caveolin-2

Summary

Gene Symbol: caveolin-2
Description: caveolin 2
Alias: CAV, caveolin-2, caveolae protein, 20-kD, caveolin 2 isoform a and b
Species: human
Products:     caveolin-2

Top Publications

  1. Thorleifsson G, Walters G, Hewitt A, Masson G, Helgason A, Dewan A, et al. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma. Nat Genet. 2010;42:906-9 pubmed publisher
    ..42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG. ..
  2. Scherer P, Lewis R, Volonte D, Engelman J, Galbiati F, Couet J, et al. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J Biol Chem. 1997;272:29337-46 pubmed
    ..These results suggest that expression levels of caveolins 1, 2, and 3 can be independently up-regulated or down-regulated in response to a variety of distinct cellular cues. ..
  3. Ando T, Ishiguro H, Kimura M, Mitsui A, Mori Y, Sugito N, et al. The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma. Oncol Rep. 2007;18:601-9 pubmed
    ..0105 and 0.0424 for CAV1 and CAV2, respectively). These results suggest that positive staining for CAV1 and CAV2 could be a potentially useful prognostic marker of ESCC. ..
  4. Mora R, Bonilha V, Marmorstein A, Scherer P, Brown D, Lisanti M, et al. Caveolin-2 localizes to the golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1. J Biol Chem. 1999;274:25708-17 pubmed
  5. Savage K, Leung S, Todd S, Brown L, Jones R, Robertson D, et al. Distribution and significance of caveolin 2 expression in normal breast and invasive breast cancer: an immunofluorescence and immunohistochemical analysis. Breast Cancer Res Treat. 2008;110:245-56 pubmed
    The aims of this study were to define the distribution of caveolin 2 (CAV2) in frozen and formalin fixed, paraffin embedded (FFPE) normal breast samples and the significance of CAV2 expression in breast cancer...
  6. Pfeufer A, van Noord C, Marciante K, Arking D, Larson M, Smith A, et al. Genome-wide association study of PR interval. Nat Genet. 2010;42:153-9 pubmed publisher
    ..0056). This suggests a role for common variation in ion channel and developmental genes in atrial and atrioventricular conduction as well as in susceptibility to atrial fibrillation. ..
  7. Berta A, Kiss A, Kemeny Beke A, Lukats A, Szabó A, Szel A. Different caveolin isoforms in the retina of melanoma malignum affected human eye. Mol Vis. 2007;13:881-6 pubmed
    ..Since the retina contains a number of different neuronal and glial cell types, the caveolin expression of these cells can no longer be a matter of dispute. ..
  8. Fisher E, Schreiber S, Joost H, Boeing H, Döring F. A two-step association study identifies CAV2 rs2270188 single nucleotide polymorphism interaction with fat intake in type 2 diabetes risk. J Nutr. 2011;141:177-81 pubmed publisher
    ..An increase in dietary SFA from 10 to 20 % energy predicted an ~200% greater risk of type 2 diabetes. We found preliminary evidence that CAV2 rs2270188 interacts with dietary fat to affect risk of type 2 diabetes. ..
  9. Thangavel C, Gomes C, Zderic S, Javed E, Addya S, Singh J, et al. NF-κB and GATA-Binding Factor 6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy. Am J Pathol. 2019;189:847-867 pubmed publisher
    ..Loss of CAV protein expression is associated with impaired contraction in obstruction-induced bladder smooth muscle (BSM) ..

More Information

Publications137 found, 100 shown here

  1. Codenotti S, Vezzoli M, Poliani P, Cominelli M, Bono F, Kabbout H, et al. Caveolin-1, Caveolin-2 and Cavin-1 are strong predictors of adipogenic differentiation in human tumors and cell lines of liposarcoma. Eur J Cell Biol. 2016;95:252-64 pubmed publisher
    Caveolins (Cav-1, -2 and -3) and Cavins (Cavin-1, -2, -3 and -4) are two protein families controlling the biogenesis and function of caveolae, plasma membrane omega-like invaginations representing the primary site of important cellular ..
  2. Flick M, Albrecht M, Oei G, Steenstra R, Kerindongo R, Zuurbier C, et al. Helium postconditioning regulates expression of caveolin-1 and -3 and induces RISK pathway activation after ischaemia/reperfusion in cardiac tissue of rats. Eur J Pharmacol. 2016;791:718-725 pubmed publisher
    ..We hypothesize that HePoc regulates caveolin-1 and caveolin-3 (Cav-1 and Cav-3) expression in the rat heart and activates the RISK pathway...
  3. Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, et al. Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes. Biochem J. 2009;424:399-410 pubmed publisher
    ..siRNA (small interfering RNA)-mediated KD (knockdown) of CAV-1 (caveolin-1) in 3T3-L1 adipocytes resulted in down-regulation of expression of membrane-associated PDE3B...
  4. Horikawa Y, Panneerselvam M, Kawaraguchi Y, Tsutsumi Y, Ali S, Balijepalli R, et al. Cardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling. J Am Coll Cardiol. 2011;57:2273-83 pubmed publisher
    We hypothesized that cardiac myocyte-specific overexpression of caveolin-3 (Cav-3), a muscle-specific caveolin, would alter natriuretic peptide signaling and attenuate cardiac hypertrophy...
