CD14

Summary

Gene Symbol: CD14
Description: CD14 molecule
Alias: monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein
Species: human
Products:     CD14

Top Publications

  1. von Hahn T, Halangk J, Witt H, Neumann K, Müller T, Puhl G, et al. Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease. Scand J Gastroenterol. 2008;43:584-92 pubmed publisher
    The lipopolysaccharide (LPS)-triggered release of inflammatory cytokines from Kupffer cells is mediated via the CD14/TLR4 receptor complex...
  2. Fallavena P, Borges T, Paskulin D, Paludo F, Goetze T, de Oliveira J, et al. The influences of CD14 -260C>T polymorphism on survival in ICU critically ill patients. Immunol Invest. 2009;38:797-811 pubmed publisher
    In order to analyze the effect of the two different versions of the cluster of differentiation 14 (CD14) receptor recognizing gene on survival, we determined the -260C>T single nucleotide polymorphism (SNP) frequencies in 514 ..
  3. Zhang Y, Tian C, Zhang J, Li X, Wan H, He C, et al. The -159C/T polymorphism in the CD14 gene and the risk of asthma: a meta-analysis. Immunogenetics. 2011;63:23-32 pubmed publisher
    The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results...
  4. Bottema R, Reijmerink N, Kerkhof M, Koppelman G, Stelma F, Gerritsen J, et al. Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study. Eur Respir J. 2008;32:593-602 pubmed publisher
    ..Haplotype-tagging polymorphisms in the genes interleukin (IL)13 and CD14 were genotyped in 3,062 children from the following birth cohorts: the Prevention and Incidence of Asthma and Mite ..
  5. Meiler C, Muhlbauer M, Johann M, Hartmann A, Schnabl B, Wodarz N, et al. Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection. World J Gastroenterol. 2005;11:6031-7 pubmed
    ..Recently, a C-T (-159) polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver ..
  6. Yuan F, Marks K, Wong M, Watson S, de Leon E, McIntyre P, et al. Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection. Immunol Cell Biol. 2008;86:268-70 pubmed publisher
    ..study, polymorphisms in several candidate genes, including TLR2-Arg/Gln753, TLR4-Asp/Gly299, TLR4-Thr/Ile399, CD14-159C/T and FcgammaRIIA-R/H131, were examined in 85 children with pneumococcal sepsis as an invasive pneumococcal ..
  7. Mertens J, Bregadze R, Mansur A, Askar E, Bickeböller H, Ramadori G, et al. Functional impact of endotoxin receptor CD14 polymorphisms on transcriptional activity. J Mol Med (Berl). 2009;87:815-24 pubmed publisher
    The polymorphism rs2569190 within the CD14 endotoxin (lipopolysaccharide, LPS) receptor gene is associated with various disease conditions that are assumed to rely on endotoxin sensitivity...
  8. Areeshi M, Mandal R, Panda A, Bisht S, Haque S. CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis. PLoS ONE. 2013;8:e64747 pubmed publisher
    Cluster of differentiation 14 (CD14) gene is an important component of the human innate immune system and its role in tuberculosis (TB) has been sparsely documented...
  9. Wiertsema S, Khoo S, Baynam G, Veenhoven R, Laing I, Zielhuis G, et al. Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses. Clin Vaccine Immunol. 2006;13:892-7 pubmed
    ..b>CD14 plays key roles in innate immunity, including in defense against pathogens associated with otitis media, a major ..

More Information

Publications93

  1. Smit L, Bongers S, Ruven H, Rijkers G, Wouters I, Heederik D, et al. Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case-control study. Clin Exp Allergy. 2007;37:1602-8 pubmed
    ..To study potential associations between single nucleotide polymorphisms (SNPs) in CD14, Toll-like receptor 2 (TLR2), and TLR4 genes, and atopy and new-onset asthma in young farmers...
  2. Lachheb J, Dhifallah I, Chelbi H, Hamzaoui K, Hamzaoui A. Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in Tunisian children. Tissue Antigens. 2008;71:417-25 pubmed publisher
    Many studies have shown the implication of CD14 and toll-like receptors (TLRs) 2, 4 and 9 in the pathogenesis of asthma or atopy...
  3. Bjørnvold M, Munthe Kaas M, Egeland T, Joner G, Dahl Jørgensen K, Njølstad P, et al. A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma. Genes Immun. 2009;10:181-7 pubmed publisher
    ..Toll-like receptors (TLRs) and CD14 are members of this family and could represent a molecular link between microbial infections and immune-mediated ..
