cathepsin L

Summary

Gene Symbol: cathepsin L
Description: cathepsin L
Alias: CATL, CTSL1, MEP, cathepsin L1, major excreted protein
Species: human
Products:     cathepsin L

Top Publications

  1. Goulet B, Baruch A, Moon N, Poirier M, Sansregret L, Erickson A, et al. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell. 2004;14:207-19 pubmed
    ..Furthermore, few specific protein substrates for these proteases have been identified. We show here that cathepsin L functions in the regulation of cell cycle progression through proteolytic processing of the CDP/Cux ..
  2. Wille A, Gerber A, Heimburg A, Reisenauer A, Peters C, Saftig P, et al. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells. Biol Chem. 2004;385:665-70 pubmed
    ..The aim of the present study was to investigate the function of cathepsin L (catL) in the proteolytic network of human lung epithelial cells and its role in the regulation of apoptosis...
  3. Ljunggren A, Redzynia I, Alvarez Fernandez M, Abrahamson M, Mort J, Krupa J, et al. Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease. J Mol Biol. 2007;371:137-53 pubmed publisher
    ..We have crystallized and solved the structure of chagasin in complex with the host cysteine protease, cathepsin L, at 1.75 A resolution...
  4. Xu X, Yuan G, Liu W, Zhang Y, Chen W. Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance. Exp Oncol. 2009;31:102-5 pubmed
    To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors...
  5. Ceru S, Konjar S, Maher K, Repnik U, Krizaj I, Bencina M, et al. Stefin B interacts with histones and cathepsin L in the nucleus. J Biol Chem. 2010;285:10078-86 pubmed publisher
    ..The delay in cell cycle progression was associated with the inhibition of cathepsin L in the nucleus, as judged from the decreased cleavage of the CUX1 transcription factor...
  6. Kenig S, Frangez R, Pucer A, Lah T. Inhibition of cathepsin L lowers the apoptotic threshold of glioblastoma cells by up-regulating p53 and transcription of caspases 3 and 7. Apoptosis. 2011;16:671-82 pubmed publisher
    ..b>Cathepsin L inhibition was suggested as one of such modifications but the mechanism of cathepsin L anti-apoptotic activity ..
  7. Miyamoto K, Iwadate M, Yanagisawa Y, Ito E, Imai J, Yamamoto M, et al. Cathepsin L is highly expressed in gastrointestinal stromal tumors. Int J Oncol. 2011;39:1109-15 pubmed publisher
    ..A lysosomal cysteine proteinase termed cathepsin L has been commonly associated with malignancy in several cancer types, but this finding has not been reported ..
  8. Fujishima A, Imai Y, Nomura T, Fujisawa Y, Yamamoto Y, Sugawara T. The crystal structure of human cathepsin L complexed with E-64. FEBS Lett. 1997;407:47-50 pubmed
    We have determined the three dimensional structure of the complex of human cathepsin L and E-64, an irreversible inhibitor of cysteine proteases, at 2.5 A resolution...
  9. Novinec M, Grass R, Stark W, Turk V, Baici A, Lenarcic B. Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors. J Biol Chem. 2007;282:7893-902 pubmed
    ..Studies of enzyme partitioning between the phases showed that cathepsin K favors adsorption on elastin; cathepsin L prefers the aqueous environment, and cathepsin S is equally distributed among both phases...

More Information

Publications128 found, 100 shown here

  1. Sullivan S, Tosetto M, Kevans D, Coss A, Wang L, O Donoghue D, et al. Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer. Int J Cancer. 2009;125:54-61 pubmed publisher
    Previous in vitro studies have identified a nuclear isoform of Cathepsin L. The aim of this study was to examine if nuclear Cathepsin L exists in vivo and examine its association with clinical, pathological and patient outcome data...
  2. Lankelma J, Voorend D, Barwari T, Koetsveld J, Van der Spek A, De Porto A, et al. Cathepsin L, target in cancer treatment?. Life Sci. 2010;86:225-33 pubmed publisher
    b>Cathepsin L, a cysteine protease, is considered to be a potential therapeutic target in cancer treatment. Proteases are involved in the development and progression of cancer...
