CD133

Summary

Gene Symbol: CD133
Description: prominin 1
Alias: AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4, prominin-1, antigen AC133, hProminin, hematopoietic stem cell antigen, prominin-like protein 1
Species: human
Products:     CD133

Top Publications

  1. Florek M, Haase M, Marzesco A, Freund D, Ehninger G, Huttner W, et al. Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer. Cell Tissue Res. 2005;319:15-26 pubmed
    Human prominin-1/CD133 has been reported to be expressed in neural and hematopoietic stem/progenitor cells and in embryonic, but not adult, epithelia...
  2. Mehra N, Penning M, Maas J, Beerepoot L, van Daal N, van Gils C, et al. Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases. Clin Cancer Res. 2006;12:4859-66 pubmed
    We examined whether RNA expression of CD133, a surface molecule expressed on progenitors from hematopoietic and endothelial lineages, and CD146, a pan-endothelial marker, are increased in the blood of cancer patients and whether these ..
  3. Smith L, Nesterova A, Ryan M, Duniho S, Jonas M, Anderson M, et al. CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers. Br J Cancer. 2008;99:100-9 pubmed publisher
    ..A murine anti-human CD133 antibody (AC133) conjugated to a potent cytotoxic drug, monomethyl auristatin F (MMAF), effectively inhibited the growth of Hep3B ..
  4. Horst D, Kriegl L, Engel J, Kirchner T, Jung A. CD133 expression is an independent prognostic marker for low survival in colorectal cancer. Br J Cancer. 2008;99:1285-9 pubmed publisher
    Colon cancer cells have previously been demonstrated to contain a subpopulation of CD133+ tumour cells that have the ability to initiate tumour growth and are thus referred to as colon cancer-initiating cells or colon cancer stem cells (..
  5. Corbo C, Orru S, Gemei M, Noto R, Mirabelli P, Imperlini E, et al. Protein cross-talk in CD133+ colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenicity. Proteomics. 2012;12:2045-59 pubmed publisher
    ..Putative CSCs were separated from non-CSCs by flow cytometry using CD133 as stemness marker...
  6. Zhang H, Wei Y, Wang M, Wu C, Yang Y, Chen J, et al. [Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:696-9 pubmed
    To investigate the expression of tumor stem cell marker CD133 and endothelin-converting enzymes (ECE) in non-small cell lung carcinoma (NSCLC) and their association with NSCLC lymphoid metastasis...
  7. Sartelet H, Imbriglio T, Nyalendo C, Haddad E, Annabi B, Duval M, et al. CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway. Histopathology. 2012;60:1144-55 pubmed publisher
    Neuroblastoma is a frequent childhood cancer with a heterogeneous prognosis. CD133 expression is an independent prognostic marker for a low survival rate in several cancers...
  8. Fukamachi H, Shimada S, Ito K, Ito Y, Yuasa Y. CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Sci. 2011;102:1313-21 pubmed publisher
    b>CD133 is a universal marker of tissue stem/progenitor cells as well as cancer stem cells, but its physiological significance remains to be elucidated...
  9. Mak A, Nixon A, Kittanakom S, Stewart J, Chen G, Curak J, et al. Regulation of CD133 by HDAC6 promotes ?-catenin signaling to suppress cancer cell differentiation. Cell Rep. 2012;2:951-63 pubmed publisher
    The pentaspan membrane glycoprotein CD133 marks lineage-specific cancer progenitor cells and is associated with poor prognosis in a number of tumor types...

More Information

Publications114 found, 100 shown here

  1. Kojima M, Ishii G, Atsumi N, Fujii S, Saito N, Ochiai A. Immunohistochemical detection of CD133 expression in colorectal cancer: a clinicopathological study. Cancer Sci. 2008;99:1578-83 pubmed publisher
    b>CD133 has been reported to be a cancer-initiating cell marker in colorectal carcinoma...
  2. Curley M, Therrien V, Cummings C, Sergent P, Koulouris C, Friel A, et al. CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells. 2009;27:2875-83 pubmed publisher
    ..of human ovarian tumors for expression of candidate CSC surface markers indicated consistent expression of CD133. To determine whether CD133 expression could define a tumor-initiating cell population in primary human ovarian ..
