CCL23

Summary

Gene Symbol: CCL23
Description: C-C motif chemokine ligand 23
Alias: CK-BETA-8, CKb8, Ckb-8, Ckb-8-1, MIP-3, MIP3, MPIF-1, SCYA23, hmrp-2a, C-C motif chemokine 23, C6 beta-chemokine, chemokine (C-C motif) ligand 23, macrophage inflammatory protein 3, myeloid progenitor inhibitory factor 1, small inducible cytokine subfamily A (Cys-Cys), member 23
Species: human
Products:     CCL23

Top Publications

  1. Forssmann U, Delgado M, Uguccioni M, Loetscher P, Garotta G, Baggiolini M. CKbeta8, a novel CC chemokine that predominantly acts on monocytes. FEBS Lett. 1997;408:211-6 pubmed
  2. Macphee C, Appelbaum E, Johanson K, Moores K, Imburgia C, Fornwald J, et al. Identification of a truncated form of the CC chemokine CK beta-8 demonstrating greatly enhanced biological activity. J Immunol. 1998;161:6273-9 pubmed
    ..However, in contrast to its action on monocytes, CKbeta-8 was a very poor chemotactic factor for eosinophils. ..
  3. Miao Z, Premack B, Wei Z, Wang Y, Gerard C, Showell H, et al. Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23. J Immunol. 2007;178:7395-404 pubmed
    ..However, a single chemokine protein, a processed form of the alternatively spliced CCL23 (CKbeta8/MPIF-1) gene product, potently engages both the "classical" chemokine receptor CCR1, as well as ..
  4. Berahovich R, Miao Z, Wang Y, Premack B, Howard M, Schall T. Proteolytic activation of alternative CCR1 ligands in inflammation. J Immunol. 2005;174:7341-51 pubmed
    ..protein-1, CCL9/MIP-1gamma/MIP-related protein-2, CCL15/MIP-1delta/hemofiltrate CC chemokine-2/leukotactin-1, and CCL23/CKbeta8/myeloid progenitor inhibitory factor-1, are unique in possessing a separately encoded N-terminal domain of ..
  5. Wang L, Zhi K, Zhang Y, Liu Y, Zhang L, Yasin A, et al. Molecularly Imprinted Polymers for Gossypol via Sol⁻Gel, Bulk, and Surface Layer Imprinting-A Comparative Study. Polymers (Basel). 2019;11: pubmed publisher
    ..polymerization (MIP1), surface layer imprinting using silica gel as the support (MIP2), and the sol-gel process (MIP3)...
  6. Chen P, Zhong Z, Jiang H, Chen H, Lyu J, Zhou L. Th17-associated cytokines multiplex testing indicates the potential of macrophage inflammatory protein-3 alpha in the diagnosis of biliary atresia. Cytokine. 2019;116:21-26 pubmed publisher
    ..The diagnostic value of MIP3a was further confirmed in our validation study. MIP3a alone or combined with other laboratory data would significantly increase the diagnostic accuracy of BA. ..
  7. Lareyre F, Moratal C, Chikande J, Jean Baptiste E, Hassen Khodja R, Neels J, et al. Investigation of Plasma Inflammatory Profile in Diabetic Patients With Abdominal Aortic Aneurysm: A Pilot Study. Vasc Endovascular Surg. 2018;52:597-601 pubmed publisher
    ..patients had significantly lower protein expression of C-C motif chemokine 19 (CCL19) and C-C motif chemokine 23 (CCL23; 542.3 vs 980.3, P = .01 and 1236 vs 1406, P = .04, respectively)...
  8. Jayeshbhai C, Hajam I, Verma A, Bhanuprakash V, Kondabattula G, Kishore S. Chemokine CCL20 plasmid improves protective efficacy of the Montanide ISA™ 206 adjuvanted foot-and-mouth disease vaccine in mice model. Vaccine. 2018;36:5318-5324 pubmed publisher
  9. Timasheva Y, Nasibullin T, Tuktarova I, Erdman V, Mustafina O. CXCL13 polymorphism is associated with essential hypertension in Tatars from Russia. Mol Biol Rep. 2018;45:1557-1564 pubmed publisher
    ..Genotyping of polymorphic markers in six chemokine genes (CXCL13, CCL8, CCL16, CCL17, CCL18, and CCL23) was performed in the group of 522 men of Tatar ethnic origin from the Republic of Bashkortostan, Russia (213 ..

