Gene Symbol: CCR1
Description: C-C motif chemokine receptor 1
Alias: CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, LD78 receptor, MIP-1alpha-R, RANTES receptor, RANTES-R, chemokine (C-C motif) receptor 1, macrophage inflammatory protein 1-alpha receptor
Species: human
Products:     CCR1

Top Publications

  1. Kościuczuk E, Lisowski P, Jarczak J, Majewska A, Rzewuska M, Zwierzchowski L, et al. Transcriptome profiling of Staphylococci-infected cow mammary gland parenchyma. BMC Vet Res. 2017;13:161 pubmed publisher
    ..gland immune response for use in Marker Assisted Selection (MAS): chemokine signaling pathway (CCL2, CXCL5, HCK, CCR1), cell adhesion molecules (CAMs) pathway (BOLA-DQA2, BOLA-DQA1, F11R, ITGAL, CD86), antigen processing and ..
  2. Fader K, Nault R, Ammendolia D, Harkema J, Williams K, Crawford R, et al. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice. Toxicol Sci. 2015;148:567-80 pubmed publisher
    ..expression of MHC class II genes, as well as chemokines and chemokine receptors involved in macrophage recruitment (Ccr1, Ccr5, Ccl5, Cx3cr1), consistent with hepatic F4/80 labeling and macrophage infiltration into the liver...
  3. Aissa A, Amaral C, Venâncio V, Machado C, Hernandes L, Santos P, et al. Methionine-supplemented diet affects the expression of cardiovascular disease-related genes and increases inflammatory cytokines in mice heart and liver. J Toxicol Environ Health A. 2017;80:1116-1128 pubmed publisher
    ..expression of the genes Apob, Ctgf, Serpinb2, Spp1, Il1b, and Sell, but elevated expression of Thbs4, Tgfb2, Ccr1, and Vegfa...
  4. Robertson R, Guihéneuf F, Bahar B, Schmid M, Stengel D, Fitzgerald G, et al. The Anti-Inflammatory Effect of Algae-Derived Lipid Extracts on Lipopolysaccharide (LPS)-Stimulated Human THP-1 Macrophages. Mar Drugs. 2015;13:5402-24 pubmed publisher
    ..of the expression of 14 pro-inflammatory genes (TLR1, TLR2, TLR4, TLR8, TRAF5, TRAF6, TNFSF18, IL6R, IL23, CCR1, CCR4, CCL17, STAT3, MAP3K1) by the lipid extracts...
  5. Lu L, Zhang X, Zhang M, Zhang H, Liao L, Yang T, et al. RANTES and SDF-1 Are Keys in Cell-based Therapy of TMJ Osteoarthritis. J Dent Res. 2015;94:1601-9 pubmed publisher
    ..were impaired by the inhibitors of C-X-C chemokine receptor type 4 (CXCR4) and C-C chemokine receptor type 1 (CCR1), which are the receptors of SDF-1 and RANTES, respectively...
  6. Blin M, Bachelier R, Fallague K, Moussouni K, Aurrand Lions M, Fernandez S, et al. CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment. J Mol Cell Cardiol. 2019;130:76-87 pubmed publisher
    ..Finally, Maraviroc, a RANTES receptor antagonist, was able to reduce atherosclerotic lesions and neutrophilia in CD146-deficient mice to the same ..
  7. José R, Williams A, Sulikowski M, Brealey D, Brown J, Chambers R. Regulation of neutrophilic inflammation in lung injury induced by community-acquired pneumonia. Lancet. 2015;385 Suppl 1:S52 pubmed publisher
    ..on neutrophils from BALF compared with blood (median difference in MFI 1337, p=0·0020) and that of CXCR2, CCR1, CCR2, and CCR3 was increased (125·5, p=0·0020; 335·1, p=0·0020; 116, p=0·0068; and 275, p=0·0020;..
  8. Pattappa G, Peroglio M, Sakai D, Mochida J, Benneker L, Alini M, et al. CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture. Eur Cell Mater. 2014;27:124-36; discussion 136 pubmed
    ..MSCs showed a significant increase in mRNA expression of the CCL5 receptors, CCR1 and CCR4, upon culture in degenerative media...
