Gene Symbol: CCL21
Description: C-C motif chemokine ligand 21
Alias: 6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, C-C motif chemokine 21, Efficient Chemoattractant for Lymphocytes, beta chemokine exodus-2, chemokine (C-C motif) ligand 21, secondary lymphoid tissue chemokine, small inducible cytokine subfamily A (Cys-Cys), member 21
Species: human
Products:     CCL21

Top Publications

  1. Takeuchi H, Fujimoto A, Tanaka M, Yamano T, Hsueh E, Hoon D. CCL21 chemokine regulates chemokine receptor CCR7 bearing malignant melanoma cells. Clin Cancer Res. 2004;10:2351-8 pubmed
    The chemokine CC-ligand 21/secondary lymphoid tissue chemokine (CCL21/SLC) regulates the homing of naïve T cells and dendritic cells that express CC-chemokine receptor 7 (CCR7) from distant sites to lymphoid tissue such as lymph nodes...
  2. Pierce E, Carpenter K, Jakubzick C, Kunkel S, Evanoff H, Flaherty K, et al. Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21. Eur Respir J. 2007;29:1082-93 pubmed
    ..fibroblasts, but not normal fibroblasts, showed significant migratory and proliferative responses when exposed to CCL21, which were inhibited by pertussis toxin or neutralising antibodies to CCR7...
  3. Sanchez Sanchez N, Riol Blanco L, de la Rosa G, Puig Kröger A, García Bordas J, Martin D, et al. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood. 2004;104:619-25 pubmed
    ..Stimulation with CCR7 ligands CCL19 and CCL21 inhibits apoptotic hallmarks of serum-deprived DCs, including membrane phosphatidylserine exposure, loss of ..
  4. Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O. Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. J Biol Chem. 1998;273:7118-22 pubmed
    Secondary Lymphoid-tissue Chemokine (SLC) is a recently identified CC chemokine that is constitutively expressed in various lymphoid tissues and is a potent and specific chemoattractant for lymphocytes...
  5. Shannon L, Calloway P, Welch T, Vines C. CCR7/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1/2 in primary T lymphocytes. J Biol Chem. 2010;285:38781-7 pubmed publisher
    CCR7 binds to its cognate ligand, CCL21, to mediate the migration of circulating naive T lymphocytes to the lymph nodes...
  6. Pickens S, Chamberlain N, Volin M, Pope R, Talarico N, Mandelin A, et al. Role of the CCL21 and CCR7 pathways in rheumatoid arthritis angiogenesis. Arthritis Rheum. 2012;64:2471-81 pubmed publisher
    To determine the role of CCL21 and its receptor CCR7 in the pathogenesis of rheumatoid arthritis (RA). Histologic studies were performed to compare the expression of CCR7 and CCL21 in RA synovial tissue...
  7. Weninger W, Carlsen H, Goodarzi M, Moazed F, Crowley M, Baekkevold E, et al. Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis. J Immunol. 2003;170:4638-48 pubmed
    ..GFP(+) cells underwent selectin-dependent rolling, but no firm adherence (sticking). Superfusion with CCL21, but not CXC chemokine ligand 12, induced integrin-dependent sticking of GFP(+) cells...
  8. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan M, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410:50-6 pubmed
    ..Their respective ligands CXCL12/SDF-1alpha and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis...
  9. Xu Y, Liu L, Qiu X, Jiang L, Huang B, Li H, et al. CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells. PLoS ONE. 2011;6:e21119 pubmed publisher
    ..using Cell Counting Kit-8 indicated that activation of CCR7 by its specific ligand, exogenous chemokine ligand 21 (CCL21), was associated with a significant linear increase in cell proliferation with duration of exposure to CCL21...

More Information


  1. Riol Blanco L, Sanchez Sanchez N, Torres A, Tejedor A, Narumiya S, Corbi A, et al. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol. 2005;174:4070-80 pubmed
    ..The use of independent signaling modules to control chemotaxis and speed can contribute to regulate the chemotactic effects of CCR7. ..
  2. Yndestad A, Finsen A, Ueland T, Husberg C, Dahl C, Øie E, et al. The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure. PLoS ONE. 2012;7:e33038 pubmed publisher
    CCL19 and CCL21, acting through CCR7, are termed homeostatic chemokines...
  3. Carlsen H, Haraldsen G, Brandtzaeg P, Baekkevold E. Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules. Blood. 2005;106:444-6 pubmed
    ..The CCR7 ligand designated CCL21 is considered the most important trigger because it appears constitutively expressed by murine HEVs...
  4. Hirose J, Kawashima H, Yoshie O, Tashiro K, Miyasaka M. Versican interacts with chemokines and modulates cellular responses. J Biol Chem. 2001;276:5228-34 pubmed
    ..We next examined if versican or GAGs affect secondary lymphoid tissue chemokine (SLC)-induced integrin activation and Ca(2+) mobilization in lymphoid cells expressing a receptor ..
  5. Jenh C, Cox M, Kaminski H, Zhang M, Byrnes H, Fine J, et al. Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors. J Immunol. 1999;162:3765-9 pubmed
    The CC chemokine known as 6Ckine (SLC, Exodus-2, or TCA4) has been identified as a ligand for CCR7...
