CD13

Summary

Gene Symbol: CD13
Description: alanyl aminopeptidase, membrane
Alias: APN, CD13, GP150, LAP1, P150, PEPN, aminopeptidase N, AP-M, AP-N, alanyl (membrane) aminopeptidase, aminopeptidase M, hAPN, membrane alanyl aminopeptidase, microsomal aminopeptidase, myeloid plasma membrane glycoprotein CD13
Species: human
Products:     CD13

Top Publications

  1. Petrovic N, Bhagwat S, Ratzan W, Ostrowski M, Shapiro L. CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells. J Biol Chem. 2003;278:49358-68 pubmed
    CD13/aminopeptidase N (CD13/APN) is a potent regulator of angiogenesis both in vitro and in vivo and transcription of CD13/APN in endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway...
  2. Miki T, Takegami Y, Okawa K, Muraguchi T, Noda M, Takahashi C. The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways. J Biol Chem. 2007;282:12341-52 pubmed
    ..Subsequently, we found that RECK interacts with CD13/aminopeptidase N. Further, we found that RECK inhibits the proteolytic activity of CD13 in a cholesterol perturbation-..
  3. Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, et al. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res. 2000;60:722-7 pubmed
    ..We show here that the receptor for the NGR peptides in tumor vasculature is aminopeptidase N (APN; also called CD13)...
  4. Bhagwat S, Petrovic N, Okamoto Y, Shapiro L. The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis. Blood. 2003;101:1818-26 pubmed
    ..The CD13/aminopeptidase N (CD13/APN) metalloprotease is an important regulator of angiogenesis where its expression on activated blood ..
  5. Mina Osorio P, Ortega E. Aminopeptidase N (CD13) functionally interacts with FcgammaRs in human monocytes. J Leukoc Biol. 2005;77:1008-17 pubmed
    b>Aminopeptidase N (E.C. 3.4.11.2) is a membrane-bound metalloproteinase expressed in many tissues...
  6. Chang Y, Chen S, Cheng E, Ko Y, Lin Y, Kao Y, et al. CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells. Int J Cancer. 2005;116:243-52 pubmed
    ..We now report that CD13 (aminopeptidase N) can associate with TAL6 and can enhance cancer cell migration...
  7. Yang E, Shim J, Woo H, Kim K, Kwon H. Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3. Biochem Biophys Res Commun. 2007;363:336-41 pubmed
    b>Aminopeptidase N/CD13 is an endothelial cell surface ectoenzyme involved in one of the initial steps of angiogenesis. However, little is known how APN induces angiogenesis in endothelial cells...
  8. Wulfänger J, Schneider H, Wild P, Ikenberg K, Rodolfo M, Rivoltini L, et al. Promoter methylation of aminopeptidase N/CD13 in malignant melanoma. Carcinogenesis. 2012;33:781-90 pubmed publisher
    b>Aminopeptidase N (APN)/CD13 as ubiquitously expressed membrane peptidase exerts important functions in diverse cellular processes, such as proliferation, migration and differentiation...
  9. Wong A, Zhou D, Rini J. The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing. J Biol Chem. 2012;287:36804-13 pubmed publisher
    Human aminopeptidase N (hAPN/hCD13) is a dimeric membrane protein and a member of the M1 family of zinc metallopeptidases...

More Information

Publications117 found, 100 shown here

  1. Shapiro L, Ashmun R, Roberts W, Look A. Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells. J Biol Chem. 1991;266:11999-2007 pubmed
    b>Aminopeptidase N is a membrane-bound metalloprotease expressed on the surface of normal and malignant human myeloid cells, fibroblasts, hepatocytes, and the epithelial cells that form brush borders of the small intestine and kidney...
  2. Hirano T, Kizaki M, Kato K, Abe F, Masuda N, Umezawa K. Enhancement of sensitivity by bestatin of acute promyelocytic leukemia NB4 cells to all-trans retinoic acid. Leuk Res. 2002;26:1097-103 pubmed
    ..We found that bestatin, an inhibitor of CD13/aminopeptidase N, enhanced the sensitivity of APL NB4 cells to ATRA at concentrations of 0.1-1000ng/ml...
  3. Lendeckel U, Arndt M, Bukowska A, Tadje J, Wolke C, Kahne T, et al. Synergistic action of DPIV and APN in the regulation of T cell function. Adv Exp Med Biol. 2003;524:123-31 pubmed
    ..have been observed in response to inhibition of DPIV, which is strongly suggestive of a functional synergism of APN and DPIV...
  4. Fontijn D, Duyndam M, van Berkel M, Yuana Y, Shapiro L, Pinedo H, et al. CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells. Br J Cancer. 2006;94:1627-36 pubmed
    CD13/Aminopeptidase N (CD13) is known to play an important role in tumour cell invasion. We examined whether basic fibroblast growth factor (bFGF) is involved in the regulation of CD13 expression in human melanoma cells...
