CCM2

Summary

Gene Symbol: CCM2
Description: CCM2 scaffold protein
Alias: C7orf22, OSM, PP10187, cerebral cavernous malformations 2 protein, CCM2 scaffolding protein, cerebral cavernous malformation 2, malcavernin, osmosensing scaffold for MEKK3
Species: human
Products:     CCM2

Top Publications

  1. Penco S, Ratti R, Bianchi E, Citterio A, Patrosso M, Marocchi A, et al. Molecular screening test in familial forms of cerebral cavernous malformation: the impact of the Multiplex Ligation-dependent Probe Amplification approach. J Neurosurg. 2009;110:929-34 pubmed publisher
    ..Probe Amplification analysis integrates the consecutive sequence analysis of the 3 genes (Krit1/CCM1, MGC4607/CCM2, and PDCD10/CCM3) known to be responsible for cerebral cavernous malformation lesions...
  2. Crose L, Hilder T, Sciaky N, Johnson G. Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells. J Biol Chem. 2009;284:13301-5 pubmed publisher
    Mutation of CCM2 predisposes individuals to cerebral cavernous malformations, vascular abnormalities that cause seizures and hemorrhagic stroke. CCM2 has been proposed to regulate the activity of RhoA for maintenance of vascular integrity...
  3. Liquori C, Berg M, Squitieri F, Leedom T, Ptacek L, Johnson E, et al. Deletions in CCM2 are a common cause of cerebral cavernous malformations. Am J Hum Genet. 2007;80:69-75 pubmed
    ..Mutations in the gene KRIT1 are responsible for CCM1, mutations in the gene MGC4607 are responsible for CCM2, and mutations in the gene PDCD10 are responsible for CCM3...
  4. D Angelo R, Marini V, Rinaldi C, Origone P, Dorcaratto A, Avolio M, et al. Mutation analysis of CCM1, CCM2 and CCM3 genes in a cohort of Italian patients with cerebral cavernous malformation. Brain Pathol. 2011;21:215-24 pubmed publisher
    ..Familial cases are associated with mutations in CCM1[K-Rev interaction trapped 1 (KRIT1)], CCM2 (MGC4607) and CCM3 (PDCD10) genes...
  5. Liquori C, Berg M, Siegel A, Huang E, Zawistowski J, Stoffer T, et al. Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations. Am J Hum Genet. 2003;73:1459-64 pubmed
    ..We report that a novel gene, MGC4607, exhibits eight different mutations in nine families with type 2 CCM (CCM2). MGC4607, similar to the KRIT1 binding partner ICAP1alpha, encodes a protein with a phosphotyrosine-binding domain...
  6. Stahl S, Gaetzner S, Voss K, Brackertz B, Schleider E, Sürücü O, et al. Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex. Hum Mutat. 2008;29:709-17 pubmed publisher
    ..of direct sequencing and MLPA analyses, we identified 15 novel and eight previously published CCM1 (KRIT1), CCM2, and CCM3 (PDCD10) mutations...
  7. Hogan B, Bussmann J, Wolburg H, Schulte Merker S. ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Hum Mol Genet. 2008;17:2424-32 pubmed publisher
    ..Heritable forms are caused by mutations in CCM1, CCM2 and CCM3, but despite the importance of these factors in vascular biology, an understanding of their molecular and ..
  8. Akers A, Johnson E, Steinberg G, Zabramski J, Marchuk D. Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis. Hum Mol Genet. 2009;18:919-30 pubmed publisher
    ..Familial cases follow autosomal-dominant inheritance due to mutations in one of three genes, CCM1/KRIT1, CCM2/malcavernin or CCM3/PDCD10...
  9. Kleaveland B, Zheng X, Liu J, Blum Y, Tung J, Zou Z, et al. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med. 2009;15:169-76 pubmed publisher
    ..CCMs) are human vascular malformations caused by mutations in three genes of unknown function: KRIT1, CCM2 and PDCD10...

More Information

Publications108 found, 100 shown here

  1. Denier C, Goutagny S, Labauge P, Krivosic V, Arnoult M, Cousin A, et al. Mutations within the MGC4607 gene cause cerebral cavernous malformations. Am J Hum Genet. 2004;74:326-37 pubmed
    ..CCM loci have already been assigned to chromosomes 7q (CCM1), 7p (CCM2), and 3q (CCM3) and have been identified in 40%, 20%, and 40%, respectively, of families with CCM...
  2. Seker A, Pricola K, Guclu B, Ozturk A, Louvi A, Gunel M. CCM2 expression parallels that of CCM1. Stroke. 2006;37:518-23 pubmed
    Mutations in CCM2 (MGC4607 or malcavernin) cause familial cerebral cavernous malformation (CCM), an autosomal dominant neurovascular disease. Both the function of this molecule and the pathogenesis of the disease remain elusive...
  3. Gianfrancesco F, Cannella M, Martino T, Maglione V, Esposito T, Innocenzi G, et al. Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:691-5 pubmed
    ..In a CCM2 affected family, we also report a novel causative mutation, (54_55delAC) in exon 2 of the MGC4607 gene, that ..