  6. Campbell J, Bowman E, Murphy K, Youngman K, Siani M, Thompson D, et al. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7. J Cell Biol. 1998;141:1053-9 pubmed
    The beta chemokine known as 6-C-kine, secondary lymphoid-tissue chemokine (SLC), TCA4, or Exodus-2 (herein referred to as 6CK/SLC) can trigger rapid integrin-dependent arrest of lymphocytes rolling under physiological shear and is highly ..
  7. Gunn M, Tangemann K, Tam C, Cyster J, Rosen S, Williams L. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci U S A. 1998;95:258-63 pubmed
    ..Here we show that a chemokine represented in the EST database, secondary lymphoid-tissue chemokine (SLC), is expressed in the high endothelial venules of lymph nodes and Peyer's patches, in the T cell areas of spleen, ..
  8. Banas B, Wornle M, Merkle M, Gonzalez Rubio M, Schmid H, Kretzler M, et al. Binding of the chemokine SLC/CCL21 to its receptor CCR7 increases adhesive properties of human mesangial cells. Kidney Int. 2004;66:2256-63 pubmed
    ..A constitutive expression of the chemokine SLC/CCL21 on human podocytes and of its corresponding receptor CCR7 on mesangial cells was shown before...
  9. Scandella E, Men Y, Legler D, Gillessen S, Prikler L, Ludewig B, et al. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood. 2004;103:1595-601 pubmed
    ..Activated DCs home to lymphoid organs, where the CCR7 ligands CCL19 and CCL21 are expressed...
  10. Manzo A, Bugatti S, Caporali R, Prevo R, Jackson D, Uguccioni M, et al. CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis. Am J Pathol. 2007;171:1549-62 pubmed
    b>CCL21 is a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cells and dendritic cells into lymphoid T areas...
  11. Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpaa M, Takagi S, et al. Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13. J Biol Chem. 1997;272:19518-24 pubmed
    ..hybrids, radiation hybrids, and selected yeast and bacterial artificial chromosome clones, we mapped the SLC gene (SCYA21) at chromosome 9p13 and between chromosomal markers, D9S1978(WI-8765) and AFM326vd1, where the gene for another ..
  12. Hedrick J, Zlotnik A. Identification and characterization of a novel beta chemokine containing six conserved cysteines. J Immunol. 1997;159:1589-93 pubmed
    ..of a novel beta (CC) chemokine that exhibits an unusual pattern of six conserved cysteines and was thus designated 6Ckine. The primary amino acid sequence of 6Ckine is highly conserved in humans, mice, and pigs and contains the expected ..
  13. Paoletti S, Petkovic V, Sebastiani S, Danelon M, Uguccioni M, Gerber B. A rich chemokine environment strongly enhances leukocyte migration and activities. Blood. 2005;105:3405-12 pubmed
    ..Chemokine-induced synergism might provide an amplification system in "chemokine-rich" tissues, rendering leukocytes more competent to respond to migratory cues. ..
  14. Ott T, Lio F, Olshefski D, Liu X, Ling N, Struthers R. The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19. Biochem Biophys Res Commun. 2006;348:1089-93 pubmed
    ..the trafficking of leucocytes to the secondary lymphoid organs, has two endogenous chemokine ligands: CCL19 and CCL21. Although both ligands possess similar affinities for the receptor and similar abilities to promote G protein ..
  15. Hromas R, Kim C, Klemsz M, Krathwohl M, Fife K, Cooper S, et al. Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J Immunol. 1997;159:2554-8 pubmed
    ..The combination of these characteristics may be a functional correlate for the unique carboxyl-terminal structure of Exodus-2. ..
  16. Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron P, Lewin S. CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency. Blood. 2007;110:4161-4 pubmed
    ..resting CD4(+) T cells, we infected purified resting CD4(+) T cells after incubation with the chemokines CCL19 and CCL21. Incubation with CCL19 or CCL21 did not alter markers of T-cell activation or proliferation...
  17. Raychaudhuri S, Remmers E, Lee A, Hackett R, Guiducci C, Burtt N, et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet. 2008;40:1216-23 pubmed publisher
    ..We also identified association at the CCL21 gene locus (rs2812378, P = 0.00097 replication, P = 2...
  18. Batistel F, Alharthi A, Wang L, Parys C, Pan Y, Cardoso F, et al. Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight. J Nutr. 2017;147:1640-1647 pubmed publisher
    ..As a result, mRNA expression of genes involved in neutral amino acid transport [solute carrier (SLC) family members SLC3A2, SLC7A5, SLC38A1, and SLC38A10], glucose transport [SLC2A1..
  19. Hadsell D, Hadsell L, Rijnkels M, Carcamo Bahena Y, Wei J, Williamson P, et al. In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1. Mamm Genome. 2018;: pubmed publisher
    ..This locus also contained the genes for solute carrier family (Slc) members Slc9a2, Slc9a4, Slc39a10, and Slc40a1...
