Gene Symbol: CBR1
Description: carbonyl reductase 1
Alias: CBR, SDR21C1, hCBR1, carbonyl reductase [NADPH] 1, 15-hydroxyprostaglandin dehydrogenase, NADPH-dependent carbonyl reductase 1, carbonyl reductase (NADPH) 1, prostaglandin 9-ketoreductase, prostaglandin-E(2) 9-reductase, short chain dehydrogenase/reductase family 21C member 1
Species: human
Products:     CBR1

Top Publications

  1. Wermuth B, Platts K, Seidel A, Oesch F. Carbonyl reductase provides the enzymatic basis of quinone detoxication in man. Biochem Pharmacol. 1986;35:1277-82 pubmed
    ..The broad specificity of carbonyl reductase for quinones is in keeping with a role of the enzyme as a general quinone reductase in the catabolism of these compounds. ..
  2. Bohren K, von Wartburg J, Wermuth B. Kinetics of carbonyl reductase from human brain. Biochem J. 1987;244:165-71 pubmed
    ..No significant differences in the kinetic properties of three molecular forms of carbonyl reductase were detectable. ..
  3. Wermuth B. Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. J Biol Chem. 1981;256:1206-13 pubmed
    ..9. The comparison of structural and enzymic features of carbonyl reductase with other monomeric oxidoreductases suggests a close relationship of carbonyl reductase with prostaglandin 9-keto-reductase and xenobiotic ketone reductase. ..
  4. Lakhman S, Chen X, Gonzalez Covarrubias V, Schuetz E, Blanco J. Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor. Mol Pharmacol. 2007;72:734-43 pubmed
    Human carbonyl reductase 1 (CBR1) metabolizes a variety of substrates, including the anticancer doxorubicin and the antipsychotic haloperidol. The transcriptional regulation of CBR1 has been largely unexplored...
  5. Gonzalez Covarrubias V, Kalabus J, Blanco J. Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). Pharm Res. 2008;25:1730-4 pubmed publisher
    Carbonyl reductase 1 (CBR1) reduces the anticancer anthracyclines doxorubicin and daunorubicin into the cardiotoxic metabolites doxorubicinol and daunorubicinol...
  6. Miura T, Nishinaka T, Terada T. Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol Cell Biochem. 2008;315:113-21 pubmed publisher
    ..Human CBR1 (hCBR1) is known as prostaglandin 9-keto reductase and 15-hydroxy dehydrogenase, and regulates the metastasis of cancer ..
  7. Gonzalez Covarrubias V, Zhang J, Kalabus J, Relling M, Blanco J. Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. Drug Metab Dispos. 2009;37:400-7 pubmed publisher
    Carbonyl reductase 1 (CBR1) reduces the anticancer drug doxorubicin into the cardiotoxic metabolite doxorubicinol. We documented the hepatic expression of CBR1 in samples from white and black donors...
  8. Taliani S, Pugliesi I, Da Settimo F. Structural requirements to obtain highly potent and selective 18 kDa Translocator Protein (TSPO) Ligands. Curr Top Med Chem. 2011;11:860-86 pubmed
    ..Indeed, most of these ligands have been designed starting from selective CBR ligands which were structurally modified in order to shift their affinity towards TSPO...
  9. Sheng X, Parmentier J, Tucci J, Pei H, Cortez Toledo O, Dieli Conwright C, et al. Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin. Mol Cancer Res. 2017;15:1704-1713 pubmed publisher
    ..enzymes, aldo-keto reductases (AKR1A1, AKR1B1, AKR1C1, AKR1C2, AKR1C3, and AKR7A2) and carbonyl reductases (CBR1, CBR3), in human adipose tissue, were queried using public databases and directly measured by quantitative PCR (..

More Information

Publications131 found, 100 shown here

  1. Shen L, Chen C, Yang A, Chen Y, Liu Q, Ni J. Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage. J Proteomics. 2015;123:101-13 pubmed publisher
    ..In addition, increased expression level of carbonyl reductase 1 (CBR1) was observed in the hippocampi of 3 × Tg-AD mice...
  2. Derbyshire M, Michaelson L, Parker J, Kelly S, Thacker U, Powers S, et al. Analysis of cytochrome b(5) reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genet Biol. 2015;82:69-84 pubmed publisher
    ..Unlike the model yeast Saccharomyces cerevisiae which possesses only one microsomal CBR, the fully sequenced genome of Z. tritici bears three possible microsomal CBRs...
  3. Ashton N, Allyn G, Porter S, Haussener T, Sebahar P, Looper R, et al. In vitro testing of a first-in-class tri-alkylnorspermidine-biaryl antibiotic in an anti-biofilm silicone coating. Acta Biomater. 2019;: pubmed publisher
    ..concentration (MIC) assay, serial passages, and serial dilution tests against established biofilms grown with a CBR 90 CDC biofilm reactor...
  4. Almada M, Costa L, Fonseca B, Amaral C, Teixeira N, Correia da Silva G. The synthetic cannabinoid WIN-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor. Toxicology. 2017;385:67-73 pubmed publisher
    ..Moreover, these effects were prevented by pre-incubation with a selective cannabinoid receptor 1 (CBR1) antagonist (AM281)...