More Information

Publications75

  1. Laudanski P, Zbucka Kretowska M, Charkiewicz K, Wolczynski S, Wojcik D, Charkiewicz R. Maternal plasma and amniotic fluid chemokines screening in fetal Down syndrome. Mediators Inflamm. 2014;2014:835837 pubmed publisher
    ..Defining their potential as biochemical markers of Down syndrome requires further investigation on larger group of patients. ..
  2. Yang X, Zhang H, Shang J, Liu G, Xia T, Zhao C, et al. Comparative analysis of the blood transcriptomes between wolves and dogs. Anim Genet. 2018;49:291-302 pubmed publisher
    ..Six differentially expressed genes related to the innate immune response (CCL23, TRIM10, DUSP10, RAB27A, CLEC5A and GCH1) were found in the wolf by a Gene Ontology enrichment analysis...
  3. Chu X, Jin Q, Chen H, Wood G, Petrick A, Strodel W, et al. CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading. J Transl Med. 2018;16:108 pubmed publisher
    ..These data also point to hepatic stellate cells as a key cell type that may respond to lipid loading of the liver. ..
  4. Ko T, Kuo H, Chang J, Chen S, Liu Y, Chen H, et al. CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease. Circ Res. 2015;116:876-83 pubmed publisher
    ..phase (n [KD]=37; n [control]=20), the expression of interleukin-17F, sCD40L, E-selectin, CCL23 (myeloid progenitor inhibitory factor 1), and CXCL10 (IFN-γ-inducible protein 10 [IP-10]) were upregulated during the acute phase in ..
  5. Yi G, Liang M, Li M, Fang X, Liu J, Lai Y, et al. A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells. Inflamm Res. 2018;67:539-551 pubmed publisher
    ..Among the most up-regulated genes were IL1B, CCL2, CCL23, and CXCL14, all implicated in inflammation triggering...
  6. Zhang Y, Qian Y, Si Y, Bao H, Zhou J. [Differential expressions of serum cytokines in cognitive dysfunction patients after colorectal surgery]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:231-4 pubmed
    ..Fas, methyl-accepting chemotaxis protein 3 (MCP3), myeloid progenitor inhibitory factor-1 (MPIF-1), macrophage inflammatory protein 3 alpha (MIP-3α), brain-derived neurotrophic factor (BDNF) were determined by ELISA...
  7. Oberlin D, McGuire B, Pilecki M, Rambachan A, Kim J, Perry K, et al. Contemporary national surgical outcomes in the treatment of ureteropelvic junction obstruction. Urology. 2015;85:363-7 pubmed publisher
    ..2). Within the American College of Surgeons National Surgical Quality Improvement Program hospitals, MIP is associated with decreased reoperation and postoperative morbidity compared with OP. ..
  8. Steinbach D, Bader P, Willasch A, Bartholomae S, Debatin K, Zimmermann M, et al. Prospective validation of a new method of monitoring minimal residual disease in childhood acute myelogenous leukemia. Clin Cancer Res. 2015;21:1353-9 pubmed publisher
    ..The expression of seven leukemia-associated genes (WT1, PRAME, CCL23, GAGED2, MSLN, SPAG6, and ST18) was measured by TaqMan Low Density Arrays in 112 patients and 52 healthy controls...
  9. Inada N, Ishimori A, Shoji J. CCL20/MIP-3 alpha mRNA expression in the conjunctival epithelium of normal individuals and patients with vernal keratoconjunctivitis. Graefes Arch Clin Exp Ophthalmol. 2014;252:1977-84 pubmed publisher
    ..001, Spearman's rank correlation coefficient), but not eotaxin-2. We conclude that CCL 20 mRNA expression in the conjunctival epithelium plays a crucial role in regulating homeostasis at the ocular surface and in exacerbation of VKC. ..
  10. Gölz L, Buerfent B, Hofmann A, Hübner M, Rühl H, Fricker N, et al. Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases. Innate Immun. 2016;22:72-84 pubmed publisher
    ..Besides known periodontitis-associated targets, several new candidates were identified (CCL23↑, INDO↑, GBP 1/4↑, CFB↑, ISG20↑, MIR155HG↑, DHRS9↓)...