  3. Rappa G, Fodstad O, Lorico A. The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells. 2008;26:3008-17 pubmed publisher
    b>CD133 (Prominin-1) is considered the most important cancer stem cell (CSC)-associated marker identified so far, with increased expression in the CSC fraction of a large variety of human malignancies, including melanoma...
  4. Li H, Zhao P, Lu Y, Lu Y. Correlation of aberrant expression of CD133 with FHIT and malignant phenotype of colorectal adenocarcinoma. Int J Colorectal Dis. 2012;27:1015-20 pubmed
    The relationship between the expression of CD133 and fragile histidine triad (FHIT) or prognosis in Chinese colorectal adenocarcinoma is unknown and needs to be explored...
  5. Karbanova J, Missol Kolka E, Fonseca A, Lorra C, Janich P, Hollerová H, et al. The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia. J Histochem Cytochem. 2008;56:977-93 pubmed publisher
    Human prominin-1 (CD133) is expressed by various stem and progenitor cells originating from diverse sources...
  6. Ong C, Kim L, Kong H, Low L, Iacopetta B, Soong R, et al. CD133 expression predicts for non-response to chemotherapy in colorectal cancer. Mod Pathol. 2010;23:450-7 pubmed publisher
    ..In this study, immunohistochemistry for three candidate cancer stem cell markers (CD133, Oct-4 and Sox-2) and for six other postulated prognostic markers (CK7, CK20, Cox-2, Ki-67, p27 and p53) were ..
  7. Hang D, Dong H, Ning T, Dong B, Hou D, Xu W. Prognostic value of the stem cell markers CD133 and ABCG2 expression in esophageal squamous cell carcinoma. Dis Esophagus. 2012;25:638-44 pubmed publisher
    ..light of increasing evidence supporting cancer stem cells (CSCs) theory, the expression of two stem cell markers, CD133 and adenosine triphosphate-binding cassette superfamily G member 2 (ABCG2), in esophageal squamous cell carcinoma (..
  8. Kemper K, Sprick M, de Bree M, Scopelliti A, Vermeulen L, Hoek M, et al. The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res. 2010;70:719-29 pubmed publisher
    Colon cancer stem cells (CSC) can be identified with AC133, an antibody that detects an epitope on CD133...
  9. Giebel B, Corbeil D, Beckmann J, Höhn J, Freund D, Giesen K, et al. Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells. Blood. 2004;104:2332-8 pubmed
    ..leukocytes; and (3) redistribute several lipid raft markers including cholesterol-binding protein prominin-1 (CD133) in specialized plasma membrane domains...
  10. O Brien C, Pollett A, Gallinger S, Dick J. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007;445:106-10 pubmed
    ..Purification experiments established that all CC-ICs were CD133+; the CD133- cells that comprised the majority of the tumour were unable to initiate tumour growth...
  11. Platet N, Liu S, Atifi M, Oliver L, Vallette F, Berger F, et al. Influence of oxygen tension on CD133 phenotype in human glioma cell cultures. Cancer Lett. 2007;258:286-90 pubmed
    ..We demonstrate, using low-passaged human tumor cell cultures established from glioma, that a reduction in the oxygen level in these cell cultures dramatically increases the percentage of CD133 expressing cells.
  12. Bourseau Guilmain E, Griveau A, Benoit J, Garcion E. The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells. PLoS ONE. 2011;6:e25515 pubmed publisher
    As the pentaspan stem cell marker CD133 was shown to bind cholesterol and to localize in plasma membrane protrusions, we investigated a possible function for CD133 in endocytosis...
  13. Feng H, Liu Y, Yang L, Bian X, Yang Z, Gu B, et al. Expression of CD133 correlates with differentiation of human colon cancer cells. Cancer Biol Ther. 2010;9:216-23 pubmed
    b>CD133 has been identified as a cancer stem cell marker in colon and several other cancers, but its function is still unknown...
  14. Li F, Zeng H, Ying K. The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage I non-small cell lung carcinomas. Med Oncol. 2011;28:1458-62 pubmed publisher
    The aim of the study was to investigate the expression of two cancer stem cell markers CD133 and ATP-binding cassette superfamily G member 2 (ABCG2) in non-small cell lung carcinomas (NSCLC) and evaluate their prognostic values for ..
