CCDC88A

Summary

Gene Symbol: CCDC88A
Description: coiled-coil domain containing 88A
Alias: APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, PEHO, PEHOL, girdin, AKT-phosphorylation enhancer, Hook-related protein 1, g alpha-interacting vesicle-associated protein, girders of actin filament, girders of actin filaments
Species: human
Products:     CCDC88A

Top Publications

  1. Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, et al. A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem. 2005;280:18525-35 pubmed
    ..Thus, we termed this Akt-specific binding protein APE (Akt-phosphorylation enhancer)...
  2. Simpson F, Martin S, Evans T, Kerr M, James D, Parton R, et al. A novel hook-related protein family and the characterization of hook-related protein 1. Traffic. 2005;6:442-58 pubmed
    ..This domain has been shown to bind microtubules in the Hook protein and show that the HkRP1 protein is microtubule-associated...
  3. Weng L, Enomoto A, Ishida Takagishi M, Asai N, Takahashi M. Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis. Cancer Sci. 2010;101:836-42 pubmed publisher
    ..In this review, we focus on the emerging roles of Girdin (also designated KIAA1212, APE, GIV, and HkRP1), a novel component of the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathway that ..
  4. Garcia Marcos M, Kietrsunthorn P, Pavlova Y, Adia M, Ghosh P, Farquhar M. Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling. Proc Natl Acad Sci U S A. 2012;109:1961-6 pubmed publisher
    ..GIV (a.k.a. Girdin) is a unique component of this network and a nonreceptor guanine nucleotide exchange factor (GEF) that functions ..
  5. Le Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar M. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J Biol Chem. 2005;280:22012-20 pubmed
    In this report, we characterize GIV (Galpha-interacting vesicle-associated protein), a novel protein that binds members of the Galpha(i) and Galpha subfamilies of heterotrimeric G proteins...
  6. Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, et al. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell. 2005;9:389-402 pubmed
    ..Here, we identify an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein...
  7. Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, et al. Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Nat Cell Biol. 2008;10:329-37 pubmed publisher
    ..Here we report that Akt-mediated phosphorylation of Girdin, an actin-binding protein, promotes VEGF-dependent migration of endothelial cells and tube formation by these ..
  8. Garcia Marcos M, Ghosh P, Ear J, Farquhar M. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010;285:12765-77 pubmed publisher
    ..Here we investigated the structural determinants in G alpha(i3) necessary for its regulation by GIV/girdin, a guanine-nucleotide exchange factor (GEF) that activates G alpha(i) subunits...
  9. Beas A, Taupin V, Teodorof C, Nguyen L, Garcia Marcos M, Farquhar M. G?s promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin). Mol Biol Cell. 2012;23:4623-34 pubmed publisher
    ..by the heterotrimeric G protein G?s through interaction with the signal transducing protein GIV (also known as Girdin)...

More Information

Publications113 found, 100 shown here

  1. Dunkel Y, Ong A, Notani D, Mittal Y, Lam M, Mi X, et al. STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis. J Biol Chem. 2012;287:41667-83 pubmed publisher
    Gα-interacting vesicle-associated protein (GIV) is a guanine nucleotide exchange factor that modulates key signaling pathways during a diverse set of biological processes, e.g...
  2. López Sánchez I, Dunkel Y, Roh Y, Mittal Y, De Minicis S, Murányi A, et al. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014;5:4451 pubmed publisher
    ..Here we report the discovery of a signalling platform comprising G protein subunit, Gαi and GIV, its guanine exchange factor (GEF), which serves as a central hub within the fibrogenic signalling network ..
  3. Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, Ishida M, et al. An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res. 2008;68:1310-8 pubmed publisher
    Girdin (girders of actin filaments) is a novel actin-binding Akt substrate that plays an important role in actin organization and Akt-dependent cell motility in fibroblasts...
  4. Ghosh P, Garcia Marcos M, Bornheimer S, Farquhar M. Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol. 2008;182:381-93 pubmed publisher
    ..We previously identified GIV/Girdin as a Galphai3 binding partner...
  5. Garcia Marcos M, Ghosh P, Farquhar M. GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A. 2009;106:3178-83 pubmed publisher
    ..We have discovered that GIV/Girdin serves as a nonreceptor GEF for G alpha i through an evolutionarily conserved motif that shares sequence homology ..
  6. Garcia Marcos M, Jung B, Ear J, Cabrera B, Carethers J, Ghosh P. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011;25:590-9 pubmed publisher
    ..We previously reported that GIV/Girdin triggers tumor cell migration by virtue of a C-terminal guanine-nucleotide exchange factor motif that activates G?..
  7. Mittal Y, Pavlova Y, Garcia Marcos M, Ghosh P. Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. J Biol Chem. 2011;286:32404-15 pubmed publisher
    GIV (Gα-interacting vesicle-associated protein, also known as Girdin) is a bona fide enhancer of PI3K-Akt signals during a diverse set of biological processes, e.g...