  20. Athippozhy A, Huang L, Wooton Kee C, Zhao T, Jungsuwadee P, Stromberg A, et al. Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. BMC Genomics. 2011;12:95 pubmed publisher
    ..Several members of the Solute Carrier (SLC) and Adenosine Triphosphate Binding Cassette (ABC) superfamilies of membrane transporters were found to be ..
  21. Cai Y, Wu F, Hu W, Chen J, Chen S, Xu B, et al. Molecular characterization of Babesia microti seroreactive antigen 5-1-1 and development of rapid detection methods for anti-B. microti antibodies in serum. Acta Trop. 2018;185:371-379 pubmed publisher
    ..Enhanced chemiluminescence (ECL)-Western blot methods were used to detect specific antibodies in infected mice...
  22. Yemitan O, Adeyemi O. Mechanistic assessment of the analgesic, anti-inflammatory and antipyretic actions of Dalbergia saxatilis in animal models. Pharm Biol. 2017;55:898-905 pubmed publisher
    ..and dextran rat paw oedema tests; antipyretic activity was measured by Escherichia coli lipopolysaccharide (ECL) and turpentine in rabbits, and d-amphetamine sulphate (d-AS) pyrexia test in rats...
  23. Yamashita M, Mouri T, Niisato M, Nitanai H, Kobayashi H, Ogasawara M, et al. Lymphangiogenic factors are associated with the severity of hypersensitivity pneumonitis. BMJ Open Respir Res. 2015;2:e000085 pubmed publisher
    ..Levels of vascular endothelial growth factors (VEGF)-A, VEGF-C, VEGF-D and CCL21 in the serum and bronchoalveolar lavage fluid (BALF) were measured in 29 healthy volunteers, 14 patients with ..
  24. Xia Y, Si J, Li Z. Fabrication techniques for microfluidic paper-based analytical devices and their applications for biological testing: A review. Biosens Bioelectron. 2016;77:774-89 pubmed publisher
    ..electrochemical detection, fluorescence detection, chemiluminescence (CL) detection, electrochemiluninescence (ECL) detection, photoelectrochemi (PEC) detection and so on...
  25. Jiang Y, Bai J, Tang L, Zhang P, Pu J. Anti-CCL21 antibody attenuates infarct size and improves cardiac remodeling after myocardial infarction. Cell Physiol Biochem. 2015;37:979-90 pubmed publisher
    ..The CC-chemokine CCL21 is, via its receptor CCR7, one of the key regulators of inflammation and immune cell recruitment, participates in ..
  26. Perland E, Hellsten S, Lekholm E, Eriksson M, Arapi V, Fredriksson R. The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake. J Mol Neurosci. 2017;61:199-214 pubmed publisher
    ..The SLC family comprise about 400 transporters, and we have identified two new putative family members, major facilitator ..
  27. Barone F, Bombardieri M, Rosado M, Morgan P, Challacombe S, De Vita S, et al. CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. J Immunol. 2008;180:5130-40 pubmed
    The chemokines (CKs) CXCL13, CCL21, and CXCL12 are known to play differential roles in the organization of the lymphoid tissues and the development of lymphoid malignancies...
  28. Xiao Y, Xu L, Li P, Tang X, Qi L. A simple microdroplet chip consisting of silica nanochannel-assisted electrode and paper cover for highly sensitive electrochemiluminescent detection of drugs in human serum. Anal Chim Acta. 2017;983:96-102 pubmed publisher
    ..charged tris(2,2'-bipyridyl) ruthenium (II), resulting in a remarkably enhanced electrochemiluminescence (ECL) signal...
  29. Medina A, Banaszczak M, Ni Y, Aretz I, Meierhofer D. ?? Cells Feature De-Ubiquitination of SLC Transporters and Increased Levels and Fluxes of Amino Acids. Int J Mol Sci. 2017;18: pubmed publisher
    Solute carrier (SLC) transporters are a diverse group of membrane transporter proteins that regulate the cellular flux and distribution of endogenous and xenobiotic compounds...
  30. Jalali R, Zandieh Doulabi B, DenBesten P, Seidler U, Riederer B, Wedenoja S, et al. Slc26a3/Dra and Slc26a6 in Murine Ameloblasts. J Dent Res. 2015;94:1732-9 pubmed publisher
    ..Solute carrier (Slc) family 26A encodes different anion exchangers that exchange Cl(-)/HCO3 (-), including Slc26a3/Dra, Slc26a6/Pat-1, ..
  31. Chen X, Yin J, Zhang C, Lu N, Chen Z. Determination of Brilliant Blue FCF by a Novel Solid-state ECL Quenching Sensor of Ru(bpy)32+-poly(sulfosalicylic acid)/GCE. Anal Sci. 2017;33:1123-1128 pubmed publisher
    A novel solid-state electrochemiluminescence (ECL) quenching sensor was constructed for determination of brilliant blue FCF (BB FCF)...
  32. Zhu Q, Cai F, Zhang J, Zhao K, Deng A, Li J. Highly sensitive electrochemiluminescent immunosensor based on gold nanoparticles-functionalized zinc oxide nanorod and poly(amidoamine)-graphene for detecting brombuterol. Biosens Bioelectron. 2016;86:899-906 pubmed publisher
    ..A novel ultrasensitive competition-type electrochemiluminescent (ECL) immunosensor was developed for detecting brombuterol (Brom) based on CdTe Quantum dot (QDs) and polyamidoamine ..