  5. Choi K, Kim H, Park M, Lee E, Lee J, Kim J, et al. Overexpression of caveolin-1 attenuates brain edema by inhibiting tight junction degradation. Oncotarget. 2016;7:67857-67867 pubmed publisher
    ..Caveolins (Cavs) are thought to regulate BBB functions. Here, we report for the first time that Cav-1 overexpression (OE) decreased brain edema from BBB disruption following ischemic insult...
  6. Atis M, Akcan U, Ugur Yilmaz C, Orhan N, Düzgün P, Deniz Ceylan U, et al. Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in angiotensin II-induced hypertensive rats. Brain Res. 2019;: pubmed publisher
    ..Immunohistochemistry for caveolin (Cav)-1 and tight junction protein claudin-5 was performed...
  7. Yokomori H, Ando W, Oda M. Caveolin-1 is related to lipid droplet formation in hepatic stellate cells in human liver. Acta Histochem. 2019;121:113-118 pubmed publisher
    ..Herein, we attempted to elucidate the ultrastructural localization and expression of caveolin-1 (CAV-1) in human HSCs during the progression of liver cirrhosis (LC)...
  8. Hirama T, Das R, Yang Y, Ferguson C, Won A, Yip C, et al. Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane. J Biol Chem. 2017;292:14292-14307 pubmed publisher
    ..We conclude that the predominant plasmalemmal anionic lipid PtdSer is essential for proper Cav clustering, caveola formation, and caveola dynamics and that membrane scrambling can perturb caveolar stability.
  9. Bai Y, Wu J, Li D, Morgan E, Liu J, Zhao X, et al. Differential roles of caveolin-1 in ouabain-induced Na+/K+-ATPase cardiac signaling and contractility. Physiol Genomics. 2016;48:739-748 pubmed publisher
    ..study is to compare ouabain-induced cardiac signaling and contractility in wild-type (WT) and caveolin-1 knockout (cav-1 KO) mice. In contrast with WT cardiomyocytes, ouabain-induced signaling e.g...
  10. Lee Y, Yoon S, Park C, Lee J, Lee Z, Kim H. Caveolin-1 regulates osteoclastogenesis and bone metabolism in a sex-dependent manner. J Biol Chem. 2015;290:6522-30 pubmed publisher
    ..Here, we show that caveolin-1 (Cav-1) plays a crucial role in the regulation of osteoclastogenesis...
  11. See Hoe L, Schilling J, Tarbit E, Kiessling C, Busija A, Niesman I, et al. Sarcolemmal cholesterol and caveolin-3 dependence of cardiac function, ischemic tolerance, and opioidergic cardioprotection. Am J Physiol Heart Circ Physiol. 2014;307:H895-903 pubmed publisher
    ..depletion with methyl-β-cyclodextrin (MβCD) and lifelong knockout (KO) or overexpression (OE) of caveolin-3 (Cav-3) on cardiac function, I/R tolerance, and opioid receptor (OR)-mediated protection...
  12. Parker S, Walker D, Ly S, Baylis H. Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans. Mol Biol Cell. 2009;20:1763-71 pubmed publisher
    ..Caenorhabditis elegans encodes two caveolin genes, cav-1 and cav-2...
  13. Santos M, Moura L, Mendes M, Arcanjo D, Monção N, Araújo B, et al. Hypotensive and vasorelaxant effects induced by the ethanolic extract of the Mimosa caesalpiniifolia Benth. (Mimosaceae) inflorescences in normotensive rats. J Ethnopharmacol. 2015;164:120-8 pubmed publisher
    ..In contractions induced by S(-)Bay K 8644, a Cav-L activator, the MC-EtOH/flowers promoted concentration-dependent relaxation, corroborating previous results...
  14. Hong K, Yu Z, Sun X, Wu C, Weng P, Wei M, et al. [Effect of caveolin-1 scaffolding domain peptides on heme oxygenase-1 activity increasing and M1/M2 phenotype polarization in rat alveolar macrophages induced by lipopolysaccharide]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:855-860 pubmed publisher
    ..After treatment for 16 hours, the co-localization between caveolin-1 (Cav-1) and HO-1 was displayed by confocal microscope; the mRNA expressions of inflammatory cytokines interleukin-1β (..
  15. Yang Y, Ma Z, Hu W, Wang D, Jiang S, Fan C, et al. Caveolin-1/-3: therapeutic targets for myocardial ischemia/reperfusion injury. Basic Res Cardiol. 2016;111:45 pubmed publisher
    ..Caveolae, caveolin-1 (Cav-1), and caveolin-3 (Cav-3) are essential for the protective effects of conditioning against myocardial I/R injury...
  16. Busija A, Patel H, Insel P. Caveolins and cavins in the trafficking, maturation, and degradation of caveolae: implications for cell physiology. Am J Physiol Cell Physiol. 2017;312:C459-C477 pubmed publisher
    ..including signal transduction effects, can destabilize caveolae and produce cavin dissociation, restructuring of Cav oligomers, ubiquitination, internalization, and degradation...