  4. Voss K, Stahl S, Schleider E, Ullrich S, Nickel J, Mueller T, et al. CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. Neurogenetics. 2007;8:249-56 pubmed
    Individuals carrying a mutation in one of the three cerebral cavernous malformation genes (CCM1/KRIT1, CCM2, CCM3) cannot be clinically distinguished, raising the possibility that they act within common molecular pathways...
  5. Pagenstecher A, Stahl S, Sure U, Felbor U. A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells. Hum Mol Genet. 2009;18:911-8 pubmed publisher
    ..Familial cerebral cavernous malformations (CCMs) have been associated with germline mutations in CCM1/KRIT1, CCM2 or CCM3/PDCD10...
  6. Harel L, Costa B, Tcherpakov M, Zapatka M, Oberthuer A, Hansford L, et al. CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Neuron. 2009;63:585-91 pubmed publisher
    ..Here, we show that CCM2, a gene product associated with cerebral cavernous malformations, interacts with the juxtamembrane region of TrkA ..
  7. Stockton R, Shenkar R, Awad I, Ginsberg M. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med. 2010;207:881-96 pubmed publisher
    ..Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell-cell ..
  8. Tsutsumi S, Ogino I, Miyajima M, Ikeda T, Shindo N, Yasumoto Y, et al. Genomic causes of multiple cerebral cavernous malformations in a Japanese population. J Clin Neurosci. 2013;20:667-9 pubmed publisher
    ..are thought to arise in association with genomic mutations in the cerebral cavernous malformation 1 (CCM1) (KRIT1), CCM2 (MGC4607), and CCM3 (PDCD10) genes...
  9. Craig H, Gunel M, Cepeda O, Johnson E, Ptacek L, Steinberg G, et al. Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27. Hum Mol Genet. 1998;7:1851-8 pubmed
    ..In addition to linkage to CCM1, analysis of linkage demonstrates linkage to two new loci, CCM2 at 7p13-15 and CCM3 at 3q25.2-27. Multilocus analysis yields a maximum lod score of 14...
  10. Zawistowski J, Stalheim L, Uhlik M, Abell A, Ancrile B, Johnson G, et al. CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. Hum Mol Genet. 2005;14:2521-31 pubmed
    ..KRIT1 (CCM1) or in malcavernin (CCM2), the murine ortholog of which was concurrently characterized as osmosensing scaffold for MEKK3 (OSM). The roles of the CCM proteins in the pathogenesis of the disorder remain largely unknown...
  11. Zhang J, Rigamonti D, Dietz H, Clatterbuck R. Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations. Neurosurgery. 2007;60:353-9; discussion 359 pubmed
    ..Mutations in krit1 and malcavernin, the proteins encoded by the genes at the CCM1 and CCM2 loci, respectively, are responsible for the majority of ..
  12. Whitehead K, Chan A, Navankasattusas S, Koh W, London N, Ling J, et al. The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med. 2009;15:177-84 pubmed publisher
    ..Loss of function mutations in the CCM2 gene cause CCM...
  13. D Angelo R, Scimone C, Rinaldi C, Trimarchi G, Italiano D, Bramanti P, et al. CCM2 gene polymorphisms in Italian sporadic patients with cerebral cavernous malformation: a case-control study. Int J Mol Med. 2012;29:1113-20 pubmed publisher
    ..penetrance and variable clinical expression attributable to mutations in three different genes: CCM1 (Krit1), CCM2 (MGC4607) and CCM3 (PDCD10)...
  14. Duong H, Yin Y, Thambi T, Nguyen T, Giang Phan V, Lee M, et al. Smart vaccine delivery based on microneedle arrays decorated with ultra-pH-responsive copolymers for cancer immunotherapy. Biomaterials. 2018;185:13-24 pubmed publisher
    ..DNA vaccine was laden on microneedles (MNs) assembled with layer-by-layer coating of ultra-pH-responsive OSM-(PEG-PAEU) and immunostimulatory adjuvant poly(I:C), a synthetic double stranded RNA...
  15. Xiao J, Liong E, Huang H, On Tse W, Lau K, Pan J, et al. Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. Toxicol Sci. 2015;143:430-40 pubmed publisher
    ..In addition, level of hepato-protective molecules (eg, OSM and OSMR) and associated liver regeneration pathway were significantly inhibited by the deficiency of COX-1 but ..
  16. Rerat K, Parker F, Nasser G, Vidaud D, Riant F, Tournier Lasserve E, et al. Occurrence of multiple Cerebral Cavernous Malformations in a patient with Neurofibromatosis type 1. J Neurol Sci. 2015;350:98-100 pubmed publisher
    ..Screening of CCM1, CCM2 and CCM3 genes was negative while a deleterious frameshift mutation was identified in NF1 gene...
  17. Han J, Puri R. Analysis of the cancer genome atlas (TCGA) database identifies an inverse relationship between interleukin-13 receptor α1 and α2 gene expression and poor prognosis and drug resistance in subjects with glioblastoma multiforme. J Neurooncol. 2018;136:463-474 pubmed publisher
    ..In depth analysis of TCGA data revealed that immunosuppressive genes (such as FMOD, CCL2, OSM, etc.) were highly expressed in IL-13Rα2 positive tumors, but not in IL-13Rα2 negative tumors...