  8. Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, et al. Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal. 2011;4:ra64 pubmed publisher
    GIV (Gα-interacting vesicle-associated protein; also known as Girdin) enhances Akt activation downstream of multiple growth factor- and G protein (heterotrimeric guanosine 5'-triphosphate-binding protein)-coupled receptors to trigger ..
  9. Ohara K, Enomoto A, Kato T, Hashimoto T, Isotani Sakakibara M, Asai N, et al. Involvement of Girdin in the determination of cell polarity during cell migration. PLoS ONE. 2012;7:e36681 pubmed publisher
    ..Girdin (girders of actin filaments) (also termed GIV, G?-interacting vesicle associated protein) is an actin-binding protein that regulates ..
  10. Ghosh P, Beas A, Bornheimer S, Garcia Marcos M, Forry E, Johannson C, et al. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010;21:2338-54 pubmed publisher
    ..The underlying mechanism of this phenomenon has remained unknown. We demonstrate here that Galpha(i) protein and GIV, its nonreceptor guanine nucleotide exchange factor (GEF), program EGF receptor (EGFR) signaling and orchestrate ..
  11. Garcia Marcos M, Ear J, Farquhar M, Ghosh P. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell. 2011;22:673-86 pubmed publisher
    ..k. a. Girdin), a nonreceptor guanine nucleotide exchange factor for G?(i3), plays a key role in regulating autophagy and that ..
  12. Santos G, Oliveira E, Pinheiro A, da Costa P, de Freitas J, de Araújo Santos F, et al. Himatanthus drasticus (Apocynaceae) latex reduces oxidative stress and modulates CD4+, CD8+, FoxP3+ and HSP-60+ expressions in Sarcoma 180-bearing mice. J Ethnopharmacol. 2018;220:159-168 pubmed publisher
    ..9% saline), GII (S180asc) and GIII (S180asc/HdCL/14 days); 2) solid model, GIV (Control; 0.9% saline), GV (S180sol) and GVI (S180sol/HdCL/10 days). HdCL and 0...
  13. Jia J, Tan Z, Liu M, Jiang Y. Apurinic/apyrimidinic endonuclease 1 (APE1) contributes to resveratrol?induced neuroprotection against oxygen?glucose deprivation and re?oxygenation injury in HT22 cells: Involvement in reducing oxidative DNA damage. Mol Med Rep. 2017;16:9786-9794 pubmed publisher
    ..OGD/R?induced oxidative DNA damage as evidenced by the decreases in the levels of 8?hydroxy?2'?deoxyguanosine and APE sites...
  14. Mayer R, Schwarzmeier J, Gerner M, Bileck A, Mader J, Meier Menches S, et al. Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. Mol Cell Proteomics. 2018;17:290-303 pubmed publisher
    ..molecules PNN and JARID2, the stress-related serotonin transporter SLC6A4, and high expression of ZNF207, CCDC88A, PIGR and ID3, otherwise associated with stem cell phenotype, were determined...
  15. Lowenstine L, McManamon R, Terio K. Comparative Pathology of Aging Great Apes: Bonobos, Chimpanzees, Gorillas, and Orangutans. Vet Pathol. 2016;53:250-76 pubmed publisher
    ..Despite the many similarities, there are significant differences in aging among apes, including the human ape. Common to all are dental attrition, periodontitis, tooth loss, osteopenia, and arthritis, although gout is ..
  16. Sahan E, Karamanlıoğlu M, Şahan S, Gul M, Korkmaz A, Tufekcioglu O. The relationship between right ventricular outflow tract fractional shortening and Pulmonary Embolism Severity Index in acute pulmonary embolism. Turk Kardiyol Dern Ars. 2017;45:709-714 pubmed publisher
    Right ventricular (RV) functions are clinically important in acute pulmonary embolism (APE). Measurement of systolic function of the right ventricular outflow tract (RVOT) with echocardiography is a simple method to evaluate RV function...
  17. Bianco T, Abdalla D, Desidério C, Thys S, Simoens C, Bogers J, et al. The influence of physical activity in the anti-tumor immune response in experimental breast tumor. Immunol Lett. 2017;190:148-158 pubmed publisher
    ..controls without tumor, sedentary (GI) and trained (GII) and two groups with tumor, sedentary (GIII) or trained (GIV). The physical activity (PA) was realized acoording swimming protocol. Tumor was induced by injection of 4T1 cells...
  18. Fihman V, Messika J, Hajage D, Tournier V, Gaudry S, Magdoud F, et al. Five-year trends for ventilator-associated pneumonia: Correlation between microbiological findings and antimicrobial drug consumption. Int J Antimicrob Agents. 2015;46:518-25 pubmed publisher
    ..64 to 10.52 isolates/1000 patient-days; P=0.006], mostly due to an increase in AmpC-producing Enterobacteriaceae (APE) (2.85-4.51 isolates/1000 patient-days; P=0.013), whereas the number of episodes due to S...
