CATSPER1

Summary

Gene Symbol: CATSPER1
Description: cation channel, sperm associated 1
Alias: CATSPER, SPGF7, cation channel sperm-associated protein 1, hCatSper, sperm ion channel, sperm-associated cation channel 1
Species: human

Top Publications

  1. ncbi A sperm ion channel required for sperm motility and male fertility
    D Ren
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 413:603-9. 2001
  2. pmc 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm
    Linda Lefievre
    Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Biochem J 448:189-200. 2012
  3. doi Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa
    V Sagare-Patil
    Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India
    Int J Androl 35:633-44. 2012
  4. doi A caged progesterone analog alters intracellular Ca2+ and flagellar bending in human sperm
    M Rocio Servin-Vences
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, Apdo Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Reproduction 144:101-9. 2012
  5. ncbi Ion channels in sperm physiology and male fertility and infertility
    Kamla Kant Shukla
    Division of Endocrinology, Central Drug Research Institute, Lucknow, UP, India
    J Androl 33:777-88. 2012
  6. pmc The CatSper channel: a polymodal chemosensor in human sperm
    Christoph Brenker
    Center of Advanced European Studies and Research caesar, Abteilung Molekulare Neurosensorik, Bonn, Germany
    EMBO J 31:1654-65. 2012
  7. doi Immunization of male mice with B-cell epitopes in transmembrane domains of CatSper1 inhibits fertility
    Honggang Li
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Fertil Steril 97:445-52. 2012
  8. doi The control of male fertility by spermatozoan ion channels
    Polina V Lishko
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 74:453-75. 2012
  9. pmc p,p'-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations
    Renata S Tavares
    Biology of Reproduction and Stem Cell Group, CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3001 401, Portugal
    Hum Reprod 28:3167-77. 2013
  10. doi A Chinese herbal decoction can increase the intracellular Ca2+ concentration and CatSper1 expression in mouse sperm tails
    Shaobo Luo
    Department of Andrology, Air Force General Hospital of PLA, Beijing 100142, PR China
    Mol Med Rep 7:195-200. 2013

Scientific Experts

  • Sarah D Olson
  • S S Suarez
  • Anna Lobley
  • Yuriy Kirichok
  • Shabnam Mohammadi
  • Chengyi Song
  • Lian Hu
  • Dejian Ren
  • Yuan yuan Yang
  • Timothy A Quill
  • Di Zhang
  • Xinjiang Cai
  • A Darszon
  • Susan H Benoff
  • Timo Strünker
  • David E Clapham
  • HARVEY FLORMAN
  • David Nelson
  • Betsy Navarro
  • Polina V Lishko
  • Jingsheng Xia
  • JAYHONG CHONG
  • Hong Gang Li
  • Gunda I Georg
  • Anne E Carlson
  • Wardah Alasmari
  • Christopher L R Barratt
  • Xu Hui Zeng
  • Sarah Costello
  • Honggang Li
  • Jackson Kirkman-Brown
  • Jennifer Morris
  • Stephen Publicover
  • Linda Lefievre
  • Michael S Hildebrand
  • Matthew R Avenarius
  • Jin Liu
  • Cheng Liang Xiong
  • Ai Hua Liao
  • Bertil Hille
  • Donner F Babcock
  • Renata S Tavares
  • Rashmi Bhilawadikar
  • Minerva Mata-Rocha
  • Shavahn C Loux
  • Deepak Modi
  • Senga K Oxenham
  • Vrushali Sagare-Patil
  • João Ramalho-Santos
  • Shaobo Luo
  • James F Smith
  • E Balderas
  • Stephen J Publicover
  • João Correia
  • Steven Mansell
  • Stuart M Wilson
  • Christopher J Lingle
  • Christoph Brenker
  • Xiao Ming Xia
  • V Sagare-Patil
  • Kamla Kant Shukla
  • M Rocio Servin-Vences
  • Mahboobeh Nazari
  • Catherine Serres
  • Marc Fellous
  • Wen Bin Wu
  • Francesco Michelangeli
  • Haixin Chang
  • Huangtao Guan
  • Chengliang Xiong
  • Katherine Nash
  • Xiaofang Ding
  • Zilong Sun
  • Shao Bo Luo
  • Jean Ju Chung
  • Nicole C Meyer
  • Richard J H Smith
  • Hossein Najmabadi
  • Kimia Kahrizi
  • Yuzhou Zhang
  • Haikun Wang
  • J Rezaian
  • Katharine Ho
  • Kwang Hyun Cho
  • Jayhong A Chong
  • Anuradha Dhingra
  • Yong Wang
  • Magdalene M Moran
  • Jingling Jin
  • Li juan Kong

Detail Information

Publications80

  1. ncbi A sperm ion channel required for sperm motility and male fertility
    D Ren
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 413:603-9. 2001
    ..Here we describe a putative sperm cation channel, CatSper, whose amino-acid sequence most closely resembles a single, six-transmembrane-spanning repeat of the voltage-..