  17. Arza P, Netti V, Perosi F, Cernadas G, Ochoa F, Magnani N, et al. Involvement of nitric oxide and caveolins in the age-associated functional and structural changes in a heart under osmotic stress. Biomed Pharmacother. 2015;69:380-7 pubmed publisher
    ..whether a controlled water restriction of 1 month affects cardiac function, NO synthase (NOS) activity and NOS, and cav-1 and -3 protein levels in rats during aging...
  18. Lee Y, Yoon S, Ji E, Kim H. Caveolin-1 regulates osteoclast differentiation by suppressing cFms degradation. Exp Mol Med. 2015;47:e192 pubmed publisher
    ..In a microarray analysis, we found that caveolin-1 (Cav-1) was upregulated by receptor activator of NFκB ligand (RANKL), the osteoclast differentiation factor...
  19. Martínez N, Ayala A, Martinez M, Martínez Rivera F, Miranda J, SILVA W. Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells. J Biol Chem. 2016;291:12208-22 pubmed publisher
    ..Hence, this study evaluated the role of caveolin-1 (Cav-1) in modulating P2Y2R subcellular distribution and signaling in human 1321N1 astrocytoma cells...
  20. Su W, Zhang Y, Zhang Q, Xu J, Zhan L, Zhu Q, et al. N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats. Cardiovasc Diabetol. 2016;15:146 pubmed
    ..Caveolae are critical in the transduction of eNOS/NO signaling in cardiovascular system. Caveolin (Cav)-3, the cardiomyocytes-specific caveolae structural protein, is decreased in the diabetic heart in which production ..
  21. Podemska Jedrzejczak Z, Malinska A, Sujka Kordowska P, Nowicki M, Puślecki M, Jemielity M, et al. Vascular restenosis in coronary artery bypass grafting might be associated with VEGF-C/VEGFR-3 signaling pathway. Heart Vessels. 2018;33:1106-1120 pubmed publisher
    ..CAV2 protein expression in SMCs of ITA grafts indicated the risk of early graft failure both in double-vessel and triple-vessel CAD subjects. ..
  22. Labarrere C, Jaeger B, Kassab G. Cardiac allograft vasculopathy: Microvascular arteriolar capillaries ('capioles") and survival. Front Biosci (Elite Ed). 2017;9:110-128 pubmed
    Cardiac allograft vasculopathy (CAV) is a serious complication of heart transplantation in adults and children...
  23. Sohn J, Lin H, Fritch M, Tuan R. Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells. Stem Cell Res Ther. 2018;9:86 pubmed publisher
    ..In this study, we examined the effects of perturbations in cholesterol/caveolin-1 (CAV-1)/caveolae homeostasis on the membrane properties and adhesive characteristics of MSCs...
  24. Wang W, Gu L, Verkhratsky A, Peng L. Ammonium Increases TRPC1 Expression Via Cav-1/PTEN/AKT/GSK3? Pathway. Neurochem Res. 2017;42:762-776 pubmed publisher
    ..We have studied the involvement of Cav-1/PTEN/AKT/GSK-3? signalling system in regulation of TRPC1 gene expression by ammonium...
  25. Zhu B, Rippe C, Thi Hien T, Zeng J, Albinsson S, Stenkula K, et al. Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle. PLoS ONE. 2017;12:e0176759 pubmed publisher
    ..In all, these findings further support the view that myocardin family coactivators are important transcriptional drivers of caveolins and cavins in smooth muscle. ..
  26. Smit K, Konkel M, Kerindongo R, Landau M, Zuurbier C, Hollmann M, et al. Helium alters the cytoskeleton and decreases permeability in endothelial cells cultured in vitro through a pathway involving Caveolin-1. Sci Rep. 2018;8:4768 pubmed publisher
    ..We hypothesised that helium might affect the cytoskeleton and induce secretion of Caveolin. HCAEC, HUVEC and Cav-1 siRNA transfected HUVEC were exposed for 20 minutes to either helium (5% CO2, 25% O2,..
  27. Tran C, Stary C, Schilling J, Bentley B, Patel H, Roth D. Role of caveolin-3 in lymphocyte activation. Life Sci. 2015;121:35-9 pubmed publisher
    ..While caveolin-1 (Cav-1) has been shown to regulate lymphocyte activation, the role of caveolin-3 (Cav-3) in immune system signaling has ..
  28. Netti V, Iovane A, Vatrella M, Magnani N, Evelson P, Zotta E, et al. Dehydration affects cardiovascular nitric oxide synthases and caveolins in growing rats. Eur J Nutr. 2016;55:33-43 pubmed publisher
    During the postnatal stage, cardiovascular nitric oxide (NO) system and caveolins (cav) may be regulated differentially in response to hypovolemic state induced by water restriction...
  29. Razani B, Lisanti M. Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. Am J Physiol Cell Physiol. 2001;281:C1241-50 pubmed
    ..gain mechanistic insights into these processes in vivo, we have assessed the functional interaction of caveolin-1 (Cav-1) with PKA using mutational analysis...