  3. Yan J, Xiao H, Ji H, Shen W, Zhou Z, Song B, et al. Cathepsin L is associated with proliferation and clinical outcome of urothelial carcinoma of the bladder. J Int Med Res. 2010;38:1913-22 pubmed
    Increasing evidence suggests that the activity of cysteine proteases, including cathepsin L, is important in cancer cell invasion and metastasis...
  4. Gonzalez Suarez I, Redwood A, Grotsky D, Neumann M, Cheng E, Stewart C, et al. A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair. EMBO J. 2011;30:3383-96 pubmed publisher
    ..We demonstrate an unprecedented role for the cysteine protease Cathepsin L (CTSL) in the degradation of 53BP1...
  5. Cancela M, Corvo I, da Silva E, Teichmann A, Roche L, Diaz A, et al. Functional characterization of single-domain cystatin-like cysteine proteinase inhibitors expressed by the trematode Fasciola hepatica. Parasitology. 2017;144:1695-1707 pubmed publisher
    ..Recombinant rFhStf-1, -2 and -3 had potent inhibitory activity against F. hepatica cathepsin L cysteine proteinases but differed in their capacity to inhibit mammalian cathepsin B, L and C...
  6. Rasoolizadeh A, Goulet M, Guay J, Cloutier C, Michaud D. Population-associated heterogeneity of the digestive Cys protease complement in Colorado potato beetle, Leptinotarsa decemlineata. J Insect Physiol. 2018;106:125-133 pubmed publisher
    ..Cathepsin D activity, cathepsin L activity, cathepsin B activity and total intestain content shortly after larval molting on potato leaves were ..
  7. Sendler M, Weiss F, Golchert J, Homuth G, van den Brandt C, Mahajan U, et al. Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice. Gastroenterology. 2018;154:704-718.e10 pubmed publisher
    ..Pancreatitis was induced in C57Bl/6 wild-type (control), cathepsin B (CTSB)-knockout, and cathepsin L-knockout mice by partial pancreatic duct ligation with supramaximal caerulein injection, or by repetitive ..
  8. Wang Y, Zhou Y, Gong H, Cao J, Zhang H, Li X, et al. Functional characterization of a cystatin from the tick Rhipicephalus haemaphysaloides. Parasit Vectors. 2015;8:140 pubmed publisher
    ..a glutathione S-transferase (GST)-fused soluble form in Escherichia coli, and its inhibitory activity against cathepsin L, B, C, H, and S, as well as papain, was identified by fluorogenic substrate analysis...
  9. Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley J, et al. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015;116:76-84 pubmed publisher
    ..of Ebola virus, as well as SARS- and MERS-coronavirus can be accomplished by the endosomal cysteine proteases, cathepsin L (CTSL) and cathepsin B (CTSB)...
  10. Kędzior M, Pawlak A, Seredyński R, Bania J, Platt Samoraj A, Czemplik M, et al. Revealing the inhibitory potential of Yersinia enterocolitica on cysteine proteases of the papain family. Microbiol Res. 2018;207:211-225 pubmed publisher
    ..enterocolitica strains of different bioserotypes and genotypes synthesize papain and human cathepsin L inhibitors, but not bovine cathepsin B inhibitors...
  11. Matsuyama S, Shirato K, Kawase M, Terada Y, Kawachi K, Fukushi S, et al. Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells. J Virol. 2018;92: pubmed publisher
    ..In addition, dec-RVKR-CMK inhibited not only the enzymatic activity of furin but also those of cathepsin L, cathepsin B, trypsin, papain, and TMPRSS2...
  12. Wang Y, Wu L, Liu X, Wang S, Ehsan M, Yan R, et al. Characterization of a secreted cystatin of the parasitic nematode Haemonchus contortus and its immune-modulatory effect on goat monocytes. Parasit Vectors. 2017;10:425 pubmed publisher
    ..expressed in a histidine-tagged fusion soluble form in Escherichia coli, and its inhibitory activity against cathepsin L, B, as well as papain, were identified by fluorogenic substrate analysis...
