CCR2

Summary

Gene Symbol: CCR2
Description: C-C motif chemokine receptor 2
Alias: CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C chemokine receptor type 2, MCP-1 receptor, chemokine (C-C motif) receptor 2, monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor
Species: human
Products:     CCR2

Top Publications

  1. Tanuma N, Sakuma H, Sasaki A, Matsumoto Y. Chemokine expression by astrocytes plays a role in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosis. Acta Neuropathol. 2006;112:195-204 pubmed
    ..protein-1 (MCP-1)/CCL2 and interferon-gamma inducible protein-10 (IP-10)/CXCL10 and their receptors, CCR2 and CXCR3, while these immunoreactivities were weak in the center, thus forming a chemokine gradient...
  2. Kageyama S, Mimaya J, Yamada K, Kurimura T, Shiraki K. Polymorphism of CCR5 affecting HIV disease progression in the Japanese population. AIDS Res Hum Retroviruses. 2001;17:991-5 pubmed
    Among several factors associated with HIV-1 disease progression, genetic polymorphism of CCR2, CCR5, and CXCR4 in HIV-1 infection has been found...
  3. Sohy D, Parmentier M, Springael J. Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. J Biol Chem. 2007;282:30062-9 pubmed
    ..We reported previously the existence of negative binding cooperativity between the subunits of CCR2/CCR5 heterodimers...
  4. Bjarnadottir K, Eiriksdottir G, Aspelund T, Gudnason V. Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on MI in the Icelandic population. Atherosclerosis. 2006;188:341-6 pubmed
    Monocyte chemotactic protein-1 (MCP-1) and its receptor CCR2 may play a role in mediating atherosclerosis...
  5. Tsou C, Peters W, Si Y, Slaymaker S, Aslanian A, Weisberg S, et al. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest. 2007;117:902-9 pubmed
    ..Here we report that CC chemokine receptor 2 (CCR2) is highly expressed on a subpopulation of blood monocytes whose numbers are markedly decreased in CCR2(-/-) mice...
  6. Garcia Lopez M, Aguado Martínez A, Lamaze C, Martinez A C, Fischer T. Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2. Cell Signal. 2009;21:1748-57 pubmed publisher
    ..not universal amongst the GPCR, however, and the precise spatial and temporal events in the internalization of the CCR2 chemokine receptor remain unknown...
  7. Rittig K, Peter A, Baltz K, Tschritter O, Weigert C, Andreozzi F, et al. The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals. Atherosclerosis. 2008;198:338-46 pubmed
    Monocyte-chemoattractant-protein (MCP)-1 and its receptor CCR2 have been shown to play a pivotal role in vascular inflammation and atherosclerotic plaque formation...
  8. Nguyen L, Li M, Chaowanachan T, Hu D, Vanichseni S, Mock P, et al. CCR5 promoter human haplogroups associated with HIV-1 disease progression in Thai injection drug users. AIDS. 2004;18:1327-33 pubmed
    ..5 years (range, 0.2-7.0). From a cohort of 130 IDU, 106 (81.5%) were genotyped for the CCR2b-64I, CCR5-delta32 and seven CCR5 promoter alleles constituting the CCR5 haplogroups...
  9. Coelho A, Matos A, Catarino R, Pinto D, Sousa H, Pereira D, et al. The influence of chemokine receptor CCR2 genotypes in the route to cervical carcinogenesis. Gynecol Obstet Invest. 2007;64:208-12 pubmed
    ..The aim of our study was to analyse the influence of the CCR2-64I polymorphism in the development of SIL due to its preponderant role in the cervical carcinogenesis and in the ..

More Information

Publications65

  1. Katrancioglu N, Manduz S, Karahan O, Yilmaz M, Sezgin I, Bagci G, et al. The role of the CCR2 gene polymorphism in abdominal aortic aneurysms. Angiology. 2011;62:140-3 pubmed publisher
    Chronic inflammation play an important role on abdominal aortic aneurysms (AAA) formation. Chemokine receptor-2 (CCR2) is involved in regulation of the inflammatory response...
