Gene Symbol: CBFB
Description: core-binding factor subunit beta
Alias: PEBP2B, core-binding factor subunit beta, CBF-beta, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 beta subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit, core-binding factor beta subunit, polyomavirus enhancer binding protein 2, beta subunit
Species: human
Products:     CBFB

Top Publications

  1. Hyde R, Liu P. RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1). J Cell Biochem. 2010;110:1039-45 pubmed publisher
    ..Both of these rearrangements result in the formation of fusion proteins, CBFB-MYH11 and AML1-ETO, respectively, that involve members of the CBF family of transcription factors...
  2. Bravo J, Li Z, Speck N, Warren A. The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001;8:371-8 pubmed
    We have determined the structure, at 2.6 A resolution, of the AML1 (Runx1) Runt domain--CBF beta--DNA ternary complex, the most common target for mutations in human leukemia...
  3. Wee H, Voon D, Bae S, Ito Y. PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. Blood. 2008;112:3777-87 pubmed publisher
    ..the in vitro disruption of this phosphorylation cascade by multiple leukemogenic genetic defects targeting RUNX1/CBFB. In particular, the oncogenic protein PEBP2-beta-SMMHC prevents RUNX1/p300 phosphorylation by sequestering HIPK2 to ..
  4. Salter J, Lippa G, Belashov I, Wedekind J. Core-binding factor ? increases the affinity between human Cullin 5 and HIV-1 Vif within an E3 ligase complex. Biochemistry. 2012;51:8702-4 pubmed publisher
    ..An additional interface between Cul5 and an N-terminal region of Vif appears to be plausible, which has therapeutic design implications. ..
  5. Wang X, Wang X, Zhang H, Lv M, Zuo T, Wu H, et al. Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-? binding to Vif. Retrovirology. 2013;10:94 pubmed publisher
  6. Matsui Y, Shindo K, Nagata K, Io K, Tada K, Iwai F, et al. Defining HIV-1 Vif residues that interact with CBF? by site-directed mutagenesis. Virology. 2014;449:82-7 pubmed publisher
    ..These results support a model in which HIV-1 Vif residues E88/W89 may participate in binding CBF?. ..
  7. Chiba N, Watanabe T, Nomura S, Tanaka Y, Minowa M, Niki M, et al. Differentiation dependent expression and distinct subcellular localization of the protooncogene product, PEBP2beta/CBFbeta, in muscle development. Oncogene. 1997;14:2543-52 pubmed
    The Pebpb2/Cbfb gene encodes the non-DNA binding subunit of the heterodimeric transcription factor, PEBP2/CBF...
  8. Tanaka Y, Watanabe T, Chiba N, Niki M, Kuroiwa Y, Nishihira T, et al. The protooncogene product, PEBP2beta/CBFbeta, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures. Oncogene. 1997;15:677-83 pubmed
    The Pebpb2/Cbfb gene encodes the non-DNA binding beta subunit of the heterodimeric transcription factor, PEBP2/CBF, and has been implicated in a subtype of human acute myeloid leukemia, as well as being indispensable for the development ..
  9. Kundu M, Chen A, Anderson S, Kirby M, Xu L, Castilla L, et al. Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood. 2002;100:2449-56 pubmed
    ..Inv(16)(p13;q22) is found in almost all cases of AML M4Eo and results in the fusion of CBFB with MYH11, the gene encoding smooth muscle myosin heavy chain...

More Information

Publications156 found, 100 shown here

  1. Zhang W, Du J, Evans S, Yu Y, Yu X. T-cell differentiation factor CBF-? regulates HIV-1 Vif-mediated evasion of host restriction. Nature. 2011;481:376-9 pubmed publisher
    ..Considering the importance of the interaction between Vif and CBF-?, disrupting this interaction represents an attractive pharmacological intervention against HIV-1. ..
