CD105

Summary

Gene Symbol: CD105
Description: endoglin
Alias: END, HHT1, ORW1, endoglin, CD105 antigen
Species: human
Products:     CD105

Top Publications

  1. Clemente M, Nunez O, Lorente R, Rincon D, Matilla A, Salcedo M, et al. Increased intrahepatic and circulating levels of endoglin, a TGF-beta1 co-receptor, in patients with chronic hepatitis C virus infection: relationship to histological and serum markers of hepatic fibrosis. J Viral Hepat. 2006;13:625-32 pubmed
    b>Endoglin, a transforming growth factor (TGF)-beta1 co-receptor, has been associated with renal and cutaneous fibrosis, as overexpression of this protein has been observed in biopsies from patients with glomerulosclerosis and scleroderma, ..
  2. Barbara N, Wrana J, Letarte M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem. 1999;274:584-94 pubmed
    b>Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor (TGF)-beta1 and -beta3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by affinity labeling of endothelial and leukemic cells...
  3. Meng Q, Lux A, Holloschi A, Li J, Hughes J, Foerg T, et al. Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. J Biol Chem. 2006;281:37069-80 pubmed
    b>Endoglin is a membrane-inserted protein that is preferentially synthesized in angiogenic vascular endothelial and smooth muscle cells...
  4. Srinivas S, Morrison A, Andrela C, Elovitz M. Allelic variations in angiogenic pathway genes are associated with preeclampsia. Am J Obstet Gynecol. 2010;202:445.e1-11 pubmed publisher
    ..polymorphisms in 6 genes (vascular endothelial growth factor A, B, and C; fms-like tyrosine kinase 1 and 4; endoglin) were genotyped...
  5. Berg J, Porteous M, Reinhardt D, Gallione C, Holloway S, Umasunthar T, et al. Hereditary haemorrhagic telangiectasia: a questionnaire based study to delineate the different phenotypes caused by endoglin and ALK1 mutations. J Med Genet. 2003;40:585-90 pubmed
    ..Causative mutations for HHT have been identified in two genes, endoglin and ALK1, which encode proteins involved in serine-threonine kinase signalling in the endothelial cell...
  6. Gougos A, Letarte M. Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J Biol Chem. 1990;265:8361-4 pubmed
    b>Endoglin is a major glycoprotein of human vascular endothelium. As observed with monoclonal antibody 44G4, the distribution of endoglin is restricted to endothelial cells in all tissues except bone marrow...
  7. Craft C, Romero D, Vary C, Bergan R. Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1 pathway. Oncogene. 2007;26:7240-50 pubmed
    b>Endoglin is a transforming growth factor beta (TGFbeta) superfamily auxiliary receptor. We had previously shown that it suppressed prostate cancer (PCa) cell motility, and that its expression was lost during PCa progression...
  8. Meurer S, Tihaa L, Borkham Kamphorst E, Weiskirchen R. Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling. Cell Signal. 2011;23:683-99 pubmed publisher
    b>Endoglin is an accessory component of the TGF-?-binding receptor complex that differentially modulates TGF-? and BMP responses...
  9. Pece N, Vera S, Cymerman U, White R, Wrana J, Letarte M. Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative. J Clin Invest. 1997;100:2568-79 pubmed
    b>Endoglin (CD105), a component of the TGF-beta 1 receptor complex, is the target gene for the dominantly inherited vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1)...

More Information

Publications104 found, 100 shown here

  1. Bossler A, Richards J, George C, Godmilow L, Ganguly A. Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. Hum Mutat. 2006;27:667-75 pubmed
    ..However, when diagnosed early, the complications can usually be prevented. Mutations in two genes, Endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1 or ALK1) have been associated with HHT...
  2. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim Y, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006;12:642-9 pubmed
    ..We report a novel placenta-derived soluble TGF-beta coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls ..
  3. Sanz Rodriguez F, Guerrero Esteo M, Botella L, Banville D, Vary C, Bernabeu C. Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins. J Biol Chem. 2004;279:32858-68 pubmed
    b>Endoglin is a component of the transforming growth factor-beta receptor complex abundantly expressed at the surface of endothelial cells and plays an important role in cardiovascular development and vascular remodeling...
  4. Romero D, O Neill C, Terzic A, Contois L, Young K, Conley B, et al. Endoglin regulates cancer-stromal cell interactions in prostate tumors. Cancer Res. 2011;71:3482-93 pubmed publisher
    b>Endoglin is an accessory receptor for TGF-? that has been implicated in prostate cancer cell detachment, migration, and invasiveness...
