CBP

Summary

Gene Symbol: CBP
Description: CREB binding protein
Alias: CBP, KAT3A, RSTS, RSTS1, CREB-binding protein
Species: human
Products:     CBP

Top Publications

  1. Coupry I, Monnet L, Attia A, Taine L, Lacombe D, Arveiler B. Analysis of CBP (CREBBP) gene deletions in Rubinstein-Taybi syndrome patients using real-time quantitative PCR. Hum Mutat. 2004;23:278-84 pubmed
    ..RTS was shown to be associated with disruption of the CREB-binding protein gene CBP (CREBBP), either by gross chromosomal rearrangements or by point mutations...
  2. Poon B, Chen I. Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA. J Virol. 2003;77:3962-72 pubmed
    ..These results attribute a new function to HIV-1 Vpr and implicate Vpr as a critical component in expression from unintegrated HIV-1 DNA...
  3. Matsuda S, Harries J, Viskaduraki M, Troke P, Kindle K, Ryan C, et al. A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP. J Biol Chem. 2004;279:14055-64 pubmed
    CREB-binding protein (CBP) and p300 contain modular domains that mediate protein-protein interactions with a wide variety of nuclear factors...
  4. Kuo H, Chang C, Jeng J, Hu H, Lin D, Maul G, et al. SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proc Natl Acad Sci U S A. 2005;102:16973-8 pubmed
    ..Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling ..
  5. Caravatta L, Sancilio S, Di Giacomo V, Rana R, Cataldi A, Di Pietro R. PI3-K/Akt-dependent activation of cAMP-response element-binding (CREB) protein in Jurkat T leukemia cells treated with TRAIL. J Cell Physiol. 2008;214:192-200 pubmed
    ..These results let us hypothesize that CREB activation can be an important player in the complex cross-talk among pro- and anti-apoptotic pathways in this peculiar cell model. ..
  6. Mullighan C, Zhang J, Kasper L, Lerach S, Payne Turner D, Phillips L, et al. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature. 2011;471:235-9 pubmed publisher
    ..encodes the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CREBBP, also known as CBP)...
  7. Kindle K, Troke P, Collins H, Matsuda S, Bossi D, Bellodi C, et al. MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol. 2005;25:988-1002 pubmed
    ..encoding the acetyltransferase MOZ or MORF with genes encoding the nuclear receptor coactivator TIF2, p300, or CBP. Here we show that MOZ-TIF2 acts as a dominant inhibitor of the transcriptional activities of CBP-dependent ..
  8. Pasqualucci L, Dominguez Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature. 2011;471:189-95 pubmed publisher
    ..These results identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell non-Hodgkin's lymphoma, with direct implications for the use of drugs targeting acetylation/deacetylation mechanisms. ..
  9. Garbati M, Alço G, Gilmore T. Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8. Cancer Lett. 2010;291:237-45 pubmed publisher
    ..However, due to a deletion in the EP300 locus, only a C-terminally truncated form of p300 is expressed in RC-K8 cells. These results suggest a role for p300 in REL-mediated oncogenic activity in B lymphoma. ..

More Information

Publications71

  1. Yuan Z, Guan Y, Chatterjee D, Chin Y. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science. 2005;307:269-73 pubmed
  2. Wang A, Ikura T, Eto K, Ota M. Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry. Biochem Biophys Res Commun. 2004;325:1509-16 pubmed
    ..Because the CBP/p300 histone acetyltransferase are also known to be involved in cell proliferation, we examined the molecular and ..
  3. Huang W, Ju T, Hung M, Chen C. Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell. 2007;26:75-87 pubmed
    b>CBP plays a central role in coordinating and integrating multiple signaling pathways. Competition between NF-kappaB and p53 for CBP is a crucial determinant of whether a cell proliferates or undergoes apoptosis...
  4. Hogan T, Nonnemacher M, Krebs F, Henderson A, Wigdahl B. HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific. Biomed Pharmacother. 2003;57:41-8 pubmed
    ..These studies suggest that Vpr may regulate the interaction of members of the C/EBP transcription factor family with the viral LTR. ..
  5. Kishimoto M, Kohno T, Okudela K, Otsuka A, Sasaki H, Tanabe C, et al. Mutations and deletions of the CBP gene in human lung cancer. Clin Cancer Res. 2005;11:512-9 pubmed
    ..analysis led us to detect a homozygous deletion at the cyclic AMP response element binding protein-binding protein (CBP) locus in a lung cancer cell line...
