CD10

Summary

Gene Symbol: CD10
Description: membrane metalloendopeptidase
Alias: CALLA, CD10, CMT2T, NEP, SCA43, SFE, neprilysin, atriopeptidase, common acute lymphocytic leukemia antigen, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), membrane metallo-endopeptidase variant 1, membrane metallo-endopeptidase variant 2, neprilysin-390, neprilysin-411, neutral endopeptidase 24.11, skin fibroblast elastase
Species: human
Products:     CD10

Top Publications

  1. Hama E, Shirotani K, Iwata N, Saido T. Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons. J Biol Chem. 2004;279:30259-64 pubmed
    b>Neprilysin (NEP) is a rate-limiting amyloid beta peptide (Abeta)-degrading enzyme in the brain...
  2. Masloub S, Abdel Azim A, Elhamid E. CD10 and osteopontin expression in dentigerous cyst and ameloblastoma. Diagn Pathol. 2011;6:44 pubmed publisher
    To investigate the expression of CD10 and osteopontin in dentigerous cyst and ameloblastoma and to correlate their expression with neoplastic potentiality of dentigerous cyst and local invasion and risk of local recurrence in ameloblastoma...
  3. Cui L, Ohuchida K, Mizumoto K, Moriyama T, Onimaru M, Nakata K, et al. Prospectively isolated cancer-associated CD10(+) fibroblasts have stronger interactions with CD133(+) colon cancer cells than with CD133(-) cancer cells. PLoS ONE. 2010;5:e12121 pubmed publisher
    ..colon cancer cells, with a particular focus on their interactions with cancer-associated fibroblasts, especially CD10+ fibroblasts...
  4. Goodman O, Febbraio M, Simantov R, Zheng R, Shen R, Silverstein R, et al. Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2. J Biol Chem. 2006;281:33597-605 pubmed
    b>Neprilysin is a cell surface peptidase that catalytically inactivates neuropeptide substrates and functions as a tumor suppressor via its enzymatic function and multiple protein-protein interactions...
  5. Osman I, Yee H, Taneja S, Levinson B, Zeleniuch Jacquotte A, Chang C, et al. Neutral endopeptidase protein expression and prognosis in localized prostate cancer. Clin Cancer Res. 2004;10:4096-100 pubmed
    Neutral endopeptidase (NEP) is a cell-surface peptidase that inactivates neuropeptide growth factors implicated in prostate cancer progression. The clinical significance of decreased NEP expression observed in prostate cancer is unclear...
  6. Wang S, Wang R, Chen L, Bennett D, Dickson D, Wang D. Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain. J Neurochem. 2010;115:47-57 pubmed publisher
    ..The major A?-degrading enzymes are neprilysin (NEP), insulin-degrading enzyme (IDE), and endothelin-converting enzyme (ECE-1)...
  7. Oefner C, D Arcy A, Hennig M, Winkler F, Dale G. Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon. J Mol Biol. 2000;296:341-9 pubmed
    ..Here we describe the crystal structure of the extracellular domain (residues 52-749) of human NEP complexed with the generic metalloproteinase inhibitor phosphoramidon at 2.1 A resolution...
  8. Renneberg H, Albrecht M, Kurek R, Krause E, Lottspeich F, Aumuller G, et al. Identification and characterization of neutral endopeptidase (EC 3. 4. 24. 11) from human prostasomes--localization in prostatic tissue and cell lines. Prostate. 2001;46:173-83 pubmed
    ..as well as mono-saccharide analysis and lectin binding and identified as a prostasomal neutral endopeptidase (NEP, EC 3.4.24.11)...
  9. Kanitakis J, Narvaez D, Claudy A. Differential expression of the CD10 antigen (neutral endopeptidase) in primary versus metastatic malignant melanomas of the skin. Melanoma Res. 2002;12:241-4 pubmed
    The CD10 antigen is a neutral endopeptidase expressed by a variety of mesenchymal tumours (haemopoietic or not), including a subset of malignant melanomas...

More Information

Publications91

  1. Piattelli A, Fioroni M, Iezzi G, Perrotti V, Stellini E, Piattelli M, et al. CD10 expression in stromal cells of oral cavity squamous cell carcinoma: a clinic and pathologic correlation. Oral Dis. 2006;12:301-4 pubmed
    b>CD10 is expressed on the majority of follicle-center lymphomas and Burkitt lymphomas. CD10 has also been shown to be present in a variety of other neoplasms...
