CCL19

Summary

Gene Symbol: CCL19
Description: C-C motif chemokine ligand 19
Alias: CKb11, ELC, MIP-3b, MIP3B, SCYA19, C-C motif chemokine 19, CC chemokine ligand 19, CK beta-11, EBI1-ligand chemokine, MIP-3-beta, beta chemokine exodus-3, chemokine (C-C motif) ligand 19, epstein-Barr virus-induced molecule 1 ligand chemokine, exodus-3, macrophage inflammatory protein 3-beta, small inducible cytokine subfamily A (Cys-Cys), member 19, small-inducible cytokine A19
Species: human
Products:     CCL19

Top Publications

  1. Ott T, Lio F, Olshefski D, Liu X, Ling N, Struthers R. The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19. Biochem Biophys Res Commun. 2006;348:1089-93 pubmed
    ..regulates the trafficking of leucocytes to the secondary lymphoid organs, has two endogenous chemokine ligands: CCL19 and CCL21...
  2. Saleh S, Solomon A, Wightman F, Xhilaga M, Cameron P, Lewin S. CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency. Blood. 2007;110:4161-4 pubmed
    ..of resting CD4(+) T cells, we infected purified resting CD4(+) T cells after incubation with the chemokines CCL19 and CCL21. Incubation with CCL19 or CCL21 did not alter markers of T-cell activation or proliferation...
  3. Yamashita M, Iwama N, Date F, Shibata N, Miki H, Yamauchi K, et al. Macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal. Hum Pathol. 2009;40:1553-63 pubmed publisher
    ..Dual immunostaining showed the coexpression of CCL19-a ligand for CCR7-on the lymphatic endothelium...
  4. Damas J, Øktedalen O, Ueland T, Landrø L, Barstad J, Muller F, et al. Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS). Clin Exp Immunol. 2012;167:492-8 pubmed publisher
    ..and dendritic cells to lymphoid tissue and to promote inflammation, we hypothesized a role for dysregulated CCL19 and CCL21 levels in human immunodeficiency virus (HIV)-infected patients with advanced immunodeficiency, and in ..
  5. Sellam J, Rouanet S, Hendel Chavez H, Miceli Richard C, Combe B, Sibilia J, et al. CCL19, a B cell chemokine, is related to the decrease of blood memory B cells and predicts the clinical response to rituximab in patients with rheumatoid arthritis. Arthritis Rheum. 2013;65:2253-61 pubmed publisher
    ..Serum CCL19, CXCL12, and CXCL13 chemokine levels in patients and controls were determined by enzyme-linked immunosorbent assay...
  6. Castoro C, Le Moli R, Arpi M, Tavarelli M, Sapuppo G, Frittitta L, et al. Association of autoimmune thyroid diseases, chronic atrophic gastritis and gastric carcinoid: experience from a single institution. J Endocrinol Invest. 2016;39:779-84 pubmed publisher
    ..gastric carcinoid and adenocarcinoma as a result of chronic hypergastrinemia caused by achlorhydria and subsequent ELC cells neoplastic transformation...
  7. Li Y, Eskelund A, Zhou H, Budac D, Sánchez C, Gulinello M. Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE). Int J Mol Sci. 2015;16:15150-71 pubmed publisher
    ..interferon γ-inducible protein 10 (IP-10/CXCL10), lymphotactin, macrophage inhibitory protein 3β (MIP-3β/CCL19), monocyte chemotactic protein 1, 3 and 5 (MCP-1/CCL2, MCP-3/CCL7, MCP-5/CCL12), vascular cell adhesion molecule 1 ..
  8. Hawley K, Cruz A, Benjamin S, La Vake C, Cervantes J, Ledoyt M, et al. IFN? Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages. Front Immunol. 2017;8:1227 pubmed publisher
    ..enhanced production of cytokines, macrophage activation markers (CD40, CD80), TLRs (TLR2, TLR7, TLR8), chemokines (CCL19, CXCL10, CXCL11), and TH1-promoting cytokines (IL-12, IL-15)...
  9. Lo T, Silveira P, Fromm P, Verma N, Vu P, Kupresanin F, et al. Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. J Immunol. 2016;197:885-98 pubmed publisher
    ..wild-type DC had an equivalent capacity to undergo maturation, prime T cells, uptake Ags, and migrate toward the CCL19/CCL21 chemokines...