  18. Su C, Chiang Y, Huang C, Hsu C, Fong Y, Tang C. Osteopontin Promotes Oncostatin M Production in Human Osteoblasts: Implication of Rheumatoid Arthritis Therapy. J Immunol. 2015;195:3355-64 pubmed publisher
    ..This study evaluated the activation of oncostatin M (OSM) by OPN in human primary osteoblasts to understand RA pathogenesis and characterized the intracellular signaling ..
  19. Charron C, Dawson H, Albaugh G, Solverson P, Vinyard B, Solano Aguilar G, et al. A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans. J Nutr. 2015;145:2448-55 pubmed publisher
    ..T cells (NFAT) activating protein with immunoreceptor tyrosine-based activation motif 1 (NFAM1), oncostatin M (OSM), and V-rel avian reticuloendotheliosis viral oncogene homolog (REL)...
  20. Strålberg F, Kassem A, Kasprzykowski F, Abrahamson M, Grubb A, Lindholm C, et al. Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors. J Leukoc Biol. 2017;101:1233-1243 pubmed publisher
    ..gene encoding TNF-?; Tnfsf2) mRNA expression without affecting Il1b, Il6, or oncostatin M (Osm) expression. Formation of osteoclasts in the skull bones after local LPS stimulation was inhibited by E-64...
  21. Sun Y, Kuek V, Qiu H, Tickner J, Chen L, Wang H, et al. The emerging role of NPNT in tissue injury repair and bone homeostasis. J Cell Physiol. 2018;233:1887-1894 pubmed publisher
    ..factors such as tumor necrosis factor alpha (TNF-?), transforming growth factor beta (TGF-?), oncostatin M (OSM), bone morphogenic protein 2 (BMP2), Wnt3a, Vitamin D3 , and microRNA-378 (miR378)...
  22. Dunnington L, Nakagawa M. Fast and safe gas detection from underground coal fire by drone fly over. Environ Pollut. 2017;229:139-145 pubmed publisher
    ..S. Department of the Interior's Office of Surface Mining Remediation and Enforcement (OSM), exceeds $1 billion...
  23. Rinaldi C, Bramanti P, Famà A, Scimone C, Donato L, Antognelli C, et al. GLYOXALASE I A111E, PARAOXONASE 1 Q192R AND L55M POLYMORPHISMS IN ITALIAN PATIENTS WITH SPORADIC CEREBRAL CAVERNOUS MALFORMATIONS: A PILOT STUDY. J Biol Regul Homeost Agents. 2015;29:493-500 pubmed
    ..penetrance and variable clinical expression attributable to mutations in three different genes: CCM1(Krit1), CCM2 (MGC4607) and CCM3 (PDCD10)...
  24. Rana U, Liu Z, Kumar S, Zhao B, Hu W, Bordas M, et al. Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. Dev Biol. 2016;410:190-201 pubmed publisher
    ..endothelial cell migration by abolishing Akt phosphorylation, but also decreases the expression of CCM1 and CCM2 proteins...
  25. Couderc E, Morel F, Levillain P, Buffiere Morgado A, Camus M, Paquier C, et al. Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis. PLoS ONE. 2017;12:e0181486 pubmed publisher
    ..NHEK were stimulated by A-SAA or the cytokines IL-1?, IL-17A, IL-22, OSM, TNF-? alone or in combination, previously reported to reproduce features of psoriasis...
  26. Ni K, Umair Mukhtar Mian M, Meador C, Gill A, Barwinska D, Cao D, et al. Oncostatin M and TNF-α Induce Alpha-1 Antitrypsin Production in Undifferentiated Adipose Stromal Cells. Stem Cells Dev. 2017;26:1468-1476 pubmed publisher
    ..nonsmoking or smoking donors were stimulated by inflammatory cytokines tumor necrosis alpha (TNFα), oncostatin M (OSM), and/or dexamethasone (DEX) or were exposed to sublethal concentrations of ambient air control or CS extract (0...
  27. Esnault S, Bernau K, Torr E, Bochkov Y, Jarjour N, Sandbo N. RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism. Respir Res. 2017;18:188 pubmed publisher
    ..This analysis combined with previous RNA sequencing analyses of eosinophils suggest IL-1ß, OSM and TNFSF12 as potential upstream regulators of fibroblasts...
  28. Taranu I, Marin D, Braicu C, Pistol G, Sorescu I, Pruteanu L, et al. In Vitro Transcriptome Response to a Mixture of Lactobacilli Strains in Intestinal Porcine Epithelial Cell Line. Int J Mol Sci. 2018;19: pubmed publisher
    ..i>clade A member 3 (SERPINA 3), interleukin-20 (IL-20), oncostatin M(OSM), granulocyte-macrophage colony-stimulating factor (GM-CSF), and the suppression of chemokine (..