  9. Zhao H, Kalish F, Wong R, Stevenson D. Infiltration of myeloid cells in the pregnant uterus is affected by heme oxygenase-1. J Leukoc Biol. 2017;101:217-226 pubmed publisher
    ..Csf1, Csf3), chemokines (Ccl1, Ccl2, Ccl6, Ccl8, Ccl11, Ccl12, Cxcl4, Cxcl9, Cxcl12), and their receptors (Ccr1, Ccr2, Ccr3, Ccr5) were also reduced significantly in Het compared with pregnant WT uteri...

More Information

Publications102 found, 100 shown here

  1. Gouwy M, De Buck M, Pörtner N, Opdenakker G, Proost P, Struyf S, et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. Eur J Immunol. 2015;45:101-12 pubmed publisher
    ..exogenous MIP-1α/CCL3, neutralizing anti-MIP-1α/CCL3 antibody, or a combination of CC chemokine receptor 1 (CCR1) and CCR5 antagonists, indicating that this endogenously produced CC chemokine was indirectly contributing to SAA1-..
  2. de Vries T, Andreotta S, Loos B, Nicu E. Genes Critical for Developing Periodontitis: Lessons from Mouse Models. Front Immunol. 2017;8:1395 pubmed publisher
    ..are described that protect the mice from periodontitis: the SCID mouse, and mice lacking Tlr2/Tlr4, the Ccr1/Ccr5, the Tnf-? receptor p55, and Cathepsin K by attenuating the inflammatory reaction and ..
  3. Imgenberg Kreuz J, Sandling J, Björk A, Nordlund J, Kvarnström M, Eloranta M, et al. Transcription profiling of peripheral B cells in antibody-positive primary Sjögren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature. Scand J Immunol. 2018;87:e12662 pubmed publisher
    ..genes were CX3CR1, encoding the fractalkine receptor involved in regulation of B-cell malignancies, CCL5/RANTES and CCR1. Increased expression of several members of the TNF superfamily was also identified; TNFSF4/Ox40L, TNFSF10/TRAIL, ..
  4. Gao Y, Zhou Z, Lu S, Huang X, Zhang C, Jiang R, et al. Chemokine CCL15 Mediates Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Hepatocellular Carcinoma. Stem Cells. 2016;34:1112-22 pubmed publisher chemotaxis of human MSCs (hMSCs) toward HCC in vitro and that this chemotactic effect of CCL15 is mediated via CCR1 receptors on hMSCs...
  5. Ho K, Chen P, Hsi E, Shih C, Chang W, Cheng C, et al. Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis. Sci Rep. 2017;7:732 pubmed publisher
    ..The C-C chemokine receptor type 1 (CCR1) and interleukin (IL)-1b demonstrated inverse correlations with miR-181d levels and associations with patient ..
  6. Lima I, Silva J, Rodrigues L, Madureira D, Fonseca A, Garlet G, et al. Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling. Bone. 2017;101:113-122 pubmed publisher
    ..OTM resulted in augmented expression of CC chemokines and receptors CCR5 and CCR1 in periodontium, which was higher in ACKR2-/- than WT mice...
  7. Molica F, Matter C, Burger F, Pelli G, Lenglet S, Zimmer A, et al. Cannabinoid receptor CB2 protects against balloon-induced neointima formation. Am J Physiol Heart Circ Physiol. 2012;302:H1064-74 pubmed publisher
    ..adherence and migration compared with WT cells and elevated mRNA levels of adhesion molecules, chemokine receptors CCR1 and 5, and chemokine CCL2...
  8. Kim H, Ryu K, Ko Y, Kim H, Kim S, Kim W, et al. Macrophage inflammatory protein 1 alpha (MIP-1α) may be associated with poor outcome in patients with extranodal NK/T-cell lymphoma. Hematol Oncol. 2017;35:310-316 pubmed publisher
    ..002). An in vitro study with patient-derived ENKTL tumour cells showed the expression of CCR1 and CCR5 on the surface of tumour cells (28% and 14%, respectively) , and the addition of MIP-1α to the culture ..