  5. Lee N, Blobe G. The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells. J Biol Chem. 2007;282:21507-17 pubmed
    ..pathways is further regulated in endothelial cells by the endothelial specific TGF-beta superfamily co-receptor, endoglin. The importance of endoglin, ALK-1, and ALK-5 in endothelial biology is underscored by the embryonic lethal ..
  6. Pera J, Slowik A, Dziedzic T, Borratynska A, Rog T, Betlej M, et al. Endoglin gene insertion polymorphism not associated with aneurysmal subarachnoid hemorrhage. J Neurosurg. 2005;102:879-81 pubmed
    ..4 and 0.8%, respectively (p = 0.18). The authors failed to find an association between the intronic insertion polymorphism of the ENG gene and aneurysmal SAH in a Polish population. ..
  7. Shovlin C, Hughes J, Scott J, Seidman C, Seidman J. Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. Am J Hum Genet. 1997;61:68-79 pubmed
    ..Linkage studies in four of eight families indicated an endoglin (ENG) gene mutation...
  8. Minhajat R, Mori D, Yamasaki F, Sugita Y, Satoh T, Tokunaga O. Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers. Virchows Arch. 2006;448:127-34 pubmed
    ..The present study compares the expression of CD105 with that of other endothelial markers in all tissue layers during the development of colon cancer...
  9. Zhang L, Han Y, Han Y. [Serum soluble Endoglin, plasma endothelin-1 and coagulation function in early onset severe preeclampsia with organ dysfunction]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010;22:371-4 pubmed
    To investigate the expression levels of serum soluble Endoglin (sEng), plasma endothelin-1 (ET-1) and coagulation function in patients suffering from early onset severe preeclampsia with organ dysfunction, and to analyze the clinical ..
  10. Kim M, Kim S, Lee H, Lee K, Seo J, Lee J, et al. Clinical and genetic analyses of three Korean families with hereditary hemorrhagic telangiectasia. BMC Med Genet. 2011;12:130 pubmed publisher
    ..b>Endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1; ALK1), receptors for transforming growth factor-? (TGF-?) ..
  11. Ali B, Ben Rebeh I, John A, Akawi N, Milhem R, Al Shehhi N, et al. Endoplasmic reticulum quality control is involved in the mechanism of endoglin-mediated hereditary haemorrhagic telangiectasia. PLoS ONE. 2011;6:e26206 pubmed publisher
    ..In the majority of the cases reported, the condition is caused by mutations in either ACVRL1 or endoglin genes, which encode components of the TGF-beta signalling pathway...
  12. Li D, Sorensen L, Brooke B, Urness L, Davis E, Taylor D, et al. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534-7 pubmed
    b>Endoglin is a transforming growth factor-beta (TGF-beta) binding protein expressed on the surface of endothelial cells...
  13. Cymerman U, Vera S, Pece Barbara N, Bourdeau A, White R, Dunn J, et al. Identification of hereditary hemorrhagic telangiectasia type 1 in newborns by protein expression and mutation analysis of endoglin. Pediatr Res. 2000;47:24-35 pubmed
    ..b>Endoglin is the gene mutated in HHT1, which is associated with a higher prevalence of pulmonary arteriovenous ..
  14. Conley B, Koleva R, Smith J, Kacer D, Zhang D, Bernabeu C, et al. Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain. J Biol Chem. 2004;279:27440-9 pubmed
    Mutations in the human endoglin gene result in hereditary hemorrhagic telangiectasia type 1, a vascular disorder characterized by multisystemic vascular dysplasia, arteriovenous malformations, and focal dilatation of postcapillary venules...
  15. Dietmann A, Helbok R, Lackner P, Fischer M, Reindl M, Lell B, et al. Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis?. J Infect Dis. 2009;200:1842-8 pubmed publisher
    ..The soluble form of the auxiliary receptor endoglin (sEng) may play a role in malaria pathogenesis...
  16. Liu Y, Jovanovic B, Pins M, Lee C, Bergan R. Over expression of endoglin in human prostate cancer suppresses cell detachment, migration and invasion. Oncogene. 2002;21:8272-81 pubmed
    ..We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion...
  17. Sanchez Elsner T, Botella L, Velasco B, Langa C, Bernabeu C. Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem. 2002;277:43799-808 pubmed
    b>Endoglin is a transforming growth factor-beta (TGF-beta) co-receptor expressed mainly on endothelial cells and involved in cardiovascular development, angiogenesis, and vascular remodeling...
  18. O Connor J, Farach Carson M, Schneider C, Carson D. Coculture with prostate cancer cells alters endoglin expression and attenuates transforming growth factor-beta signaling in reactive bone marrow stromal cells. Mol Cancer Res. 2007;5:585-603 pubmed
    ..expression in bone marrow stromal cells cocultured with prostate cancer cells and found reduced expression of endoglin, a transmembrane glycoprotein that functions as an auxiliary coreceptor for members of the transforming growth ..