  2. pmc 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm
    Linda Lefievre
    Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Biochem J 448:189-200. 2012
    ..In accordance with recent reports that progesterone directly activates CatSper, the [Ca2+]i transient was detectable in the anterior flagellum (where CatSper is expressed) 1-2 s before ..
  3. doi Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa
    V Sagare-Patil
    Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India
    Int J Androl 35:633-44. 2012
    ..concentration of progesterone is not absolutely dependent on activation of T-type voltage-gated Ca(2+) channel or CatSper as Mibefradil did not completely abrogate progesterone-mediated effects...
  4. doi A caged progesterone analog alters intracellular Ca2+ and flagellar bending in human sperm
    M Rocio Servin-Vences
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, Apdo Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Reproduction 144:101-9. 2012
    ..Our finding is mostly consistent with the recent discovery that progesterone activates CatSper channels in human spermatozoa, but not in mouse spermatozoa.
  5. ncbi Ion channels in sperm physiology and male fertility and infertility
    Kamla Kant Shukla
    Division of Endocrinology, Central Drug Research Institute, Lucknow, UP, India
    J Androl 33:777-88. 2012
    ..The presence of the sperm-associated cation channel (CatSper1-4) gene family, proton voltage-gated ion channel (Hv1), potassium voltage-gated ion channel (SLO3/KCNU1), ..
  6. pmc The CatSper channel: a polymodal chemosensor in human sperm
    Christoph Brenker
    Center of Advanced European Studies and Research caesar, Abteilung Molekulare Neurosensorik, Bonn, Germany
    EMBO J 31:1654-65. 2012
    The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm...
  7. doi Immunization of male mice with B-cell epitopes in transmembrane domains of CatSper1 inhibits fertility
    Honggang Li
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Fertil Steril 97:445-52. 2012
    To evaluate the contraceptive ability of two B-cell epitopes in CatSper1.
  8. doi The control of male fertility by spermatozoan ion channels
    Polina V Lishko
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 74:453-75. 2012
    ..b>CatSper, a pH-regulated, calcium-selective ion channel, and KSper (Slo3) are core regulators of sperm tail calcium entry ..
  9. pmc p,p'-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations
    Renata S Tavares
    Biology of Reproduction and Stem Cell Group, CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3001 401, Portugal
    Hum Reprod 28:3167-77. 2013
    ..Is the environmental endocrine disruptor p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) able to induce non-genomic changes in human sperm and consequently affect functional sperm parameters?..
  10. doi A Chinese herbal decoction can increase the intracellular Ca2+ concentration and CatSper1 expression in mouse sperm tails
    Shaobo Luo
    Department of Andrology, Air Force General Hospital of PLA, Beijing 100142, PR China
    Mol Med Rep 7:195-200. 2013
    ..on the intracellular calcium (Ca2+) concentration of sperm and the expression of the cation channel 1 of sperm (CatSper1), which is a calcium-channel protein specific to sperm tail, in a murine model of asthenospermia induced with ..
  11. pmc Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm
    Wardah Alasmari
    From the Reproductive and Developmental Biology, Medical School, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 288:6248-58. 2013
    ..Activation of CatSper (by raising pHi or stimulating with progesterone) caused sustained [Ca(2+)]i elevation but did not induce ..