  13. Oortveld M, van Vlijmen Willems I, Kersten F, Cheng T, Verdoes M, van Erp P, et al. Cathepsin B as a potential cystatin M/E target in the mouse hair follicle. FASEB J. 2017;31:4286-4294 pubmed publisher
    ..M. J. J., Kersten, F. F. J., Cheng, T., Verdoes, M., van Erp, P. E. J., Verbeek, S., Reinheckel, T., Hendriks, W. J. A. J., Schalkwijk, J., Zeeuwen, P. L. J. M. Cathepsin B as a potential cystatin M/E target in the mouse hair follicle. ..
  14. Martynov A, Elpidina E, Perkin L, Oppert B. Functional analysis of C1 family cysteine peptidases in the larval gut of Тenebrio molitor and Tribolium castaneum. BMC Genomics. 2015;16:75 pubmed publisher
    ..castaneum, 25 genes and one questionable pseudogene encoding cysteine peptidases were identified, including 11 cathepsin L or L-like, 11 cathepsin B or B-like, and one each F, K, and O...
  15. Gonzalez Leal I, Röger B, Schwarz A, Schirmeister T, Reinheckel T, Lutz M, et al. Cathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infection. PLoS Negl Trop Dis. 2014;8:e3194 pubmed publisher
    ..major. Moreover, they propose a novel role for Ctsb as a regulator of cytokine expression. ..
  16. Ettari R, Previti S, Tamborini L, Cullia G, Grasso S, Zappala M. The Inhibition of Cysteine Proteases Rhodesain and TbCatB: A Valuable Approach to Treat Human African Trypanosomiasis. Mini Rev Med Chem. 2016;16:1374-1391 pubmed
    ..Rhodesain, the major cathepsin L-like cysteine protease of T. brucei rhodesiense, is a lysosomal protease essential for parasite survival...
  17. Liu W, Xu B, Ye L, Liang D, Wu H, Zheng Y, et al. Urinary proteins induce lysosomal membrane permeabilization and lysosomal dysfunction in renal tubular epithelial cells. Am J Physiol Renal Physiol. 2015;308:F639-49 pubmed publisher
    ..Taken together, our results indicate that overloading of urinary proteins caused LMP and lysosomal dysfunction at least partly via oxidative stress in TECs. ..
  18. Srp J, Nussbaumerová M, Horn M, Mares M. Digestive proteolysis in the Colorado potato beetle, Leptinotarsa decemlineata: Activity-based profiling and imaging of a multipeptidase network. Insect Biochem Mol Biol. 2016;78:1-11 pubmed publisher
    ..The secreted luminal peptidases were classified as: (i) endopeptidases of cathepsin D, cathepsin L, and trypsin types and (ii) exopeptidases with aminopeptidase (cathepsin H), carboxypeptidase (serine ..
  19. Saidi A, Kasabova M, Vanderlynden L, Wartenberg M, Kara Ali G, Marc D, et al. Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L. Sci Rep. 2019;9:491 pubmed publisher
    ..Curcumin induced a compelling upregulation of CatB and CatL. Conversely cystatin C was downregulated, which allowed the recovery of the peptidase activity of secreted ..
  20. Santamaría M, González Cabrera J, Martínez M, Grbic V, Castañera P, Díaz L, et al. Digestive proteases in bodies and faeces of the two-spotted spider mite, Tetranychus urticae. J Insect Physiol. 2015;78:69-77 pubmed publisher
    ..and legumain activities were detected in both mite bodies and faeces, with a specific activity of aspartyl and cathepsin L-like proteases about 5- and 2-fold higher, respectively, in mite faeces than in bodies...
  21. Harbeck N, Alt U, Berger U, Kates R, Kruger A, Thomssen C, et al. Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer. Int J Biol Markers. 2000;15:79-83 pubmed
    ..001; RR = 3.8), cathepsin L (p < 0.001; RR = 2.6) and PAI-1 (p = 0.027; RR = 1.7) were significant factors in all patients...