  19. Yamashita H, Ichijo H, Grimsby S, Moren A, ten Dijke P, Miyazono K. Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta. J Biol Chem. 1994;269:1995-2001 pubmed
    Human endoglin is a dimeric protein that binds transforming growth factor-beta (TGF-beta). A porcine cDNA clone for endoglin was obtained from a porcine uterus cDNA library...
  20. Fonsatti E, Altomonte M, Nicotra M, Natali P, Maio M. Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels. Oncogene. 2003;22:6557-63 pubmed
    Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy...
  21. Luft F. Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule. Nephrol Dial Transplant. 2006;21:3052-4 pubmed
  22. Van Le B, Franke D, Svergun D, Han T, Hwang H, Kim K. Structural and functional characterization of soluble endoglin receptor. Biochem Biophys Res Commun. 2009;383:386-91 pubmed publisher
    b>Endoglin, an accessory membrane receptor of transforming growth factor-beta (TGF-beta)1, modulates the cellular response to TGF-beta via its interaction with type I and II TGF-beta receptors...
  23. Lastres P, Letamendia A, Zhang H, Rius C, Almendro N, Raab U, et al. Endoglin modulates cellular responses to TGF-beta 1. J Cell Biol. 1996;133:1109-21 pubmed
    b>Endoglin is a homodimeric membrane glycoprotein which can bind the beta 1 and beta 3 isoforms of transforming growth factor-beta (TGF-beta). We reported previously that endoglin is upregulated during monocyte differentiation...
  24. Pece Barbara N, Cymerman U, Vera S, Marchuk D, Letarte M. Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1. Hum Mol Genet. 1999;8:2171-81 pubmed
    b>ENDOGLIN codes for a homodimeric membrane glycoprotein that interacts with receptors for members of the TGF-beta superfamily and is the gene mutated in the autosomal dominant vascular disorder hereditary hemorrhagic telangiectasia type 1 (..
  25. Torsney E, Charlton R, Parums D, Collis M, Arthur H. Inducible expression of human endoglin during inflammation and wound healing in vivo. Inflamm Res. 2002;51:464-70 pubmed
    Because angiogenesis and inflammation are intimately associated and endoglin is required for angiogenesis, we wished to determine whether it also plays a role in inflammation...
  26. Lee N, Ray B, How T, Blobe G. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. J Biol Chem. 2008;283:32527-33 pubmed publisher
    ..b>Endoglin is a co-receptor predominantly expressed in endothelial cells that participates in TGFbeta-mediated signaling ..
  27. Chaiworapongsa T, Romero R, Savasan Z, Kusanovic J, Ogge G, Soto E, et al. Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia. J Matern Fetal Neonatal Med. 2011;24:1187-207 pubmed publisher
    To determine whether maternal plasma concentrations of placental growth factor (PlGF), soluble endoglin (sEng), soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and -2 could identify patients at risk for developing ..
  28. Wikstrom P, Lissbrant I, Stattin P, Egevad L, Bergh A. Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer. Prostate. 2002;51:268-75 pubmed
    b>Endoglin, a receptor for some of the members of the transforming growth factor-beta (TGF-beta) family, is expressed on proliferating endothelial cells and has been suggested as a marker of ongoing angiogenesis...
  29. Sabba C, Pasculli G, Lenato G, Suppressa P, Lastella P, Memeo M, et al. Hereditary hemorrhagic telangiectasia: clinical features in ENG and ALK1 mutation carriers. J Thromb Haemost. 2007;5:1149-57 pubmed
    ..The identification of a mutated ENG (HHT1) or ALK-1 (HHT2) gene now enables a genotype-phenotype correlation...
  30. Lee S, Kim J, Jang S, Kim D, Do Y, Suh G, et al. Clinical features and mutations in the ENG, ACVRL1, and SMAD4 genes in Korean patients with hereditary hemorrhagic telangiectasia. J Korean Med Sci. 2009;24:69-76 pubmed publisher
    ..Although mutations in the endoglin (ENG) and activin A receptor type II-like 1 (ACVRL1) genes have been known to cause HHT for more than 10 yr, ..
  31. Perez Gomez E, Eleno N, Lopez Novoa J, Ramirez J, Velasco B, Letarte M, et al. Characterization of murine S-endoglin isoform and its effects on tumor development. Oncogene. 2005;24:4450-61 pubmed
    b>Endoglin is a transmembrane glycoprotein that acts as an auxiliary receptor for transforming growth factor-beta (TGF-beta) and modulates cellular responses to this pleiotropic cytokine...