  29. Snelling S, Davidson R, Swingler T, Le L, Barter M, Culley K, et al. Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role. Osteoarthritis Cartilage. 2016;24:883-91 pubmed publisher
    ..analysed by incubation of bovine and human cartilage explants with interleukin-1β (IL1β) and oncostatin-M (OSM). Dkk3 gene expression was measured in cartilage following murine hip avulsion...
  30. Spiegler S, Kirchmaier B, Rath M, Korenke G, Tetzlaff F, van de Vorst M, et al. FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations. Mol Syndromol. 2016;7:144-52 pubmed publisher
    ..inherited CCMs were found to be associated with heterozygous inactivating mutations in 3 genes, CCM1 (KRIT1), CCM2 (MGC4607), and CCM3 (PDCD10) in 1999, 2003 and 2005, respectively...
  31. Wang H, Pan Y, Zhang Z, Li X, Xu Z, Suo Y, et al. A Novel KRIT1/CCM1 Gene Insertion Mutation Associated with Cerebral Cavernous Malformations in a Chinese Family. J Mol Neurosci. 2017;61:221-226 pubmed publisher
    ..FCCM) is a vascular malformation disorder that closely associated with three identified genes: KRIT1/CCM1, MGC4607/CCM2, and PDCD10/CCM3. Here, we present a Chinese family affected by FCCM due to a novel KRIT1/CCM1 insertion mutation...
  32. Herberich S, Klose R, Moll I, Yang W, Wüstehube Lausch J, Fischer A. ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis. PLoS ONE. 2015;10:e0145304 pubmed publisher
    ..fragile blood vessel conglomerates in the central nervous system that are caused by mutations in the CCM1/KRIT1, CCM2 or CCM3 genes...
  33. Wu R, Wang W, Huang G, Mao X, Chen Y, Tang Q, et al. Endothelin‑1 induces oncostatin M expression in osteoarthritis osteoblasts by trans‑activating the oncostatin M gene promoter via Ets‑1. Mol Med Rep. 2016;13:3559-66 pubmed publisher
    Oncostatin M (OSM) contributes to cartilage degeneration in osteoarthritis (OA) and was demonstrated to be expressed in OA osteoblasts...
  34. Fan X, Hughes B, Ali M, Chan B, Launier K, Schulz R. Matrix metalloproteinase-2 in oncostatin M-induced sarcomere degeneration in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2016;311:H183-9 pubmed publisher
    ..Cardiomyocyte dedifferentiation and proliferation induced by oncostatin-M (OSM) is characterized by sarcomere degeneration...
  35. Khansai M, Boonmaleerat K, Pothacharoen P, Phitak T, Kongtawelert P. Ex vivo model exhibits protective effects of sesamin against destruction of cartilage induced with a combination of tumor necrosis factor-alpha and oncostatin M. BMC Complement Altern Med. 2016;16:205 pubmed publisher
    Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammatory arthritis. TNF-? and OSM are pro-inflammatory cytokines that play a key role in RA progression...
  36. Scharschmidt T. Measuring inflammation in IBD with an OSM-ostat. Sci Transl Med. 2017;9: pubmed publisher
    ..Oncostatin M is elevated in inflammatory bowel disease, wherein it may promote intestinal stroma cell inflammation and predict nonresponsiveness to anti-TNF therapy. ..
  37. Donat S, Lourenço M, Paolini A, Otten C, Renz M, Abdelilah Seyfried S. Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis. elife. 2018;7: pubmed publisher
    ..CCM) is an inherited vascular disease that occurs when a second somatic mutation causes a loss of CCM1/KRIT1, CCM2, or CCM3 proteins. Here, we demonstrate that zebrafish Krit1 regulates the formation of cardiac valves...
  38. Goyden J, Tawara K, Hedeen D, Willey J, Oxford J, Jorcyk C. The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation. PLoS ONE. 2015;10:e0127230 pubmed publisher
    ..Our lab and others have shown that the IL-6 class cytokine oncostatin M (OSM) is an important regulator of bone remodeling...
  39. Miller M, Beppu A, Rosenthal P, Pham A, Das S, Karta M, et al. Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M. J Immunol. 2015;195:3546-56 pubmed publisher
    ..in macrophages/myeloid cells had significantly reduced airway remodeling and reduced levels of oncostatin M (OSM), a cytokine previously not known to be regulated by Fstl1...
  40. Bravi L, Malinverno M, Pisati F, Rudini N, Cuttano R, Pallini R, et al. Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition. Stroke. 2016;47:886-90 pubmed publisher
    ..have an inherited form of the disease with ubiquitous loss-of-function mutation in any one of 3 genes CCM1, CCM2, and CCM3...
  41. Gorenec L, Zidovec Lepej S, Grgić I, Planinic A, Iscic Bes J, Vince A, et al. The comparison of Th1, Th2, Th9, Th17 and Th22 cytokine profiles in acute and chronic HIV-1 infection. Microb Pathog. 2016;97:125-30 pubmed publisher
    ..statistically significant increase of 13 cytokine gene expression (cd40lg, csf2, ifna5, il12b, il1b, il20, lta, osm, spp1, tgfa, tnfsf 11, 14 and 8) and downregulation of the il12a expression in chronic HIV type 1 infection...