  33. Shao Z, Gaurav R, Agrawal D. Intermediate-conductance calcium-activated potassium channel KCa3.1 and chloride channel modulate chemokine ligand (CCL19/CCL21)-induced migration of dendritic cells. Transl Res. 2015;166:89-102 pubmed publisher
    ..The amplitude and kinetics of chemokine ligand (CCL19/CCL21)-induced Ca(2+) influx were associated with chemokine receptor 7 expression levels, extracellular-free Ca(2+) and ..
  34. Jiang G, Liu X, Wang Y, Ruan S, Qi H, Yang Y, et al. Design and Application of Multi-functional Electrogenerated Chemiluminescence Imaging Analyzer. Anal Sci. 2016;32:1023-7 pubmed publisher
    A multi-functional eletrogenerated chemiluminescence (ECL) imaging analyzer including both a photomultiplier tube and charged coupled device as detectors has been developed...
  35. Boyce M, van den Berg F, Mitchell T, Darwin K, Warrington S. Randomised trial of the effect of a gastrin/CCK2 receptor antagonist on esomeprazole-induced hypergastrinaemia: evidence against rebound hyperacidity. Eur J Clin Pharmacol. 2017;73:129-139 pubmed publisher
    Hypergastrinaemia induced by proton pump inhibitor (PPI) therapy may cause ECL-cell and parietal-cell hyperplasia and rebound hyperacidity and dyspepsia after PPI withdrawal...
  36. Niu H, Klem T, Yang J, Qiu Y, Pan L. A biotin-drug extraction and acid dissociation (BEAD) procedure to eliminate matrix and drug interference in a protein complex anti-drug antibody (ADA) isotype specific assay. J Immunol Methods. 2017;446:30-36 pubmed publisher
    ..developed a biotin-drug extraction with acid dissociation (BEAD) procedure followed by an electrochemiluminescence (ECL) direct assay to overcome matrix and drug interference...
  37. Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, et al. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Res. 2017;27:352-372 pubmed publisher
    ..In response to oxLDL, macrophages show reduced migratory capacity toward chemokines CCL19 and CCL21; this capacity can be restored by blocking CD146...
  38. Singh U, Singh N, Murphy E, Price R, Fayad R, Nagarkatti M, et al. Chemokine and cytokine levels in inflammatory bowel disease patients. Cytokine. 2016;77:44-9 pubmed publisher
    ..of chemokines including macrophage migration factor (MIF), CCL25, CCL23, CXCL5, CXCL13, CXCL10, CXCL11, MCP1, and CCL21 in IBD patients as compared to normal healthy donors (P<0.05)...
  39. Ke H, Zhang X, Guo W, Zhang A, Wang Z, Huang C, et al. A MWCNTs-Pt nanohybrids-based highly sensitive electrochemiluminescence sensor for flavonoids assay. Talanta. 2017;171:1-7 pubmed publisher
    Electrochemiluminescent (ECL) assay has gradually drawn increasing interest to be considered as one of the potential strategies to be applicable in a wide range of medicine target determination...
  40. Platt E, Durnin J, Kabat D. Short Communication: HIV-1 Variants That Use Mouse CCR5 Reveal Critical Interactions of gp120's V3 Crown with CCR5 Extracellular Loop 1. AIDS Res Hum Retroviruses. 2015;31:992-8 pubmed publisher
    The CCR5 coreceptor amino terminus and extracellular (ECL) loops 1 and 2 have been implicated in HIV-1 infections, with species differences in these regions inhibiting zoonoses...
  41. Elhaj Mahmoud D, Sassi N, Drissi G, Barsaoui M, Zitouna K, Sahli H, et al. sFRP3 and DKK1 Regulate Fibroblast-Like Synoviocytes Markers and Wnt Elements Expression Depending on Cellular Context. Immunol Invest. 2017;46:314-328 pubmed publisher
    ..bovine serum; PBS: phosphate buffered saline; SDS-PAGE: sodium dodecyl sulfate-polyacrylamide gel electrophoresis; ECL: enhanced chemiluminescence detection solution; MMP3: metaloproteinase 3; qRT-PCR: quantitative real-time ..
  42. Sundaresan S, Kang A, Hayes M, Choi E, Merchant J. Deletion of Men1 and somatostatin induces hypergastrinemia and gastric carcinoids. Gut. 2017;66:1012-1021 pubmed publisher
    Gastric carcinoids are slow growing neuroendocrine tumours arising from enterochromaffin-like (ECL) cells in the corpus of stomach...
  43. Dong Y, Zhou Y, Wang J, Dong Y, Wang C. Electrogenerated chemiluminescence of quantum dots with lucigenin as coreactant for sensitive detection of catechol. Talanta. 2016;146:266-71 pubmed publisher
    Electrogenerated chemiluminescence (ECL) of quantum dots (QDs), including CdS, CdSe, CdTe, and CdSe@ZnS QDs, was comparatively studied in neutral lucigenin solution without coreactants. Cathodic ECL signals were obtained at -1...