  2. Breunis W, Biezeveld M, Geissler J, Kuipers I, Lam J, Ottenkamp J, et al. Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease. Clin Exp Immunol. 2007;150:83-90 pubmed
    ..KD patients and 300 healthy Dutch Caucasian controls, common genetic variants in chemokine receptor genes CCR3, CCR2, CCR5, CX3CR1, CXCR1 and CXCR2 were analysed...
  3. Winkler C, Hendel H, Carrington M, Smith M, Nelson G, O Brien S, et al. Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression. J Acquir Immune Defic Syndr. 2004;37:1534-8 pubmed
    Three haplotypes for the CCR2-CCR5 region previously have been shown to affect AIDS progression; however, it is not known if the protective and accelerating effects of the haplotypes are relatively constant throughout infection or exert ..
  4. Hladik F, Liu H, Speelmon E, Livingston Rosanoff D, Wilson S, Sakchalathorn P, et al. Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J Virol. 2005;79:11677-84 pubmed
    ..they carry the chemokine receptor (CR) gene alleles CCR5 open reading frame (ORF) Delta32, CCR5 promoter -2459G, or CCR2 ORF 64I (CCR2-64I), all of which have been found to diminish HIV-1 infectivity and/or disease progression...
  5. Bose S, Cho J. Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases. Arch Pharm Res. 2013;36:1039-50 pubmed publisher
    ..CCL2 and its receptor CCR2 have been shown to be induced and involved in various neurodegenerative disorders including Alzheimer's disease, ..
  6. Harmon B, Orkunoglu Suer E, Adham K, Larkin J, Gordish Dressman H, Clarkson P, et al. CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance training. J Appl Physiol (1985). 2010;109:1779-85 pubmed publisher
    ..The present study hypothesizes that genetic variations in CCL2 and its receptor (CCR2) may help explain muscle trait variability...
  7. Miyagishi R, Niino M, Fukazawa T, Yabe I, Kikuchi S, Tashiro K. C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosis. J Neuroimmunol. 2003;145:135-8 pubmed
    C-C chemokine receptor 2 (CCR2) is a receptor for chemoattractant protein-1 (MCP-1) and associated with infiltrating lymphocytes in chronic active multiple sclerosis (MS) lesions...
  8. Zheng B, Wiklund F, Gharizadeh B, Sadat M, Gambelunghe G, Hallmans G, et al. Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patients. Anticancer Res. 2006;26:3669-74 pubmed
    ..HPV) infection and cervical cancer with two DNA polymorphisms of the chemokine receptors CCR5-delta32 and CCR2-64I...
  9. Olzinski A, Turner G, Bernard R, Karr H, Cornejo C, Aravindhan K, et al. Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment. Arterioscler Thromb Vasc Biol. 2010;30:253-9 pubmed publisher
    ..Apolipoprotein E(-/-) mice expressing human CCR2 were fed a Western diet (vehicle group) or a Western diet plus10 mg/kg per day of GSK1344386B (GSK1344386B group)...
  10. Huerta C, Alvarez V, Mata I, Coto E, Ribacoba R, Martinez C, et al. Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease. Neurosci Lett. 2004;370:151-4 pubmed
    ..genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD...
  11. Nyquist P, Winkler C, McKenzie L, Yanek L, Becker L, Becker D. Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis. Cerebrovasc Dis. 2009;28:124-30 pubmed publisher
    Monocyte chemoattractant protein 1 (MCP-1), acting in concert with its receptor chemokine receptor 2 (CCR2), promotes recruitment of macrophages into atherosclerotic plaque...
  12. Apostolakis S, Baritaki S, Kochiadakis G, Igoumenidis N, Panutsopulos D, Spandidos D. Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease. Thromb Res. 2007;119:63-71 pubmed
    ..investigated the effect of 5 common variations of chemokine and chemokine receptor genes (SDF1-3'A, CCR5-delta32, CCR2-64I, CX3CR1-V249I and CX3CR1-T280M) on predisposition to CAD...