  2. Jäger S, Kim D, Hultquist J, Shindo K, LaRue R, Kwon E, et al. Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature. 2011;481:371-5 pubmed publisher
    ..Methods of disrupting the CBF-β-Vif interaction might enable HIV-1 restriction and provide a supplement to current antiviral therapies that primarily target viral proteins. ..
  3. Hultquist J, Binka M, LaRue R, Simon V, Harris R. Vif proteins of human and simian immunodeficiency viruses require cellular CBF? to degrade APOBEC3 restriction factors. J Virol. 2012;86:2874-7 pubmed publisher
  4. Zhou X, Evans S, Han X, Liu Y, Yu X. Characterization of the interaction of full-length HIV-1 Vif protein with its key regulator CBF? and CRL5 E3 ubiquitin ligase components. PLoS ONE. 2012;7:e33495 pubmed publisher
  5. Hultquist J, McDougle R, Anderson B, Harris R. HIV type 1 viral infectivity factor and the RUNX transcription factors interact with core binding factor ? on genetically distinct surfaces. AIDS Res Hum Retroviruses. 2012;28:1543-51 pubmed publisher
    ..This mutant still bound RUNX and stimulated RUNX-dependent transcription. These separation-of-function mutants demonstrate that HIV-1 Vif and the RUNX transcription factors interact with cellular CBF? on genetically distinct surfaces. ..
  6. Du J, Zhao K, Rui Y, Li P, Zhou X, Zhang W, et al. Differential requirements for HIV-1 Vif-mediated APOBEC3G degradation and RUNX1-mediated transcription by core binding factor beta. J Virol. 2013;87:1906-11 pubmed publisher
    ..The important interaction domains that are uniquely required for Vif but not RUNX function represent novel targets for the development of HIV inhibitors. ..
  7. Zhou X, Han X, Zhao K, Du J, Evans S, Wang H, et al. Dispersed and conserved hydrophobic residues of HIV-1 Vif are essential for CBF? recruitment and A3G suppression. J Virol. 2014;88:2555-63 pubmed publisher
    ..Therefore, information from this study will help people to further understand how Vif acts against host antiviral mechanism, which is important for novel anti-HIV-1 drug development. ..
  8. Guo Y, Dong L, Qiu X, Wang Y, Zhang B, Liu H, et al. Structural basis for hijacking CBF-? and CUL5 E3 ligase complex by HIV-1 Vif. Nature. 2014;505:229-33 pubmed publisher
    ..Together, our data reveal the structural basis for Vif hijacking of the CBF-? and CUL5 E3 ligase complex, laying a foundation for rational design of novel anti-HIV drugs. ..
  9. Sakr R, Schizas M, Carniello J, Ng C, Piscuoglio S, Giri D, et al. Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships. Mol Oncol. 2016;10:360-70 pubmed publisher
    ..the most frequently mutated genes being CDH1 (56% and 66%, respectively), PIK3CA (41% and 52%, respectively) and CBFB (12% and 19%, respectively)...
  10. Hantel A, Stock W, Kosuri S. Molecular Minimal Residual Disease Testing in Acute Myeloid Leukemia: A Review for the Practicing Clinician. Clin Lymphoma Myeloma Leuk. 2018;18:636-647 pubmed publisher
    ..To date, there is robust evidence for testing NPM1, CBFB-MYH11, and RUNX1/RUNXT1 mutations using this approach, though the best timing and threshold level for each mutation ..
  11. Panagopoulos I, Gorunova L, Brandal P, Garnes M, Tierens A, Heim S. Myeloid leukemia with t(7;21)(p22;q22) and 5q deletion. Oncol Rep. 2013;30:1549-52 pubmed publisher
    ..fusion protein would contain the Runt homology domain (RHD), which is responsible for heterodimerization with CBFB and for DNA binding, and the catalytic UCH (ubiquitin carboxyl terminal hydroxylase) domain of the USP42 protein...
