CBX7

Summary

Gene Symbol: CBX7
Description: chromobox 7
Alias: chromobox protein homolog 7
Species: human
Products:     CBX7

Top Publications

  1. Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, et al. Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Int J Cancer. 2014;135:308-18 pubmed publisher
    ..However, recent reports studying the relationship between CBX7 expression and patient survival have differed regarding the tumor cell origins, and the precise role of CBX7 in ..
  2. Maertens G, El Messaoudi Aubert S, Racek T, Stock J, Nicholls J, Rodriguez Niedenführ M, et al. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS ONE. 2009;4:e6380 pubmed publisher
    ..Using tandem affinity purification, we find that CBX7 and CBX8, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two ..
  3. Hinz S, Kempkensteffen C, Christoph F, Krause H, Schrader M, Schostak M, et al. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. Tumour Biol. 2008;29:323-9 pubmed publisher
    ..This study aimed at examining whether mRNA tumor levels of the PCG family members BMI1, SUZ12, RING1, and CBX7 relate to histopathological parameters in urothelial carcinomas of the bladder and whether they may provide ..
  4. Zhang X, Zhang L, Qin W, Yao X, Zheng L, Liu X, et al. Oncogenic role of the chromobox protein CBX7 in gastric cancer. J Exp Clin Cancer Res. 2010;29:114 pubmed publisher
    Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor suppressor locus...
  5. Forzati F, Federico A, Pallante P, Abbate A, Esposito F, Malapelle U, et al. CBX7 is a tumor suppressor in mice and humans. J Clin Invest. 2012;122:612-23 pubmed publisher
    The CBX7 gene encodes a polycomb group protein that is known to be downregulated in many types of human cancers, although the role of this protein in carcinogenesis remains unclear...
  6. Scott C, Gil J, Hernando E, Teruya Feldstein J, Narita M, Martinez D, et al. Role of the chromobox protein CBX7 in lymphomagenesis. Proc Natl Acad Sci U S A. 2007;104:5389-94 pubmed
    Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor ..
  7. Pallante P, Federico A, Berlingieri M, Bianco M, Ferraro A, Forzati F, et al. Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Cancer Res. 2008;68:6770-8 pubmed publisher
    Using gene expression profiling, we found that the CBX7 gene was drastically down-regulated in six thyroid carcinoma cell lines versus control cells...
  8. Dietrich N, Bracken A, Trinh E, Schjerling C, Koseki H, Rappsilber J, et al. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J. 2007;26:1637-48 pubmed
  9. Yap K, Li S, Muñoz Cabello A, Raguz S, Zeng L, Mujtaba S, et al. Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell. 2010;38:662-74 pubmed publisher
    ..Here we report that chromobox 7 (CBX7) within the polycomb repressive complex 1 binds to ANRIL, and both CBX7 and ANRIL are found at elevated levels in ..

More Information

Publications72

  1. Bernstein E, Duncan E, Masui O, Gil J, Heard E, Allis C. Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol. 2006;26:2560-9 pubmed
    ..Here we have investigated the five mouse Polycomb homologs known as Cbx2, Cbx4, Cbx6, Cbx7, and Cbx8...
  2. O Loghlen A, Muñoz Cabello A, Gaspar Maia A, Wu H, Banito A, Kunowska N, et al. MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell. 2012;10:33-46 pubmed publisher
    ..complex 1 (PRC1) components, including five orthologs of the Drosophila Polycomb protein (Cbx2, Cbx4, Cbx6, Cbx7, and Cbx8)...
  3. Gil J, Bernard D, Martinez D, Beach D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol. 2004;6:67-72 pubmed
    ..screen for cDNAs bypassing replicative senescence of normal human prostate epithelial cells (HPrEC), we identified CBX7, a gene that encodes a Polycomb protein, as shown by sequence homology, its interaction with Ring1 and its ..
