CCNY

Summary

Gene Symbol: CCNY
Description: cyclin Y
Alias: C10orf9, CBCP1, CCNX, CFP1, cyclin-Y, cyc-Y, cyclin box protein 1, cyclin fold protein 1, cyclin-X, cyclin-box carrying protein 1
Species: human
Products:     CCNY

Top Publications

  1. Mikolcevic P, Rainer J, Geley S. Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKs. Cell Cycle. 2012;11:3758-68 pubmed publisher
    ..PCTAIREs are activated by cyclin Y (CCNY), a highly conserved single cyclin fold protein...
  2. Jiang M, Gao Y, Yang T, Zhu X, Chen J. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. FEBS Lett. 2009;583:2171-8 pubmed publisher
    A novel cyclin, CCNY, was identified as a PFTK1 interacting protein in a yeast two-hybrid screen...
  3. Mikolcevic P, Sigl R, Rauch V, Hess M, Pfaller K, Barisic M, et al. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol Cell Biol. 2012;32:868-79 pubmed publisher
    ..Here, we report that CDK16 is activated by membrane-associated cyclin Y (CCNY)...
  4. Ma L, Gu M, Teng Y, Li W. Establishing a detection method for CCNY: a potentially significant clinical investigative marker in NSCLC patients. Onco Targets Ther. 2019;12:921-932 pubmed publisher
    b>CCNY, a novel cyclin family member, plays an increasingly important role in the progression of tumor invasion and metastasis, including lung cancer...
  5. Endo A, Toki S. Targeted Mutagenesis Using FnCpf1 in Tobacco. Methods Mol Biol. 2019;1917:269-281 pubmed publisher
    ..Several papers have shown that Cpf1 could be a versatile tool in plant genome engineering. Cfp1 from Francisella novicida (FnCpf1) recognizes TTN as its protospacer adjacent motif (PAM)...
  6. Moreau P, Cournac A, Palumbo G, Marbouty M, Mortaza S, Thierry A, et al. Tridimensional infiltration of DNA viruses into the host genome shows preferential contact with active chromatin. Nat Commun. 2018;9:4268 pubmed publisher
    ..HBV contacts preferentially CpG islands (CGIs) enriched in Cfp1 a factor required for its transcription...
  7. Endo A, Toki S. FnCpf1-Mediated Targeted Mutagenesis in Plants. Methods Mol Biol. 2018;1795:223-239 pubmed publisher
    ..Several papers have shown clearly that Cpf1 could be a versatile SSN in plant genome engineering. Cfp1 from Francisella novicida (FnCpf1) recognizes TTN as its protospacer adjacent motif (PAM)...
  8. van de Lagemaat L, Flenley M, Lynch M, Garrick D, Tomlinson S, Kranc K, et al. CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands. Epigenetics Chromatin. 2018;11:59 pubmed publisher
    ..The CxxC zinc finger protein 1 (CFP1, also known as CGBP) is a subunit of the TrxG SET1 protein complex, a major catalyst of trimethylation of H3K4 (..
  9. Wojcik G, Marie C, Abhyankar M, Yoshida N, Watanabe K, Mentzer A, et al. Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease. MBio. 2018;9: pubmed publisher
    ..histolytica infection. An intergenic insertion between CREM and CCNY (rs58000832) achieved genome-wide significance (P value from meta-analysis [Pmeta] = 6...