  9. Pais R, Zietek T, Hauner H, Daniel H, Skurk T. RANTES (CCL5) reduces glucose-dependent secretion of glucagon-like peptides 1 and 2 and impairs glucose-induced insulin secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2014;307:G330-7 pubmed publisher
    ..These data show that RANTES is involved in altered secretion of glucagon-like peptide hormones most probably acting through SGLT1, and our study identifies the RANTES-receptor CCR1 as a potential target in diabetes therapy.
  10. Hoos M, Vitek M, Ridnour L, Wilson J, Jansen M, Everhart A, et al. The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment. Mol Neurodegener. 2014;9:50 pubmed publisher
    ..anti-inflammatory and chemokine genes were not significantly different with the exception of increased TNFα and Ccr1 mRNA expression in the HuNOS2tg/mNos2-/- mice compared to WT or mNos2-/- mice...
  11. Blázquez Prieto J, López Alonso I, Amado Rodríguez L, Batalla Solís E, González López A, Albaiceta G. Exposure to mechanical ventilation promotes tolerance to ventilator-induced lung injury by Ccl3 downregulation. Am J Physiol Lung Cell Mol Physiol. 2015;309:L847-56 pubmed publisher
    ..In separate, nonconditioned animals, treatment with BX471, a specific blocker of CCR1 (the main receptor for MIP-1α), decreased lung damage and neutrophilic infiltration caused by high-pressure ..
  12. Chen S, Tang J, Cheng J, Li J, Jin C, Li X, et al. Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling. Oncotarget. 2015;6:37012-27 pubmed publisher
    ..mouse testes showed alterations in chemokine signaling factors, including Cxcl12, Ccl3, Cxcr4 (CXCL12 receptor), Ccr1 (CCL3 receptor), Ccl9, Xcl1 and Ccrl2...
  13. Kogelman L, Cirera S, Zhernakova D, Fredholm M, Franke L, Kadarmideen H. Identification of co-expression gene networks, regulatory genes and pathways for obesity based on adipose tissue RNA Sequencing in a porcine model. BMC Med Genomics. 2014;7:57 pubmed publisher
    ..regulator genes, using confident scores, for the WGCNA module which was associated with osteoclast differentiation: CCR1, MSR1 and SI1 (probability scores respectively 95.30, 62.28, and 34.58)...
  14. Scarborough J, Paul J, Spencer J. Evolution of the ability to modulate host chemokine networks via gene duplication in human cytomegalovirus (HCMV). Infect Genet Evol. 2017;51:46-53 pubmed publisher
    ..diverged significantly, highlighted by the fact that pUS27 currently exhibits greater sequence similarity to human CCR1. While the evolutionary advantage of the gene duplication and neofunctionalization event remains unclear, the US27 ..
  15. Lim J, Ryu D, Lee S, Park G, Min C. Mesenchymal Stem Cells (MSCs) Attenuate Cutaneous Sclerodermatous Graft-Versus-Host Disease (Scl-GVHD) through Inhibition of Immune Cell Infiltration in a Mouse Model. J Invest Dermatol. 2017;137:1895-1904 pubmed publisher
    ..of immune effector cells into skin via down-regulation of CCR4 and CCR8 expression on CD4+ T cells and CCR1 on CD11b+ monocyte/macrophages...
  16. Chen S, Liu Y. Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling. Reproduction. 2015;149:R159-67 pubmed publisher
    ..transcription factors and signaling pathways (GDNF-RET-GFRA1 signaling, FGF2-MAP2K1 signaling, CXCL12-CXCR4 signaling, CCL9-CCR1 signaling, FSH-nociceptin/OPRL1, retinoic acid/FSH-NRG/ERBB4, and AR/RB-ARID4A/ARID4B) are also addressed.
  17. Wang Y, Gao A, Zhao H, Lu P, Cheng H, Dong F, et al. Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1?/CCL3. Leukemia. 2016;30:1897-908 pubmed publisher
    ..Administration of the CCR1 antagonist partially recovered the yield of erythroid colonies in the presence of CCL3 or leukemic BM plasma...
  18. Lee W, Do J, Park C, Kim J, Chung H, Kim K, et al. Identification of Putative Biomarkers for the Early Stage of Porcine Spermatogonial Stem Cells Using Next-Generation Sequencing. PLoS ONE. 2016;11:e0147298 pubmed publisher
    ..metallopeptidase 9 (MMP9), matrix metallopeptidase 1 (MMP1), glutathione peroxidase 1 (GPX1), chemokine receptor 1 (CCR1), insulin-like growth factor binding protein 3 (IGFBP3), CD14, CD209, and Kruppel-like factor 9 (KLF9)...