  4. Gu W, Dong H, Jiang D, Zhou J, Du D, Gao J, et al. Functional significance of CD14 promoter polymorphisms and their clinical relevance in a Chinese Han population. Crit Care Med. 2008;36:2274-80 pubmed publisher
    Several polymorphisms in the CD14 promoter have been reported to be associated with various inflammatory diseases. However, conflicting results have been shown in association studies in different populations...
  5. Nakada T, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M, et al. Influence of toll-like receptor 4, CD14, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients. J Surg Res. 2005;129:322-8 pubmed
    ..This study investigated toll-like receptor (TLR) 4, CD14, tumor necrosis factor (TNF)-alpha and -beta, and interleukin (IL)-10 gene polymorphisms in 197 Japanese critically ..
  6. Azzam N, Nounou H, Alharbi O, Aljebreen A, Shalaby M. CARD15/NOD2, CD14 and toll-like 4 receptor gene polymorphisms in Saudi patients with Crohn's Disease. Int J Mol Sci. 2012;13:4268-80 pubmed publisher
    ..Polymorphisms in the CARD15/NOD2 gene, in addition to functional variants of the toll-like receptor-4 (TLR4) and CD14 genes, have been associated with the development of Crohn's disease...
  7. Baier R, Loggins J, Yanamandra K. IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants. BMC Med. 2006;4:10 pubmed
    ..birth weight (VLBW) infants (<1500 grams at birth) who were genotyped for the IL-6 -174 G/C, IL-10 -1082 G/A and CD14 -260 C/T single nucleotide polymorphisms (SNPs)...
  8. Zeng H, Chen X, Luo X. The association with the -159C/T polymorphism in the promoter region of the CD14 gene and juvenile idiopathic arthritis in a Chinese Han population. J Rheumatol. 2009;36:2025-8 pubmed publisher
    ..We investigated the association of a C-to-T transition in the promoter region of the CD14 gene on chromosome 5q31.1 and JIA in a Chinese Han population...
  9. Tan C, Chen Y, Wu L, Liu C, Chang W, Wang J. Association of CD14 promoter polymorphisms and soluble CD14 levels in mite allergen sensitization of children in Taiwan. J Hum Genet. 2006;51:59-67 pubmed
    b>CD14 is responsible for environmental lipopolysaccharide recognition and is a positional candidate gene for allergy...
  10. Kang Y, Lee H, Kim Y, Han S, Shim Y, Yim J. Association between the -159C/T CD14 gene polymorphism and tuberculosis in a Korean population. FEMS Immunol Med Microbiol. 2009;57:229-35 pubmed publisher
    The aim of the present study was to confirm the association between the CD14-159C/T polymorphism and tuberculosis in the Korean population and to elucidate the functional basis for this putative association...
  11. Dong N, Yao Y, Huang X, He L, Yu Y, Sheng Z. [Influence of CD14 gene polymorphism on the expression of high mobility group box-1 protein in patients with severe burn]. Zhonghua Shao Shang Za Zhi. 2010;26:109-12 pubmed
    To investigate the influence of the lipopolysaccharide receptor CD14-159C/T gene polymorphism on the synthesis and release of high mobility group box-1 protein (HMGB1), and its relation to sepsis in patients with severe burn...
  12. Surbatovic M, Grujic K, Cikota B, Jevtic M, Filipovic N, Romic P, et al. Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients. J Crit Care. 2010;25:542.e1-8 pubmed publisher
    ..the study was to determine whether distributions of tumor necrosis factor (TNF)-?(308), interleukin (IL)-10(1082), CD14(159), and IL-1ra gene intron 2 genotypes in critically ill patients are associated with outcome, underlying cause ..
  13. Vainas T, Stassen F, Bruggeman C, Welten R, van den Akker L, Kitslaar P, et al. Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease. J Vasc Surg. 2006;44:326-32 pubmed
    Genes involved in the regulation of immune responses, such as Toll-like receptor 4 (TLR4) and CD14, show genetic variations with potential functional implications...
  14. Raunio T, Knuuttila M, Karttunen R, Vainio O, Tervonen T. Serum sCD14, polymorphism of CD14(-260) and periodontal infection. Oral Dis. 2009;15:484-9 pubmed publisher
    b>CD14 is a co-receptor involved in the recognition of Gram-negative and positive bacteria...
  15. Xue Y, Zhao Z, Chen F, Zhang L, Li G, Ma K, et al. Polymorphisms in the promoter of the CD14 gene and their associations with susceptibility to pulmonary tuberculosis. Tissue Antigens. 2012;80:437-43 pubmed publisher
    Although the role of CD14 in recognizing Mycobacterium tuberculosis is well-understood, the possible role of polymorphisms in susceptibility to develop tuberculosis remains unclear...
