CD11b

Summary

Gene Symbol: CD11b
Description: integrin subunit alpha M
Alias: CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, antigen CD11b (p170), cell surface glycoprotein MAC-1 subunit alpha, complement component 3 receptor 3 subunit, integrin, alpha M (complement component 3 receptor 3 subunit), leukocyte adhesion receptor MO1, macrophage antigen alpha polypeptide, neutrophil adherence receptor alpha-M subunit
Species: human
Products:     CD11b

Top Publications

  1. Coustet B, Agarwal S, Gourh P, Guedj M, Mayes M, Dieude P, et al. Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts. J Rheumatol. 2011;38:1033-8 pubmed publisher
  2. Lee J, Rieu P, Arnaout M, Liddington R. Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell. 1995;80:631-8 pubmed
    ..Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs. ..
  3. Ugarova T, Solovjov D, Zhang L, Loukinov D, Yee V, Medved L, et al. Identification of a novel recognition sequence for integrin alphaM beta2 within the gamma-chain of fibrinogen. J Biol Chem. 1998;273:22519-27 pubmed
    The interaction of leukocyte integrin alphaMbeta2 (CD11b/CD18, Mac-1) with fibrinogen has been implicated in the inflammatory response by contributing to leukocyte adhesion to the endothelium and subsequent transmigration...
  4. Li Y, Zhang L. The fourth blade within the beta-propeller is involved specifically in C3bi recognition by integrin alpha M beta 2. J Biol Chem. 2003;278:34395-402 pubmed
    Interactions between the complement degradation product C3bi and leukocyte integrin alpha M beta 2 are critical to phagocytosis of opsonized particles in host defense against foreign pathogens and certain malignant cells...
  5. van Gisbergen K, Ludwig I, Geijtenbeek T, van Kooyk Y. Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils. FEBS Lett. 2005;579:6159-68 pubmed
    ..This indicates that glycosylation-driven binding of both Mac-1 and CEACAM1 to DC-SIGN is essential for interactions of neutrophils with DCs and enables neutrophils to modulate T cell responses through interactions with DCs. ..
  6. Montecucco F, Steffens S, Burger F, Da Costa A, Bianchi G, Bertolotto M, et al. Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways. Cell Signal. 2008;20:557-68 pubmed publisher
    ..TNF-alpha-induced migration was a consequence of the TNF-alpha-induced up-regulation of integrin CD11b/CD18 (Mac-1) on neutrophil surface...
  7. Graham R, Cotsapas C, Davies L, Hackett R, Lessard C, Leon J, et al. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet. 2008;40:1059-61 pubmed publisher
    ..These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA. ..
  8. Simon D, Chen Z, Xu H, Li C, Dong J, McIntire L, et al. Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). J Exp Med. 2000;192:193-204 pubmed
    ..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis. ..
  9. Le Cabec V, Carreno S, Moisand A, Bordier C, Maridonneau Parini I. Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively. J Immunol. 2002;169:2003-9 pubmed
    ..Therefore, CR3 mediates type I phagocytosis under nonopsonic conditions and type II under opsonic conditions. This is the first evidence that a single receptor can mediate both types of phagocytosis depending on the ligand used. ..

More Information

Publications101 found, 100 shown here

  1. Lim J, Wiedemann A, Tzircotis G, Monkley S, Critchley D, Caron E. An essential role for talin during alpha(M)beta(2)-mediated phagocytosis. Mol Biol Cell. 2007;18:976-85 pubmed
    ..Remarkably, talin knockdown specifically abrogates uptake through complement receptor 3 (CR3, CD11b/CD18, alpha(M)beta(2) integrin) and not through the Fc gamma receptor...
  2. Hom G, Graham R, Modrek B, Taylor K, Ortmann W, Garnier S, et al. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. N Engl J Med. 2008;358:900-9 pubmed publisher
    ..In addition, variants on chromosome 16p11.22, near the genes encoding integrin alpha M (ITGAM, or CD11b) and integrin alpha X (ITGAX), were associated with SLE in the combined sample (rs11574637; ..
  3. Yang W, Zhao M, Hirankarn N, Lau C, Mok C, Chan T, et al. ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai. Hum Mol Genet. 2009;18:2063-70 pubmed publisher
    ..Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE...