More Information

Publications122 found, 100 shown here

  1. Ponda M, Breslow J. Serum stimulation of CCR7 chemotaxis due to coagulation factor XIIa-dependent production of high-molecular-weight kininogen domain 5. Proc Natl Acad Sci U S A. 2016;113:E7059-E7068 pubmed publisher
    ..CCR7-dependent chemotaxis requires either of the cognate ligands C-C chemokine ligand 19 (CCL19) or CCL21...
  2. Chio C, Lin H, Tian Y, Chen Y, Lin M, Lin C, et al. Exercise attenuates neurological deficits by stimulating a critical HSP70/NF-?B/IL-6/synapsin I axis in traumatic brain injury rats. J Neuroinflammation. 2017;14:90 pubmed publisher
    ..also upregulated the following 14 anti-inflammatory and/or neuroregenerative mRNAs in the peripheral blood such as Ccl19, Ccl3, Cxcl19, IL-10, IL-22, IL-6, Bmp6, Ccl22, IL-7, Bmp7, Ccl2, Ccl17, IL-1rn, and Gpi...
  3. Seleznik G, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, et al. Lymphotoxin ? receptor signaling promotes development of autoimmune pancreatitis. Gastroenterology. 2012;143:1361-1374 pubmed publisher
    ..in pancreatic tissues from patients with AIP, compared with controls, and expression of chemokines (CXCL13, CCL19, CCL21, CCL1, and B-cell-activating factor) was increased in pancreatic and serum samples from patients...
  4. Jung J, Kim E, Kwon G, Jung Y, Park T, Kim Y, et al. β-Caryophyllene potently inhibits solid tumor growth and lymph node metastasis of B16F10 melanoma cells in high-fat diet-induced obese C57BL/6N mice. Carcinogenesis. 2015;36:1028-39 pubmed publisher
    ..HFD feeding increased the levels of CCL19 and CCL21 in the LN and the expression of CCR7 in the tumor; these changes were blocked by dietary BCP...
  5. Olguin Alor R, de la Fuente Granada M, Bonifaz L, Antonio Herrera L, Garcia Zepeda E, Soldevila G. A Key Role for Inhibins in Dendritic Cell Maturation and Function. PLoS ONE. 2016;11:e0167813 pubmed publisher
    ..In addition, Inh?-/- mBMDC showed impaired migration towards CCL19 and CCL21, assessed by in vitro chemotaxis and in vivo competitive homing experiments, despite their normal CCR7 ..
  6. Clatworthy M, Aronin C, Mathews R, Morgan N, Smith K, Germain R. Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes. Nat Med. 2014;20:1458-63 pubmed publisher
    ..In vitro, IC-stimulated mouse and human DCs showed greater directional migration in a chemokine (C-C) ligand 19 (CCL19) gradient and increased chemokine (C-C) receptor 7 (CCR7) expression...
  7. Pranzatelli M, Tate E, Allison T. Case-control, exploratory study of cerebrospinal fluid chemokines/cytokines and lymphocyte subsets in childhood Tourette syndrome with positive streptococcal markers. Cytokine. 2017;96:49-53 pubmed publisher
    ..chemoattractants CXCL13, CXCL10; the B cell proliferation/survival cytokines BAFF and APRIL, or other chemokines (CCL19, CCL21, CCL22). None of the patients had positive CSF oligoclonal bands or an abnormal IgG index/synthesis rate...
  8. Wang G, van Driel B, Liao G, O Keeffe M, Halibozek P, Flipse J, et al. Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8. PLoS ONE. 2015;10:e0121968 pubmed publisher
    ..of Slamf1 and Slamf8 are cell-intrinsic as judged by in vitro migration in transwell chambers in response to CCL19, CCL21 or CSF-1...
  9. Machelart A, Khadrawi A, Demars A, Willemart K, De Trez C, Letesson J, et al. Chronic Brucella Infection Induces Selective and Persistent Interferon Gamma-Dependent Alterations of Marginal Zone Macrophages in the Spleen. Infect Immun. 2017;85: pubmed publisher
    ..tumor necrosis factor alpha receptor 1 (TNF-αR1) signaling pathways and is not correlated to an alteration of CCL19, CCL21, and CXCL13 chemokine mRNA expression...
  10. Termini J, Gupta S, Raffa F, Guirado E, Fischl M, Niu L, et al. Epstein Barr virus Latent Membrane Protein-1 enhances dendritic cell therapy lymph node migration, activation, and IL-12 secretion. PLoS ONE. 2017;12:e0184915 pubmed publisher
    ..Ad5-LMP1 was found to mature and activate both human and mouse DC. LMP1 enhanced in vitro migration of DC toward CCL19, as well as in vivo migration of DC to the inguinal lymph nodes of mice following intradermal injection...