  2. Martignoni G, Pea M, Brunelli M, Chilosi M, Zamo A, Bertaso M, et al. CD10 is expressed in a subset of chromophobe renal cell carcinomas. Mod Pathol. 2004;17:1455-63 pubmed
    b>CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas...
  3. Gurel D, Kargi A, Karaman I, Onen A, Unlu M. CD10 expression in epithelial and stromal cells of non-small cell lung carcinoma (NSCLC): a clinic and pathologic correlation. Pathol Oncol Res. 2012;18:153-60 pubmed publisher
    b>CD10 is a zinc dependent metallopeptidase, and its expression in stromal and/or epithelial cells of many carcinomas has been suggested to have prognostic value...
  4. Maguer Satta V, Besancon R, Bachelard Cascales E. Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer. Stem Cells. 2011;29:389-96 pubmed publisher
    b>CD10 is a remarkable member of the major class of widely expressed cell surface proteins, endopeptidases...
  5. Fleischmann A, Schlomm T, Huland H, Kollermann J, Simon P, Mirlacher M, et al. Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients. Clin Cancer Res. 2008;14:7838-42 pubmed publisher
    Neutral endopeptidase (CD10), an ectopeptidase bound to the cell surface, is thought to be a potential prognostic marker for prostate cancer...
  6. Dall Era M, True L, Siegel A, Porter M, Sherertz T, Liu A. Differential expression of CD10 in prostate cancer and its clinical implication. BMC Urol. 2007;7:3 pubmed
    b>CD10 is a transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors...
  7. Mitra R, Chao O, Nanus D, Goodman O. Negative regulation of NEP expression by hypoxia. Prostate. 2013;73:706-14 pubmed publisher
    Neutral endopeptidase (NEP) is a transmembrane cell surface peptidase present on prostatic epithelial cells that catalytically inactivates small peptide substrates...
  8. Cohen A, Bunn P, Franklin W, Magill Solc C, Hartmann C, Helfrich B, et al. Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux. Cancer Res. 1996;56:831-9 pubmed
    Neutral endopeptidase (NEP; CALLA, CD10, EC 3.4.24.11) is a cell surface endopeptidase that hydrolyses bioactive peptides, including the bombesin-like peptides, as well as other neuropeptides...
  9. Bachelard Cascales E, Chapellier M, Delay E, Pochon G, Voeltzel T, Puisieux A, et al. The CD10 enzyme is a key player to identify and regulate human mammary stem cells. Stem Cells. 2010;28:1081-8 pubmed publisher
    ..Cells in the outer layer express CD10, a zinc-dependent metalloprotease that regulates the growth of the ductal tree during mammary gland development...
  10. Dall Era M, Oudes A, Martin D, Liu A. HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. Prostate. 2007;67:714-21 pubmed
    b>CD10 is an approximately 100 kDa transmembrane metallo-endopeptidase. CD10 is strongly expressed by normal prostate epithelium. While only 30% of primary prostate tumors express CD10, it is strongly expressed by most lymph node metastases...
  11. Morisaki N, Moriwaki S, Sugiyama Nakagiri Y, Haketa K, Takema Y, Imokawa G. Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses. J Biol Chem. 2010;285:39819-27 pubmed publisher
    ..As there are similarities in the molecular weights and inhibitory profiles of HSF elastase and neprilysin (neutral endopeptidase 24...
  12. Bilalovic N, Sandstad B, Golouh R, Nesland J, Selak I, Torlakovic E. CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression. Mod Pathol. 2004;17:1251-8 pubmed
    b>CD10 antigen is a 100-kDa-cell surface zinc metalloendopeptidase expressed in a variety of normal and neoplastic lymphoid and nonlymphoid tissues including melanomas...
  13. Ganju R, Shpektor R, Brenner D, Shipp M. CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase. Blood. 1996;88:4159-65 pubmed
    b>CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation...
  14. Farris W, Schütz S, Cirrito J, Shankar G, Sun X, George A, et al. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007;171:241-51 pubmed
    ..There is evidence that the Abeta-degrading protease neprilysin (NEP) is down-regulated in normal aging and LOAD...
  15. Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, et al. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci. 2004;24:991-8 pubmed
    ..Here, we report on the catabolic mechanism of Abeta at the presynaptic sites. Neprilysin, an Abeta-degrading enzyme, expressed by recombinant adeno-associated viral vector-mediated gene transfer, was ..