  4. Harley J, Alarcon Riquelme M, Criswell L, Jacob C, Kimberly R, Moser K, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40:204-10 pubmed publisher
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE. ..
  5. Fung E, Smyth D, Howson J, Cooper J, Walker N, Stevens H, et al. Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes Immun. 2009;10:188-91 pubmed publisher
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus. ..
  6. Han S, Kim Howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge J, et al. Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). Hum Mol Genet. 2009;18:1171-80 pubmed publisher
  7. Macpherson M, Lek H, Prescott A, Fagerholm S. A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis. J Biol Chem. 2011;286:17303-10 pubmed publisher
    ..In addition, U937 cells expressing R77H-CD11b display increased IL-6 production as compared with WT-CD11b-expressing cells...
  8. Anaya J, Kim Howard X, Prahalad S, Cherñavsky A, Cañas C, Rojas Villarraga A, et al. Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases. Autoimmun Rev. 2012;11:276-80 pubmed publisher
    ..Thus ITGAM may not be a general autoimmunity gene but this variant may be specifically associated with SLE and systemic sclerosis. ..
  9. Michishita M, Videm V, Arnaout M. A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell. 1993;72:857-67 pubmed
    A recombinant peptide encoding the CD11b A domain bound 54Mn2+ with a high affinity. Other divalent cations, including Mg2+, Zn2+, Ni2+, Co2+, and Cd2+, but not Ca2+ or Ba2+, competed effectively for Mn2+ binding...
  10. Zhang L, Plow E. Identification and reconstruction of the binding site within alphaMbeta2 for a specific and high affinity ligand, NIF. J Biol Chem. 1997;272:17558-64 pubmed
    Engagement of the alphaMbeta2 (CD11b/CD18, Mac-1) integrin on neutrophils supports adhesion and induces various cellular responses. These responses can be blocked by a specific ligand of alphaMbeta2, neutrophil inhibitory factor (NIF)...
  11. Sachs U, Chavakis T, Fung L, Lohrenz A, Bux J, Reil A, et al. Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesion. Blood. 2004;104:727-34 pubmed
    The CD11b/CD18 integrin plays a crucial role in cell-cell adhesion processes...
  12. Nath S, Han S, Kim Howard X, Kelly J, Viswanathan P, Gilkeson G, et al. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet. 2008;40:152-4 pubmed publisher
    We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1...
  13. Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson P, et al. The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function. Blood. 2006;108:947-55 pubmed
    ..Overall, our data suggest that under steady-state conditions, signaling via CRs predominates to render DCs tolerogenic. ..
  14. Lim J, Dupuy A, Critchley D, Caron E. Rap1 controls activation of the ?(M)?(2) integrin in a talin-dependent manner. J Cell Biochem. 2010;111:999-1009 pubmed publisher
    ..These results show that Rap1-mediated activation of ?(M)?(2) in macrophages shares both common and distinct features from Rap1 activation of ?(IIb)?(3) expressed in CHO cells. ..
  15. Georgakopoulos T, Moss S, Kanagasundaram V. Integrin CD11c contributes to monocyte adhesion with CD11b in a differential manner and requires Src family kinase activity. Mol Immunol. 2008;45:3671-81 pubmed publisher
    Integrin-mediated adhesion of human monocytes to fibrinogen regulated by CD11b/CD18 and the closely related integrin CD11c/CD18, play a key role in inflammation...
  16. Kim Howard X, Maiti A, Anaya J, Bruner G, Brown E, Merrill J, et al. ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry. Ann Rheum Dis. 2010;69:1329-32 pubmed publisher
    ..0% (SLE), 20.4% (renal), 18.1% (immunological) and 19.5% (discoid). These results show a strong association between the risk allele (A) at rs1143679 and renal disease, discoid rash and immunological manifestations of SLE. ..
  17. Lee J, Bankston L, Arnaout M, Liddington R. Two conformations of the integrin A-domain (I-domain): a pathway for activation?. Structure. 1995;3:1333-40 pubmed
    ..We propose that the Mg2+ form represents the conformation of the domain in the active state and the Mn2+ form the conformation in the inactive state of the integrin. ..
  18. Mahalingam B, Ajroud K, Alonso J, Anand S, Adair B, Horenstein A, et al. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol. 2011;187:6393-401 pubmed publisher
    ..As with other ligand-mimetic integrin antagonists, the function-blocking mAb 107 binds MIDAS of integrin CD11b/CD18 A domain (CD11bA), but in contrast, it favors the inhibitory Ca(2+) ion over the Mg(2+) ion at MIDAS...