  6. Lee Y, Coonrod S, Kraus W, Jelinek M, Stallcup M. Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A. 2005;102:3611-6 pubmed
    ..and retinoid receptors], the histone acetyltransferases cAMP response element binding protein binding protein (CBP) and p300 and the histone methyltransferase coactivator-associated arginine methyltransferase (CARM1) depends on ..
  7. Bartsch O, Schmidt S, Richter M, Morlot S, Seemanova E, Wiebe G, et al. DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS. Hum Genet. 2005;117:485-93 pubmed
    Rubinstein-Taybi syndrome (RSTS) is a distinct dominant disorder characterized by short stature, typical face, broad angulated thumbs and halluces, and mental retardation...
  8. Iioka T, Furukawa K, Yamaguchi A, Shindo H, Yamashita S, Tsukazaki T. P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain. J Bone Miner Res. 2003;18:1419-29 pubmed
    ..We describe here that the general coactivator p300/CBP controls the transcription activity of Cart1 through acetylation of a lysine residue that is highly conserved in ..
  9. Evans P, Zhang W, Chen X, Yang J, Bhakat K, Liu C. Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem. 2007;282:33994-4002 pubmed
    ..We further made the novel observation that endogenous KLF4 is acetylated by p300/CBP in vivo and that mutations of the acetylated lysines resulted in a decreased ability of KLF4 to activate target ..
  10. Chang C, Chuang H, Yu C, Yao T, Chen H. Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. Mol Cell Biol. 2005;25:8401-14 pubmed
    ..Furthermore, PKA treatment stimulates the association of GCMa with CBP and increases GCMa acetylation...
  11. Wu R, Qin J, Yi P, Wong J, Tsai S, Tsai M, et al. Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell. 2004;15:937-49 pubmed
    ..Our results uncovered an additional level of transcriptional regulation whereby specific modulations of SRC-3 phosphorylation allow this coactivator to function as a regulatable integrator for diverse signaling pathways in cells. ..
  12. Kino T, Gragerov A, Slobodskaya O, Tsopanomichalou M, Chrousos G, Pavlakis G. Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators. J Virol. 2002;76:9724-34 pubmed
    ..tumor virus (MMTV) promoter and of the Tat-induced HIV-1 long terminal repeat promoter by directly binding to p300/CBP coactivators...
  13. Kalkhoven E, Roelfsema J, Teunissen H, den Boer A, Ariyurek Y, Zantema A, et al. Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome. Hum Mol Genet. 2003;12:441-50 pubmed
    Disruption of one copy of the human CREB binding protein (CBP or CREBBP) gene leads to the Rubinstein-Taybi syndrome (RTS), a developmental disorder characterized by retarded growth and mental functions, broad thumbs, broad big toes and ..
  14. Lee C, Ferreon J, Ferreon A, Arai M, Wright P. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A. 2010;107:19290-5 pubmed publisher
    ..Although acetylation of p53 by CREB-binding protein (CBP)/p300 is known to be indispensable for p53 activation, the role of phosphorylation, and in particular multisite ..
  15. Kim Y, Ma H, Oehler V, Gang E, Nguyen C, Masiello D, et al. The gamma catenin/CBP complex maintains survivin transcription in ?-catenin deficient/depleted cancer cells. Curr Cancer Drug Targets. 2011;11:213-25 pubmed
    Previously, we demonstrated that survivin expression is CBP/?-catenin/TCF-dependent...
  16. Tang Y, Zhao W, Chen Y, Zhao Y, Gu W. Acetylation is indispensable for p53 activation. Cell. 2008;133:612-26 pubmed publisher
    ..Our study identifies p53 acetylation as an indispensable event that destabilizes the p53-Mdm2 interaction and enables the p53-mediated stress response. ..
  17. Megiorni F, Indovina P, Mora B, Mazzilli M. Minor expression of fascin-1 gene (FSCN1) in NTera2 cells depleted of CREB-binding protein. Neurosci Lett. 2005;381:169-74 pubmed
    CREB-binding protein (CBP) is a transcriptional coactivator whose mutations may cause a generalized perturbation of gene expression. We silenced the CBP gene in NT2 neuronal precursor cells by RNA interference...
  18. Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford M, et al. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007;27:120-34 pubmed
    ..hormone receptors and facilitates transcription by directly recruiting accessory factors such as acetyltransferase CBP/p300 and the coactivator arginine methyltransferase CARM1...
