CCNH

Summary

Gene Symbol: CCNH
Description: cyclin H
Alias: CAK, CycH, p34, p37, cyclin-H, CAK complex subunit, CDK-activating kinase complex subunit, MO15-associated protein, cyclin-dependent kinase-activating kinase complex subunit
Species: human
Products:     CCNH

Top Publications

  1. Fisher R, Morgan D. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell. 1994;78:713-24 pubmed
    ..Cloning of a cDNA encoding the 37 kDa subunit identifies it as a novel cyclin (cyclin H)...
  2. Adamczewski J, Rossignol M, Tassan J, Nigg E, Moncollin V, Egly J. MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH. EMBO J. 1996;15:1877-84 pubmed
    MAT1, cyclin H and cdk7 are part of TFIIH, a class II transcription factor which possesses numerous subunits of which several have been shown to be involved in processes other than transcription...
  3. Nekhai S, Shukla R, Kumar A. A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity. J Virol. 1997;71:7436-41 pubmed
    ..60% of Tat-associated CTD kinase copurifies with CDK2 kinase activity and contains the CAK components CDK7 and cyclin H. The rest of Tat-associated kinase is free of CDK2 kinase activity and the CAK components and thus may represent ..
  4. Cujec T, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan D, et al. The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev. 1997;11:2645-57 pubmed
    ..cyclin-dependent kinase 7 (CDK7), which leads to productive interactions between Tat and the CDK-activating kinase (CAK) complex and between Tat and TFIIH...
  5. Nekhai S, Shukla R, Fernandez A, Kumar A, Lamb N. Cell cycle-dependent stimulation of the HIV-1 promoter by Tat-associated CAK activator. Virology. 2000;266:246-56 pubmed
    ..We reported a Tat-associated CAK/CTD kinase from mitogenically induced primary human T-cells (TTK) (S. Nekhai et al., 1997, J. Virol. 71, 7436-7441)...
  6. Rossignol M, Kolb Cheynel I, Egly J. Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH. EMBO J. 1997;16:1628-37 pubmed
    ..Three subunits of TFIIH, cdk7, cyclin H and MAT1, form a ternary complex, cdk-activating kinase (CAK), found either on its own or as part of TFIIH...
  7. García Martínez L, Mavankal G, Neveu J, Lane W, Ivanov D, Gaynor R. Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription. EMBO J. 1997;16:2836-50 pubmed
    ..These results define a cellular kinase complex whose activity is modulated by Tat to result in activation of HIV-1 trancription. ..
  8. Isel C, Karn J. Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation. J Mol Biol. 1999;290:929-41 pubmed
    ..We conclude that activation of the CDK9 kinase, leading to CTD phosphorylation, occurs only in elongation complexes that have transcribed through the Tat-recognition element, TAR RNA. ..
  9. Nekhai S, Zhou M, Fernandez A, Lane W, Lamb N, Brady J, et al. HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription. Biochem J. 2002;364:649-57 pubmed
    ..They are also consistent with the observed cell-cycle-specific induction of viral gene transactivation. ..

More Information

Publications172 found, 100 shown here

  1. Wang Y, Sun X, Fang L, Li K, Yang P, Du L, et al. Genomic instability in adult men involved in processing electronic waste in Northern China. Environ Int. 2018;117:69-81 pubmed publisher
    ..of e-waste, there were 13 genes - ATM, ATR, ABL1, CHEK1, CHEK2, GADD45A, CDK7, GTSE1, OGG1, DDB1, PRKDC, XRCC1 and CCNH - for which expression of mRNA was up-regulated and 7 genes - BRCA1, GTF2H1, SEMA4A, MRE11A, MUTYH, PNKP and RAD50 -..
  2. Gupta E, Pachauri M, Ghosh P, Rajam M. Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line. Tumour Biol. 2016;37:1159-71 pubmed publisher
    ..genes, it was observed that RNAi against PA biosynthetic genes downregulated the expression of CDK8, CCNE2, CCNH, CCNT1, CCNT2, CCNF, PCNA, CCND1, and CDK2, and upregulated the expression of E2F4, BAX, FAS, TP53, CDKN1A, BAK1, ..
  3. Sebastian T, Johnson P. RasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescence. Cancer Res. 2009;69:2588-98 pubmed publisher
    ..Ectopic expression of p34 C/EBPbeta (LAP) inhibited Ras(V12)-mediated transformation of NIH 3T3 cells, suppressed their tumorigenicity in ..
  4. Hendrayani S, Al Khalaf H, Aboussekhra A. The cytokine IL-6 reactivates breast stromal fibroblasts through transcription factor STAT3-dependent up-regulation of the RNA-binding protein AUF1. J Biol Chem. 2014;289:30962-76 pubmed publisher
    ..inhibits IL-6-dependent activation of breast stromal fibroblasts, whereas AUF1 ectopic expression of p37(AUF1) activated these cells and enhanced their paracrine induction of epithelial-to-mesenchymal transition in ..