More Information

Publications48

  1. Chen R, Stempor P, Down T, Zeiser E, Feuer S, Ahringer J. Extreme HOT regions are CpG-dense promoters in C. elegans and humans. Genome Res. 2014;24:1138-46 pubmed publisher
    ..Nonmethylated CG dinucleotides are recognized by CXXC finger protein 1 (CXXC1, also known as CFP1), which recruits SETD1A (also known as Set1) methyltransferase for trimethylation of histone H3 lysine 4, an active ..
  2. Thomson J, Skene P, Selfridge J, Clouaire T, Guy J, Webb S, et al. CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature. 2010;464:1082-6 pubmed publisher
    ..By performing a search for proteins that are common to all CGIs, here we show high enrichment for Cfp1, which selectively binds to non-methylated CpGs in vitro...
  3. Clouaire T, Webb S, Skene P, Illingworth R, Kerr A, Andrews R, et al. Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells. Genes Dev. 2012;26:1714-28 pubmed publisher
    ..The Set1 complex is responsible for most somatic H3K4me3 and contains the conserved subunit CxxC finger protein 1 (Cfp1), which binds to unmethylated CpGs and links H3K4me3 with CpG islands (CGIs)...
  4. Chun K, Li B, Dobrota E, Tate C, Lee J, Khan S, et al. The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis. PLoS ONE. 2014;9:e113745 pubmed publisher
    CXXC finger protein 1 (Cfp1), encoded by the Cxxc1 gene, binds to DNA sequences containing an unmethylated CpG dinucleotide and is an epigenetic regulator of both cytosine and histone methylation...
  5. Clouaire T, Webb S, Bird A. Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells. Genome Biol. 2014;15:451 pubmed publisher
    ..The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in targeting the Set1 complex to CpG islands in mammals...
  6. Koder S, Repnik K, Ferkolj I, Pernat C, Skok P, Weersma R, et al. Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients. Pharmacogenomics. 2015;16:191-204 pubmed publisher
    ..Additional SNPs in 7 out of 31 tested CD-associated genes (PTGER4, CASP9, IL27, C11orf30, CCNY, IL13, NR1I2) showed suggestive association with ADA response...
  7. Sha Q, Dai X, Jiang J, Yu C, Jiang Y, Liu J, et al. CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes. Nat Commun. 2018;9:3477 pubmed publisher
    ..CxxC-finger protein-1 (CFP1) is a major mediator of H3K4 trimethylation in mouse oocytes...
  8. Cheray M, Nadaradjane A, Bonnet P, Routier S, Vallette F, Cartron P. Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness. Epigenomics. 2014;6:267-75 pubmed publisher
    ..Our study demonstrates that the disruption of DNMT1/CFP1-including complexes increases the efficiency of chemotherapeutic treatment on established tumors in mice...
  9. Joe I, Kim J, Kim H, Hong J, Kim M, Park M. Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons. PLoS ONE. 2017;12:e0172547 pubmed publisher
    b>Cyclin Y (CCNY), which is a cyclin protein known to play a role in cell division, is unexpectedly and thus interestingly expressed in non-proliferating neuronal cells...
  10. Oliveira H, Pinto G, Oliveira A, Oliveira C, Faustino M, Briers Y, et al. Characterization and genome sequencing of a Citrobacter freundii phage CfP1 harboring a lysin active against multidrug-resistant isolates. Appl Microbiol Biotechnol. 2016;100:10543-10553 pubmed
    ..Its morphology, activity spectrum, burst size, and biophysical stability spectrum were determined. CfP1 specifically infects C...
  11. Moe B, Yuan C, Li J, Du H, Gabos S, Le X, et al. Real-Time Cell-Electronic Sensing of Coal Fly Ash Particulate Matter for Toxicity-Based Air Quality Monitoring. Chem Res Toxicol. 2016;29:972-80 pubmed publisher
    ..5 ? PM10-2.5 ? PM10) and the sampling location (CFP2 > CFP1 ? CFP3)...
  12. Mahadevan J, Skalnik D. Efficient differentiation of murine embryonic stem cells requires the binding of CXXC finger protein 1 to DNA or methylated histone H3-Lys4. Gene. 2016;594:1-9 pubmed publisher
    Mammalian CXXC finger protein 1 (Cfp1) is a DNA-binding protein that is a component of the Setd1 histone methyltransferase complexes and is a critical epigenetic regulator of both histone and cytosine methylation...
  13. An W, Zhang Z, Zeng L, Yang Y, Zhu X, Wu J. Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production. PLoS ONE. 2015;10:e0132721 pubmed publisher