  5. Pozo Aguilar J, Monroy Martínez V, Díaz D, Barrios Palacios J, Ramos C, Ulloa García A, et al. Evaluation of host and viral factors associated with severe dengue based on the 2009 WHO classification. Parasit Vectors. 2014;7:590 pubmed publisher
    ..The cost-benefit ratio (CBR) was also estimated...
  6. Zhou Z, Wan L, Yang Q, Han Y, Li D, Lu J, et al. Nilotinib reverses ABCB1/P-glycoprotein-mediated multidrug resistance but increases cardiotoxicity of doxorubicin in a MDR xenograft model. Toxicol Lett. 2016;259:124-132 pubmed publisher
    ..In the co-administration group, CBR1 and AKR1A1 protein levels were significantly increased in cardiac tissue, with more severe necrosis and vacuole ..
  7. Stapelfeld C, Maser E. Sex hormones reduce NNK detoxification through inhibition of short-chain dehydrogenases/reductases and aldo-keto reductases in vitro. Chem Biol Interact. 2017;276:167-173 pubmed publisher
    ..by members of the AKR- and the SDR-superfamilies which include AKR1B10, AKR1C1, AKR1C2, AKR1C4, 11?-HSD1 and CBR1. Because some reductases are also involved in steroid metabolism, five different hormones were tested for their ..
  8. Bártíková H, Bousova I, Jedličková P, Lněničková K, Skalova L, Szotakova B. Effect of standardized cranberry extract on the activity and expression of selected biotransformation enzymes in rat liver and intestine. Molecules. 2014;19:14948-60 pubmed publisher
    ..and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT)...
  9. Andrýs R, Zemanová L, Lenčo J, Bílková Z, Wsól V. Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier. Chem Biol Interact. 2015;234:169-77 pubmed publisher
    ..carrier was demonstrated with pure recombinant enzymes (AKR1A1, AKR1B1, AKR1B10, AKR1C1, AKR1C2, AKR1C3, AKR1C4, CBR1 and CBR3) as well as with two model biological samples (cell extract from genetically modified Escherichia coli and ..
  10. Neubrand M, Carey M, Laue T. Influence of Phosphatidylcholine and Calcium on Self-Association and Bile Salt Mixed Micellar Binding of the Natural Bile Pigment, Bilirubin Ditaurate. Biochemistry. 2015;54:6783-95 pubmed publisher
    ..This work should serve as a physicochemical template for studies with other conjugated bilirubins, including bilirubin diglucuronoside (BDG), the principal bilirubin conjugate (cBR) in human bile.
  11. Vujić N, Korbelius M, Leopold C, Duta Mare M, Rainer S, Schlager S, et al. Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice. Oncotarget. 2017;8:33122-33136 pubmed publisher
    ..2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid and potent activator of cannabinoid receptors (CBR) 1 and 2...
  12. Stapelfeld C, Neumann K, Maser E. Different inhibitory potential of sex hormones on NNK detoxification in vitro: A possible explanation for gender-specific lung cancer risk. Cancer Lett. 2017;405:120-126 pubmed publisher
    ..It is mediated by different carbonyl reductases of the SDR (CBR1 and 11βHSD1) and AKR (AKR1B10, AKR1C1, AKR1C2 and AKR1C4) superfamilies...
  13. Kang Y, Yau T, Park J, Lim H, Lee T, Obi S, et al. Randomized phase II study of axitinib versus placebo plus best supportive care in second-line treatment of advanced hepatocellular carcinoma. Ann Oncol. 2015;26:2457-63 pubmed publisher
    ..end point analyses [progression-free survival (PFS), time to tumour progression (TTP), and clinical benefit rate (CBR)], and were retained among Asian patients in the prespecified subgroup analyses...
  14. Aguilera Portillo G, Rangel López E, Villeda Hernandez J, Chavarria A, Castellanos P, Elmazoglu Z, et al. The Pharmacological Inhibition of Fatty Acid Amide Hydrolase Prevents Excitotoxic Damage in the Rat Striatum: Possible Involvement of CB1 Receptors Regulation. Mol Neurobiol. 2019;56:844-856 pubmed publisher
    ..induced by QUIN (1 μL intrastriatal, 240 nmol/μL), while modified the early localization patterns of CBr1 (CB1) and NMDAr subunit 1 (NR1)...
  15. Aydin I, Villalonga Planells R, Greune L, Bronnimann M, Calton C, Becker M, et al. A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry. PLoS Pathog. 2017;13:e1006308 pubmed publisher
    ..Analyzing various HPV16 L2 truncation-mutants revealed a central chromosome-binding region (CBR) of 147 amino acids that confers binding to mitotic chromosomes...
  16. Al Thani M, Sadoun E, Al Thani A, Khalifa S, Sayegh S, BADAWI A. Change in the structures, dynamics and disease-related mortality rates of the population of Qatari nationals: 2007-2011. J Epidemiol Glob Health. 2014;4:277-87 pubmed publisher
    ..Factors reflecting population dynamics such as crude death (CDR), crude birth (CBR), total fertility (TFR) and infant mortality (IMR) rates were also calculated...