  32. McDonald J, Damjanovich K, Millson A, Wooderchak W, Chibuk J, Stevenson D, et al. Molecular diagnosis in hereditary hemorrhagic telangiectasia: findings in a series tested simultaneously by sequencing and deletion/duplication analysis. Clin Genet. 2011;79:335-44 pubmed publisher
    ..consecutive cases in which sequencing and large deletion/duplication analysis were performed simultaneously for endoglin (ENG) and activin-like receptor kinase 1 (ACVRL1)...
  33. Damjanovich K, Langa C, Blanco F, McDonald J, Botella L, Bernabeu C, et al. 5'UTR mutations of ENG cause hereditary hemorrhagic telangiectasia. Orphanet J Rare Dis. 2011;6:85 pubmed publisher
    ..of the patients have a mutation in the coding region of the activin A receptor type II-like 1 (ACVRL1) or Endoglin (ENG) gene...
  34. Dakeishi M, Shioya T, Wada Y, Shindo T, Otaka K, Manabe M, et al. Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan. Hum Mutat. 2002;19:140-8 pubmed
    ..Linkage analysis in two large families revealed a weak yet suggestive linkage to the HHT1 locus (encoding endoglin; ENG)...
  35. Lesca G, Plauchu H, Coulet F, Lefebvre S, Plessis G, Odent S, et al. Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 2004;23:289-99 pubmed
    ..1231C>T (p.Arg411Trp), c.1232G>C (p.Arg411Pro), and c.1232G>A (p.Arg411Gln) were found in seven, two, and one patients, respectively. Haplotype analysis was in favor of both a founder effect and a mutation hot-spot. ..
  36. Kuehl H, Caselitz M, Hasenkamp S, Wagner S, El Harith E, Manns M, et al. Hepatic manifestation is associated with ALK1 in hereditary hemorrhagic telangiectasia: identification of five novel ALK1 and one novel ENG mutations. Hum Mutat. 2005;25:320 pubmed
    ..In this study, we have identified five novel ALK1 and one ENG disease-causing mutations. We conclude that hepatic manifestation in HHT patients is associated with mutations in the ALK1 gene, but rarely with ENG mutations. ..
  37. Lesca G, Burnichon N, Raux G, Tosi M, Pinson S, Marion M, et al. Distribution of ENG and ACVRL1 (ALK1) mutations in French HHT patients. Hum Mutat. 2006;27:598 pubmed
    ..Our results also emphasize the higher prevalence of large insertions/deletions in ENG and the predominance of ACVRL1 over ENG mutations. ..
  38. Mano Y, Kotani T, Shibata K, Matsumura H, Tsuda H, Sumigama S, et al. The loss of endoglin promotes the invasion of extravillous trophoblasts. Endocrinology. 2011;152:4386-94 pubmed publisher
    b>Endoglin is a coreceptor for TGF-?, which is expressed in syncytiotrophoblasts. The soluble form of endoglin (sEng) has been observed to increase in the serum of preeclamptic patients...
  39. Nolan Stevaux O, Zhong W, Culp S, Shaffer K, Hoover J, Wickramasinghe D, et al. Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies. PLoS ONE. 2012;7:e50920 pubmed publisher
    b>Endoglin (ENG), a co-receptor for several TGF?-family cytokines, is expressed in dividing endothelial cells alongside ALK1, the ACVRL1 gene product...
  40. Blanco F, Santibanez J, Guerrero Esteo M, Langa C, Vary C, Bernabeu C. Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J Cell Physiol. 2005;204:574-84 pubmed
    ..b>Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, and ..
  41. Abdalla S, Cymerman U, Rushlow D, Chen N, Stoeber G, Lemire E, et al. Novel mutations and polymorphisms in genes causing hereditary hemorrhagic telangiectasia. Hum Mutat. 2005;25:320-1 pubmed
    Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder caused by mutations in Endoglin (ENG) or activin receptor-like kinase-1 (ALK1, ACVRL1) genes...
  42. Koleva R, Conley B, Romero D, Riley K, Marto J, Lux A, et al. Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-beta receptors. J Biol Chem. 2006;281:25110-23 pubmed
    ..of the functional relationship between the transforming growth factor-beta (TGFbeta) receptor proteins endoglin and ALK1 is essential to the understanding of the human vascular disease, hereditary hemorrhagic telangiectasia...
  43. Powers R, Jeyabalan A, Clifton R, Van Dorsten P, Hauth J, Klebanoff M, et al. Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies. PLoS ONE. 2010;5:e13263 pubmed publisher
    Differences in circulating concentrations of antiangiogenic factors sFlt1 and soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede the onset of preeclampsia weeks to months in low-risk pregnant women...