  5. Dai J, Leng L, Lu C, Gong F, Zhang S, Zheng W, et al. Time-lapse observation and transcriptome analysis of a case with repeated multiple pronuclei after IVF/ICSI. J Assist Reprod Genet. 2017;34:1189-1197 pubmed publisher
    ..From 25 DEGs, three genes, DYNC2LI1, NEK2, and CCNH, which are involved in meiosis and the chromosome separation process, were further validated by real-time PCR...
  6. Rocha A, Paternot S, Coulonval K, Dumont J, Soares P, Roger P. Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation. Mol Biol Cell. 2008;19:4814-25 pubmed publisher
  7. Cruz Becerra G, Valerio Cabrera S, Juárez M, Bucio Mendez A, Zurita M. TFIIH localization is highly dynamic during zygotic genome activation in Drosophila, and its depletion causes catastrophic mitosis. J Cell Sci. 2018;131: pubmed publisher
    ..Furthermore, embryos with defects in subunits of either the CAK or the core subcomplexes of TFIIH show catastrophic mitosis...
  8. Deshmukh A, Mitra P, Kolagani A, Gurupwar R. Cdk-related kinase 9 regulates RNA polymerase II mediated transcription in Toxoplasma gondii. Biochim Biophys Acta Gene Regul Mech. 2018;1861:572-585 pubmed publisher
    ..Interestingly, TgCrk9 kinase activity is regulated by the upstream TgCrk7 based CAK complex...
  9. González Montoya M, Hernández Ledesma B, Mora Escobedo R, Martinez Villaluenga C. Bioactive Peptides from Germinated Soybean with Anti-Diabetic Potential by Inhibition of Dipeptidyl Peptidase-IV, α-Amylase, and α-Glucosidase Enzymes. Int J Mol Sci. 2018;19: pubmed publisher
    ..Peptides in F1, F2, and F3 were mainly fragments from β-conglycinin, glycinin, and P34 thiol protease...
  10. Strasser K, Lueckemann L, Kluever V, Thavaneetharajah S, Hoeber D, Bendix I, et al. Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brain. Brain Res. 2016;1646:116-124 pubmed publisher
    ..On P28 to P37 long-term outcome was assessed by neurobehavioral testing...
  11. Seoane M, Buhs S, Iglesias P, Strauss J, Puller A, Muller J, et al. Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair. Oncogene. 2019;: pubmed publisher
    ..pulse regulation through TFIIH, and experimental depletion of MITF results in consecutive loss of CDK7 in the TFIIH-CAK subcomplex...
  12. Vitorino Carvalho A, Courousse N, Crochet S, Coustham V. Identification of Reference Genes for Quantitative Gene Expression Studies in Three Tissues of Japanese Quail. Genes (Basel). 2019;10: pubmed publisher
    ..genes was defined and validated by a differential analysis of gene expression between females and males (CCNH in brain and RPL19 in pectoral muscle)...
  13. Kang J, Yoon H, Kim S, Park J, Hyun Y, Ko A, et al. Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways. Int J Mol Sci. 2018;19: pubmed publisher
    ..increased DPC proliferation but also upregulated levels of cell cycle-associated proteins such as cyclin D1 and cdc2 p34. These results show that FFO extract and DHA promote hair growth through the anagen-activating pathways in DPC.
  14. Valka J, Vesela J, Votavova H, Dostalova Merkerova M, Urbanová Z, Jonasova A, et al. Genetic Variant Screening of DNA Repair Genes in Myelodysplastic Syndrome Identifies a Novel Mutation in the XRCC2 Gene. Oncol Res Treat. 2019;:20-25 pubmed publisher
    ..03), rs12917 (MGMT, p = 0.003), rs2230641 (CCNH, p = 0.01), rs2228529 and rs2228526 (ERCC6, p = 0.04 and p = 0.03), and rs1799977 (MLH1, p = 0.04)...
  15. Thwaites T, Nogueira A, Campeotto I, Silva A, Grieshaber S, Carabeo R. The Chlamydia effector TarP mimics the mammalian leucine-aspartic acid motif of paxillin to subvert the focal adhesion kinase during invasion. J Biol Chem. 2014;289:30426-42 pubmed publisher
    ..The conserved leucine residues within the L(D/E)XLLXXL motif were essential to the recruitment of FAK, Cdc42, p34(Arc), and actin to the plasma membrane...
  16. Peng L, Luo D. Identification of key genes and construction of microRNA-mRNA regulatory networks in bladder smooth muscle cell response to mechanical stimuli using microarray expression profiles and bioinformatics analysis. World J Urol. 2018;36:241-247 pubmed publisher
    ..Moreover, 36 genes in the PPI network were identified as hub genes in BSMCs response to mechanical stretch, e.g. CCNH, CPSF2, TSNAX, ARPC5 and PSMD3 genes...