  42. Mukherjee S, Sengupta Bandyopadhyay S. Phorbol-12-myristate-13-acetate (PMA) mediated transcriptional regulation of Oncostatin-M. Cytokine. 2016;88:209-213 pubmed publisher
    Oncostatin-M (OSM), an IL-6 family cytokine, exhibits varied roles in different patho-physiological conditions. Differential expression of OSM in response to varying stimuli indicates importance of its regulation of expression...
  43. Bottai G, Diao L, Baggerly K, Paladini L, Gyorffy B, Raschioni C, et al. Integrated MicroRNA-mRNA Profiling Identifies Oncostatin M as a Marker of Mesenchymal-Like ER-Negative/HER2-Negative Breast Cancer. Int J Mol Sci. 2017;18: pubmed publisher
    ..between miRNA and mRNA data revealed the importance of immune-related pathways, particularly the Oncostatin M (OSM) signaling, associated with mesenchymal-like breast cancer cells...
  44. Mosca L, Pileggi S, Avemaria F, Tarlarini C, Cigoli M, Capra V, et al. De novo MGC4607 gene heterozygous missense variants in a child with multiple cerebral cavernous malformations. J Mol Neurosci. 2012;47:475-80 pubmed publisher
  45. Wang X, Ding J, Wang D. Crystallization and preliminary X-ray analysis of the C-terminal domain of CCM2, part of a novel adaptor protein involved in cerebral cavernous malformations. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:683-6 pubmed publisher
    b>Cerebral cavernous malformation 2 (CCM2) is a novel two-domain adaptor protein which participates in multiple cellular signalling pathways...
  46. McKenzie A, Muñoz C, Ellis L, Perrier E, Guelinckx I, Klein A, et al. Urine color as an indicator of urine concentration in pregnant and lactating women. Eur J Nutr. 2017;56:355-362 pubmed publisher
    Urine concentration measured via osmolality (U OSM) and specific gravity (U SG) reflects the adequacy of daily fluid intake, which has important relationships to health in pregnant (PREG) and lactating (LACT) women...
  47. Park K, Lin C, Benveniste E, Lee Y. Mitochondrial STAT3 is negatively regulated by SOCS3 and upregulated after spinal cord injury. Exp Neurol. 2016;284:98-105 pubmed publisher
    ..Immunoblot analyses demonstrated that Oncostatin M (OSM), a member of the interleukin-6 (IL-6) cytokine family, induced both P-STAT3 Tyr and P-STAT3 Ser in SH-SY5Y cells...
  48. Bryson B, Junk D, Cipriano R, Jackson M. STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle. 2017;16:319-334 pubmed publisher
    ..Elevated levels of the Interleukin-6 (IL-6) family cytokine Oncostatin M (OSM) in the breast TME correlate with aggressive, metastatic cancers, increased tumor recurrence, and poor patient ..
  49. Hariharan V, Denton T, Paraszcszak S, McEvoy K, Jeitner T, Krasnikov B, et al. The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites. Biology (Basel). 2017;6: pubmed publisher
    ..Previous work showed that 2-oxosuccinamate (2-OSM; transamination product of l-asparagine) is an excellent substrate of LDH...
  50. Jiang L, Tam B, Ying G, Wu S, Hauswirth W, Frederick J, et al. Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function. FASEB J. 2015;29:4866-80 pubmed publisher
    In Caenorhabditis elegans, homodimeric [kinesin family (KIF) 17, osmotic avoidance abnormal-3 (OSM-3)] and heterotrimeric (KIF3) kinesin-2 motors are required to establish sensory cilia by intraflagellar transport (IFT) where KIF3 and ..
  51. Yaba A, Ordueri N, Tanriover G, Sahin P, Demir N, Celik Ozenci C. Expression of CCM2 and CCM3 during mouse gonadogenesis. J Assist Reprod Genet. 2015;32:1497-507 pubmed publisher
    Three cerebral cavernous malformation (CCM) proteins, CCM1, CCM2, and CCM3, regulate cell-cell adhesion, cell shape and polarity, and most likely cell adhesion to extracellular matrix...
  52. Retta S, Glading A. Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin. Int J Biochem Cell Biol. 2016;81:254-270 pubmed publisher
    ..are emerging from a growing understanding of the biological functions of the three known CCM proteins, CCM1/KRIT1, CCM2 and CCM3/PDCD10...
  53. Smigiel J, Parameswaran N, Jackson M. Potent EMT and CSC Phenotypes Are Induced By Oncostatin-M in Pancreatic Cancer. Mol Cancer Res. 2017;15:478-488 pubmed publisher
    ..Here, oncostatin M (OSM), an IL6 cytokine family member, was identified as an important driver of mesenchymal and cancer stem cell (CSC) ..