  22. Fuzita F, Pinkse M, Verhaert P, Lopes A. Cysteine cathepsins as digestive enzymes in the spider Nephilengys cruentata. Insect Biochem Mol Biol. 2015;60:47-58 pubmed publisher
    ..Evolutionarily, arachnid cathepsin L may have acquired different roles but its use for digestion is a common feature to studied taxa...
  23. Massai L, Messori L, Micale N, Schirmeister T, Maes L, Fregona D, et al. Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents. Biometals. 2017;30:313-320 pubmed publisher
    ..here: cathepsin B and L that play a primary role in tumor-cell invasion and metastasis; rhodesain, the major cathepsin L-like cysteine protease of Trypanosoma brucei rhodesiense and CPB2...
  24. Bai X, Kinney W, Su W, Bai A, Ovrutsky A, Honda J, et al. Caspase-3-independent apoptotic pathways contribute to interleukin-32γ-mediated control of Mycobacterium tuberculosis infection in THP-1 cells. BMC Microbiol. 2015;15:39 pubmed publisher
    ..were infected with MTB H37Rv alone or in the presence of specific inhibitors to caspase-1, cathepsin B/D, or cathepsin L for up to four days, after which TUNEL-positive cells were quantified; in addition, MTB was quantified by ..
  25. Schurigt U, Eilenstein R, Gajda M, Leipner C, Sevenich L, Reinheckel T, et al. Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment. Inflamm Res. 2012;61:1021-9 pubmed publisher
    b>Cathepsin L (CL) is potentially involved in joint destruction and in antigen presentation in rheumatoid arthritis...
  26. Seto S, Parks A, Qiu Y, Soslowsky L, Karas S, Platt M, et al. Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model. Ann Biomed Eng. 2015;43:2036-46 pubmed publisher
    ..In both 4- and 8-week overuse groups, via zymography, there was approximately a 180% increase in cathepsin L activity at the insertion region compared to the controls, while no difference was found in the midsubstance ..
  27. Lapole T, Temesi J, Arnal P, Gimenez P, Petitjean M, Millet G. Modulation of soleus corticospinal excitability during Achilles tendon vibration. Exp Brain Res. 2015;233:2655-62 pubmed publisher
    ..008). Input-output curves were also influenced by vibration, i.e. there was increased maximal MEP amplitude (0.694 ± 0.347 vs. 0.268 ± 0.167 mV; p < 0...
  28. Pankratov I, McQuinn R, Schwartz J, Bar E, Fei Z, Lewinsohn E, et al. Fruit carotenoid-deficient mutants in tomato reveal a function of the plastidial isopentenyl diphosphate isomerase (IDI1) in carotenoid biosynthesis. Plant J. 2016;88:82-94 pubmed publisher
    ..from mevalonic acid via the MVA pathway, and in plastids from 2-C-methyl-d-erythritol-4-phosphate through the MEP pathway. The enzyme IDP isomerase (IDI) catalyzes the interconversion between IDP and DMADP...
  29. Kudoh K, Kubota G, Fujii R, Kawano Y, Ihara M. Exploration of the 1-deoxy-d-xylulose 5-phosphate synthases suitable for the creation of a robust isoprenoid biosynthesis system. J Biosci Bioeng. 2017;123:300-307 pubmed publisher
    1-Deoxy-d-xylulose 5-phosphate synthase (DXS) is a rate-limiting enzyme in the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway, which is responsible for production of two precursors of all isoprenoids, isopentenyl diphosphate and ..
  30. Watkins D, Sanchez B, Tellez Rojo M, Lee J, Mercado Garcia A, Blank Goldenberg C, et al. Phthalate and bisphenol A exposure during in utero windows of susceptibility in relation to reproductive hormones and pubertal development in girls. Environ Res. 2017;159:143-151 pubmed publisher
    ..For example, an interquartile range (IQR) increase in mean monoethyl phthalate (MEP) levels across pregnancy was associated with 44% higher peripubertal testosterone (95% CI: 13-83%), while an IQR ..