  17. Pirone A, Lenzi C, Briganti A, Abbate F, Levanti M, Abramo F, et al. Spatial distribution of cannabinoid receptor 1 and fatty acid amide hydrolase in the cat ovary and oviduct. Acta Histochem. 2017;119:417-422 pubmed publisher
    ..Luteal cells were immunopositive for both CB1R and FAAH. Because CBR1 in oviduct was found only in ciliated cells, it might represent a specific marker at least in cats...
  18. Varatharajan S, Panetta J, Abraham A, Karathedath S, Mohanan E, Lakshmi K, et al. Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia. Cancer Chemother Pharmacol. 2016;78:1051-1058 pubmed
    ..Genetic variants in ABCB1, ABCG2, CBR1, and CBR3 genes as well as RNA expression of CBR1, ABCB1, and ABCG2 were compared with Dnr PK parameters...
  19. Zhang L, Kolaj M, Renaud L. Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons. Neuroscience. 2016;322:308-19 pubmed publisher
    ..revealed a reversible suppression during bath applications of membrane permeable cannabinoid receptor (CBR) blockers rimonabant, AM630 or SR144528 suggesting the presence of both CB1Rs and CB2Rs...
  20. Larson B, Van M, Nakayama T, Engebrecht J. Plasticity in the Meiotic Epigenetic Landscape of Sex Chromosomes in Caenorhabditis Species. Genetics. 2016;203:1641-58 pubmed publisher
    ..Further, both histone H3 lysine 9 di- and trimethylation were reduced in Cbr-met-2 mutant germ lines, suggesting that in contrast to C...
  21. Hung C, Zingarelli S, Nadeau L, Biffinger J, Drake C, Crouch A, et al. Carbon Catabolite Repression and Impranil Polyurethane Degradation in Pseudomonas protegens Strain Pf-5. Appl Environ Microbiol. 2016;82:6080-6090 pubmed
    ..Bioinformatic analysis showed that putative Cbr/Hfq/Crc-mediated regulatory elements were present in the intergenic sequences upstream of both pueA and pueB genes...
  22. Hui E, Ma B, Loong H, Mo F, Li L, King A, et al. Efficacy, Safety, and Pharmacokinetics of Axitinib in Nasopharyngeal Carcinoma: A Preclinical and Phase II Correlative Study. Clin Cancer Res. 2018;24:1030-1037 pubmed publisher
    ..Axitinib was started at 5 mg twice daily in continuous 4-week cycles. Primary endpoint was clinical benefit rate (CBR), defined as the percentage of patients achieving complete response, partial response, or stable disease by RECIST ..
  23. Chia C, Carlson O, Liu D, González Mariscal I, Santa Cruz Calvo S, Egan J. Incretin secretion in humans is under the influence of cannabinoid receptors. Am J Physiol Endocrinol Metab. 2017;313:E359-E366 pubmed publisher
    ..recruited 20 healthy men to evaluate GIP and GLP-1 responses during OGTT after administering placebo or nabilone (CBR agonist) in a randomized, double-blind, crossover fashion...
  24. Beadell A, Haag E. Evolutionary Dynamics of GLD-1-mRNA complexes in Caenorhabditis nematodes. Genome Biol Evol. 2014;7:314-35 pubmed publisher
    ..We also detected several hundred Cbr-GLD-1 targets whose homologs have not been reported to be associated with C...
  25. Sagheb K, Schiegnitz E, Moergel M, Walter C, Al Nawas B, Wagner W. Clinical outcome of alveolar ridge augmentation with individualized CAD-CAM-produced titanium mesh. Int J Implant Dent. 2017;3:36 pubmed publisher
    ..In 17 patients, 21 different regions were augmented with an individualized CAD-CAM-produced TM (Yxoss CBR®, Filderstadt, Germany)...
  26. Nithipatikom K, Isbell M, Endsley M, Woodliff J, Campbell W. Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells. Prostaglandins Other Lipid Mediat. 2011;94:34-43 pubmed publisher
    ..manner; however, SR141716A, SR144528 and pertussis toxin did not block the NE-inhibited proliferation, suggesting a CBR-independent mechanism of NE...
  27. Bukum N, Novotna E, Morell A, Hofman J, Wsol V. Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3. Chem Biol Interact. 2019;302:101-107 pubmed publisher
    ..carbonyl-reducing enzymes: AKR1A1, AKR1B1, AKR1B10, AKR1C3, and AKR7A2 from the aldo-keto reductase superfamily and CBR1 from the short-chain dehydrogenase/reductase superfamily, all of which participate in the metabolism of ..
  28. Chana R, Mansouri R, Jack C, Edwards M, Singh R, Keller C, et al. The suitability of an uncemented hydroxyapatite coated (HAC) hip hemiarthroplasty stem for intra-capsular femoral neck fractures in osteoporotic elderly patients: the Metaphyseal-Diaphyseal Index, a solution to preventing intra-operative periprosthet. J Orthop Surg Res. 2011;6:59 pubmed publisher
    ..As a control (gold standard), Yeung et al's Canal Bone Ratio (CBR) score was also calculated...