  54. Silva M, Morsci N, Nguyen K, Rizvi A, Rongo C, Hall D, et al. Cell-Specific ?-Tubulin Isotype Regulates Ciliary Microtubule Ultrastructure, Intraflagellar Transport, and Extracellular Vesicle Biology. Curr Biol. 2017;27:968-980 pubmed publisher
    ..CEM cilia, tba-6 regulates velocities and cargoes of intraflagellar transport (IFT) kinesin-2 motors kinesin-II and OSM-3/KIF17 without affecting kinesin-3 KLP-6 motility...
  55. Labauge P, Krivosic V, Denier C, Tournier Lasserve E, Gaudric A. Frequency of retinal cavernomas in 60 patients with familial cerebral cavernomas: a clinical and genetic study. Arch Ophthalmol. 2006;124:885-6 pubmed
    ..To define the frequency of retinal lesions in a large panel of patients with familial cerebral cavernomas and to screen the cerebral cavernous malformation genes in patients with cerebral and retinal lesions...
  56. Harrison G, Rajsic J, Wilson D. Object-substitution masking degrades the quality of conscious object representations. Psychon Bull Rev. 2016;23:180-6 pubmed publisher
    Object-substitution masking (OSM) is a unique paradigm for the examination of object updating processes...
  57. Nair M, Suman S, Chatli M, Li S, Joseph P, Beach C, et al. Proteome basis for intramuscular variation in color stability of beef semimembranosus. Meat Sci. 2016;113:9-16 pubmed publisher
    ..54-cm thick color-labile inside (ISM) and color-stable outside (OSM) steaks...
  58. Ko H, Park B, Choi S, Kang H, Kim A, Kim H, et al. STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J. 2016;57:761-8 pubmed publisher
    Our previous studies have shown that oncostatin M (OSM) promotes trophoblast invasion activity through increased enzyme activity of matrix metalloproteinase (MMP)-2 and -9...
  59. Liu L, Wada H, Matsubara N, Hozumi K, Itoh M. Identification of Domains for Efficient Notch Signaling Activity in Immobilized Notch Ligand Proteins. J Cell Biochem. 2017;118:785-796 pubmed publisher
    ..In addition, we found that reconstruction of the DLL4 delta and OSM-11 (DOS) motif (N257P) resulted in an increase in both binding affinity and signaling activity, which suggests that ..
  60. Sterbova S, Karlsson T, Persson E. Oncostatin M induces tumorigenic properties in non-transformed human prostate epithelial cells, in part through activation of signal transducer and activator of transcription 3 (STAT3). Biochem Biophys Res Commun. 2018;498:769-774 pubmed publisher
    ..Here we show that the IL-6-type cytokine oncostatin M (OSM) indeed induce cellular properties associated with tumorigenesis and disease progression in non-transformed human ..
  61. Scimone C, Bramanti P, Ruggeri A, Katsarou Z, Donato L, Sidoti A, et al. Detection of Novel Mutation in Ccm3 Causes Familial Cerebral Cavernous Malformations. J Mol Neurosci. 2015;57:400-3 pubmed publisher
    ..Causes of familial forms are mutations at three loci: CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10. Here, we describe a novel CCM3 missense mutation (c...
  62. Li X, Fisher O, Boggon T. The cerebral cavernous malformations proteins. Oncotarget. 2015;6:32279-80 pubmed publisher
  63. Tolkin T, Christiaen L. Rewiring of an ancestral Tbx1/10-Ebf-Mrf network for pharyngeal muscle specification in distinct embryonic lineages. Development. 2016;143:3852-3862 pubmed
    ..which control the exhalant and inhalant siphons, respectively, also requires Mrf We characterize the ontogeny of OSM progenitors and compare the molecular basis of Mrf activation in OSM versus ASM...
  64. Rinaldi C, Bramanti P, Scimone C, Donato L, Alafaci C, D Angelo R, et al. Relevance of CCM gene polymorphisms for clinical management of sporadic cerebral cavernous malformations. J Neurol Sci. 2017;380:31-37 pubmed publisher
    ..They occur in both sporadic and inherited autosomal dominant form. Germline mutations in CCM1, CCM2 and CCM3 were identified in familial cases...
  65. Tonelli A, Lanfranconi S, Bersano A, Corti S, Bassi M, Bresolin N. Aberrant splicing due to a silent nucleotide change in CCM2 gene in a family with cerebral cavernous malformation. Clin Genet. 2009;75:494-7 pubmed
  66. Draheim K, Li X, Zhang R, Fisher O, Villari G, Boggon T, et al. CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. J Cell Biol. 2015;208:987-1001 pubmed publisher
    Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous malformations (CCM), vascular lesions that most frequently occur in the brain and are strongly associated with hemorrhagic stroke, seizures, and other ..
  67. Yanpeng W, Qiongxiao H, Sheng X, Jing S. [Establishment of mouse endometrial injury model by curettage or coagulation]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017;46:186-191 pubmed
    ..The expressions of leukemia inhibitory factor (LIF) and oncostatin M (OSM) were significantly reduced on injured side in both groups compared to opposite side; however, the expression of ..