  17. Omerza G, Tio C, Philips T, Diamond A, Neiman A, Winter E. The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. Mol Biol Cell. 2018;29:66-74 pubmed publisher
    ..Here, we show that Ama1 activates autophosphorylation of Smk1 on Y209 by promoting formation of the Ssp2/Smk1 complex at PSMs. These findings link meiotic exit to Smk1 activation and spore wall assembly. ..
  18. Xie W, Wang S, Hu S, Xu J, Medeiros L, Tang G. Myeloproliferative neoplasm with ABL1/ETV6 rearrangement mimics chronic myeloid leukemia and responds to tyrosine kinase inhibitors. Cancer Genet. 2018;228-229:41-46 pubmed publisher
    ..with MPN with clinicopathologic features resembling chronic myeloid leukemia, but there was no evidence of t(9;22)(p34.1;q11.2) or BCR-ABL1 fusion...
  19. Houten B, Kuper J, Kisker C. Role of XPD in cellular functions: To TFIIH and beyond. DNA Repair (Amst). 2016;44:136-142 pubmed publisher
    ..of the key disease causing variants that affect XPD's interaction with TFIIH and the CDK-activating kinase complex (CAK), we investigate these intriguing cellular roles of XPD and highlight important unanswered questions that provide a ..
  20. Li X, Tian G, Shen H, Liu J. Metabolic engineering of Escherichia coli to produce zeaxanthin. J Ind Microbiol Biotechnol. 2015;42:627-36 pubmed publisher
    ..coli BETA-1 containing pZSPBA-2(P37-crtZPAN) that produced higher amounts of zeaxanthin (11.95 ± 0...
  21. Yoon J, Jo M, White E, De S, Hafner M, Zucconi B, et al. AUF1 promotes let-7b loading on Argonaute 2. Genes Dev. 2015;29:1599-604 pubmed publisher
    ..The RBP AU-rich-binding factor 1 (AUF1) isoform p37 was found to have high affinity for the microRNA let-7b in vitro (Kd = ∼ 6 nM) in cells...
  22. Tong Y, Yan S, Shi J, Chen L, Wan C, Xu K. [Genetic analysis of an infant with duplication 9q34 syndrome]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018;35:437-439 pubmed publisher
    ..3 Mb duplication at 9q34.11-q34.3. G-banding analysis suggested that the infant has a 46,XX,der(1)add(1)(p34.1) karyotype, while her father was 46, XY, t(1,9)(p36.3;q34.1)...
  23. Boice M, Salloum D, Mourcin F, Sanghvi V, Amin R, Oricchio E, et al. Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells. Cell. 2016;167:405-418.e13 pubmed publisher
    ..Accordingly, administration of the HVEM ectodomain protein (solHVEM(P37-V202)) binds BTLA and restores tumor suppression...
  24. Sroor F, Vendier L, Etienne M. Cyclooctatetraenyl calcium and strontium amido complexes. Dalton Trans. 2018;47:12587-12595 pubmed publisher
    ..bond, length as m-dash]CH in benzene yielded an insoluble complex tentatively formulated as the polymeric complex [CaK(CCPh)(C8H8)(thf)x]n (4)...
  25. Graf L, Feichtinger S, Naing Z, Hutterer C, Milbradt J, Webel R, et al. New insight into the phosphorylation-regulated intranuclear localization of human cytomegalovirus pUL69 mediated by cyclin-dependent kinases (CDKs) and viral CDK orthologue pUL97. J Gen Virol. 2016;97:144-51 pubmed publisher
    ..These findings provide new insight into pUL69 kinase interregulation and emphasize the importance of pUL69 phosphorylation for correct intranuclear localization. ..
  26. Dugina V, Khromova N, Rybko V, Blizniukov O, Shagieva G, Chaponnier C, et al. Tumor promotion by γ and suppression by β non-muscle actin isoforms. Oncotarget. 2015;6:14556-71 pubmed
    ..In contrast, γ-cytoplasmic actin increases the oncogenic potential via ERK1/2, p34-Arc, WAVE2, cofilin1, PP1 and other regulatory proteins...
  27. Shaheen R, Maddirevula S, Ewida N, Alsahli S, Abdel Salam G, Zaki M, et al. Genomic and phenotypic delineation of congenital microcephaly. Genet Med. 2019;21:545-552 pubmed publisher
    ..genes, confirming the candidacy of ANKLE2, YARS, FRMD4A, and THG1L, and proposing the candidacy of BPTF, MAP1B, CCNH, and PPFIBP1...
  28. Helenius L, Puhakka A, Manner T, Pajulo O, Helenius I. Preoperative pregabalin has no effect on intraoperative neurophysiological monitoring in adolescents undergoing posterior spinal fusion for spinal deformities: a double-blind, randomized, placebo-controlled clinical trial. Eur Spine J. 2018;27:298-304 pubmed publisher
    ..no statistically significant differences between the study groups regarding the latency of bilateral SSEP (N32 and P37) and MEP latencies at any time point...