  16. Simpson A, John S, Jury F, Niven R, Woodcock A, Ollier W, et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am J Respir Crit Care Med. 2006;174:386-92 pubmed
    ..To determine the relationship between a promoter polymorphism in the CD14 gene (CD14/-159 C to T) and endotoxin exposure in relation to the development of allergic sensitization, eczema, ..
  17. Regueiro V, Campos M, Morey P, Sauleda J, Agusti A, Garmendia J, et al. Lipopolysaccharide-binding protein and CD14 are increased in the bronchoalveolar lavage fluid of smokers. Eur Respir J. 2009;33:273-81 pubmed publisher
    Lipopolysaccharide-binding protein (LBP) and CD14 contribute to the recognition of pathogens by cells, which triggers the activation of defence responses...
  18. Andrie E, Michos A, Kalampoki V, Pourtsidis A, Moschovi M, Polychronopoulou S, et al. Genetic variants in immunoregulatory genes and risk for childhood lymphomas. Eur J Haematol. 2009;83:334-42 pubmed publisher
    ..nine genes with important role in immunoregulatory pathways (IL4, IL4R, IL6, IL10, IL12, IL18, TNFalpha, IFNgamma, CD14)...
  19. Zhang A, Yue C, Gu W, Du J, Wang H, Jiang J. Association between CD14 promoter -159C/T polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis. PLoS ONE. 2013;8:e71237 pubmed publisher
    Recent studies on the association between CD14-159C/T polymorphism and sepsis showed inconclusive results...
  20. Wu M, Cheng T, Shun C, Lin M, Chen L, Lin J. Functional polymorphisms of CD14 and toll-like receptor 4 in Taiwanese Chinese with Helicobacter pylori-related gastric malignancies. Hepatogastroenterology. 2006;53:807-10 pubmed
    ..pylori, which activate monocytes to express cytokine expression and growth factors via CD14 and toll-like receptor 4 (TLR4). Whether functional polymorphisms of TLR 4 and CD14 account for H...
  21. Barber R, Chang L, Lemaire S, Burris A, Purdue G, Hunt J, et al. Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury. J Burn Care Res. 2008;29:168-75 pubmed publisher
    ..data were collected prospectively and candidate polymorphisms in PAI-1 (-688), toll-like receptor 4 (+896), CD14 (-159), tumor necrosis factor-alpha (-308), and interleukin-6 (-174) were genotyped...
  22. Wang Z, Hu J, Fan R, Zhou J, Zhong J. Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis. PLoS ONE. 2012;7:e45144 pubmed publisher
    The gene encoding CD14 has been proposed as an IBD-susceptibility gene with its polymorphism C-260T being widely evaluated, yet with conflicting results...
  23. Jessen K, Lindboe S, Petersen A, Eugen Olsen J, Benfield T. Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. BMC Infect Dis. 2007;7:108 pubmed
    ..interleukin-1 beta (IL-1 beta), plasminogen activator-1 (PAI-1), urokinase plasminogen activator (uPA), CD14 and toll-like receptor 4 (TLR4) was done...
  24. Yu X, Zhang C, Sun A, Jiang L, Zheng J, You Y, et al. Genetic variations in CD14 promoter and acute lymphoblastic leukemia susceptibility in a Chinese population. DNA Cell Biol. 2011;30:777-82 pubmed publisher
    Recent findings suggest that CD14 may play a role in tumor development. Previous case-control studies have revealed that CD14 -260C/T and -651?C/T polymorphisms contribute to the risk of human diseases...
  25. Raj D, Carrero J, Shah V, Qureshi A, Barany P, Heimburger O, et al. Soluble CD14 levels, interleukin 6, and mortality among prevalent hemodialysis patients. Am J Kidney Dis. 2009;54:1072-80 pubmed publisher
    b>CD14 is a pattern-recognition receptor that has a central immunomodulatory role in proinflammatory signaling in response to a variety of ligands, including endotoxin. CD14 protein is present in 2 forms: soluble (sCD14) and membrane bound...
  26. Yin G, Jeon H, Lee S, Lee H, Cho J, Suk K. Role of soluble CD14 in cerebrospinal fluid as a regulator of glial functions. J Neurosci Res. 2009;87:2578-90 pubmed publisher
    ..analysis, and Western blot validation, it was found that the level of soluble form of monocyte differentiation antigen CD14 precursor was elevated in CSF from AD or PD patients compared with normal subjects...