  16. Göhring B, Holzhausen H, Meye A, Heynemann H, Rebmann U, Langner J, et al. Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer. Int J Mol Med. 1998;2:409-14 pubmed
    ..We describe the down-regulation of neutral endopeptidase 24.11 (NEP) protein expression in RCC of the clear cell/chromophilic type when compared with renal parenchyma, and show for ..
  17. Siepmann M, Kumar S, Mayer G, Walter J. Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt. PLoS ONE. 2010;5: pubmed publisher
    b>Neprilysin (NEP) is a type II membrane metalloproteinase that cleaves physiologically active peptides at the cell surface thus regulating the local concentration of these peptides available for receptor binding and signal transduction...
  18. Shipp M, Tarr G, Chen C, Switzer S, Hersh L, Stein H, et al. CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci U S A. 1991;88:10662-6 pubmed
    ..that these malignant pulmonary neuroendocrine cells express low levels of the cell surface metalloendopeptidase CD10/neutral endopeptidase 24...
  19. Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, et al. Cell surface expression of the major amyloid-? peptide (A?)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1. J Biol Chem. 2012;287:29362-72 pubmed publisher
    b>Neprilysin is one of the major amyloid-? peptide (A?)-degrading enzymes, the expression of which declines in the brain during aging...
  20. Ogawa H, Iwaya K, Izumi M, Kuroda M, Serizawa H, Koyanagi Y, et al. Expression of CD10 by stromal cells during colorectal tumor development. Hum Pathol. 2002;33:806-11 pubmed
    b>CD10 is a cell surface metalloprotease expressed by a variety of normal cell types, including lymphoid precursor cells, germinal center B lymphocytes, and some epithelial cells...
  21. Iwaya K, Ogawa H, Izumi M, Kuroda M, Mukai K. Stromal expression of CD10 in invasive breast carcinoma: a new predictor of clinical outcome. Virchows Arch. 2002;440:589-93 pubmed
    b>CD10 is a cell surface neutral endopeptidase that is not consistently expressed in the stromal cells of the normal breast...
  22. Marr R, Rockenstein E, Mukherjee A, Kindy M, Hersh L, Gage F, et al. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci. 2003;23:1992-6 pubmed
    ..b>Neprilysin has recently been implicated as a major extracellular Abeta degrading enzyme in the brain...
  23. Mazurov D, Barbashova L, Filatov A. Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes. FEBS J. 2013;280:1200-13 pubmed publisher
    ..In this article, we describe a new partner of tetraspanin web, membrane metalloprotease CD10, which is selectively associated with CD9...
  24. Rossi M, Yokota T, Medina K, Garrett K, Comp P, Schipul A, et al. B lymphopoiesis is active throughout human life, but there are developmental age-related changes. Blood. 2003;101:576-84 pubmed
    ..However, sorted CD34(+) Lin(-) CD10(+) progenitors from cord blood and adult marrow had equivalent potential for differentiation in culture, and ..
  25. Schroeter P, Sablotzki A, Riemann D. CD13 and CD10 expression of granulocytes as markers for the functioning of the immune system: quantification of the expression of membrane molecules using 1:1 labeled monoclonal antibodies and flow cytometry. Methods Mol Biol. 2007;378:71-81 pubmed publisher
    ..In the peripheral blood of patients with open heart surgery the expression of the membrane peptidases neprilysin/CD10 and aminopeptidase N/CD13, was determined on granulocytes in comparison to the monocytic HLA-DR expression...
  26. Jordan J, Stinkens R, Jax T, Engeli S, Blaak E, May M, et al. Improved Insulin Sensitivity With Angiotensin Receptor Neprilysin Inhibition in Individuals With Obesity and Hypertension. Clin Pharmacol Ther. 2017;101:254-263 pubmed publisher
    ..We hypothesized that sacubitril/valsartan (LCZ696), which augments NP through neprilysin inhibition while blocking angiotensin II type-1 (AT1 )-receptors, improves insulin sensitivity, lipid ..
  27. Muangman P, Spenny M, Tamura R, Gibran N. Fatty acids and glucose increase neutral endopeptidase activity in human microvascular endothelial cells. Shock. 2003;19:508-12 pubmed
    Neutral endopeptidase (NEP), a membrane-bound metallopeptidase enzyme that degrades neuropeptides, bradykinin, atrial natriuretic factor, enkephalins, and endothelin may regulate response to injury...