  29. Nguyen L, Myslivečková Z, Szotakova B, Spičáková A, Lněničková K, Ambroz M, et al. The inhibitory effects of ?-caryophyllene, ?-caryophyllene oxide and ?-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro. Chem Biol Interact. 2017;278:123-128 pubmed publisher
    ..other hand, none of the tested sesquiterpenes significantly affected the activities of carbonyl-reducing enzymes (CBR1, AKRs, NQO1) or conjugation enzymes (UGTs, GSTs, SULTs, COMT)...
  30. Van Schil K, Karlstetter M, Aslanidis A, Dannhausen K, Azam M, Qamar R, et al. Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7. Sci Rep. 2016;6:21307 pubmed publisher
    ..Three variants are located in a promoter CBR termed CBR1, while the fourth is located more downstream in CBR2...
  31. Dell Ova M, De Maio E, Guiu S, Roca L, Dalenc F, Durigova A, et al. Tumour biology, metastatic sites and taxanes sensitivity as determinants of eribulin mesylate efficacy in breast cancer: results from the ERIBEX retrospective, international, multicenter study. BMC Cancer. 2015;15:659 pubmed publisher
    ..The objective response rate was 25.2 % (95 %CI: 20-31) with a 36.1 % clinical benefit rate (CBR). Median time to progression (TTP) and overall survival were 3.97 (95 %CI: 3.25-4.3) and 11.2 (95 %CI: 9.3-12...
  32. Platt A, Xia Z, Liu Y, Chen G, Lazarus P. Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases. Pharmacogenet Genomics. 2016;26:370-80 pubmed publisher
    ..were identified in incubations of EXE with pooled human liver cytosol or recombinant protein for AKR1Cs and CBR1. Kinetic parameters characterizing EXE reduction were measured for purified wild-type enzymes, and nonsynonymous ..
  33. Kimura K, Iwamoto M, Tanaka S, Yamamoto D, Yoshidome K, Ogura H, et al. A phase II, multicenter, single-arm trial of eribulin as first- or second-line chemotherapy for HER2-negative advanced or metastatic breast cancer: evaluation of efficacy, safety, and patient-reported outcomes. Cancer Chemother Pharmacol. 2018;81:923-933 pubmed publisher
    ..and the secondary endpoints included the clinical benefit rate (ORR + stable disease for 6 months; CBR), progression-free survival (PFS), overall survival (OS), duration of response (DOR), safety, and health-related ..
  34. Lemieux N, Malfoy B, Forrest G. Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells. Genomics. 1993;15:169-72 pubmed
    Human carbonyl reductase (CBR) belongs to a group of NADPH-dependent enzymes called aldo-keto reductases...
  35. Balcz B, Kirchner L, Cairns N, Fountoulakis M, Lubec G. Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease. J Neural Transm Suppl. 2001;:193-201 pubmed
    ..catalyzed by aldehyde dehydrogenase (ALDH), or by reduction to their corresponding alcohols by carbonyl reductase (CBR) and/or alcohol dehydrogenase (ADH)...
  36. Bateman R, Rauh D, Tavshanjian B, Shokat K. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. J Biol Chem. 2008;283:35756-62 pubmed publisher
    Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-..
  37. Li W, Wang T, Bian L, Zhang S, Zhang H, Zhou J, et al. [Clinical efficacy and safety of trastuzumab plus capecitabine as first-line therapy for HER-2 positive metastatic breast cancer]. Zhonghua Yi Xue Za Zhi. 2015;95:2796-8 pubmed
    ..6 months. The objective response rate (ORR) was 31.6%. Clinical benefit rate (CBR) was 65.8%. The most serious adverse event was leucopenia in one patient...
  38. Luruli R, Netshandama V, Francis J. An improved model for provision of rural community-based health rehabilitation services in Vhembe District, Limpopo Province of South Africa. Afr J Prim Health Care Fam Med. 2016;8:e1-e10 pubmed publisher
    In 1991, Riakona Community Rehabilitation Programme initiated community-based rehabilitation (CBR) in the Vhembe District of Limpopo Province. Subsequently, the South African government adopted the programme...
  39. Kouyoumdjian P, Dhenin A, Dupeyron A, Coulomb R, Asencio G. Periprosthetic fracture in the elderly with anatomic modular cementless hemiarthroplasty. Orthop Traumatol Surg Res. 2016;102:701-5 pubmed publisher
    ..of periprosthetic fractures (PPFs) and, 2) the influence of anatomic factors, including the Cortical Bone Ratio (CBR) (the relation between the endosteal and external diameter of the femoral diaphysis 10cm below the lesser ..
  40. Xu F, Liu X, Chen W, Zhou C, Cao B. Ontology-Based Method for Fault Diagnosis of Loaders. Sensors (Basel). 2018;18: pubmed publisher
    ..achieve the integrating, sharing and reusing of fault diagnosis knowledge for loaders; (2) combined with ontology, CBR (case-based reasoning) is introduced to realize effective and accurate fault diagnoses following four steps (..