  12. doi Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction
    Vrushali Sagare-Patil
    Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, JM Street, Parel, Mumbai 400 012, India
    Mol Cell Endocrinol 374:82-91. 2013
    ..The activation of AKT in response to progesterone is calcium dependent and the CatSper channel inhibitor mibefradil significantly reduced progesterone mediated AKT phosphorylation...
  13. doi Molecular cloning and analysis of the Catsper1 gene promoter
    Minerva Mata-Rocha
    Unidad de Investigación Médica en Enfermedades Metabólicas, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social IMSS, México DF CP 06720, Mexico
    Mol Hum Reprod 19:336-47. 2013
    ..Here, we report the cloning and characterization of the promoter regions in the human and murine Catsper1 genes...
  14. pmc The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation
    Wardah Alasmari
    Reproductive and Developmental Biology, Medical School, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
    Hum Reprod 28:866-76. 2013
    ..e. related to fertilization success at IVF?..
  15. pmc Investigation in vitro Expression of CatSper Sub Fragment followed by Production of Polyclonal Antibody: Potential Candidate for The Next Generation of Non Hormonal Contraceptive
    Mahboobeh Nazari
    1 Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran 2 Department of Recombinant Technology Research, Nanobiotechnology Research Center, Avicenna Research Institute, Academic Center for Education, Culture and Research ACECR, Tehran, Iran
    Cell J 14:215-24. 2012
    b>CatSper is a voltage-sensitive calcium channel that is specifically expressed in the testis and it has a significant role in sperm performance. CatSper (1-4) ion channel subunit genes, causes sperm cell hyperactivation and male fertility...
  16. pmc Levels of Tektin 2 and CatSper 2 in normozoospermic and oligoasthenozoospermic men and its association with motility, fertilization rate, embryo quality and pregnancy rate
    Rashmi Bhilawadikar
    Jaslok Hospital, 15, Dr G Deshmukh Marg, Mumbai 26, India
    J Assist Reprod Genet 30:513-23. 2013
    To compare the expression profiles of Tektin 2 and CatSper 2 motility proteins in the spermatozoa of normozoospermic and oligoasthenozoospermic men and determine its correlation with sperm motility, fertilization rate, embryo quality and ..
  17. pmc Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient
    James F Smith
    Department of Urology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 110:6823-8. 2013
    ..progesterone-dependent Ca(2+) influx into human spermatozoa is primarily mediated by cationic channel of sperm (CatSper), the principal flagellar Ca(2+) channel of sperm, conclusive loss-of-function genetic evidence for activation of ..
  18. doi CatSper and the relationship of hyperactivated motility to intracellular calcium and pH kinetics in equine sperm
    Shavahn C Loux
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas
    Biol Reprod 89:123. 2013
    ..b>CATSPER1 mRNA was identified in equine sperm by PCR, and CATSPER1 protein was localized to the principal piece on ..
  19. doi The anti-inflammatory drug celecoxib inhibits T-type Ca2+ currents in spermatogenic cells yet it elicits the acrosome reaction in mature sperm
    E Balderas
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, Avenida Universidad 2001, Col Chamilpa, C P 62210 Cuernavaca Mor, Mexico
    FEBS Lett 587:2412-9. 2013
    ..ability Cx has to alkalinize intracellular pH (pHi), which is known to activate the sperm specific Ca(2+) channel CatSper. As the Cx induced [Ca(2+)]i increase is sensitive to mibefradil, a CatSper blocker, this channel may mediate the ..
  20. pmc Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa
    Xu Hui Zeng
    Institute of Life Science, Nanchang University, Nanchang, Jiangxi 330031, China
    J Gen Physiol 142:305-13. 2013
    ..After deletion of any of four CATSPER subunit genes (CATSPER1-4), the major remaining current in mouse sperm is alkalization-activated KSPER current...