  28. Van Kampen J, Kay D. Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease. PLoS ONE. 2017;12:e0182896 pubmed publisher
    ..The overexpression of PGRN was also found to increase activity of neprilysin, a key amyloid beta degrading enzyme...
  29. Wu X, Wu X, Li W, Cheng X. Molecular characterization of a divergent strain of calla lily chlorotic spot virus infecting celtuce (Lactuca sativa var. augustana) in China. Arch Virol. 2018;163:1375-1378 pubmed publisher
    ..25%) with that of calla lily chlorotic spot virus isolated from calla lily (CCSV-calla) [China: Taiwan: 2001] and tobacco (CCSV-LJ1) [..
  30. Okumura N, Jhund P, Gong J, Lefkowitz M, Rizkala A, Rouleau J, et al. Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy. Circ Heart Fail. 2016;9: pubmed publisher
    ..ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the angiotensin-converting enzyme inhibitorenalapril in ..
  31. Shen L, Zhang Y, Bai Y, Zheng X, Wang Q, Huang J. A filterless, visible-blind, narrow-band, and near-infrared photodetector with a gain. Nanoscale. 2016;8:12990-7 pubmed publisher
    ..We directly measured a noise equivalent power (NEP) of 6.1 pW cm(-2) at 890 nm, and a large linear dynamic range (LDR) over 11 orders of magnitude...
  32. Olds K, Heath K, Miliauskas J, Byard R. Occult cardiac lymphoma and sudden death. Forensic Sci Med Pathol. 2018;: pubmed publisher
    ..scattered large lymphocytes amounting to a low-grade follicular non-Hodgkin lymphoma, as tumor cells were CD20, CD10, Bcl 2 and LMO 2 positive...
  33. Villalaín González C, Tejerizo García Ã, Lopez Garcia P, López González G, Oliver Perez M, Jiménez López J. Vaginal metastasis as the initial presentation of leiomyosarcoma: a case report. BMC Cancer. 2017;17:503 pubmed publisher
    ..to a vaginal epithelioid lesion; marker expression changed from the uterine tumor actin+/desmin+/caldesmon+/CD10- phenotype, through the tumor emboli, to an actin-/desmin-/caldesmon-/CD10+ phenotype in the vaginal lesion...
  34. Sinsabaugh R, Moorhead D, Xu X, Litvak M. Plant, microbial and ecosystem carbon use efficiencies interact to stabilize microbial growth as a fraction of gross primary production. New Phytol. 2017;214:1518-1526 pubmed publisher
    ..Ecosystem CUEe , the ratio of net ecosystem production (NEP) to GPP, was estimated for each site using published models...
  35. Cordone I, Masi S, Carosi M, Vidiri A, Marchesi F, Marino M, et al. Brain stereotactic biopsy flow cytometry for central nervous system lymphoma characterization: advantages and pitfalls. J Exp Clin Cancer Res. 2016;35:128 pubmed publisher
    ..All were of B cell type, with a heterogeneous CD20 mean fluorescence intensity (MFI), CD10 positive in 3 cases (19 %) with surface Ig light chain restriction documented in 11 cases (69 %)...
  36. Zhou W, Saam T, Zhou Y, Trevino J, Liu X, Cao D, et al. Pancreatic Mucinous Cystic Neoplasm Communicating with Main Pancreatic Duct: An Unrecognized Presentation of Pancreatic Mucinous Neoplasm?. Anticancer Res. 2017;37:7017-7021 pubmed
    ..stains confirmed that the stroma cells were positive for ER, PR, alpha-inhibin and focally positive for CD10. The final pathologic diagnosis was pancreatic mucinous cystic neoplasm communicating with the main pancreatic duct...
  37. Trivedi R, Polhemus D, Li Z, Yoo D, Koiwaya H, Scarborough A, et al. Combined Angiotensin Receptor-Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure. J Am Heart Assoc. 2018;7: pubmed publisher
    ..Sacubitril/valsartan-mediated improvements in cardiac and vascular function are likely related to increases in NO bioavailability and explain, in part, the benefits beyond angiotensin receptor blockade. ..