  27. de Aguiar B, Girardi I, Paskulin D, de Franca E, Dornelles C, Dias F, et al. CD14 expression in the first 24h of sepsis: effect of -260C>T CD14 SNP. Immunol Invest. 2008;37:752-69 pubmed publisher
    Sepsis is defined as systemic inflammation caused by infection. The membrane bound CD14 (mCD14) or the soluble form (sCD14) play a crucial role facing Gram-negative and Gram-positive sepsis since they are pattern recognition receptors of ..
  28. Chan I, Tang N, Leung T, Huang W, Lam Y, Li C, et al. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. Allergy. 2008;63:1031-9 pubmed publisher
  29. Lin J, Yao Y, Yu Y, Chai J, Huang Z, Dong N, et al. Effects of CD14-159 C/T polymorphism on CD14 expression and the balance between proinflammatory and anti-inflammatory cytokines in whole blood culture. Shock. 2007;28:148-53 pubmed
    b>CD14 is an important receptor of innate immunity. When CD14 is anchored by ligands to LPS, peptidoglycans, or lipoteichoic acid, it can result in either proinflammatory or anti-inflammatory responses...
  30. Shih H, Lin T, Chuang J, Eng H, Juo S, Huang F, et al. Promoter polymorphism of the CD14 endotoxin receptor gene is associated with biliary atresia and idiopathic neonatal cholestasis. Pediatrics. 2005;116:437-41 pubmed
    To investigate whether single-nucleotide polymorphisms in the promoter regions of endotoxin-responsive genes CD14 and tumor necrosis factor-alpha (TNF-alpha) are associated with biliary atresia (BA) and idiopathic neonatal cholestasis (..
  31. Zhao D, Sun T, Zhang X, Guo Y, Yu D, Yang M, et al. Role of CD14 promoter polymorphisms in Helicobacter pylori infection--related gastric carcinoma. Clin Cancer Res. 2007;13:2362-8 pubmed
    Genetic variation in CD14 may affect CD14 expression and susceptibility to Helicobacter pylori infection-related cancers...
  32. Wu X, Li Y, Chen Q, Chen F, Cai P, Wang L, et al. Association and gene-gene interactions of eight common single-nucleotide polymorphisms with pediatric asthma in middle china. J Asthma. 2010;47:238-44 pubmed publisher
    ..with a best six-locus model among IL-4 -C33T, IL-13 R130Q, IL-4Ralpha I75V, IL-4Ralpha Q576R, STAT6 C2892T, and CD14 -C159T on the risk of asthma (OR = 4.43, 95% CI 1.30-15.04, p < .001, by 1000-fold permutation test)...
  33. Abu Maziad A, Schaa K, Bell E, Dagle J, Cooper M, Marazita M, et al. Role of polymorphic variants as genetic modulators of infection in neonatal sepsis. Pediatr Res. 2010;68:323-9 pubmed publisher
    ..IL1B, and TNF), cytokine receptors (IL1RN), toll-like receptors (TLR2, TLR4, and TLR5), and cell surface receptors (CD14) were genotyped. Subjects were stratified into three groups (sepsis, suspected sepsis, and control)...
  34. Okada R, Suzuki K, Ito Y, Nishio K, Ishida Y, Kawai S, et al. Association between decreased kidney function and endotoxin receptor CD14 C-159T polymorphism among Japanese health check-up examinees. Ren Fail. 2007;29:967-72 pubmed
    A recently identified promoter polymorphism of the endotoxin receptor (CD14 C-159T) was shown to be associated with atherosclerotic diseases such as myocardial infarction...
  35. Zhang H, Zhong B, Zhu W, Xie S, Qiu L, Zhu L, et al. CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis. Genet Med. 2009;11:403-8 pubmed publisher
    The CD14 gene C-260T polymorphism has been reported to be associated with ischemic heart disease, but results were conflicting...
  36. Lakatos P, Kiss L, Palatka K, Altorjay I, Antal Szalmas P, Palyu E, et al. Serum lipopolysaccharide-binding protein and soluble CD14 are markers of disease activity in patients with Crohn's disease. Inflamm Bowel Dis. 2011;17:767-77 pubmed publisher
    ..study we investigated the association between serum level of lipopolysaccharide-binding protein (LBP), soluble CD14 (sCD14), and clinical disease activity, high-sensitivity C-reactive protein (hs-CRP), antimicrobial serology ..