  12. Anderson B, Harris R. Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis. Sci Adv. 2015;1:e1500296 pubmed publisher
  13. Sun X, Zhang W, Ramdas L, Stivers D, Jones D, Kantarjian H, et al. Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping. Mod Pathol. 2007;20:811-20 pubmed
    ..These findings most likely represent the functional consequences of the abnormal chimeric protein CBFbeta-MYH11, which is unique to this disease, and suggest that NF-kappaB is a potential therapeutic target for treating M4Eo patients. ..
  14. Lim K, Park N, Che X, Han M, Jeong J, Kim S, et al. Core binding factor β of osteoblasts maintains cortical bone mass via stabilization of Runx2 in mice. J Bone Miner Res. 2015;30:715-22 pubmed publisher
    ..Null mutations of Cbfb result in embryonic death, which can be rescued by restoring fetal hematopoiesis but only until birth, where bone ..
  15. Platzbecker U, Middeke J, Sockel K, Herbst R, Wolf D, Baldus C, et al. Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicentre, phase 2 trial. Lancet Oncol. 2018;19:1668-1679 pubmed publisher
    ..baseline by either quantitative PCR for mutant NPM1, leukaemia-specific fusion genes (DEK-NUP214, RUNX1-RUNX1T1, CBFb-MYH11), or analysis of donor-chimaerism in flow cytometry-sorted CD34-positive cells in patients who received ..
  16. Lee Thacker S, Choi Y, Taniuchi I, Takarada T, Yoneda Y, Ko C, et al. Core Binding Factor β Expression in Ovarian Granulosa Cells Is Essential for Female Fertility. Endocrinology. 2018;159:2094-2109 pubmed publisher
    ..of Runx1 and Runx2 is highly induced by the luteinizing hormone (LH) surge in ovulatory follicles, whereas Cbfb is constitutively expressed...
  17. Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, et al. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood. 2011;118:6544-52 pubmed publisher
    ..1 regulatory regions, and decreased PU.1 expression. The interaction between MLL and AML1 provides a mechanism for the sequence-specific binding of MLL to DNA, and identifies RUNX1 target genes as potential effectors of MLL function. ..
  18. Kristensen T, Preiss B, Broesby Olsen S, Vestergaard H, Friis L, Møller M. Systemic mastocytosis is uncommon in KIT D816V mutation positive core-binding factor acute myeloid leukemia. Leuk Lymphoma. 2012;53:1338-44 pubmed publisher
    ..1;q22)/t(16;16)(p13.1;q22); CBFB-MYH11 chromosomal rearrangements, but whether the mutation is indicative of associated SM is unclear...
  19. Matsui Y, Shindo K, Nagata K, Yoshinaga N, Shirakawa K, Kobayashi M, et al. Core Binding Factor ? Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation. J Biol Chem. 2016;291:24892-24899 pubmed
    ..Our data provide new insights into the mechanism of Vif augmentation by CBF?. ..
  20. Fan Q, Wu P, Dai G, Zhang G, Zhang T, Xue Q, et al. Identification of 19 loci for reproductive traits in a local Chinese chicken by genome-wide study. Genet Mol Res. 2017;16: pubmed publisher
    ..These SNPs were located near to or in 17 genes including FAM184B, HTT, KCNH7, CDC42BPA, KCNIP4, GJA5, CBFB, and GPC6...
  21. Assaf N, El Cheikh J, Bazarbachi A, Salem Z, Farra C, Chakhachiro Z, et al. Molecular profiling of adult acute myeloid and lymphoid leukemia in a major referral center in Lebanon: a 10-year experience report and review of the literature. Mol Biol Rep. 2019;46:2003-2011 pubmed publisher
    ..molecular diagnostics laboratory consists of a validated lab developed RT-PCR for the detection of RUNX1/RUNX1T1, CBFB/MYH11, KMT2A/MLLT3, PML-RARA, and BCR-ABL and mutations in the FLT3 receptor, NPM1, c-kit and CEPBA genes...
  22. Alvarez S, Suela J, Valencia A, Fernández A, Wunderlich M, Agirre X, et al. DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia. PLoS ONE. 2010;5:e12197 pubmed publisher
    ..In contrast, fusion genes such as AML1/ETO or CBFB/MYH11 failed to reproduce the epigenetic signature observed in the patients...