  19. Fernandez Cassi X, Timoneda N, Gonzales Gustavson E, Abril J, Bofill Mas S, Girones R. A metagenomic assessment of viral contamination on fresh parsley plants irrigated with fecally tainted river water. Int J Food Microbiol. 2017;257:80-90 pubmed publisher
    ..such as the hepatitis E virus, several picornaviruses from species A and B as well as human sapoviruses and GIV noroviruses were detected...
  20. Miao R, Leng D, Liu M, Huang X, Li J, Gong J, et al. Alteration of endothelial nitric oxide synthase expression in acute pulmonary embolism: a study from bench to bioinformatics. Eur Rev Med Pharmacol Sci. 2017;21:827-836 pubmed
    This study sought to explore endothelial nitric oxide synthase (eNOS) expression in acute pulmonary thromboembolism (APE)...
  21. Caddy S, Breiman A, Le Pendu J, Goodfellow I. Genogroup IV and VI canine noroviruses interact with histo-blood group antigens. J Virol. 2014;88:10377-91 pubmed publisher
    ..noroviruses bind to HBGAs and GV noroviruses recognize terminal sialic acid residues, the attachment factors for GIV and GVI noroviruses have not been reported...
  22. Bai Y, Wang G, Fu W, Lu Y, Wei W, Chen W, et al. Circulating essential metals and lung cancer: Risk assessment and potential molecular effects. Environ Int. 2019;127:685-693 pubmed publisher
    ..In particularly, zinc could regulate the expressions of 8 cancer-related genes, including SOD1, APE, TP53BP1, WDR33, LAPTM4B, TRIT1, HUWE1, and ZNF813, which were over-expressed in lung tumor tissues...
  23. Belhouchet M, Mohd Jaafar F, Firth A, Grimes J, Mertens P, Attoui H. Detection of a fourth orbivirus non-structural protein. PLoS ONE. 2011;6:e25697 pubmed publisher
    ..raised against recombinant NS4 from Bluetongue virus (BTV, which is insect-borne), or Great Island virus (GIV, which is tick-borne), demonstrate that these proteins are synthesised in BTV or GIV infected mammalian cells, ..
  24. Piovesana R, Melfi S, Fiore M, Yi V, Tata A. M2 muscarinic receptor activation inhibits cell proliferation and migration of rat adipose-mesenchymal stem cells. J Cell Physiol. 2017;: pubmed publisher
    ..By using the selective M2 agonist Arecaidine Propargyl Ester (APE) we performed cell proliferation and migration assays demonstrating that APE causes cell growth and migration ..
  25. Lin H, Li C, Yang Y, Chiu T, Liu K, Lii C, et al. Andrographis paniculata diterpenoids and ethanolic extract inhibit TNFα-induced ICAM-1 expression in EA.hy926 cells. Phytomedicine. 2019;52:157-167 pubmed publisher
    ..We showed that pretreatment of EA.hy926 cells with A. paniculata ethanolic extract (APE), deAND, and AND significantly inhibited TNFα-induced ICAM-1 protein and mRNA expression, ICAM-1 promoter activity,..
  26. Paim R, Benjamin S, Rondina D, Marques M, Viana D, Gonzaga M, et al. Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia. Evid Based Complement Alternat Med. 2017;2017:6376173 pubmed publisher
    ..of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family)...
  27. Creixell P, Palmeri A, Miller C, Lou H, Santini C, Nielsen M, et al. Unmasking determinants of specificity in the human kinome. Cell. 2015;163:187-201 pubmed publisher
    ..we systematically discover several DoS and experimentally validate three of them, named the αC1, αC3, and APE-7 residues. We demonstrate that DoS form sparse networks of non-conserved residues spanning distant regions...
  28. Carpelan A, Karvonen J, Varpe P, Rantala A, Kaljonen A, Gronroos J, et al. Extralevator versus standard abdominoperineal excision in locally advanced rectal cancer: a retrospective study with long-term follow-up. Int J Colorectal Dis. 2018;33:375-381 pubmed publisher
    To analyze the results of abdominoperineal excisions (APE) for locally advanced rectal cancer at our institution before and after the adoption of extralevator abdominoperineal excision (ELAPE) with a special reference to long-term ..
  29. Morimoto N, Zollikofer C, Ponce de León M. Shared human-chimpanzee pattern of perinatal femoral shaft morphology and its implications for the evolution of hominin locomotor adaptations. PLoS ONE. 2012;7:e41980 pubmed publisher
    Acquisition of bipedality is a hallmark of human evolution. How bipedality evolved from great ape-like locomotor behaviors, however, is still highly debated...
  30. Singh B, Koromyslova A, Hansman G. Structural analysis of bovine norovirus protruding domain. Virology. 2016;487:296-301 pubmed publisher
    ..The bovine P domain was reminiscent of other norovirus genogroups (GI, GII, GIV, and GV), but closely matched the human GI P domain...