  68. Chang R, Yi S, Tan X, Huang Y, Wang Q, Su G, et al. MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease. Br J Ophthalmol. 2018;102:282-290 pubmed publisher
    ..The two genes, oncostatin M (OSM) and C-C motif chemokine ligand 1 (CCL1), were identified as targets of miR-20a-5p...
  69. Pellitero S, Piquer Garcia I, Ferrer Curriu G, Puig R, Martinez E, Moreno P, et al. Opposite changes in meteorin-like and oncostatin m levels are associated with metabolic improvements after bariatric surgery. Int J Obes (Lond). 2018;42:919-922 pubmed publisher
    ..Here we studied the effects of bariatric surgery on circulating meteorin-like (Metrnl) and oncostatin m (OSM) levels, two hormones intimately linked to energy homeostasis...
  70. Costa B, Kean M, Ast V, Knight J, Mett A, Levy Z, et al. STK25 protein mediates TrkA and CCM2 protein-dependent death in pediatric tumor cells of neural origin. J Biol Chem. 2012;287:29285-9 pubmed publisher
    The TrkA receptor tyrosine kinase induces death in medulloblastoma cells via an interaction with the cerebral cavernous malformation 2 (CCM2) protein...
  71. Haghighi A, Fathi D, Shahbazi M, Motahari M, Friedman B. Identification of a c.601C>G mutation in the CCM1 gene in a kindred with multiple skin, spinal and cerebral cavernous malformations. J Neurol Sci. 2013;334:97-101 pubmed publisher
    ..manner with incomplete penetrance and variable expression, are attributed to mutations in three genes, CCM1, CCM2 and CCM3...
  72. Cigoli M, De Benedetti S, Marocchi A, Bacigaluppi S, Primignani P, Gesu G, et al. A Novel MGC4607/CCM2 Gene Mutation Associated with Cerebral Spinal and Cutaneous Cavernous Angiomas. J Mol Neurosci. 2015;56:602-7 pubmed publisher
    ..Three genes have been identified as causing familial CCM: KRIT1/CCM1, MGC4607/CCM2, and PDCD10/CCM3, mapping, respectively, on chromosomes 7q, 7p, and 3q...
  73. Du L, Yamamoto S, Burnette B, Huang D, Gao K, Jamshidi N, et al. Transcriptome profiling reveals novel gene expression signatures and regulating transcription factors of TGFβ-induced epithelial-to-mesenchymal transition. Cancer Med. 2016;5:1962-72 pubmed publisher
    ..After 7 days of TGF-beta/Oncostatin M (OSM) treatment, changes in cell morphology to a mesenchymal phenotype were observed as well as concordant EMT-..
  74. Filmer H, Wells Peris R, Dux P. The role of executive attention in object substitution masking. Atten Percept Psychophys. 2017;79:1070-1077 pubmed publisher
    It was long thought that a key characteristic of object substitution masking (OSM) was the requirement for spatial attention to be dispersed for the mask to impact visual sensitivity...
  75. Huang H, Zhu C, Skuja L, Hayden D, Hart A. Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep. G3 (Bethesda). 2017;7:2907-2917 pubmed publisher
    ..efficiency, we first looked for mutations that suppressed inappropriate anachronistic sleep in adult hsp::osm-11 animals overexpressing the Notch coligand OSM-11 after heat shock...
  76. Rani J, Mittal I, Pramanik A, Singh N, Dube N, Sharma S, et al. T2DiACoD: A Gene Atlas of Type 2 Diabetes Mellitus Associated Complex Disorders. Sci Rep. 2017;7:6892 pubmed publisher
    ..A few genes ACE2, ADCYAP1, HDAC4, NCF1, NFE2L2, OSM, SMAD1, TGFB1, BDNF, SYVN1, TXNIP, CD36, CYP2J2, NLRP3 with details of protective role are catalogued...
  77. Tanriover G, Seval Y, Sati L, Gunel M, Demir N. CCM2 and CCM3 proteins contribute to vasculogenesis and angiogenesis in human placenta. Histol Histopathol. 2009;24:1287-94 pubmed publisher
    ..Three CCM loci have been mapped as Ccm1, Ccm2, Ccm3 genes in CCM...
  78. D Angelo R, Scimone C, Calabrò M, Schettino C, Fratta M, Sidoti A. Identification of a novel CCM2 gene mutation in an Italian family with multiple cerebral cavernous malformations and epilepsy: a causative mutation?. Gene. 2013;519:202-7 pubmed publisher
    ..This truncates the mutant CCM2 gene protein, the malcavernin, to 233 amino acids, respect to 444 amino acids of the wild-type malcavernin...
  79. Bager C, Gudmann N, Willumsen N, Leeming D, Karsdal M, Bay Jensen A, et al. Quantification of fibronectin as a method to assess ex vivo extracellular matrix remodeling. Biochem Biophys Res Commun. 2016;478:586-91 pubmed publisher
    ..When ex vivo cartilage cultures were stimulated with the anabolic factor TGF? and catabolic factors TNF-? and OSM, significantly higher levels of FBN-C were found in the conditioned media...