  37. Zhao L, Bracken M. Association of CD14 -260 (-159) C>T and asthma: a systematic review and meta-analysis. BMC Med Genet. 2011;12:93 pubmed publisher
    ..Asthma is a phenotypically diverse disease with genetic susceptibility. A single nucleotide polymorphism (SNP) in the CD14 gene at position -260 (also known as -159) C>T has been inconsistently associated with asthma...
  38. Klausz G, Molnar T, Nagy F, Gyulai Z, Boda K, Lonovics J, et al. Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn's disease. Scand J Gastroenterol. 2005;40:1197-204 pubmed
    ..Several previous studies have investigated the roles of CD14, heat-shock protein (Hsp)70 and IL-10 gene polymorphisms in the development of the disease...
  39. Martinez F. CD14, endotoxin, and asthma risk: actions and interactions. Proc Am Thorac Soc. 2007;4:221-5 pubmed
    A functional single nucleotide polymorphism in the 5 genomic region of CD14 (CD14/-159) is one of the most widely tested genetic variations in relation to asthma and associated traits...
  40. Zeng T, Zhang C, Han X, Zhao S, Xie K. Association between CD14-159C>T polymorphisms and the risk for alcoholic liver disease: a meta-analysis. Eur J Gastroenterol Hepatol. 2013;25:1183-9 pubmed publisher
    The association between CD14-159C>T polymorphisms and alcoholic liver disease (ALD) risk has been investigated in many studies, but the results were inconsistent...
  41. Hong S, Kim H, Kang M, Lee S, Kim J, Kim B, et al. TNF-alpha (-308 G/A) and CD14 (-159T/C) polymorphisms in the bronchial responsiveness of Korean children with asthma. J Allergy Clin Immunol. 2007;119:398-404 pubmed
    ..might be linked to asthma or bronchial hyperresponsiveness (BHR), and TNF-alpha production might be modulated by CD14(+) cells...
  42. Companioni O, Bonet C, Munoz X, Weiderpass E, Panico S, Tumino R, et al. Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European Prospective Investigation into Cancer-Eurgast cohort. Int J Cancer. 2014;134:92-101 pubmed publisher
    ..Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro-inflammatory cytokines to elicit an ..
  43. Rogacev K, Cremers B, Zawada A, Seiler S, Binder N, Ege P, et al. CD14++CD16+ monocytes independently predict cardiovascular events: a cohort study of 951 patients referred for elective coronary angiography. J Am Coll Cardiol. 2012;60:1512-20 pubmed publisher
    ..Three distinct human monocyte subsets exist: classical CD14++CD16-, intermediate CD14++CD16+, and nonclassical CD14+CD16++ monocytes...
  44. Poitou C, Dalmas E, Renovato M, Benhamo V, Hajduch F, Abdennour M, et al. CD14dimCD16+ and CD14+CD16+ monocytes in obesity and during weight loss: relationships with fat mass and subclinical atherosclerosis. Arterioscler Thromb Vasc Biol. 2011;31:2322-30 pubmed publisher
    Studies suggest the implication of CD16(+) subpopulations (CD14(+)CD16(+), CD14(dim)CD16(+)) in inflammatory diseases...
  45. Mohamed J, DuPont H, Flores J, Palur H, Nair P, Jiang Z, et al. Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico. Clin Infect Dis. 2011;52:1332-41 pubmed publisher
    Under normal conditions, the expression of CD14, which is the principal receptor for bacterial lipopolysaccharide, is down-regulated in the intestinal mucosa but increases in response to inflammatory stimuli...
  46. LeVan T, Michel O, Dentener M, Thorn J, Vertongen F, Beijer L, et al. Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation. J Allergy Clin Immunol. 2008;121:434-440.e1 pubmed
    A prerequisite for activation of the innate immune response by endotoxin is its binding to CD14. The aim of this study was to evaluate the role of CD14 polymorphisms, atopy, and inhaled endotoxin in modulating serum CD14 levels...
  47. Alavi Naini R, Salimi S, Sharifi Mood B, Davoodikia A, Moody B, Naghavi A. Association between the CD14 gene C-159T polymorphism and serum soluble CD14 with pulmonary tuberculosis. Int J Tuberc Lung Dis. 2012;16:1383-7 pubmed publisher
    Functional C-159T polymorphism in the promoter region of the CD14 lipopolysaccharide receptor has been reported to be associated with the development of tuberculosis (TB)...
  48. Sackesen C, Karaaslan C, Keskin O, Tokol N, Tahan F, Civelek E, et al. The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma. Allergy. 2005;60:1485-92 pubmed
    ..To investigate the effects of the genetic variants of CD14 and TLR4 genes on asthma phenotypes in a large number of asthmatic children...