  11. Trogan E, Feig J, Dogan S, Rothblat G, Angeli V, Tacke F, et al. Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Proc Natl Acad Sci U S A. 2006;103:3781-6 pubmed
    ..Remarkably, when CCR7 function was abrogated in vivo by treatment of WT recipients with antibodies to CCR7 ligands CCL19 and CCL21, lesion size and foam cell content were substantially preserved...
  12. Kanatani S, Uhlén P, Barragan A. Infection by Toxoplasma gondii Induces Amoeboid-Like Migration of Dendritic Cells in a Three-Dimensional Collagen Matrix. PLoS ONE. 2015;10:e0139104 pubmed publisher
    ..Toxoplasma-induced hypermigration of DCs was further potentiated in the presence of the CCR7 chemotactic cue CCL19. Blocking antibodies to integrins (CD11a, CD11b, CD18, CD29, CD49b) insignificantly affected migration of infected ..
  13. Wei Y, Liu J, Zhang H, Du X, Luo Q, Sun J, et al. Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model. Environ Toxicol Pharmacol. 2016;46:55-61 pubmed publisher
    ..In addition, ligustrazine significantly reduces IL-4, IL-5, IL-17A, CCL3, CCL19 and CCL21 level in BALF of asthma mice...
  14. Ma Y, Yang M, He Z, Fan M, Huang M, Teng F, et al. Upregulation of heme oxygenase-1 in Kupffer cells blocks mast cell degranulation and inhibits dendritic cell migration in vitro. Mol Med Rep. 2017;15:3796-3802 pubmed publisher
    ..When co‑cultured with MCs, the expression of CCR7 on DCs was reduced, and PGE2, CCL19 and CCL21 were similarly decreased. DC migration was also impaired...
  15. van de Ven R, Reurs A, Wijnands P, van Wetering S, Kruisbeek A, Hooijberg E, et al. Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy. Cancer Immunol Immunother. 2012;61:181-191 pubmed publisher
    ..were as capable as standard 9-day differentiated and matured DC to migrate toward the lymph node-homing chemokines CCL19 and CCL21, to induce primary allogeneic T cell proliferation, and to prime functional MART1-specific CD8(+) T ..
  16. Han Y, Li X, Zhou Q, Jie H, Lao X, Han J, et al. FTY720 Abrogates Collagen-Induced Arthritis by Hindering Dendritic Cell Migration to Local Lymph Nodes. J Immunol. 2015;195:4126-35 pubmed publisher
    ..Decreased secretion of CCL19 and downregulation of CCR7 on DCs may explain the mechanisms underlying the impairment of DC migration induced by ..
  17. Chabot V, Martin L, Meley D, Sensebe L, Baron C, Lebranchu Y, et al. Unexpected impairment of TNF-?-induced maturation of human dendritic cells in vitro by IL-4. J Transl Med. 2016;14:93 pubmed publisher
    ..Importantly, IL-4 impaired the in vitro migratory capacity of DCs in response to CCL21 and CCL19 chemokines. This effect was related to reduced expression of CCR7 at both mRNA and protein levels...
  18. Rump L, Mattey D, Kehoe O, Middleton J. An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine. 2017;97:133-140 pubmed publisher
    ..3% of RA blood vessels and the most abundant being CCL19 which was present in 80%. Of the 26 chemokines studied, 19 have not been previously observed in RA ECs...
  19. Aguilera Montilla N, Chamorro S, Nieto C, Sanchez Cabo F, Dopazo A, Fernández Salguero P, et al. Aryl hydrocarbon receptor contributes to the MEK/ERK-dependent maintenance of the immature state of human dendritic cells. Blood. 2013;121:e108-17 pubmed publisher
    ..ERK inhibition altered the expression of genes that mediate Chemokine (C-C motif) ligand 19 (CCL19)-directed migration (CCR7) and low-density lipoprotein (LDL) binding (CD36, SCARB1, OLR1, CXCL16) by immature DCs...
  20. Hsu Y, Wang M, Ho L, Lai J. Dengue virus infection induces interferon-lambda1 to facilitate cell migration. Sci Rep. 2016;6:24530 pubmed publisher
    ..and its receptor IFN-?R1 through siRNA interference reduced DENV-induced DC migration towards the chemoattractants CCL19 and CCL21, by inhibiting CCR7 expression. Furthermore, IFN-?1 itself induced CCR7 expression and DC migration...