  44. Lee J, Cho K, Shin S, Bae H, Koo T, Han G, et al. Nutrient Recovery of Starch Processing Waste to Cordyceps militaris: Solid State Cultivation and Submerged Liquid Cultivation. Appl Biochem Biotechnol. 2016;180:274-88 pubmed publisher
    ..bioconversion to Cordyceps militaris mycelia using solid state cultivation (SSC) and submerged liquid cultivation (SLC). The growth characteristics of C...
  45. Fan Y, Tan X, Ou X, Chen S, Wei S. An ultrasensitive electrochemiluminescence biosensor for the detection of concanavalin A based on Au nanoparticles-thiosemicarbazide functionalized PtNi nanocubes as signal enhancer. Biosens Bioelectron. 2017;87:802-806 pubmed publisher
    A sandwich-configuration electrochemiluminescence (ECL) biosensor was constructed for detecting concanavalin A (ConA) based on peroxydisulfate/oxygen (S2O82-/O2) system...
  46. Wei Y, Wang H, Sun S, Tang L, Cao Y, Deng B. An ultrasensitive electrochemiluminescence sensor based on reduced graphene oxide-copper sulfide composite coupled with capillary electrophoresis for determination of amlodipine besylate in mice plasma. Biosens Bioelectron. 2016;86:714-719 pubmed publisher
    A new electrochemiluminescence (ECL) sensor based on reduced graphene oxide-copper sulfide (rGO-CuS) composite coupled with capillary electrophoresis (CE) was constructed for the ultrasensitive detection of amlodipine besylate (AML) for ..
  47. Haghighatbin M, Lo S, Burn P, Hogan C. Electrochemically tuneable multi-colour electrochemiluminescence using a single emitter. Chem Sci. 2016;7:6974-6980 pubmed publisher
    ..which red, green, blue or white emission can be obtained, depending on the applied potential or the mode of the ECL experiment, is described...
  48. Li Y, Li Y, Wu Y, Lu F, Chen Y, Gao W. An electrochemiluminescence biosensor for endonuclease EcoRI detection. Biosens Bioelectron. 2017;89:585-591 pubmed publisher
    ..This work was going to develop a reliable and sensitive electrochemiluminescent (ECL) biosensor for detecting endonucleases by using gold nanoparticles graphene composite (GNPs-graphene) as a signal ..
  49. Reinisch W, Jahnsen J, Schreiber S, Danese S, Panés J, Balsa A, et al. Evaluation of the Cross-reactivity of Antidrug Antibodies to CT-P13 and Infliximab Reference Product (Remicade): An Analysis Using Immunoassays Tagged with Both Agents. BioDrugs. 2017;31:223-237 pubmed publisher
    ..from patients with rheumatoid arthritis and ankylosing spondylitis were analysed using an electrochemiluminescence (ECL) bridging assay or Gyros immunoassay, tagged with Remicade or CT-P13 at screening, weeks 14, 30 and 54, and the end ..
  50. Katayama Y, Ohgi T, Mitoma Y, Hifumi E, Egashira N. Detection of influenza virus by a biosensor based on the method combining electrochemiluminescence on binary SAMs modified Au electrode with an immunoliposome encapsulating Ru (II) complex. Anal Bioanal Chem. 2016;408:5963-71 pubmed publisher
    ..We would like to report detection of influenza virus A (H1N1) by an immunosensor based on electrochemiluminescence (ECL) that uses an immunoliposome encapsulating tris(2,2'-bipyridyl)ruthenium(II) complex...
  51. Jiang X, Wang H, Wang H, Zhuo Y, Yuan R, Chai Y. Self-enhanced N-(aminobutyl)-N-(ethylisoluminol) derivative-based electrochemiluminescence immunosensor for sensitive laminin detection using PdIr cubes as a mimic peroxidase. Nanoscale. 2016;8:8017-23 pubmed publisher
    Herein, a self-enhanced N-(aminobutyl)-N-(ethylisoluminol) (ABEI) derivative-based electrochemiluminescence (ECL) immunosensor was constructed for the determination of laminin (LN) using PdIr cubes as a mimic peroxidase for signal ..
  52. Wei Y, Liu J, Zhang H, Du X, Luo Q, Sun J, et al. Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model. Environ Toxicol Pharmacol. 2016;46:55-61 pubmed publisher
    ..In addition, ligustrazine significantly reduces IL-4, IL-5, IL-17A, CCL3, CCL19 and CCL21 level in BALF of asthma mice...
  53. Sand L, Berghuis D, Szuhai K, Hogendoorn P. Expression of CCL21 in Ewing sarcoma shows an inverse correlation with metastases and is a candidate target for immunotherapy. Cancer Immunol Immunother. 2016;65:995-1002 pubmed publisher
    ..b>CCL21 activation-based immunotherapy was successful in preclinical studies in other tumor types; therefore, we ..
  54. Bryce S, Wilson R, Tiplady E, Asquith D, Bromley S, Luster A, et al. ACKR4 on Stromal Cells Scavenges CCL19 To Enable CCR7-Dependent Trafficking of APCs from Inflamed Skin to Lymph Nodes. J Immunol. 2016;196:3341-53 pubmed publisher
    ..CCR7 is activated by two chemokines: CCL19 and CCL21. CCL21 alone is sufficient for the migration of APCs from skin to LN...