  49. Castano Rodriguez N, Kaakoush N, Goh K, Fock K, Mitchell H. The role of TLR2, TLR4 and CD14 genetic polymorphisms in gastric carcinogenesis: a case-control study and meta-analysis. PLoS ONE. 2013;8:e60327 pubmed publisher
    ..aim of this study was to estimate for the first time the pooled effect size of polymorphisms in TLR2, TLR4 and CD14 on GC development through a meta-analysis...
  50. Han D, She W, Zhang L. Association of the CD14 gene polymorphism C-159T with allergic rhinitis. Am J Rhinol Allergy. 2010;24:e1-3 pubmed publisher
    Altered expression of the cluster differentiation antigen, CD14, may affect the proportion of T-helper type 1 (Th1) to Th2 cells, thereby influencing the immunoglobulin E (IgE) response and associated inflammatory phenotype in allergic ..
  51. Shin H, Park K, Park B, Cheong H, Cho Y, Lee H, et al. Common promoter polymorphism in monocyte differentiation antigen CD14 is associated with serum triglyceride levels and body mass index in non-diabetic individuals. Diabet Med. 2006;23:72-6 pubmed
    ..The monocyte differentiation antigen CD14 gene (CD14) acts as the receptor for lipopolysaccharide (LPS) and augments monocyte/macrophage ..
  52. D Avila L, Albarus M, Franco C, Aguiar B, Oliveira J, Dias F, et al. Effect of CD14 -260C>T polymorphism on the mortality of critically ill patients. Immunol Cell Biol. 2006;84:342-8 pubmed
    The CD14 receptor seems to be an important part of the innate immune system...
  53. Kowal K, Bodzenta Lukaszyk A, Pampuch A, Szmitkowski M, Zukowski S, Donati M, et al. Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients. J Investig Allergol Clin Immunol. 2008;18:284-92 pubmed
    ..On the other hand, LPS induces PAI-1 secretion. Activation of individual cells by LPS is facilitated by CD14. The single nucleotide polymorphisms -675 4G/5G in SERPINE1 and C-159T in CD14 are major determinants of PAI-1 and ..
  54. Guo Q, Zhu J, Xia B. Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients. J Gastroenterol Hepatol. 2006;21:92-7 pubmed
    Toll-like receptor 4 and CD14 are components of the lipopolysaccharide receptor complex. Our study aimed to investigate an association between TLR4 Asp299Gly and CD14-260 polymorphisms in Chinese patients with colorectal cancer...
  55. Lin J, Yao Y, Dong N, Chai J, Yu Y, Hou X, et al. Influence of CD14 polymorphism on CD14 expression in patients with extensive burns. Burns. 2009;35:365-71 pubmed publisher
    We sought to investigate the association of CD14 genotype with the risk of mortality after burn, and we also attempted to evaluate whether CD14-159 C/T polymorphism affects the kinetics and extent of CD14 expression as well as its release,..
  56. Baumgart D, Buning C, Geerdts L, Schmidt H, Genschel J, Fiedler T, et al. The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease. Digestion. 2007;76:196-202 pubmed publisher
    ..n = 118) and healthy controls (n = 605; German n = 403, Hungarian n = 202) were genotyped for the presence of the CD14 c.1-260C>T promoter variant and the TLR4 c.896A>G (p...
  57. Virta M, Pessi T, Helminen M, Seiskari T, Kondrashova A, Knip M, et al. Interaction between CD14-159C>T polymorphism and Helicobacter pylori is associated with serum total immunoglobulin E. Clin Exp Allergy. 2008;38:1929-34 pubmed publisher
    ..Association and linkage studies have suggested a role of CD14-159C>T polymorphism in the regulation of serum total IgE, but the results have been contradictory...
  58. Rosas Taraco A, Revol A, Salinas Carmona M, Rendon A, Caballero Olin G, Arce Mendoza A. CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. J Infect Dis. 2007;196:1698-706 pubmed
    Neither the expression of CD14 and Toll-like receptor 4 (TLR4) on monocytes' surface nor the mutations CD14 -159TT and TLR4 Asp299Gly have yet been evaluated as risk factors for development of pulmonary tuberculosis (TB) in the Mexican ..
  59. Nishimura F, Shibasaki M, Ichikawa K, Arinami T, Noguchi E. Failure to find an association between CD14-159C/T polymorphism and asthma: a family-based association test and meta-analysis. Allergol Int. 2006;55:55-8 pubmed
    b>CD14 is an essential component of the receptor for lipopolysaccharide (LPS). LPS stimulates T-helper type 1 (Th1) cytokine expression, potentially suppressing Th2 immune responses involved in IgE-mediated allergic diseases...