  29. Sang C, Tian H, Chen Y, Liu J, Chen S, Hui L. Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4'-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors. Bioorg Med Chem Lett. 2018;28:71-76 pubmed publisher
    ..These compounds also arrested A549 cells cycle in G2/M phase by regulating cyclinB1/cdc2(p34). Taken together, these results show that a series of compounds are potential anticancer agents.
  30. Duan H, Qu L, Shou C. Mycoplasma hyorhinis induces epithelial-mesenchymal transition in gastric cancer cell MGC803 via TLR4-NF-κB signaling. Cancer Lett. 2014;354:447-54 pubmed publisher
    ..Furthermore, we found that TLR4 associated with p37, a membrane protein of M. hyorhinis. Knock-down or inhibition of TLR4 antagonized M...
  31. Jin R, Chen Q, Yao S, Bai E, Fu W, Wang L, et al. Synthesis and anti-tumor activity of EF24 analogues as IKKβ inhibitors. Eur J Med Chem. 2018;144:218-228 pubmed publisher
    ..IKKβ phosphorylation, and followed arrested the cell cycle at G2/M phase by suppressing the Cyclin B1 and Cdc2 p34 expression, induced the cell apoptosis by down-regulating Bcl-2 protein and up-regulating cleaved-caspase3...
  32. Dinani N, Ali M, Liu L, McGrath J, Mellerio J. Mutations in AAGAB underlie autosomal dominant punctate palmoplantar keratoderma. Clin Exp Dermatol. 2017;42:316-319 pubmed publisher
    ..The causative gene for PPPK1 has been identified as AAGAB, which encodes ?- and ?-adaptin-binding protein p34. We describe the clinical features in three unrelated families with PPPK1, and report three recurrent causative ..
  33. Jamal Q, Dhasmana A, Lohani M, Firdaus S, Ansari M, Sahoo G, et al. Binding Pattern Elucidation of NNK and NNAL Cigarette Smoke Carcinogens with NER Pathway Enzymes: an Onco- Informatics Study. Asian Pac J Cancer Prev. 2015;16:5311-7 pubmed
    ..The highest obtained docking energy between NNK and enzymes RAD23A, CCNH, CDK7, and CETN2 were -7.13 kcal/mol, -7.27 kcal/mol, -8.05 kcal/mol and -7.58 kcal/mol respectively...
  34. Ni H, Zhao D, Tian T. Ketogenic diet change cPLA2/clusterin and autophagy related gene expression and correlate with cognitive deficits and hippocampal MFs sprouting following neonatal seizures. Epilepsy Res. 2016;120:13-8 pubmed publisher
    ..Morris water maze test was performed during P37-P43...
  35. Schneider E, Kartarius S, Schuster N, Montenarh M. The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H. Oncogene. 2002;21:5031-7 pubmed
    ..Here, we show that cyclin H was phosphorylated by protein kinase CK2...
  36. Nag R, Niggli S, Sousa Guimarães S, Vazquez Pianzola P, Suter B. Mms19 is a mitotic gene that permits Cdk7 to be fully active as a Cdk-activating kinase. Development. 2018;145: pubmed publisher
    ..kinase (CAK) complex, an activator of mitotic Cdk1, suggesting that Mms19 functions in mitosis to allow CAK (Cdk7/Cyclin H/Mat1) to become fully active as a Cdk1-activating kinase...
  37. Giehl K, Herzinger T, Wolff H, Sárdy M, von Braunmühl T, Dekeuleneer V, et al. Eight Novel Mutations Confirm the Role of AAGAB in Punctate Palmoplantar Keratoderma Type 1 (Buschke-Fischer-Brauer) and Show Broad Phenotypic Variability. Acta Derm Venereol. 2016;96:468-72 pubmed publisher
    ..mutations in 3 families, in the AAGAB gene on 15q, which encodes the alpha- and gamma-adaptin-binding protein p34. The current study examined 14 additional families, comprising a total of 26 affected individuals and identified 8 ..
  38. Paul D, Casari C, Wu C, Piatt R, Pasala S, Campbell R, et al. Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Adv. 2017;1:1398-1408 pubmed publisher
    ..The Arpc2 gene, encoding the p34 subunit of the Arp2/3 complex, was deleted in the megakaryocyte lineage (Arpc2fl/flPF4-Cre)...
  39. Zhang M, Wu J, Huo L, Luo L, Song X, Fan F, et al. Environmental Enrichment Prevent the Juvenile Hypoxia-Induced Developmental Loss of Parvalbumin-Immunoreactive Cells in the Prefrontal Cortex and Neurobehavioral Alterations Through Inhibition of NADPH Oxidase-2-Derived Oxidative Stress. Mol Neurobiol. 2016;53:7341-7350 pubmed
    ..After the daily exposure, the rats were raised in SE or EE. In the PFC of P34 rats, we determined the impact (i) of IH exposures on NOX2-derived oxidative stress and PV immunoreactivity, (ii) ..