  21. ncbi [Yijingfang increases the expression of CatSper1 in mice]
    Shao Bo Luo
    Department of Andrology, General Hospital of Air Force, PLA, Beijing 100142, China
    Zhonghua Nan Ke Xue 16:1047-51. 2010
    To observe the effects of Yijingfang on CatSper1 in the mouse model of cyclophosphamide-induced oligoasthenospermia.
  22. ncbi International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels
    David E Clapham
    Howard Hughes Medical Institute, Children s Hospital, Boston, MA 02115, USA
    Pharmacol Rev 57:451-4. 2005
  23. pmc The role of Hv1 and CatSper channels in sperm activation
    Polina V Lishko
    Department of Physiology, University of California San Francisco, San Francisco, CA 94158, USA
    J Physiol 588:4667-72. 2010
    ..main H(+) extrusion pathway that controls sperm intracellular pH, and the pH-dependent flagellar Ca²(+) channel CatSper is the main pathway for Ca²(+) entry as measured by the whole-cell patch clamp technique...
  24. pmc Genetic male infertility and mutation of CATSPER ion channels
    Michael S Hildebrand
    Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
    Eur J Hum Genet 18:1178-84. 2010
    ..Recently, we identified insertion mutations of the CATSPER1 gene in families with recessively inherited nonsyndromic male infertility (NSMI)...
  25. doi Calcium signaling through CatSper channels in mammalian fertilization
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Physiology (Bethesda) 25:165-75. 2010
    ..This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility...
  26. doi A model of CatSper channel mediated calcium dynamics in mammalian spermatozoa
    Sarah D Olson
    Mathematics Department, Tulane University, 6823 St Charles Ave, New Orleans, LA 70118, USA
    Bull Math Biol 72:1925-46. 2010
    ..It has been observed that Ca(2+) entry through CatSper channels triggers a tail to head Ca(2+) propagation in mouse sperm, as well as a sustained increase of Ca(2+) in ..
  27. doi Effects of sodium fluoride on hyperactivation and Ca2+ signaling pathway in sperm from mice: an in vivo study
    Zilong Sun
    Shanxi Key Laboratory of Ecological Animal Science and Environmental Medicine, Shanxi Agricultural University, Taigu, 030801 Shanxi, People s Republic of China
    Arch Toxicol 84:353-61. 2010
    ..was to investigate the effect of sodium fluoride (NaF) on sperm hyperactivation, Ca2+/CALM-CAMK2 signaling, and CatSper1 and CatSper2 mRNA expression in mice sperm...
  28. pmc Two distinct Ca(2+) signaling pathways modulate sperm flagellar beating patterns in mice
    Haixin Chang
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Biol Reprod 85:296-305. 2011
    ..In vitro, sperm that hyperactivated during capacitation (because of activation of CATSPER plasma membrane Ca(2+) channels) developed high-amplitude pro-hook bends...
  29. ncbi [CatSper1 protein and idiopathic asthenozoospermia]
    Wen Bin Wu
    Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
    Zhonghua Nan Ke Xue 17:110-4. 2011
    To investigate the role of the cation channel of sperm 1 (CatSper1) protein in the pathogenesis of idiopathic asthenozoospermia.
  30. doi The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
    Timo Strünker
    Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Nature 471:382-6. 2011
    ..Here we show that progesterone activates the sperm-specific, pH-sensitive CatSper Ca(2+) channel...
  31. pmc Molecular cloning, spatial and temporal expression analysis of CatSper genes in the Chinese Meishan pigs
    Chengyi Song
    College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009, China
    Reprod Biol Endocrinol 9:132. 2011
    b>Sperm ion channel proteins (CatSpers) are essential for sperm hyperactivated motility, and then penetration through the zona pellucida. The CatSper class of proteins have well been characterized in the mouse and human...
  32. doi Calcium channels in the development, maturation, and function of spermatozoa
    Alberto Darszon
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    Physiol Rev 91:1305-55. 2011
    ..Remarkably, these tiny specialized cells can express exclusive channels like CatSper for Ca(2+) and SLO3 for K(+), which are attractive targets for contraception and for the discovery of novel ..