  23. Han X, Liang W, Hua D, Zhou X, Du J, Evans S, et al. Evolutionarily conserved requirement for core binding factor beta in the assembly of the human immunodeficiency virus/simian immunodeficiency virus Vif-cullin 5-RING E3 ubiquitin ligase. J Virol. 2014;88:3320-8 pubmed publisher
    ..Considering the importance of the interaction between Vif and CBF-? in viral CRL5 function and HIV-1 replication, disrupting this interaction is an attractive strategy against HIV-1. ..
  24. Zhang W, Wang H, Li Z, Liu X, Liu G, Harris R, et al. Cellular requirements for bovine immunodeficiency virus Vif-mediated inactivation of bovine APOBEC3 proteins. J Virol. 2014;88:12528-40 pubmed publisher
    ..This novel mechanism for assembly of the BIV Vif-APOBEC3 ubiquitin ligase complex advances our understanding of viral hijacking of host E3 ubiquitin ligases and illustrates the evolutionary flexibility of lentiviruses. ..
  25. Yoshikawa R, Takeuchi J, Yamada E, Nakano Y, Ren F, Tanaka H, et al. Vif determines the requirement for CBF-β in APOBEC3 degradation. J Gen Virol. 2015;96:887-92 pubmed publisher
    ..Here, we determined the sequence of feline CBFB and performed phylogenetic analyses. These analyses revealed that mammalian CBFB is under purifying selection...
  26. Zhang S, Zhong L, Chen B, Pan T, Zhang X, Liang L, et al. Identification of an HIV-1 replication inhibitor which rescues host restriction factor APOBEC3G in Vif-APOBEC3G complex. Antiviral Res. 2015;122:20-7 pubmed publisher
    ..01 μM) that efficiently protected APOBEC3G protein by targeting Vif-APOBEC3G complex. The co-immunoprecipitation and docking studies indicated that compound ZBMA-1 affected the binding of Elongin C with Vif protein. ..
  27. Bae S, Takahashi E, Zhang Y, Ogawa E, Shigesada K, Namba Y, et al. Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. Gene. 1995;159:245-8 pubmed
    ..11-p36.13 in the human chromosome and encodes a 415-aa protein. PEBP2 alpha C forms a heterodimer with PEBP2 beta, binds to the PEBP2 site and transactivates transcription, similar to PEBP2 alpha A and PEBP2 alpha B.
  28. Fujieda A, Nishii K, Tamaru T, Otsuki S, Kobayashi K, Monma F, et al. Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome: case report and review of literature. Leuk Res. 2006;30:1053-7 pubmed
    ..The chromosomal analysis was normal, but molecular analysis detected the CBFB/MYH11 fusion gene in the blasts...
  29. Fischer J, Rossetti S, Datta A, Eng K, Beghini A, Sacchi N. miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia. Mol Cancer. 2015;14:7 pubmed publisher
    Core Binding Factor acute myeloid leukemia (CBF-AML) with t(8;21) RUNX1-MTG8 or inv(16) CBFB-MYH11 fusion proteins often show upregulation of wild type or mutated KIT receptor...
  30. Tenno M, Kojo S, Lawir D, Hess I, Shiroguchi K, Ebihara T, et al. Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors. J Exp Med. 2018;215:595-610 pubmed publisher
    ..factor complexes with Runx proteins, and here we show that Cbfβ2, encoded by an RNA splice variant of the Cbfb gene, is essential for extrathymic differentiation of T cell progenitors...
  31. Wang T, Xia C, Dong Y, Chen X, Wang J, Du J. Trim27 confers myeloid hematopoiesis competitiveness by up-regulating myeloid master genes. J Leukoc Biol. 2018;104:799-809 pubmed publisher
    ..myelopoiesis, including Spi1 and Cebpg, up-regulated myeloid proliferation-related signaling genes Nras, Runx1, and Cbfb, up-regulated JAK/STAT signaling inhibitors Socs2, Socs3, and Cish, and up-regulated myeloid maturation-related ..