  19. Lindholm Perry A, Kuehn L, McDaneld T, Miles J, Workman A, Chitko McKown C, et al. Complete blood count data and leukocyte expression of cytokine genes and cytokine receptor genes associated with bovine respiratory disease in calves. BMC Res Notes. 2018;11:786 pubmed publisher
    ..Expression of CCL16, CXCR1, CCR1 was increased in BRD positive animals compared to controls (P-corrected < 0.1)...
  20. Herbin O, Regelmann A, Ramkhelawon B, Weinstein E, Moore K, Alexandropoulos K. Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1. Arterioscler Thromb Vasc Biol. 2016;36:1791-801 pubmed publisher
    ..In contrast, Chat-H was dispensable for CX3CL1 and CCR1/CCR5-dependent migration of monocytes...
  21. Yabluchanskiy A, Ma Y, DeLeon Pennell K, Altara R, Halade G, Voorhees A, et al. Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. J Gerontol A Biol Sci Med Sci. 2016;71:475-83 pubmed publisher
    ..05) and seven anti-inflammatory genes (CCL1, CCL6, CCR1, IL11, IL1r2, IL8rb, and Mif; all p < .05)...
  22. Hwaiz R, Rahman M, Syk I, Zhang E, Thorlacius H. Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury. J Leukoc Biol. 2015;97:975-984 pubmed publisher
    ..Isolated alveolar macrophages expressed significant levels of the CCL5 receptors CCR1 and CCR5. In addition, CCL5 triggered significant secretion of CXCL2 from isolated alveolar macrophages...
  23. Kim Y, Lee J. Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression. Cell Immunol. 2017;316:11-20 pubmed publisher
    ..The inhibitory activities of HDACis were found to be caused by reduction of CCR1 expression on the cell surface, and by the inhibition of phosphorylation of p38 mitogen-activated protein kinase (..
  24. Fulkerson P, Schollaert K, Bouffi C, Rothenberg M. IL-5 triggers a cooperative cytokine network that promotes eosinophil precursor maturation. J Immunol. 2014;193:4043-52 pubmed publisher
    ..In contrast, CCL3, an eosinophil precursor-produced chemokine that signals through CCR1, promotes terminal differentiation of CCR1-positive eosinophil precursors in the absence of IL-5, highlighting an ..
  25. Miyabe Y, Miyabe C, Murooka T, Kim E, Newton G, Kim N, et al. Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis. Sci Immunol. 2017;2: pubmed publisher
    ..The chemokine receptor CCR1 promoted neutrophil crawling on the joint endothelium while CXCR2 amplified late neutrophil recruitment and ..
  26. Barrière Y, Courtial A, Chateigner Boutin A, Denoue D, Grima Pettenati J. Breeding maize for silage and biofuel production, an illustration of a step forward with the genome sequence. Plant Sci. 2016;242:310-329 pubmed publisher
    ..were less frequent with genes involved in monolignol biosynthesis, and found only with the C4H2, CCoAOMT5, and CCR1 genes. Close colocalizations were also infrequent with genes involved in cell wall feruloylation and cross-linkages...
  27. Guimarães F, Sales Campos H, Nardini V, da Costa T, Fonseca M, Júnior V, et al. The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing. Clin Immunol. 2018;190:74-83 pubmed publisher
    ..The 5-LO-/- wounds also had diminished TNF-α, CCL11, CCL7, CCL2, CXCL9, CCR1 and CXCR2 mRNA expression in the lesions, besides differential extracellular matrix remodeling...
  28. García Faroldi G, Rönnberg E, Grujic M, Pejler G. Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells. Immun Inflamm Dis. 2017;5:141-150 pubmed publisher
    ..a number of additional genes of those that were upregulated by IgE receptor cross-linking, including IL-3, IL-7R, CCR1, and ADAMTS9. However, BET inhibition was selective, i.e...