  19. Stauffer D, Chang B, Huang J, Dunn A, Thayer M. p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. J Biol Chem. 2007;282:9678-87 pubmed
    The highly related acetyltransferases, p300 and CREB-binding protein (CBP) are coactivators of signal-responsive transcriptional activation...
  20. Shi D, Pop M, Kulikov R, Love I, Kung A, Kung A, et al. CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. Proc Natl Acad Sci U S A. 2009;106:16275-80 pubmed publisher
    p300 and CREB-binding protein (CBP) act as multifunctional regulators of p53 via acetylase and polyubiquitin ligase (E4) activities...
  21. Das C, Lucia M, Hansen K, Tyler J. CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature. 2009;459:113-7 pubmed publisher
    ..Here we demonstrate that the histone acetyl transferase CBP (also known as Nejire) in flies and CBP and p300 (Ep300) in humans acetylate H3K56, whereas Drosophila Sir2 and ..
  22. Roelfsema J, White S, Ariyurek Y, Bartholdi D, Niedrist D, Papadia F, et al. Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease. Am J Hum Genet. 2005;76:572-80 pubmed
    ..protein is essential for normal development, since inactivation of one allele causes Rubinstein-Taybi syndrome (RSTS)...
  23. Ward R, Johnson M, Shridhar V, van Deursen J, Couch F. CBP truncating mutations in ovarian cancer. J Med Genet. 2005;42:514-8 pubmed
  24. Jung S, Malovannaya A, Wei J, O Malley B, Qin J. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol. 2005;19:2451-65 pubmed
    ..We hope that the electronic availability of these data to the general scientific community will facilitate generation and testing of new hypotheses to further our understanding of nuclear receptor signaling and coactivator functions. ..
  25. Crowe D, Lee M. New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. Breast Cancer Res. 2006;8:R1 pubmed
    ..BRCA1 interacts with coactivators such as p300 and CREB-binding protein (CBP) to activate target gene transcription...
  26. Collins H, Kindle K, Matsuda S, Ryan C, Troke P, Kalkhoven E, et al. MOZ-TIF2 alters cofactor recruitment and histone modification at the RARbeta2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators. J Biol Chem. 2006;281:17124-33 pubmed
    MOZ-TIF2 and MOZ-CBP are leukemogenic fusion proteins associated with therapy-induced acute myeloid leukemia. These proteins are thought to subvert normal gene expression in differentiating hematopoietic progenitor cells...
  27. Chen L, Mu Y, Greene W. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 2002;21:6539-48 pubmed
    ..We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and ..
  28. Braganca J, Eloranta J, Bamforth S, Ibbitt J, Hurst H, Bhattacharya S. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem. 2003;278:16021-9 pubmed
    The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator...
  29. Ianculescu I, Wu D, Siegmund K, Stallcup M. Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells. J Biol Chem. 2012;287:4000-13 pubmed publisher
    The protein acetyltransferases p300 and cAMP response element-binding protein binding protein (CBP) are homologous, ubiquitously expressed proteins that interact with hundreds of proteins involved in transcriptional regulation and are ..
  30. Korzus E, Torchia J, Rose D, Xu L, Kurokawa R, McInerney E, et al. Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science. 1998;279:703-7 pubmed
    ..STAT-1)-functionally require distinct components of the coactivator complex, including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or ..
  31. Torchia J, Rose D, Inostroza J, Kamei Y, Westin S, Glass C, et al. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 1997;387:677-84 pubmed
    The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA...
  32. Wu R, Qin J, Hashimoto Y, Wong J, Xu J, Tsai S, et al. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol. 2002;22:3549-61 pubmed
    ..Taken together, our results not only reveal the IKK-mediated phosphorylation of SRC-3 to be a regulated event that plays an important role but also substantiate the role of SRC-3 in multiple signaling pathways. ..
  33. Arias J, Alberts A, Brindle P, Claret F, Smeal T, Karin M, et al. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 1994;370:226-9 pubmed
    ..Recent work describing a phospho-CREB binding protein (CBP) which interacts specifically with the CREB trans-activation domain prompted us to examine whether CBP ..
  34. Tini M, Benecke A, Um S, Torchia J, Evans R, Chambon P. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell. 2002;9:265-77 pubmed
    ..We report that TDG associates with transcriptional coactivators CBP and p300 and that the resulting complexes are competent for both the excision step of repair and histone ..