  32. Levanon D, Goldstein R, Bernstein Y, Tang H, Goldenberg D, Stifani S, et al. Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc Natl Acad Sci U S A. 1998;95:11590-5 pubmed
    ..These data indicate that, in addition to their activity as transcriptional activators, AML1 and LEF-1 can act, through recruitment of the corepressor TLE1, as transcriptional repressors in TCR regulation and Wnt/Wg signaling. ..
  33. Han G, Jing Y, Zhang Y, Yue Z, Hu X, Wang L, et al. Osteogenic differentiation of bone marrow mesenchymal stem cells by adenovirus-mediated expression of leptin. Regul Pept. 2010;163:107-12 pubmed publisher
    ..All the findings suggest that genetic engineering of MSCs to express leptin gene may have potential application in the treatment of several genetic diseases and bone reconstruction. ..
  34. Akhter A, Mughal M, Elyamany G, Sinclair G, Azma R, Masir N, et al. Multiplexed automated digital quantification of fusion transcripts: comparative study with fluorescent in-situ hybridization (FISH) technique in acute leukemia patients. Diagn Pathol. 2016;11:89 pubmed publisher
    ..b>CBFB-MYH11 fusion probes showed moderate sensitivity (57 %) but high specificity (100 %)...
  35. Panagopoulos I, Torkildsen S, Gorunova L, Ulvmoen A, Tierens A, Zeller B, et al. RUNX1 truncation resulting from a cryptic and novel t(6;21)(q25;q22) chromosome translocation in acute myeloid leukemia: A case report. Oncol Rep. 2016;36:2481-2488 pubmed publisher
    ..encodes a truncated protein containing the Runt homology domain responsible for both heterodimerization with CBFB and DNA binding, but lacking the proline-, serine-, and threonine-rich (PST) region which is the transcription ..
  36. Sorour A, Nafea D. Dual color FISH on CBF primary acute myeloid leukemia. Egypt J Immunol. 2008;15:25-31 pubmed
    ..In conclusion, FISH can be used as a complementary technique to identify t(8;21) and inv16/t(16;16) in de novo AML as these abnormalities are difficult to diagnose in most cases by conventional cytogenetics alone...
  37. Hyde R, Zhao L, Alemu L, Liu P. Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice. Leukemia. 2015;29:1771-8 pubmed publisher
    ..smooth muscle myosin heavy chain), the fusion protein generated by the chromosome 16 inversion fusion gene, CBFB-MYH11, is known to initiate leukemogenesis...
  38. Tang F, Xu L, Zhang X, Chen H, Chen Y, Han W, et al. Monitoring of post-transplant CBFB-MYH11 as minimal residual disease, rather than KIT mutations, can predict relapse after allogeneic haematopoietic cell transplantation in adults with inv(16) acute myeloid leukaemia. Br J Haematol. 2018;180:448-451 pubmed publisher
  39. Komori T. Roles of Runx2 in Skeletal Development. Adv Exp Med Biol. 2017;962:83-93 pubmed publisher
    ..Runx2 enhances osteoclastogenesis by regulating Rankl. Cbfb, which is a co-transcription factor for Runx family proteins, plays an important role in skeletal development by ..
  40. Boissel N, Renneville A, Leguay T, Lefebvre P, Recher C, Lecerf T, et al. Dasatinib in high-risk core binding factor acute myeloid leukemia in first complete remission: a French Acute Myeloid Leukemia Intergroup trial. Haematologica. 2015;100:780-5 pubmed publisher
    ..cytogenetically defined by t(8;21) or inv(16)/t(16;16) rearrangements, disrupting RUNX1 (previously CBFA/AML1) or CBFB transcription factor functions...