  29. Heo S, Noh E, Yoon D, Jo J, Koh S, Baek J, et al. Rosmarinic acid potentiates ATRA-induced macrophage differentiation in acute promyelocytic leukemia NB4 cells. Eur J Pharmacol. 2015;747:36-44 pubmed publisher
    ..Th also had typical expression of C-C chemokine receptor type 1 (CCR1), CCR2, and intercellular adhesion molecule-1 (ICAM-1)...
  30. Lu P, Wang Y, Zheng Y, Dong F, Pang Y, Cheng H, et al. [Macrophage inflammatory protein-1α promotes the growth of acute myeloid leukemia cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:306-11 pubmed publisher
    ..was explored by using the small molecule antagonist for interfering interaction of MIP-1α with its receptor CCR1. The MIP-1α could promote the proliferation and colony formation of AML cells, the blocking MIP-1a could inhibit ..
  31. Bellora F, Dondero A, Corrias M, Casu B, Regis S, Caliendo F, et al. Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages. J Immunol. 2017;199:1516-1525 pubmed publisher
    ..Moreover, TKIs reduced the expression of CXCR3 (in NK cells) and CCR1 (in monocytes)...
  32. Jerônimo M, Barros A, MoritaI V, Alves E, Souza N, Almeida R, et al. Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing. Acta Cir Bras. 2016;31:586-596 pubmed publisher
    ..Topical administration decreased IL-8 and CCR1 expression by wound cells but did not interfere with TNF-? and IL-10 production, ratifying the decrease of ..
  33. Kata D, Földesi I, Fehér L, Hackler L, Puskas L, Gulya K. A novel pleiotropic effect of aspirin: Beneficial regulation of pro- and anti-inflammatory mechanisms in microglial cells. Brain Res Bull. 2017;132:61-74 pubmed publisher
    ..of inflammation-related genes as it downregulated such pro-inflammatory genes as Nos2, Kng1, IL1β, Ptgs2 or Ccr1, while it upregulated some anti-inflammatory genes such as IL10, Csf2, Cxcl1, Ccl5 or Tgfb1...
  34. Shahrara S, Amin M, Woods J, Haines G, Koch A. Chemokine receptor expression and in vivo signaling pathways in the joints of rats with adjuvant-induced arthritis. Arthritis Rheum. 2003;48:3568-83 pubmed
    ..We showed significant up-regulation of CCR1, CCR2, CCR5, and macrophage inflammatory protein 1beta/CCL4 mRNA in AIA on post-adjuvant injection day 18, ..
  35. Sung H, Kim Y, Kang H, Ko J. Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. Exp Mol Med. 2008;40:332-8 pubmed
    ..RNase protection analysis showed that LZIP increased mRNA expression of CCR2 and CCR1 in THP-1 cells. Surface expressions of both CCR2 and CCR1 were also increased by LZIP...
  36. Richter R, Casarosa P, Ständker L, Munch J, Springael J, Nijmeijer S, et al. Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28. J Immunol. 2009;183:1229-37 pubmed publisher
    ..urokinase-type plasminogen activator and plasmin and is a highly active agonist for the chemokine receptors CCR1 and CCR5. In this study, a new CCL14a analog, CCL14a(12-74), was isolated from blood filtrate...
  37. Fox J, Letellier E, Oliphant C, Signoret N. TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes. Blood. 2011;117:1851-60 pubmed publisher
    During innate immune responses, the inflammatory CC chemokine receptors CCR1, CCR2, and CCR5 mediate the recruitment of blood monocytes to infected tissues by promoting cell migration in response to chemokines CCL2-5...
  38. Anderson M, Zhao S, Ai W, Tibshirani R, Levy R, Lossos I, et al. C-C chemokine receptor 1 expression in human hematolymphoid neoplasia. Am J Clin Pathol. 2010;133:473-83 pubmed publisher
    Chemokine receptor 1 (CCR1) is a G protein-coupled receptor that binds to members of the C-C chemokine family...
  39. Pollakis G, Paxton W. Use of (alternative) coreceptors for HIV entry. Curr Opin HIV AIDS. 2012;7:440-9 pubmed publisher
    ..We have summarized the recent findings concerning the multitude of receptors and coreceptors which can interact with HIV-1 and have discussed the consequences for either HIV-1 transmission or disease progression. ..