  5. Tokuhara T, Hattori N, Ishida H, Hirai T, Higashiyama M, Kodama K, et al. Clinical significance of aminopeptidase N in non-small cell lung cancer. Clin Cancer Res. 2006;12:3971-8 pubmed
    ..A monoclonal antibody MH8-11, which we established, recognizes a glycoprotein that is identical to aminopeptidase N (APN/CD13)...
  6. Petrovic N, Schacke W, Gahagan J, O Conor C, Winnicka B, Conway R, et al. CD13/APN regulates endothelial invasion and filopodia formation. Blood. 2007;110:142-50 pubmed
    CD13/aminopeptidase N is a transmembrane peptidase that is induced in the vasculature of solid tumors and is a potent angiogenic regulator...
  7. Terauchi M, Kajiyama H, Shibata K, Ino K, Nawa A, Mizutani S, et al. Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells. BMC Cancer. 2007;7:140 pubmed
    b>Aminopeptidase N (APN/CD13), a 150-kDa metalloprotease, is a multifunctional cell surface aminopeptidase with ubiquitous expression...
  8. Mawrin C, Wolke C, Haase D, Krüger S, Firsching R, Keilhoff G, et al. Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC. Brain Pathol. 2010;20:200-10 pubmed publisher
    ..In this study, we examined the expression and function of the membrane alanyl-aminopeptidase [mAAP, aminopeptidase N (APN), CD13, EC3.4.11...
  9. Perez I, Varona A, Blanco L, Gil J, Santaolalla F, Zabala A, et al. Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma. Head Neck. 2009;31:1335-40 pubmed publisher
    ..The catalytic activity for a pool of peptidases (PSA, APN/CD13, APB, APA, Asp-AP, CAP, DPPIV/CD26, NEP/CD10, and PGI) was measured fluorometrically...
  10. Vaswani K, Chan H, Verma P, Dekker Nitert M, Peiris H, Wood Bradley R, et al. The rat placental renin-angiotensin system - a gestational gene expression study. Reprod Biol Endocrinol. 2015;13:89 pubmed publisher
    ..These findings present the need for further comprehensive investigation of RAS genes in normal and complicated pregnancies. ..
  11. González Bacerio J, Maluf S, Méndez Y, Pascual I, Florent I, Melo P, et al. KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library. Bioorg Med Chem. 2017;25:4628-4636 pubmed publisher
    ..At therapeutic-relevant concentrations, KBE009 is selective for rPfA-M1 over porcine APN (a model of these enzymes from mammals), and is not cytotoxic against HUVEC cells...
  12. Corvan S, Agnew L, Andronicos N. Trichostrongylus colubriformis induces IgE-independent CD13, CD164 and CD203c mediated activation of basophils in an in vitro intestinal epithelial cell co-culture model. Vet Parasitol. 2015;207:285-96 pubmed publisher
    ..Cell surface expression of CD164, CD107a and CD13 antigens on gated CD203(+) cells were determined and qRT-PCR was used to examine gene expression changes of IL33 (a ..
  13. Sánchez Agesta Ortega R, Arias de Saavedra Alías J, Liebana Cañada A, Sánchez Muñoz B, Martinez Martos J, Ramírez Expósito M. Circulating aminopeptidase activities in men and women with essential hypertension. Curr Med Chem. 2013;20:4935-45 pubmed
    ..of several proteolytic regulatory enzymes related to renin-angiotensin-system (RAS) (aminopeptidase A, APA; aminopeptidase N, APN; aminopeptidase B, APB; and insulin-regulated aminopeptidase, IRAP); with oxytocin regulation (..
  14. Ali D, El Sayyad H, Moftah O, Chilibeck P. Structural and functional abnormalities of hepatic tissues in male Wistar rats fed hyperwhey and super amino anabolic protein. Nutrition. 2016;32:840-8 pubmed publisher
    ..5 g/kg body weight), and super amino 2500 (SA) (APN, Ft. Launderale, FL, USA) (2.5 g/kg body weight)...
  15. Li X, Guo H, Zhao L, Wang B, Liu H, Yue L, et al. Adiponectin attenuates NADPH oxidase-mediated oxidative stress and neuronal damage induced by cerebral ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3265-3276 pubmed publisher
    Adiponectin (APN), which is a major adipokine that regulated glucose and lipid metabolism, plays an important role in the protection of the cerebral nervous system...
  16. Xu S, Wang D, Zhang P, Lin Y, Fang Z, Che L, et al. Oral administration of Lactococcus lactis-expressed recombinant porcine epidermal growth factor stimulates the development and promotes the health of small intestines in early-weaned piglets. J Appl Microbiol. 2015;119:225-35 pubmed publisher
    ..1 (CLDN1), occludin and zonula occludens 1 (ZO-1), the digestive enzymes sucrose, aminopeptidase A, and aminopeptidase N, and the nutrient transporters sodium/glucose cotransporter 1 (SGLT1), glucose transporter 2, and peptide ..
  17. Wang S, Wu M, Chen K, Liu Y, Sun J, Sun Z, et al. Hawthorn Extract Alleviates Atherosclerosis through Regulating Inflammation and Apoptosis Related Factors: An Experimental Study. Chin J Integr Med. 2019;25:108-115 pubmed publisher
    ..Plasma levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-1β (IL-1β), adiponectin (APN), and hypersensitive C-reactive protein (hs-CRP) were measured by enzyme-linked immunosorbent assay (ELISA)...