  80. Zheng X, Riant F, Bergametti F, Myers C, Tang A, Kleaveland B, et al. Cerebral cavernous malformations arise independent of the heart of glass receptor. Stroke. 2014;45:1505-1509 pubmed publisher
    The Heart of Glass (HEG) receptor binds KRIT1 and functions with KRIT1, CCM2, and PDCD10 in a common signaling pathway required for heart and vascular development...
  81. Torossian F, Guerton B, Anginot A, Alexander K, Desterke C, Soave S, et al. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017;2: pubmed publisher
    ..We demonstrate that oncostatin M (OSM) produced by activated macrophages promotes osteoblastic differentiation and mineralization of human muscle-derived ..
  82. Komori T, Morikawa Y. Oncostatin M in the development of metabolic syndrome and its potential as a novel therapeutic target. Anat Sci Int. 2018;93:169-176 pubmed publisher
    Oncostatin M (OSM), a member of the IL-6 family of cytokines, plays an important role in various biologic actions, including cell growth, neuronal development, and inflammatory responses...
  83. Duong H, Kim N, Thambi T, Giang Phan V, Lee M, Yin Y, et al. Microneedle arrays coated with charge reversal pH-sensitive copolymers improve antigen presenting cells-homing DNA vaccine delivery and immune responses. J Control Release. 2018;269:225-234 pubmed publisher
    ..reversal pH-responsive copolymer, composed of oligo(sulfamethazine)-b-poly(ethylene glycol)-b-poly(amino urethane) (OSM-b-PEG-b-PAEU), was used as a triggering layer in the polyelectrolyte multilayer assembly on microneedles...
  84. Pileggi S, Buscone S, Ricci C, Patrosso M, Marocchi A, Brunori P, et al. Genetic variations within KRIT1/CCM1, MGC4607/CCM2 and PDCD10/CCM3 in a large Italian family harbouring a Krit1/CCM1 mutation. J Mol Neurosci. 2010;42:235-42 pubmed publisher
    ..The genes responsible for this disease are KRIT1/CCM1 on chromosome 7q21.2, MGC4607/CCM2 on chromosome 7p15-p13 and PDCD10/CCM3 on chromosome 3q25.2-q27...
  85. Fisher O, Zhang R, Li X, Murphy J, Demeler B, Boggon T. Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus. FEBS Lett. 2013;587:272-7 pubmed publisher
    ..5% of the population. Mutations in the CCM2 gene are associated with acquisition of CCM...
  86. Miura K, Nojiri T, Akitake Y, Ando K, Fukuhara S, Zenitani M, et al. CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading. Biochem J. 2017;474:1897-1918 pubmed publisher
    ..p21-activated kinase 4 (PAK4) and cerebral cavernous malformations 2 (CCM2), a scaffold protein involved in a cerebrovascular disease, were required for the phosphorylation of MLC and ..
  87. Noe B, Poole A, Mort J, Richard H, Beauchamp G, Laverty S. C2K77 ELISA detects cleavage of type II collagen by cathepsin K in equine articular cartilage. Osteoarthritis Cartilage. 2017;25:2119-2126 pubmed publisher
    ..explants with or without stimulation by interleukin-1 beta (IL-1?), tumour necrosis-alpha (TNF-?), oncostatin M (OSM) and lipopolysaccharide (LPS)...
  88. Holmstrup M, Slotsbo S. Combined effects of drought and cold acclimation on phospholipid fatty acid composition and cold-shock tolerance in the springtail Protaphorura fimata. J Comp Physiol B. 2018;188:225-236 pubmed publisher
    ..Acclimation to mild drought (- 2.46 MPa) increased body fluid osmolality from 0.33 to 1.25 Osm at all acclimation temperatures (5, 10, 15, or 20 °C) likely due to accumulation of the compatible osmolytes, ..
  89. Zhuo C, Liang L, Zhao Y, Guo Z, Lu S. A cold responsive ERF from Medicago falcata confers cold tolerance by up-regulation of polyamine turnover, antioxidant protection and proline accumulation. Plant Cell Environ. 2017;: pubmed publisher
    ..Higher transcript levels of some stress responsive genes (CHN50, OSM, ERD10C, and SAMS) and those involved in spermidine (Spd) and spermine (Spm) synthesis (SAMDC1, SAMDC2, SPDS1, ..
  90. De Silvestro A, Martini K, Becker A, Kim Nguyen T, Guggenberger R, Calcagni M, et al. Postoperative imaging of orthopaedic hardware in the hand and wrist: is there an added value for tomosynthesis?. Clin Radiol. 2018;73:214.e1-214.e9 pubmed publisher
    ..was higher for DTS compared to DR, especially for fracture-related parameters (delineation osteosynthesis material [OSM]: KDTS0.96 versus KDR0.45; delineation fracture margins: KDTS0...
  91. Katsoufi S, Lazou A, Giannakourou M, Krokida M. Mass transfer kinetics and quality attributes of osmo-dehydrated candied pumpkins using nutritious sweeteners. J Food Sci Technol. 2017;54:3338-3348 pubmed publisher
    ..The process temperature (Tosm ) had a significant effect on the water loss and solid gain as well as on the physiochemical ..