  21. Liu F, Safdar J, Li Z, Fang Q, Zhang X, Xu Z, et al. CCR7 regulates cell migration and invasion through MAPKs in metastatic squamous cell carcinoma of head and neck. Int J Oncol. 2014;45:2502-10 pubmed publisher
    ..The results showed stimulation of CCL19 and the activation of CCR7 could induce ERK1/2 and JNK phosphorylation, while it had no efect on p38...
  22. Dytrych P, Krol P, Petra D, Petra K, Kotrová M, Kuzilkova D, et al. Polyclonal, newly derived T cells with low expression of inhibitory molecule PD-1 in tonsils define the phenotype of lymphocytes in children with Periodic Fever, Aphtous Stomatitis, Pharyngitis and Adenitis (PFAPA) syndrome. Mol Immunol. 2015;65:139-47 pubmed publisher
    ..The expression levels of CXCL10, CXCL9 and CCL19 genes were significantly higher in PFAPA tonsils. The IGH/TCR pattern showed no clonal/oligoclonal expansion...
  23. Paradis A, Bernier S, Dumais N. TLR4 induces CCR7-dependent monocytes transmigration through the blood-brain barrier. J Neuroimmunol. 2016;295-296:12-7 pubmed publisher
    ..CCR7 function was monitored using migration and transmigration assays in response to CCL19/CCL21, which are natural ligands for CCR7...
  24. Tal A, Klein I, Katz R. Inertial Navigation System/Doppler Velocity Log (INS/DVL) Fusion with Partial DVL Measurements. Sensors (Basel). 2017;17: pubmed publisher
    ..the measured partial raw data of the DVL and additional information, thereby deriving an extended loosely coupled (ELC) approach. The implementation of the ELC approach requires only software modification...
  25. Kim S, Han S, Lee H, Kim Y, Choi E, Kim M. Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice. Immunobiology. 2016;221:871-8 pubmed publisher
    ..display impaired T zone structure resulting from decreased splenic expression of the T cell homing chemokines, CCL19 and CCL21. Prions are transported to, and colonise in, the secondary lymphoid tissues...
  26. Hua J, Stevenson W, Dohlman T, Inomata T, Tahvildari M, Calcagno N, et al. Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis. Invest Ophthalmol Vis Sci. 2016;57:1457-67 pubmed publisher
    ..Protein and mRNA expression of the CC chemokine receptor (CCR)7 ligands CCL19 and CCL21 were assessed using ELISA and Real-Time qPCR, respectively...
  27. Fu Q, Yang Y, Li C, Zeng Q, Zhou T, Li N, et al. The chemokinome superfamily: II. The 64 CC chemokines in channel catfish and their involvement in disease and hypoxia responses. Dev Comp Immunol. 2017;73:97-108 pubmed publisher
    ..While only one member of CCL19 (CCL19a.1) was significantly up-regulated after Edwardsiella ictaluri infection, all CCL19 members (CCL19a...
  28. Tycová I, Hrubá P, Maixnerová D, Girmanová E, Mrázová P, Straňavová L, et al. Molecular profiling in IgA nephropathy and focal and segmental glomerulosclerosis. Physiol Res. 2018;67:93-105 pubmed
    ..8) and in FSGS with lower expression of CCL19 (chemokine (C-C motif) ligand 19) (AUC=0.86)...
  29. Baekkevold E, Yamanaka T, Palframan R, Carlsen H, Reinholt F, von Andrian U, et al. The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J Exp Med. 2001;193:1105-12 pubmed
    ..However, the CC chemokine ELC (Epstein-Barr virus-induced molecule 1 ligand chemokine, or CCL19) shares the same receptor, and ELC transcripts have been observed in the T cell areas of lymphoid organs...
  30. Hsu Y, Wang M, Ho L, Huang C, Lai J. Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus. J Cell Mol Med. 2015;19:1065-76 pubmed publisher
    ..Gal-9 by small interference RNA treatment suppressed DV-stimulated migration of DCs towards the chemoattractants CCL19 and CCL21. In addition, DV-induced IL-12p40 production was reduced after knockdown of Gal-9 in DCs...
  31. Gueugneau M, Coudy Gandilhon C, Meunier B, Combaret L, Taillandier D, Polge C, et al. Lower skeletal muscle capillarization in hypertensive elderly men. Exp Gerontol. 2016;76:80-8 pubmed publisher
    ..In the present study, muscle biopsies from normotensive young (YO) and elderly (ELc) men, and elderly men with hypertension (EL-HT) or metabolic syndrome (EL-MS) were assessed for the number of ..
  32. Hansen M, Met O, Larsen N, Rosenkilde M, Andersen M, Svane I, et al. Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21. Cytotherapy. 2016;18:1187-96 pubmed publisher
    ..In vitro maturation protocols generate DCs with high (type 1 DCs) or low (prostaglandin E2 [PGE2]-DCs) autocrine CCL19 levels, which may potentially interfere with LN homing of DCs...