  18. Liu X, Huang K, Hou Q, Sun Z, Wang B, Lin G, et al. Identification and characterization of a constitutively expressed Ctenopharyngodon idella ADAR1 splicing isoform (CiADAR1a). Dev Comp Immunol. 2016;63:10-7 pubmed publisher
    ..There are many ADAR1 splicing isoforms in mammals, including an interferon (IFN) inducible ?150 kD protein (ADAR1-p150) and a constitutively expressed ?110 kD protein (ADAR1-p110)...
  19. den Boer M, Kapaun P, Pieters R, Kazemier K, Janka Schaub G, Veerman A. Myeloid antigen co-expression in childhood acute lymphoblastic leukaemia: relationship with in vitro drug resistance. Br J Haematol. 1999;105:876-82 pubmed
    ..thiazol tetrazoliumbromide (MTT) assay was used to compare the in vitro cytotoxicity of 14 drugs between 60 My+ (CD13+ and/or CD33+) and 107 My- ALL children at initial diagnosis...
  20. Li Y, Nguyen D, de Waard M, Christensen L, Zhou P, Jiang P, et al. Pasteurization Procedures for Donor Human Milk Affect Body Growth, Intestinal Structure, and Resistance against Bacterial Infections in Preterm Pigs. J Nutr. 2017;147:1121-1130 pubmed publisher
    ..05) and a tendency for higher aminopeptidase N (48%) and claudin-4 (26%) concentrations in the distal intestine (P < 0.08)...
  21. Duan J, Yin Y, Cui J, Yan J, Zhu Y, Guan Y, et al. Chikusetsu Saponin IVa Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice via Adiponectin-Mediated AMPK/GSK-3β Pathway In Vivo and In Vitro. Mol Neurobiol. 2016;53:728-743 pubmed publisher
    ..Apoptosis was analyzed by caspase-3, Bax, and Bcl-2 expression. Downstream molecules of adiponectin (APN) were investigated by Western blotting...
  22. Yamasaki S, Mendes M, Alponti R, Silveira P. Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: a comparison with methotrexate. Toxicon. 2015;98:75-88 pubmed publisher
    ..alpha (TNF-α) and anti-type II collagen antibodies (AACII), and altered activity of basic (APB) and neutral (APN) aminopeptidases and dipeptidyl peptidase IV (DPPIV) are present in arthritic rats...
  23. Plubell D, Wilmarth P, Zhao Y, Fenton A, Minnier J, Reddy A, et al. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017;16:873-890 pubmed publisher
    ..Data are available via ProteomeXchange with identifier PXD005953. ..
  24. Krjutškov K, Katayama S, Saare M, Vera Rodriguez M, Lubenets D, Samuel K, et al. Single-cell transcriptome analysis of endometrial tissue. Hum Reprod. 2016;31:844-53 pubmed publisher
    ..The frozen-thawed endometrial biopsies were fluorescence-activated cell sorted (FACS) to distinguish CD13-positive stromal and CD9-positive epithelial cells and single-cell transcriptome analysis performed from biopsied ..
  25. Yoshioka M, Erickson R, Woodley J, Gulli R, Guan D, Kim Y. Role of rat intestinal brush-border membrane angiotensin-converting enzyme in dietary protein digestion. Am J Physiol. 1987;253:G781-6 pubmed
    ..were comparable to those observed when major digestive peptidases of the brush-border membrane such as aminopeptidase N and dipeptidyl aminopeptidase IV were assayed...
  26. Smith C, Matheson T, Trombly D, Sun X, Campeau E, Han X, et al. A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli. Mol Biol Cell. 2014;25:2866-81 pubmed publisher
    ..Here we present a novel role for the human p150 subunit in regulating nucleolar macromolecular interactions...
  27. Wang R, Sun Q, Wang P, Liu M, Xiong S, Luo J, et al. Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells. Oncotarget. 2016;7:5754-68 pubmed publisher
    ..In this study, we demonstrate that LCSCs with markers CD90, CD24, CD13, and CD133 possess stem properties of self-renewal and tumorigenicity in NOD/SCID mice...
  28. Zhao W, Wu C, Li S, Chen X. Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways. Cytokine. 2016;88:167-176 pubmed publisher
    ..Adiponectin (APN), an adipocyte-secreted hormone from adipose tissues, showed cardioprotective effects...
  29. Krumpel M, Reithmeier A, Senge T, Baeumler T, Frank M, Nyholm P, et al. The small chemical enzyme inhibitor 5-phenylnicotinic acid/CD13 inhibits cell migration and invasion of tartrate-resistant acid phosphatase/ACP5-overexpressing MDA-MB-231 breast cancer cells. Exp Cell Res. 2015;339:154-62 pubmed publisher
    ..We conclude that one of the three compounds i.e. 5-phenylnicotinic acid (CD13) was efficient as a TRAP inhibitor with Kic values in the low micromolar range towards the TRAP 5b isoform, but was ..