  30. Monti M, Ciccone V, Pacini A, Roggeri R, Monzani E, Casella L, et al. Anti-hypertensive property of a nickel-piperazine/NO donor in spontaneously hypertensive rats. Pharmacol Res. 2016;107:352-359 pubmed publisher
    ..by upregulating endothelial NO synthase (eNOS) through increased eNOS protein levels and downregulated Caveolin-1 (Cav-1), and by increasing superoxide dismutase 1 (SOD1) protein level in aortae...
  31. Nakada Y, Yamamoto I, Horita S, Kobayashi A, Mafune A, Katsumata H, et al. The prognostic values of caveolin-1 immunoreactivity in peritubular capillaries in patients with kidney transplantation. Clin Transplant. 2016;30:1417-1424 pubmed publisher
    ..We previously showed that the ENDAT caveolin-1 (CAV-1) is a distinct feature of CAAMR...
  32. Waraczynski M, Abbott S, Schultz A. CaV1.3 channel blockade in the extended amygdala has a delayed effect on the reward efficacy of medial forebrain bundle stimulation. Behav Brain Res. 2017;317:485-493 pubmed publisher
    ..affect the activity status of SLEAc neurons is by indirectly blocking calcium ion (Ca2+) influx through CaV1.3 channels. He we directly investigate the effects of blocking CaV1...
  33. Motloch L, Larbig R, Darabi T, Reda S, Motloch K, Wernly B, et al. Long-QT syndrome-associated caveolin-3 mutations differentially regulate the hyperpolarization-activated cyclic nucleotide gated channel 4. Physiol Int. 2017;104:130-138 pubmed publisher
    Background Caveolin-3 (cav-3) mutations are linked to the long-QT syndrome (LQTS) causing distinct clinical symptoms. Hyperpolarization-activated cyclic nucleotide channel 4 (HCN4) underlies the pacemaker current If...
  34. Rahman W, Patel R, Dickenson A. Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis. Neuroscience. 2015;305:76-85 pubmed publisher
    ..Our in vivo electrophysiological results demonstrate a pathological state-dependent effect of TROX-1, which suggests an increased functional role of Cav2, likely Cav2.2, channels in mediating OA pain. ..
  35. Muir R, Ballan J, Clifford B, McMullen S, Khan R, Shmygol A, et al. Modelling maternal obesity: the effects of a chronic high-fat, high-cholesterol diet on uterine expression of contractile-associated proteins and ex vivo contractile activity during labour in the rat. Clin Sci (Lond). 2016;130:183-92 pubmed publisher
    ..concentrations and collection of myometrium for contractility studies and expression of CAPs caveolin-1 (Cav-1), connexin-43 (CX-43) and it's phosphorylated form (pCX-43), oxytocin receptor (OXTR) and cyclooxygenase-2 (COX-2)..
  36. Kowalska K, Nowakowska M, Domińska K, Piastowska Ciesielska A. Coexpression of CAV-1, AT1-R and FOXM1 in prostate and breast cancer and normal cell lines and their influence on metastatic properties. Acta Biochim Pol. 2016;63:493-9 pubmed publisher
    The aim of this study was to evaluate the coexpression of caveolin-1 (CAV-1), angiotensin II type 1 receptor (AT1-R) and forkhead box Ml (FOXM1) in prostate and breast cancer cell lines, in comparison with normal cell lines...
  37. Dahimene S, Page K, Nieto Rostro M, Pratt W, D Arco M, Dolphin A. A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant. Neurobiol Dis. 2016;93:243-56 pubmed publisher
    ..1, which prevents the correct folding of the wild-type channel. In agreement with this, we were able to disrupt the interaction between EA2 and the full length channel by co-expressing a free N-terminal peptide. ..
  38. Collaço R, Randazzo Moura P, Tamascia M, da Silva I, Rocha T, Cogo J, et al. Bothrops fonsecai snake venom activities and cross-reactivity with commercial bothropic venom. Comp Biochem Physiol C Toxicol Pharmacol. 2017;191:86-100 pubmed publisher
    ..a pitviper endemic to southeastern Brazil, and assessed their neutralization by commercial bothropic antivenom (CAv)...
  39. Ulrich S, Lehner A, Birnbaum J, Heckel S, Haas N, Hakami L, et al. Safety of optical coherence tomography in pediatric heart transplant patients. Int J Cardiol. 2017;228:205-208 pubmed publisher
    Cardiac allograft vasculopathy (CAV) is a crucial problem after heart transplantation, in adults as well as in children. CAV is the main risk factor for a reduced long-term graft survival...
  40. Dombert B, Balk S, Lüningschrör P, Moradi M, Sivadasan R, Saal Bauernschubert L, et al. BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on ?2-Chain Laminin (221). Front Mol Neurosci. 2017;10:346 pubmed publisher
    ..2 clustering and local calcium transients. These findings may help to explore cellular mechanisms which might be dysregulated during maturation of embryonic motoneurons leading to motoneuron disease...