    A new member of the cyclin family cyclin Y (CCNY) is involved in the regulation of various physiological processes. In this study, the role of CCNY in energy metabolism was characterized...
  14. Stevens L, Hoskins S. The CREATE Strategy for Intensive Analysis of Primary Literature Can Be Used Effectively by Newly Trained Faculty to Produce Multiple Gains in Diverse Students. CBE Life Sci Educ. 2014;13:224-42 pubmed publisher
    ..CREATE was developed and piloted at the City College of New York (CCNY), a 4-yr, minority-serving institution, with both upper-level biology majors and first-year students interested in ..
  15. Lee Y, Li Y, Su C, Chiao C, Lin I, Hsu M. MAF1 represses CDKN1A through a Pol III-dependent mechanism. elife. 2015;4:e06283 pubmed publisher
    ..analysis after MAF1 knockdown indicated enhanced binding of Pol III and BRF1, as well as of CFP1, p300, and PCAF, which are factors that mediate active histone marks, along with the binding of TATA binding ..
  16. Cho E, Kim D, Hur Y, Whitcomb D, Regan P, Hong J, et al. Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP. Sci Rep. 2015;5:12624 pubmed publisher
    b>Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division...
  17. Zi Z, Zhang Z, Li Q, An W, Zeng L, Gao D, et al. CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse. PLoS Genet. 2015;11:e1005485 pubmed publisher
    b>Cyclin Y-like 1 (Ccnyl1) is a newly-identified member of the cyclin family and is highly similar in protein sequences to Cyclin Y (Ccny). However, the function of Ccnyl1 is poorly characterized in any organism...
  18. Mao C, Wang X, Liu Y, Wang M, Yan B, Jiang Y, et al. A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53. Cancer Res. 2018;78:3484-3496 pubmed publisher
    ..Chromatin remodeling proteins LSH and Cfp1 silenced or increased P53RRA expression, respectively...
  19. Zeng L, Cai C, Li S, Wang W, Li Y, Chen J, et al. Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells. PLoS Genet. 2016;12:e1006055 pubmed publisher
    b>Cyclin Y family can enhance Wnt/?-catenin signaling in mitosis. Their physiological roles in mammalian development are yet unknown...
  20. Li X, Wang X, Liu G, Li R, Yu L. Identification and characterization of cyclin X which activates transcriptional activities of c-Myc. Mol Biol Rep. 2009;36:97-103 pubmed
    ..This putative cyclin, designated cyclin X, contains a typical cyclin box...
  21. Davidson G, Shen J, Huang Y, Su Y, Karaulanov E, Bartscherer K, et al. Cell cycle control of wnt receptor activation. Dev Cell. 2009;17:788-99 pubmed publisher
    ..L63 and its vertebrate homolog PFTK are regulated by the membrane tethered G2/M Cyclin, Cyclin Y, which mediates binding to and phosphorylation of LRP6...
  22. Brown D, Di Cerbo V, Feldmann A, Ahn J, Ito S, Blackledge N, et al. The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin. Cell Rep. 2017;20:2313-2327 pubmed publisher
    ..genomics, we discover that the vertebrate SET1 complex is targeted to actively transcribed gene promoters through CFP1, which engages in a form of multivalent chromatin reading that involves recognition of non-methylated DNA and ..
  23. Vazquez M, Marte O, Barba J, Hubbard K. An Approach to Integrating Health Disparities within Undergraduate Biomedical Engineering Education. Ann Biomed Eng. 2017;45:2703-2715 pubmed publisher
    ..Here, the Department of Biomedical Engineering at The City College of New York (CCNY) has leveraged its historical mission of access-and-excellence to integrate the study of health disparities into ..
  24. Yu C, Fan X, Sha Q, Wang H, Li B, Dai X, et al. CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep. 2017;20:1161-1172 pubmed publisher
    ..To examine the in vivo function of H3K4me3 in the absence of DNA replication, we deleted CXXC finger protein 1 (CFP1), the DNA-binding subunit of the SETD1 histone H3K4 methyltransferase, in developing oocytes...
  25. Franke A, Balschun T, Karlsen T, Hedderich J, May S, Lu T, et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet. 2008;40:713-5 pubmed publisher
    ..Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ..
  26. Anderson C, Massey D, Barrett J, Prescott N, Tremelling M, Fisher S, et al. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship. Gastroenterology. 2009;136:523-9.e3 pubmed publisher
    ..ECM1 variation was not associated with CD. Collectively, these data help define the genetic relationship between CD and UC and characterize common, as well as disease-specific mechanisms of pathogenesis. ..