  11. Fleischmann R, Wagner F, Kivitz A, Mansikka H, Khan N, Othman A, et al. Safety, Tolerability, and Pharmacodynamics of ABT-122, a Tumor Necrosis Factor- and Interleukin-17-Targeted Dual Variable Domain Immunoglobulin, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017;69:2283-2291 pubmed publisher
    ..The levels of CXCL9, CXCL10, CCL23, and soluble E-selectin were significantly decreased following ABT-122 treatment relative to placebo treatment...
  12. Siwach P, Gill A. Micropropagation of Ficus religiosa L. via leaf explants and comparative evaluation of acetylcholinesterase inhibitory activity in the micropropagated and conventionally grown plants. 3 Biotech. 2014;4:477-491 pubmed publisher
    ..87, 72.91, 67.65 and 69.65 ?g/ml, respectively. ..
  13. Rump L, Mattey D, Kehoe O, Middleton J. An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine. 2017;97:133-140 pubmed publisher
    ..chemokines shown to be present in RA ECs were CCL1-3, CCL5, CCL10-13, CCL15, CCL17, CCL18, CCL20, CCL21 and CCL23-28. In conclusion, this initial study is the first to show the presence of a number of CC chemokines in RA ECs...
  14. Kang Y, Zhu Z, Zheng Y, Wan W, Manole C, Zhang Q. Skin telocytes versus fibroblasts: two distinct dermal cell populations. J Cell Mol Med. 2015;19:2530-9 pubmed publisher
    ..5 times higher (results also confirmed by ELISA testing). In summary, using different techniques, we showed that human dermal TCs and Fbs are different in terms of ultrastructure and cytokine profile. ..
  15. Xu Y, Gao Y, Wu D, Yu F, Zang Z, Yang L, et al. Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells. Proteomics Clin Appl. 2017;11: pubmed publisher
    ..The imbalance of Zn homeostasis and elevation of angiogenic and epithelial-mesenchymal transition-promoting cytokines in Cd-adapted cells might thus likely promote Zn deficiency, angiogenesis, and cell invasion. ..
  16. Yan H, Jiang J, Pang Y, Achyut B, Lizardo M, Liang X, et al. CCL9 Induced by TGFβ Signaling in Myeloid Cells Enhances Tumor Cell Survival in the Premetastatic Organ. Cancer Res. 2015;75:5283-98 pubmed publisher
    ..The expression level of CCL23, the human orthologue for CCL9, in peripheral blood mononuclear cells correlated with progression and survival of ..
  17. Mayado A, Teodosio C, Garcia Montero A, Matito A, Rodriguez Caballero A, Morgado J, et al. Increased IL6 plasma levels in indolent systemic mastocytosis patients are associated with high risk of disease progression. Leukemia. 2016;30:124-30 pubmed publisher
    ..However, no study has simultaneously investigated the plasma levels of IL1β, IL6, IL13, CCL23 and clusterin in SM at diagnosis and correlated them with disease outcome...
  18. Parkar A, Adriaensen M, Fischer Bredenbeck C, Inderhaug E, Strand T, Assmus J, et al. Measurements of tunnel placements after anterior cruciate ligament reconstruction--A comparison between CT, radiographs and MRI. Knee. 2015;22:574-9 pubmed publisher
    ..Effective radiation dose from CT was lower than previously reported. CT can safely be used in routine clinical practice to evaluate tunnel placements after ACL reconstruction. ..
  19. Marlicz W, Wunsch E, Mydlowska M, Milkiewicz M, Serwin K, Mularczyk M, et al. The effect of short term treatment with probiotic VSL#3 on various clinical and biochemical parameters in patients with liver cirrhosis. J Physiol Pharmacol. 2016;67:867-877 pubmed
    ..6 (IL-6), vascular endothelial growth factor (VEGF), plasminogen activator inhibitor (PAI), macrophage inflammatory protein 3/? (MIP-3 ?/CCL20), monocyte chemotactic protein-1? (MCP-1/CCL2), human myeloperoxidase (MPO), nitric ..
  20. Tang M, Ou N, Li C, Lu A, Li J, Ma L, et al. Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma. Biomed Res Int. 2015;2015:617143 pubmed publisher
    ..036). Both MIP-3α and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients. MIP-3α and cystatin A expressions may be valuable prognostic markers in NPC patients. ..
  21. Gong F, Wu J, Zhou P, Zhang M, Liu J, Liu Y, et al. Interleukin-22 Might Act as a Double-Edged Sword in Type 2 Diabetes and Coronary Artery Disease. Mediators Inflamm. 2016;2016:8254797 pubmed
    ..Our results suggest that IL-22 functions as a double-edged sword in T2DM and CAD and that IL-22 may be used in the treatment of chronic inflammatory diseases such as T2DM and CAD. ..