  40. Gupton T, Delgado J, Jaramillo D, Cahill A, Chauvin N. Comparative analysis of anterior and posterior contrast injection approaches for shoulder MR arthrograms in adolescents. Pediatr Radiol. 2016;46:1848-1855 pubmed
    ..We recorded total fluoroscopic time, dose-area product (DAP) and cumulative air kerma (CAK)...
  41. Schwartz S, Kale E, Husain A. Lower Extremity Somatosensory Evoked Potential P37 Waveform Optimization. Neurodiagn J. 2018;58:174-181 pubmed publisher
    ..These SEPs produce a P37 waveform that is recorded from scalp electrodes...
  42. Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt D, et al. The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH. Nucleic Acids Res. 2017;45:10872-10883 pubmed publisher
    ..In this study, we focused on the p44 and the p34 subunits, which are central for the structural integrity of core-TFIIH...
  43. Liu J, Flanagan W, Drazba J, Estes M, Barnett G, Haqqi T, et al. The CDK inhibitor, p27Kip1, is required for IL-4 regulation of astrocyte proliferation. J Immunol. 1997;159:812-9 pubmed
    ..Reduced cyclin E-associated cdk2 activity was not due to impaired cyclin-dependent kinase-activating kinase (CAK) activity, which was unaffected by IL-4...
  44. Mandal M, Bandyopadhyay D, Goepfert T, Kumar R. Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK). Oncogene. 1998;16:217-25 pubmed
    ..CDKs in IFN-treated cells by delineating the potential role(s) of CDK-inhibitors (CKIs) and CDK-activating kinase (CAK)...
  45. Stettler K, Li X, Sandrock B, Braga Lagache S, Heller M, Dümbgen L, et al. A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. Dis Model Mech. 2015;8:81-91 pubmed publisher
    ..showed a reduced interaction with the core TFIIH and also an abnormal interaction with the Cdk-activating kinase (CAK) complex...
  46. Liu Y, Wei B, Zhuo R, Wen D, Ding D, Xu Y, et al. Determination of the conventional true value of gamma-ray air kerma in a minitype reference radiation. Appl Radiat Isot. 2016;118:238-245 pubmed publisher
    ..daily used gamma-ray dose rate meters, were used as samples to determine the conventional true value of air kerma (CAK) at the point of test in the MRR...
  47. Ford B, Ruttan C, Kyle V, Brackley M, Glickman B. Identification of single nucleotide polymorphisms in human DNA repair genes. Carcinogenesis. 2000;21:1977-81 pubmed
    ..HSP may be used for any sequence that can be amplified by PCR. A total of 12 SNP variants in MGMT, ERCC1, CDK7, CCNH and XRCC4 were identified, 11 at polymorphic frequencies, with an average frequency of 0...
  48. Wolfertstetter S, Reinders J, Schwede F, Ruth P, Schinner E, Schlossmann J. Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues. PLoS ONE. 2015;10:e0126057 pubmed publisher
    ..These purine cyclic nucleotides activate cAK and cGK, respectively...
  49. Colon L, Odynocki N, Santarelli A, Poulos A. Sexual differentiation of contextual fear responses. Learn Mem. 2018;25:230-240 pubmed publisher
    ..and five trials) the long-term retrieval of cued and context fear in preadolescent (P24 and P33), periadolescent (P37), and adult (P60 and P90) rats...
  50. Kawamoto M, Wada Y, Koya N, Takami Y, Saitsu H, Ishizaki N, et al. Long-term survival of a patient with recurrent gallbladder carcinoma, treated with chemotherapy, immunotherapy, and surgery: a case report. Surg Case Rep. 2018;4:115 pubmed publisher
    ..was detected in segment 5 (S5) of his liver, we started adoptive immunotherapies with cytokine-activated killer (CAK) cell infusions, combined with chemotherapy...
  51. Yankulov K, Bentley D. Transcriptional control: Tat cofactors and transcriptional elongation. Curr Biol. 1998;8:R447-9 pubmed
    ..Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit, contact Tat and contribute to the control of transcriptional elongation. ..
  52. Lee D, Duan H, Chang C. From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. J Biol Chem. 2000;275:9308-13 pubmed
    ..Co-transfection of cdk activating kinase (CAK), the kinase moiety of TFIIH, enhanced AR-mediated transcription in a ligand-dependent manner in human prostate ..
  53. Moisan A, Larochelle C, Guillemette B, Gaudreau L. BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels. Mol Cell Biol. 2004;24:6947-56 pubmed
    ..region can negatively modulate phosphorylation levels of the RNA polymerase II CTD by the Cdk-activating kinase (CAK) in vitro...