  35. von Mikecz A, Zhang S, Montminy M, Tan E, Hemmerich P. CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus. J Cell Biol. 2000;150:265-73 pubmed
    ..Here we analyzed the nuclear distribution of the transcriptional coactivators CREB-binding protein (CBP)/p300 in situ by confocal laser scanning microscopy, and in vivo complex formation by coimmunoprecipitation...
  36. Castillo A, Jimenez Lara A, Tolon R, Aranda A. Synergistic activation of the prolactin promoter by vitamin D receptor and GHF-1: role of the coactivators, CREB-binding protein and steroid hormone receptor coactivator-1 (SRC-1). Mol Endocrinol. 1999;13:1141-54 pubmed
    ..Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 ..
  37. Bordoli L, Hüsser S, Lüthi U, Netsch M, Osmani H, Eckner R. Functional analysis of the p300 acetyltransferase domain: the PHD finger of p300 but not of CBP is dispensable for enzymatic activity. Nucleic Acids Res. 2001;29:4462-71 pubmed
    ..In contrast, less information is available regarding mechanistic and regulatory aspects of p300/CBP AT function...
  38. Chai Y, Cui J, Shao N, Shyam E, Reddy P, Rao V. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Oncogene. 1999;18:263-8 pubmed
    ..BRCA1 splice variants BRCA1a (p110) and BRCA1b (p100) associates with CBP/p300 co-activators...
  39. Kwok R, Lundblad J, Chrivia J, Richards J, Bachinger H, Brennan R, et al. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 1994;370:223-6 pubmed
    ..We have previously identified a nuclear protein of M(r)265K, CBP, that binds specifically to the PKA-phosphorylated form of CREB...
  40. Yamamoto H, Kihara Negishi F, Yamada T, Suzuki M, Nakano T, Oikawa T. Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb. Cell Growth Differ. 2002;13:69-75 pubmed
    ..1 interacts with the transcriptional coactivator CREB-binding protein (CBP)...
  41. Puri P, Sartorelli V, Yang X, Hamamori Y, Ogryzko V, Howard B, et al. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol Cell. 1997;1:35-45 pubmed
    PCAF is a histone acetyltransferase that associates with p300/CBP and competes with E1A for access to them...
  42. Kitabayashi I, Aikawa Y, Nguyen L, Yokoyama A, Ohki M. Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. EMBO J. 2001;20:7184-96 pubmed
    ..MOZ, as well as CBP and MOZ-CBP, can acetylate AML1 in vitro...
  43. Sheppard H, Harries J, Hussain S, Bevan C, Heery D. Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1. Mol Cell Biol. 2001;21:39-50 pubmed
    ..proteins, including steroid receptor coactivator 1 (SRC1) and its homologues and the general coactivators CREB binding protein (CBP) and p300...
  44. Nakajima T, Uchida C, Anderson S, Lee C, Hurwitz J, Parvin J, et al. RNA helicase A mediates association of CBP with RNA polymerase II. Cell. 1997;90:1107-12 pubmed
    The coactivator CBP has been proposed to stimulate the expression of certain signal-dependent genes via its association with RNA polymerase II complexes...
  45. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell. 1996;85:403-14 pubmed
    ..Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in ..
  46. Voegel J, Heine M, Tini M, Vivat V, Chambon P, Gronemeyer H. The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998;17:507-19 pubmed
    ..TIF2 AD1 activity appears to be mediated through CBP, as AD1 could not be separated mutationally from the CBP interaction domain...
  47. Neish A, Anderson S, Schlegel B, Wei W, Parvin J. Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res. 1998;26:847-53 pubmed
    ..Earlier experiments have demonstrated that the breast cancer-associated tumor suppressor BRCA1 and the CREB binding protein (CBP) were associated with the holoenzyme complex...
  48. Impey S, Fong A, Wang Y, Cardinaux J, Fass D, Obrietan K, et al. Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. Neuron. 2002;34:235-44 pubmed
    ..persistent CREB phosphorylation and CaM kinase IV (CaMKIV) responsible for phosphorylating the CREB coactivator, CBP. Ser301 of CBP was identified as a major target of CaMKIV phosphorylation in vitro and in vivo...
  49. Panagopoulos I, Fioretos T, Isaksson M, Samuelsson U, Billström R, Strombeck B, et al. Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13). Hum Mol Genet. 2001;10:395-404 pubmed
    The CBP gene at 16p13 fuses to MOZ and MLL as a result of the t(8;16)(p11;p13) in acute (myelo)monocytic leukemias (AML M4/M5) and the t(11;16)(q23;p13) in treatment-related AML, respectively...