  41. Polking M, Dibos A, de Leon N, Park H. Improving Defect-Based Quantum Emitters in Silicon Carbide via Inorganic Passivation. Adv Mater. 2017;: pubmed publisher
    ..Specifically, carbon antisite-vacancy pairs (CAV centers) in 4H-SiC, which serve as single-photon emitters at visible wavelengths, are used as a model system to ..
  42. Zhou Q, Ruan Z, Yuan H, Xu D, Zeng S. ABCB1 gene polymorphisms, ABCB1 haplotypes and ABCG2 c.421c > A are determinants of inter-subject variability in rosuvastatin pharmacokinetics. Pharmazie. 2013;68:129-34 pubmed
    ..impact of the aforementioned SNPs on steady state pharmacokinetic parameters [average steady state concentration (Cav,ss) and area under the plasma concentration versus time curve during the dosing interval at steady state (AUCss)], ..
  43. Goedicke Fritz S, Kaistha A, Kacik M, Markert S, Hofmeister A, Busch C, et al. Evidence for functional and dynamic microcompartmentation of Cav-1/TRPV4/K(Ca) in caveolae of endothelial cells. Eur J Cell Biol. 2015;94:391-400 pubmed publisher
    ..1 with Cav-1 and TRPV4...
  44. Juhas M, Ajioka J. Integrative bacterial artificial chromosomes for DNA integration into the Bacillus subtilis chromosome. J Microbiol Methods. 2016;125:1-7 pubmed publisher
    ..subtilis chromosome. The engineered integrative bacterial artificial chromosome iBAC(cav) can accept any DNA fragment for integration into B...
  45. Moriyama T, Sasaki K, Karasawa K, Uchida K, Nitta K. Intracellular transcytosis of albumin in glomerular endothelial cells after endocytosis through caveolae. J Cell Physiol. 2017;232:3565-3573 pubmed publisher
    ..MBCD also decreased albuminuria, causing decreased caveolin-1 (Cav-1) expression on glomerular capillaries, in puromycin aminonucleoside induced nephrotic mice...
  46. Egawa J, Zemljic Harpf A, Mandyam C, Niesman I, Lysenko L, Kleschevnikov A, et al. Neuron-Targeted Caveolin-1 Promotes Ultrastructural and Functional Hippocampal Synaptic Plasticity. Cereb Cortex. 2017;:1-12 pubmed publisher
    ..Immunogold electron microscopy revealed that Cav-1 localizes to both the pre- and postsynaptic membrane regions as well as in the synaptic cleft...
  47. Fang W, Ruan W, Lin S, Chen Y, Zhu K. Caveolin-1 in multi drug resistance and two-field lymphadenectomy for thoracic esophageal squamous cell carcinoma. Pak J Pharm Sci. 2017;30:1857-1866 pubmed
    ..In this paper, we studied the relationship between Cav-1 and other multi drug resistance associated proteins...
  48. Kwon H, Jang D, Choi M, Lee J, Jeong K, Pak Y. Alternative translation initiation of Caveolin-2 desensitizes insulin signaling through dephosphorylation of insulin receptor by PTP1B and causes insulin resistance. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2169-2182 pubmed publisher
    ..Here we show that alternative translation initiation (ATI) of Caveolin-2 (Cav-2) regulates insulin sensitivity...
  49. Sando G, Zhu H, Weis J, Richman J, Wertz P, Madison K. Caveolin expression and localization in human keratinocytes suggest a role in lamellar granule biogenesis. J Invest Dermatol. 2003;120:531-41 pubmed
  50. Turek M, Biczak R, Pawłowska B, Różycka Sokołowska E, Marciniak B, Deska M, et al. Ammonium haloacetates - An alternative to glyphosate?. Chemosphere. 2018;194:650-656 pubmed publisher
    ..herbicidal activity was investigated in relation to popular weeds species gallant soldier (Galinsoga parviflora Cav.) and common sorrel (Rumex acetosa L.)...
  51. Canale F, Dávila S, Sasso C, Pellarín N, Mattar Domínguez M. Immunization with Larrea divaricata Cav. proteins elicits opsonic antibodies against Pseudomonas aeruginosa and induces phagocytic activity of murine macrophages. Microb Pathog. 2018;118:257-267 pubmed publisher
    ..Larrea divaricata Cav. (Jarilla) is a widely spread plant in America and it is used in folk medicine to treat several pathologies...
  52. Lin S, Nadeau P, Mergia A. HIV inhibits endothelial reverse cholesterol transport through impacting subcellular Caveolin-1 trafficking. Retrovirology. 2015;12:62 pubmed publisher
    ..approach, we demonstrated that exposure of HAECs to HIV infected cells or Nef alone disrupts caveolin 1 (Cav-1) subcellular trafficking upon HDL stimulation...
  53. Lowette K, Desmet A, Farré R, Tack J, Vanden Berghe P. Fructose consumption impairs serotonergic signaling in the murine enteric nervous system. Neurogastroenterol Motil. 2016;28:1438-42 pubmed publisher
    ..Expression of synaptobrevin CaV 2.1 and CaV 2.2 mRNA did not differ after fructose intake; however, CaV 2...