  31. Hirano A, Maruyama T, Shiraki K, Arakawa T, Kameda T. Mechanism of protein desorption from 4-mercaptoethylpyridine resins by arginine solutions. J Chromatogr A. 2014;1373:141-8 pubmed publisher
    A multimodal chromatography column containing 4-mercaptoethylpyridine (4-MEP) as a resin ligand is capable of binding antibodies. Arginine has been proven effective for eluting bound antibodies from the 4-MEP resin column...
  32. Schirmeister T, Schmitz J, Jung S, Schmenger T, Krauth Siegel R, Gutschow M. Evaluation of dipeptide nitriles as inhibitors of rhodesain, a major cysteine protease of Trypanosoma brucei. Bioorg Med Chem Lett. 2017;27:45-50 pubmed publisher
    ..dipeptide nitriles known as inhibitors of mammalian cathepsins were evaluated for inhibition of rhodesain, the cathepsin L-like protease of Trypanosoma brucei...
  33. Carvalho P, Custodio J, Vaz W, Cirilo C, Cidade A, Aquino G, et al. Conformation analysis of a novel fluorinated chalcone. J Mol Model. 2017;23:97 pubmed publisher
    ..The molecular electrostatic potential (MEP) was also investigated at the same level of theory in order to identify and quantify the possible reactive sites...
  34. Yamada Y, Kato Y, Nouri M, Ganaha T, Oheda M, Ishihara K, et al. Predictive Value of Motor Evoked Potential Monitoring during Surgery of Unruptured Anterior Circulation Cerebral Aneurysms. Asian J Neurosurg. 2017;12:644-647 pubmed publisher
    ..Here, we present our experience with selective motor evoked potential (MEP) monitoring of our patients in a 2-year time window.
  35. Taylor J, Allen G, Butler J, Gandevia S. Supraspinal fatigue during intermittent maximal voluntary contractions of the human elbow flexors. J Appl Physiol (1985). 2000;89:305-13 pubmed
    ..5 to 7% of ongoing torque. Thus "supraspinal" fatigue developed in each protocol. The motor evoked potential (MEP) and silent period in the elbow flexor muscles also changed...
  36. Meincke J, Hewitt M, Batsikadze G, Liebetanz D. Automated TMS hotspot-hunting using a closed loop threshold-based algorithm. Neuroimage. 2016;124:509-517 pubmed publisher
    ..AHH is based on resting motor thresholds (RMTs) instead of MEP amplitudes...
  37. Xu C, Li H, Yang X, Gu C, Mu H, Yue Y, et al. Cloning and Expression Analysis of MEP Pathway Enzyme-encoding Genes in Osmanthus fragrans. Genes (Basel). 2016;7: pubmed
    The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway is responsible for the biosynthesis of many crucial secondary metabolites, such as carotenoids, monoterpenes, plastoquinone, and tocopherols...
  38. Shirato K, Kanou K, Kawase M, Matsuyama S. Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. J Virol. 2017;91: pubmed publisher
    ..by cell surface proteases, particularly transmembrane protease serine 2 (TMPRSS2), and the other by endosomal cathepsin L. Thus, specific inhibitors of these proteases block virus infection...
  39. Pimentel A, Fuzita F, Palmisano G, Ferreira C, Terra W. Role of cathepsins D in the midgut of Dysdercus peruvianus. Comp Biochem Physiol B Biochem Mol Biol. 2017;204:45-52 pubmed publisher
    ..Digestive cathepsins D apparently complement the action of digestive cathepsin L and they are arguably responsible for the hydrolysis of cysteine peptidase inhibitors known to be present in ..
  40. Goetz S, Luber B, Lisanby S, Murphy D, Kozyrkov I, Grill W, et al. Enhancement of Neuromodulation with Novel Pulse Shapes Generated by Controllable Pulse Parameter Transcranial Magnetic Stimulation. Brain Stimul. 2016;9:39-47 pubmed publisher
    ..changes due to rTMS were measured by applying probe TMS pulses before and after rTMS, and comparing resultant MEP amplitudes. Separately, we measured the latency of the MEPs evoked by each of the four pulses...