  13. Mummidi S, Ahuja S, Gonzalez E, Anderson S, Santiago E, Stephan K, et al. Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nat Med. 1998;4:786-93 pubmed
    Allelic variants for the HIV-1 co-receptors chemokine receptor 5 (CCR5) and CCR2, as well as the ligand for the co-receptor CXCR4, stromal-derived factor (SDF-1), have been associated with a delay in disease progression...
  14. Abdi R, Tran T, Sahagun Ruiz A, Murphy P, Brenner B, Milford E, et al. Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation. J Am Soc Nephrol. 2002;13:754-8 pubmed
    ..The association of human chemokine receptor genetic variants, CCR5-Delta32, CCR5-59029-A/G, CCR2-V64I, CX3CR1-V249I, and CX3CR1-T280M, with outcome in 163 renal transplant recipients was examined here...
  15. Su B, Jin L, Hu F, Xiao J, Luo J, Lu D, et al. Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and world populations and its implication in AIDS epidemiology. Am J Hum Genet. 1999;65:1047-53 pubmed
    Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset...
  16. Omrani M, Mokhtari M, Tagizadae A, Bagheri M, Ahmad Poor P. Association of CCR5-59029 A/G and CCR2-V64I variants with renal allograft survival. Iran J Immunol. 2008;5:201-6 pubmed publisher
    ..The aim of current investigation was to study the impact of polymorphisms of CCR5Delta32, CCR5- 59029 A/G and CCR2-V64I on renal allograft survival...
  17. Terashima Y, Onai N, Murai M, Enomoto M, Poonpiriya V, Hamada T, et al. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. Nat Immunol. 2005;6:827-35 pubmed
    Ligation of the chemokine receptor CCR2 on monocytes and macrophages with its ligand CCL2 results in activation of the cascade consisting of phosphatidylinositol-3-OH kinase (PI(3)K), the small G protein Rac and lamellipodium protrusion...
  18. Lu X, Kang Y. Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem. 2009;284:29087-96 pubmed publisher
    ..By performing functional assays with primary cells isolated from the wild type, CCL2 and CCR2 knock-out mice, we showed that tumor cell-derived CCL2 depends on its receptor CCR2 (chemokine, CC motif, receptor ..
  19. Pedersen B, Kamwendo D, Blood M, Mwapasa V, Molyneux M, North K, et al. CCR5 haplotypes and mother-to-child HIV transmission in Malawi. PLoS ONE. 2007;2:e838 pubmed
    CCR5 and CCR2 gene polymorphisms (SNPs) have been associated with protection against HIV transmission in adults and with delayed progression to AIDS...
  20. Su B, Sun G, Lu D, Xiao J, Hu F, Chakraborty R, et al. Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3'A, CCR2-641, and CCR5-delta32) in global populations. Eur J Hum Genet. 2000;8:975-9 pubmed
    Chemokine receptors (CCR5, CXCR4 and CCR2) have been shown to be important co-receptors for HIV infection...
  21. Lin H, Ueng K, Hsieh Y, Chiang W, Yang S, Chu S. Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibility. Mol Biol Rep. 2012;39:9023-30 pubmed publisher
    ..Results also revealed that subjects with at least one A allele of the V64I CCR2 gene polymorphism had significantly increased risk of CAD...
  22. Szalai C, Duba J, Prohaszka Z, Kalina A -, Szabo T, Nagy B, et al. Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients. Atherosclerosis. 2001;158:233-9 pubmed
    ..We investigated the role of these polymorphisms together with the chemokine SDF-1-801A and the chemokine receptors CCR2-64I and CCR5Delta32 mutations in 318 patients with coronary artery disease (CAD) referred to coronary bypass ..
  23. Krüger B, Schroppel B, Ashkan R, Marder B, Zülke C, Murphy B, et al. A Monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation. J Am Soc Nephrol. 2002;13:2585-9 pubmed
    ..In this respect, increased expression of MCP-1 and the corresponding receptor CCR2 have been demonstrated in renal transplant rejection and coronary artery disease...
  24. Gonzalez P, Alvarez R, Batalla A, Reguero J, Alvarez V, Astudillo A, et al. Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction. Genes Immun. 2001;2:191-5 pubmed
    ..association between myocardial infarction (MI) and two DNA-polymorphisms at the proinflammatory chemokine receptors CCR2 (I64V) and CCR5 (32 bp deletion, (Delta)ccr5), defining if these polymorphisms influence the age for the onset of ..