  40. Kholodnyuk I, Rudevica Z, Leonciks A, Ehlin Henriksson B, Kashuba E. Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines. Virology. 2017;512:1-7 pubmed publisher
    ..Chemokine receptors regulate immune system function. CCR1 and CCR2 share protein sequence similarity and exert responses to multiple chemokines...
  41. Combadiere C, Ahuja S, Van Damme J, Tiffany H, Gao J, Murphy P. Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. J Biol Chem. 1995;270:29671-5 pubmed
    ..alpha (MIP-1 alpha)/regulated on activation, normal T expressed, and secreted protein (RANTES) receptor CC CKR1 (rank order for [Ca2+]i changes = MIP-1 alpha > MCP-3 > RANTES), which is expressed in monocytes > ..
  42. Struyf S, Menten P, Lenaerts J, Put W, D Haese A, De Clercq E, et al. Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. Eur J Immunol. 2001;31:2170-8 pubmed
    ..more efficiently than LD78beta(1 - 70) with [125I] RANTES for binding to the CC chemokine receptors CCR5 and CCR1. Contrary to LD78alpha, LD78beta(1 - 70) at 30 ng/ml efficiently competed with [125I] RANTES for binding to CCR3 ..
  43. Mack M, Pfirstinger J, Weber C, Weber K, Nelson P, Rupp T, et al. Chondroitin sulfate A released from platelets blocks RANTES presentation on cell surfaces and RANTES-dependent firm adhesion of leukocytes. Eur J Immunol. 2002;32:1012-20 pubmed
    ..Taken together, chondroitin sulfate A released from platelets appears to act as an important regulatory molecule for cellular responses to chemokines. ..
  44. Nakamura H, Higashikawa F, Nobukuni Y, Miyagawa K, Endo T, Imai T, et al. Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis. Int Arch Allergy Immunol. 2007;142:329-34 pubmed
    ..We sequenced CCR1, CCR2, CCR3, CCR5, and CCXCR1 using the PCR restriction fragment length polymorphism method in subjects with cedar ..
  45. Lee M, Wong Y. CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galpha(16) signaling cascades. J Leukoc Biol. 2009;86:1319-29 pubmed publisher
    Agonists of CC chemokine receptor CCR1 contribute to the pathogenesis of autoimmune and other inflammatory diseases, possibly via the regulation of the transcription factor NF-kappaB...
  46. Sierra B, Perez A, Garcia G, Aguirre E, Alvarez M, Gonzalez D, et al. Role of CC chemokine receptor 1 and two of its ligands in human dengue infection. Three approaches under the Cuban situation. Microbes Infect. 2014;16:40-50 pubmed publisher
    ..We addressed the role of CCR1 and its ligands CCL3/MIP-1? and CCL5/RANTES in dengue infection using three different approaches: an ex vivo model ..
  47. Conroy M, Galvin K, Kavanagh M, Mongan A, Doyle S, Gilmartin N, et al. CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer. Immunol Cell Biol. 2016;94:531-7 pubmed publisher
  48. Shaw K, Greig N. Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection. Neuroreport. 1999;10:53-6 pubmed
    ..Interestingly, TNF-alpha was able to induce CCR1, CCR3 as well as CXCR1, CXCR2, CXCR4 receptors and Burkitt's lymphoma receptor BLR2...
  49. Proudfoot A, Fritchley S, Borlat F, Shaw J, Vilbois F, Zwahlen C, et al. The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity. J Biol Chem. 2001;276:10620-6 pubmed
    ..The mutants were tested for their integrity by receptor binding assays on CCR1 and CCR5 as well as their ability to induce chemotaxis in vitro...
  50. Vallet S, Pozzi S, Patel K, Vaghela N, Fulciniti M, Veiby P, et al. A novel role for CCL3 (MIP-1?) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function. Leukemia. 2011;25:1174-81 pubmed publisher
    ..CCL3 and its receptors, CCR1 and CCR5, contribute to the development of bone disease in MM by supporting tumor growth and regulating osteoclast (..