  30. Walker D, Polancich S. Doctor of Nursing Practice: The Role of the Advanced Practice Nurse. Semin Oncol Nurs. 2015;31:263-72 pubmed publisher
    To explore the evolution and emerging roles of the Doctor of Nursing Practice (DNP) Advanced Practice Nurse (APN). Published peer reviewed literature, cancer-related professional resources, and Web-based resources...
  31. Azuma N, Zaslavskaya N, Yamazaki T, Nobetsu T, Chiba S. Phylogeography of Littorina sitkana in the northwestern Pacific Ocean: evidence of eastward trans-Pacific colonization after the Last Glacial Maximum. Genetica. 2017;145:139-149 pubmed publisher
    ..To confirm these results, we compared sequences of the longest intron of the aminopeptidase N gene (APN54) in the nuclear genome in four populations of L...
  32. Hosaka Y, Inoshita T, Shiba Fukushima K, Cui C, Arano T, Imai Y, et al. Reduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome. EBioMedicine. 2017;21:218-227 pubmed publisher
    Parkinsonian Perry syndrome, involving mutations in the dynein motor component dynactin or p150Glued, is characterized by TDP-43 pathology in affected brain regions, including the substantia nigra...
  33. Faletti R, Gatti M, Bassano S, Finocchietti D, Fiore S, Colla L, et al. Follow-up of acute pyelonephritis: what causes the diffusion-weighted magnetic resonance imaging recovery to lag clinical recovery?. Abdom Radiol (NY). 2018;43:639-646 pubmed publisher
    ..magnetic resonance imaging (DW-MRI) the evolution and progress to resolution of acute pyelonephritis (APN) foci over a period of 3 months after onset...
  34. Freeman M, Burkum C, Lanzer K, Jensen M, Ahmed M, Yager E, et al. Cutting edge: activation of virus-specific CD4 T cells throughout ?-herpesvirus latency. J Immunol. 2011;187:6180-4 pubmed publisher
    ..We previously identified a murine MHC class II-restricted epitope in ?-herpesvirus-68 gp150 (gp150(67-83)I-A(b)) that elicits CD4 T cells that are maintained throughout long-term infection...
  35. Patenaude A, Woerher S, Umlandt P, Wong F, Ibrahim R, Kyle A, et al. A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation. Microvasc Res. 2015;101:38-47 pubmed publisher
    ..potential to differentiate into pericytes and have increased expression of classic mesenchymal stem cell markers (CD13, CD44, Nt5e and Thy-1) compared to Sca1(-/lo)/CD146(-)/CD45(-)/CD31(-) cells...
  36. Jung S, Lee J. Prediction of Cortical Defect Using C-Reactive Protein and Urine Sodium to Potassium Ratio in Infants with Febrile Urinary Tract Infection. Yonsei Med J. 2016;57:103-10 pubmed publisher
    ..protein-creatinine ratio (uProt/Cr), and urine electrolytes can be useful for discriminating acute pyelonephritis (APN) from other febrile illnesses or the presence of a cortical defect on 99mTc dimercaptosuccinic acid (DMSA) scanning ..
  37. Van Pham P, Truong N, Le P, Tran T, Vu N, Bui K, et al. Isolation and proliferation of umbilical cord tissue derived mesenchymal stem cells for clinical applications. Cell Tissue Bank. 2016;17:289-302 pubmed publisher
    ..of UC-MSCs at passage 5 such as osteoblast, chondroblast and adipocyte differentiation, and markers including CD13, CD14, CD29, CD34, CD44, CD45, CD73, CD90, CD105, and HLA-DR were confirmed...
  38. Węglarz Tomczak E, Berlicki Ł, Pawełczak M, Nocek B, Joachimiak A, Mucha A. A structural insight into the P1S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases. Eur J Med Chem. 2016;117:187-96 pubmed publisher
    ..g., Ki = 65 nM of 1u for HsAPN). Two structures of an M1 representative (APN from Neisseria meningitidis) in complex with N-benzyl-1,2-diaminoethylphosphonic acid and N-cyclohexyl-1,2-..
  39. Serrano J, Martins F, Sousa J, Pereira C, van Pelt A, Rebelo S, et al. Descriptive Analysis of LAP1 Distribution and That of Associated Proteins throughout Spermatogenesis. Membranes (Basel). 2017;7: pubmed publisher
    ..b>LAP1 is an important NE protein whose function has not been fully elucidated, but several binding partners allow ..
  40. Yang B, Hu P, Lin X, Han W, Zhu L, Tan X, et al. PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas. Cell Mol Life Sci. 2015;72:4383-97 pubmed publisher
    ..Initially, we found that the ADAR1 p150 or p110 transcript levels were decreased in glioma cells compared with normal astrocyte cells...
  41. Sastre Fullana P, Morales Asencio J, Sesé Abad A, Bennasar Veny M, Fernández Domínguez J, de Pedro Gómez J. Advanced Practice Nursing Competency Assessment Instrument (APNCAI): clinimetric validation. BMJ Open. 2017;7:e013659 pubmed publisher
    ..content consensus through qualitative Delphi method approach (a panel of 51 Advanced Practice in Nursing -APN- experts was selected) and the clinimetric validation process based on a sample of 600 nurses from the Balearic ..