  25. Ivansson E, Gustavsson I, Magnusson J, Steiner L, Magnusson P, Erlich H, et al. Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancer. Int J Cancer. 2007;121:2451-7 pubmed
    ..We did not find any association for IL-10 -592, or FasL -844, previously reported to be associated with cervical cancer in the Dutch and Chinese populations, respectively. ..
  26. Shi X, Liu S, Xiangyu J, Zhang Y, Huang J, Liu S, et al. Structural analysis of human CCR2b and primate CCR2b by molecular modeling and molecular dynamics simulation. J Mol Model. 2002;8:217-22 pubmed
    b>CCR2b, a chemokine receptor for MCP-1, -2, -3, -4, plays an important role in a variety of diseases involving infection, inflammation, and/or injury, as well as being a coreceptor for HIV-1 infection...
  27. Wang F, Hong W, Cao Y, Liu M, Jin L, Hu L, et al. Population survey of CCR5 delta32, CCR5 m303, CCR2b 64I, and SDF1 3'A allele frequencies in indigenous Chinese healthy individuals, and in HIV-1-infected and HIV-1-uninfected individuals in HIV-1 risk groups. J Acquir Immune Defic Syndr. 2003;32:124-30 pubmed
    ..ethnic groups the frequencies of the chemokine (SDF1 3'A) and chemokine receptors (CCR5 delta32, CCR5 m303, and CCR2b 64I) HIV-1/AIDS restriction alleles...
  28. Ko J, Yun C, Lee J, Kim J, Kim I. p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells. Exp Mol Med. 2007;39:129-38 pubmed
    ..We have previously demonstrated that 9CRA increases expression of chemokine receptors CCR1 and CCR2 in human monocytes...
  29. Charo I, Myers S, Herman A, Franci C, Connolly A, Coughlin S. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A. 1994;91:2752-6 pubmed
    ..The identification of the MCP-1 receptor and cloning of two distinct isoforms provide powerful tools for understanding the specificity and signaling mechanisms of this important chemokine. ..
  30. Ma L, Marmor M, Zhong P, Ewane L, Su B, Nyambi P. Distribution of CCR2-64I and SDF1-3'A alleles and HIV status in 7 ethnic populations of Cameroon. J Acquir Immune Defic Syndr. 2005;40:89-95 pubmed
    ..We report the allelic frequencies of the AIDS-related polymorphisms CCR2-64I, SDF1-3'A, and CCR5-Delta32 in 321 volunteers from 7 ethnic groups in Cameroon...
  31. Ortlepp J, Vesper K, Mevissen V, Schmitz F, Janssens U, Franke A, et al. Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age. J Mol Med (Berl). 2003;81:363-7 pubmed
    ..Chemokines have an important role in inflammation. The CCR2 chemokine receptor mediates leukocyte chemoattraction, which is involved in the pathogenesis of coronary heart ..
  32. Nakajima K, Tanaka Y, Nomiyama T, Ogihara T, Piao L, Sakai K, et al. Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetes. Diabetes. 2002;51:238-42 pubmed
    ..Accordingly, we evaluated the effects of these genotypes on diabetic nephropathy. CCR2 V64I and CCR5 59029 (G/A) were detected by polymerase chain reaction-restriction fragment-length polymorphism in ..
  33. Ioannidis J, Rosenberg P, Goedert J, Ashton L, Benfield T, Buchbinder S, et al. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Ann Intern Med. 2001;135:782-95 pubmed
    ..Data were combined with fixed-effects and random-effects models. Both the CCR5-Delta32 and CCR2-64I alleles were associated with a decreased risk for progression to AIDS (relative hazard among seroconverters, 0...
  34. Knudsen T, Kristiansen T, Katzenstein T, Eugen Olsen J. Adverse effect of the CCR5 promoter -2459A allele on HIV-1 disease progression. J Med Virol. 2001;65:441-4 pubmed
    ..Other human polymorphisms, such as the CCR2 64I and the CCR5 promoter -2459 A/G transition that has been discovered recently, have also been shown to influence ..