  41. Colombe L, Vindrios A, Michelet J, Bernard B. Prostaglandin metabolism in human hair follicle. Exp Dermatol. 2007;16:762-9 pubmed
    ..e. carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 (mPGES-1) and microsomal prostaglandin E synthase-2 (mPGES-2), cytosolic ..
  42. Geetha K, Umadevi M, Sathe G, Vanelle P, Terme T, Khoumeri O. Surface Enhanced Raman Spectroscopic investigations of 2-bromo-3-methylamino-1,4-naphthoquinone on silver nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc. 2015;136 Pt C:1967-73 pubmed publisher
    ..The observed intense CO stretching, CBr stretching and NH2 vibration suggests that the BMANQ molecule may be adsorbed in a 'stand-on' orientation to the ..
  43. Drew R, Blaha C, Herr M, Stocker S, Sinoway L. Healthy older humans exhibit augmented carotid-cardiac baroreflex sensitivity with aspirin during muscle mechanoreflex and metaboreflex activation. Am J Physiol Heart Circ Physiol. 2015;309:H1361-9 pubmed publisher
    Low-dose aspirin inhibits thromboxane production and augments the sensitivity of carotid baroreflex (CBR) control of heart rate (HR) during concurrent muscle mechanoreflex and metaboreflex activation in healthy young humans...
  44. Barber S, Hickson D, Kawachi I, Subramanian S, Earls F. Double-jeopardy: The joint impact of neighborhood disadvantage and low social cohesion on cumulative risk of disease among African American men and women in the Jackson Heart Study. Soc Sci Med. 2016;153:107-15 pubmed publisher
    ..which social cohesion modifies the relationship between neighborhood disadvantage and cumulative biological risk (CBR)-a measure of accumulated risk across multiple physiological systems...
  45. Ferraro D, Goldstein D, O Connell R, Zalcberg J, Sjoquist K, Tebbutt N, et al. TACTIC: a multicentre, open-label, single-arm phase II trial of panitumumab, cisplatin, and gemcitabine in biliary tract cancer. Cancer Chemother Pharmacol. 2016;78:361-7 pubmed publisher
    ..The primary endpoint was the clinical benefit rate (CBR) at 12 weeks (complete response, partial response, or stable disease)...
  46. Porta A, Marchi A, Bari V, De Maria B, Esler M, Lambert E, et al. Assessing the strength of cardiac and sympathetic baroreflex controls via transfer entropy during orthostatic challenge. Philos Trans A Math Phys Eng Sci. 2017;375: pubmed publisher
    ..Both cardiac BR (cBR) and sympathetic BR (sBR) were characterized via BR sequence approaches from spontaneous fluctuations of heart ..
  47. Frogley B, Hill A. A complete set of pnictocarbynes: [M([triple bond, length as m-dash]CAPh2)(CO)2(Tp*)] (M = Mo, W; A = N, P, As, Sb, Bi; Tp* = hydrotris(dimethylpyrazolyl)-borate). Chem Commun (Camb). 2018;54:2126-2129 pubmed publisher
    ..The heavier analogues (A ≠ N) result from successive treatment of [M([triple bond, length as m-dash]CBr)(CO)2(Tp*)] with nBuLi and ClAPPh2 (A = P, Sb, Bi) or BrAsPh2 and ..
  48. Lal S, Sandanaraj E, Wong Z, Ang P, Wong N, Lee E, et al. CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. Cancer Sci. 2008;99:2045-54 pubmed publisher
    The present study aimed to identify polymorphic genes encoding carbonyl reductases (CBR1, CBR3) and investigate their influence on doxorubicin disposition in Asian breast cancer patients (n = 62)...
  49. Murakami A, Yakabe K, Yoshidomi K, Sueoka K, Nawata S, Yokoyama Y, et al. Decreased carbonyl reductase 1 expression promotes malignant behaviours by induction of epithelial mesenchymal transition and its clinical significance. Cancer Lett. 2012;323:69-76 pubmed publisher
    Human carbonyl reductase 1 (CBR1) is an enzyme that catalyse the reduction of many compounds by using NADPH-dependent oxydoreductase activity...
  50. Hwang B, Kim M. Implicit learning of a speed-contingent target feature. Psychon Bull Rev. 2016;23:803-8 pubmed publisher
    ..We called this new type of cueing, "cueing-by-response" (CBR). We investigated whether CBR could be learned implicitly...
  51. Penttilä P, Donskov F, Rautiola J, Peltola K, Laukka M, Bono P. Everolimus-induced pneumonitis associates with favourable outcome in patients with metastatic renal cell carcinoma. Eur J Cancer. 2017;81:9-16 pubmed publisher
    ..001), progression-free survival (PFS) (5.5 versus 3.2 months; P = 0.002) and clinical benefit rate (CBR) 57.1% versus 24.1% (P = 0.003)...
  52. van Diessen E, van der Maas F, Cabral V, Otte W. Community-based rehabilitation offers cost-effective epilepsy treatment in rural Guinea-Bissau. Epilepsy Behav. 2018;79:23-25 pubmed publisher
    ..We used a community-based rehabilitation (CBR) service for the detection, monitoring, and treatment of epilepsy...