  41. Park N, Lim K, Han M, Che X, Park C, Kim J, et al. Core Binding Factor β Plays a Critical Role During Chondrocyte Differentiation. J Cell Physiol. 2016;231:162-71 pubmed publisher
    ..Here we address the role of Cbfβ in cartilage by generating chondrocyte-specific Cbfβ-deficient mice (Cbfb(Δch/Δch) ) from Cbfb-floxed mice crossed with mice expressing Cre from the Col2a1 promoter...
  42. Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, et al. Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. J Bone Miner Res. 2016;31:1391-404 pubmed publisher
    b>Cbfb is a cotranscription factor that forms a heterodimer with Runx proteins Runx1, Runx2, and Runx3. It is required for fetal liver hematopoiesis and skeletal development...
  43. Ishikawa Y. Genetic abnormalities in core binding factor acute myeloid leukemia. Rinsho Ketsueki. 2017;58:991-998 pubmed publisher
    ..The t (8;21) and inv16 (q16q16) /t (16;16) (q16;q16) result in RUNX1-RUNX1T1 and CBFB-MYH11 fusion genes, respectively; however, the fusion proteins encoded by these genes alone are insufficient for ..
  44. Zhao Z, Peng H, Lan C, Zheng Y, Fang L, Li J. Imbalance learning for the prediction of N6-Methylation sites in mRNAs. BMC Genomics. 2018;19:574 pubmed publisher
    ..The case studies on gene c-Jun and CBFB demonstrate the detailed prediction capacity to improve the prediction performance...
  45. Hájková H, Fritz M, Haškovec C, Schwarz J, Šálek C, Marková J, et al. CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia. J Hematol Oncol. 2014;7:66 pubmed publisher
    ..Here, we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement that is associated with genes previously described as upregulated ..
  46. Islam M, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, et al. Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015;244:488-96 pubmed publisher
    ..Core binding factor β (Cbfb) is a cotranscription factor which forms a heterodimer with Runx proteins...
  47. Eisfeld A, Kohlschmidt J, Schwind S, Nicolet D, Blachly J, Orwick S, et al. Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia. Leukemia. 2017;31:1278-1285 pubmed publisher
    ..1q22)/t(16;16)(p13.1;q22)/CBFB-MYH11. The resulting fusion genes require a 'second hit' to initiate leukemogenesis...
  48. Chen X, Chen Z, Yu S, Nie F, Yan S, Ma P, et al. Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer. Clin Cancer Res. 2018;24:2002-2014 pubmed publisher
    ..as a ceRNA for miR-204-5p, thereby leading to the derepression of its endogenous target core-binding factor β (CBFB)...
  49. Metzeler K, Bloomfield C. Clinical Relevance of RUNX1 and CBFB Alterations in Acute Myeloid Leukemia and Other Hematological Disorders. Adv Exp Med Biol. 2017;962:175-199 pubmed publisher
    ..first section, we discuss the prognostic implications of the core binding factor translocations RUNX1-RUNX1T1 and CBFB-MYH11 in AML patients...
  50. Zappasodi P, Marbello L, Borlenghi E, Fumagalli M, Bernardi M, Fracchiolla N, et al. Molecular remission at the end of treatment is a necessary goal for a good outcome in ELN favorable-risk acute myeloid leukemia: a real-life analysis on 201 patients by the Rete Ematologica Lombarda network. Ann Hematol. 2018;97:2107-2115 pubmed publisher
    ..14.9%), inv. (16)(p13q22) or t(16;16)(p13q22)/CBFB-MIH11 (35 pts., 17.4%), normal karyotype and mutated NPM1 and negative FLT3-ITD (116 pts., 57...
  51. Sun P, Song Y, Liu D, Liu G, Mao X, Dong B, et al. Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer. Sci Rep. 2018;8:13483 pubmed publisher
    ..were simultaneously up-regulated, and 9 TFs (SRE, FKHR, Angiotensinogen ANG-IRE, Pax2, CD28RC/NF-IL2B, HLF, CPE, CBFB and c-Ets-1) were down-regulated...