  31. Majdoul S, Seye A, Kichler A, Holic N, Galy A, Bechinger B, et al. Molecular Determinants of Vectofusin-1 and Its Derivatives for the Enhancement of Lentivirally Mediated Gene Transfer into Hematopoietic Stem/Progenitor Cells. J Biol Chem. 2016;291:2161-9 pubmed publisher
    ..enhancement with LVs pseudotyped with vesicular stomatitis virus glycoproteins and also with modified gibbon ape leukemia virus glycoproteins...
  32. Loy D, Liu W, Li Y, Learn G, Plenderleith L, Sundararaman S, et al. Out of Africa: origins and evolution of the human malaria parasites Plasmodium falciparum and Plasmodium vivax. Int J Parasitol. 2017;47:87-97 pubmed publisher
    ..apes, comparative genomics, coupled with functional parasite and vector studies, are likely to yield new insights into ape Plasmodium transmission and pathogenesis that are relevant to the treatment and prevention of human malaria.
  33. Yeh Y, Wang T, Chou H, Lin H, Chen T, Aoki T, et al. A member of the immunoglobulin superfamily, orange-spotted grouper novel immune gene EcVig, is induced by immune stimulants and type I interferon. Fish Shellfish Immunol. 2016;58:415-422 pubmed publisher
    ..acid [poly(I:C)]), as well as fish DNA virus (red sea bream iridovirus, RSIV; grouper iridovirus, GIV), were used to study EcVig responses in orange-spotted grouper...
  34. Gao J, Peng D, Zhang X, Hao Z, Zhou J, Fan S, et al. Prevalence and Associated Factors of Premature Ejaculation in the Anhui Male Population in China: Evidence-Based Unified Definition of Lifelong and Acquired Premature Ejaculation. Sex Med. 2017;5:e37-e43 pubmed publisher
    In 2014, new evidence-based definitions of lifelong premature ejaculation (LPE) and acquired premature ejaculation (APE) were proposed by the International Society for Sexual Medicine...
  35. Malhotra A, Crocker M, Willes L, Kelly C, Lynch S, Benjafield A. Patient Engagement Using New Technology to Improve Adherence to Positive Airway Pressure Therapy: A Retrospective Analysis. Chest. 2018;153:843-850 pubmed publisher
    ..This trial compared positive airway pressure adherence among patients who were provided active patient engagement (APE) technology vs those who received usual care monitoring (UCM)...
  36. Weng L, Enomoto A, Miyoshi H, Takahashi K, Asai N, Morone N, et al. Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin. EMBO J. 2014;33:2098-112 pubmed publisher
    ..Here, we show that the actin-binding protein girdin is a regulator of cargo-selective CME...
  37. Li J, Yang Y, Huan H, Li M, Xi B, Lv N, et al. Method for screening prevention and control measures and technologies based on groundwater pollution intensity assessment. Sci Total Environ. 2016;551-552:143-54 pubmed publisher
    ..The pollution sources hazards (PSH) and groundwater intrinsic vulnerability (GIV) are graded by the revised Nemerow Pollution Index and an improved DRTAS model, respectively...
  38. Figueras J, Bañeras J, Pena Gil C, Barrabés J, Rodríguez Palomares J, Garcia Dorado D. Hospital and 4-Year Mortality Predictors in Patients With Acute Pulmonary Edema With and Without Coronary Artery Disease. J Am Heart Assoc. 2016;5: pubmed publisher
    Long-term prognosis of acute pulmonary edema (APE) remains ill defined...
  39. Reindl E, Beck S, Apperly I, Tennie C. Young children spontaneously invent wild great apes' tool-use behaviours. Proc Biol Sci. 2016;283:20152402 pubmed publisher
    ..and great apes, indicating that the physical cognition underlying tool use shows large overlaps across the great ape species...
  40. Meyer M, Williams S, Schmid P, Churchill S, Berger L. The cervical spine of Australopithecus sediba. J Hum Evol. 2017;104:32-49 pubmed publisher
    ..Yet these derived features in A. sediba are accompanied by ape-like vertebral body and dorsal pillar sizes, articular facet orientation, and uncinate process morphology signaling ..
  41. Mao Y, Wen S, Chen G, Zhang W, Ai Y, Yuan J. Management of intra-operative acute pulmonary embolism during general anesthesia: a case report. BMC Anesthesiol. 2017;17:67 pubmed publisher
    Acute pulmonary embolism (APE) can be life-threatening...
  42. Krupenye C, Hare B. Bonobos Prefer Individuals that Hinder Others over Those that Help. Curr Biol. 2018;28:280-286.e5 pubmed publisher
    ..As the most socially tolerant nonhuman ape [11-17] (but see [18]), bonobos (Pan paniscus) provide a powerful phylogenetic test of whether this trait is ..