  15. Arrigoni F, Matarin M, Thompson P, Michaelides M, McClements M, Redmond E, et al. Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy. Eur J Hum Genet. 2011;19:131-7 pubmed publisher
    Mutations in prominin 1 (PROM1) have been shown to result in retinitis pigmentosa, macular degeneration and cone-rod dystrophy...
  16. Wang T, Ong C, Shi J, Srivastava S, Yan B, Cheng C, et al. Sequential expression of putative stem cell markers in gastric carcinogenesis. Br J Cancer. 2011;105:658-65 pubmed publisher
    ..Several biomarkers including CD44, Musashi-1 and CD133 have been reported as putative stem cell (PSC) markers...
  17. Griguer C, Oliva C, Gobin E, Marcorelles P, Benos D, Lancaster J, et al. CD133 is a marker of bioenergetic stress in human glioma. PLoS ONE. 2008;3:e3655 pubmed publisher
    ..Recently, many studies have focused on isolation of brain cancer stem cells using CD133 expression...
  18. Horst D, Kriegl L, Engel J, Kirchner T, Jung A. Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer. Cancer Invest. 2009;27:844-50 pubmed publisher
    b>CD133, CD44, and CD166 are cell surface markers that have recently been associated with colorectal cancer stem cells...
  19. Jaksch M, Múnera J, Bajpai R, Terskikh A, Oshima R. Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines. Cancer Res. 2008;68:7882-6 pubmed publisher
    b>CD133 (Prominin1) is a pentaspan transmembrane glycoprotein expressed in several stem cell populations and cancers...
  20. Fan L, He F, Liu H, Zhu J, Liu Y, Yin Z, et al. CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma. BMC Cancer. 2011;11:320 pubmed publisher
    b>CD133 is known to be a cancer stem cell (CSC) marker...
  21. Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Koike Y, et al. Clinical significance of CD133 and hypoxia inducible factor-1? gene expression in rectal cancer after preoperative chemoradiotherapy. Clin Oncol (R Coll Radiol). 2011;23:323-32 pubmed publisher
    ..Therefore, we investigated the correlation between the expression of CD133 and hypoxia inducible factor-1? (HIF-1?), and their association with clinical outcome...
  22. Taïeb N, Maresca M, Guo X, Garmy N, Fantini J, Yahi N. The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif. Cancer Lett. 2009;278:164-173 pubmed publisher
    b>Prominin 1/CD133 is a marker of transplantable cancer stem cells. We have generated anti-peptide antibodies against a N-terminal epitope of CD133 belonging to a ganglioside-binding domain...
  23. Bakondi B, Shimada I, Peterson B, Spees J. SDF-1? secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7. Stem Cells Dev. 2011;20:1021-9 pubmed publisher
    We recently reported that concentrated conditioned medium (CdM) from human CD133-derived bone marrow progenitor cells (CD133 CdM) was neuroprotective after stroke...
  24. Chen Y, Wu M, Huang C, Lin S, Chuang T, Yu C, et al. CD133/Src axis mediates tumor initiating property and epithelial-mesenchymal transition of head and neck cancer. PLoS ONE. 2011;6:e28053 pubmed publisher
    ..Previously, we enriched a subpopulation of head and neck cancer initiating cells (HN-CICs) with up-regulation of CD133 and enhancement of EMT...
  25. Vander Griend D, Karthaus W, Dalrymple S, Meeker A, DeMarzo A, Isaacs J. The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells. Cancer Res. 2008;68:9703-11 pubmed publisher
    ..When epithelial cell suspensions containing cells expressing the stem cell marker CD133+ are inoculated in vivo, regeneration of stratified human prostate glands requires inductive prostate stromal ..
  26. Salnikov A, Gladkich J, Moldenhauer G, Volm M, Mattern J, Herr I. CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non-small cell lung cancer patients. Int J Cancer. 2010;126:950-8 pubmed publisher
    ..CSCs found in many solid tumors express CD133 antigen on the cell surface...
  27. Michaelides M, Gaillard M, Escher P, Tiab L, Bedell M, Borruat F, et al. The PROM1 mutation p.R373C causes an autosomal dominant bull's eye maculopathy associated with rod, rod-cone, and macular dystrophy. Invest Ophthalmol Vis Sci. 2010;51:4771-80 pubmed publisher
  28. Huang X, Sheng Y, Guan M. Co-expression of stem cell genes CD133 and CD44 in colorectal cancers with early liver metastasis. Surg Oncol. 2012;21:103-7 pubmed publisher
    To investigate the expression status and clinical implications of stem cell genes CD133 and CD44 in the colorectal cancers with early liver metastasis...
