Gene Symbol: CCDC22
Description: coiled-coil domain containing 22
Alias: CXorf37, JM1, RTSC2, coiled-coil domain-containing protein 22
Species: human
Products:     CCDC22

Top Publications

  1. Harbour M, Breusegem S, Seaman M. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Biochem J. 2012;442:209-20 pubmed publisher
    ..Additionally, overexpression of the Fam21-tail results in cell-spreading defects, implicating the activity of the WASH complex in regulating the mobilization of membrane into the endosome-to-cell surface pathway. ..
  2. Starokadomskyy P, Gluck N, Li H, Chen B, Wallis M, Maine G, et al. CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling. J Clin Invest. 2013;123:2244-56 pubmed publisher
    ..Here we demonstrate that all COMMD proteins bind to CCDC22, a factor recently implicated in X-linked intellectual disability (XLID)...
  3. Ben Shlomo S, Mouhadeb O, Cohen K, Varol C, Gluck N. COMMD10-Guided Phagolysosomal Maturation Promotes Clearance of Staphylococcus aureus in Macrophages. iScience. 2019;14:147-163 pubmed publisher
    ..Finally, expression of COMMD/CCDC22/CCDC93 complex, linked to phagolysosomal maturation, was reduced by COMMD10 deficiency...
  4. Yamashita Y, Nishikawa A, Iwahashi Y, Fujimoto M, Sasaki I, Mishima H, et al. Identification of a novel CCDC22 mutation in a patient with severe Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and aggressive natural killer cell leukemia. Int J Hematol. 2019;: pubmed publisher
    ..developed ANKL, and describe the identification of a novel genetic mutation of coiled-coil domain-containing 22 (CCDC22). He presented with persistent fever, severe pancytopenia, and hepatosplenomegary...
  5. Hunter M, Hesketh G, Benedyk T, Gingras A, Graham S. Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B. J Mol Biol. 2018;430:2153-2163 pubmed publisher
    ..Instead, we identified that VPS33B interacts directly with CCDC22, a member of the CCC complex...
  6. Koral K, Paranjpe S, Bowen W, Mars W, Luo J, Michalopoulos G. Leukocyte-specific protein 1: a novel regulator of hepatocellular proliferation and migration deleted in human hepatocellular carcinoma. Hepatology. 2015;61:537-47 pubmed publisher
    ..To investigate LSP1 function in HCC, short hairpin RNA was utilized to stably knock down LSP1 expression in the JM1 rat hepatoma cell line...
  7. Jo J, Kim W. Carbon material distribution and flux analysis under varying glucose concentrations in hydrogen-producing Clostridium tyrobutyricum JM1. J Biotechnol. 2016;228:103-111 pubmed publisher
    ..The overall flux distribution suggested that C. tyrobutyricum metabolism has a high capacity for the production of butyrate and hydrogen at an initial glucose concentration of 222.4mM, with balanced activities of NADH and ATP. ..
  8. Fedoseienko A, Wijers M, Wolters J, Dekker D, Smit M, Huijkman N, et al. The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Circ Res. 2018;122:1648-1660 pubmed publisher
    COMMD (copper metabolism MURR1 domain)-containing proteins are a part of the CCC (COMMD-CCDC22 [coiled-coil domain containing 22]-CCDC93 [coiled-coil domain containing 93]) complex facilitating endosomal trafficking of cell surface ..
  9. Jia F, Guo S, Shen Y, Gao M, Liu C, Zhou S, et al. Catellatospora vulcania sp. nov. and Catellatospora paridis sp. nov., two novel actinobacteria isolated from volcanic sediment and the rhizosphere of Paris polyphylla. Antonie Van Leeuwenhoek. 2016;109:43-50 pubmed publisher
    Two novel actinobacteria, designated strains NEAU-JM1(T) and NEAU-CL2(T), were isolated from volcanic sediment and the rhizosphere soil of Paris polyphylla, respectively, collected from Jiling and Heilongjiang Province, China...