  43. Kundi H, Balun A, Cicekcioglu H, Cetin M, Kiziltunç E, Cetin Z, et al. The relation between platelet-to-lymphocyte ratio and Pulmonary Embolism Severity Index in acute pulmonary embolism. Heart Lung. 2015;44:340-3 pubmed publisher
    ..Embolism Severity Index (sPESI), as well as in-hospital mortality in patients with acute pulmonary embolism (APE)...
  44. Palacios González C. The ethics of killing human/great-ape chimeras for their organs: a reply to Shaw et al. Med Health Care Philos. 2016;19:215-25 pubmed publisher
    ..in favour of the procurement of human organs from human/nonhuman-primate chimeras, specifically from great-ape/human chimeras. My main claim is that their arguments fail and are in need of substantial revision...
  45. Laffaye G, Levernier G, Collin J. Determinant factors in climbing ability: Influence of strength, anthropometry, and neuromuscular fatigue. Scand J Med Sci Sports. 2016;26:1151-9 pubmed publisher
    ..characteristics such as height, weight, percentage of body fat and muscle, bi-acromial breath, arm span, and ape index were measured...
  46. Chan M, Hawkes K, Kim P. Evolution of longevity, age at last birth and sexual conflict with grandmothering. J Theor Biol. 2016;393:145-57 pubmed publisher
    ..Similarly to Kim et al. (2014), we find that only two locally stable equilibria exist: one corresponding to great ape-like longevities and the other corresponding to hunter-gatherer longevities...
  47. Mekinian A, Bourrienne M, Carbillon L, Benbara A, Noémie A, Chollet Martin S, et al. Non-conventional antiphospholipid antibodies in patients with clinical obstetrical APS: Prevalence and treatment efficacy in pregnancies. Semin Arthritis Rheum. 2016;46:232-7 pubmed publisher
    ..Patients with clinical obstetrical criteria were tested for anti-phosphatidylethanolamine (aPE) IgG/M, anti-prothrombin/phosphatidylserine (anti-PS/PT) IgG/M, and anti-annexin V IgG...
  48. Peykarjou S, Hoehl S, Pauen S, Rossion B. Rapid Categorization of Human and Ape Faces in 9-Month-Old Infants Revealed by Fast Periodic Visual Stimulation. Sci Rep. 2017;7:12526 pubmed publisher
    This study investigates categorization of human and ape faces in 9-month-olds using a Fast Periodic Visual Stimulation (FPVS) paradigm while measuring EEG...
  49. Ma G, Aznar N, Kalogriopoulos N, Midde K, López Sánchez I, Sato E, et al. Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors. Proc Natl Acad Sci U S A. 2015;112:E2602-10 pubmed publisher
    ..challenged by several studies on a multimodular signal transducer, Gα-Interacting Vesicle associated protein (GIV/Girdin)...
  50. DeLorenzo M, Wu D, Yang K, RUTEL I. RadShield: semiautomated shielding design using a floor plan driven graphical user interface. J Appl Clin Med Phys. 2016;17:509-522 pubmed publisher
    ..A series of geometry-based equations were derived giv-ing the maximum air-kerma rate magnitude and location through a first derivative root finding approach...
  51. Hou S, Harper P, Bardin N, Zhao M. The outcome of ELISA for antiphosphatidylethanolamine antibodies is dependent on the composition of phosphatidylethanolamine. J Immunol Methods. 2017;440:27-34 pubmed publisher
    ..However, the current ELISA-based tests for antiphosphatidylethanolamine (aPE) antibodies remain inconsistent and controversial...
  52. Qian H, Huang J, Yang Y, Yang Y, Li Z, Zhang J. Heart-type Fatty Acid Binding Protein in the Assessment of Acute Pulmonary Embolism. Am J Med Sci. 2016;352:557-562 pubmed publisher
    ..fatty acid binding protein (H-FABP) in the stratification and prognosis of patients with acute pulmonary embolism (APE)...
  53. Aydemir L, Bireller E, Avcı H, Boy Metin Z, Deger K, Unur M, et al. Is Human Oxoguanine Glycosylase 1 Genetic Variant Successful Even on Oral Squamous Cell Carcinoma?. Pathobiology. 2017;84:223-228 pubmed publisher
    ..This study is aimed at investigating the human oxoguanine glycosylase 1 (hOGG1)-Ser326Cys and APE-Asp148Glu polymorphisms of DNA repair genes in OSCC...
  54. Vlčková K, Kreisinger J, Pafčo B, Cížková D, Tagg N, Hehl A, et al. Diversity of Entamoeba spp. in African great apes and humans: an insight from Illumina MiSeq high-throughput sequencing. Int J Parasitol. 2018;48:519-530 pubmed publisher
    ..The findings are important not only for understanding the epidemiology of amoebiasis in humans in rural African localities, but also in the context of wild great ape conservation.