  29. Pohl A, El Khoueiry A, Yang D, Zhang W, Lurje G, Ning Y, et al. Pharmacogenetic profiling of CD133 is associated with response rate (RR) and progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC), treated with bevacizumab-based chemotherapy. Pharmacogenomics J. 2013;13:173-80 pubmed publisher
    Recent studies suggest CD133, a surface protein widely used for isolation of colon cancer stem cells, to be associated with tumor angiogenesis and recurrence...
  30. Tong Q, Zheng L, Tang S, Ruan Q, Liu Y, Li S, et al. Expression and clinical significance of stem cell marker CD133 in human neuroblastoma. World J Pediatr. 2008;4:58-62 pubmed publisher
    Recent evidences indicate that CD133, a kind of transmembrane protein, can be used as a marker to isolate stem cells from tumors originating from neural crest...
  31. Chen J, Guo T, Zhang L, Qin L, Singer S, Maki R, et al. CD133 and CD44 are universally overexpressed in GIST and do not represent cancer stem cell markers. Genes Chromosomes Cancer. 2012;51:186-95 pubmed publisher
    ..study was aimed to determine whether expression of commonly used stem cell markers in other malignancies, that is, CD133 and CD44, might identify cells with characteristics of cancer stem/progenitor cells in human GIST...
  32. Herpel E, Jensen K, Muley T, Warth A, Schnabel P, Meister M, et al. The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer. Anticancer Res. 2011;31:4491-500 pubmed
    ..In various tumor entities, expression of cancer stem cell (CSC) antigens has been proven to be prognostically unfavorable. However, for lung cancer, the data are scant and conflicting...
  33. Barcelos L, Duplaa C, Krankel N, Graiani G, Invernici G, Katare R, et al. Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res. 2009;104:1095-102 pubmed publisher
    We evaluated the healing potential of human fetal aorta-derived CD133(+) progenitor cells and their conditioned medium (CD133(+) CCM) in a new model of ischemic diabetic ulcer...
  34. Hibi K, Sakata M, Sakuraba K, Shirahata A, Goto T, Mizukami H, et al. CD133 gene overexpression is frequently observed in early colorectal carcinoma. Hepatogastroenterology. 2009;56:995-7 pubmed
    ..been proved that colorectal carcinoma is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells. The present study examined the CD133 gene expression in colorectal carcinomas we surgically removed...
  35. Horn P, Tesch H, Staib P, Kube D, Diehl V, Voliotis D. Expression of AC133, a novel hematopoietic precursor antigen, on acute myeloid leukemia cells. Blood. 1999;93:1435-7 pubmed
  36. Hibi K, Sakata M, Kitamura Y, Sakuraba K, Shirahata A, Goto T, et al. Demethylation of the CD133 gene is frequently detected in early gastric carcinoma. Anticancer Res. 2010;30:1201-3 pubmed
    ..reported that colorectal carcinoma is created and propagated by a small number of undifferentiated tumorigenic CD133(+) cells...
  37. Yan X, Ma L, Yi D, Yoon J, Diercks A, Foltz G, et al. A CD133-related gene expression signature identifies an aggressive glioblastoma subtype with excessive mutations. Proc Natl Acad Sci U S A. 2011;108:1591-6 pubmed publisher
    ..The transmembrane protein CD133 has been widely used to isolate putative CSC populations in several cancer types, but its validity as a CSC marker ..
  38. Maw M, Corbeil D, Koch J, Hellwig A, Wilson Wheeler J, Bridges R, et al. A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. Hum Mol Genet. 2000;9:27-34 pubmed
    ..One such candidate is the gene encoding human prominin (mouse)-like 1 (PROML1, previously known as AC133 antigen) which belongs to the prominin family of 5-transmembrane domain proteins...
  39. Ma S, Chan K, Lee T, Tang K, Wo J, Zheng B, et al. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res. 2008;6:1146-53 pubmed publisher
    ..in our study of cancer stem cells (CSC) in hepatocellular carcinoma (HCC) have led to the identification of CD133 as a prominent HCC CSC marker...