  33. Manfroi B, McKee T, Mayol J, Tabruyn S, Moret S, Villiers C, et al. CXCL-8/IL8 Produced by Diffuse Large B-cell Lymphomas Recruits Neutrophils Expressing a Proliferation-Inducing Ligand APRIL. Cancer Res. 2017;77:1097-1107 pubmed publisher
    ..In a significant fraction of DLBCL patients, tumor cells constitutively produced the ELC-CXC chemokine CXCL-8 (IL8), enabling them to recruit APRIL-producing blood neutrophils...
  34. Corey D, Rinkevich Y, Weissman I. Dynamic Patterns of Clonal Evolution in Tumor Vasculature Underlie Alterations in Lymphocyte-Endothelial Recognition to Foster Tumor Immune Escape. Cancer Res. 2016;76:1348-53 pubmed publisher
    ..are accompanied by decreases in expression of lymphocyte chemokines CXCL16, CXCL13, CXCL12, CXCL9, CXCL10, and CCL19. These evolutionary patterns in the expressed genetic program within tumor endothelium will have both a ..
  35. Liu N, Larner D, Yao Q, Chun R, Ouyang Y, Zhou R, et al. Vitamin D-deficiency and sex-specific dysregulation of placental inflammation. J Steroid Biochem Mol Biol. 2018;177:223-230 pubmed publisher
    ..In non-pregnant mice LPS induced 28 analytes, with 5 (IL-18, IP-10/CXCL10, MCP-1/CCL2, MIP-1β/CCL4, MIP-3β/CCL19) being highest in DEF mice...
  36. Landi A, Aligodarzi M, Khodadadi A, Babiuk L, van Drunen Littel van den Hurk S. Defining a standard and weighted mathematical index for maturation of dendritic cells. Immunology. 2017;: pubmed publisher
    ..to present antigens and induce proliferation of T cells, and mobility of DCs toward high concentrations of CCL19. Impairment of DC maturation has been suggested as the main reason for infectivity or chronicity of several ..
  37. Weber C, Koenen R. Fine-tuning leukocyte responses: towards a chemokine 'interactome'. Trends Immunol. 2006;27:268-73 pubmed
    ..This model could establish how signals conferred by various chemokines are integrated for the combinatorial control of leukocyte responses. ..
  38. Wang Y, Ajtai K, Burghardt T. Ventricular myosin modifies in vitro step-size when phosphorylated. J Mol Cell Cardiol. 2014;72:231-7 pubmed publisher
    ..The myosin lever-arm is stabilized by bound essential and regulatory light chains (ELC and RLC)...
  39. Zhang Q, Gou W, Wang X, Zhang Y, Ma J, Zhang H, et al. Genome Resequencing Identifies Unique Adaptations of Tibetan Chickens to Hypoxia and High-Dose Ultraviolet Radiation in High-Altitude Environments. Genome Biol Evol. 2016;8:765-76 pubmed publisher
    ..JPH2, SATB1, BMP4, LOX, LPR, ANGPTL4, and HYAL1), inflammation and immune responses (AIRE, MYO1F, ZAP70, DDX60, CCL19, CD47, JSC, and FAS), DNA repair, and responses to radiation (VCP, ASH2L, and FANCG) were identified to play key ..
  40. Pathak R, Tibdewal A, G Laskar S, Chaudhari S, Agarwal J. Volume changes with stereotactic body radiation therapy in early lung cancer: Time trends and outcomes. J Med Imaging Radiat Oncol. 2016;60:661-667 pubmed publisher
    ..Twenty-two consecutive patients with early lung cancer (ELC), treated with SBRT, were evaluated retrospectively for their gross tumour volume (GTV) changes during radiation ..
  41. Burghardt T, Sun X, Wang Y, Ajtai K. Auxotonic to isometric contraction transitioning in a beating heart causes myosin step-size to down shift. PLoS ONE. 2017;12:e0174690 pubmed publisher
    ..The 3 and 8 nm unitary step-sizes are dependent on myosin essential light chain (ELC) N-terminus actin binding...
  42. Zhang Y, Tech L, George L, Acs A, Durrett R, Hess H, et al. Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. J Exp Med. 2018;215:1227-1243 pubmed publisher
    ..fibroblastic reticular cells located in the GTI that are also rich in message for IL-6 and chemokines CXCL12, CCL19, and CCL21...