  60. Barber R, Aragaki C, Chang L, Purdue G, Hunt J, Arnoldo B, et al. CD14-159 C allele is associated with increased risk of mortality after burn injury. Shock. 2007;27:232-7 pubmed
    ..genotype at five candidate loci (interleukin [IL]-1beta, IL-6, tumor necrosis factor-alpha, toll-like receptor 4, CD14) on mortality risk after burn injury...
  61. Guo Q, Xia B, Jiang Y, Morre S, Cheng L, Li J, et al. Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients. Postgrad Med J. 2005;81:526-9 pubmed
    Toll-like receptor 4 and CD14 are the components of the lipopolysaccharide receptor complex...
  62. Wang J, Liou Y, Wu Y, Hsiao Y, Wu L. An association study of 13 SNPs from seven candidate genes with pediatric asthma and a preliminary study for genetic testing by multiple variants in Taiwanese population. J Clin Immunol. 2009;29:205-9 pubmed publisher
    ..b>CD14-159 C/T and MS4A2 Glu237Gly were identified to have difference in genotype/allele frequencies between the control ..
  63. Pu H, Yin J, Wu Y, Zhang D, Wang Y, Zhou R, et al. The association between CD14 gene C-260T polymorphism and coronary heart disease risk: a meta-analysis. Mol Biol Rep. 2013;40:4001-8 pubmed publisher
    b>Monocyte differentiation antigen CD14 is considered an important cell-activating mediator of inflammatory responses that may result in atherosclerosis, coronary heart disease (CHD), thrombus formation, and myocardial infarction (MI)...
  64. Smit L, Siroux V, Bouzigon E, Oryszczyn M, Lathrop M, Demenais F, et al. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med. 2009;179:363-8 pubmed publisher
    ..To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with asthma in adults, and whether these SNPs ..
  65. Türe Ozdemir F, Gazouli M, Tzivras M, Panagos C, Bovaretos N, Petraki K, et al. Association of polymorphisms of NOD2, TLR4 and CD14 genes with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma. Anticancer Res. 2008;28:3697-700 pubmed
    ..The aim of this study was to evaluate the relationship between NOD2, TLR4 and CD14 genetic polymorphisms and the development of gastric MALT-lymphoma...
  66. Leung E, Hong J, Fraser A, Merriman T, Vishnu P, Abbott W, et al. Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patients. Immunol Cell Biol. 2005;83:498-503 pubmed
    ..Other potential susceptibility genes such as CD14 may compound the risk of developing CD...
  67. Petermann I, Huebner C, Browning B, Gearry R, Barclay M, Kennedy M, et al. Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort. Hum Immunol. 2009;70:440-6 pubmed publisher
    ..We now consider the effects of SNPs in CD14, TLR9, and BPI, analyzed individually, in association with one another, and with SNPs in CARD15 or TLR4 in this ..
  68. Biebl A, Muendlein A, Kazakbaeva Z, Heuberger S, Sonderegger G, Drexel H, et al. CD14 C-159T and toll-like receptor 4 Asp299Gly polymorphisms in surviving meningococcal disease patients. PLoS ONE. 2009;4:e7374 pubmed publisher
    ..The functional single nucleotide polymorphisms (SNPs) CD14 C-159T and toll-like receptor 4 (TLR4) Asp299Gly have been associated with the risk of gram-negative infections...
  69. Mason T, Ricks Santi L, Chen W, Apprey V, Joykutty J, Ahaghotu C, et al. Association of CD14 variant with prostate cancer in African American men. Prostate. 2010;70:262-9 pubmed publisher
    ..is an etiological factor in prostate cancer, we hypothesize that sequence variants in the promoter region of the CD14 gene that regulate inflammation may modify individual susceptibility to this disease...
  70. Huebinger R, Garner H, Barber R. Pathway genetic load allows simultaneous evaluation of multiple genetic associations. Burns. 2010;36:787-92 pubmed publisher
    ..011) and death (aOR=1.75; 95%CI=1.11-2.76; p=0.017). Relative size and variability of aORs indicate greater power to detect genetic associations with PGL compared to the analysis of loci individually by multivariate logistic regression. ..
  71. Liang X, Cheung W, Heng C, Liu J, Li C, Lim B, et al. CD14 promoter polymorphisms have no functional significance and are not associated with atopic phenotypes. Pharmacogenet Genomics. 2006;16:229-36 pubmed
    A polymorphism at CD14/-159 has been reported to be associated with atopic phenotypes in several studies. However, conflicting results from association studies in different populations have been reported...