  19. Kulkarni M, Bowman E, Gabriel J, Amburgy T, Mayne E, Zidar D, et al. Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection. Open Forum Infect Dis. 2016;3:ofw224 pubmed publisher
    ..05 for all). Increased proportions of CD16+ monocytes, cells with altered adhesion molecule expression, combined with elevated levels of their ligands, may promote vascular inflammation in HIV infection. ..
  20. Koutsogiannaki S, Schaefers M, Okuno T, Ohba M, Yokomizo T, Priebe G, et al. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci. 2017;156:402-411 pubmed publisher
    ..In conclusion, prolonged isoflurane exposure worsened the outcome of experimental polymicrobial abdominal sepsis and was associated with impaired neutrophil recruitment and bacterial phagocytosis via reduced LFA-1 and Mac-1 function...
  21. Lee W, Moon M, Kim H, Lee T, Oh M. Heat stress-induced memory impairment is associated with neuroinflammation in mice. J Neuroinflammation. 2015;12:102 pubmed publisher
  22. Wang Y, Liu D, Zhang H, Wang Y, Wei L, Liu Y, et al. Ultrafine carbon particles promote rotenone-induced dopamine neuronal loss through activating microglial NADPH oxidase. Toxicol Appl Pharmacol. 2017;322:51-59 pubmed publisher
    ..Our findings delineated the potential role of ultrafine particles alone and in combination with pesticide rotenone in the pathogenesis of PD. ..
  23. Healy L, Puy C, Fernandez J, Mitrugno A, Keshari R, Taku N, et al. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017;292:8616-8629 pubmed publisher
  24. Sendide K, Reiner N, Lee J, Bourgoin S, Talal A, Hmama Z. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1. J Immunol. 2005;174:4210-9 pubmed
    ..This converts low avidity CR3 into an active receptor leading to increased bacterial internalization. ..
  25. Karyampudi L, Lamichhane P, Krempski J, Kalli K, Behrens M, Vargas D, et al. PD-1 Blunts the Function of Ovarian Tumor-Infiltrating Dendritic Cells by Inactivating NF-κB. Cancer Res. 2016;76:239-50 pubmed publisher
    ..PD-1 expression was recently found to be upregulated on tumor-infiltrating murine (CD11c(+)CD11b(+)CD8(-)CD209a(+)) and human (CD1c(+)CD19(-)) myeloid dendritic cells (TIDC), an innate immune cell type also ..
  26. Wald T, Osickova A, Masin J, Liskova P, Petry Podgorska I, Matousek T, et al. Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin. Pathog Dis. 2016;74: pubmed publisher
    ..cough agent Bordetella pertussis penetrates phagocytes expressing the integrin complement receptor 3 (CR3, CD11b/CD18, α(M)β(2) or Mac-1)...
  27. Valentin A, Lundin K, Patarroyo M, Asjo B. The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells. J Immunol. 1990;144:934-7 pubmed
    ..They also suggest that intercellular adhesion contributes to virus transmission from cell to cell and may be an important mechanism for virus spreading. ..
  28. Nagaoka K, Matoba T, Mao Y, Nakano Y, Ikeda G, Egusa S, et al. A New Therapeutic Modality for Acute Myocardial Infarction: Nanoparticle-Mediated Delivery of Pitavastatin Induces Cardioprotection from Ischemia-Reperfusion Injury via Activation of PI3K/Akt Pathway and Anti-Inflammation in a Rat Model. PLoS ONE. 2015;10:e0132451 pubmed publisher
    ..nanoparticle incorporating FITC accumulated in the IR myocardium through enhanced vascular permeability, and in CD11b-positive leukocytes in the IR myocardium and peripheral blood after intravenous treatment...
  29. Sarkar S, Malovic E, Plante B, Zenitsky G, Jin H, Anantharam V, et al. Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility. J Vis Exp. 2017;: pubmed publisher
    ..Herein, we demonstrate a refinement of the column-free CD11b magnetic separation method that achieves a high cell recovery and enhanced purity in half the amount of time...