  22. Blanchard C, Stucke E, Rodriguez Jimenez B, Burwinkel K, Collins M, Ahrens A, et al. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011;127:208-17, 217.e1-7 pubmed publisher
    ..Esophageal transcripts of numerous chemokines (eg, chemokine [C-C motif] ligand [CCL] 1, CCL1, CCL23, CCL26 [eotaxin-3], chemokine [C-X-C motif] ligand [CXCL] 1, and CXCL2), cytokines (eg, IL13 and ATP-binding ..
  23. Aziz N, Detels R, Chang L, Butch A. Macrophage Inflammatory Protein-3 Alpha (MIP-3α)/CCL20 in HIV-1-Infected Individuals. J AIDS Clin Res. 2016;7: pubmed
    ..Involvement of CCR6/CCL20 axis and epithelial cells at the recto-colonel level may enhance sexual transmission of HIV-1 in MSM and may be useful as a prognostic marker in HIV-1-infection and AIDS. ..
  24. Bayramoglu G, Arica M, Liman G, Celikbicak O, Salih B. Removal of bisphenol A from aqueous medium using molecularly surface imprinted microbeads. Chemosphere. 2016;150:275-284 pubmed publisher
    ..Finally, the binary and multi-component systems results show that MIP-3 microbeads have special recognition selectivity and excellent binding affinity for template molecule "BPA". ..
  25. Singh U, Singh N, Murphy E, Price R, Fayad R, Nagarkatti M, et al. Chemokine and cytokine levels in inflammatory bowel disease patients. Cytokine. 2016;77:44-9 pubmed publisher
    ..We found a significant increase in an array of chemokines including macrophage migration factor (MIF), CCL25, CCL23, CXCL5, CXCL13, CXCL10, CXCL11, MCP1, and CCL21 in IBD patients as compared to normal healthy donors (P<0.05)...
  26. Poposki J, Keswani A, Kim J, Klingler A, Suh L, Norton J, et al. Tissue proteases convert CCL23 into potent monocyte chemoattractants in patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2016;137:1274-1277.e9 pubmed publisher
  27. Hwang J, Son K, Kim C, Ko J, Na D, Kwon B, et al. Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis. Cytokine. 2005;30:254-63 pubmed
    ..We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKbeta8) to promote angiogenesis, which induces chemotaxis of immune cells ..
  28. Matsumoto K, Fukuda S, Hashimoto N, Saito H. Human eosinophils produce and release a novel chemokine, CCL23, in vitro. Int Arch Allergy Immunol. 2011;155 Suppl 1:34-9 pubmed publisher
    b>CCL23 (MPIF1/CK-BETA-8) is a novel CC chemokine that plays important roles in the inhibition of myeloid progenitor cell development, the selective recruitment of resting T lymphocytes and monocytes, and the potentiation of VEGF-induced ..
  29. Lim W, Bae H, Bazer F, Song G. C-C motif chemokine ligand 23 abolishes ER stress- and LPS-induced reduction in proliferation of bovine endometrial epithelial cells. J Cell Physiol. 2017;: pubmed publisher
    ..In this study, we investigated the effects of C-C-motif chemokine ligand 23 (CCL23) on the proliferation of bovine endometrial (BEND) epithelial cells...
  30. Lu X, Lu J, Liao B, Li X, Qian X, Li K. Driver pattern identification over the gene co-expression of drug response in ovarian cancer by integrating high throughput genomics data. Sci Rep. 2017;7:16188 pubmed publisher
    ..identified candidate modulators are known to be involved in biological meaningful processes associated with ovarian cancer, such as CCL11, CCL16, CCL18, CCL23, CCL8, CCL5, APOB, BRCA1, SLC18A1, FGF22, GADD45B, GNA15, GNA11, and so on.
  31. Yu L, Cao Z, Makhoul I, Daniels J, Klimberg S, Wei J, et al. Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients. Exp Biol Med (Maywood). 2017;:1535370217746383 pubmed publisher
    ..the patients with abnormal decline of LVEF (>10%) had lower levels of CXCL6 and sICAM-1 and higher levels of CCL23 and CCL27 at T0; higher levels of CCL23 and lower levels of CXCL5, CCL26, CXCL6, GM-CSF, CXCL1, IFN-?, IL-2, IL-8, ..