  72. Landi S, Gemignani F, Bottari F, Gioia Patricola L, Guino E, Cambray M, et al. Polymorphisms within inflammatory genes and colorectal cancer. J Negat Results Biomed. 2006;5:15 pubmed
    ..ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>..
  73. Jersmann H. Time to abandon dogma: CD14 is expressed by non-myeloid lineage cells. Immunol Cell Biol. 2005;83:462-7 pubmed
    b>CD14 is a pattern recognition receptor; its important role in innate immunity is reviewed here...
  74. Kang H, Choi Y, Chae S, Woo J, Hwang S, Lee H. Polymorphism of the CD14 gene in perennial allergic rhinitis. Int J Pediatr Otorhinolaryngol. 2006;70:2081-5 pubmed
    Allergic diseases have strong genetic backgrounds. Recently, a C-T polymorphism in the promoter region of CD14 has been associated with phenotypes of atopy in some populations...
  75. Zhao M, Xue Y, Zhao Z, Li F, Fan D, Wei L, et al. Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population. Genet Mol Res. 2012;11:3425-31 pubmed publisher
    Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear...
  76. Chao Y, Chu H, Chang W, Huang H, Hsieh T. CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis. World J Gastroenterol. 2005;11:6043-8 pubmed
    To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic ..
  77. Hold G, Rabkin C, Gammon M, Berry S, Smith M, Lissowska J, et al. CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations. Eur J Cancer Prev. 2009;18:117-9 pubmed publisher
    ..The CD14-159C/T and the TLR9-1237T/C promoter polymorphisms have previously been shown to be associated with various ..
  78. Hartel C, Rupp J, Hoegemann A, Bohler A, Spiegler J, von Otte S, et al. 159C>T CD14 genotype--functional effects on innate immune responses in term neonates. Hum Immunol. 2008;69:338-43 pubmed publisher
    ..We studied the functional relevance of the 159C>T CD14 single nucleotide polymorphism in cord blood samples of n=135 healthy term neonates by investigation of sCD14, ..
  79. Marcos V, Latzin P, Hector A, Sonanini S, Hoffmann F, Lacher M, et al. Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases. Respir Res. 2010;11:32 pubmed publisher
    ..Bacterial lipopolysaccharide (LPS) is recognized via Toll-like receptors and CD14. CD14 exists as a soluble (sCD14) and membrane-associated (mCD14) protein, present on the surface of leukocytes...
  80. Shalhub S, Pham T, Gibran N, O Keefe G. Tumor necrosis factor gene variation and the risk of mortality after burn injury: a cohort study. J Burn Care Res. 2009;30:105-11 pubmed publisher
    ..G-308A, Interleukin-6 (IL-6) G-174C, interleukin-1beta (IL-1beta) T-31C, and cluster of differentiation marker 14 (CD14) C-159T. We compared SNP genotypes between survivors and nonsurvivors by chi analysis and logistic regression...
  81. Kuo Chou T, Li Y, Lue K, Liao C, Lin C, Tzeng P, et al. Genetic polymorphism of manganese superoxide dismutase is associated with childhood asthma. J Asthma. 2010;47:532-8 pubmed publisher
    ..b>CD14 is a receptor for various bacterial products, such as lipopolysaccharides (LPS), and is also a mediator of ..
  82. Wang F, Tahara T, Arisawa T, Shibata T, Nakamura M, Fujita H, et al. Genetic polymorphisms of CD14 and Toll-like receptor-2 (TLR2) in patients with ulcerative colitis. J Gastroenterol Hepatol. 2007;22:925-9 pubmed
    ..The aim of this study was to investigate the association between CD14 and Toll-like receptor-2 (TLR2) genetic polymorphisms and chronic UC in Japanese patients...
  83. Tahara T, Arisawa T, Shibata T, Hirata I, Nakano H. Association of polymorphism of TLR4 and CD14 genes with gastroduodenal diseases in Japan. Inflammopharmacology. 2007;15:124-8 pubmed
    ..Toll like receptor 4(TLR4) and CD14-mediated recognition of lipo-polysaccharide (LPS) is required for efficient recognition of Gram-negative bacterial ..
  84. Kim E, Chung W, Lee K, Paik C, Jung S, Lee B, et al. Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population. J Korean Med Sci. 2012;27:72-7 pubmed publisher
    ..However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of IBD has not been fully elucidated...