  41. Corry J, Johnson S, Cornwell J, Peeples M. Preventing Cleavage of the Respiratory Syncytial Virus Attachment Protein in Vero Cells Rescues the Infectivity of Progeny Virus for Primary Human Airway Cultures. J Virol. 2016;90:1311-20 pubmed publisher
    ..Using protease inhibitors with increasing specificity, we identified cathepsin L to be the protease responsible for cleavage...
  42. Jayaswal A, Kandwal P, Goswami A, Vijayaraghavan G, Jariyal A, Upendra B, et al. Early onset scoliosis with intraspinal anomalies: management with growing rod. Eur Spine J. 2016;25:3301-3307 pubmed
    ..While other patient experienced MEP changes during index procedure...
  43. Gao H, Zhu Y, Xu Y, Zhang Y, Yao H, Sheng J, et al. Season-dependent concentrations of urinary phthalate metabolites among Chinese pregnant women: Repeated measures analysis. Environ Int. 2017;104:110-117 pubmed publisher
    ..phthalate metabolites from urine samples were analyzed, including monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), mono benzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), mono (2-ethyl-5-..
  44. Strojnik T, Lah T, Zidanik B. Immunohistochemical staining of cathepsins B, L and stefin A in human hypophysis and pituitary adenomas. Anticancer Res. 2005;25:587-94 pubmed
    ..Therefore, we propose that this enzyme is evaluated as a diagnostic marker for tumour progression in non-functional adenomas, to distinguish atypical from benign tumours. ..
  45. Azhari S, Mlahi M, Mostafa M. Comparative studies between 4-allyl-, 4-phenyl- and 4-ethyl-1-(2-hydroxybenzoyl) thiosemicarbazides and the synthesis, characterization and DFT calculations of binary and ternary complexes derived from 4-ethyl (L(1)) and 2,2'-dipyridyl. Spectrochim Acta A Mol Biomol Spectrosc. 2015;150:949-58 pubmed publisher
    ..Also, the MEP for L(1) is illustrated...
  46. Cassidy J, Carey J, Lu C, Krach L, Feyma T, Durfee W, et al. Ipsilesional motor-evoked potential absence in pediatric hemiparesis impacts tracking accuracy of the less affected hand. Res Dev Disabil. 2015;47:154-64 pubmed publisher
    ..Nineteen participants demonstrating an ipsilesional motor-evoked potential (MEP) were compared with eleven participants showing an absent ipsilesional MEP response...
  47. Percy Z, Xu Y, Sucharew H, Khoury J, Calafat A, Braun J, et al. Gestational exposure to phthalates and gender-related play behaviors in 8-year-old children: an observational study. Environ Health. 2016;15:87 pubmed publisher
    ..For the dichotomized PPPSI; higher maternal monoethyl phthalate (MEP) concentrations were associated with more typical play behaviors for females (OR?=?0.70, CI?=?0.51-0.97)...
  48. Perrio C, Schmitt S, Pla D, Gabbaï F, Chansaenpak K, Mestre Voegtlé B, et al. [18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane. Chem Commun (Camb). 2016;53:340-343 pubmed publisher
    ..trapping of aqueous [18F]-fluoride on a cartridge pre-loaded with the phosphonium borane [(Ph2MeP)C6H4(BMes2)]+, then releasing by elution of TBACN in dry acetonitrile...
  49. Tatemoto T, Tsuchiya J, Numata A, Osawa R, Yamaguchi T, Tanabe S, et al. Real-time changes in corticospinal excitability related to motor imagery of a force control task. Behav Brain Res. 2017;335:185-190 pubmed publisher
    ..The MEP ratio, as the ratio of imaged MEPs to resting-state, was compared between pre- and post-training at each time point...
  50. Caserman S, Kenig S, Sloane B, Lah T. Cathepsin L splice variants in human breast cell lines. Biol Chem. 2006;387:629-34 pubmed
    Transcripts of the lysosomal cysteine proteinase cathepsin L are spliced into five variants (L-A, L-A1, LA-2, LA-3 and L-B), which have similar stabilities but different translation efficiencies, thus potentially yielding diverse amounts ..