  38. Kim H, Shin M, Cheon M, Kim J, Lee C, Kim W, et al. GREM1 is expressed in the cancer-associated myofibroblasts of basal cell carcinomas. PLoS ONE. 2017;12:e0174565 pubmed publisher
    ..Additionally, in BCCs, stromal GREM1 expression had a strong correlation with CD10 expression...
  39. Demaret J, Venet F, Plassais J, Cazalis M, Vallin H, Friggeri A, et al. Identification of CD177 as the most dysregulated parameter in a microarray study of purified neutrophils from septic shock patients. Immunol Lett. 2016;178:122-30 pubmed publisher
    ..In addition, this up-regulation was negatively correlated with a decreased expression of CD10, a characteristic of immature myeloid cells...
  40. Skenderi F, Ulamec M, Vranic S, Bilalovic N, Peckova K, Rotterova P, et al. Cystic Renal Oncocytoma and Tubulocystic Renal Cell Carcinoma: Morphologic and Immunohistochemical Comparative Study. Appl Immunohistochem Mol Morphol. 2016;24:112-9 pubmed publisher
    ..Immunohistochemical panel included various cytokeratins (AE1-AE3, OSCAR, CAM5.2, CK7), vimentin, CD10, CD117, AMACR, CA-IX, antimitochondrial antigen (MIA), EMA, and Ki-67...
  41. Wang J, Nguyen G, Ruan J, Magro C. Primary Cutaneous Follicular Helper T-Cell Lymphoma: A Case Series and Review of the Literature. Am J Dermatopathol. 2017;39:374-383 pubmed publisher
    ..T cells that express an array of Tfh markers, such as inducible T-cell costimulator, Bcl-6, CXCL13, PD-1, and CD10. The authors now present 3 patients whose known clinical skin findings are consistent with PTCL of Tfh origin (PTCL-..
  42. Katsi V, Skalis G, Pavlidis A, Makris T, Nihoyannopoulos P, Tousoulis D, et al. Angiotensin receptor neprilysin inhibitor LCZ696: a novel targeted therapy for arterial hypertension?. Eur Heart J Cardiovasc Pharmacother. 2015;1:260-4 pubmed publisher
    ..LCZ696 is a first-in-class angiotensin receptor neprilysin inhibitor that has been shown to enhance endogenous natriuretic peptide (NP) actions on neurohormonal activation...
  43. Mancini G, Howlett J, Borer J, Liu P, Mehra M, Pfeffer M, et al. Pharmacologic Options for the Management of Systolic Heart Failure: Examining Underlying Mechanisms. Can J Cardiol. 2015;31:1282-92 pubmed publisher
    ..Also, a new drug that incorporates neprilysin inhibition combined with angiotensin receptor blockade shows incremental effectiveness...
  44. Joshi P, Modur V, Cheng J, Robinson K, Rao K. Characterization of immortalized human mammary epithelial cell line HMEC 2.6. Tumour Biol. 2017;39:1010428317724283 pubmed publisher
    ..The cell line expressed basal epithelial markers such as cytokeratin 7, CD10, and p63 and was negative for the expression of estrogen receptor and progesterone receptor...
  45. Abdel Aziz A, Amin M. EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence. Diagn Pathol. 2012;7:14 pubmed publisher
    ..Studying the role played by EGFR, CD10 and Ki67 in the recurrence of ameloblastoma...
  46. Zheng K, Liu H, Yin Y, Chen T, Yeh S, Zhang Z, et al. Full-length M and L RNA sequences of tospovirus isolate 2009-GZT, which causes necrotic ringspot on tomato in China. Arch Virol. 2016;161:1411-4 pubmed publisher
    ..The RdRp of TNSaV shares the highest aa sequence identity (85.2 %) with that of calla lily chlorotic spot virus (CCSV)...
  47. Finn K, Greenwald J. Update in hospital medicine: Evidence you should know. J Hosp Med. 2015;10:817-26 pubmed publisher
    ..The findings, cautions, and implications are discussed for each paper. Key findings include: a novel neprilysin inhibitor and angiotensin receptor blocker combination drug reduces mortality in patients with heart failure; ..
  48. Hormann S, Davis L, Pogge E. From Theory to Practice: The Diuretic Potential of Sacubitril/Valsartan: A Tale of 2 Patients. J Cardiovasc Nurs. 2017;: pubmed publisher
    ..Consensus guidelines updated in 2016 recommend an angiotensin receptor-neprilysin inhibitor (ARNi) as a therapeutic option in lieu of an angiotensin-converting enzyme inhibitor or angiotensin ..