  33. pmc ATP-activated P2X2 current in mouse spermatozoa
    Betsy Navarro
    Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:14342-7. 2011
    ..This enhanced motility requires Ca(2+) entry via cation channel of sperm (CatSper) Ca(2+)-selective ion channels in the sperm tail...
  34. pmc Coupling biochemistry and hydrodynamics captures hyperactivated sperm motility in a simple flagellar model
    Sarah D Olson
    Mathematics Department, Tulane University, 6823 St Charles Ave, New Orleans, LA 70118, USA
    J Theor Biol 283:203-16. 2011
    ..Here we present an integrative model that couples the CatSper channel mediated Ca(2+) dynamics of hyperactivation to a mechanical model of an idealized sperm flagellum in a 3-..
  35. pmc Rediscovering sperm ion channels with the patch-clamp technique
    Yuriy Kirichok
    Department of Physiology, University of California San Francisco UCSF Mail Code 2140, Genentech Hall Room N272F 600 16th Street, San Francisco, CA 94158, USA
    Mol Hum Reprod 17:478-99. 2011
    ..Finally, we focus on the newly discovered sperm ion channels CatSper, KSper (Slo3) and HSper (H(v)1), identified by the sperm patch-clamp technique...
  36. pmc Mathematical modeling of calcium signaling during sperm hyperactivation
    S D Olson
    Department of Mathematics, Tulane University, New Orleans, LA 70115 USA
    Mol Hum Reprod 17:500-10. 2011
    ..The major mechanism for providing Ca(2+) to the flagellum, at least in mice, are CatSper channels in the plasma membrane of the principal piece of the flagellum, because sperm from CatSper null males ..
  37. pmc Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa
    Xu Hui Zeng
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:5879-84. 2011
    ..The properties of I(Kres) suggest that it likely represents outward monovalent cation flux through CatSper channels...
  38. doi Progesterone activates the principal Ca2+ channel of human sperm
    Polina V Lishko
    Department of Physiology, University of California San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F, 600 16th Street, San Francisco, California 94158, USA
    Nature 471:387-91. 2011
    ..to mature human spermatozoa, we found that nanomolar concentrations of progesterone dramatically potentiate CatSper, a pH-dependent Ca(2+) channel of the sperm flagellum...
  39. pmc Up-regulation of CatSper genes family by selenium
    Shabnam Mohammadi
    Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Reprod Biol Endocrinol 7:126. 2009
    b>CatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility...
  40. pmc The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, 415 S University Ave, Philadelphia, Pennsylvania 19104, USA
    Reprod Biol Endocrinol 7:119. 2009
    ..Both of these processes require extracellular calcium, but how calcium enters sperm during capacitation is not well understood...
  41. ncbi Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse
    Jingling Jin
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Biol Reprod 77:37-44. 2007
    Catsper3 and Catsper4 are two recently identified testis-specific genes homologous to Catsper1 and Catsper2 that have been shown to play an essential role in sperm hyperactivated motility and male fertility in mice...
  42. pmc All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
    Huayu Qi
    Department of Cardiology, Howard Hughes Medical Institute, and Department of Neurobiology, Harvard Medical School, Enders 1309, Children s Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:1219-23. 2007
    ..Hyperactivation requires CatSper1 and CatSper2 putative ion channel genes, but the function of two other related genes (CatSper3 and CatSper4) is ..
  43. pmc Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm
    Becky Marquez
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 303:214-21. 2007
    ..In sperm from CatSper1 or CatSper2 null mice, which lack functional flagellar alkaline-activated calcium currents, 50 microM thimerosal ..
  44. ncbi Voltage-dependent calcium channels in mammalian spermatozoa revisited
    Susan Benoff
    Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Front Biosci 12:1420-49. 2007
    ..However, the large number of sperm ion channel variants shared with other cell types make ion channels less attractive targets for male contraceptive ..
  45. ncbi [Expression characteristics of mouse Catsper--the structural protein of sperm hyperactivation]
    Yuan yuan Yang
    Animal Science and Technology College, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Zhonghua Nan Ke Xue 12:675-80. 2006
    To study the expression specificity in tissues of the Catsper and its expression rules, which is a specification channels in sperm and plays an important role in sperm hyperactivation.