  30. Wong K, Noubade R, Manzanillo P, Ota N, Foreman O, Hackney J, et al. Mice deficient in NRROS show abnormal microglial development and neurological disorders. Nat Immunol. 2017;18:633-641 pubmed publisher
    ..Nrros-/- mice display astrogliosis and lack normal CD11bhiCD45lo microglia, but they show no detectable demyelination or neuronal loss...
  31. Yamanishi K, Mukai K, Hashimoto T, Ikubo K, Nakasho K, El Darawish Y, et al. Physiological and molecular effects of interleukin-18 administration on the mouse kidney. J Transl Med. 2018;16:51 pubmed publisher
    ..Short- and long-term administration of interleukin-18 appeared to have no adverse effects on the kidney in these mice, suggesting that administration may be a safe and novel treatment for metabolic diseases and cancer. ..
  32. Pluskota E, Soloviev D, Szpak D, Weber C, Plow E. Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2. J Immunol. 2008;181:3609-19 pubmed
    ..Hence, engagement of a single integrin by closely related ligands can induce distinct signaling pathways, which can elicit distinct cellular responses. ..
  33. Mostacada K, Oliveira F, Villa Verde D, Martinez A. Lack of galectin-3 improves the functional outcome and tissue sparing by modulating inflammatory response after a compressive spinal cord injury. Exp Neurol. 2015;271:390-400 pubmed publisher
    ..At this same time point, no differences in the percentage of the CD11b/Arginase1 positive cells were observed...
  34. Chen Q, Li Y, Wang X, Su Y, Cui S, Miao M, et al. Evaluating antithrombotic activity of HY023016 on rat hypercoagulable model. Eur J Pharmacol. 2016;781:190-7 pubmed publisher
    ..HY023016 was able to inhibit thrombin- or ADP-induced platelet P-selectin or CD40L expression, leukocyte CD11b expression and formation of platelet-leukocyte aggregates in dose-dependent manner...
  35. Ren J, Zhao J, Dai J, Griffin J, Wang L, Wu X, et al. Hepatitis C virus-induced myeloid-derived suppressor cells regulate T-cell differentiation and function via the signal transducer and activator of transcription 3 pathway. Immunology. 2016;148:377-86 pubmed publisher
    ..expansion of myeloid-derived suppressor cells (MDSCs), in particular the monocytic MDSCs (M-MDSCs; CD14(+) CD33(+) CD11b(+) HLA-DR(-/low) ), in patients with chronic hepatitis C virus (HCV) infection...
  36. Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, et al. Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol. 2016;56:24-41 pubmed publisher
    ..reveals that the loss of laminin α5 resulted in increased numbers of CD45+, CD4+ and CD11b+ immune cells in the skin, which temporo-spatial analyses revealed were detectable only subsequent to ..
  37. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, et al. IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. J Exp Med. 2017;214:1607-1618 pubmed publisher
    ..In this study, we show that IL-22BP is highly expressed by CD11b+CD8?- dendritic cells in the subepithelial dome region of Peyer's patches (PPs)...
  38. Huang X, Rao A, Zhou W, Aslanian R, Nargund R, Buevich A, et al. The synthesis of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as potent CRTh2 antagonists. Bioorg Med Chem Lett. 2017;27:5344-5348 pubmed publisher
    ..These synthetic strategies have helped to accelerate the SAR development of this series, and potent lead compounds were identified in both the CRTh2 receptor binding assay and the CD11b biomarker assay.
  39. Zhu Y, Peng K, Meng X, Ji F. Attenuation of neuroinflammation by dexmedetomidine is associated with activation of a cholinergic anti-inflammatory pathway in a rat tibial fracture model. Brain Res. 2016;1644:1-8 pubmed publisher
    ..Overexpression of microglial (CD11b) and astrocytic (GFAP) responses to injury were observed in the hippocampus...
  40. Klar A, Biedermann T, Simmen Meuli C, Reichmann E, Meuli M. Comparison of in vivo immune responses following transplantation of vascularized and non-vascularized human dermo-epidermal skin substitutes. Pediatr Surg Int. 2017;33:377-382 pubmed publisher
    ..The expression of distinct inflammatory cell markers specific for host-derived monocytes/macrophages (CD11b, CD68) or granulocytes (HIS48) was analyzed by immunofluorescence microscopy...