  27. Wang X, Jia Y, Fei C, Song X, Li L. Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation. J Biol Chem. 2016;291:26427-26434 pubmed
    ..On the other hand, in the Wnt-off state, the mitosis-specific CDK14-Cyclin Y kinase complex phosphorylates Ser-1490 of LRP5/6 at G2/M, thereby priming the receptor for Wnt-induced ..
  28. Liu H, Shi H, Fan Q, Sun X. Cyclin Y regulates the proliferation, migration, and invasion of ovarian cancer cells via Wnt signaling pathway. Tumour Biol. 2016;37:10161-75 pubmed publisher
    This study is designated to investigate the roles of cyclin Y (CCNY) and Wnt signaling pathway in regulating ovarian cancer (OC) cell proliferation, migration, and invasion...
  29. Cleynen I, Mahachie John J, Henckaerts L, Van Moerkercke W, Rutgeerts P, Van Steen K, et al. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. PLoS ONE. 2010;5:e12952 pubmed publisher
    ..The used technique can be applied to other common complex diseases as well, and will help to complete patient characterization, in order to evolve towards personalized medicine. ..
  30. Yan F, Wang X, Zhu M, Hu X. RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth. Oncol Rep. 2016;36:2793-2799 pubmed publisher
    Cyclin Y (CCNY) is a newly identified PFTK1 interacting protein and has been found to be associated with the proliferation and tumorigenesis of human non-small cell lung cancer...
  31. Xu Y, Wang Z, Wang J, Li J, Wang H, Yue W. Lentivirus-mediated knockdown of cyclin Y (CCNY) inhibits glioma cell proliferation. Oncol Res. 2010;18:359-64 pubmed
    b>Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers...
  32. Wang K, Baldassano R, Zhang H, Qu H, Imielinski M, Kugathasan S, et al. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet. 2010;19:2059-67 pubmed publisher
    ..loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk...
  33. Weersma R, Stokkers P, Cleynen I, Wolfkamp S, Henckaerts L, Schreiber S, et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am J Gastroenterol. 2009;104:630-8 pubmed publisher
    ..51E-05), 5p13 (rs17234657, P=2.62E-05), and 10q21 (rs10761659, P=8.95E-04). We also identified associations with cyclin Y (CCNY; rs3936503, P=2.09 E-04) and Hect domain and RCC1-like domain 2 (HERC2; rs916977, P=1.12E-04)...
  34. Argyropoulos G, Stütz A, Ilnytska O, Rice T, Teran Garcia M, Rao D, et al. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. Physiol Genomics. 2009;36:79-88 pubmed publisher
    ..Furthermore, training-induced changes in submaximal exercise stroke volume may be due to mitochondrial function and variation in KIF5B expression as determined by functional SNPs in its promoter. ..
  35. Yue W, Zhao X, Zhang L, Xu S, Liu Z, Ma L, et al. Cell cycle protein cyclin Y is associated with human non-small-cell lung cancer proliferation and tumorigenesis. Clin Lung Cancer. 2011;12:43-50 pubmed publisher
    The role of cell cycle protein cyclin Y (CCNY) in non-small-cell lung cancer (NSCLC) is not clear. Hence, the aim of this study was to explore the potential role of CCNY in lung cancer...
  36. Li S, Song W, Jiang M, Zeng L, Zhu X, Chen J. Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation. FEBS Lett. 2014;588:1989-96 pubmed publisher
    b>Cyclin Y, a membrane associated cyclin, is capable of binding and activating CDK14...
  37. Sun T, Co N, Wong N. PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma. Biochem Biophys Res Commun. 2014;449:163-8 pubmed publisher
    ..the modulated pathway underlining the PFTK1 action, here we show a physical interaction between PFTK1 and cyclin Y (CCNY) in promoting noncanonical Wnt signaling...
  38. Shehata S, Deak M, Morrice N, Ohta E, Hunter R, Kalscheuer V, et al. Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16. Biochem J. 2015;469:409-20 pubmed publisher
    ..b>Cyclin Y has recently been identified as a key interacting/activating cyclin for PCTAIRE-1; however, the molecular ..
  39. Durand G, Dausse E, Goux E, Fiore E, Peyrin E, Ravelet C, et al. A combinatorial approach to the repertoire of RNA kissing motifs; towards multiplex detection by switching hairpin aptamers. Nucleic Acids Res. 2016;44:4450-9 pubmed publisher
    ..We identified more than 50 pairs of kissing RNA hairpins. Two kissing motifs, 5'CCNY and 5'RYRY, generate highly stable complexes with KDs in the low nanomolar range...