  44. Ikemoto T, Hojo Y, Kondo H, Takahashi N, Hirose M, Nishimura Y, et al. Plasma endoglin as a marker to predict cardiovascular events in patients with chronic coronary artery diseases. Heart Vessels. 2012;27:344-51 pubmed publisher
    Recent clinical studies have revealed that the expression of endoglin, an accessory protein for the TGF-? receptor, is increased in patients with atherosclerotic diseases...
  45. Tian H, Mythreye K, Golzio C, Katsanis N, Blobe G. Endoglin mediates fibronectin/?5?1 integrin and TGF-? pathway crosstalk in endothelial cells. EMBO J. 2012;31:3885-900 pubmed publisher
    ..specifically increase TGF-?1- and BMP-9-induced Smad1/5/8 phosphorylation via the TGF-? superfamily receptors endoglin and activin-like kinase-1 (ALK1)...
  46. Cheifetz S, Bellon T, Calés C, Vera S, Bernabeu C, Massague J, et al. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem. 1992;267:19027-30 pubmed
    b>Endoglin, a dimeric membrane glycoprotein expressed at high levels on human vascular endothelial cells, shares regions of sequence identity with betaglycan, a major binding protein for transforming growth factor-beta (TGF-beta) that co-..
  47. Guerrero Esteo M, Sanchez Elsner T, Letamendia A, Bernabeu C. Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J Biol Chem. 2002;277:29197-209 pubmed
    b>Endoglin is an auxiliary component of the transforming growth factor-beta (TGF-beta) receptor system, able to associate with the signaling receptor types I (TbetaRI) and II (TbetaRII) in the presence of ligand and to modulate the cellular ..
  48. Toporsian M, Gros R, Kabir M, Vera S, Govindaraju K, Eidelman D, et al. A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ Res. 2005;96:684-92 pubmed
    ..Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular disorder associated with ENDOGLIN (ENG) haploinsufficiency and characterized by venous dilatations, focal loss of capillaries, and arteriovenous ..
  49. Lesca G, Olivieri C, Burnichon N, Pagella F, Carette M, Gilbert Dussardier B, et al. Genotype-phenotype correlations in hereditary hemorrhagic telangiectasia: data from the French-Italian HHT network. Genet Med. 2007;9:14-22 pubmed
    ..We studied the relationship between the phenotype and genotype in patients with a proven mutation in either ENG (HHT1) or ACVRL1 (HHT2). Clinical features and their age of onset were compared between HHT1 and HHT2...
  50. Olivieri C, Pagella F, Semino L, Lanzarini L, Valacca C, Pilotto A, et al. Analysis of ENG and ACVRL1 genes in 137 HHT Italian families identifies 76 different mutations (24 novel). Comparison with other European studies. J Hum Genet. 2007;52:820-9 pubmed
    ..These results were compared to other European national studies and data from Italy, France and Spain were consistent for an higher incidence of ACVRL1 mutations. ..
  51. Lim J, Kim S, Park S, Lee M, Yang J, Kim M, et al. Soluble endoglin and transforming growth factor-beta1 in women who subsequently developed preeclampsia. Prenat Diagn. 2009;29:471-6 pubmed publisher
    This study aimed to analyze the differences of soluble endoglin (sEng) and transforming growth factor-beta1 (TGF-beta1) according to preeclamptic complications and to investigate the correlation between these factors and the clinical ..
  52. Pardali E, van der Schaft D, Wiercinska E, Gorter A, Hogendoorn P, Griffioen A, et al. Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma. Oncogene. 2011;30:334-45 pubmed publisher
    ..We demonstrate here that the transforming growth factor (TGF)-? co-receptor endoglin, an endothelial cell marker, is expressed by tumor cells and its expression correlates with tumor cell plasticity ..
  53. Lakshman M, Huang X, Ananthanarayanan V, Jovanovic B, Liu Y, Craft C, et al. Endoglin suppresses human prostate cancer metastasis. Clin Exp Metastasis. 2011;28:39-53 pubmed publisher
    b>Endoglin is a transmembrane receptor that suppresses human prostate cancer (PCa) cell invasion. Small molecule therapeutics now being tested in humans can activate endoglin signaling...
  54. McAllister K, Grogg K, Johnson D, Gallione C, Baldwin M, Jackson C, et al. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet. 1994;8:345-51 pubmed
    ..Linkage for some families has been established to chromosome 9q33-q34. In the present study, endoglin, a transforming growth factor beta (TGF-beta) binding protein, was analysed as a candidate gene for the disorder ..
  55. Bellon T, Corbi A, Lastres P, Calés C, Cebrian M, Vera S, et al. Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur J Immunol. 1993;23:2340-5 pubmed
    b>Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor-beta (TGF-beta) and whose expression is up-regulated on myeloid cells upon differentiation to macrophages...