  40. Okudela K, Woo T, Mitsui H, Tajiri M, Masuda M, Ohashi K. Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and ?-catenin, in primary lung adenocarcinoma--their prognostic significance. Pathol Int. 2012;62:792-801 pubmed publisher
    The present study investigated expression profiles of the potential CSC markers including CD133, CD44, ALDH1, and ?-catenin, and evaluated their prognostic value in lung adenocarcinomas...
  41. Wen L, Chen X, Yang K, Chen Z, Zhang B, Chen J, et al. Prognostic value of cancer stem cell marker CD133 expression in gastric cancer: a systematic review. PLoS ONE. 2013;8:e59154 pubmed publisher
    ..the Medline and Chinese CNKI (up to 1 Dec 2011) was performed using the following keywords gastric cancer, CD133, AC133, prominin-1 etc...
  42. Wei X, Zhou L, Cheng L, Tian J, Jiang J, Maccallum J. In vivo investigation of CD133 as a putative marker of cancer stem cells in Hep-2 cell line. Head Neck. 2009;31:94-101 pubmed publisher
    ..Our in vitro experiment shown as CD133, a 5-transmembrane glycoprotein expressed in Hep-2 cell line...
  43. Permanyer J, Navarro R, Friedman J, Pomares E, Castro Navarro J, Marfany G, et al. Autosomal recessive retinitis pigmentosa with early macular affectation caused by premature truncation in PROM1. Invest Ophthalmol Vis Sci. 2010;51:2656-63 pubmed publisher
  44. Zhang Q, Zulfiqar F, Xiao X, Riazuddin S, Ahmad Z, Caruso R, et al. Severe retinitis pigmentosa mapped to 4p15 and associated with a novel mutation in the PROM1 gene. Hum Genet. 2007;122:293-9 pubmed
    ..The mutation was not detected in 192 chromosomes of unrelated control individuals of the same ethnicity and from the same region. This delineates the phenotypic characteristics of retinopathy caused by mutations in PROM1. ..
  45. Huttner H, Janich P, Kohrmann M, Jászai J, Siebzehnrubl F, Blumcke I, et al. The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. Stem Cells. 2008;26:698-705 pubmed
    ..Here, we show that human CSF contains specific membrane particles that carry prominin-1/CD133, a neural stem cell marker implicated in brain tumors, notably glioblastoma...
  46. Shepherd C, Rizzo S, Ledaki I, Davies M, Brewer D, Attard G, et al. Expression profiling of CD133+ and CD133- epithelial cells from human prostate. Prostate. 2008;68:1007-24 pubmed publisher
    Recent evidence suggests that prostate stem cells in benign and tumor tissue express the cell surface marker CD133, but these cells have not been well characterized...
  47. Shimada M, Sugimoto K, Iwahashi S, Utsunomiya T, Morine Y, Imura S, et al. CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma. J Gastroenterol. 2010;45:896-902 pubmed publisher
    b>CD133 is one of the most important cancer-initiating (stem) cell markers and was confirmed to be expressed in solid cancers such as colon cancer...
  48. Arne G, Kristiansson E, Nerman O, Kindblom L, Ahlman H, Nilsson B, et al. Expression profiling of GIST: CD133 is associated with KIT exon 11 mutations, gastric location and poor prognosis. Int J Cancer. 2011;129:1149-61 pubmed publisher
    ..In addition, gene expression profiles for 35 GISTs were analyzed by meta-analysis. Expression of CD133 (prominin-1) protein was examined by tissue microarray (TMA) analysis of 204 GISTs from a population-based study ..
  49. Yu Y, Flint A, Dvorin E, Bischoff J. AC133-2, a novel isoform of human AC133 stem cell antigen. J Biol Chem. 2002;277:20711-6 pubmed
    Human AC133 antigen, also called CD133, was recently identified as a hematopoietic stem cell marker. However, the molecular structure and function of this protein has remained unclear...
  50. Sagrinati C, Netti G, Mazzinghi B, Lazzeri E, Liotta F, Frosali F, et al. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol. 2006;17:2443-56 pubmed
    ..of parietal epithelial cells (PEC) in the Bowman's capsule exhibit coexpression of the stem cell markers CD24 and CD133 and of the stem cell-specific transcription factors Oct-4 and BmI-1, in the absence of lineage-specific markers...