  43. Page G, Lebecque S, Miossec P. Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J Immunol. 2002;168:5333-41 pubmed
    ..We then focused on the expression of CCL20/CCR6 and CCL19/CCR7, CCL21/CCR7 chemokine/receptor complex, which control immature and mature DC migration respectively...
  44. Schlereth S, Lee H, Khandelwal P, Saban D. Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis. Am J Pathol. 2012;180:2351-60 pubmed publisher
    ..However, the CCR7-CCL19/CCL21 system in the ocular surface is poorly understood as is the precise role of DCs in AC immunopathogenesis...
  45. Salimi P, Esmaeili A, Hashemi M, Behjati M. Endogenous expression of the atypical chemokine receptor CCX-CKR (CCRL1) gene in human embryonic kidney (HEK 293) cells. Mol Cell Biochem. 2016;412:229-33 pubmed publisher
    CCX-CKR (CCRL1) as one of the chemokine receptor-like proteins is a scavenger of CCL19, CCL21, CCL25, and CXCL13 chemokines. Human CCX-CKR is expressed in various tissues...
  46. Bojanic K, Grubic M, Bogdanic A, Vukovic J, Weingarten T, Huebner A, et al. Neurocognitive outcomes in congenital diaphragmatic hernia survivors: a cross-sectional prospective study. J Pediatr Surg. 2016;51:1627-34 pubmed publisher
    ..Overall cognitive score was tested with the early learning composite (ELC) of Mullen Scales of Early Learning (n=19), and Full Scale IQ (FSIQ) of Wechsler Intelligence Scale for Children-..
  47. Jafarnejad M, Zawieja D, Brook B, Nibbs R, Moore J. A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4. J Immunol. 2017;199:2291-2304 pubmed publisher
    ..It is activated by chemokines CCL19 and CCL21, which are scavenged by the atypical chemokine receptor ACKR4...
  48. Jeong K, Choi J. [Effect of Debriefing Based on the Clinical Judgment Model on Simulation Based Learning Outcomes of End-of-Life Care for Nursing Students: A Non-Randomized Controlled Trial]. J Korean Acad Nurs. 2017;47:842-853 pubmed publisher
    ..performance, clinical judgment, self-confidence and learner satisfaction during simulation based end-of-life care (ELC) education...
  49. Larsson A, Carlsson L, Lind A, Gordh T, Bodolea C, Kamali Moghaddam M, et al. The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid. Cytokine. 2015;76:514-518 pubmed publisher
    ..markers were significantly associated with BMI (in decreasing significance: FGF-5, ADA, Beta-NGF, CD40, IL-10RB, CCL19, TGF-alpha, SIRT2, TWEAK, SCF, CSF-1, 4E-BP1, DNER, LIF-R, STAMPB, CXCL10, CXCL6, VEGF-A and CX3CL1)...
  50. Lokensgard J, Mutnal M, Prasad S, Sheng W, Hu S. Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection. J Neuroinflammation. 2016;13:114 pubmed publisher
    ..and CXCL13, as well as CCL5, were found within the brains of infected animals, and only low levels of CCL3 and CCL19 were detected...
  51. Connelly K, Kandane Rathnayake R, Hoi A, Nikpour M, Morand E. Association of MIF, but not type I interferon-induced chemokines, with increased disease activity in Asian patients with systemic lupus erythematosus. Sci Rep. 2016;6:29909 pubmed publisher
    ..Serum MIF, and a validated composite score of three Type I IFN-inducible chemokines (IFNCK:CCL2, CXCL10, CCL19) were measured...
  52. Jørgensen A, Rosenkilde M, Hjortø G. Biased signaling of G protein-coupled receptors - From a chemokine receptor CCR7 perspective. Gen Comp Endocrinol. 2018;258:4-14 pubmed publisher
    ..Together with its two endogenous ligands CCL19 and CCL21, of which the carboxy terminal tail of CCL21 displays an extraordinarily strong glycosaminoglycan (GAG) ..
  53. Daikoku N, Kitaya K, Nakayama T, Fushiki S, Honjo H. Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle. Fertil Steril. 2004;81 Suppl 1:876-81 pubmed
    ..MIP-3beta was expressed in the human endometrium, but our results could not strongly support the hypothesis that MIP-3beta is a potential chemoattractant for endometrial NK cells. ..
  54. Aligisakis M, Marques Vidal P, Guessous I, Vollenweider P. Did Dumbo suffer a heart attack? independent association between earlobe crease and cardiovascular disease. BMC Cardiovasc Disord. 2016;16:17 pubmed publisher
    Earlobe crease (ELC) has been associated with cardiovascular diseases (CVD) or risk factors (CVRF) and could be a marker predisposing to CVD...