  55. Gómez D, Diehl M, Crosby E, Weinkopff T, Debes G. Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation. J Immunol. 2015;195:3531-6 pubmed publisher
    ..Lymph-borne Th1 and Th17 cells draining the inflamed skin of sheep migrated toward the CCR7 ligand CCL21, suggesting the CCR7-CCL21 axis as a physiological target in regulating inflammation...
  56. Raju R, Gadakh S, Gopal P, George B, Advani J, Soman S, et al. Differential ligand-signaling network of CCL19/CCL21-CCR7 system. Database (Oxford). 2015;2015: pubmed publisher
    ..CCL19 and CCL21, the two well-characterized CCR7 ligands, have been established to be differential in their signaling through CCR7 ..
  57. Rong Y, Chen X, Fan D, Lin X, Zheng X, Zhou C, et al. [Influence of CCL21 on the invasion and metastasis of colorectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2017;20:1300-1305 pubmed
    To investigate the influence of CCL21 on the invasion and metastasis of colorectal cancer (CRC).
  58. Hong C, Lee H, Kim H, Lee J. The lymphoid chemokine CCL21 enhances the cytotoxic T lymphocyte-inducing functions of dendritic cells. Scand J Immunol. 2014;79:173-80 pubmed publisher
    ..mDCs exposed to a secondary lymphoid organ chemokine (SLC/CCL21) dramatically induced CTL response by increasing cytolytic activity without any significant alterations on ..
  59. Xiong Y, Liu L, Wang J, Xi W, Xia Y, Bai Q, et al. Low CCL-21 expression associates with unfavorable postoperative prognosis of patients with metastatic renal cell carcinoma. Oncotarget. 2017;8:25650-25659 pubmed publisher
    Chemokine (C-C motif) ligand 21 (CCL21), a ligand of the chemokine (C-C motif) receptor 7, has recently been identified as an immuno-based anti-cancer molecule for its dendritic cells and T lymphocytes chemoattractant function...
  60. Zhang H, Zhang X, Ding X, Cao W, Qu L, Zhou G. Effect of secondary lymphoid tissue chemokine suppression on experimental ulcerative colitis in mice. Genet Mol Res. 2014;13:3337-45 pubmed publisher
    The secondary lymphoid tissue chemokine (CCL21) is closely associated with lymphoid homing and anti-tumor immune responses. CCL21 also has a chemotactic effect on intestinal lymphocytes...
  61. Pay S, Musabak U, Simsek I, Erdem H, Pekel A, Sengul A, et al. Synovial lymphoid neogenetic factors in Behçet's synovitis: do they play a role in self-limiting and subacute course of arthritis?. Clin Exp Rheumatol. 2007;25:S21-6 pubmed
    ..self limiting and non-erosive course of arthritis observed in BD, our finding of detection of lower levels of CCL21 and TGF-Beta1 and IFN-Beta in BD patients, seems to prevent the development of LN and chronic inflammation in Behç..
  62. Wolf M, Clark Lewis I, Buri C, Langen H, Lis M, Mazzucchelli L. Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer. Am J Pathol. 2003;162:1183-90 pubmed
    ..and T47D, selectively degrade macrophage inflammatory protein (MIP)-1 alpha (CCL3), MIP-1 beta (CCL4), and SLC (CCL21)...
  63. Shen L, Wang H, Chen P, Yu C, Liang Y, Zhang C. The analytical determination and electrochemiluminescence behavior of amoxicillin. J Food Drug Anal. 2016;24:199-205 pubmed publisher
    A novel electrochemiluminescence (ECL) luminophor of amoxicillin was studied and found to generate ECL following the oxidation or reduction of amoxicillin...
  64. Serra H, Eberhard Y, Martín A, Gallino N, Gagliardi J, Baena Cagnani C, et al. Secondary lymphoid tissue chemokine (CCL21) is upregulated in allergic contact dermatitis. Int Arch Allergy Immunol. 2004;133:64-71 pubmed
    ..The participation of secondary lymphoid tissue chemokine (CCL21) is essential in the induction of the disease due to its expression in lymphatic vessels and ..
  65. Farragher T, Plant D, Flynn E, Eyre S, Bunn D, Thomson W, et al. Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients. Arthritis Care Res (Hoboken). 2010;62:676-82 pubmed publisher
    ..The presence of 2 copies of the risk allele rs2812378 mapping to the CCL21 gene predicted all-cause mortality (hazard ratio [HR] 1.40, 95% confidence interval [95% CI] 1.04-1...
  66. Rodrigues A, Hirata M, Hirata R. Impact of cholesterol on ABC and SLC transporters expression and function and its role in disposition variability to lipid-lowering drugs. Pharmacogenomics. 2009;10:1007-16 pubmed publisher
  67. Jung Y, Kim H, Perry C, Kaech S. CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. Proc Natl Acad Sci U S A. 2016;113:8278-83 pubmed publisher
    C-C receptor 7 (CCR7) is important to allow T cells and dendritic cells to migrate toward CCL19- and CCL21-producing cells in the T-cell zone of the spleen and lymph nodes...