  4. Vincenz C, Kerppola T. Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. Proc Natl Acad Sci U S A. 2008;105:16572-7 pubmed publisher
    ..We conclude that different CBX proteins are recruited to distinct chromatin regions through nonconserved interactions, expanding the regulatory diversity of polycomb group proteins. ..
  5. Federico A, Pallante P, Bianco M, Ferraro A, Esposito F, Monti M, et al. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Cancer Res. 2009;69:7079-87 pubmed publisher
    Chromobox protein homologue 7 (CBX7) is a chromobox family protein encoding a novel polycomb protein, the expression of which shows a progressive reduction, well related with the malignant grade of the thyroid neoplasias...
  6. Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A, et al. The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients. Eur J Cancer. 2010;46:2304-13 pubmed publisher
    We have previously shown that CBX7 expression is associated with a more malignant phenotype in thyroid cancer. On this basis, we decided to investigate its possible prognostic value in colorectal cancer (CRC)...
  7. Bernard D, Martinez Leal J, Rizzo S, Martinez D, Hudson D, Visakorpi T, et al. CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus. Oncogene. 2005;24:5543-51 pubmed
    ..We recently described CBX7 as a novel PcG protein controlling the growth of normal cells...
  8. Federico A, Sepe R, Cozzolino F, Piccolo C, Iannone C, Iacobucci I, et al. The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration. Biochim Biophys Acta Gene Regul Mech. 2019;1862:509-521 pubmed publisher
    The Chromobox protein homolog 7 (CBX7) belongs to the Polycomb Group (PcG) family, and, as part of the Polycomb repressive complex (PRC1), contributes to maintain transcriptional gene repression...
  9. Pölönen P, Mehtonen J, Lin J, Liuksiala T, Häyrynen S, Teppo S, et al. Hemap: An interactive online resource for characterizing molecular phenotypes across hematologic malignancies. Cancer Res. 2019;: pubmed publisher
    ..and multiple myeloma, linked several polycomb group proteins that could be targeted by small molecules (SFMBT1, CBX7 and EZH1) with CLL, and supported CDK6 as a disease-specific target in AML...
  10. O Loghlen A, Martin N, Krusche B, Pemberton H, Alonso M, Chandler H, et al. The nuclear receptor NR2E1/TLX controls senescence. Oncogene. 2015;34:4069-4077 pubmed publisher
    ..In a screen for transcription factors regulating the expression of the polycomb protein CBX7, we identified NR2E1 as one of its more prominent regulators...
  11. Ding J, Ma L, Zhao J, Xie Y, Zhou J, Li X, et al. An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers. J Transl Med. 2019;17:35 pubmed publisher
    ..Several characteristic genes including CMPK1, CBX7, EIF3L, EIF4A and ZNF395 were indicated to be highly correlated with viremic control...
  12. Peng X, Guan L, Gao B. miRNA-19 promotes non-small-cell lung cancer cell proliferation via inhibiting CBX7 expression. Onco Targets Ther. 2018;11:8865-8874 pubmed publisher
    miR-19 is a critical carcinogenic miRNA that participates in important biological processes of human malignancies. CBX7 plays a key role in lung cancer development and progression...
  13. Rand K, Song C, Dean E, Serie D, Curtin K, Sheng X, et al. A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer Epidemiol Biomarkers Prev. 2016;25:1609-1618 pubmed
    ..SNPs correlated with the index signal in 22q13.1 cluster around the promoter and enhancer regions of CBX7 CONCLUSIONS: We found that reported multiple myeloma susceptibility regions contain risk variants important across ..
  14. Milosevich N, Gignac M, McFarlane J, Simhadri C, Horvath S, Daze K, et al. Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family. ACS Med Chem Lett. 2016;7:139-44 pubmed publisher
    The polycomb paralogs CBX2, CBX4, CBX6, CBX7, and CBX8 are epigenetic readers that rely on "aromatic cage" motifs to engage their partners' methyllysine side chains...