  51. Rebetz J, Tian D, Persson A, Widegren B, Salford L, Englund E, et al. Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma. PLoS ONE. 2008;3:e1936 pubmed publisher
    ..and 17 high-grade glioma specimens were flow-cytometrically analyzed for markers characteristics of stem cells (CD133); glial progenitors (PDGFRalpha, A2B5, O4, and CD44); and late oligodendrocyte progenitors (O1)...
  52. Puglisi M, Barba M, Corbi M, Errico M, Giorda E, Saulnier N, et al. Identification of Endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells. J Pathol. 2011;225:305-14 pubmed publisher
    ..b>CD133 antigen has been proposed as a CSC marker in colon cancer (CC)...
  53. Aomatsu N, Yashiro M, Kashiwagi S, Takashima T, Ishikawa T, Ohsawa M, et al. CD133 is a useful surrogate marker for predicting chemosensitivity to neoadjuvant chemotherapy in breast cancer. PLoS ONE. 2012;7:e45865 pubmed publisher
    ..We hypothesized that a cancer stem cell marker may identify NAC-resistant patients, and evaluated CD133 and ALDH1 as a potential surrogate marker for breast cancer...
  54. Wang K, Xu J, Zhang J, Huang J. Prognostic role of CD133 expression in colorectal cancer: a meta-analysis. BMC Cancer. 2012;12:573 pubmed publisher
    b>CD133 has been identified as a putative cancer stem cell marker in colorectal cancer (CRC). However, the clinical and prognostic significance of CD133 in CRC remains controversial...
  55. Bertolini G, Roz L, Perego P, Tortoreto M, Fontanella E, Gatti L, et al. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc Natl Acad Sci U S A. 2009;106:16281-6 pubmed publisher
    ..b>CD133, a surface glycoprotein linked to organ-specific stem cells, was described as a marker of cancer-initiating cells ..
  56. Elsaba T, Martinez Pomares L, Robins A, Crook S, Seth R, Jackson D, et al. The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. PLoS ONE. 2010;5:e10714 pubmed publisher
    b>CD133 is a membrane molecule that has been, controversially, reported as a CSC marker in colorectal cancer (CRC). In this study, we sought to clarify the expression and role of CD133 in CRC...
  57. Wang Y, Zhu Y, Qiu F, Zhang T, Chen Z, Zheng S, et al. Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells. Carcinogenesis. 2010;31:1376-80 pubmed publisher
    ..However, the molecular mechanism of CSC involved in these events needs to be further elucidated. In this study, CD133(+) colon cancer cells were cultured, which showed CSC properties both in vitro and in vivo from metastatic tissue...
  58. Li G, Liu C, Yuan J, Xiao X, Tang N, Hao J, et al. CD133(+) single cell-derived progenies of colorectal cancer cell line SW480 with different invasive and metastatic potential. Clin Exp Metastasis. 2010;27:517-27 pubmed publisher
    ..b>CD133 (Prominin-1, Prom1) is the marker of human colorectal cancer (CRC) stem cells and probably a marker of metastatic ..
  59. Missol Kolka E, Karbanova J, Janich P, Haase M, Fargeas C, Huttner W, et al. Prominin-1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate. Prostate. 2011;71:254-67 pubmed publisher
    ..A report has shown that human PROMININ-1 carrying the AC133 epitope can be used to identify rare prostate basal stem cells (Richardson et al...
  60. Wei Y, Jiang Y, Zou F, Liu Y, Wang S, Xu N, et al. Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells. Proc Natl Acad Sci U S A. 2013;110:6829-34 pubmed publisher
    The biological significance of a known normal and cancer stem cell marker CD133 remains elusive...
  61. Yin S, Li J, Hu C, Chen X, Yao M, Yan M, et al. CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int J Cancer. 2007;120:1444-50 pubmed
    ..b>CD133 is a putative hematopoietic and neuronal stem-cell marker, which was also considered as a tumorigenic marker in ..