  54. Wang Q, Li M, Zhang X, Huang H, Huang J, Ke J, et al. Upregulation of CDK7 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis. Exp Mol Pathol. 2016;100:514-21 pubmed publisher
    CDK7 has been known as a component of CDK activating kinase (CAK) complex, the complex was composed of CDK7, Cyclin H and RING finger protein Mat1 that contribute to cell cycle progression by phosphorylating other CDKs...
  55. Wang G, Harnod T, Chiu T, Chen K. Effect of an Anterior Cingulotomy on Pain, Cognition, and Sensory Pathways. World Neurosurg. 2017;102:593-597 pubmed publisher
    ..The latencies of peaks P20 and P37 of the somatosensory evoked potential (SSEP) conductive time were used to evaluate the intactness of the ..
  56. Damayanti N, Budka J, Khella H, Ferris M, Ku S, Kauffman E, et al. Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma. Clin Cancer Res. 2018;24:5977-5989 pubmed publisher
    ..The presence of a SFPQ-TFE3 fusion [t(X;1) (p11.2; p34)] with chromosomal break-points was identified by RNA-seq and validated by RT-PCR...
  57. Tirode F, Busso D, Coin F, Egly J. Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. Mol Cell. 1999;3:87-95 pubmed
    ..around the start site whereas the XPD helicase, which is dispensable, stimulates transcription and allows the CAK complex to be anchored to TFIIH...
  58. Nguyen T, Hawkins E, Kolluri A, Kmieciak M, Park H, Lin H, et al. Synergism between bosutinib (SKI-606) and the Chk1 inhibitor (PF-00477736) in highly imatinib-resistant BCR/ABL⁺ leukemia cells. Leuk Res. 2015;39:65-71 pubmed publisher
    ..blocked PF-00477736-induced ERK1/2 activation and sharply increased apoptosis in association with Mcl-1 inhibition, p34(cdc2) dephosphorylation, BimEL up-regulation, and DNA damage in imatinib-resistant CML or Ph(+) ALL cell lines...
  59. Zhang X, Gui L, Zhang X, Bulfer S, Sanghez V, Wong D, et al. Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A. 2015;112:E1705-14 pubmed publisher
    ..discovered a previously unidentified disease-relevant functional property of p97 by identifying how the cofactors p37 and p47 regulate p97 ATPase activity...
  60. Lo Y, Teo A, Tan Y, Fook Chong S, Guo C, Yue W, et al. Motor and somatosensory abnormalities are significant etiological factors for adolescent idiopathic scoliosis. J Neurol Sci. 2015;359:117-23 pubmed publisher
    ..For somatosensory evoked potentials (SSEP), peak to peak P37 amplitudes from right and left lower limb SSEP and inter-side P37 amplitude ratios were obtained...
  61. Custodio A, Moreno Rubio J, Aparicio J, Gallego Plazas J, Yaya R, Maurel J, et al. Pharmacogenetic predictors of severe peripheral neuropathy in colon cancer patients treated with oxaliplatin-based adjuvant chemotherapy: a GEMCAD group study. Ann Oncol. 2014;25:398-403 pubmed publisher
  62. Torres L, Garcia R, Blois A, Dati L, Durão A, Alves A, et al. Exposure of Neonatal Mice to Tobacco Smoke Disturbs Synaptic Proteins and Spatial Learning and Memory from Late Infancy to Early Adulthood. PLoS ONE. 2015;10:e0136399 pubmed publisher
    ..Spatial reference and working memory were evaluated in the Morris water maze during infancy (P20-P29), adolescence (P37-P42) and adulthood (P67-P72)...
  63. Gomersall A, Phan H, Iacuone S, Li S, Parish R. The Mycoplasma hyorhinis p37 Protein Rapidly Induces Genes in Fibroblasts Associated with Inflammation and Cancer. PLoS ONE. 2015;10:e0140753 pubmed publisher
    The p37 protein at the surface of Mycoplasma hyorhinis cells forms part of a high-affinity transport system and has been found associated with animal and human cancers...
  64. Chiu H, Huang W, Liao T, Chi P, Nielsen B, Liu J, et al. Mechanistic insights into avian reovirus p17-modulated suppression of cell cycle CDK-cyclin complexes and enhancement of p53 and cyclin H interaction. J Biol Chem. 2018;293:12542-12562 pubmed publisher
    ..cytoplasmic retention of CDKs and cyclins; and inhibition of CDK-activating kinase activity by promoting p53-cyclin H interaction. p17 binds to CDK-cyclin except for CDK1-cyclin B1 and CDK7-cyclin H complexes...
  65. Oakley G, Loberg L, Yao J, Risinger M, Yunker R, Zernik Kobak M, et al. UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein. Mol Biol Cell. 2001;12:1199-213 pubmed
    ..We showed previously that the p34 subunit of RPA becomes hyperphosphorylated as a delayed response (4-8 h) to UV radiation (10-30 J/m(2))...