  42. Wang H, Yan W, Zhang J, Zhang F, Gao C, Wang Y, et al. Adiponectin partially rescues high glucose/high fat-induced impairment of mitochondrial biogenesis and function in a PGC-1α dependent manner. Eur Rev Med Pharmacol Sci. 2017;21:590-599 pubmed
    Plasma adiponectin (APN) levels are decreased in diabetic patients. Dysfunctional mitochondrial biogenesis is involved in type 2 diabetes (T2DM) pathogenesis, by unclear mechanisms...
  43. Luetragoon T, Rutqvist L, Tangvarasittichai O, Andersson B, Lofgren S, Usuwanthim K, et al. Interaction among smoking status, single nucleotide polymorphisms and markers of systemic inflammation in healthy individuals. Immunology. 2018;154:98-103 pubmed publisher
    ..phenotypes that are associated with an immunocompromised state: CD8dim cells in the lymphocyte group, CD13 CD11+ , CD13 CD14+ , CD13 CD56+ cells in ..
  44. Wang S, Liu J, Zhang J, Lin J, YANG S, Yao J, et al. Glycemic control and adipokines after periodontal therapy in patients with Type 2 diabetes and chronic periodontitis. Braz Oral Res. 2017;31:e90 pubmed publisher
    ..status, blood glucose, and the levels of serum tumor necrosis factor ? (TNF-?), interleukin-6 (IL-6), adiponectin (APN), and fibroblast growth factor-21 (FGF-21) were measured at baseline and after 3 months...
  45. Uwada J, Tanaka N, Yamaguchi Y, Uchimura Y, Shibahara K, Nakao M, et al. The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci. Biochem Biophys Res Commun. 2010;391:407-13 pubmed publisher
    ..Here we report that the largest subunit of chromatin assembly factor 1 (CAF-1), human p150, interacts directly and preferentially with SUMO2/3...
  46. Wu Z, Cui F, Yu F, Peng X, Jiang T, Chen D, et al. Up-regulation of CHAF1A, a poor prognostic factor, facilitates cell proliferation of colon cancer. Biochem Biophys Res Commun. 2014;449:208-15 pubmed publisher
    Deregulation of chromatin assembly factor 1, p150 subunit A (CHAF1A) has recently been reported to be involved in the development of some cancer types...
  47. Shan Z, Yin J, Wang Z, Chen P, Li Y, Tang L. Identification of the functional domain of the porcine epidemic diarrhoea virus receptor. J Gen Virol. 2015;96:2656-60 pubmed publisher
    Porcine aminopeptidase N (pAPN) is a functional receptor for porcine epidemic diarrhoea virus (PEDV)...
  48. Gerber C, Harel M, Lynch M, Herbst K, Ferrer F, Shapiro L. Proximal tubule proteins are significantly elevated in bladder urine of patients with ureteropelvic junction obstruction and may represent novel biomarkers: A pilot study. J Pediatr Urol. 2016;12:120.e1-7 pubmed publisher
    ..We determined levels of NGAL, KIM-1 (previously identified biomarkers), CD10, CD13, and CD26 (potentially novel biomarkers) by ELISA in control and experimental urine samples...
  49. Chen F, Hu Y, Wang X, Fu S, Fu Y, Liu X, et al. [Immunophenotypic Analysis of Acute Promyelocytic Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:321-5 pubmed publisher
    ..the immunophenotypes of R3 was cheracteried by high SSC, weaker expression of CD45, the rate of CD38, CD9 and CD13 all was 100%, moreover their bright expression (>80%) was 86.05%, 90.70% and 86...
  50. Fokin A, Klementeva T, Nadezhdina E, Burakov A. SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization. Cytoskeleton (Hoboken). 2016;73:83-92 pubmed publisher
    ..regulator of cell locomotion that primarily acts through the small GTPase RhoA and the dynactin subunit p150(Glued)...
  51. Gray G, Mayer K, Elizaga M, Bekker L, Allen M, Morris L, et al. Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap. Clin Vaccine Immunol. 2016;23:496-506 pubmed publisher
    ..South African AIDS Vaccine Initiative (SAAVI) HIV-1 subtype C (HIV-1C) DNA vaccine encoding Gag-RT-Tat-Nef and gp150, boosted with modified vaccinia Ankara (MVA) expressing matched antigens...
  52. Cadmus E, Johansen M, Zimmer P, Knowlton D. Entrepreneurship: Assessing the Readiness of the New Jersey APN Workforce. Nurs Adm Q. 2017;41:48-55 pubmed
    ..work in a structured environment where the employer focuses on the business aspects of the practice and the APN focuses primarily on clinical care...
  53. Hennersdorf F, Florian S, Jakob A, Baumgärtner K, Sonneck K, Nordheim A, et al. Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation. Cell Res. 2005;15:325-35 pubmed
    ..and WS-80162, clone 67D2), as well as two reagents with previously unknown specificities that were identified as CD13 (WS-80274, clone A8) and CD107a (WS-80280, clone E63-880)...