  62. Zhao P, Li Y, Lu Y. Aberrant expression of CD133 protein correlates with Ki-67 expression and is a prognostic marker in gastric adenocarcinoma. BMC Cancer. 2010;10:218 pubmed publisher
    The relationships between the expression of CD133, Ki-67 and prognosis in gastric adenocarcinoma are unknown and needs exploring...
  63. Lugli A, Iezzi G, Hostettler I, Muraro M, Mele V, Tornillo L, et al. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer. 2010;103:382-90 pubmed publisher
    The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer...
  64. Shen W, Zeng Z, Zhu W, Fu G. MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells. J Mol Med (Berl). 2013;91:989-1000 pubmed publisher
    Studies have shown that the expression of CD133, leucine-rich-repeat-containing G-protein-coupled receptor 5 (Lgr5), and ATP binding cassette (ABC)G2 proteins is associated with malignancy and poor prognosis in colon cancer...
  65. Ohnishi S, Maehara O, Nakagawa K, Kameya A, Otaki K, Fujita H, et al. hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors. PLoS ONE. 2013;8:e66255 pubmed publisher
    b>CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus it is considered to be a potential target for cancer treatment. However, the mechanism regulating CD133 expression is not yet understood...
  66. Corbeil D, Fargeas C, Huttner W. Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein. Biochem Biophys Res Commun. 2001;285:939-44 pubmed
  67. Yu J, Zhang P, Wu J, Wu S, Li X, Wang S, et al. Expressions and clinical significances of CD133 protein and CD133 mRNA in primary lesion of gastric adenocacinoma. J Exp Clin Cancer Res. 2010;29:141 pubmed publisher
    To study on expressions and clinical significances of CD133 protein and CD133 mRNA in primary lesion of gastric adenocarcinoma (GC)...
  68. Kim M, Fleming J, Wang H, Abbruzzese J, Choi W, Kopetz S, et al. ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PLoS ONE. 2011;6:e20636 pubmed publisher
    ..We have isolated populations of cells with high ALDH activity (ALDH(high)) and/or CD133 cell surface expression from human xenograft tumors established from multiple patient tumors with pancreatic ..
  69. Rocco A, Liguori E, Pirozzi G, Tirino V, Compare D, Franco R, et al. CD133 and CD44 cell surface markers do not identify cancer stem cells in primary human gastric tumors. J Cell Physiol. 2012;227:2686-93 pubmed publisher
    ..By using CD133 and CD44 cell surface markers we investigated whether primary human GCs contain a cell subset expressing stem-like ..
  70. Qu H, Li R, Liu Z, Zhang J, Luo R. Prognostic value of cancer stem cell marker CD133 expression in non-small cell lung cancer: a systematic review. Int J Clin Exp Pathol. 2013;6:2644-50 pubmed
    To investigate the correlation between CD133-positive non-small cell lung cancer (NSCLC) and clinicopathological features and its impact on survival...
  71. Yin A, Miraglia S, Zanjani E, Almeida Porada G, Ogawa M, Leary A, et al. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood. 1997;90:5002-12 pubmed
    b>AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD...
  72. Shu Q, Wong K, Su J, Adesina A, Yu L, Tsang Y, et al. Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma. Stem Cells. 2008;26:1414-24 pubmed publisher
    ..More importantly, the CD133(+) tumor cells, ranging from 0.2%-10...
  73. Li C, Li B, Liang Y, Peng R, Ding Y, Xu D, et al. Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB. J Transl Med. 2009;7:56 pubmed publisher
    ..To evaluate the overpopulation hypothesis of cancer stem cells the association of percentage of CD133+ tumor cells with clinicopathological parameters in colon cancer was investigated since CD133 is a putative cancer ..
  74. Metellus P, Nanni Metellus I, Delfino C, Colin C, Tchogandjian A, Coulibaly B, et al. Prognostic impact of CD133 mRNA expression in 48 glioblastoma patients treated with concomitant radiochemotherapy: a prospective patient cohort at a single institution. Ann Surg Oncol. 2011;18:2937-45 pubmed publisher
    ..The CD133 antigen has been described as a putative stem cell marker in malignant brain tumor that could identify such a ..
  75. Hashimoto O, Shimizu K, Semba S, Chiba S, Ku Y, Yokozaki H, et al. Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1?-dependent manner in pancreatic cancer cells. Pathobiology. 2011;78:181-92 pubmed publisher
    ..Under normoxia (20% O(2)) or hypoxia (1% O(2)), the expression of CD133 (cancer stem cell marker), CXC chemokine receptor 4 (CXCR4) and hypoxia-inducible factor-1? (HIF-1?) was examined ..
