, Zhang Y, Chen L, Wang Y, Fan Y, et al. Expression of HAb18G is associated with tumor progression and prognosis of breast carcinoma. Breast Cancer Res Treat. 2010;124:677-88 pubmed publisher
    ..In conclusion, this study suggests that HAb18G expression is associated with BC progression and prognosis. Further evaluation of this new marker in breast cancer is indicated. ..
  68. DeCastro R, Zhang Y, Guo H, Kataoka H, Gordon M, Toole B, et al. Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer. J Invest Dermatol. 1996;106:1260-5 pubmed
    ..We have previously isolated and purified a tumor cell surface protein, EMMPRIN (extracellular matrix metalloproteinase inducer), which stimulates production of interstitial collagenase, gelatinase A, and stromelysin-1 by ..
  69. Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Miwa S, et al. Upregulated EMMPRIN/CD147 might contribute to growth and angiogenesis of gastric carcinoma: a good marker for local invasion and prognosis. Br J Cancer. 2006;95:1371-8 pubmed
    ..Extracellular MMP inducer (EMMPRIN) was reported to involve in the progression of malignancies by regulating expression of VEGF and MMPs in stromal ..
  70. Belton R, Chen L, Mesquita F, Nowak R. Basigin-2 is a cell surface receptor for soluble basigin ligand. J Biol Chem. 2008;283:17805-14 pubmed publisher
    ..The immunoglobulin superfamily protein basigin (EMMPRIN/CD147) is a cell surface glycoprotein expressed by tumor cells that stimulates matrix metalloproteinase ..
  71. Wu Y, Zhou X, Zheng P. Involvement of CD147 isoform?4 in the proliferation of SiHa cells: a possible molecular mechanism of cervical cancer. Oncol Rep. 2011;26:717-24 pubmed publisher
    b>CD147, a multifunction glycoprotein of the immuno-globulin family, is associated with many types of tumors, and the overexpression of CD147 can enhance malignancy. However, the role of CD147 in cervical cancer remains unclear...
  72. Tang J, Guo Y, Zhang Y, Yu X, Li L, Huang W, et al. CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma. Cell Death Differ. 2012;19:1779-90 pubmed publisher
    ..However, tumor-specific UPR transducers are largely unknown. In the present study, we identified CD147, a cancer biomarker, as an UPR inducer in hepatocellular carcinoma (HCC)...
  73. Li H, Chen J, He M, Hui X, Cai B, Li Y. [Expression of CD147 and MMP-2 in human gliomas and its correlations with prognosis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007;38:396-9 pubmed
    To investigate the expressions of CD147 and MMP-2 in human gliomas and to study the relationship between their expression and prognosis...
  74. Hanata K, Yamaguchi N, Yoshikawa K, Mezaki Y, Miura M, Suzuki S, et al. Soluble EMMPRIN (extra-cellular matrix metalloproteinase inducer) stimulates the migration of HEp-2 human laryngeal carcinoma cells, accompanied by increased MMP-2 production in fibroblasts. Arch Histol Cytol. 2007;70:267-77 pubmed
    ..A glycoprotein highly expressed on the cancer-cell membrane, EMMPRIN (extra-cellular matrix metalloproteinase inducer), exhibits the potential role of the MMP inductor in stromal ..
  75. Kasinrerk W, Fiebiger E, Stefanova I, Baumruker T, Knapp W, Stockinger H. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. J Immunol. 1992;149:847-54 pubmed
    ..sequence indicates that M6 Ag is a member of the Ig superfamily and the species homologue of rat OX-47 Ag, mouse basigin (gp42), and chicken HT7 molecule...
  76. Tang Y, Nakada M, Rafferty P, Laraio J, McCabe F, Millar H, et al. Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3K-Akt signaling pathway. Mol Cancer Res. 2006;4:371-7 pubmed
    Extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN) is a cell surface glycoprotein overexpressed in many solid tumors...
  77. Zhu H, Zhao J, Zhu B, Collazo J, Gal J, Shi P, et al. EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer. Prostate. 2012;72:72-81 pubmed publisher
    ..We identified EMMPRIN (extracellular matrix metalloproteinase inducer) as a key candidate and shRNA functional approaches were subsequently applied to determine the ..
  78. Dai L, Guinea M, Slomiany M, Bratoeva M, Grass G, Tolliver L, et al. CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. Am J Pathol. 2013;182:577-85 pubmed publisher
    CD147 (alias emmprin or basigin), an integral plasma membrane glycoprotein and a member of the Ig superfamily, is widespread in normal tissues, but highly up-regulated in many types of malignant cancer cells...
  79. Grass G, Dai L, Qin Z, Parsons C, Toole B. CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance. Adv Cancer Res. 2014;123:351-73 pubmed publisher
    ..CD147 (emmprin; basigin) is a member of the Ig superfamily that has also been strongly implicated in chemoresistance and invasiveness...