  53. Buckley P, Belec J, Levy J. Environmental Resource Management in Borderlands: Evolution from Competing Interests to Common Aversions. Int J Environ Res Public Health. 2015;12:7541-57 pubmed publisher
    ..border in a part of the Fraser Lowland, we look for evidence of the emergence of an active and sustainable CBR to address local trans-border resource management issues...
  54. Chong L, Twa D, Mottok A, Ben Neriah S, Woolcock B, Zhao Y, et al. Comprehensive characterization of programmed death ligand structural rearrangements in B-cell non-Hodgkin lymphomas. Blood. 2016;128:1206-13 pubmed publisher
    ..of the precise chromosomal breakpoints reveals 2 distinct cluster breakpoint regions (CBRs) within either CD274 (CBR1) or PDCD1LG2 (CBR2)...
  55. Malátková P, Kanavi M, Nobilis M, Wsol V. In vitro metabolism of fenofibric acid by carbonyl reducing enzymes. Chem Biol Interact. 2016;258:153-8 pubmed publisher
    ..Of nine carbonyl-reducing enzymes (CREs) tested, CBR1 exhibited the greatest activity for fenofibric acid reduction (CLint = 85.975 ?l/mg protein/min)...
  56. Kim D, Lee H, Oh K, Ki A, Protzman R, Kim D, et al. Exploration of the metal coordination region of concanavalin A for its interaction with human norovirus. Biomaterials. 2017;128:33-43 pubmed publisher
    ..The mutated carbohydrate binding region of Con A (mCon ACBR) does not affect binding affinity significantly, indicating that MCR of Con A is a major region of ..
  57. Zhang T, Gillies M, Madigan M, Shen W, Du J, Grünert U, et al. Disruption of De Novo Serine Synthesis in Müller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage. Mol Neurobiol. 2018;55:7025-7037 pubmed publisher
    ..In this study, we inhibited de novo serine synthesis using CBR-5884, a specific inhibitor of phosphoglycerate dehydrogenase (PHGDH, a rate limiting enzyme in de novo serine ..
  58. Carletti F, Gambino G, Rizzo V, Ferraro G, Sardo P. Cannabinoid and nitric oxide signaling interplay in the modulation of hippocampal hyperexcitability: Study on electrophysiological and behavioral models of temporal lobe epilepsy in the rat. Neuroscience. 2015;303:149-59 pubmed publisher
    ..In the light of this, our findings suggest a putative antagonism between CBr-activated pathway and NO signaling in the context of neuronal hyperexcitability and contribute to elucidate ..
  59. Chase K, Feiner B, Rosen C, Gavin D, Sharma R. Characterization of peripheral cannabinoid receptor expression and clinical correlates in schizophrenia. Psychiatry Res. 2016;245:346-353 pubmed publisher
    ..In the brain, cannabinoid receptors (CBR) directly modulate neurotransmitter systems...
  60. Pizzuti L, Marchetti P, Natoli C, Gamucci T, Santini D, Scinto A, et al. Fasting glucose and body mass index as predictors of activity in breast cancer patients treated with everolimus-exemestane: The EverExt study. Sci Rep. 2017;7:10597 pubmed publisher
    ..Best overall response (BR) and clinical benefit rate (CBR) were assessed across subgroups defined upon fasting glucose (FG) and body mass index (BMI)...
  61. Cao H, Miao C, Yan L, Tang P, Zhang L, Sun L. Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients. J Transl Med. 2017;15:235 pubmed publisher
    ..OS and RFS, respectively), and four anthracycline-metabolic gene SNPs (ABCC1 rs3743527, rs212091, and rs212090 and CBR1 rs9024) were significantly associated with chemotherapy-related toxicities...
  62. Gambardella C, Nichino D, Iacometti C, Ferrando S, Falugi C, Faimali M. Long term exposure to low dose neurotoxic pesticides affects hatching, viability and cholinesterase activity of Artemia sp. Aquat Toxicol. 2018;196:79-89 pubmed publisher
    ..of several neuroactive pesticides (chlorpyrifos (CLP), chlorpyrifos oxon (CLP ox), diazinon (DZN), carbaryl (CBR)) following exposure to far below than lethal doses...
  63. Fernández Rivero M, del Pozo J, Valentín A, de Diego A, Peman J, Cantón E. Activity of Amphotericin B and Anidulafungin Combined with Rifampicin, Clarithromycin, Ethylenediaminetetraacetic Acid, N-Acetylcysteine, and Farnesol against Candida tropicalis Biofilms. J Fungi (Basel). 2017;3: pubmed publisher
    ..Biofilm growth kinetics were performed in a CDC Biofilm Reactor (CBR)...
  64. Krook M, Ghosh D, Stromberg R, Carlquist M, Jornvall H. Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase. Proc Natl Acad Sci U S A. 1993;90:502-6 pubmed
  65. Staab C, Hartmanová T, El Hawari Y, Ebert B, Kisiela M, Wsol V, et al. Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3. Chem Biol Interact. 2011;191:95-103 pubmed publisher
    Human carbonyl reductases 1 and 3 (CBR1 and CBR3) are monomeric NADPH-dependent enzymes of the short-chain dehydrogenase/reductase superfamily...