  76. Richardson G, Robson C, Lang S, Neal D, Maitland N, Collins A. CD133, a novel marker for human prostatic epithelial stem cells. J Cell Sci. 2004;117:3539-45 pubmed
    ..Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker...
  77. Fargeas C, Huttner W, Corbeil D. Nomenclature of prominin-1 (CD133) splice variants - an update. Tissue Antigens. 2007;69:602-6 pubmed publisher
    Prominin-1 (CD133), a pentaspan membrane glycoprotein that constitutes an important cell surface marker of various, either normal or cancerous, stem cell populations is widely used to isolate or characterize such cells in different ..
  78. Ferrandina G, Martinelli E, Petrillo M, Prisco M, Zannoni G, Sioletic S, et al. CD133 antigen expression in ovarian cancer. BMC Cancer. 2009;9:221 pubmed publisher
    ..In this context, CD133 antigen has proved to be a marker of tumor cells with stemness features in several human malignancies...
  79. Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Ioue Y, et al. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann Surg Oncol. 2009;16:3488-98 pubmed publisher
    ..We investigated the role of three stem cell markers (CD133, OCT4, and SOX2) in rectal cancer and evaluated the association between these gene levels and clinical outcome in ..
  80. Wu S, Yu L, Wang D, Zhou L, Cheng Z, Chai D, et al. Aberrant expression of CD133 in non-small cell lung cancer and its relationship to vasculogenic mimicry. BMC Cancer. 2012;12:535 pubmed publisher
    To investigate on expressions and clinical significances of CD133 protein and vasculogenic mimicry (VM) in primary non-small cell lung cancer (NSCLC)...
  81. Ferrandina G, Bonanno G, Pierelli L, Perillo A, Procoli A, Mariotti A, et al. Expression of CD133-1 and CD133-2 in ovarian cancer. Int J Gynecol Cancer. 2008;18:506-14 pubmed
    ..Stem cells isolated from nervous system and prostate express CD133 antigen, which is widely used to isolate hematopoietic stem and progenitor cells...
  82. Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, et al. Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest. 2008;118:2908-16 pubmed publisher
    ..Here we show that an R373C missense mutation in the prominin 1 gene (PROM1) causes 3 forms of autosomal-dominant macular degeneration...
  83. Yi J, Tsai H, Glöckner S, Lin S, Ohm J, Easwaran H, et al. Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res. 2008;68:8094-103 pubmed publisher
    ..We report here an unusual promoter DNA methylation pattern for one such marker, the cell surface antigen CD133 (Prominin 1)...
  84. Rutella S, Bonanno G, Procoli A, Mariotti A, Corallo M, Prisco M, et al. Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors. Clin Cancer Res. 2009;15:4299-311 pubmed publisher
    ..The present study aimed to determine whether CD133 expression may identify cells with characteristics of cancer stem/progenitor cells in human endometrial tumors...
  85. Yasuda H, Tanaka K, Saigusa S, Toiyama Y, Koike Y, Okugawa Y, et al. Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer. Oncol Rep. 2009;22:709-17 pubmed
    b>CD133 has been postulated to be a colon cancer stem cell (CSCs) marker. Recent investigations suggest that CSCs might contribute to cancer recurrence and resistance to conventional therapies...
  86. You H, Ding W, Rountree C. Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta. Hepatology. 2010;51:1635-44 pubmed publisher
    Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. CD133, a transmembrane glycoprotein, is an important cell surface marker for both stem cells and cancer stem cells in various tissues including ..
  87. Nakamura M, Kyo S, Zhang B, Zhang X, Mizumoto Y, Takakura M, et al. Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer. Hum Pathol. 2010;41:1516-29 pubmed publisher
    ..The present study dissected the roles of CD133 as a tumor-initiating cell marker in endometrial cancer and investigated the prognostic impact of this marker ..
  88. Campos B, Herold Mende C. Insight into the complex regulation of CD133 in glioma. Int J Cancer. 2011;128:501-10 pubmed publisher
    The transmembrane protein CD133 and its extracellular epitope AC133 are controversial cancer markers...