  15. Zhen C, Tatavosian R, Huynh T, Duc H, Das R, Kokotovic M, et al. Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin. elife. 2016;5: pubmed publisher
    ..tracking (SMT) and genetic engineering, we reveal that H3K27me3 contributes significantly to the targeting of Cbx7 and Cbx8 to chromatin, but less to Cbx2, Cbx4, and Cbx6...
  16. Jiang F, Yang X, Meng X, Zhou Z, Chen N. Effect of CBX7 deficiency on the socket healing after tooth extractions. J Bone Miner Metab. 2018;: pubmed publisher
    b>CBX7 is shown to down-regulate the expression of osteopontin (OPN) that is associated with osteoblast function...
  17. Fan J, Lee H, Lee W, Lin C, Hsu C, Hsieh C, et al. Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model. Cell Death Dis. 2018;9:502 pubmed publisher
    ..of adult pluripotent-like olfactory stem cells (APOSCs), which were modulated by an epigenetic repressor of CBX7. APOSCs form a floating sphere, express pluripotency markers Nanog, Oct-4, Sox-2, and SSEA-4 and show alkaline ..
  18. Duan R, Tang G, Du H, Hu Y, Liu P, Xu Y, et al. Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration. Cell Death Differ. 2018;25:1598-1611 pubmed publisher
    ..Especially, knockdown of CBX7 in either embryonic cortical neurons or adult dorsal root ganglion (DRG) neurons enhances their axon growth ability...
  19. Klauke K, Broekhuis M, Weersing E, Dethmers Ausema A, Ritsema M, González M, et al. Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding. Stem Cell Reports. 2015;4:74-89 pubmed publisher
    ..In this study, we experimentally induced distinct types of leukemia in mice by enforced expression of Cbx7. Simultaneous cellular barcoding allowed for thorough analysis of leukemias at the clonal level and revealed high ..
  20. Forzati F, Federico A, Pallante P, Colamaio M, Esposito F, Sepe R, et al. CBX7 gene expression plays a negative role in adipocyte cell growth and differentiation. Biol Open. 2014;3:871-9 pubmed publisher
    We have recently generated knockout mice for the Cbx7 gene, coding for a polycomb group protein that is downregulated in human malignant neoplasias...
  21. Li J, Li Y, Cao Y, Yuan M, Gao Z, Guo X, et al. Polycomb chromobox (Cbx) 7 modulates activation-induced CD4+ T cell apoptosis. Arch Biochem Biophys. 2014;564:184-8 pubmed publisher
    ..Chromobox homolog 7 (Cbx7) is involved in the gene transcription of several cell types...
  22. Meseure D, Vacher S, Alsibai K, Nicolas A, Chemlali W, Caly M, et al. Expression of ANRIL-Polycomb Complexes-CDKN2A/B/ARF Genes in Breast Tumors: Identification of a Two-Gene (EZH2/CBX7) Signature with Independent Prognostic Value. Mol Cancer Res. 2016;14:623-33 pubmed publisher
    ..Expression analysis of ANRIL, EZH2, SUZ12, EED, JARID2, CBX7, BMI1, p16, p15, and p14/ARF genes was evaluated in a large cohort of invasive breast carcinomas (IBC, n = 456) by ..
  23. Xu B, Ji X, Chen X, Yao M, Han X, Chen M, et al. Effect of perfluorooctane sulfonate on pluripotency and differentiation factors in mouse embryoid bodies. Toxicology. 2015;328:160-7 pubmed publisher
    ..Meanwhile, PFOS increased the mRNA and protein levels of polycomb group (PcG) family members (Cbx4, Cbx7, Ezh2)...
  24. Ren C, Morohashi K, Plotnikov A, Jakoncic J, Smith S, Li J, et al. Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain. Chem Biol. 2015;22:161-8 pubmed publisher
    Chromobox homolog 7 (CBX7) plays an important role in gene transcription in a wide array of cellular processes, ranging from stem cell self-renewal and differentiation to tumor progression...