  35. Okumoto S, Taniguchi Y, Nakashima A, Masaki T, Ito T, Ogawa T, et al. C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysis. Ther Apher Dial. 2009;13:205-12 pubmed publisher
    ..C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysis. ..
  36. Sezgin I, Koksal B, Bagci G, Kurtulgan H, Ozdemir O. CCR2 polymorphism in chronic renal failure patients requiring long-term hemodialysis. Intern Med. 2011;50:2457-61 pubmed
    ..The CCR2 chemokine receptor mediates leukocyte chemoattraction in the initiation and amplification phase of renal ..
  37. Fang W, Jokar I, Zou A, Lambert D, Dendukuri P, Cheng N. CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms. J Biol Chem. 2012;287:36593-608 pubmed publisher
    ..The G protein-coupled receptor CCR2 was found to be elevated in breast cancers, correlating with CCL2 expression...
  38. Williams D, Calderon T, Lopez L, Carvallo Torres L, Gaskill P, Eugenin E, et al. Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesis. PLoS ONE. 2013;8:e69270 pubmed publisher
    ..This exuberant transmigration of HIV infected monocytes was due, at least in part, to increased CCR2 and significantly heightened sensitivity to CCL2...
  39. Coelho A, Matos A, Catarino R, Pinto D, Pereira D, Lopes C, et al. Protective role of the polymorphism CCR2-64I in the progression from squamous intraepithelial lesions to invasive cervical carcinoma. Gynecol Oncol. 2005;96:760-4 pubmed
    ..The aim of this study was to explore the association of the CCR2-64I polymorphism with the risk of developing invasive cervical cancer (ICC) from squamous intraepithelial lesions (..
  40. Valdes A, Wolfe M, O Brien E, Spurr N, Gefter W, Rut A, et al. Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcification. Arterioscler Thromb Vasc Biol. 2002;22:1924-8 pubmed
    ..have shown that genetic disruption of monocyte chemotactic protein-1 or its receptor, the C-C chemokine receptor 2 (CCR2), inhibits atherosclerosis, but few data exist in humans to suggest that the monocyte chemotactic protein-1-CCR2 ..
  41. Lathey J, Tierney C, Chang S, D Aquila R, Bettendorf D, Alexander H, et al. Associations of CCR5, CCR2, and stromal cell-derived factor 1 genotypes with human immunodeficiency virus disease progression in patients receiving nucleoside therapy. J Infect Dis. 2001;184:1402-11 pubmed
    Genotype data for CCR5, CCR2, and stromal cell-derived factor 1 (SDF-1) were obtained from 354 human immunodeficiency virus type 1 (HIV-1)-positive subjects who were being treated with nucleosides...
  42. Verma R, Gupta R, Singh K, Bhasin R, Anand Shukla A, Chauhan S, et al. Distribution of CCR5delta32, CCR2-64I and SDF1-3'A and plasma levels of SDF-1 in HIV-1 seronegative North Indians. J Clin Virol. 2007;38:198-203 pubmed
    ..Mutations in genes encoding chemokine receptors and their ligands, viz., CCR5delta32, CCR2-64I and SDF1-3'A are implicated to have protective effects against HIV-1 infection and/or disease progression...
  43. Aragay A, Mellado M, Frade J, Martin A, Jimenez Sainz M, Martinez A C, et al. Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. Proc Natl Acad Sci U S A. 1998;95:2985-90 pubmed
    ..Calcium flux responses to MCP-1 in HEK293 cells expressing the CCR2B receptor were also markedly reduced upon cotransfection with GRK2 or the homologous kinase GRK3...
  44. Mulherin S, O Brien T, Ioannidis J, Goedert J, Buchbinder S, Coutinho R, et al. Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection. AIDS. 2003;17:377-87 pubmed
    To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression...