  55. Brun M, Ruault M, Ventura M, Roizes G, De Sario A. Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. Gene. 2003;312:41-50 pubmed
    ..The TPTE gene family was generated before the branching of Old World monkeys from the great ape lineage, by intra- and interchromosome duplications of the ancestral TPTE gene mapping to phylogenetic chromosome ..
  56. Gelernter J, Kranzler H, Sherva R, Almasy L, Koesterer R, Smith A, et al. Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. Mol Psychiatry. 2014;19:41-9 pubmed publisher
    ..17 × 10(-10)) mapped to chromosome 2 at rs1437396, between MTIF2 and CCDC88A, across all of the EA and AA cohorts, with supportive gene expression evidence, and population-specific GWS for ..
  57. Gill C, Bredella M, DeSilva J. Skeletal development of hallucal tarsometatarsal joint curvature and angulation in extant apes and modern humans. J Hum Evol. 2015;88:137-145 pubmed publisher
    ..and angulation in juvenile (n = 68) and adult specimens (n = 102) using computed tomography in humans and extant ape specimens, including Pongo...
  58. Pantó L, Podgorski I, Jánoska M, Márkó O, Harrach B. Taxonomy proposal for Old World monkey adenoviruses: characterisation of several non-human, non-ape primate adenovirus lineages. Arch Virol. 2015;160:3165-77 pubmed publisher
  59. Zhang J, Macfarlane D, Sobko T. Feasibility of a Chest-worn accelerometer for physical activity measurement. J Sci Med Sport. 2016;19:1015-1019 pubmed publisher
    ..78m/s) and fast (2.00, 2.22m/s) walking on a treadmill. Paired t-test, correlations and absolute percentage errors (APE) of accelerometer output (vector magnitude, VM) were computed for the key pairs: Waist-Wrist; and Waist-Chest...
  60. Sasakawa T, Masui K, Kazama T, Iwasaki H. The predictive ability of six pharmacokinetic models of rocuronium developed using a single bolus: evaluation with bolus and continuous infusion regimen. J Anesth. 2016;30:620-7 pubmed publisher
    ..and divergence PE were used to assess inaccuracy, bias, intra-individual variability, and time-related trends in APE and PE values. MDAPE and MDPE values were acceptable only for the Magorian and Kleijn models...
  61. Chintalapati M, Dannemann M, Prüfer K. Using the Neandertal genome to study the evolution of small insertions and deletions in modern humans. BMC Evol Biol. 2017;17:179 pubmed publisher
    ..While the evolution of insertions and deletions have been investigated using ape outgroups, the now available genome of a Neandertal can shed light on the evolution of indels in more recent times...
  62. Wang Q, Ma J, Jiang Z, Wu F, Ping J, Ming L. Diagnostic value of circulating microRNA-27a/b in patients with acute pulmonary embolism. Int Angiol. 2018;37:19-25 pubmed publisher
    ..aims of this study were to evaluate the expression of plasma miR-27a/b in patients with acute pulmonary embolism (APE) and determine the possibility of miR-27a/b as diagnostic biomarkers for APE...
  63. Morrogh Bernard H, Foitova I, Yeen Z, Wilkin P, de Martin R, Rárová L, et al. Self-medication by orang-utans (Pongo pygmaeus) using bioactive properties of Dracaena cantleyi. Sci Rep. 2017;7:16653 pubmed publisher
    ..Here we document self-medication in the only Asian great ape, orang-utans (Pongo pygmaeus), and for the first time, to our knowledge, the external application of an anti-..
  64. Karataş M, Güngör B, İpek G, Çanga Y, Günaydın Z, Onuk T, et al. Association of Serum Cholesterol Levels with Short-term Mortality in Patients with Acute Pulmonary Embolism. Heart Lung Circ. 2016;25:365-70 pubmed publisher
    ..of the present study was to investigate the prognostic value of serum lipid parameters in acute pulmonary embolism (APE)...
  65. Spahr C, Knauf Witzens T, Dähnert L, Enders M, Muller M, Johne R, et al. Detection of HEV-specific antibodies in four non-human primate species, including great apes, from different zoos in Germany. Epidemiol Infect. 2017;:1-6 pubmed publisher
    ..Three ape species and one Old World monkey species were among the seropositive animals: bonobo (Pan paniscus), gorilla (..
  66. Cao K, Li J, Zhao Y, Wang Q, Zeng Q, He S, et al. miR-101 Inhibiting Cell Proliferation, Migration and Invasion in Hepatocellular Carcinoma through Downregulating Girdin. Mol Cells. 2016;39:96-102 pubmed publisher
    ..Here, we aimed to confirm whether Girdin is a target gene of miR-101 and determine the tumor suppressor of miR-101 through Girdin pathway...