  49. Lloyd J, Owens S. CD10 immunohistochemistry stains enteric mucosa, but negative staining is unreliable in the setting of active enteritis. Mod Pathol. 2011;24:1627-32 pubmed publisher
    ..We explored the utility of CD10 immunohistochemistry to aid diagnosis in this clinical setting by highlighting the enteric mucosa, based on ..
  50. Povsic T, Scott R, Mahaffey K, BLAUSTEIN R, Edelberg J, Lefkowitz M, et al. Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference. Cardiovasc Drugs Ther. 2017;31:445-458 pubmed publisher
    ..to targeted drug development, highlighting successes (protein convertase sutilisin/kexin type 9 [PCSK9] and neprilysin inhibition) and targets still under evaluation (cholesteryl ester transfer protein [CETP] inhibition), with the ..
  51. Demaret J, Venet F, Friggeri A, Cazalis M, Plassais J, Jallades L, et al. Marked alterations of neutrophil functions during sepsis-induced immunosuppression. J Leukoc Biol. 2015;98:1081-90 pubmed publisher
    ..e., CD10(dim)CD16(dim)). These aspects were associated with an increased risk of death after septic shock...
  52. Podder S, Khetan P, Sivamurthy S, Mandal K. Rare presentation of orbital plasmablastic lymphoma with oral cavity involvement in an HIV-negative patient. BMJ Case Rep. 2015;2015: pubmed publisher
    ..A small subset of markers was weakly positive for CD20, CD30 and κ, and negative for CD10, BCL-6, CD4, CD56 and Epstein-Barr virus-encoded small RNA (EBER)...
  53. Bettencourt P, Fonseca C, Franco F, Andrade A, Brito D. Interpretation of B-type natriuretic peptides in the era of angiotensin receptor-neprilysin inhibitors. Rev Port Cardiol. 2017;36:881-884 pubmed publisher
    ..Following the recent advent of angiotensin receptor-neprilysin inhibitors (ARNIs), there is a need to review how these two biomarkers are interpreted in HF...
  54. Ffrench B, Gasch C, Hokamp K, Spillane C, Blackshields G, Mahgoub T, et al. CD10-/ALDH- cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy. Cell Death Dis. 2017;8:e3128 pubmed publisher
    ..validation, we report a novel, four-component CSC hierarchy based around the markers cluster of differentiation 10 (CD10) and aldehyde dehydrogenase (ALDH)...
  55. Khanh D, Mekata E, Mukaisho K, Sugihara H, Shimizu T, Shiomi H, et al. Transmembrane mucin MUC1 overexpression and its association with CD10? myeloid cells, transforming growth factor-?1 expression, and tumor budding grade in colorectal cancer. Cancer Sci. 2013;104:958-64 pubmed publisher
    ..association between mucin expression and other previously reported prognostic factors, including infiltration of CD10? myeloid cells, transforming growth factor-?1 (TGF-?1) expression, and tumor budding at invasion fronts...
  56. Rice G, Thomas D, Grant P, Turner A, Hooper N. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J. 2004;383:45-51 pubmed
    ..cleavage by full-length human ACE, the separate N- and C-domains of ACE, the homologue of ACE, ACE2, and NEP (neprilysin)...
  57. Tummala R, Bhadra R, Gupta A, Ghosh R. Combined Neprilysin and RAS Inhibition in Cardiovascular Diseases: A Review of Clinical Studies. J Cardiovasc Pharmacol. 2016;68:183-90 pubmed publisher
    ..the management of heart failure (HF) and other cardiovascular diseases: the renin-angiotensin-aldosterone system-neprilysin combination inhibitors, also called angiotensin receptor neprilysin inhibitor, valsartan/sacubitril (LCZ696)...
  58. Meriden Z, Shi C, Edil B, Ellison T, Wolfgang C, Cornish T, et al. Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol. 2011;35:981-8 pubmed publisher
    ..These 6 cases, which also demonstrated cytoplasmic CD10 staining, were reclassified as SPNs...
  59. Theodorakopoulou E, Gennimata S, Harikiopoulou M, Kaltsakas G, Palamidas A, Koutsoukou A, et al. Effect of pulmonary rehabilitation on tidal expiratory flow limitation at rest and during exercise in COPD patients. Respir Physiol Neurobiol. 2017;238:47-54 pubmed publisher
    ..EFL and dynamic hyperinflation (DH) were documented using the negative expiratory pressure (NEP) technique and inspiratory capacity (IC) maneuvers, respectively...