  55. Anderson J, Mota T, Evans V, Kumar N, Rezaei S, Cheong K, et al. Understanding Factors That Modulate the Establishment of HIV Latency in Resting CD4+ T-Cells In Vitro. PLoS ONE. 2016;11:e0158778 pubmed publisher
    ..Using the CCL19 model of HIV latency, we found that in up to 50% of donors, CCL19 enhanced latent infection of resting CD4+ T-..
  56. Adnan E, Matsumoto T, Ishizaki J, Onishi S, Suemori K, Yasukawa M, et al. Human tolerogenic dendritic cells generated with protein kinase C inhibitor are optimal for functional regulatory T cell induction - A comparative study. Clin Immunol. 2016;173:96-108 pubmed publisher
    ..All tDCs had a semi-mature DC phenotype. PKCI-, TGF-?-, and Rapa-tDCs showed CCR7 expression and migration to CCL19, but other tDCs showed little or none...
  57. Zhang Z, Liu F, Li Z, Wang D, Li R, Sun C. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017;13:3191-3197 pubmed publisher
    ..In addition, when the PCI-37B cells were analyzed in response to chemokine ligand 19 (CCL19), the ligand of CCR7, at the indicated time points, the results of the present study demonstrated that CCR7 ..
  58. Climent N, Munier S, Piqué N, García F, Pavot V, Primard C, et al. Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses. Vaccine. 2014;32:6266-76 pubmed publisher
    ..induced a slight degree of MDDC maturation, cytokine and chemokine secretion and migration towards a gradient of CCL19 chemokine and highly increased HIV-specific CD8(+) T-cell proliferation compared with p24 alone...
  59. Arruga F, Gizdić B, Bologna C, Cignetto S, Buonincontri R, Serra S, et al. Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22. Leukemia. 2017;31:1882-1893 pubmed publisher
    ..CLL patients with a NOTCH1-mutated clone showed low levels of DUSP22 and active chemotaxis to CCL19. Lastly, in xenograft models, NOTCH1-mutated cells displayed a unique homing behavior, localizing preferentially ..
  60. Liu S, Wu J, Zhang T, Qian B, Wu P, Li L, et al. Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways. Mol Immunol. 2008;46:242-9 pubmed publisher
    ..Additionally, C1q significantly enhances the chemotaxis of LPS-induced mature DC to CCL19 via upregulation of CCR7 expression...
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    ..Expression of chemokine (c-c-motif) ligand 19 (CCL19) was significantly upregulated in plaques from patients with clinically unstable disease (p < .001)...
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    ..The present study shows that a CC chemokine CCL19 attracts mature T cells out of the fetal thymus organ culture...
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    ..Overall, our results indicate that chemokine-induced synergism strengthens leukocyte recruitment towards tissues co-expressing several chemokines. ..
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    ..Mononuclear cells surrounding the blood vessels of inflamed muscle contained abundant transcripts of CCL19 and CCL21, but very little CCL18 transcripts...
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    ..pneumoniae-matured DC, resulting in an enhanced migratory responsiveness to the lymph node-associated chemokine CCL19. Bacterial fragment-matured DC do not only mediate NK-cell migration but also meet the prerequisites needed for ..
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    ..0001). CrkL and c-ABL mRNA expressions were influenced by EGFR mutations. A high expression of CCL19 was a good prognostic factor of lung adenocarcinoma...
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    ..was aimed at evaluating the levels of six chemokines--CXCL8 (IL-8), CXCL12 (SDF-1), CCL2 (MCP-1), CCL5 (RANTES), CCL19 (MIP-3β), and CCL21 (6-Ckine)--in the peritoneal fluid (PF) of patients with and controls without endometriosis ..
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    ..interleukins IL-5 (?8-fold) and IL-6; (2) an increased Fk expression that in turn induces expression of: CXCL17, CCL19, CCL2, CXCL10, CXCL12, CXCL4, CXCL7, CCL4, CCL18, CXCL16, CXCL1 and IL-27; (3) in the presence of Rs, a ..
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    ..effects can be distinguished from those triggered by LPS, as both agents oppositely regulate the expression of CCL19 and TRIB3 Besides, palmitate conditions macrophages for exacerbated proinflammatory responses (lower IL-10 ..
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    ..CCR7 and its ligands CCL19 and CCL21 are a chemokine system related to mononuclear cell migration and antigen presentation, and are suggested ..