  67. Balliano A, Hao F, Njeri C, Balakrishnan L, Hayes J. HMGB1 Stimulates Activity of Polymerase ? on Nucleosome Substrates. Biochemistry. 2017;56:647-656 pubmed publisher
    ..substrates, and, somewhat surprisingly, many of these enzymes, including several DNA glycosylases, AP endonuclease (APE), FEN1 endonuclease, and DNA ligases, have been shown to have activity on DNA substrates within nucleosomes...
  68. Melanson E, Swibas T, Kohrt W, Catenacci V, Creasy S, Plasqui G, et al. Validation of the doubly labeled water method using off-axis integrated cavity output spectroscopy and isotope ratio mass spectrometry. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00241.2017 pubmed publisher
    ..Subjects consumed a dose of 0.25 g H218O (95% APE) and 0.14 g 2H2O (99...
  69. DiGiacomo V, Marivin A, Garcia Marcos M. When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation. Biochemistry. 2017;: pubmed publisher
    ..So far, four proteins present in mammals [GIV (also known as Girdin), DAPLE, CALNUC, and NUCB2] and one protein in Caenorhabditis elegans (GBAS-1) have been described as possessing a ..
  70. Nater A, Mattle Greminger M, Nurcahyo A, Nowak M, de Manuel M, Desai T, et al. Morphometric, Behavioral, and Genomic Evidence for a New Orangutan Species. Curr Biol. 2017;27:3487-3498.e10 pubmed publisher
    ..in our knowledge of fine-scale variation in hominoid morphology, behavior, and genetics, and aspects of great ape taxonomy remain in flux...
  71. Holm T. Abdominoperineal Excision: Technical Challenges in Optimal Surgical and Oncological Outcomes after Abdominoperineal Excision for Rectal Cancer. Clin Colon Rectal Surg. 2017;30:357-367 pubmed publisher
    ..significantly during the recent two decades, but local control and survival after abdominoperineal excision (APE) have not improved to the same degree as that seen after anterior resection (AR)...
  72. Jiang P, Cui S, Ren Y, Mao J, Liu H, Tian Y, et al. Girdin correlated with autophagy in invasive ductal breast carcinomas. Tumori. 2013;99:530-4 pubmed publisher
    Increasing evidence claims that autophagy is essential for breast cancer progression. Girdin was found highly expressed in breast cancers. It has been reported that Girdin attenuates autophagy in HeLa cells...
  73. Mundry R, Oelze V. Who is who matters-The effects of pseudoreplication in stable isotope analyses. Am J Primatol. 2016;78:1017-30 pubmed publisher
    ..We here test the effects of pseudoreplication in stable isotope data of great ape hair by means of simulations...
  74. Kaya S, Kaçar C, Polat B, Colak A, Kaya D, Gurcan I, et al. Association of luteal blood flow with follicular size, serum estrogen and progesterone concentrations, and the inducibility of luteolysis by PGF2? in dairy cows. Theriogenology. 2017;87:167-172 pubmed publisher
    ..The level of LBF was visually graded as + (low; GI), ++ (medium; GII), +++ (high; GIII), and ++++ (very high; GIV). Immediately after the examination of LBFs, a second intramuscular injection of PGF2? was injected...
  75. Zhou H, Yan W, Zhao D, Liang H, Wang G, Ling Z, et al. CT pulmonary angiogram for assessing the treatment outcome of acute pulmonary embolism. Echocardiography. 2017;: pubmed publisher
    To discuss the value of CT pulmonary angiogram (CTPA) for assessing the treatment outcome of acute pulmonary embolism (APE).
  76. Chiatante G, Giannuzzi G, Calabrese F, Eichler E, Ventura M. Centromere Destiny in Dicentric Chromosomes: New Insights from the Evolution of Human Chromosome 2 Ancestral Centromeric Region. Mol Biol Evol. 2017;34:1669-1681 pubmed publisher
    ..resulting in a unique difference in chromosome number between humans (46 chromosomes) and our most closely related ape relatives (48 chromosomes)...
  77. Ghosh P, Rangamani P, Kufareva I. The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block. Cell Cycle. 2017;16:607-612 pubmed publisher
    ..A prototypical member of the GEM family, GIV/Girdin, integrates signals downstream of a myriad of cell surface receptors, e.g...
  78. Zinsser L. Lotus birth, a holistic approach on physiological cord clamping. Women Birth. 2018;31:e73-e76 pubmed publisher
    ..A woman called Clair Lotus Day imitated the holistic approach of PCC from an anthropoid ape in 1974. The chimpanzee did not separate the placenta from the newborn...
  79. Oelze V. Reconstructing temporal variation in great ape and other primate diets: A methodological framework for isotope analyses in hair. Am J Primatol. 2016;78:1004-16 pubmed publisher
    ..The goal of this article is to encourage primatologists to analyze the stable isotope ratios of hair to assess primate feeding ecology. Am. J. Primatol. 78:1004-1016, 2016. © 2015 Wiley Periodicals, Inc. ..