  54. Haeseleer F, Williams B, Lee A. Characterization of C-terminal Splice Variants of Cav1.4 Ca2+ Channels in Human Retina. J Biol Chem. 2016;291:15663-73 pubmed publisher
    Voltage-gated Ca(2+) channels (Cav) undergo extensive alternative splicing that greatly enhances their functional diversity in excitable cells. Here, we characterized novel splice variants of the cytoplasmic C-terminal domain of Cav1...
  55. Uehiro N, Sato F, Pu F, Tanaka S, Kawashima M, Kawaguchi K, et al. Circulating cell-free DNA-based epigenetic assay can detect early breast cancer. Breast Cancer Res. 2016;18:129 pubmed
    ..As detection of early BC using this system was comparable with that of mammography screening, this system would be beneficial as an optional method of screening for BC. ..
  56. Hirano M, Takada Y, Wong C, Yamaguchi K, Kotani H, Kurokawa T, et al. C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 ?1 subunits are differentially regulated by Rab3-interacting molecule proteins. J Biol Chem. 2017;292:9365-9381 pubmed publisher
    ..These results suggest that the interactions of the CaV2.1 CTD with RIMs enable CaV2.1 proteins to distinguish ?-RIM isoforms in VDI suppression of P/Q-type VDCC currents. ..
  57. Cerri M, Sapkota R, Coppi A, Ferri V, Foggi B, Gigante D, et al. Oomycete Communities Associated with Reed Die-Back Syndrome. Front Plant Sci. 2017;8:1550 pubmed publisher
    i>Phragmites australis (Cav.) Trin. ex Steud. die-back is a widely-studied phenomenon that was first discovered in northern Europe and that, until recently, was almost unknown in the Mediterranean basin...
  58. Hussein A, Scholz M. Treatment of artificial wastewater containing two azo textile dyes by vertical-flow constructed wetlands. Environ Sci Pollut Res Int. 2018;25:6870-6889 pubmed publisher
    ..to laboratory-scale vertical-flow construction wetland systems, which have been planted with Phragmites australis (Cav.) Trin. ex Steud. (common reed)...
  59. Wu B, Geng S, Bi Y, Liu H, Hu Y, Li X, et al. Herpes Simplex Virus 1 Suppresses the Function of Lung Dendritic Cells via Caveolin-1. Clin Vaccine Immunol. 2015;22:883-95 pubmed publisher
    Caveolin-1 (Cav-1), the principal structural protein of caveolae, has been implicated as a regulator of virus-host interactions. Several viruses exploit caveolae to facilitate viral infections...
  60. Forrester S, Elliott K, Kawai T, Obama T, Boyer M, Preston K, et al. Caveolin-1 Deletion Prevents Hypertensive Vascular Remodeling Induced by Angiotensin II. Hypertension. 2017;69:79-86 pubmed
    ..Cav1-/- and control Cav+/+ mice were infused with AngII for 2 weeks to induce vascular remodeling and hypertension...
  61. Park S, Shin K, Park H, Yoou S, Park J, Kang Y, et al. Caveolar remodeling is a critical mechanotransduction mechanism of the stretch-induced L-type Ca2+ channel activation in vascular myocytes. Pflugers Arch. 2017;469:829-842 pubmed publisher
    ..by methyl-β-cychlodextrin (MβCD) similarly disrupted the caveolae structure and translocated caveolin-1 (Cav-1) from membrane to cytosolic space. Accordingly, MβCD also increased VDCCL currents...
  62. Gnanaraj C, Shah M, Song T, Iqbal M. Hepatoprotective mechanism of Lygodium microphyllum (Cav.) R.Br. through ultrastructural signaling prevention against carbon tetrachloride (CCl4)-mediated oxidative stress. Biomed Pharmacother. 2017;92:1010-1022 pubmed publisher
    Plants have been consumed in medicinal practices for centuries. Lygodium microphyllum (Cav.) R.Br...
  63. Rousset M, Cens T, Menard C, Bowerman M, Bellis M, Brusés J, et al. Regulation of neuronal high-voltage activated Ca(V)2 Ca(2+) channels by the small GTPase RhoA. Neuropharmacology. 2015;97:201-9 pubmed publisher
    ..1, CaV2.2 and CaV2.3 Ca(2+) channels independently of CaVβ subunit...
  64. Yang H, Guan L, Li S, Jiang Y, Xiong N, Li L, et al. Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo. Oncotarget. 2016;7:16227-47 pubmed publisher
    Cancer cells are subjected to fluid shear stress during passage through the venous and lymphatic system. Caveolin-1 (Cav-1), a principal structural component of caveolar membrane domains, contributes to cancer development but its ..
  65. Shulman L, Davidson I. Viruses with Circular Single-Stranded DNA Genomes Are Everywhere!. Annu Rev Virol. 2017;4:159-180 pubmed publisher
    ..The relatively recent emergence of single-stranded DNA viruses, such as chicken anemia virus (CAV) and porcine circovirus 2 (PCV2), as serious pathogens of eukaryotes is due more to growing awareness than to the ..