  25. Ni S, Zhao L, Wang X, Wu Z, Hua R, Wan C, et al. CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-?B-miR-21 pathways. J Hematol Oncol. 2018;11:17 pubmed publisher
    b>Chromobox protein homolog 7 (CBX7), a member of the polycomb group (PcG) family of proteins, is involved in the regulation of cell proliferation and cancer progression...
  26. Liu H, Li Z, Li L. The molecular selectivity of UNC3866 inhibitor for Polycomb CBX7 protein from molecular dynamics simulation. Comput Biol Chem. 2018;74:339-346 pubmed publisher
    ..The previous experiments showed that UNC3866 bound the chromodomains of CBX7 strongly, with ?20-fold selectivity over other CBX chromodomains...
  27. Wang W, Lim W, Leong H, Chong F, Lim T, Tan D, et al. An eleven gene molecular signature for extra-capsular spread in oral squamous cell carcinoma serves as a prognosticator of outcome in patients without nodal metastases. Oral Oncol. 2015;51:355-62 pubmed publisher
    ..We identified an 11 gene signature (GGH, MTFR1, CDKN3, PSRC1, SMIM3, CA9, IRX4, CPA3, ZSCAN16, CBX7 and ZFP3) which was robust in segregating tumors by ECS status...
  28. Creppe C, Palau A, Malinverni R, Valero V, Buschbeck M. A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation. PLoS Genet. 2014;10:e1004851 pubmed publisher
    ..We further demonstrate that the exchange of Cbx7 for Cbx8 is required for the effective activation of differentiation genes...
  29. Tatavosian R, Duc H, Huynh T, Fang D, Schmitt B, Shi X, et al. Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nat Commun. 2018;9:2080 pubmed publisher
    ..In contrast, H3.3K27M has no effect on the residence time of Cbx7, but prolongs its search time and decreases its fraction bound to chromatin...
  30. Monaco M, Chiappetta G, Aiello C, Federico A, Sepe R, Russo D, et al. CBX7 Expression in Oncocytic Thyroid Neoplastic Lesions (Hürthle Cell Adenomas and Carcinomas). Eur Thyroid J. 2014;3:211-6 pubmed publisher
    Previous analysis of CBX7 expression in a large number of thyroid adenoma and carcinoma samples revealed a progressive reduction of CBX7 levels that was well related with the malignant grade of thyroid neoplasias...
  31. Hoffmann M, Dehn J, Droop J, Niegisch G, Niedworok C, Szarvas T, et al. Truncated Isoforms of lncRNA ANRIL Are Overexpressed in Bladder Cancer, But Do Not Contribute to Repression of INK4 Tumor Suppressors. Noncoding RNA. 2015;1:266-284 pubmed publisher
    ..performed RNA immunoprecipitation demonstrating interaction between full length or truncated ANRIL and PcG protein CBX7, but not SUZ12 of PRC2...
  32. Forzati F, De Martino M, Esposito F, Sepe R, Pellecchia S, Malapelle U, et al. miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene. BMC Cancer. 2017;17:170 pubmed publisher
    Loss of CBX7 expression has been described in several malignant neoplasias, including human colon and thyroid carcinomas proposing CBX7 as a tumor suppressor gene with a key role in cancer progression...
  33. Zhou Z, Yin Y, Jiang F, Niu Y, Wan S, Chen N, et al. CBX7 deficiency plays a positive role in dentin and alveolar bone development. J Mol Histol. 2016;47:401-11 pubmed publisher
    To clarify the role of CBX7 deficiency in dentin and alveolar bone development, the dental and mandibular phenotypes of homozygous CBX7-knockout (CBX7(-/-)) mice were compared with their wild-type (WT) counterparts at 3 weeks age...