  68. Muniz L, Pacer M, Lira S, Furtado G. A critical role for dendritic cells in the formation of lymphatic vessels within tertiary lymphoid structures. J Immunol. 2011;187:828-34 pubmed publisher
    ..Overexpression of the chemokine CCL21 in the thyroid of transgenic mice leads to formation of lymphoid aggregates containing topologically segregated T ..
  69. Li S, Chen A, Niu X, Liu Z, Du M, Chai Y, et al. In situ generation of electrochemiluminescent DNA nanoflowers as a signal tag for mucin 1 detection based on a strategy of target and mimic target synchronous cycling amplification. Chem Commun (Camb). 2017;53:9624-9627 pubmed publisher
    A sensitive electrochemiluminescent (ECL) aptasensor consisting of a novel ECL signal tag of DNA nanoflowers (DNA NFs) and a highly efficient target conversion strategy for the MUC1 assay was developed, which not only increased the ..
  70. Li G, Zhao J, Li B, Ma J, Zhao Q, Wang X, et al. Associations between CCL21 gene polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis. Rheumatol Int. 2017;37:1673-1681 pubmed publisher
    ..through angiogenesis, which is dependent on endothelial cell activation, migration and proliferation and CCL21 plays an important role in this pathology...
  71. Lian W, Liang J, Shen L, Jin Y, Liu H. Enzymatic logic calculation systems based on solid-state electrochemiluminescence and molecularly imprinted polymer film electrodes. Biosens Bioelectron. 2018;100:326-332 pubmed publisher
    ..The electrochemiluminescence (ECL) intensity peak of polyluminol (PL) of the AM-free MIP films at 0...
  72. Lee H, Korman B, Le J, Kastner D, Remmers E, Gregersen P, et al. Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations. Arthritis Rheum. 2009;60:364-71 pubmed publisher
    ..The aim of this study was to determine whether the genetic variants at 4q27, 6q23, CCL21, TRAF1/C5, and CD40 identified in Caucasians are also associated with RA in a Korean case-control collection...
  73. Ye S, Ye R, Shi Y, Qiu B, Guo L, Huang D, et al. Highly sensitive aptamer based on electrochemiluminescence biosensor for label-free detection of bisphenol A. Anal Bioanal Chem. 2017;409:7145-7151 pubmed publisher
    ..In this study, a simple but sensitive electrochemiluminescence (ECL) biosensor, which combines the characteristics of high selectivity of an aptamer and high sensitivity of ECL, has ..
  74. Hu L, Zheng J, Zhao K, Deng A, Li J. An ultrasensitive electrochemiluminescent immunosensor based on graphene oxide coupled graphite-like carbon nitride and multiwalled carbon nanotubes-gold for the detection of diclofenac. Biosens Bioelectron. 2018;101:260-267 pubmed publisher
    In this study, a novel competition-type electrochemiluminescent (ECL) immunosensor for detecting diclofenac (DCF) was fabricated with graphene oxide coupled graphite-like carbon nitride (GO-g-C3N4) as signal probe ..
  75. Astrup E, Ranheim T, Damås J, Davi G, Santilli F, Jensenius M, et al. Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection. BMC Infect Dis. 2014;14:70 pubmed publisher concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 and CCL21 may play a pathogenic role in rickettsiae infection. Serum levels of CCL19 and CCL21 in patients with R...
  76. Nie Y, Zhang P, Wang H, Zhuo Y, Chai Y, Yuan R. Ultrasensitive Electrochemiluminescence Biosensing Platform for Detection of Multiple Types of Biomarkers toward Identical Cancer on a Single Interface. Anal Chem. 2017;: pubmed publisher
    Electrochemiluminescence (ECL) with high sensitivity and excellent controllability provides a promising approach for ultrasensitive detection of multiple biomarkers...
  77. Lorenz N, Loef E, Kelch I, Verdon D, Black M, Middleditch M, et al. Plasmin and regulators of plasmin activity control the migratory capacity and adhesion of human T cells and dendritic cells by regulating cleavage of the chemokine CCL21. Immunol Cell Biol. 2016;94:955-963 pubmed publisher
    The homeostatic chemokine CCL21 has a pivotal role in lymphocyte homing and compartment localisation within the lymph node, and also affects adhesion between immune cells...
  78. Schaefer M, Morinaga G, Matsui A, Schänzle G, Bischoff D, Sussmuth R. Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes. Drug Metab Dispos. 2018;46:166-177 pubmed publisher
  79. Redondo Muñoz J, José Terol M, Garcia Marco J, Garcia Pardo A. Matrix metalloproteinase-9 is up-regulated by CCL21/CCR7 interaction via extracellular signal-regulated kinase-1/2 signaling and is involved in CCL21-driven B-cell chronic lymphocytic leukemia cell invasion and migration. Blood. 2008;111:383-6 pubmed
    ..chronic lymphocytic leukemia (B-CLL) progression is frequently accompanied by clinical lymphadenopathy, and the CCL21 chemokine may play an important role in this process...