  32. Nomiyama H, Fukuda S, Iio M, Tanase S, Miura R, Yoshie O. Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, HCC-1, LEC, and RANTES. J Interferon Cytokine Res. 1999;19:227-34 pubmed
    ..2, we determined the nucleotide sequence of a region 181 kb long containing five CC chemokine genes, MPIF-1 (SCYA23), HCC-2 (SCYA15), HCC-1 (SCYA14), LEC (SCYA16), and RANTES (SCYA5), by the random shot-gun method...
  33. He S, Tan W, Wang S, Wu C, Wang P, Wang B, et al. Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. Chin Med J (Engl). 2014;127:72-8 pubmed
    ..with spontaneous autoimmunity; BMP5 and BMP7, involved in cardiomyocyte differentiation defect; and ADAMTS 8, CCL23, and TNFSF15, implicated in anti-angiogenic activities...
  34. Ye R, Cavanagh S, Quehenberger O, Prossnitz E, Cochrane C. Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem Biophys Res Commun. 1992;184:582-9 pubmed
    ..These findings suggest that FPR2 is a novel receptor for formyl peptide ligand and a new member of the chemoattractant receptor gene family. ..
  35. Pawlak K, Myśliwiec M, Pawlak D. Effect of diabetes and oxidative stress on plasma CCL23 levels in patients with severe chronic kidney disease. Pol Arch Med Wewn. 2014;124:459-66 pubmed
    b>CCL23 is a new CC chemokine involved in leukocyte trafficking and inflammatory diseases...
  36. Jeong W, Bae H, Lim W, Bazer F, Song G. Differential expression and functional roles of chemokine (C-C motif) ligand 23 and its receptor chemokine (C-C motif) receptor type 1 in the uterine endometrium during early pregnancy in pigs. Dev Comp Immunol. 2017;76:316-325 pubmed publisher
    ..However, little is known about expression and functional roles of chemokine (C-C motif) ligand 23 (CCL23) in the uterine endometrium...
  37. Zlotnik A, Yoshie O. The chemokine superfamily revisited. Immunity. 2012;36:705-16 pubmed publisher
    ..Here, we update the full scope of the human and mouse chemokine superfamilies and their relationships and summarize several important roles that homeostatic chemokines play in the immune system. ..
  38. Bäckryd E, Lind A, Thulin M, Larsson A, Gerdle B, Gordh T. High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain: a cross-sectional study of 2 cohorts of patients compared with healthy controls. Pain. 2017;158:2487-2495 pubmed publisher
    ..Levels of chemokines CXCL6, CXCL10, CCL8, CCL11, CCL23 in CSF, as well as protein LAPTGF-beta-1, were significantly higher in both neuropathic pain cohorts compared with ..
  39. Qi W, Holian J, Tan C, Kelly D, Chen X, Pollock C. The roles of Kruppel-like factor 6 and peroxisome proliferator-activated receptor-? in the regulation of macrophage inflammatory protein-3? at early onset of diabetes. Int J Biochem Cell Biol. 2011;43:383-92 pubmed publisher
    ..Targeting pro-inflammatory chemokine MIP-3? and its signaling pathways will provide novel strategy to treat diabetic kidney disease. ..
  40. Kim J, Kim Y, Ko J. CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF-kappa B and is involved in inflammatory responses. Life Sci. 2010;86:300-8 pubmed publisher
    CKbeta8/CCL23 is a CC chemokine and alternative splicing of the CKbeta8 gene produces two mRNAs that encode CKbeta8 and its isoform CKbeta8-1...
  41. Rioja I, Hughes F, Sharp C, Warnock L, Montgomery D, Akil M, et al. Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor. Arthritis Rheum. 2008;58:2257-67 pubmed publisher
    ..markers macrophage colony-stimulating factor (M-CSF), tumor necrosis factor receptor superfamily member 9, CCL23, transforming growth factor alpha, and CXCL13...
  42. Novak H, Müller A, Harrer N, Günther C, Carballido J, Woisetschläger M. CCL23 expression is induced by IL-4 in a STAT6-dependent fashion. J Immunol. 2007;178:4335-41 pubmed
    The chemokine CCL23 is primarily expressed in cells of the myeloid lineage but little information about its regulation is available...