  54. Danziger R. Aminopeptidase N in arterial hypertension. Heart Fail Rev. 2008;13:293-8 pubmed
    b>Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system...
  55. Fransen J, Pangeni G, Pyle I, McCall M. Functional changes in Tg P23H-1 rat retinal responses: differences between ON and OFF pathway transmission to the superior colliculus. J Neurophysiol. 2015;114:2368-75 pubmed publisher
    ..At P150, metabotropic glutamate receptor 6 (mGluR6) expression is lower than in WT, consistent with a decrease in ON RGC ..
  56. Schenk S, Minda J, Lech R, Suchan B. Out of sight, out of mind: Categorization learning and normal aging. Neuropsychologia. 2016;91:222-233 pubmed publisher
    ..The categorization of exceptions was accompanied by higher P150, P250 and P300 amplitudes...
  57. Ren H, Li X, Ni Z, Niu J, Cao B, Xu J, et al. Treatment of complicated urinary tract infection and acute pyelonephritis by short-course intravenous levofloxacin (750 mg/day) or conventional intravenous/oral levofloxacin (500 mg/day): prospective, open-label, randomized, controlled, multicenter, . Int Urol Nephrol. 2017;49:499-507 pubmed publisher
    ..of LVFX 500 mg in patients from China with complicated urinary tract infections (cUTIs) and acute pyelonephritis (APN). This was a prospective, open-label, randomized, controlled, multicenter, non-inferiority clinical trial...
  58. Zhang J, Guo L, Xu Y, Yang L, Shi H, Feng L, et al. Characterization of porcine epidemic diarrhea virus infectivity in human embryonic kidney cells. Arch Virol. 2017;162:2415-2419 pubmed publisher
    ..Furthermore, we revealed that aminopeptidase N was involved in PEDV infection in HEK293 cells...
  59. Gasbarrino K, Gorgui J, Nauche B, Cote R, Daskalopoulou S. Circulating adiponectin and carotid intima-media thickness: A systematic review and meta-analysis. Metabolism. 2016;65:968-86 pubmed publisher
    Adiponectin (APN) is an adipokine with insulin-sensitizing, anti-inflammatory, and vasculoprotective properties. Hypoadiponectinemia has been linked with disease states, such as obesity, type 2 diabetes, and cardiovascular disease...
  60. Zou W, Xiao Z, Wen X, Luo J, Chen S, Cheng Z, et al. The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-?B pathway. BMC Complement Altern Med. 2016;16:483 pubmed
    Andrographis paniculata (Burm. f.) Nees (APN), a principal constituent of a famous traditional Chinese medicine Fukeqianjin tablet which is used for the treatment of pelvic inflammatory disease (PID), has been reported to have anti-..
  61. Soboleva T, Parker B, Nekrasov M, Hart Smith G, Tay Y, Tng W, et al. A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B. PLoS Genet. 2017;13:e1006633 pubmed publisher
    ..We have immunoprecipitated the mouse orthologue of H2A.B, H2A.B.3 (H2A.Lap1), from testis chromatin and found this variant to be associated with RNA processing factors and RNA Polymerase (Pol)..
  62. Ivanovska A, Grolli S, Borghetti P, Ravanetti F, Conti V, De Angelis E, et al. Immunophenotypical characterization of canine mesenchymal stem cells from perivisceral and subcutaneous adipose tissue by a species-specific panel of antibodies. Res Vet Sci. 2017;114:51-58 pubmed publisher
    ..ability and RT-PCR analysis (CD90+, CD73+, CD105+, CD44+, CD13+, CD29+, Oct-4+ gene and CD31- and CD45- expression)...
  63. Zeippen C, Javaux J, Xiao X, Ledecq M, Mast J, Farnir F, et al. The Major Envelope Glycoprotein of Murid Herpesvirus 4 Promotes Sexual Transmission. J Virol. 2017;91: pubmed publisher
    ..We show that this depends on the major virion envelope glycoprotein gp150. gp150 is redundant for host entry, and in vitro, it regulates rather than promotes cell binding...
  64. Nicolas S, Cazareth J, Zarif H, Guyon A, Heurteaux C, Chabry J, et al. Globular Adiponectin Limits Microglia Pro-Inflammatory Phenotype through an AdipoR1/NF-?B Signaling Pathway. Front Cell Neurosci. 2017;11:352 pubmed publisher
    We recently reported that increased levels of Adiponectin (ApN) in the brain led to microglia phenotype and activation state regulation, thus reducing both global brain inflammation and depressive-like behaviors in mice...
  65. Tokioka Terao M, Hiwada K, Kokubu T. Purification and characterization of aminopeptidase N from human plasma. Enzyme. 1984;32:65-75 pubmed
    Human plasma aminopeptidase N (EC 3.4.11.2) was homogeneously purified from outdated bank plasma...
  66. Kolb A, Hegyi A, Siddell S. Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N. J Gen Virol. 1997;78 ( Pt 11):2795-802 pubmed
    b>Aminopeptidase N (APN) is the major cell surface receptor for group 1 coronaviruses...