More Information


  1. Li H, Koo Y, Mao X, Sifuentes Dominguez L, Morris L, Jia D, et al. Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. J Cell Biol. 2015;211:605-17 pubmed publisher
    ..In this study we report that Notch recycling to the cell surface is dependent on the COMMD-CCDC22-CCDC93 (CCC) complex, a recently identified regulator of endosomal trafficking...
  2. Wu Z, Xu Q, Qiu X, Jiao Z, Zhang M, Zhong M. FOXP3 rs3761548 polymorphism is associated with tacrolimus-induced acute nephrotoxicity in renal transplant patients. Eur J Clin Pharmacol. 2017;73:39-47 pubmed publisher
    The purpose of this study was to investigate the potential impact of FOXP3 and CCDC22 gene polymorphisms on efficacy and safety of tacrolimus (TAC) in renal transplant patients...
  3. Park H, You G, Yang K, Kim J, An S, Song J, et al. Role of AKT and ERK pathways in controlling sensitivity to ionizing radiation and adaptive response induced by low-dose radiation in human immune cells. Eur J Cell Biol. 2015;94:653-60 pubmed publisher
    ..However, IM-9 and C1R-sB7 cells were very sensitive to high-dose radiation-induced cell death, whereas Jurkat and JM1 cells showed moderate sensitivity, and THP-1 cells were completely resistant...
  4. Phillips Krawczak C, Singla A, Starokadomskyy P, Deng Z, Osborne D, Li H, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015;26:91-103 pubmed publisher that COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62...
  5. de Oliveira Francisco D, de Paula Andres M, Gueuvoghlanian Silva B, Podgaec S, Fridman C. CCDC22 gene polymorphism is associated with advanced stages of endometriosis in a sample of Brazilian women. J Assist Reprod Genet. 2017;34:939-944 pubmed publisher
    ..the possibility of rs498679 (TLR4 gene), rs1799964 (TNF-? gene), rs3024496 (IL-10 gene), and rs2294021 (CCDC22 gene) polymorphisms being associated with the occurrence of this disease in a sample of Brazilian women...
  6. Mulder J, Wernerus H, Shi T, Ponten F, Hober S, Uhlen M, et al. Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system. Neuroscience. 2007;146:1689-703 pubmed
  7. Nasukawa T, Uchiyama J, Taharaguchi S, Ota S, Ujihara T, Matsuzaki S, et al. Virus purification by CsCl density gradient using general centrifugation. Arch Virol. 2017;162:3523-3528 pubmed publisher
    ..Moreover, adenovirus strain JM1/1 was also successfully purified by this method...
  8. McNally K, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, et al. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nat Cell Biol. 2017;19:1214-1225 pubmed publisher
    ..We establish that retriever associates with the cargo adaptor sorting nexin 17 (SNX17) and couples to CCC (CCDC93, CCDC22, COMMD) and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of α5..
  9. Thanasut K, Fujino K, Taharaguchi M, Taharaguchi S, Shimokawa F, Murakami M, et al. Genome Sequence of Fowl Aviadenovirus A Strain JM1/1, Which Caused Gizzard Erosions in Japan. Genome Announc. 2017;5: pubmed publisher
    This study reports the complete genome sequence of fowl aviadenovirus A strain JM1/1, which caused gizzard erosions in broilers occurring in Japan...
  10. D Amico F, Skarmoutsou E, Lo L, Granata M, Trovato C, Rossi G, et al. Association between rs2294020 in X-linked CCDC22 and susceptibility to autoimmune diseases with focus on systemic lupus erythematosus. Immunol Lett. 2017;181:58-62 pubmed publisher
    ..The X-linked variant rs2294020 is positioned in exon 7 of the CCDC22 gene. The encoded protein functions in the regulation of NF-κB, a master regulator in immune response...
  11. Suttner K, Depner M, Wetzke M, Klopp N, von Mutius E, Illig T, et al. Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk. J Allergy Clin Immunol. 2010;125:1395-9 pubmed publisher
  12. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
    ..Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for ..
  13. Zahradník J, Plačková M, Palyzová A, Maresová H, Kyslíková E, Kyslík P. Draft Genome Sequence of Pantoea agglomerans JM1, a Strain Isolated from Soil Polluted by Industrial Production of Beta-Lactam Antibiotics That Exhibits Valacyclovir-Like Hydrolase Activity. Genome Announc. 2017;5: pubmed publisher
    Strain Pantoea agglomerans JM1 was isolated from the soil of a microbiome that had been exposed to polluting pharmaceuticals. The bacterium exhibited enzymatic activities useful for the biotransformation of beta-lactams...
  14. Kolanczyk M, Krawitz P, Hecht J, Hupalowska A, Miaczynska M, Marschner K, et al. Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome. Eur J Hum Genet. 2015;23:633-8 pubmed publisher
    ..Exome sequencing detected a missense variant (c.1670A>G; p.(Tyr557Cys)) in exon 15 of the CCDC22 gene, which maps to chromosome Xp11.23...
  15. Voineagu I, Huang L, Winden K, Lazaro M, Haan E, Nelson J, et al. CCDC22: a novel candidate gene for syndromic X-linked intellectual disability. Mol Psychiatry. 2012;17:4-7 pubmed publisher