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    ..By specifically degrading G?(i2), Nef directly subverts leukocyte migration and homing. Impaired trafficking and homing of HIV Nef-expressing lymphocytes probably contributes to early immune dysfunction following HIV infection. ..
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    It is well-documented that both chemokine (C-C motif) ligand 19 (CCL19) and 21 (CCL21) mediate cell migration and angiogenesis in many diseases...
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    C-C receptor 7 (CCR7) is important to allow T cells and dendritic cells to migrate toward CCL19- and CCL21-producing cells in the T-cell zone of the spleen and lymph nodes...
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    ..The grouping of CD8?+ cells may be explained by the greater expression of CCL19, ICAM-1, and VCAM-1 in the mucosal tip compared with the neuroepithelium...
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    ..PRM analyses confirmed significant nodule-specific abundance of 10 proteins including ALOX5, ALOX5AP, CCL19, CILP1, COL5A2, ITGB2, ITGAX, PTPRE, S100A12, and SLC2A3 and significant ADC-specific abundance of CEACAM6, CRABP2,..
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    ..kinase (ERK)-2 in the polarization and migration of T lymphocytes in response to the CCR7 ligands EBI1 ligand chemokine (ELC; CCL19) and secondary lymphoid-tissue chemokine (SLC; CCL21)...
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    ..Furthermore, we show that the addition of CXCL13 to CCL19 or to CCL21, the selective CCR7 agonists responsible for lymph node homing, strongly enhances the migration of ..
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    ..In contrast with other CC chemokines, MIP-3beta maps to chromosome 9. Here we show the importance of bioinformatics to discover new molecules with possible therapeutic effects and regulatory functions. ..
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    ..Activated DCs home to lymphoid organs, where the CCR7 ligands CCL19 and CCL21 are expressed...
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    ..Chemokine-induced synergism might provide an amplification system in "chemokine-rich" tissues, rendering leukocytes more competent to respond to migratory cues. ..
  86. Jongen Lavrencic M, Salesse S, Delwel R, Verfaillie C. BCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cells. Leukemia. 2005;19:373-80 pubmed
    ..Compared with GFP UCB or normal (NL) BM CD34+ cells, p210 UCB and CML CD34+ cells migrated poorly towards the CCR7 ligands, CCL19 and CCL21, suggesting a possible role for CCR7 in the abnormal migratory behavior of CML CD34+ cells.
  87. Wang X, Yuling H, Yanping J, Xinti T, Yaofang Y, Feng Y, et al. CCL19 and CXCL13 synergistically regulate interaction between B cell acute lymphocytic leukemia CD23+CD5+ B Cells and CD8+ T cells. J Immunol. 2007;179:2880-8 pubmed
    ..In a previous study, we have reported that ligation of CCL19-CCR7 and CXCL13-CXCR5 activates paternally expressed gene 10 (PEG10), resulting in an enhancement of apoptotic ..
  88. König K, Diehl L, Rommerscheidt Fuss U, Golletz C, Quast T, Kahl P, et al. Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration. J Immunol. 2010;185:1466-75 pubmed publisher
    We identified the four-and-a-half LIM domain protein 2 (FHL2) as a novel regulator of CCL19-induced dendritic cell (DC) migration...
  89. Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, Loiry M, et al. CCR7 is involved in the migration of neutrophils to lymph nodes. Blood. 2011;117:1196-204 pubmed publisher
    ..In vitro, stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21...
  90. Astrup E, Ranheim T, Damås J, Davi G, Santilli F, Jensenius M, et al. Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection. BMC Infect Dis. 2014;14:70 pubmed publisher
    ..role in concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 and CCL21 may play a pathogenic role in rickettsiae infection. Serum levels of CCL19 and CCL21 in patients with R...
  91. Cai W, Tao J, Zhang X, Tian X, Liu T, Feng X, et al. Contribution of homeostatic chemokines CCL19 and CCL21 and their receptor CCR7 to coronary artery disease. Arterioscler Thromb Vasc Biol. 2014;34:1933-41 pubmed publisher
    Our aim was to identify the role of the homeostatic chemokines CCL19 and CCL21 and their common receptor CCR7 in atherogenesis and to study the relationships between CCL19, CCL21, and CCR7 gene variants and coronary artery disease in a ..
  92. Yu H, Sung M, Kuo H, Lin C, Chen C. Shear Stress Modulates Resistin-Induced CC Chemokine Ligand 19 Expression in Human Aortic Endothelial Cells. J Cell Physiol. 2015;230:2120-7 pubmed publisher
    ..Recent studies have suggested an association between resistin and atherogenic processes. In addition, CCL19 is highly expressed in human atherosclerotic lesions...