  80. Banas B, Wornle M, Berger T, Nelson P, Cohen C, Kretzler M, et al. Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J Immunol. 2002;168:4301-7 pubmed
    ..we found the chemokine receptor CCR7 expressed in a mesangial pattern while the CCR7 ligand SLC/CCL21 showed a podocyte-specific expression...
  81. Badr G, Borhis G, Treton D, Moog C, Garraud O, Richard Y. HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21. J Immunol. 2005;175:302-10 pubmed
    ..X4 and X4/R5 gp120 inhibited B cell chemotaxis toward CXCL12, CCL20, and CCL21 by 40-50%, whereas R5 gp120 decreased inhibition by 20%...
  82. Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry M, et al. CCR7 is involved in the migration of neutrophils to lymph nodes. Blood. 2011;117:1196-204 pubmed publisher
    ..In vitro, stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21. In vivo, injection of complete Freund adjuvant induces a rapid recruitment of neutrophils to the lymph nodes in ..
  83. Liang W, Zhuo Y, Xiong C, Zheng Y, Chai Y, Yuan R. A sensitive immunosensor via in situ enzymatically generating efficient quencher for electrochemiluminescence of iridium complexes doped SiO2 nanoparticles. Biosens Bioelectron. 2017;94:568-574 pubmed publisher
    A sensitive electrochemiluminescent (ECL) sandwich immunosensor was proposed herein based on the tris (2-phenylpyridine) iridium [Ir(ppy)3] doped silica nanoparticles (SiO2@Ir) with improved ECL emission as signal ..
  84. Dong Y, Wang J, Peng Y, Zhu J. A novel aptasensor for lysozyme based on electrogenerated chemiluminescence resonance energy transfer between luminol and silicon quantum dots. Biosens Bioelectron. 2017;94:530-535 pubmed publisher
    In the present work, electrogenerated chemiluminescence (ECL) of luminol was investigated in neutral condition at a gold electrode in the presence of silicon quantum dots (SiQDs)...
  85. Bardi G, Niggli V, Loetscher P. Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes. FEBS Lett. 2003;542:79-83 pubmed response to the CCR7 ligands EBI1 ligand chemokine (ELC; CCL19) and secondary lymphoid-tissue chemokine (SLC; CCL21). Both Rho kinase protein isoforms are expressed in T lymphocytes...
  86. Jasmin S, Pearson V, Lalonde D, Domenger D, Theroux L, Poirier J. Differential regulation of ABCA1 and ABCG1 gene expressions in the remodeling mouse hippocampus after entorhinal cortex lesion and liver-X receptor agonist treatment. Brain Res. 2014;1562:39-51 pubmed publisher
    Entorhinal cortex lesioning (ECL) causes an extensive deafferentation of the hippocampus that is classically followed by a compensatory reinnervation, where apolipoprotein E, the main extracellular lipid-carrier in the CNS, has been ..
  87. Shi M, Chen D, Yang D, Liu X. CCL21-CCR7 promotes the lymph node metastasis of esophageal squamous cell carcinoma by up-regulating MUC1. J Exp Clin Cancer Res. 2015;34:149 pubmed publisher
    ..The expression of CCR7 and MUC1 in ESCC cell lines was detected by qRT-PCR and western blot. The effect of CCL21 on the migration and invasion of ESCC cells was determined by transwell assay...
  88. Zhu W, Saddam Khan M, Cao W, Sun X, Ma H, Zhang Y, et al. Ni(OH)2/NGQDs-based electrochemiluminescence immunosensor for prostate specific antigen detection by coupling resonance energy transfer with Fe3O4@MnO2 composites. Biosens Bioelectron. 2018;99:346-352 pubmed publisher
    An efficient quenching electrochemiluminescence (ECL) immunosensor based on ECL resonance energy transfer (ECL-RET) was studied for sensitive analysis of prostate specific antigen (PSA)...
  89. Bax M, van Vliet S, Litjens M, Garcia Vallejo J, van Kooyk Y. Interaction of polysialic acid with CCL21 regulates the migratory capacity of human dendritic cells. PLoS ONE. 2009;4:e6987 pubmed publisher
    ..Subsequently, they migrate as mature DCs (mDCs) to draining lymph nodes to activate T cells. CCR7 and CCL21 contribute to the migratory capacity of the DC, but it is not completely understood what molecular requirements ..
  90. Shibata H, Nishimura K, Miyama C, Tada M, Suzuki T, Saito Y, et al. Comparison of different immunoassay methods to detect human anti-drug antibody using the WHO erythropoietin antibody reference panel for analytes. J Immunol Methods. 2018;452:73-77 pubmed publisher
    ..of three ligand-binding assay methods for ADA, namely, surface plasmon resonance (SPR), electrochemiluminescence (ECL), and biolayer interferometry (BLI) methods, by using the anti-erythropoietin (EPO) monoclonal antibody reference ..
  91. Gosling J, Dairaghi D, Wang Y, Hanley M, Talbot D, Miao Z, et al. Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000;164:2851-6 pubmed
    ..Adhesion was abolished in the presence of soluble ELC, SLC (CCR7 ligands), and TECK (a CCR9 ligand)...