  41. Martínez Méndez D, Rivera Toledo E, Ortega E, Licona Limón I, Huerta L. Monocyte-lymphocyte fusion induced by the HIV-1 envelope generates functional heterokaryons with an activated monocyte-like phenotype. Exp Cell Res. 2017;352:9-19 pubmed publisher
    ..showed morphological changes compatible with maturation, and high expression of the differentiation marker CD11b in the absence of differentiation-inducing agents...
  42. Wang R, Xu B, Xu H. Up-Regulation of TGF-? Promotes Tendon-to-Bone Healing after Anterior Cruciate Ligament Reconstruction using Bone Marrow-Derived Mesenchymal Stem Cells through the TGF-?/MAPK Signaling Pathway in a New Zealand White Rabbit Model. Cell Physiol Biochem. 2017;41:213-226 pubmed publisher
    ..CD90 and CD44 were positively expressed, while CD11b was not detected...
  43. Poncini C, Gonzalez Cappa S. Dual role of monocyte-derived dendritic cells in Trypanosoma cruzi infection. Eur J Immunol. 2017;47:1936-1948 pubmed publisher
    ..Over time, this population became enriched in CD11b+ Ly6C+ CD11c+ MHCII+ CD86+ cells resembling inflammatory ..
  44. Ito K, Hamamichi S, Abe T, Akagi T, Shirota H, Kawano S, et al. Antitumor effects of eribulin depend on modulation of the tumor microenvironment by vascular remodeling in mouse models. Cancer Sci. 2017;108:2273-2280 pubmed publisher
    ..Furthermore, infiltrating CD11b-positive immune cells were significantly increased in multiple eribulin-treated xenografted tumors, and natural ..
  45. Gürlevik E, Fleischmann Mundt B, Brooks J, Demir I, Steiger K, Ribback S, et al. Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells. Gastroenterology. 2016;151:338-350.e7 pubmed publisher
    ..Gemcitabine inhibited accumulation of CD11b+Gr1intF4/80int myeloid-derived suppressor cells at the resection margin and increased the number of natural killer ..
  46. Li S, Zhou B, Liu B, Zhou Y, Zhang H, Li T, et al. Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration. Mol Med Rep. 2016;14:5057-5064 pubmed publisher
    ..nicotine significantly attenuated the clinical and histopathological changes associated with arthritis, reduced CD11b?positive macrophages in the synovium, and downregulated the serum expression levels of MIP?1? and MCP?1...
  47. Jordan K, Kapoor P, Spongberg E, Tobin R, Gao D, Borges V, et al. Immunosuppressive myeloid-derived suppressor cells are increased in splenocytes from cancer patients. Cancer Immunol Immunother. 2017;66:503-513 pubmed publisher
    ..We found that total MDSCs (Linneg CD11bpos CD33pos HLA-DRneg), granulocytic MDSCs (additional markers CD14neg ..
  48. Dodd R, Lee C, Overton T, Huang W, Eward W, Luo L, et al. NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response. Cancer Res. 2017;77:4486-4497 pubmed publisher
    ..hematopoietic cells accelerated tumor onset and increased levels of tumor-infiltrating immune cells comprised of CD11b+ cells, monocytes, and mast cells...
  49. Szpak D, Izem L, Verbovetskiy D, Soloviev D, Yakubenko V, Pluskota E. ?M?2 Is Antiatherogenic in Female but Not Male Mice. J Immunol. 2018;200:2426-2438 pubmed publisher
    ..Because integrin ?M?2 (CD11b/CD18) mediates multiple diverse functions of leukocytes, we examined its role in atherogenesis...
  50. Liu Y, Sharma T, Chen I, Reichenberger E, Ueki Y, Arif Y, et al. Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling. Bone. 2018;111:28-35 pubmed publisher
    ..PAI1, a target gene of TGFβ signaling, was elevated 2-fold in cherubism CD11b-,CD45- cells compared to wild type cells, while the expression of BAMBI, an inhibitor of TGF..
  51. Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, et al. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep. 2016;6:23505 pubmed publisher
    ..In the gut, there exists a minor DC subset defined as CD103(+)CD11b(-) that also expresses the chemokine receptor XCR1...