  66. Tremblay Gravel M, Racine N, de Denus S, Ducharme A, Pelletier G, Giraldeau G, et al. Changes in Outcomes of Cardiac Allograft Vasculopathy Over 30 Years Following Heart Transplantation. JACC Heart Fail. 2017;5:891-901 pubmed publisher
    This study investigated temporal changes in the demographics and the prognosis of cardiac allograft vasculopathy (CAV) over 30 years following heart transplantation (HTx)...
  67. Savalli N, Pantazis A, Sigg D, Weiss J, Neely A, Olcese R. The α2δ-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentials. J Gen Physiol. 2016;148:147-59 pubmed publisher
    Excitation-evoked calcium influx across cellular membranes is strictly controlled by voltage-gated calcium channels (CaV), which possess four distinct voltage-sensing domains (VSDs) that direct the opening of a central pore...
  68. García J, Prieto L, Guevara A, Malagon D, Osorio C. Chemical Studies of Yellow Tamarillo (Solanum betaceum Cav.) Fruit Flavor by Using a Molecular Sensory Approach. Molecules. 2016;21: pubmed publisher
    The odor-active volatile compounds of yellow tamarillo fruit (S. betaceum Cav.) were identified and quantified by using a sensomics approach, combining a gentle volatile extraction (solvent-assisted flavor evaporation (SAFE)), gas ..
  69. Idrees D, Kumar S, Rehman S, Gourinath S, Islam A, Ahmad F, et al. Cloning, expression, purification and characterization of human mitochondrial carbonic anhydrase VA. 3 Biotech. 2016;6:16 pubmed publisher
    ..b>CAV is primarily involved in several biosynthetic processes such as ureagenesis, gluconeogenesis and lipogenesis by ..
  70. Barakat A, Sperry B, Starling R, Mentias A, Popovic Z, Griffin B, et al. Prognostic Utility of Right Ventricular Free Wall Strain in Low Risk Patients After Orthotopic Heart Transplantation. Am J Cardiol. 2017;119:1890-1896 pubmed publisher
    ..14 years, 64% men) free of antibody-mediated rejection or moderate to severe coronary allograft vasculopathy (CAV, grade 2 to 3) at 1 year after transplant. LV-GLS and RV-FWS were calculated using EchoPAC software...
  71. Liao L, Zheng B, Yi B, Liu C, Chen L, Zeng Z, et al. Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome. Exp Cell Res. 2017;359:266-274 pubmed publisher
    ..The over-expression of Cav-1 resulted in the relocation of ANXA2 from caveolae and negatively regulated ERK1/2 and NF-?B activation, which ..
  72. Vecchia A, Rigotto C, Soliman M, Souza F, Giehl I, Spilki F. Recovery rate of multiple enteric viruses artificially seeded in water and concentrated by adsorption-elution with negatively charged membranes: interaction and interference between different virus species. Water Sci Technol. 2015;72:2291-300 pubmed publisher
    ..was conducted to assess viral recovery rates for viral species commonly found in water (HAdV-5, EV, RV, BAdV and CAV-2), quantifying viral genomes at the end of the five different steps of the process...
  73. Guihaire J, Noly P, Martin A, Rojo M, Aymami M, Ingels A, et al. Impact of donor comorbidities on heart transplant outcomes in the modern era. Interact Cardiovasc Thorac Surg. 2017;24:898-904 pubmed publisher
    ..The incidence of primary graft dysfunction (PGD) and cardiac allograft vasculopathy (CAV) and overall survival were compared in 2 groups of HTx recipients: those receiving transplants from 1996 to 2004 (..
  74. Chao W, Su C, Peng H, Chou S. Melaleuca quinquenervia essential oil inhibits ?-melanocyte-stimulating hormone-induced melanin production and oxidative stress in B16 melanoma cells. Phytomedicine. 2017;34:191-201 pubmed publisher
    ..The essential oil extracted from Melaleuca quinquenervia (Cav.) S.T. Blake (paperbark) (MQ-EO) has various functional properties...
  75. Monteleone S, Lieb A, Pinggera A, Negro G, Fuchs J, Hofer F, et al. Mechanisms Responsible for ?-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains. Biophys J. 2017;113:1485-1495 pubmed publisher
    ..Functional characterization validates the modeling prediction showing that CaV1.3-R990H channels conduct ?-currents at hyperpolarizing potentials, but not upon membrane depolarization compared with wild-type channels...
  76. Engelman J, Zhang X, Lisanti M. Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. FEBS Lett. 1998;436:403-10 pubmed
    ..Natl. Acad. Sci. USA 92, 1381-1385; Engelman, J.A. et al. (1997) J. Biol. Chem. 272, 16374-16381), we propose that the caveolin-1 gene may represent the candidate tumor suppressor gene at the D7S522 locus on human chromosome 7q31.1. ..
  77. Abulrob A, Giuseppin S, Andrade M, McDermid A, Moreno M, Stanimirovic D. Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae. Oncogene. 2004;23:6967-79 pubmed
    ..The evidence suggests that the phosphorylation-regulated sequestration of EGFR in caveolae may be involved in arresting constitutive or ligand-induced signaling through EGFR responsible for glial cell transformation. ..