  66. Ewald A, Becker S, Heinrich A, Banaschewski T, Poustka L, Bokde A, et al. The role of the cannabinoid receptor in adolescents' processing of facial expressions. Eur J Neurosci. 2016;43:98-105 pubmed publisher
    ..in the striatum to happy faces in adults, yet, for adolescents, it is not clear whether an association between CBR1 and face processing exists...
  67. Hensley M, Patel S, von Mehren M, Ganjoo K, Jones R, Staddon A, et al. Efficacy and safety of trabectedin or dacarbazine in patients with advanced uterine leiomyosarcoma after failure of anthracycline-based chemotherapy: Subgroup analysis of a phase 3, randomized clinical trial. Gynecol Oncol. 2017;146:531-537 pubmed publisher
    ..secondary endpoints were progression-free survival (PFS), objective response rate (ORR), clinical benefit rate (CBR: complete responses+partial responses+stable disease [SD] for at least 18weeks), duration of response (DOR), and ..
  68. Morgan R, Beck K, Nixon M, Homer N, Crawford A, Melchers D, et al. Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity. Sci Rep. 2017;7:10633 pubmed publisher
    Carbonyl Reductase 1 (CBR1) is a ubiquitously expressed cytosolic enzyme important in exogenous drug metabolism but the physiological function of which is unknown. Here, we describe a role for CBR1 in metabolism of glucocorticoids...
  69. Chen C, Siegel D, Gutierrez M, Jacoby M, Hofmeister C, Gabrail N, et al. Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom's macroglobulinemia. Blood. 2017;: pubmed publisher
    ..agent selinexor showed modest efficacy with an objective response rate (ORR) of 4% and clinical benefit rate (CBR) of 21%...
  70. Takami M, Herrera R, Petruzzelli L. Mac-1-dependent tyrosine phosphorylation during neutrophil adhesion. Am J Physiol Cell Physiol. 2001;280:C1045-56 pubmed
    ..was inducible when Mac-1 was activated by phorbol 12-myristate 13-acetate, the beta(2)-specific activating antibody CBR LFA-1/2, or interleukin-8 (77 amino acids)...
  71. Hlaváč V, Brynychová V, Václavíková R, Ehrlichová M, Vrána D, Pecha V, et al. The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients. Medicine (Baltimore). 2014;93:e255 pubmed publisher
    ..Protein products of AKR1C1, AKR1C2, AKR7A3, CYP3A4, and carbonyl reductase (CBR1) were found in tumors and those of AKR1C1, AKR7A3, and CBR1 correlated with their transcript levels...
  72. Alshogran O, Urquhart B, Nolin T. Downregulation of Hepatic Carbonyl Reductase Type 1 in End-Stage Renal Disease. Drug Metab Lett. 2015;9:111-8 pubmed
    ..functional expression of selective hepatic reductases in ESRD livers, which may partially explain altered pharmacokinetics of CBR1 drug substrates in ESRD. Future studies with larger sample size are warranted to confirm these findings.
  73. Inoue K, Saito T, Okubo K, Kimizuka K, Yamada H, Sakurai T, et al. Phase II clinical study of eribulin monotherapy in Japanese patients with metastatic breast cancer who had well-defined taxane resistance. Breast Cancer Res Treat. 2016;157:295-305 pubmed publisher
    ..The primary endpoint was the clinical benefit rate (CBR) [complete response (CR), partial response (PR), and long-term stable disease (LSD) ?24 weeks]...
  74. Hua W, Zhang H, Ryu S, Yang X, Di L. Human Tissue Distribution of Carbonyl Reductase 1 Using Proteomic Approach With Liquid Chromatography-Tandem Mass Spectrometry. J Pharm Sci. 2017;106:1405-1411 pubmed publisher
    Human tissue distribution of carbonyl reductase 1 (CBR1) is quite controversial in the literature...
  75. Norberg B, Kleppe L, Andersson E, Thorsen A, Rosenlund G, Hamre K. Effects of dietary arachidonic acid on the reproductive physiology of female Atlantic cod (Gadus morhua L.). Gen Comp Endocrinol. 2017;250:21-35 pubmed publisher
    ..acute regulatory protein (star), P450aromatase (cyp19a1a) and 20?-hydroxy steroid dehydrogenase (20bhsd/cbr1) were monitored every month in fish fed the experimental diets and related to oocyte stage...
  76. Osborne C, Challagalla J, Eisenbeis C, Holmes F, Neubauer M, Koutrelakos N, et al. Ixabepilone and Carboplatin for Hormone Receptor Positive/HER2-neu Negative and Triple Negative Metastatic Breast Cancer. Clin Breast Cancer. 2018;18:e89-e95 pubmed publisher
    ..The secondary objectives included progression-free survival (PFS), clinical benefit rate (CBR), overall survival (OS), and toxicity...
  77. Gilmore B, MacLachlan M, McVeigh J, McClean C, Carr S, Duttine A, et al. A study of human resource competencies required to implement community rehabilitation in less resourced settings. Hum Resour Health. 2017;15:70 pubmed publisher
    ..The community-based rehabilitation (CBR) guidelines, with sufficient and sustained support, can assist in providing access to rehabilitation services, ..