  51. Gallo C, Borra R, Rodini C, Nunes F, Sugaya N. CC chemokine ligand 3 and receptors 1 and 5 gene expression in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:93-8 pubmed publisher
    ..this study was to investigate the local and systemic expression of CC-chemokine ligand 3 (CCL3) and its receptors (CCR1 and CCR5) in tissue samples and peripheral blood mononuclear cells of recurrent aphthous stomatitis (RAS) patients...
  52. Kuang Y, Wu Y, Jiang H, Wu D. Selective G protein coupling by C-C chemokine receptors. J Biol Chem. 1996;271:3975-8 pubmed
    ..The commonality of the chemokine receptors in coupling to the Gi-Gbetagamma-PLC beta2 pathway provides a potential target for developing broad spectrum anti-inflammatory drugs. ..
  53. Berkhout T, Gohil J, Gonzalez P, Nicols C, Moores K, Macphee C, et al. Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1). Biochem Pharmacol. 2000;59:591-6 pubmed
    Human CC chemokine receptor 1 (CCR1) has been proposed as a receptor for CKbeta8...
  54. Kantarci O, Morales Y, Ziemer P, Hebrink D, Mahad D, Atkinson E, et al. CCR5Delta32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis. J Neuroimmunol. 2005;169:137-43 pubmed
    ..Infiltrating monocytes in lesions of all patterns co-express CCR1 and CCR5...
  55. Ukani R, Lewis T, Day T, Wu W, Malladi S, Warshakoon H, et al. Potent adjuvantic activity of a CCR1-agonistic bis-quinoline. Bioorg Med Chem Lett. 2012;22:293-5 pubmed publisher
    ..RE-660) was found to have C-C chemokine receptor type 1 (CCR1)-agonistic properties...
  56. Lee M, Chui R, Tam I, Lau A, Wong Y. CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive G?(14/16) signaling and IL-6 release. J Immunol. 2012;189:5266-76 pubmed publisher
    Agonists of CCR1 contribute to hypersensitivity reactions and atherosclerotic lesions, possibly via the regulation of the transcription factor STAT3...
  57. Kato T, Fujita Y, Nakane K, Mizutani K, Terazawa R, Ehara H, et al. CCR1/CCL5 interaction promotes invasion of taxane-resistant PC3 prostate cancer cells by increasing secretion of MMPs 2/9 and by activating ERK and Rac signaling. Cytokine. 2013;64:251-7 pubmed publisher
    ..We investigated the role of the chemokine (C-C motif) receptor 1 (CCR1) and its ligand, chemokine (C-C motif) ligand 5 (CCL5), in taxane-resistant CRPC using paclitaxel-resistant ..
  58. Detheux M, Ständker L, Vakili J, Munch J, Forssmann U, Adermann K, et al. Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties. J Exp Med. 2000;192:1501-8 pubmed
    ..HCC-1[9-74] was a potent agonist of CCR1, CCR3, and CCR5 and promoted calcium flux and chemotaxis of T lymphoblasts, monocytes, and eosinophils...
  59. Ruibal Ares B, Belmonte L, Baré P, Parodi C, Massud I, de Bracco M. HIV-1 infection and chemokine receptor modulation. Curr HIV Res. 2004;2:39-50 pubmed
    ..They could also reflect direct effects of HIV-1 on chemokine-receptor turnover. In this review, the mechanisms of modulation of CXCR4 and CCR5 expression after HIV-1 infection will be discussed. ..
  60. Morrison P, Thomas L, Sharland M, Friedland J. RSV-infected airway epithelial cells cause biphasic up-regulation of CCR1 expression on human monocytes. J Leukoc Biol. 2007;81:1487-95 pubmed
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    Investigators have suggested that the chemokine receptor CCR1 plays a role in multiple myeloma...
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    ..Results of this study demonstrated that CCL23 and its receptor, chemokine (C-C motif) receptor type 1 (CCR1), are up-regulated in porcine endometria during pregnancy...
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    ..Type 1 diabetes and celiac disease share HLA-DQ, IL2-IL21, CCR3 and SH2B3 risk regions. Thus, this extensive genome-wide association follow-up study has identified additional celiac disease risk variants in relevant biological pathways. ..
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    Deep infiltrating endometriosis (DIE) is typically characterized by multifocal locations. It has been shown that CCR1, combined highly with RANTES, contributes to the enhanced recruitment of inflammatory cells at endometriotic sites...