  56. David L, Mallet C, Mazerbourg S, Feige J, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953-61 pubmed
    ..Overexpression of endoglin increases the BMP9 response, whereas silencing of both BMPRII and ActRIIA expressions completely abolishes it...
  57. Moody J, Singbrant S, Karlsson G, Blank U, Aspling M, Flygare J, et al. Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development. Stem Cells. 2007;25:2809-19 pubmed
    b>Endoglin is a transforming growth factor-beta (TGF-beta) accessory receptor recently identified as being highly expressed on long-term repopulating hematopoietic stem cells (HSC)...
  58. Hertig A, Fort J, Lefevre G, Chabbert Buffet N, Uzan M, Rondeau E, et al. Soluble endoglin in preeclamptic patients with or without HELLP syndrome. Am J Obstet Gynecol. 2010;202:594.e1-4 pubmed publisher
    The pathogenesis of the HELLP (hemolysis, enzyme liver, low platelets) syndrome is unknown. Recently soluble endoglin (sEng) was identified as a cause of the appearance of schistocytes and liver pathology in an animal model of ..
  59. Pan C, Bloodworth J, Mythreye K, Lee N. Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferation. Biochem Biophys Res Commun. 2012;424:620-3 pubmed publisher
    b>Endoglin is an endothelial-specific transforming growth factor beta (TGF-?) co-receptor essential for angiogenesis and vascular remodeling...
  60. Rossi E, Sanz Rodriguez F, Eleno N, Düwell A, Blanco F, Langa C, et al. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood. 2013;121:403-15 pubmed publisher
    Human endoglin is an RGD-containing transmembrane glycoprotein identified in vascular endothelial cells...
  61. Gallione C, Klaus D, Yeh E, Stenzel T, Xue Y, Anthony K, et al. Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles. Hum Mutat. 1998;11:286-94 pubmed
    ..Two genes have been identified for HHT. Endoglin, a TGF-beta binding protein which maps to chromosome 9q3, is the gene for HHT1...
  62. Fonsatti E, Del Vecchio L, Altomonte M, Sigalotti L, Nicotra M, Coral S, et al. Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies. J Cell Physiol. 2001;188:1-7 pubmed
    b>Endoglin (CD105) is a cell membrane glycoprotein over-expressed on highly proliferating endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within benign and malignant tissues...
  63. Li C, Gardy R, Seon B, Duff S, Abdalla S, Renehan A, et al. Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis. Br J Cancer. 2003;88:1424-31 pubmed
    b>CD105 and its ligand transforming growth factor beta (TGFbeta) are modulators of angiogenesis, which drives tumour growth and metastasis. Tumour microvessel density (MVD) has proven to be an important determinant of prognosis...
  64. Dales J, Garcia S, Andrac L, Carpentier S, Ramuz O, Lavaut M, et al. Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcome. Int J Oncol. 2004;24:1197-204 pubmed
    ..CD105 (endoglin) has been reported as expressed by activated endothelial cells and consequently should better reflect ..
  65. Fernandez L A, Sanz Rodriguez F, Zarrabeitia R, Perez Molino A, Morales C, Restrepo C, et al. Mutation study of Spanish patients with hereditary hemorrhagic telangiectasia and expression analysis of Endoglin and ALK1. Hum Mutat. 2006;27:295 pubmed
    ..telangiectasia (HHT) is an autosomal dominant and age-dependent vascular disorder originated by mutations in Endoglin (ENG) or activin receptor-like kinase-1 (ALK1, ACVRL1) genes...
  66. Llorca O, Trujillo A, Blanco F, Bernabeu C. Structural model of human endoglin, a transmembrane receptor responsible for hereditary hemorrhagic telangiectasia. J Mol Biol. 2007;365:694-705 pubmed
    b>Endoglin is a type I membrane protein expressed as a disulphide-linked homodimer on human vascular endothelial cells whose haploinsufficiency is responsible for the dominant vascular dysplasia known as hereditary hemorrhagic ..
  67. Yu D, Zhuang L, Sun X, Chen J, Yao Y, Meng K, et al. Particular distribution and expression pattern of endoglin (CD105) in the liver of patients with hepatocellular carcinoma. BMC Cancer. 2007;7:122 pubmed
    b>Endoglin (CD105) has been considered a prognostic marker for hepatocellular carcinoma (HCC), and widely used as an appropriate targeting for antiangenesis therapy in some cancers...