  34. Parfett C, Desaulniers D. A Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In Vitro. Int J Mol Sci. 2017;18: pubmed publisher
    ..mechanisms, 25 epigenetic toxicity pathway components (SET1, MLL1, KDM5, G9A, SUV39H1, SETDB1, EZH2, JMJD3, CBX7, CBX8, BMI, SUZ12, HP1, MPP8, DNMT1, DNMT3A, DNMT3B, TET1, MeCP2, SETDB2, BAZ2A, UHRF1, CTCF, HOTAIR and ANRIL) ..
  35. Rapisarda V, Borghesan M, Miguela V, Encheva V, Snijders A, Lujambio A, et al. Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway. Cell Rep. 2017;18:2480-2493 pubmed publisher
    ..Here, we find that ITGB3 (integrin beta 3 or β3) is regulated by the Polycomb protein CBX7. β3 expression accelerates the onset of senescence in human primary fibroblasts by activating the transforming ..
  36. Wang R, Taylor A, Leal B, Chadwell L, Ilangovan U, Robinson A, et al. Polycomb group targeting through different binding partners of RING1B C-terminal domain. Structure. 2010;18:966-75 pubmed publisher
    ..These results suggest that PcG targeting to different chromatin locations relies, in part, on binding partners of C-RING1B that are diverse in sequence and structure. ..
  37. Santanach A, Blanco E, Jiang H, Molloy K, Sansó M, LaCava J, et al. The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity. Nat Commun. 2017;8:1235 pubmed publisher
    ..In mouse embryonic stem cells (ESCs), CBX6 and CBX7 are the most highly expressed CBX family members...
  38. Bao Z, Xu X, Liu Y, Chao H, Lin C, Li Z, et al. CBX7 negatively regulates migration and invasion in glioma via Wnt/β-catenin pathway inactivation. Oncotarget. 2017;8:39048-39063 pubmed publisher
    b>CBX7, a member of the Polycomb-group proteins, plays a significant role in normal and cancerous tissues and has been defined as a tumor suppressor in thyroid, breast and pancreatic cancers...
  39. Pallante P, Sepe R, Federico A, Forzati F, Bianco M, Fusco A. CBX7 modulates the expression of genes critical for cancer progression. PLoS ONE. 2014;9:e98295 pubmed publisher
    We have previously shown that the expression of CBX7 is drastically decreased in several human carcinomas and that its expression progressively decreases with the appearance of a highly malignant phenotype...
  40. Cacciola N, Sepe R, Forzati F, Federico A, Pellecchia S, Malapelle U, et al. Restoration of CBX7 expression increases the susceptibility of human lung carcinoma cells to irinotecan treatment. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:1179-86 pubmed publisher
    ..Polycomb protein chromobox homolog 7 (CBX7) is involved in several biological processes, including development and cancer progression, indeed the lack of CBX7 ..
  41. Maertens G, El Messaoudi Aubert S, Elderkin S, Hiom K, Peters G. Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J. 2010;29:2553-65 pubmed publisher
    ..Our results point to a novel function for USPs in the regulation and function of Polycomb complexes. ..
  42. Yu T, Wu Y, Hu Q, Zhang J, Nie E, Wu W, et al. CBX7 is a glioma prognostic marker and induces G1/S arrest via the silencing of CCNE1. Oncotarget. 2017;8:26637-26647 pubmed publisher
    Chromobox homolog 7 (CBX7) cooperates with other polycomb group (PcG) proteins to maintain target genes in a silenced state. However, the precise role of CBX7 in tumor progression is still controversial...
  43. Liang Y, Lin H, Chen C, Zeng D. Prognostic values of distinct CBX family members in breast cancer. Oncotarget. 2017;8:92375-92387 pubmed publisher
    ..CBX2 was highly expressed in Basal-like and HER-2 subtypes, while CBX4 and CBX7 expressions were enriched in Luminal A and Luminal B subtypes of BC...