  52. Lv B, Huo F, Zhu Z, Xu Z, Dang X, Chen T, et al. Crocin Upregulates CX3CR1 Expression by Suppressing NF-?B/YY1 Signaling and Inhibiting Lipopolysaccharide-Induced Microglial Activation. Neurochem Res. 2016;41:1949-57 pubmed publisher
    ..After crocin pretreatment, the expression of microglial markers (CD11b and Iba-1) and pro-inflammatory mediators (iNOS, COX-2, IL-1?, and TNF-?) induced by LPS were significantly ..
  53. Buri M, Dias C, Barbosa C, Nogueira Pedro A, Ribeiro Filho A, Miranda A, et al. Gomesin acts in the immune system and promotes myeloid differentiation and monocyte/macrophage activation in mouse. Peptides. 2016;85:41-45 pubmed publisher
    ..9ng/mL; Gomesin: 138.68±33.68ng/mL) and monocyte chemoattractant protein-1 (Control: 0.872±0.093ng/mL; Gomesin: 1.83±0.067ng/mL). Thus, this report showed immunomodulatory activity of gomesin in the immune system of mice. ..
  54. Kuttkat N, Mohs A, Ohl K, Hooiveld G, Longerich T, Tenbrock K, et al. Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease. Gut. 2017;66:908-919 pubmed publisher
    ..mice presented significantly decreased transaminase levels, concomitant with reduced numbers of CD11b+ dendritic cells and CD8+ T cells...
  55. Vasconcelos D, Gonçalves R, Almeida C, Pereira I, Oliveira M, Neves N, et al. Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration. Biomaterials. 2016;111:163-178 pubmed publisher
    ..namely increased T cells and decreased B, NK and NKT lymphocytes and myeloid cell, including the Mac-1+ (CD18+/CD11b+) subpopulation. At 8 weeks, Fg-3D led to decreased plasma levels of IL-1? and increased TGF-?1...
  56. Li Y, Golden J, Camhi M, Zhang X, Fritz Y, Diaconu D, et al. Protection from Psoriasis-Related Thrombosis after Inhibition of IL-23 or IL-17A. J Invest Dermatol. 2018;138:310-315 pubmed publisher
    ..This decrease in skin inflammation paralleled decreases in splenic neutrophils (CD11b+Ly6G+) but not monocytes (CD11b+Ly6Chigh) or T cells (CD4+)...
  57. Hong D, Ding J, Li O, He Q, Ke M, Zhu M, et al. Human-induced pluripotent stem cell-derived macrophages and their immunological function in response to tuberculosis infection. Stem Cell Res Ther. 2018;9:49 pubmed publisher
    ..iPS-Mφ express high levels of CD14, CD11b, CD40, CD68, and major histocompatibility complex II (MHC-II)...
  58. Mobberley Schuman P, Weiss A. Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils. Infect Immun. 2005;73:7317-23 pubmed
    CR3 (CD11b/CD18) is expressed on neutrophils, and the engagement of CR3 can promote phagocytosis...
  59. Bouhlal H, Chomont N, Requena M, Nasreddine N, Saidi H, Legoff J, et al. Opsonization of HIV with complement enhances infection of dendritic cells and viral transfer to CD4 T cells in a CR3 and DC-SIGN-dependent manner. J Immunol. 2007;178:1086-95 pubmed
    ..Thus, the virus uses complement to its advantage to facilitate early steps leading to infection following mucosal transmission of HIV. ..
  60. Mastej K, Adamiec R. Neutrophil surface expression of CD11b and CD62L in diabetic microangiopathy. Acta Diabetol. 2008;45:183-90 pubmed publisher
    The aims of the study are (1) assessment of cell surface expression of adhesion molecules CD11b and CD62L on peripheral blood neutrophils in patients with type 2 diabetes and microangiopathy; (2) analysis of serum levels of soluble ..
  61. Ørning P, Hoem K, Coron A, Skjåk Bræk G, Mollnes T, Brekke O, et al. Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation. J Control Release. 2016;229:58-69 pubmed publisher
    ..The leukocyte adhesion was abolished by inhibitory antibodies against CD18 and partly reduced by CD11b, but not by CD11c...
  62. Dong G, Si C, Zhang Q, Yan F, Li C, Zhang H, et al. Autophagy regulates accumulation and functional activity of granulocytic myeloid-derived suppressor cells via STAT3 signaling in endotoxin shock. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2796-2807 pubmed publisher
    ..Myeloid-derived suppressor cells (MDSCs) are derived from CD11b+Gr1+ cells under pathological conditions and play an immunosuppressive role in the ..