  46. ncbi Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity
    Di Zhang
    Neuroscience Research and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Biol Chem 281:22332-41. 2006
    Sperm-specific CatSper1 and CatSper2 proteins are critical to sperm-hyperactivated motility and male fertility...
  47. ncbi The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa
    Hong Gang Li
    Centre of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Asian J Androl 8:301-6. 2006
    To investigate the distribution of cation channel of sperm 1 (CATSPER1) protein and the presence of CATSPER1 mRNA in human testis and ejaculated spermatozoa...
  48. ncbi Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel
    Yuriy Kirichok
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital and Harvard Medical School Enders 1309, Boston, Massachusetts 02115, USA
    Nature 439:737-40. 2006
    ..This current is not present in spermatozoa lacking the sperm-specific putative ion channel protein, CatSper1. This plasma membrane protein of the six transmembrane-spanning ion channel superfamily is specifically localized ..
  49. ncbi Insights into sperm cell motility signaling through sNHE and the CatSpers
    Timothy A Quill
    Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell Endocrinol 250:84-92. 2006
    ..of sNHE and the atypical adenylyl cyclase (sAC), while a failure of calcium entry requiring an apparent CatSper1 and -2 heteromeric ion channel correlates with a hyperactivation defect in these null animals...
  50. ncbi Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis
    Jing Ling Jin
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Biol Reprod 73:1235-42. 2005
    b>CATSPER1 and CATSPER2 are two cation channel-like proteins exclusively expressed in the testis and essential for normal sperm motility and male fertility...
  51. ncbi Identical phenotypes of CatSper1 and CatSper2 null sperm
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Biol Chem 280:32238-44. 2005
    Among several candidate Ca(2+) entry channels in sperm, only CatSper1 and CatSper2 are known to have required roles in male fertility...
  52. pmc Positive selection for indel substitutions in the rodent sperm protein catsper1
    Ondrej Podlaha
    Department of Ecology and Evolutionary Biology, University of Michigan, USA
    Mol Biol Evol 22:1845-52. 2005
    b>Catsper1 is a voltage-gated calcium channel located in the plasma membrane of the sperm tail and is necessary for sperm motility and fertility in mice...
  53. ncbi Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4
    Gbolahan W Okunade
    Department of Molecular Genetics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 279:33742-50. 2004
    ..it is localized to the principle piece of the sperm tail, which is also the location of the major Ca2+ channel (CatSper) required for sperm motility...
  54. ncbi CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility
    Parvaneh Nikpoor
    Department of Genetics, Faculty of Basic Sciences, Tarbiat Modarres University, Tehran, 14115 175, Iran
    Hum Reprod 19:124-8. 2004
    ..for Ca2+ channels residing in sperm has led to the recent cloning and characterization of a novel gene, named CatSper, which codes for a unique Ca2+ channel expressed exclusively in the testis...
  55. pmc CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:14864-8. 2003
    ..Here, we show that mouse CatSper1 is essential for depolarization-evoked Ca2+ entry and for hyperactivated movement, a key flagellar function...
  56. pmc Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis
    Anna Lobley
    Target Discovery, Inpharmatica Ltd, 60 Charlotte Street, London W1T 2NU, UK
    Reprod Biol Endocrinol 1:53. 2003
    b>CatSper1 and CatSper2 are two recently identified channel-like proteins, which show sperm specific expression patterns...
  57. pmc A voltage-gated ion channel expressed specifically in spermatozoa
    T A Quill
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 98:12527-31. 2001
    ..Recently, another voltage-gated channel (CatSper) that has features similar to the one reported here was discovered...
  58. ncbi [CatSper and sperm hyperactivation]
    Li juan Kong
    Animal Science and Technology College, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Zhonghua Nan Ke Xue 13:164-7. 2007
    ..b>CatSper family proteins are putative cation channels expressed exclusively in the membranes of the sperm flagellum...