  66. Ding X, Zhou J, Hu Q, Liu S, Chen G. The tumor suppressor pVHL down-regulates never-in-mitosis A-related kinase 8 via hypoxia-inducible factors to maintain cilia in human renal cancer cells. J Biol Chem. 2015;290:1389-94 pubmed publisher
    ..We demonstrated here that pVHL may be involved in regulating NEK8. We found that CAK-I cells with wild-type vhl expressed a lower level of NEK8 than the cells loss of vhl, such as 786-O, 769-P, and A-..
  67. Alghamdi R, O Reilly P, Lu C, Gomes J, Lagace T, Basak A. LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation. Eur J Med Chem. 2015;92:890-907 pubmed publisher
    ..The effects were particularly significant with peptides P36, P37, P46 and P47...
  68. Wang Y, Liu F, Mao F, Hang Q, Huang X, He S, et al. Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration. J Biol Chem. 2013;288:9028-34 pubmed publisher
    ..Here we report that the cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) complex interacted with CtBP2 in vivo and in vitro...
  69. Yuan S, Qu L, Shou C. N-Terminal Polypeptide of Annexin A2 Decreases Infection of Mycoplasma hyorhinis to Gastric Cancer Cells. PLoS ONE. 2016;11:e0147776 pubmed publisher
    ..hyorhinis) infection was mediated by the interaction between p37 of M. hyorhinis and Annexin A2 (ANXA2) of host cells, however the translational value of this mechanism was unknown...
  70. Rajaraman P, Wang S, Rothman N, Brown M, Black P, Fine H, et al. Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer Epidemiol Biomarkers Prev. 2007;16:1655-61 pubmed
    ..to 12 single nucleotide polymorphisms from 10 genes involved in apoptosis and cell cycle control: CASP8, CCND1, CCNH, CDKN1A, CDKN2A, CHEK1, CHEK2, MDM2, PTEN, and TP53...
  71. Watanabe D, Adanyi N, Takács K, Maczó A, Nagy A, Gelencsér E, et al. Development of soybeans with low P34 allergen protein concentration for reduced allergenicity of soy foods. J Sci Food Agric. 2017;97:1010-1017 pubmed publisher
    ..As a soybean genebank accession low in the immunodominant protein P34 (Gly m Bd 30K) has recently been found, introgression of the low-P34 trait into adapted soybean germplasm has been ..
  72. Kamina A, Williams N. Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP). PLoS ONE. 2017;12:e0177890 pubmed publisher
    ..In Trypanosoma brucei, our laboratory has identified two trypanosome-specific RNA binding proteins P34 and P37 that are involved in the maturation of the 60S subunit during ribosome biogenesis...
  73. Pérez Cañamás M, Hernández C. Key importance of small RNA binding for the activity of a glycine-tryptophan (GW) motif-containing viral suppressor of RNA silencing. J Biol Chem. 2015;290:3106-20 pubmed publisher
    ..The results show that p37, the viral coat protein, blocks RNA silencing...
  74. Lu C, Tian Y, Wang S, Su Y, Mao T, Huang T, et al. Phosphorylation of SPT5 by CDKD;2 Is Required for VIP5 Recruitment and Normal Flowering in Arabidopsis thaliana. Plant Cell. 2017;29:277-291 pubmed publisher
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    ..These observations provide evidence of TFIIE involvement in the transition and suggest that Ser-5 phosphorylation is essential for Pol II to be in the processive elongation form. ..
  76. Santos L, Gomes B, Gouveia R, Silva S, Azevedo A, Camacho V, et al. The role of CCNH Val270Ala (rs2230641) and other nucleotide excision repair polymorphisms in individual susceptibility to well-differentiated thyroid cancer. Oncol Rep. 2013;30:2458-66 pubmed publisher
    ..rs2230641 (ccnh), rs2972388 (cdk7), rs1805329 (rad23b), rs3212986 (ercc1), rs1800067 (ercc4), rs17655, rs2227869 (ercc5), rs4253211 ..
  77. Qing X, Qing A, Ji P, French S, Mason H. Mixed phenotype (T/B/myeloid) extramedullary blast crisis as an initial presentation of chronic myelogenous leukemia. Exp Mol Pathol. 2018;104:130-133 pubmed publisher
    ..biopsy tissue revealed multiple numerical and structural abnormalities including the Ph chromosome (46-49,XX,add(1)(p34),add(3)(p25),add(5)(q13),-6,t(9;22)(q34;q11.2),+10,-15,add(17)(p11.2),+19, +der(22)t(9;22),+mar[cp8])...
  78. Choi Y, Yoon J, Chang J. Crystal Structure of the N-Terminal RNA Recognition Motif of mRNA Decay Regulator AUF1. Biomed Res Int. 2016;2016:3286191 pubmed publisher
    ..To observe how the two RRMs are involved in recognizing ARE, we obtained the AUF1-p37 protein covering the two RRMs...
  79. Chen D, Zhou Q. Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase. Mol Cell Biol. 1999;19:2863-71 pubmed
    ..transcription factor TFIIH complex and increase the phosphorylation of CTD by the Cdk-activating kinase (CAK) complex associated with the core TFIIH...