  63. Quach A, Ferrante A. The Application of Dextran Sedimentation as an Initial Step in Neutrophil Purification Promotes Their Stimulation, due to the Presence of Monocytes. J Immunol Res. 2017;2017:1254792 pubmed publisher
    ..centrifugation, we found that neutrophils from the 2-step method had a significant increase in cell surface CD11b expression and CD62L shedding and a marked increase in adhesion...
  64. Phipps Green A, Topless R, Merriman M, Dalbeth N, Gow P, Harrison A, et al. No evidence for association of the systemic lupus erythematosus-associated ITGAM variant, R77H, with rheumatoid arthritis in the Caucasian population. Rheumatology (Oxford). 2009;48:1614-5 pubmed publisher
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    ..had profound effects on the breast tumor microenvironment increasing the recruitment of F4/80+ and CD11b+ macrophages and increasing angiogenesis...
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    ..1-Ter119- CD11clow/-CD115-F4/80low/-Gr-1- CD11b+, but surprisingly express high levels of PD-L1...
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    ..period, the tumor was removed and the cells were identified by flow cytometry with labeling to CD4, CD8, CD11c, CD11b, CD80, CD86 and Ia, and intracelular staining IL-10, IL-12, TNF-?, IFN-?, IL-17, Tbet, GATA3, ROR?t and FoxP3...
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    ..We examined whether immediate TLR induced changes in CD11b and L-selectin (CD62L) expression are able to discriminate the presence and severity of atherosclerotic disease by ..
  70. Pyter L, Suarez Kelly L, Carson W, Kaur J, Bellisario J, Bever S. Novel rodent model of breast cancer survival with persistent anxiety-like behavior and inflammation. Behav Brain Res. 2017;330:108-117 pubmed publisher
    ..cytokines (IL-6, CXCL1, IL-10) and myeloid-derived cells and modulated neuroinflammatory gene expression (Cd11b, Cxcl1)...
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    ..from myeloid cells, and decreased T-cell proliferation via upregulation of Arg, iNOS, VEGF, IL6, and IL1b from CD11b+ cells...
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    ..This article is protected by copyright. All rights reserved...
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    ..The expression levels of glial fibrillary acidic protein (GFAP) and cluster of differentiation 11b (CD11b) in the hippocampus were determined with an immunohistochemistry assay...
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    ..These facts may represent an escape mechanism for the fungus by delaying cell death and allowing the fungus to survive inside leucocytes. ..
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    ..Altogether, our data demonstrate that inside-out signaling could modulate ligand binding directly by changing the ligand-binding pocket per se and/or indirectly by inducing multiple conformational changes within the receptor. ..
  76. Yang L, Liu Z, Ren H, Zhang L, Gao S, Ren L, et al. DR?1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury. Metab Brain Dis. 2017;32:1395-1402 pubmed publisher
    ..Conversely, DR?1-MOG-35-55 treatment of TBI increased numbers of circulating CD11b+ monocytes and their expression of CD74 but had no detectable effect on cell numbers or marker ..
  77. Nakamura K, Yaguchi T, Ohmura G, Kobayashi A, Kawamura N, Iwata T, et al. Involvement of local renin-angiotensin system in immunosuppression of tumor microenvironment. Cancer Sci. 2017;: pubmed publisher
    ..ARB administration did not change the numbers of CD11b+ myeloid cells in tumors, but significantly reduced their T-cell inhibitory ability along with ..
  78. Capo C, Moynault A, Collette Y, Olive D, Brown E, Raoult D, et al. Coxiella burnetii avoids macrophage phagocytosis by interfering with spatial distribution of complement receptor 3. J Immunol. 2003;170:4217-25 pubmed
    ..integrin and is restricted by impaired cross-talk of alpha(v)beta(3) integrin and complement receptor 3 (CR3) (CD11b/CD18). In this study, we showed that CR3 molecules remained outside the pseudopodal extensions induced by C...
  79. Mehra M, Kobashigawa J, Deng M, Fang K, Klingler T, Lal P, et al. Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts. J Heart Lung Transplant. 2007;26:1255-63 pubmed
    ..These data suggest that pathways regulating T-cell homeostasis and corticosteroid sensitivity are associated with future ACR in cardiac allografts and suggest that these signals are evident before histologically detectable rejection. ..