  44. Pickl J, Tichy D, Kuryshev V, Tolstov Y, Falkenstein M, Schüler J, et al. Ago-RIP-Seq identifies Polycomb repressive complex I member CBX7 as a major target of miR-375 in prostate cancer progression. Oncotarget. 2016;7:59589-59603 pubmed publisher
    ..Integration of tissue and gene ontology data prioritized miR-375 targets and identified the tumor suppressor gene CBX7, a member of Polycomb repressive complex 1, as a major miR-375 target...
  45. Kim H, Park J, Won H, Lee J, Kong G. CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/β-catenin pathway. FASEB J. 2015;29:300-13 pubmed publisher
    Polycomb protein chromobox homolog 7 (CBX7) is involved in several biologic processes including stem cell regulation and cancer development, but its roles in breast cancer remain unknown...
  46. Ni S, Wang H, Zhu X, Wan C, Xu J, Lu C, et al. CBX7 suppresses cell proliferation, migration, and invasion through the inhibition of PTEN/Akt signaling in pancreatic cancer. Oncotarget. 2017;8:8010-8021 pubmed publisher
    b>Chromobox protein homolog 7 (CBX7), one of the polycomb group (PcG) proteins, is a transcriptional repressor involved in the regulation of cell proliferation and senescence...
  47. El Messaoudi Aubert S, Nicholls J, Maertens G, Brookes S, Bernstein E, Peters G. Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor. Nat Struct Mol Biol. 2010;17:862-8 pubmed publisher
    ..As well as prompting reassessment of MOV10's role in other settings, our findings suggest that it is directly involved in transcriptional silencing by PcG complexes. ..
  48. Chao T, Zhang Y, Yan X, Yin B, Gong Y, Yuan J, et al. [MiR-9 regulates the expression of CBX7 in human glioma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008;30:268-74 pubmed
    To detect the expression of CBX7 in human glioma and investigate the potential regulatory effect of abnormally expressed microRNAs on CBX7 expression...
  49. Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, et al. Recognition and specificity determinants of the human cbx chromodomains. J Biol Chem. 2011;286:521-9 pubmed publisher
    ..Our structures explain the divergence of peptide binding selectivity in the Pc subfamily and highlight previously unrecognized features of the chromodomain that influence binding and specificity. ..
  50. Garcia E, Marcos Gutierrez C, del Mar Lorente M, Moreno J, Vidal M. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J. 1999;18:3404-18 pubmed
    ..Taken together, these data suggest that RYBP may play a relevant role in PcG function in mammals. ..
  51. Li H, Lai P, Jia J, Song Y, Xia Q, Huang K, et al. RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions. Cell Stem Cell. 2017;20:462-477.e6 pubmed publisher
    ..Together, these results reveal important functions of DDX5 in regulating reprogramming and highlight the importance of a Ddx5-miR125b-Rybp axis in controlling cell fate. ..
  52. Huynh T, Ren X. Producing GST-Cbx7 Fusion Proteins from Escherichia coli. Bio Protoc. 2017;7: pubmed publisher
    This protocol describes the production of GST-Cbx7 fusion proteins from E. coli, originally developed in the recent publication (Zhen et al., 2016)...
  53. Nawaz Z, Patil V, Arora A, Hegde A, Arivazhagan A, Santosh V, et al. Cbx7 is epigenetically silenced in glioblastoma and inhibits cell migration by targeting YAP/TAZ-dependent transcription. Sci Rep. 2016;6:27753 pubmed publisher
    ..In this study, we identified Chromobox homolog 7 (Cbx7), a member of Polycomb Repressive Complex 1 (PRC1), as a downregulated gene in GBM owing to its promoter ..
  54. O Loghlen A, Brookes S, Martin N, Rapisarda V, Peters G, Gil J. CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a). Aging Cell. 2015;14:1113-21 pubmed publisher
    ..The role of PRCs in senescence can be mostly explained by their ability to repress the INK4/ARF locus. CBX7 is one of five mammalian orthologues of Drosophila Polycomb that forms part of PRC1...