  59. ncbi Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility
    Hong Gang Li
    Centre of Reproductive Medicine and Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Hum Reprod 13:299-306. 2007
    ..The temporal expression profiles of CatSper1-4 mRNAs in the mouse testis during post-natal development through adulthood were investigated using real-time RT-..
  60. pmc KSper, a pH-sensitive K+ current that controls sperm membrane potential
    Betsy Navarro
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:7688-92. 2007
    ..reproductive tract, the spermatozoan cytoplasm alkalinizes, which in turn activates a Ca2+-selective current (I(CatSper)) required for hyperactivated motility...
  61. pmc Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e6844. 2009
    The four sperm-specific CatSper ion channel proteins are required for hyperactivated motility and male fertility, and for Ca(2+) entry evoked by alkaline depolarization...
  62. pmc Ca2+-stores in sperm: their identities and functions
    Sarah Costello
    School of Biosciences, University of Birmingham, Birmingham B152TT, UK
    Reproduction 138:425-37. 2009
    ..of the sperm discretely to control mobilisation of these stores and the functional interaction of stored Ca2+ at the sperm neck/midpiece with CatSper channels in the principal piece in regulation of the activities of mammalian sperm.
  63. pmc A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 81:539-44. 2009
    All four CATSPER channel pore-forming subunits (CATSPER1-4) are localized in the sperm principal piece...
  64. pmc Human male infertility caused by mutations in the CATSPER1 channel protein
    Matthew R Avenarius
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109 0618, USA
    Am J Hum Genet 84:505-10. 2009
    ..1, flanked by markers D11S1765 and D11S4139. This region contains the human CATSPER1 gene...
  65. pmc Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 80:1092-8. 2009
    ..Instead, CATSPER channels localized in the distal portion of sperm (the principal piece) are required for the ZP-induced [Ca(2+)](..
  66. ncbi CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir
    Katharine Ho
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Reprod Fertil Dev 21:345-50. 2009
    ..To test this hypothesis, the behaviour of CatSper-null mouse spermatozoa in the oviduct was compared with that of spermatozoa from heterozygotes...
  67. ncbi [Roles of calcium ion channels and its clinical significance in sperm motility]
    Yong Wang
    Department of Physiology, Medical College of Shantou University, Shantou, Guangdong 515041, China
    Zhonghua Nan Ke Xue 14:832-6. 2008
    ..voltage-gated Ca2+ channels (Cav channels), cyclic nucleotide-gated channels (CNGC), cation channels of sperm (CatSper) and the transient receptor potential (TRP) family...
  68. doi Inhibition of human sperm function and mouse fertilization in vitro by an antibody against cation channel of sperm 1: the contraceptive potential of its transmembrane domains and pore region
    Honggang Li
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Fertil Steril 92:1141-6. 2009
    To explore the contraceptive potential of the CatSper1 transmembrane domains and pore region in vitro.
  69. pmc Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta
    Xinjiang Cai
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 3:e3569. 2008
    The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility...
  70. pmc Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse
    Anuradha Dhingra
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    J Comp Neurol 510:484-96. 2008
    ..RGS10, RGS19 (GAIP), calbindin, GC1alpha2, GC1beta2, PDE5, PDE2A, amiloride-sensitive sodium channel ACCN4, and CatSper1. We then localized Kir2...
  71. doi Control of hyperactivation in sperm
    Susan S Suarez
    Department of Biomedical Sciences, T5 002B Veterinary Research Tower, Cornell University Ithaca, NY 14853, USA
    Hum Reprod Update 14:647-57. 2008
    ..Hyperactivation is characterized by high amplitude, asymmetrical flagellar bending...
  72. doi Ion channels that control fertility in mammalian spermatozoa
    Betsy Navarro
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Department of Neurobiology, Harvard Medical School, Enders 1309, Children s Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA
    Int J Dev Biol 52:607-13. 2008
    ..This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible...
  73. doi CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model
    J Rezaian
    Department of Anatomical Sciences, Tarbiat Modares University, Tehran, Iran
    Spinal Cord 47:76-81. 2009
    ..Experimental study...