  67. Cowburn A, Sobolewski A, Reed B, Deighton J, Murray J, Cadwallader K, et al. Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils. J Biol Chem. 2006;281:12458-67 pubmed
    ..effect of TNFalpha in neutrophils isolated from healthy donors, and we show that inhibition of cell surface aminopeptidase N (APN) using actinonin, bestatin, or inhibitory peptides significantly enhanced the efficacy of TNFalpha-..
  68. Ito S, Miyahara R, Takahashi R, Nagai S, Takenaka K, Wada H, et al. Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancer. Gen Thorac Cardiovasc Surg. 2009;57:591-8 pubmed publisher
    Aminopeptidase-N (APN) is a membranebound protein that acts as a zinc-binding protease and participates in extracellular proteolysis...
  69. Yamada T, Abei M, Danjoh I, Shirota R, Yamashita T, Hyodo I, et al. Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib. BMC Cancer. 2015;15:260 pubmed publisher
    ..tested HCC cell lines (HuH-7, Li-7, PLC/PRF/5, HLF, HLE) before and after 2 months culture for several markers (CD13, EpCAM, CD133, CD44, CD90, CD24, CD166). Tumorigenicity was tested using nude mice...
  70. Chanduri M, Rai A, Malla A, Wu M, Fiedler D, Mallik R, et al. Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport. Biochem J. 2016;473:3031-47 pubmed publisher
    ..target for pyrophosphorylation by IP7, and this modification promotes the interaction of the IC N-terminus with the p150(Glued) subunit of dynactin...
  71. Lee J, Oh E, Han Y, Kim H, Park H, Kim C. Mesoporous Silica Nanocarriers with Cyclic Peptide Gatekeeper: Specific Targeting of Aminopeptidase?N and Triggered Drug Release by Stimuli-Responsive Conformational Transformation. Chemistry. 2017;: pubmed publisher
    ..on the surface of mesoporous nanocarrier is prepared not only for active targeting of the aminopeptidase?N (APN) expressed on cancer cells but also stimuli-responsive intracellular drug release triggered by a glutathione (GSH)-..
  72. Yeager C, Ashmun R, Williams R, Cardellichio C, Shapiro L, Look A, et al. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature. 1992;357:420-2 pubmed
    ..Here we report that human aminopeptidase N, a cell-surface metalloprotease on intestinal, lung and kidney epithelial cells, is a receptor for human ..
  73. Sørensen K, Abildgaard M, Haldrup C, Ulhøi B, Kristensen H, Strand S, et al. Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer. Br J Cancer. 2013;108:420-8 pubmed publisher
    ..This study investigates the expression, epigenetic regulation, and prognostic potential of ANPEP in PC. Aminopeptidase N (APN; encoded by ANPEP) expression was analysed by immunohistochemistry using tissue microarrays representing ..
  74. Aoki M, Nabeshima K, Hayashi H, Hamasaki M, Iwasaki H. Identification of APN/CD13 as the target antigen of FU3, a human monoclonal antibody that recognizes malignant fibrous histiocytoma. Int J Oncol. 2013;43:57-62 pubmed publisher
    ..In this study, we demonstrated that the antigen recognized by FU3 was identical to aminopeptidase N (APN/CD13) using FU3 immunoaffinity chromatography and N-terminal amino acid sequencing...
  75. Chen X, Yuan Y, Wang Q, Xie F, Xia D, Wang X, et al. Post-Translational Modification of Adiponectin Affects Lipid Accumulation, Proliferation and Migration of Vascular Smooth Muscle Cells. Cell Physiol Biochem. 2017;43:172-181 pubmed publisher
    Adiponectin (Apn) is a multifunctional adipokine that circulates as several oligomeric complexes in the blood stream...
  76. Khatun A, Rahman M, Ryu D, Kwon W, Pang M. Elevated aminopeptidase N affects sperm motility and early embryo development. PLoS ONE. 2017;12:e0184294 pubmed publisher
    b>Aminopeptidase N (APN) is a naturally occurring ectopeptidase present in mammalian semen. Previous studies have demonstrated that APN adversely affects male fertility through the alteration of sperm motility. This enzyme constitutes 0...
  77. Martínez de Castro D, García Gómez B, Gomez I, Bravo A, Soberon M. Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda. Peptides. 2017;98:99-105 pubmed publisher
    ..classes of aminopeptidase (N1, N3, N4 y N5) and actin, with the highest amino acid sequence coverage acquired for APN 1 and APN4...
  78. Si Ma L, Zhang J, Wang B, Zhang Y. Energy-efficient multidimensional Hellinger modulation for SPAD-based optical wireless communications. Opt Express. 2017;25:22178-22190 pubmed publisher
    ..For such system, the channel noise is additive Poisson noise (APN) rather than the commonly encountered additive white Gaussian noise (AWGN) and the corresponding maximum likelihood ..