  80. Shimokobe H, Gotoh M, Honda H, Nakamura H, Mitsui Y, Kakuma T, et al. Risk factors for retear of large/massive rotator cuff tears after arthroscopic surgery: an analysis of tearing patterns. J Orthop Surg Res. 2017;12:140 pubmed publisher
    ..group AS), posteosuperior tears (N = 21, group PS), and anteroposterior-extending tears (N = 22, group APE)...
  81. Maziarz M, Garcia Marcos M. Rapid kinetic BRET measurements to monitor G protein activation by GPCR and non-GPCR proteins. Methods Cell Biol. 2017;142:145-157 pubmed publisher
    ..activation by non-GPCR proteins, such as by cytoplasmic guanine nucleotide exchange factors (GEFs) like GIV/Girdin. The BRET assay monitors the release of free G?? from G?-G?? heterotrimers as a readout of G protein activation, ..
  82. Lin C, Ear J, Midde K, López Sánchez I, Aznar N, Garcia Marcos M, et al. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014;25:3654-71 pubmed publisher
    ..We discovered a unifying mechanism that allows GIV/Girdin, a bona fide metastasis-related protein and a guanine-nucleotide exchange factor (GEF) for Gαi, to serve as a ..
  83. Leyme A, Marivin A, Perez Gutierrez L, Nguyen L, Garcia Marcos M. Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin. J Cell Biol. 2015;210:1165-84 pubmed publisher
    ..of the trimeric G protein Gαi by the nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known as Girdin), a metastasis-associated protein...
  84. Aznar N, Patel A, Rohena C, Dunkel Y, Joosen L, Taupin V, et al. AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin. elife. 2016;5: pubmed publisher
    ..How AMPK protects the epithelium remains unknown. Here, we identify GIV/Girdin as a novel effector of AMPK, whose phosphorylation at a single site is both necessary and sufficient for ..
  85. Imanishi J, Kaihotsu K, Yoshikawa S, Nishimori M, Sone N, Honjo T, et al. Acute pulmonary edema in patients with reduced left ventricular ejection fraction is associated with concentric left ventricular geometry. Int J Cardiovasc Imaging. 2018;34:185-192 pubmed publisher
    Although acute pulmonary edema (APE) is common in patients with heart failure (HF) with preserved ejection fraction (EF), its pathogenesis in patients with HF with reduced EF (HFrEF) is not completely understood...
  86. Kwon E, Block M. Implementing the adapted physical education E-learning program into physical education teacher education program. Res Dev Disabil. 2017;69:18-29 pubmed publisher
    ..The purpose of this study was to explore whether an APE e-learning supplement would have an impact on the level of self-efficacy and content knowledge of pre-service ..
  87. Yu L, Sun Y, Li J, Wang Y, Zhu Y, Shi Y, et al. Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism. J Exp Clin Cancer Res. 2017;36:110 pubmed publisher
    ..A short hairpin RNA (shRNA) was used to silence CCDC88A (encoding Girdin), and real-time PCR was performed to determine CCDC88A mRNA expression...
  88. Zhang Y, Li A, Han Y, Yin L, Lin M. Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin. World J Gastroenterol. 2014;20:8229-36 pubmed publisher
    To investigate the effect of Girdin knockdown on the chemosensitivity of colorectal cancer cells to oxaliplatin and the possible mechanisms involved...
  89. Dunkel Y, Diao K, Aznar N, Swanson L, Liu L, Zhu W, et al. Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers. FASEB J. 2016;30:3702-3713 pubmed
    G?-interacting vesicle-associated protein (GIV, aka Girdin) is a guanine exchange factor (GEF) for the trimeric G protein G?i and a bona fide metastasis-related gene that serves as a platform for amplification of tyrosine-based signals ..
  90. Hara A, Hashimura M, Tsutsumi K, Akiya M, Inukai M, Ohta Y, et al. The role of FilGAP, a Rac-specific Rho-GTPase-activating protein, in tumor progression and behavior of astrocytomas. Cancer Med. 2016;5:3412-3425 pubmed publisher
    ..In GIV tumors (GBM: glioblastomas), elongated tumor cells with low FilGAP expression were frequently observed in tumor ..
  91. Wang H, Zhang J, Zhang M, Wei L, Chen H, Li Z. A systematic study of Girdin on cell proliferation, migration and angiogenesis in different breast cancer subtypes. Mol Med Rep. 2017;16:3351-3356 pubmed publisher
    Breast cancer has one of the highest incidences in females worldwide. Girdin is a novel actin‑binding protein, that induces cell migration and angiogenesis...
  92. Maziarz M, Garcia Marcos M. Fluorescence polarization assays to measure interactions between G? subunits of heterotrimeric G proteins and regulatory motifs. Methods Cell Biol. 2017;142:133-143 pubmed publisher
    ..g., GIV/Girdin) or guanine nucleotide dissociation inhibitor (GDI) (e.g., RGS12) activity, respectively...