  55. Xie D, Shang C, Zhang H, Guo Y, Tong X. Up-regulation of miR-9 target CBX7 to regulate invasion ability of bladder transitional cell carcinoma. Med Sci Monit. 2015;21:225-30 pubmed publisher
    ..miR-9 can regulate the invasion ability of human bladder transitional cell carcinoma cells by down-regulation of CBX7. The expression of miR-9 was detected by quantitative real-time PCR in bladder transitional cell carcinomas (TCC) ..
  56. Junco S, Wang R, Gaipa J, Taylor A, Schirf V, Gearhart M, et al. Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs. Structure. 2013;21:665-71 pubmed publisher
    ..These data show the molecular basis for determining the binding preference for a PCGF homolog, which ultimately helps determine the identity of the larger PRC1-like assembly. ..
  57. Crea F, Di Paolo A, Liu H, Polillo M, Clermont P, Guerrini F, et al. Polycomb genes are associated with response to imatinib in chronic myeloid leukemia. Epigenomics. 2015;7:757-65 pubmed publisher
    ..BMI1, PHC3, CBX6 and CBX7 expression was significantly increased during imatinib treatment...
  58. Sepe R, Formisano U, Federico A, Forzati F, Bastos A, D Angelo D, et al. CBX7 and HMGA1b proteins act in opposite way on the regulation of the SPP1 gene expression. Oncotarget. 2015;6:2680-92 pubmed
    Several recent studies have reported the Polycomb Repressive Complex 1 member CBX7 as a tumor-suppressor gene whose expression progressively decreases in different human carcinomas in relation with tumor grade, malignant stage and poor ..
  59. Guan Z, Gu L, Xing B, Ji J, Gu J, Deng D. [Downregulation of chromobox protein homolog 7 expression in multiple human cancer tissues]. Zhonghua Yu Fang Yi Xue Za Zhi. 2011;45:597-600 pubmed
    To investigate the relationship between chromobox protein homolog 7 (cbx7) expression and the occurrence and development of colorectal carcinoma (CRC), gastric carcinoma (GC) and hepatocarcinoma (HCC) tissues...
  60. Li Q, Wang X, Lu Z, Zhang B, Guan Z, Liu Z, et al. Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus. PLoS ONE. 2010;5:e13732 pubmed publisher
    ..In the present study, we found that upregulating the expression of PRC1 component Cbx7 in gastric cancer cell lines MGC803 and BGC823 led to significantly suppress the expression of genes within the p16-..
  61. Rosenberg M, Blum R, Kesner B, Maier V, Szanto A, Lee J. Denaturing CLIP, dCLIP, Pipeline Identifies Discrete RNA Footprints on Chromatin-Associated Proteins and Reveals that CBX7 Targets 3' UTRs to Regulate mRNA Expression. Cell Syst. 2017;5:368-385.e15 pubmed publisher
    ..step to UV-crosslink RNA immunoprecipitation (dCLIP) and apply dCLIP to mouse and human chromobox homolog 7 (CBX7), an RNA binding subunit of Polycomb repressive complex 1 (PRC1)...
  62. Zheng X, Zhou J, Zhang B, Zhang J, Wilson J, Gu L, et al. Critical evaluation of Cbx7 downregulation in primary colon carcinomas and its clinical significance in Chinese patients. BMC Cancer. 2015;15:145 pubmed publisher
    b>CBX7 is a Polycomb group protein that shows variable expression changes in various cancers that are often contradictive. A mouse knockout experiment has validated the tumor suppressor role in carcinogenesis...
  63. Chubb D, Weinhold N, Broderick P, Chen B, Johnson D, Forsti A, et al. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat Genet. 2013;45:1221-1225 pubmed publisher
    ..67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16))...