  50. Bex F, Yin M, Burny A, Gaynor R. Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300. Mol Cell Biol. 1998;18:2392-405 pubmed
    ..Transcriptional activation of these pathways is mediated by the actions of the related coactivators CREB binding protein (CBP) and p300...
  51. Radhakrishnan I, Pérez Alvarado G, Parker D, Dyson H, Montminy M, Wright P. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell. 1997;91:741-52 pubmed
    ..activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner...
  52. Doucas V, Tini M, Egan D, Evans R. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc Natl Acad Sci U S A. 1999;96:2627-32 pubmed
    ..Here, we demonstrate that the cAMP enhancer binding protein (CREB)-binding protein (CBP) associates with PML in vitro and is recruited to the PODs in vivo...
  53. Fan S, Ma Y, Wang C, Yuan R, Meng Q, Wang J, et al. p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res. 2002;62:141-51 pubmed
    ..On the other hand, BRCA1 failed to alter the expression of the CREB binding protein (CBP), the structural and functional homologue of p300, in any of these cell types...
  54. Lin R, Heylbroeck C, Pitha P, Hiscott J. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol. 1998;18:2986-96 pubmed
    ..Interestingly, virus infection resulted in the association of IRF-3 with the CREB binding protein (CBP) coactivator, as detected by coimmunoprecipitation with anti-CBP antibody, an interaction mediated by ..
  55. Lill N, Grossman S, Ginsberg D, DeCaprio J, Livingston D. Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997;387:823-7 pubmed
    The adenovirus E1A and SV40 large-T-antigen oncoproteins bind to members of the p300/CBP transcriptional coactivator family. Binding of p300/CBP is implicated in the transforming mechanisms of E1A and T-antigen oncoproteins...
  56. Heery D, Kalkhoven E, Hoare S, Parker M. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature. 1997;387:733-6 pubmed
    ..and promotes their association with a diverse group of nuclear proteins, including SRC-1/p160, TIF-2/GRIP-1 and CBP/p300 which function as co-activators of transcription, and RIP-140, TIF-1 and TRIP-1/SUG-1 whose functions are ..
  57. Petrij F, Giles R, Dauwerse H, Saris J, Hennekam R, Masuno M, et al. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature. 1995;376:348-51 pubmed
    ..Here we report that all these breakpoints are restricted to a region that contains the gene for the human CREB binding protein (CBP), a nuclear protein participating as a co-activator in cyclic-AMP-regulated gene expression...
  58. Cho H, Orphanides G, Sun X, Yang X, Ogryzko V, Lees E, et al. A human RNA polymerase II complex containing factors that modify chromatin structure. Mol Cell Biol. 1998;18:5355-63 pubmed
    ..This complex contains the Srb proteins, the Swi-Snf complex, and the histone acetyltransferases CBP and PCAF in addition to RNA polymerase II. Notably, the general transcription factors are absent from this complex...
  59. Panagopoulos I, Isaksson M, Lindvall C, Bjorkholm M, Ahlgren T, Fioretos T, et al. RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13). Genes Chromosomes Cancer. 2000;28:415-24 pubmed
    ..The t(8;16) fuses the MOZ gene from 8p11 with the CBP (also named CREBBP) gene from 16p13...
  60. Nakajima T, Fukamizu A, Takahashi J, Gage F, Fisher T, Blenis J, et al. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell. 1996;86:465-74 pubmed
    ..Ras with insulin or NGF stimulated recruitment of the S6 kinase pp90RSK to the signal-dependent coactivator CBP. Formation of the pp90RSK-CBP complex occurred with high stoichiometry and persisted for 6-8 hr following growth ..
  61. Xu W, Chen H, Du K, Asahara H, Tini M, Emerson B, et al. A transcriptional switch mediated by cofactor methylation. Science. 2001;294:2507-11 pubmed
    ..based on the controlled methylation of nucleosome and the transcriptional cofactors, the CREB-binding proteins (CBP)/p300...
  62. Lundblad J, Kwok R, Laurance M, Harter M, Goodman R. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature. 1995;374:85-8 pubmed
    The 265K nuclear protein CBP was initially identified as a co-activator for the protein kinase A (PKA)-phosphorylated form of the transcription factor CREB...