  80. Madigan M, Kingsley E, Cozzi P, Delprado W, Russell P, Li Y. The role of extracellular matrix metalloproteinase inducer protein in prostate cancer progression. Cancer Immunol Immunother. 2008;57:1367-79 pubmed publisher
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) is a multifunctional membrane glycoprotein overexpressed in many solid tumors, and involved in tumor invasion and angiogenesis...
  81. Huang Z, Huang H, Li H, Chen W, Pan C. EMMPRIN expression in tongue squamous cell carcinoma. J Oral Pathol Med. 2009;38:518-23 pubmed publisher
    b>Extracellular matrix metalloproteinase inducer (EMMPRIN) is identified as a tumor-cell membrane protein that stimulates matrix metalloproteinases (MMPs) production...
  82. Zhang W, Zhao P, Xu X, Cai L, Song Z, Cao D, et al. Annexin A2 promotes the migration and invasion of human hepatocellular carcinoma cells in vitro by regulating the shedding of CD147-harboring microvesicles from tumor cells. PLoS ONE. 2013;8:e67268 pubmed publisher
    ..ANXA2 was also found to be co-localized and co-immunoprecipitated with CD147. Further investigation revealed that the expression of ANXA2 in HCC cells affected the shedding of CD147-harboring ..
  83. Schmidt R, Bültmann A, Ungerer M, Joghetaei N, Bülbül O, Thieme S, et al. Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Circulation. 2006;113:834-41 pubmed
    ..It has been suggested that, on tumor cells, the extracellular MMP inducer (EMMPRIN) is involved in MMP synthesis by as yet unknown mechanisms...
  84. Song F, Zhang X, Ren X, Zhu P, Xu J, Wang L, et al. Cyclophilin A (CyPA) induces chemotaxis independent of its peptidylprolyl cis-trans isomerase activity: direct binding between CyPA and the ectodomain of CD147. J Biol Chem. 2011;286:8197-203 pubmed publisher
    ..has been identified that the chemotaxis activity of CyPA is mediated through its cell surface signaling receptor CD147, the role of CyPA PPIase activity in this process is disputable, and the underlying molecular mechanism is still ..
  85. Zhong W, Liang Y, Lin S, Li L, He H, Bi X, et al. Expression of CD147 is associated with prostate cancer progression. Int J Cancer. 2012;130:300-8 pubmed publisher
    ..b>Extracellular matrix metalloproteinase inducer (CD147) has been demonstrated to be involved in tumor invasion, metastasis, growth and ..
  86. Grass G, Bratoeva M, Toole B. Regulation of invadopodia formation and activity by CD147. J Cell Sci. 2012;125:777-88 pubmed publisher
    ..CD147 (emmprin, basigin), an immunoglobulin superfamily protein that is associated with tumor invasion and metastasis, induces the ..
  87. Stenzinger A, Wittschieber D, von Winterfeld M, Goeppert B, Kamphues C, Weichert W, et al. High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer. Hum Pathol. 2012;43:1471-81 pubmed publisher
    ..b>Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that activates matrix metalloproteinases, a group of ..
  88. Sweeny L, Liu Z, Bush B, Hartman Y, Zhou T, Rosenthal E. CD147 and AGR2 expression promote cellular proliferation and metastasis of head and neck squamous cell carcinoma. Exp Cell Res. 2012;318:1788-98 pubmed publisher
    ..b>CD147 is a transmembrane glycoprotein known to induce cell migration and invasion...
  89. Suzuki S, Sato M, Senoo H, Ishikawa K. Direct cell-cell interaction enhances pro-MMP-2 production and activation in co-culture of laryngeal cancer cells and fibroblasts: involvement of EMMPRIN and MT1-MMP. Exp Cell Res. 2004;293:259-66 pubmed
    ..Recently, EMMPRIN/CD147, which is a member of immunoglobulin superfamily, has been reported to be highly expressed in tumor cells ..
  90. Ju X, Yang J, Zhou X, Li Z, Wu X. EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer. Clin Cancer Res. 2008;14:494-501 pubmed publisher
    Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN), a member of the immunoglobulin family and a glycoprotein enriched on the surface of many types of tumor cells, has been reported to be linked to invasion, ..
  91. Liao C, Kong L, Song F, Xing J, Wang L, Sun Z, et al. Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. Mol Cell Biol. 2011;31:2591-604 pubmed publisher
    b>Basigin, which has four isoforms, plays an important role in invasion of hepatocellular carcinoma (HCC)...
  92. Li L, Tang W, Wu X, Karnak D, Meng X, Thompson R, et al. HAb18G/CD147 promotes pSTAT3-mediated pancreatic cancer development via CD44s. Clin Cancer Res. 2013;19:6703-15 pubmed publisher
    ..However, therapeutically targeting STAT3 has failed clinically. We previously identified HAb18G/CD147 as an effective target for cancer treatment...