  52. Philipot O, Joliot V, Ait Mohamed O, Pellentz C, Robin P, Fritsch L, et al. The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. PLoS ONE. 2010;5:e9425 pubmed publisher
    Core Binding Factor or CBF is a transcription factor composed of two subunits, Runx1/AML-1 and CBF beta or CBFbeta. CBF was originally described as a regulator of hematopoiesis...
  53. Bäckström S, Wolf Watz M, Grundström C, Härd T, Grundström T, Sauer U. The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding. J Mol Biol. 2002;322:259-72 pubmed
    ..This suggests a regulatory mechanism of RUNX proteins through acidic amino acid residues provided by activation domains during cooperative interaction with other transcription factors. ..
  54. Hart S, Foroni L. Core binding factor genes and human leukemia. Haematologica. 2002;87:1307-23 pubmed
    The core binding factor (CBF) transcription complex, consisting of the interacting proteins RUNX1 and CBFb, is essential for normal hematopoiesis...
  55. Yang B, Wang S, Zeng J, Zhang Y, Ruan X, Han W, et al. Proteomic screening and identification of microRNA-128 targets in glioma cells. Proteomics. 2015;15:2602-17 pubmed publisher
    ..validated that 11 of 13 selected genes were potential targets of miR-128, and a mutagenesis experiment confirmed CBFB, CORO1C, GLTP, HnRNPF, and TROVE2 as the target genes...
  56. Wang S, Wang S, Li H, Sun G, Lyu S, Liu X, et al. SNP in pre-miR-1666 decreases mature miRNA expression and is associated with chicken performance. Genome. 2015;58:81-90 pubmed publisher
    ..using dual-luciferase report assay, we verified that miR-1666 could perform its function through targeting of the CBFB gene. In conclusion, the SNP in the precursor of miR-1666 could significantly reduce mature miR-1666 production...
  57. Xia L, Wu L, Bao J, Li Q, Chen X, Xia H, et al. Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway. Biochem Biophys Res Commun. 2018;503:385-390 pubmed publisher
    ..In our study, we investigated the role of circ-CBFB in CLL. We found that circ-CBFB was markedly overexpressed in CLL cells compared to normal controls...
  58. He R, Wiktor A, Hanson C, Ketterling R, Kurtin P, Van Dyke D, et al. Conventional karyotyping and fluorescence in situ hybridization: an effective utilization strategy in diagnostic adult acute myeloid leukemia. Am J Clin Pathol. 2015;143:873-8 pubmed publisher
    ..FISH lent prognostic information in one (0.5%) of 220 cases with normal karyotype/abnormal FISH: CBFB-MYH11 fusion, indicating favorable prognosis...
  59. Ouyang J, Goswami M, Peng J, Zuo Z, Daver N, Borthakur G, et al. Comparison of Multiparameter Flow Cytometry Immunophenotypic Analysis and Quantitative RT-PCR for the Detection of Minimal Residual Disease of Core Binding Factor Acute Myeloid Leukemia. Am J Clin Pathol. 2016;145:769-77 pubmed publisher
    ..We studied 42 patients with t(8;21)(q22;q22)/RUNX1-RUNX1T1 and 51 with inv(16)(p13.1q22)/CBFB-MYH11 Tandem MRD analyses by MFC and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were ..
  60. Xue L, Pulikkan J, Valk P, Castilla L. NrasG12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbf?-SMMHC via activation of MEK/ERK axis. Blood. 2014;124:426-36 pubmed publisher
    ..Here, we used Nras(LSL-G12D); Cbfb(56M) knock-in mice to show that allelic expression of oncogenic Nras(G12D) and Cbf?-SMMHC increases survival of ..
  61. Wang J, Papanicolau Sengos A, Chintala S, Wei L, Liu B, Hu Q, et al. Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation. Oncotarget. 2016;7:29901-15 pubmed publisher
    ..F407C) in 2 samples. We identified somatic SNVs in 14 other cancer census genes including: ATM, CREBBP, PRDM1, CBFB, FBXW7, IKZF1, KDR, KRAS, NACA, NF2, NUP98, SS18, TP53, and ZNF521...
