CCDC88B

Summary

Gene Symbol: CCDC88B
Description: coiled-coil domain containing 88B
Alias: BRLZ, CCDC88, HKRP3, gipie, coiled-coil domain-containing protein 88B, 78 kDa glucose-regulated protein [GRP78]-interacting protein induced by ER stress, GRP78-interacting protein induced by ER stress, brain leucine zipper domain-containing protein, brain leucine zipper protein, coiled-coil domain containing 88, hook-related protein 3
Species: human
Products:     CCDC88B

Top Publications

  1. Kennedy J, Fodil N, Torre S, Bongfen S, Olivier J, Leung V, et al. CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation. J Exp Med. 2014;211:2519-35 pubmed publisher
    ..We identified an ECM-protective mutation in coiled-coil domain containing protein 88b (Ccdc88b), a poorly annotated gene that is found expressed specifically in spleen, bone marrow, lymph nodes, and thymus...
  2. Coleman B, Marivin A, Parag Sharma K, DiGiacomo V, Kim S, Pepper J, et al. Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation. Mol Biol Evol. 2016;33:820-37 pubmed publisher
    ..We recently found that proteins of the ccdc88 family possess a Gα-binding and activating (GBA) motif that confers GEF activity and regulates mammalian cell ..
  3. Wang X, Zhang T, Mao H, Mi Y, Zhong B, Wei L, et al. Grass carp (Ctenopharyngodon idella) ATF6 (activating transcription factor 6) modulates the transcriptional level of GRP78 and GRP94 in CIK cells. Fish Shellfish Immunol. 2016;52:65-73 pubmed publisher
    ..The largest open reading frame of CiATF6 translates into 648 aa with a typical DNA binding domain (BRLZ domain) and shares significant homology to the known ATF6 counterparts...
  4. Wang X, Mi Y, Zhong B, Mao H, Wan Y, Zhang T, et al. Identification of grass carp (Ctenopharyngodon idella) XBP1S as a primary member in ER stress. Fish Shellfish Immunol. 2017;64:84-92 pubmed publisher
    ..open reading frame (1152 bp) encoding a polypeptide of 383 amino acids with a well conserved DNA binding domain (BRLZ domain). CiXBP1S shares significant homology to zebrafish XBP1S (?90%) at amino acid level...
  5. Simpson F, Martin S, Evans T, Kerr M, James D, Parton R, et al. A novel hook-related protein family and the characterization of hook-related protein 1. Traffic. 2005;6:442-58 pubmed
    ..We propose that HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains. ..
  6. Fischer A, Schmid B, Ellinghaus D, Nothnagel M, Gaede K, Schürmann M, et al. A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1. Am J Respir Crit Care Med. 2012;186:877-85 pubmed publisher
    ..For sarcoidosis, fine-mapping and expression analysis suggest KCNK4, PRDX5, PCLB3, and most promising CCDC88B as candidates for the underlying risk gene in the associated region...
  7. Liu H, Irwanto A, Fu X, Yu G, Yu Y, Sun Y, et al. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. Nat Genet. 2015;47:267-71 pubmed publisher
    ..discovered six new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy...
  8. Fodil N, Moradin N, Leung V, Olivier J, Radovanovic I, Jeyakumar T, et al. CCDC88B is required for pathogenesis of inflammatory bowel disease. Nat Commun. 2017;8:932 pubmed publisher
    Inflammatory bowel disease (IBD) involves interaction between host genetic factors and environmental triggers. CCDC88B maps within one IBD risk locus on human chromosome 11q13...
  9. Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Mii S, et al. Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells. Mol Biol Cell. 2011;22:736-47 pubmed publisher
    ..Here we show that a novel Girdin family protein, Gipie (78 kDa glucose-regulated protein [GRP78]-interacting protein induced by ER stress), is expressed in endothelial ..

More Information

Publications10

  1. Ham H, Huynh W, Schoon R, Vale R, Billadeau D. HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. J Immunol. 2015;194:3984-96 pubmed publisher
    ..In this study, we identified Hook-related protein 3 (HkRP3) as a novel DOCK8- and MT-binding protein...