  74. ncbi [Optimization of real time RT-PCR system for the quantitative estimation of CatSper1 mRNA levels in human and mouse mature spermatozoa]
    Hong Gang Li
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wu Han, Hubei 430030, China
    Zhonghua Nan Ke Xue 13:969-74. 2007
    To establish and optimize a real time RT-PCR system for determining the transcript levels of CatSper1 in human and mouse mature spermatozoa containing microamount of RNA.
  75. ncbi Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum
    Susan S Suarez
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Soc Reprod Fertil Suppl 65:331-4. 2007
    ..is required for activation of motility, is restricted to the midpiece, while the plasma membrane calcium channels CatSper1 and CatSper2, which are required for hyperactivation of motility, are restricted to the principal piece...
  76. ncbi CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 77:551-9. 2007
    ..In addition, CatSper1-mutant sperm have lower intracellular ATP levels than wild-type sperm...
  77. ncbi CatSperbeta, a novel transmembrane protein in the CatSper channel complex
    Jin Liu
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:18945-52. 2007
    ..Using a transgenic approach, a CatSper1 complex was purified from mouse testis that contained heat shock protein 70-2, a testis-specific chaperone, and ..
  78. ncbi Ion channels. Swimming with sperm
    D L Garbers
    Nature 413:579, 581-2. 2001

Research Grants64

  1. Male contraception/CatSper1,2 sperm-specific ion channel
    David Clapham; Fiscal Year: 2007
    ..2001). CatSper1, the first of these ion channels to be identified, triggers calcium influx into the principal piece of the sperm ..
  2. CatSper: Novel target for an oral contraceptive
    JAYHONG CHONG; Fiscal Year: 2003
    ..D./ Ph.D., of a sperm specific ion channel, CatSper. Male mice lacking CatSper have poor sperm motility and are sterile. These and other studies carried out by Dr...
  3. SPERM ION CHANNEL REGULATION
    HARVEY FLORMAN; Fiscal Year: 2002
    ..Moreover, an understanding of the regulation of this channel is a necessary step in attempts to design channel-based contraceptive agents. ..
  4. Novel CatSper3 and CatSper4 Ion Channel Genes in Sperm
    David Clapham; Fiscal Year: 2007
    ..b>CatSper1 is an ion channel that triggers calcium-influx into the principal piece of the sperm tail...
  5. The Protein Complex of a Sperm Ion Channel
    Dejian Ren; Fiscal Year: 2006
    ..This proposal focuses on the role of a sperm tail ion channel (CatSper1) that is specifically required for male fertility...
  6. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2010
    ..This proposal focuses on the roles of a sperm tail ion channel (CatSper1) we discovered. CatSper1 from human and mice is only expressed in testis...
  7. DISCOVERY & FUNCTION OF FERTILIZATION-SPECIFIC MOLECULES
    Timothy Quill; Fiscal Year: 2007
    ..Based on these studies, linkage maps will begin to connect pathways from the sNHE, or other candidate gene products, to sperm behavioral responses such as motility activation or induction of the acrosome reaction. ..
  8. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2007
    ..This proposal focuses on the roles of a sperm tail ion channel (CatSper1) we discovered. CatSper1 from human and mice is only expressed in testis...
  9. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2009
    ..They may also reveal how the function of the protein can influence neuronal excitabilities in physiological and pathophysiological conditions such as paralysis, seizure and epilepsy. ..
  10. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2009
    ..They may also reveal how the function of the protein can influence neuronal excitabilities in physiological and pathophysiological conditions such as paralysis, seizure and epilepsy. ..
  11. Sodium Leak Channels and Regulation by Neurotransmitters
    Dejian Ren; Fiscal Year: 2010
    ..They may also reveal how the function of the protein can influence neuronal excitabilities in physiological and pathophysiological conditions such as paralysis, seizure and epilepsy. ..
  12. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2010
    ....
  13. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  14. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  15. HUMAN SPERM ZONA ACCEPTOR--ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2000
    ..The strength application include the expertise and experience of the principal investigator Dr. Benoff and her research team, the novel approach to analysis of the problem. ..
  16. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..