  80. Bauer A, Podola L, Mann P, Missanga M, Haule A, Sudi L, et al. Preferential Targeting of Conserved Gag Regions after Vaccination with a Heterologous DNA Prime-Modified Vaccinia Virus Ankara Boost HIV-1 Vaccine Regimen. J Virol. 2017;91: pubmed publisher
    ..volunteers received three injections of the DNA-SMI vaccine encoding a subtype B and AB-recombinant Gagp37 and two vaccinations with MVA-CMDR encoding subtype A Gagp55 Gag-specific T-cell responses were ..
  81. Huang W, Berndt S, Kang D, Chatterjee N, Chanock S, Yeager M, et al. Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. Cancer Epidemiol Biomarkers Prev. 2006;15:306-11 pubmed
    ..nonsynonymous SNPs in seven-nucleotide excision repair genes [XPC, RAD23B (hHR23B), CSB (ERCC6), XPD (ERCC2), CCNH, XPF (ERCC4), and XPG (ERCC5)] were genotyped...
  82. Jeang K. Tat, Tat-associated kinase, and transcription. J Biomed Sci. 1998;5:24-7 pubmed
    ..Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb. ..
  83. Eberhardy S, Farnham P. c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J Biol Chem. 2001;276:48562-71 pubmed
    ..In summary, our results suggest that c-Myc activates transcription of cad by stimulating promoter clearance and elongation, perhaps via recruitment of P-TEFb. ..
  84. Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, et al. Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. Nat Struct Mol Biol. 2016;23:580-9 pubmed publisher
    ..and biochemical analyses reveal a functional interaction of MSL1 with CDK7, a subunit of the Cdk-activating kinase (CAK) complex of the general transcription factor TFIIH...
  85. Coin F, Oksenych V, Mocquet V, Groh S, Blattner C, Egly J. Nucleotide excision repair driven by the dissociation of CAK from TFIIH. Mol Cell. 2008;31:9-20 pubmed publisher
    The transcription/DNA repair factor TFIIH is organized into a core that associates with the CDK-activating kinase (CAK) complex...
  86. Jiang J, Tang C, Ren J, Zhang C, Dong L, Zhu Z. Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities. Pediatr neonatol. 2018;59:154-160 pubmed publisher
    ..The ability of learning and memory was assessed using the Morris water maze at P37 and P97. The hippocampal volume was measured by magnetic resonance imaging (MRI) at P37 and P97...
  87. Gnatt A, Cramer P, Fu J, Bushnell D, Kornberg R. Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution. Science. 2001;292:1876-82 pubmed
    ..Protein-nucleic acid contacts help explain DNA and RNA strand separation, the specificity of RNA synthesis, "abortive cycling" during transcription initiation, and RNA and DNA translocation during transcription elongation. ..
  88. Patel H, Abduljabbar R, Lai C, Periyasamy M, Harrod A, Gemma C, et al. Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer. Clin Cancer Res. 2016;22:5929-5938 pubmed
    ..for the regulation of the cell cycle and is a trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the accessory protein, MAT1...
  89. Kohlbrenner R, Kolli K, Taylor A, Kohi M, Lehrman E, Fidelman N, et al. Radiation Dose Reduction during Uterine Fibroid Embolization Using an Optimized Imaging Platform. J Vasc Interv Radiol. 2017;28:1129-1135.e1 pubmed publisher
    ..Cumulative kerma-area product (CKAP), cumulative air kerma (CAK), total fluoroscopy time, and image exposure number were collected for each procedure...
  90. Chinnadurai S, Gandhirajan D, Srinivasan A, Kesavamurthy B, Ranganathan L, Pamidimukkala V. Predicting falls in multiple sclerosis: Do electrophysiological measures have a better predictive accuracy compared to clinical measures?. Mult Scler Relat Disord. 2018;20:199-203 pubmed publisher
    ..VEMP and SEP tests were done and the baseline P13/N23 cVEMP latencies, N10 oVEMP latency, and P37 lower limb SEP latency were obtained...
  91. Poterszman A, Andersen G, Busso D, Rossignol M, Egly J, Thierry J. Expression in Escherichia coli: purification and characterization of cyclin H, a subunit of the human general transcription/DNA repair factor TFIIH. Protein Expr Purif. 1997;9:153-8 pubmed
    The human cyclin H, a protein normally associated with the cyclin-dependent kinase cdk7, was overexpressed in Escherichia coli using a T7 RNA polymerase expression system and further purified to apparent homogeneity...
  92. Li Y, Jin G, Wang H, Liu H, Qian J, Gu S, et al. Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. Lung Cancer. 2007;58:171-83 pubmed
    ..Recent observations reveal that the components of CAK: Cdk7, MAT1 and cyclin H, may play important roles in cell cycle control, transcriptional control, and DNA repairing process, all of which ..