  60. Li L, Wang Y, Beringer J, Shi H, Cleverly J, Cheng L, et al. Responses of LAI to rainfall explain contrasting sensitivities to carbon uptake between forest and non-forest ecosystems in Australia. Sci Rep. 2017;7:11720 pubmed publisher
    ..ecosystems, both GPP and Re increased with rainfall, and, consequently net ecosystem production (NEP) increased with rainfall. In forest ecosystems, GPP and Re were insensitive to rainfall...
  61. Reagan P, Davies A. Current treatment of double hit and double expressor lymphoma. Hematology Am Soc Hematol Educ Program. 2017;2017:295-297 pubmed publisher
    ..The final pathology, however, revealed infiltration with medium-sized atypical lymphoid cells positive for CD20, CD10, MYC, BLC2, and BCL6 by immunohistochemistry...
  62. Voutsadakis I, Vlachostergios P, Daliani D, Karasavvidou F, Kakkas G, Moutzouris G, et al. CD10 is inversely associated with nuclear factor-kappa B and predicts biochemical recurrence after radical prostatectomy. Urol Int. 2012;88:158-64 pubmed publisher
    The cell surface endopeptidase CD10 (neutral endopeptidase) and nuclear factor-?B (NF-?B) have been independently associated with prostate cancer (PC) progression...
  63. Le Moual H, Dion N, Roques B, Crine P, Boileau G. Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11. Eur J Biochem. 1994;221:475-80 pubmed
    Neutral endopeptidase (NEP) is a membrane-bound mammalian ectopeptidase that contains a catalytic zinc ion in its active site...
  64. Ramezani M, Mohamadzaheri E, Khazaei S, Najafi F, Vaisi raygani A, Rahbar M, et al. Comparison of EMA,CEA, CD10 and Bcl-2 Biomarkers by Immunohistochemistry in Squamous Cell Carcinoma and Basal Cell Carcinoma of the Skin. Asian Pac J Cancer Prev. 2016;17:1379-83 pubmed
    ..IHC was used with antibodies to Bcl-2, CD10, CEA, and EMA biomarkers, which despite non-specificity are easily available for detection of various types of ..
  65. Kumagai R, Kohashi K, Takahashi S, Yamamoto H, Hirahashi M, Taguchi K, et al. Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine. World J Gastroenterol. 2015;21:2700-10 pubmed publisher
    ..venous invasion, and lymph node metastasis), and the immunohistochemical expression of MUC5AC, MUC6, MUC2, CD10, and mismatch-repair (MMR) proteins (MLH1 and MSH2)...
  66. Iwase A, Kotani T, Goto M, Kobayashi H, Takikawa S, Nakahara T, et al. Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion. Reprod Sci. 2014;21:82-8 pubmed publisher
    ..b>CD10 is known to be expressed by endometrial and endometriotic stromal cells and may be induced by progestins, although ..
  67. Del Sordo R, Ascani S, Bellezza G, Ferri I, Sbaraglia M, Sidoni A. CD10 is frequently expressed in classical seminomas. Histol Histopathol. 2014;29:101-6 pubmed publisher
    b>CD10 is a cell surface metalloproteinase widely expressed in various normal tissue and in epithelial, stromal or both components of various malignancies...
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    ..antigenicity in the wake of diffuse TBI and present the hypothesis that the Nogo-66 receptor antagonist peptide NEP(1-40) would reverse the injury-induced shift in distribution of microglia morphologies by limiting myelin-based ..
  69. Atkins H, Caudell D, Hutchison A, LeGrande A, Kock N. Abdominal Wall Endometriosis in a Rhesus Macaque (Macaca mulatta). Comp Med. 2017;67:277-280 pubmed
    ..The stroma was strongly positive for vimentin and CD10 but was rarely, weakly positive for estrogen receptors and negative for progesterone...
  70. Goteri G, Lucarini G, Zizzi A, Costagliola A, Giantomassi F, Stramazzotti D, et al. Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas. Diagn Pathol. 2011;6:97 pubmed publisher
    ..germinal center-associated lymphoma (HGAL) gene protein has been proposed as an adjunctive follicular marker to CD10 and BCL6...