  79. Wang G, Song G, Wang L, Gao F, Guo N, Zhang Y, et al. Analysis of the correlation between adiponectin gene polymorphism and metabolic syndrome incidence and its relationship with the degree of atherosclerosis in patients. Exp Ther Med. 2017;14:5002-5006 pubmed publisher
    The aim of the present study was to determine the correlation between adiponectin (APN) gene polymorphism, metabolic syndrome incidence, and degree of atherosclerosis in patients with this disease...
  80. Schmidt L, Stucke Ring J, Brand C, Schliemann C, Harrach S, Muley T, et al. CD13 as target for tissue factor induced tumor vascular infarction in small cell lung cancer. Lung Cancer. 2017;113:121-127 pubmed publisher
    Zinc-binding protease aminopeptidase N (CD13) is expressed on tumor vascular cells and tumor cells. It represents a potential candidate for molecular targeted therapy, e.g...
  81. Bergström P, Lindh V. Developing the role of Swedish advanced practice nurse (APN) through a blended learning master's program: Consequences of knowledge organisation. Nurse Educ Pract. 2018;28:196-201 pubmed publisher
    ..This article concludes by recommending that attention should be paid to developing APN role models in the current Swedish healthcare system.
  82. Watanabe Y, Iwaki Egawa S, Mizukoshi H, Fujimoto Y. Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N. Biol Chem Hoppe Seyler. 1995;376:397-400 pubmed
    ..In this study we compared the enzyme with membrane-bound aminopeptidase N purified from human placenta...
  83. Seli E, Senturk L, Bahtiyar O, Kayisli U, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertil Steril. 2001;75:1172-6 pubmed
    To determine whether aminopeptidase N (APN) regulates the cycle-dependent bioavailability of interleukin-8 (IL-8) in the endometrium. Prospective study. University medical center...
  84. Wentworth D, Tresnan D, Turner B, Lerman I, Bullis B, Hemmila E, et al. Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo. Virology. 2005;335:185-97 pubmed
    b>Aminopeptidase N, or CD13, is a receptor for serologically related coronaviruses of humans, pigs, and cats...
  85. Kato M, Azuma H, Akaike M, Iuchi T, Aihara K, Ikeda Y, et al. Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression. Atherosclerosis. 2005;183:49-55 pubmed
    ..we found in human umbilical vein endothelial cells (HUVECs) that aspirin up-regulates the expression of aminopeptidase N (APN/CD13) mRNA and its surface protein levels in a dose-dependent manner...
  86. Mahoney K, Petrovic N, Schacke W, Shapiro L. CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element. Gene. 2007;403:178-87 pubmed
    Angiogenic growth factors induce the transcription of the cell surface peptidase CD13/APN in activated endothelial cells of the tumor vasculature...
  87. Portugal L, Muñóz Garay C, Martínez de Castro D, Soberon M, Bravo A. Toxicity of Cry1A toxins from Bacillus thuringiensis to CF1 cells does not involve activation of adenylate cyclase/PKA signaling pathway. Insect Biochem Mol Biol. 2017;80:21-31 pubmed publisher
    ..pores in the membrane of the larval midgut cells after interaction with different receptors such as cadherin, aminopeptidase N and alkaline phosphatase and that this pore formation activity is responsible for the toxicity of these ..
  88. Schneider C, Bayerl M, Boyer C, Desai R, Claxton D, Van de Louw A. Increased CD13 Expression in Acute Myeloid Leukemia-associated Early Acute Hypoxic Respiratory Failure. Am J Respir Crit Care Med. 2017;196:1077-1080 pubmed publisher
  89. Chase A, Laudermilch E, Wang J, Shigematsu H, Yokoyama T, Schlieker C. Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1. Mol Biol Cell. 2017;28:2765-2772 pubmed publisher
    TorsinA is an essential AAA+ ATPase requiring LAP1 or LULL1 as cofactors. The dynamics of the Torsin/cofactor system remain poorly understood, with previous models invoking Torsin/cofactor assemblies with fixed stoichiometries...
  90. Kumar D, Seshadri K, Pandurangi M. Effect of Metformin-sustained Release Therapy on Low-density Lipoprotein Size and Adiponectin in the South Indian Women with Polycystic Ovary Syndrome. Indian J Endocrinol Metab. 2017;21:679-683 pubmed publisher
    The aim of the study is to compare surrogate markers of cardiovascular disease (CVD) risk, such as adiponectin (APN) levels and low-density lipoprotein (LDL) size, before and after sustained release metformin (Met-SR) therapy in women ..
  91. Luo L, Zheng W, Lian G, Chen H, Li L, Xu C, et al. Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway. Int J Mol Med. 2018;41:51-60 pubmed publisher
    The present study aimed to assess the effects of therapy with adiponectin (APN) gene-modified adipose-derived stem cells (ADSCs) on pulmonary arterial hypertension (PAH) in rats and the underlying cellular and molecular mechanisms...
  92. Guo R, Han M, Song J, Liu J, Sun Y. Adiponectin and its receptors are involved in hypertensive vascular injury. Mol Med Rep. 2017;: pubmed publisher
    Adipocyte-derived adiponectin (APN) is involved in the protection against cardiovascular disease, but the endogenous APN and its receptor expression in the perivascular adipocytes and their role in hypertensive vascular injury remain ..