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    ..Together, these data demonstrate a direct role of LECs in the modulation of immune response and suggest a function of the lymphatic endothelium in preventing undesired immune reactions in inflammatory conditions...
  81. Dumont A, Yoong P, Day C, Alonzo F, McDonald W, Jennings M, et al. Staphylococcus aureus LukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1. Proc Natl Acad Sci U S A. 2013;110:10794-9 pubmed publisher
    ..Here we describe the identification of CD11b, the ? subunit of the ?M/?2 integrin (CD11b/CD18), macrophage-1 antigen, or complement receptor 3, as a cellular ..
  82. Dunsmore G, Bozorgmehr N, Delyea C, Koleva P, Namdar A, Elahi S. Erythroid Suppressor Cells Compromise Neonatal Immune Response against Bordetella pertussis. J Immunol. 2017;199:2081-2095 pubmed publisher
    ..by increased production of protective cytokines IFN-?, TNF-?, and IL-12, as well as recruitment of NK cells, CD11b+, and CD11c+ cells in the lung...
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    We report the unique role of CX3CL1 (or fractalkine) on CD11b+ myelomonocytic cells expressing CX3CR1, the only known receptor for CX3CL1, in promoting blood perfusion recovery...
  84. Kotovuori A, Pessa Morikawa T, Kotovuori P, Nortamo P, Gahmberg C. ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity. J Immunol. 1999;162:6613-20 pubmed
    ..have shown that a peptide derived from the first Ig domain of ICAM-2 (P1) binds to LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) and activates leukocyte aggregation...
  85. Brugnoli F, Lambertini E, Varin Blank N, Piva R, Marchisio M, Grassilli S, et al. Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation. Exp Cell Res. 2010;316:38-47 pubmed publisher
    ..it strengthens the drug effects and is involved in the regulation of maturation-related proteins, such as the CD11b surface antigen...
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    ..At 2 days, C1q protein was evident in the CA3 with elevated C1qa, C1qb, C3, Cr3a, and Cr3b mRNA levels...
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    ..TSPO was upregulated in Iba1+ or CD11b+CD45int cells from mice subjected to MCAO and reperfusion...
  88. Shimaoka M, Lu C, Salas A, Xiao T, Takagi J, Springer T. Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds. Proc Natl Acad Sci U S A. 2002;99:16737-41 pubmed
    ..By contrast, a disulfide stabilizing the closed conformation resulted in inactive alphaMbeta2 that was resistant to activation but became activatable after dithiothreitol treatment. ..
  89. McClure C, McPeak M, Youssef D, Yao Z, McCall C, El Gazzar M. Stat3 and C/EBP? synergize to induce miR-21 and miR-181b expression during sepsis. Immunol Cell Biol. 2017;95:42-55 pubmed publisher
    ..We reported that microRNA (miR) 21 and miR-181b expression in Gr1+CD11b+ myeloid progenitors increase septic MDSCs in mice by arresting macrophage and dendritic cell ..
  90. Alexeev V, Salas Alanis J, Palisson F, Mukhtarzada L, Fortuna G, Uitto J, et al. Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration. J Invest Dermatol. 2017;137:2298-2308 pubmed publisher
    ..skin with resting (CD45RA+) and activated (CD45RO+) T cells and CXCR2+ CD11b+ cells, many of which were identified as CD16b+ neutrophils...
  91. Vandooren J, Swinnen W, Ugarte Berzal E, Boon L, Dorst D, Martens E, et al. Endotoxemia shifts neutrophils with TIMP-free gelatinase B/MMP-9 from bone marrow to the periphery and induces systematic upregulation of TIMP-1. Haematologica. 2017;102:1671-1682 pubmed publisher
    ..MMP-9-containing cells towards peripheral organs, a pattern which was primarily associated with a relocation of CD11bhighGr-1high cells...
  92. Ferrini M, Carvalho S, Cho Y, Postma B, Miranda Marques L, Pinkerton K, et al. Prenatal tobacco smoke exposure predisposes offspring mice to exacerbated allergic airway inflammation associated with altered innate effector function. Part Fibre Toxicol. 2017;14:30 pubmed publisher
    ..Moreover, offspring from ETS-exposed dams exhibited a higher frequency of CD11b+ dendritic cells and CD3+CD4+ T lymphocytes in the lungs following allergen ..