  43. Gervais R, Fitzsimmons G, Thomas N. Masseter and temporalis electromyographic activity in asymptomatic, subclinical, and temporomandibular joint dysfunction patients. Cranio. 1989;7:52-7 pubmed
    ..These findings strengthen diagnostic and assessment procedures and criteria, as well as suggest alternate treatment and research protocols. ..
  44. Susilowati H, Murakami K, Yumoto H, Amoh T, Hirao K, Hirota K, et al. Royal Jelly Inhibits Pseudomonas aeruginosa Adherence and Reduces Excessive Inflammatory Responses in Human Epithelial Cells. Biomed Res Int. 2017;2017:3191752 pubmed publisher
    ..aeruginosa infection. Our findings suggested that royal jelly may be a useful supplement as complementary and alternative medicine for preventing respiratory infection caused by P. aeruginosa. ..
  45. Youn B, Zhang S, Broxmeyer H, Cooper S, Antol K, Fraser M, et al. Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1. Blood. 1998;91:3118-26 pubmed
    ..To our knowledge, this is the first example that an alternative splicing produces two active beta-chemokines from a single gene. ..
  46. Wells T, Peitsch M. The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases. J Leukoc Biol. 1997;61:545-50 pubmed
  47. Patel V, Kreider B, Li Y, Li H, Leung K, Salcedo T, et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J Exp Med. 1997;185:1163-72 pubmed
    Two novel human beta-chemokines, Ck beta-8 or myeloid progenitor inhibitory factor 1 (MPIF-1), and Ck beta-6 or MPIF-2, were discovered as part of a large scale cDNA sequencing effort...
  48. Naruse K, Ueno M, Satoh T, Nomiyama H, Tei H, Takeda M, et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996;34:236-40 pubmed
    ..2, LD78beta)-(NCC-3, NCC-2, AT744.1, LD78alpha)-NCC-4-retinoic acid receptor alpha- telomere. ..
  49. Starr A, Dufour A, Maier J, Overall C. Biochemical analysis of matrix metalloproteinase activation of chemokines CCL15 and CCL23 and increased glycosaminoglycan binding of CCL16. J Biol Chem. 2012;287:5848-60 pubmed publisher
    ..Recent evidence has shown activating cleavages of the monocyte chemoattractants CCL15 and CCL23 by incubation with synovial fluid, although the responsible proteases could not be identified...
  50. Kim C, Kang J, Cho H, Blankenship T, Erickson K, Kawada T, et al. Potential involvement of CCL23 in atherosclerotic lesion formation/progression by the enhancement of chemotaxis, adhesion molecule expression, and MMP-2 release from monocytes. Inflamm Res. 2011;60:889-95 pubmed publisher
    CCL23 [Ck?8-1/myeloid progenitor inhibitory factor 1 (MPIF1)/macrophage inflammatory protein-3 (MIP3)], a member of the CC chemokine family, is involved in leukocyte trafficking, and implicated in inflammatory diseases...
  51. Poposki J, Uzzaman A, Nagarkar D, Chustz R, Peters A, Suh L, et al. Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2011;128:73-81.e4 pubmed publisher
    ..The objective of this study was to investigate the expression of the chemokine CCL23, which is known to bind to CCR1 and recruit monocytes, macrophages, and dendritic cells, in patients with CRS...
  52. Castillo L, Rohatgi A, Ayers C, Owens A, Das S, Khera A, et al. Associations of four circulating chemokines with multiple atherosclerosis phenotypes in a large population-based sample: results from the dallas heart study. J Interferon Cytokine Res. 2010;30:339-47 pubmed publisher
    ..CXCL1 and CCL11 have previously been studied in animal or human models of atherosclerosis, while CXCL2 and CCL23 have not...
  53. Kim J, Kim Y, Ko J. CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-cycle progression. Cytokine. 2010;50:42-9 pubmed publisher
    CKbeta8/CCL23 is a CC chemokine and alternative splicing of the CKbeta8 gene produces two mRNAs that encode CKbeta8 and its isoform CKbeta8-1...
  54. Han K, Kim C, Lee T, Son Y, Kim J. CCL23 up-regulates expression of KDR/Flk-1 and potentiates VEGF-induced proliferation and migration of human endothelial cells. Biochem Biophys Res Commun. 2009;382:124-8 pubmed publisher
    b>CCL23 is a CC chemokine and exerts its biological activities on endothelial cells as well as on immune cells through CCR1. We investigated the potential effect of CCL23 on expression of KDR/Flk-1 receptor in endothelial cells...