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    Neutral endopeptidase (NEP) alloimmunization has recently been determined to cause severe forms of neonatal disease as a result of the transplacental passage of anti-NEP antibodies...
  72. Furumatsu T, Kodama Y, Kamatsuki Y, Hino T, Ozaki T. Arthroscopic Repair of the Medial Meniscus Radial/Oblique Tear Prevents the Progression of Meniscal Extrusion in Mildly Osteoarthritic Knees. Acta Med Okayama. 2017;71:413-418 pubmed publisher
    ..Our results suggest that all-inside meniscal repairs would be useful in preventing the progression of MME in patients suffering from symptomatic MM radial/oblique tears associated with mildly osteoarthritic knees. ..
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    ..In this study, we examined the ability of the peptidase neprilysin to cleave IAPP and prevent human IAPP-induced pancreatic beta cell toxicity...
  74. D ADAMIO L, Shipp M, Masteller E, Reinherz E. Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions. Proc Natl Acad Sci U S A. 1989;86:7103-7 pubmed
    The common acute lymphoblastic leukemia antigen (CALLA) is a 749-amino acid type II integral membrane protein that has been identified recently as the neutral endopeptidase 24.11 [NEP (EC 3.4.24.11)]...
  75. Weinreb I, Cunningham K, Perez Ordonez B, Hwang D. CD10 is expressed in most epithelioid hemangioendotheliomas: a potential diagnostic pitfall. Arch Pathol Lab Med. 2009;133:1965-8 pubmed publisher
    ..We recently encountered an EHE with strong CD10 positivity mimicking renal cell carcinoma. -To examine sensitivity and specificity of CD10 in EHE...
  76. Youssef N, M Ruemmele F, Goulet O, Patey N. [CD10 expression in a case of microvillous inclusion disease]. Ann Pathol. 2004;24:624-7 pubmed
    ..We report a case of microvillous atrophy who undergone a combined bowel, colonic and liver transplantation, and discuss the tools allowing the light microscopic diagnosis. ..
  77. Tretiakova M, Antic T, Westerhoff M, Mueller J, Himmelfarb E, Wang H, et al. Diagnostic utility of CD10 in benign and malignant extrahepatic bile duct lesions. Am J Surg Pathol. 2012;36:101-8 pubmed publisher
    b>CD10, a cell surface enzyme with neutral metalloendopeptidase activity, is a marker for intestinal epithelial brush border. It is also present in normal bile ducts and gallbladder epithelia but is absent in cholangiocarcinomas...
  78. Arrigo M, Vodovar N, Nougué H, Sadoune M, Pemberton C, Ballan P, et al. The heart regulates the endocrine response to heart failure: cardiac contribution to circulating neprilysin. Eur Heart J. 2017;: pubmed publisher
    ..undergoing implantation of the CARMAT total artificial heart and investigating regional differences in soluble neprilysin (sNEP) in patients with reduced or preserved systolic function, we studied the regulation of the NP pathway in HF...
  79. Brezina V, Bank B, Cropper E, Rosen S, Vilim F, Kupfermann I, et al. Nine members of the myomodulin family of peptide cotransmitters at the B16-ARC neuromuscular junction of Aplysia. J Neurophysiol. 1995;74:54-72 pubmed
    ..abstract truncated at 400 words)..
  80. Salibay C, Rewerska J, Gupta S, Ree N. Primary Carcinosarcoma of the Pancreas With CD10-Positive Sarcoma Component. J Investig Med High Impact Case Rep. 2017;5:2324709617740906 pubmed publisher
    ..In addition, the sarcomatous component showed diffuse immunoreactivity for CD10 with a surrounding myofibroblastic proliferation...
  81. Glossop M, Bazin R, Dack K, Fox D, Macdonald G, MILLS M, et al. Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors. Bioorg Med Chem Lett. 2011;21:3404-6 pubmed publisher
    Heteroarylalanine derivatives 4 were designed as potential inhibitors of neutral endopeptidase (NEP EC 3.4.24.11). Selectivity over other zinc metalloproteinases was explored through occupation of the S2' subsite within NEP...
  82. Hasby E, Saad H. Immunohistochemical expression of Fas ligand (FasL) and neprilysin (neutral endopeptidase/CD10) in keratoconus. Int Ophthalmol. 2013;33:125-31 pubmed publisher
    Recent evidence demonstrated a correlation between apoptosis and neprilysin expression...