  45. Soto Sánchez J, Santos Juanes J, Coto Segura P, Coto E, Diaz M, Rodriguez I, et al. Genetic variation at the CCR5/CCR2 gene cluster and risk of psoriasis and psoriatic arthritis. Cytokine. 2010;50:114-6 pubmed publisher
    ..Our objective was to examine the association between Ps and three polymorphisms at the chemokine receptors CCR5 and CCR2.
  46. Ogilvie P, Bardi G, Clark Lewis I, Baggiolini M, Uguccioni M. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood. 2001;97:1920-4 pubmed
    ..This study shows that eotaxin also interacts with CCR2 and CCR5 and can, thus, affect the responses of monocytes, which express both receptors...
  47. Lundien M, Mohammed K, Nasreen N, Tepper R, Hardwick J, Sanders K, et al. Induction of MCP-1 expression in airway epithelial cells: role of CCR2 receptor in airway epithelial injury. J Clin Immunol. 2002;22:144-52 pubmed
    ..BECs (BEAS-2B from ATCC) were utilized in this study. MCP-1 interacts with CCR2B receptor (CCR2B), resulting in cell proliferation, haptotaxis, and healing of the monolayer...
  48. Smith M, Dean M, Carrington M, Winkler C, Huttley G, Lomb D, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City C. Science. 1997;277:959-65 pubmed
    ..A mutation (CCR2-64I) within the first transmembrane region of the CCR2 chemokine and HIV-1 receptor gene is described that occurred ..
  49. Despriet D, Bergen A, Merriam J, Zernant J, Barile G, Smith R, et al. Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2008;49:364-71 pubmed publisher
    To determine whether variants in the candidate genes TLR4, CCL2, and CCR2 are associated with age-related macular degeneration (AMD)...
  50. Hoffmann S, Park J, Jacobson L, Muehrer R, Lorentzen D, Kleiner D, et al. Donor genomics influence graft events: the effect of donor polymorphisms on acute rejection and chronic allograft nephropathy. Kidney Int. 2004;66:1686-93 pubmed
    ..IL)-2, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, TGF-beta, interferon (IFN)-gamma] and chemokine (CCR2, CCR5) polymorphisms...
  51. Puissant B, Roubinet F, Massip P, Sandres Saune K, Apoil P, Abbal M, et al. Analysis of CCR5, CCR2, CX3CR1, and SDF1 polymorphisms in HIV-positive treated patients: impact on response to HAART and on peripheral T lymphocyte counts. AIDS Res Hum Retroviruses. 2006;22:153-62 pubmed
    ..and RANTES, regulated on activation, normal T cell expressed and secreted) and chemokine-receptor genes (CCR5, CCR2, CX(3)CR1) were shown to be associated with sensitivity to HIV infection and untreated HIV disease progression, ..
  52. Tang J, Shelton B, Makhatadze N, Zhang Y, Schaen M, Louie L, et al. Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression. J Virol. 2002;76:662-72 pubmed
    At the CC (beta) chemokine receptor 2 (CCR2) and CCR5 loci, combinations of common single-nucleotide polymorphisms (SNPs) and a 32-bp deletion (Delta32) form nine stable haplotypes (designated A through G*2)...
  53. Ding D, Liu S, Zhu H. Association between the CCR2-Val64Ile polymorphism and susceptibility to HIV-1 infection: a meta-analysis. Mol Med Rep. 2011;4:181-6 pubmed publisher
    Several studies have investigated whether the CCR2-Val64Ile polymorphism affects susceptibility to human immune deficiency virus type-1 (HIV-1), with inconclusive results...
  54. Volpe S, Cameroni E, Moepps B, Thelen S, Apuzzo T, Thelen M. CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS ONE. 2012;7:e37208 pubmed publisher
    ..Uptake of the fluorescent agonist was used as indirect measure to follow the endogenous receptor CCR2 expressed on primary human monocytes...
  55. Conductier G, Blondeau N, Guyon A, Nahon J, Rovere C. The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. J Neuroimmunol. 2010;224:93-100 pubmed
    ..This review will focus on the current knowledge about one of the MCPs, CCL2, and its cognate receptor, CCR2, both expressed in physiological conditions and during neurodegenerative diseases.
  56. Daugherty B, Springer M. The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. Genomics. 1997;41:294-5 pubmed