  55. Son K, Hwang J, Kwon B, Kim J. Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells. Biochem Biophys Res Commun. 2006;340:498-504 pubmed
    Human CCL23 (also known as CKbeta8, MPIF-1, or MIP-3) has been recently reported to induce endothelial cell migration and tube formation via CCR1...
  56. Berkhout T, Gohil J, Gonzalez P, Nicols C, Moores K, Macphee C, et al. Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1). Biochem Pharmacol. 2000;59:591-6 pubmed
    ..The longer variants of CKbeta8 are significantly less potent than CKbeta8 (25-99) and MIP-1a on CCR1 and monocytes (P < 0.05). ..
  57. Luo K, Zavala F, Gordy J, Zhang H, Markham R. Extended protection capabilities of an immature dendritic-cell targeting malaria sporozoite vaccine. Vaccine. 2017;35:2358-2364 pubmed publisher
    ..is used in combination with a vaccine in which the immature dendritic cell targeting chemokine, macrophage inflammatory protein 3 alpha (MIP3?), is fused to the circumsporozoite protein (CSP) of Plasmodium falciparum (P...
  58. Votta B, White J, Dodds R, James I, Connor J, Lee Rykaczewski E, et al. CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues. J Cell Physiol. 2000;183:196-207 pubmed
    ..These observations suggest that CKbeta-8, and perhaps other chemokines, may play a role in the recruitment of osteoclast precursors to sites of bone resorption. ..
  59. Rajarathnam K, Li Y, Rohrer T, Gentz R. Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine. J Biol Chem. 2001;276:4909-16 pubmed
    ..The MPIF-1 structure should serve as a template for future functional studies that could lead to therapeutics for preventing chemotherapy-associated myelotoxicity. ..
  60. Maho A, Carter A, Bensimon A, Vassart G, Parmentier M. Physical mapping of the CC-chemokine gene cluster on the human 17q11. 2 region. Genomics. 1999;59:213-23 pubmed
    ..This map of the CC-chemokine gene cluster should facilitate the determination of the full sequence of the chromosomal region. ..
  61. Kim K, Lee J, Yang Y, You K, Lee J. Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. Carcinogenesis. 2008;29:704-12 pubmed publisher
    ..Collectively, these results show that MIC-1 may participate in the malignant progression of certain human cancer cells that overexpress ErbB2 through the transactivation of ErbB2 tyrosine kinase. ..
  62. Yanaba K, Yoshizaki A, Muroi E, Ogawa F, Asano Y, Kadono T, et al. Serum CCL23 levels are increased in patients with systemic sclerosis. Arch Dermatol Res. 2011;303:29-34 pubmed publisher
    The aim of this study is to determine serum CCL23 levels and their clinical associations in patients with systemic sclerosis (SSc)...
  63. Yao T, Du G, Han L, Sun Y, Hu D, Yang J, et al. Genome-wide association study of lung function phenotypes in a founder population. J Allergy Clin Immunol. 2014;133:248-55.e1-10 pubmed publisher
    ..Lung function is a long-term predictor of mortality and morbidity...
  64. Szczeklik W, Jakieła B, Wawrzycka Adamczyk K, Sanak M, Hubalewska Mazgaj M, Padjas A, et al. Skewing toward Treg and Th2 responses is a characteristic feature of sustained remission in ANCA-positive granulomatosis with polyangiitis. Eur J Immunol. 2017;47:724-733 pubmed publisher
    ..Finally, analyzing the cytokine profile, we identified CCL23 and LIGHT, as potential biomarkers of active disease...
  65. Nardelli B, Tiffany H, Bong G, Yourey P, Morahan D, Li Y, et al. Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1. J Immunol. 1999;162:435-44 pubmed
    ..Thus, the MPIF-1 signal transduction pathway appears to include binding to CCR1; transduction by G proteins; effector function by phospholipase C, protein kinase C, calcium flux, and PLA2; and cytoskeletal remodeling. ..
  66. Li S, Tu W, Zhong Y, Jiang X, Jiang S. [Involvement of Central Neuroglia Cells in Analgesic Effect of Electroacupuncture Therapy for Neuropathic Pain]. Zhen Ci Yan Jiu. 2016;41:369-372 pubmed
    ..The effects of some related protein and gene expressions involving in acupuncture analgesia need being confirmed by adopting different approaches. ..