  78. Abel B, Willoughby C, Jang S, Cooper L, Xie L, Vo Ransdell C, et al. N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells. FEBS Lett. 2012;586:3317-23 pubmed publisher
    Here we show that tyrosine phosphorylation of caveolin-2 (Cav-2) negatively regulates the anti-proliferative function of transforming growth factor beta (TGF-beta) in endothelial cells...
  79. Soares E, Mendonça M, da Cruz Höfling M. Caveolae as a target for Phoneutria nigriventer spider venom. Neurotoxicology. 2016;54:111-118 pubmed publisher
    ..plasma membrane that are rich in cholesterol, glycosphingolipids and the scaffolding protein Caveolina-1 (Cav-1)...
  80. Constantin C, Müller C, Leitner M, Bildl W, Schulte U, Oliver D, et al. Identification of Cav2-PKC? and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling. Proc Natl Acad Sci U S A. 2017;114:5707-5712 pubmed publisher
    Voltage-activated calcium (Cav) channels couple intracellular signaling pathways to membrane potential by providing Ca2+ ions as second messengers at sufficiently high concentrations to modulate effector proteins located in ..
  81. Hiromura M, Nohtomi K, Mori Y, Kataoka H, Sugano M, Ohnuma K, et al. Caveolin-1, a binding protein of CD26, is essential for the anti-inflammatory effects of dipeptidyl peptidase-4 inhibitors on human and mouse macrophages. Biochem Biophys Res Commun. 2018;495:223-229 pubmed publisher
    ..Caveolin-1 (Cav-1), a major structural protein of caveolae located on the surface of the cellular membrane, has been reported to ..
  82. Dibué Adjei M, Kamp M, Alpdogan S, Tevoufouet E, Neiss W, Hescheler J, et al. Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo. Cell Physiol Biochem. 2017;44:935-947 pubmed publisher
    ..This paradoxical mechanism, possibly reflecting rebound hyperexcitation of pyramidal CA1 neurons after increased inhibition, may be key in understanding LTG-induced seizure aggravation, observed in clinical practice. ..
  83. Fra A, Pasqualetto E, Mancini M, Sitia R. Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2. Gene. 2000;243:75-83 pubmed
    ..The corresponding genes in humans (CAV and CAV2, respectively), have been mapped to a common locus in chromosome 7q31...
  84. Burgermeister E, Tencer L, Liscovitch M. Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. Oncogene. 2003;22:3888-900 pubmed
    ..These findings may have potentially important functional implications in the context of cancer differentiation therapy and multidrug resistance. ..
  85. Sakagami H, Aoki J, Natori Y, Nishikawa K, Kakehi Y, Natori Y, et al. Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. J Biol Chem. 2005;280:23084-93 pubmed
    ..The present results suggest that NPP6 has a specific role through the hydrolysis of polyunsaturated LPC, glycerophosphorylcholine, or sphingosylphosphorylcholine in these organs. ..
  86. Lanciotti A, Brignone M, Camerini S, Serafini B, Macchia G, Raggi C, et al. MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation. Neurobiol Dis. 2010;37:581-95 pubmed publisher
    ..Because pathological mutations prevent MLC1 membrane expression, the identification of substances regulating MLC1 intracellular trafficking is potentially relevant for the therapy of MLC. ..
  87. Kwon H, Jeong K, Hwang E, Park J, Pak Y. A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J Cell Mol Med. 2011;15:888-908 pubmed publisher
    ..extracellular signal-regulated kinase (ERK) is translocated to the nuclear envelope by caveolin-2 (cav-2) and associates with lamin A/C in the inner nuclear membrane in response to insulin...
  88. Lee S, Kwon H, Jeong K, Pak Y. Regulation of cancer cell proliferation by caveolin-2 down-regulation and re-expression. Int J Oncol. 2011;38:1395-402 pubmed publisher
    We investigated whether altering caveolin-2 (cav-2) expression affects the proliferation of cancer cells...
  89. Jiang Y, Sverdlov M, Toth P, Huang L, Du G, Liu Y, et al. Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells. J Biol Chem. 2016;291:20729-38 pubmed publisher
    ..Caveolae-mediated endocytosis is activated by Src-dependent caveolin-1 (Cav-1) phosphorylation and subsequent recruitment of dynamin-2 and filamin A (FilA), which facilitate vesicle fission ..
  90. Lee J, Kang J, Ryu Y, Han S, Nam Y, Rho J, et al. Genetically engineered and self-assembled oncolytic protein nanoparticles for targeted cancer therapy. Biomaterials. 2017;120:22-31 pubmed publisher
    ..Apoptin from chicken anaemia virus (CAV) was used as a tumour-selective apoptotic protein...
  91. Yu D, Jung S, An H, Lee S, Hong J, Park J, et al. Caveolin-1 deficiency induces premature senescence with mitochondrial dysfunction. Aging Cell. 2017;16:773-784 pubmed publisher
    Paradoxical observations have been made regarding the role of caveolin-1 (Cav-1) during cellular senescence...
  92. Suantawee T, Elazab S, Hsu W, Yao S, Cheng H, Adisakwattana S. Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca2+ Channels. Nutrients. 2017;9: pubmed publisher
    ..2, and Cav1.2 genes...