  68. Gu Y, Lewis D, Wang Y. Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies. J Clin Endocrinol Metab. 2008;93:260-6 pubmed
    Increased production of antiangiogenic factors soluble endoglin (sEng) and soluble fms-like tyrosine kinase receptor-1 (sFlt-1) by the placenta contributes to the pathophysiology in preeclampsia (PE)...
  69. Richards Yutz J, Grant K, Chao E, Walther S, Ganguly A. Update on molecular diagnosis of hereditary hemorrhagic telangiectasia. Hum Genet. 2010;128:61-77 pubmed publisher
    ..Germline mutations in two genes, endoglin (ENG) and activin receptor like kinase 1 (ACVRL1), have been implicated in this disease...
  70. Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
    b>Endoglin (CD105), a transmembrane protein of the transforming growth factor ? superfamily, plays a crucial role in angiogenesis. Mutations in endoglin result in the vascular defect known as hereditary hemorrhagic telangiectasia (HHT1)...
  71. Dubinski W, Gabril M, Iakovlev V, Scorilas A, Youssef Y, Faragalla H, et al. Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis. Hum Pathol. 2012;43:1037-43 pubmed publisher
    ..Angiogenesis has proven to be a useful prognostic indicator in different malignancies. Endoglin (CD105) is a new marker of angiogenesis found to have prognostic utility in various tumors...
  72. Alt A, Miguel Romero L, Donderis J, Aristorena M, Blanco F, Round A, et al. Structural and functional insights into endoglin ligand recognition and binding. PLoS ONE. 2012;7:e29948 pubmed publisher
    b>Endoglin, a type I membrane glycoprotein expressed as a disulfide-linked homodimer on human vascular endothelial cells, is a component of the transforming growth factor (TGF)-? receptor complex and is implicated in a dominant vascular ..
  73. Rius C, Smith J, Almendro N, Langa C, Botella L, Marchuk D, et al. Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1. Blood. 1998;92:4677-90 pubmed
    b>Endoglin (CD105) is a cell surface component of the transforming growth factor-beta (TGF-beta) receptor complex highly expressed by endothelial cells...
  74. Ho J, Poon R, Sun C, Xue W, Fan S. Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver. World J Gastroenterol. 2005;11:176-81 pubmed
    The expression pattern of endoglin (CD105) in hepatocellular carcinoma (HCC) has not been reported so far...
  75. Wehner L, Folz B, Argyriou L, Twelkemeyer S, Teske U, Geisthoff U, et al. Mutation analysis in hereditary haemorrhagic telangiectasia in Germany reveals 11 novel ENG and 12 novel ACVRL1/ALK1 mutations. Clin Genet. 2006;69:239-45 pubmed
    ..Mutations in endoglin (ENG) and activin A receptor type II-like kinase 1 (ACVRL1 or ALK1) have been found in patients with HHT...
  76. Yao Y, Pan Y, Chen J, Sun X, Qiu Y, Ding Y. Endoglin (CD105) expression in angiogenesis of primary hepatocellular carcinomas: analysis using tissue microarrays and comparisons with CD34 and VEGF. Ann Clin Lab Sci. 2007;37:39-48 pubmed
    ..of tumor microvessel density (MVD) was assessed in 105 patients with HCC by immunohistochemical staining of CD105, CD34, and vascular endothelial growth factor (VEGF)...
  77. Romero R, Nien J, Espinoza J, Todem D, Fu W, Chung H, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a smal. J Matern Fetal Neonatal Med. 2008;21:9-23 pubmed publisher
    ..b>Endoglin is a protein that regulates the pro-angiogenic effects of transforming growth factor beta, and its soluble form ..
  78. Fontalba A, Fernandez L A, García Alegría E, Albiñana V, Garrido Martin E, Blanco F, et al. Mutation study of Spanish patients with hereditary hemorrhagic telangiectasia. BMC Med Genet. 2008;9:75 pubmed publisher
    ..HHT) is an autosomal dominant and age-dependent vascular disorder characterised mainly by mutations in the Endoglin (ENG) or activin receptor-like kinase-1 (ALK1, ACVRL1) genes...
  79. Lopez Novoa J, Bernabeu C. The physiological role of endoglin in the cardiovascular system. Am J Physiol Heart Circ Physiol. 2010;299:H959-74 pubmed publisher
    b>Endoglin (CD105) is an integral membrane glycoprotein that serves as a coreceptor for members of the transforming growth factor-? superfamily of proteins...
  80. Morris E, Chrobak I, Bujor A, Hant F, Mummery C, Ten Dijke P, et al. Endoglin promotes TGF-?/Smad1 signaling in scleroderma fibroblasts. J Cell Physiol. 2011;226:3340-8 pubmed publisher
    ..The goal of this study was to determine the role of endoglin/ALK1 in TGF-?/Smad1 signaling in SSc fibroblasts...