  62. Yoshikawa R, Izumi T, Nakano Y, Yamada E, Moriwaki M, Misawa N, et al. Small ruminant lentiviral Vif proteins commonly utilize cyclophilin A, an evolutionarily and structurally conserved protein, to degrade ovine and caprine APOBEC3 proteins. Microbiol Immunol. 2016;60:427-36 pubmed publisher
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    ..Thus, we identified a novel mechanism of protein regulation that affects both viral and cellular factors and thus has broad implications beyond the immediate HIV field. ..
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    ..NGF signals through the ERK/MAPK pathway to promote expression of Cbfb but not Runx1 prior to maturation of nonpeptidergic nociceptors...
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    ..We examined the expression of 3 Runt-related (RUNX) genes, RUNX1, RUNX2 and CBFB, in gastric cancer cell lines and primary gastric cancer specimens and compared them to those of RUNX3 reported ..
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    ..Altogether, our study identified p32 as a novel and specific corepressor of CBF-mediated transcription activation in vitro. ..
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    ..and core binding factor ß-smooth muscle myosin heavy chain (CBFß-SMMHC) (encoded by the inv(16) chimeric gene CBFB-MYH11) in inducing acute leukemia, and tested the sensitivity of FLT3-N676K-positive leukemic cells to FLT3 ..
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    ..8%), a frequency similar to CBFB-MYH11 fusion gene (4.0%). The most frequent NUP98 fusion gene partner is NSD1...
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    ..Further analysis and functional validation identified MBD2, CBFB, and HIF1A as downstream regulators of BMP4 signaling...
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    ..Whereas Cbfa-1, one of the three alpha subunits in the family, is essential for osteogenesis, Cbfb, the only beta subunit, forms heterodimers with different Cbfas to increase their DNA binding affinity by inducing ..
  82. Andersen C, Christensen L, Thorsen K, Schepeler T, Sørensen F, Verspaget H, et al. Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer. Br J Cancer. 2009;100:511-23 pubmed publisher
    ..stage I-III adenocarcinomas, by immunohistochemistry, revealed that patients with tumours displaying high levels of CBFB and SMARCC1 proteins had a significantly better overall survival rate (P=0.0001 and P=0...
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    ..Using a mouse genetic model, we also showed that the combined loss of Runx1/Cbfb inhibited leukemia development induced by MLL-AF9. RUNX2 could compensate for the loss of RUNX1...
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    ..Taken together, we propose a novel Vif N-terminal motif that is responsible for Vif recruitment of Cul5. Motifs in Vif that are absent from cellular proteins represent attractive targets for future HIV pharmaceutical design. ..
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    ..These results suggest that a different mechanism exists for the Vif-APOBEC interaction and that non-primates are not suitable animal models for exploring pharmacological interventions that disrupt Vif-CBF-β interaction. ..
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    ..we analyzed both pediatric (n = 87) and adult (n = 78) samples, including cases with RUNX1-RUNX1T1 (n = 85) or CBFB-MYH11 (n = 80) rearrangements, by whole-genome or whole-exome sequencing...
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    ..We recently showed that the combined loss of Runx1/Cbfb inhibited the development of MLL-AF9-induced AML...
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    ..This result clearly demonstrates that the Runx /Cbfb signaling pathway is indispensable in the development of the GCTs...
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    ..Taken together, these data indicate that acetylation of AML1 through p300 is a critical manner of posttranslational modification and identify a novel mechanism for regulating the function of AML1. ..
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    ..and transcriptome assembly revealed altered expression of more than 200 mRNA transcripts in the granulosa cells of Cbfb knockdown mice after human chorionic gonadotropin stimulation in vitro...
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    ..More importantly, knockdown of PRMT1 suppresses the self-renewal capability of AE9a, suggesting a potential role of PRMT1 in regulating leukemia development. ..