  78. Ramshini E, Sepehri G, Ahmadi Zeidabadi M, Arjmand S, Khaksari M, Shabani M. Contribution of CB1Rs in anxiety-related behaviors but not locomotor deficits induced by methamphetamine. Neurosci Lett. 2018;665:240-245 pubmed publisher
    ..The behavioral effects of systemic CBR agonist (3mg/kg/day WIN55,212-2) and antagonist (10mg/kg SR141716A) treatment on METH-induced motor deficits in ..
  79. Mahe B, Masclaux C, Rauscher L, Enard C, Expert D. Differential expression of two siderophore-dependent iron-acquisition pathways in Erwinia chrysanthemi 3937: characterization of a novel ferrisiderophore permease of the ABC transporter family. Mol Microbiol. 1995;18:33-43 pubmed
    ..study reported that global regulation by iron in this strain was mediated at the transcriptional level via the cbr locus which, when inactivated by insertional mutation, prevents the chrysobactin system from being tightly ..
  80. Tinguely J, Wermuth B. Identification of the reactive cysteine residue (Cys227) in human carbonyl reductase. Eur J Biochem. 1999;260:9-14 pubmed
    ..Conversely, the binding of free glutathione to both mutants was reduced. Our findings indicate that Cys227 is the reactive residue and suggest that it is involved in the binding of both substrate and glutathione. ..
  81. Finckh C, Atalla A, Nagel G, Stinner B, Maser E. Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung. Chem Biol Interact. 2001;130-132:761-73 pubmed
  82. Yoon H, Lee S. Establishing a laboratory model of dental unit waterlines bacterial biofilms using a CDC biofilm reactor. Biofouling. 2017;:1-10 pubmed publisher
    ..a laboratory model to reproduce dental unit waterline (DUWL) biofilms was developed using a CDC biofilm reactor (CBR)...
  83. Wirth H, Wermuth B. Immunohistochemical localization of carbonyl reductase in human tissues. J Histochem Cytochem. 1992;40:1857-63 pubmed
    ..The results are in agreement with a housekeeping function of carbonyl reductase in the elimination of reactive carbonyl compounds. ..
  84. Wermuth B, Mäder Heinemann G, Ernst E. Cloning and expression of carbonyl reductase from rat testis. Eur J Biochem. 1995;228:473-9 pubmed
    ..We conclude that carbonyl reductase from rat testis and human tissues represent species-specific forms of the same enzyme. ..
  85. Cheon M, Shim K, Kim S, Hara A, Lubec G. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV). Amino Acids. 2003;25:41-7 pubmed
    ..We are systematically quantifying all proteins whose genes are encoded on chromosome 21 and these studies may provide a better understanding of genotype-phenotype correlation in DS. ..
  86. Varatharajan S, Abraham A, Zhang W, Shaji R, Ahmed R, Abraham A, et al. Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia. Eur J Clin Pharmacol. 2012;68:1577-86 pubmed publisher
    ..study aimed to investigate the role of expression of daunorubicin-metabolizing enzymes carbonyl reductase 1 and 3 (CBR1 and CBR3) on the in vitro cytotoxicity of daunorubicin in primary acute myeloid leukemia (AML) cells and the effect ..
  87. Kalabus J, Cheng Q, Blanco J. MicroRNAs differentially regulate carbonyl reductase 1 (CBR1) gene expression dependent on the allele status of the common polymorphic variant rs9024. PLoS ONE. 2012;7:e48622 pubmed publisher
    ..To date, their involvement in the regulation of CBR1 is unknown...
  88. Miura T, Taketomi A, Nishinaka T, Terada T. Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2. Chem Biol Interact. 2013;202:126-35 pubmed publisher
    Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous ..
  89. Kanaujiya J, Lochab S, Kapoor I, Pal P, Datta D, Bhatt M, et al. Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells. Proteomics. 2013;13:2100-12 pubmed publisher
    ..In nutshell, these data indicate that MS-based proteomics approach identifies a novel ER? interacting protein Profilin1 that serves as a putative corepressor of ER? functions. ..
  90. Malátková P, Skarka A, Musilova K, Wsol V. Reductive metabolism of tiaprofenic acid by the human liver and recombinant carbonyl reducing enzymes. Chem Biol Interact. 2017;276:121-126 pubmed publisher
    ..b>CBR1 was identified as the reductase of tiaprofenic acid with high specific activity (56,965 ± 6741 pmol mg of ..
  91. Caballero N, Zuriaga M, Tamarit J, Serra P. Dynamic heterogeneity in an orientational glass. J Chem Phys. 2017;147:184501 pubmed publisher
    The family of compounds CBrnCl4-n has been proven helpful in unraveling microscopic mechanisms responsible for glassy behavior...
  92. Ayzac V, Raynal M, Isare B, Idé J, Brocorens P, Lazzaroni R, et al. Probing halogen-halogen interactions in solution. Phys Chem Chem Phys. 2017;19:32443-32450 pubmed publisher
    ..We have designed a supramolecular balance that allows detecting BrBr interactions between CBr3 groups in solution and close to room temperature...