  81. Gregory A, Xu G, Sotov V, Letarte M. Review: the enigmatic role of endoglin in the placenta. Placenta. 2014;35 Suppl:S93-9 pubmed publisher
    The cellular expression, structure and function of endoglin, and its implication in several vascular disorders remain enigmatic, even 30 years after its discovery...
  82. Yu J, Zhang X, Liao Y, Zhang Q, Chen H, Lin M, et al. Relationship between expression of CD105 and growth factors in malignant tumors of gastrointestinal tract and its significance. World J Gastroenterol. 2003;9:2866-9 pubmed
    ..At the same time, we also observed the localization of TGF-beta1 and its receptor CD105 in gastric malignant tumors...
  83. Gómez Esquer F, Agudo D, Martínez Arribas F, Núñez Villar M, Schneider J. mRNA expression of the angiogenesis markers VEGF and CD105 (endoglin) in human breast cancer. Anticancer Res. 2004;24:1581-5 pubmed
    Both VEGF and CD105 (endoglin) have been identified as markers of tumor angiogenesis and prognosis in breast cancer. They have always been studied in this kind of tumor by means of immunological methods...
  84. Letteboer T, Zewald R, Kamping E, de Haas G, Mager J, Snijder R, et al. Hereditary hemorrhagic telangiectasia: ENG and ALK-1 mutations in Dutch patients. Hum Genet. 2005;116:8-16 pubmed
    ..Mutations in the genes encoding endoglin (ENG, chromosome 9q34) and activin A receptor type-like kinase 1 (ALK-1, also named ACVRL1, chromosome 12q13) are ..
  85. Schulte C, Geisthoff U, Lux A, Kupka S, Zenner H, Blin N, et al. High frequency of ENG and ALK1/ACVRL1 mutations in German HHT patients. Hum Mutat. 2005;25:595 pubmed
    ..Our results demonstrate the importance of ACVRL1 and ENG mutations in German HHT patients displaying mutation frequencies over 80%. ..
  86. Peters D, Kassam A, Chang Y. A DNA sequence polymorphism in the endoglin gene is not associated with intracranial aneurysm or aneurysmal subarachnoid hemorrhage. Cerebrovasc Dis. 2005;20:96-100 pubmed
    b>Endoglin is a member of the transforming growth factor beta family of proteins and plays a central role in vascular growth and development...
  87. Lopez Novoa J. Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia. Nephrol Dial Transplant. 2007;22:712-4 pubmed
  88. Blanco F, Grande M, Langa C, Oujo B, Velasco S, Rodriguez Barbero A, et al. S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology. Circ Res. 2008;103:1383-92 pubmed publisher
    ..Here, we have analyzed the expression, during EC senescence, of 2 different isoforms (L, long; S, short) of endoglin, an auxiliary transforming growth factor (TGF)-beta receptor involved in vascular remodeling and angiogenesis...
  89. Valeria B, Maddalena G, Enrica V, Onofrio T, Gaetano B. Endoglin (CD105) expression in the human heart throughout gestation: an immunohistochemical study. Reprod Sci. 2008;15:1018-26 pubmed publisher
    b>Endoglin is an 180 KDa protein which plays an important role in the vascular system and cardiac embryogenesis...
  90. Staff A, Harsem N, Braekke K, Hyer M, Hoover R, Troisi R. Maternal, gestational and neonatal characteristics and maternal angiogenic factors in normotensive pregnancies. Eur J Obstet Gynecol Reprod Biol. 2009;143:29-33 pubmed publisher
    ..placental growth factor (PlGF), antiangiogenic soluble fms-like tyrosine kinase receptor (sFlt1) and soluble endoglin (sEng), as well as the antiangiogenic ratios sFlt1/PlGF and (sFlt1+sEng)/PlGF were analyzed in 43 normotensive ..
  91. Wooderchak W, Gedge F, McDonald M, Krautscheid P, Wang X, Malkiewicz J, et al. Hereditary hemorrhagic telangiectasia: two distinct ENG deletions in one family. Clin Genet. 2010;78:484-9 pubmed publisher
    ..Mutations in endoglin (ENG) or activin A receptor type II-like 1 (ACVRL1) account for around 90% of HHT patients, 10% of those are ..
  92. Valbuena Diez A, Blanco F, Oujo B, Langa C, Gonzalez Nuñez M, Llano E, et al. Oxysterol-induced soluble endoglin release and its involvement in hypertension. Circulation. 2012;126:2612-24 pubmed publisher
    ..is considered the base of the pathogenesis of preeclampsia, a pregnancy-specific syndrome in which soluble endoglin (sEng) is a prognostic marker and plays a pathogenic role...