  51. Merhi A, De Mees C, Abdo R, Victoria Alberola J, Marini A. Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells. PLoS ONE. 2015;10:e0128683 pubmed publisher
    ..Transmembrane ammonium transport is a widely spread process ensured by the highly conserved proteins of the Mep-Amt-Rh superfamily, including the mammalian Rhesus (Rh) factors...
  52. Thirugnanasambandam N, Khera R, Wang H, Kukke S, Hallett M. Distinct interneuronal networks influence excitability of the surround during movement initiation. J Neurophysiol. 2015;114:1102-8 pubmed publisher
    ..The motor evoked potential (MEP) amplitudes were then plotted against stimulation intensities to obtain the MEP recruitment curves for the rest and ..
  53. Dong Q, Brenneman B, Fields C, Srivastava A. A Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster. FEBS Lett. 2015;589:3090-7 pubmed publisher
    ..Our data provide clues to the possible role of Cathepsin L in human lung development and tumor invasion, especially, given the similarities between human lung and ..
  54. Yang J, Liu H, Zheng G, Xiang X, Lv Z, Wang T. Cathepsin L of the sea cucumber Apostichopus japonicus-molecular characterization and transcriptional response to Vibrio splendidus infection. Fish Shellfish Immunol. 2016;49:387-95 pubmed publisher
    b>Cathepsin L, a lysosomal endopeptidase, has been noted for its involvement in the innate immune response in invertebrates...
  55. Boels M, van Faassen E, Avramut M, van der Vlag J, van den Berg B, Rabelink T. Direct Observation of Enhanced Nitric Oxide in a Murine Model of Diabetic Nephropathy. PLoS ONE. 2017;12:e0170065 pubmed publisher
    ..This was confirmed by unaltered increased glomerular presence of cathepsin L, the protease that activates heparanase.
  56. Klaude M, Mori M, Tjader I, Gustafsson T, Wernerman J, Rooyackers O. Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis. Clin Sci (Lond). 2012;122:133-42 pubmed publisher
    ..In conclusion, the dramatic muscle wasting seen in critically ill patients with sepsis is due to increased protein degradation. This is facilitated by increased activities of both the proteasome and lysosomal proteolytic systems. ..
  57. Bhutani N, Piccirillo R, Hourez R, Venkatraman P, Goldberg A. Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes. J Biol Chem. 2012;287:17471-82 pubmed publisher
    ..g. mutant SOD1). Therefore, the activities of these two lysosomal cysteine proteases are important in host defense against toxic accumulation of polyQ proteins. ..
  58. Dicheva B, Seynhaeve A, Soulie T, Eggermont A, ten Hagen T, Koning G. Pharmacokinetics, Tissue Distribution and Therapeutic Effect of Cationic Thermosensitive Liposomal Doxorubicin Upon Mild Hyperthermia. Pharm Res. 2016;33:627-38 pubmed publisher
    ..CTSL have potency to increase drug efficacy in tumors due to their targeted and drug release functions. ..
  59. Ma Z, Zhang Y, Liu W, Yan G, Li Y, Shields L, et al. A controlled spinal cord contusion for the rhesus macaque monkey. Exp Neurol. 2016;279:261-273 pubmed publisher
    ..Multiple assessments including motor-evoked potential (MEP), somatosensory-evoked potential (SSEP), MR imaging, and monkey hindlimb score (MHS) were performed...
  60. Pinto S, Alves P, Swash M, de Carvalho M. Phrenic nerve stimulation is more sensitive than ultrasound measurement of diaphragm thickness in assessing early ALS progression. Neurophysiol Clin. 2017;47:69-73 pubmed publisher
    ..forced vital capacity (FVC), maximal voluntary ventilation (MVV), maximal inspiratory (MIP) and expiratory (MEP) pressures, sniff nasal inspiratory pressure (SNIP), Diaphragm-CMAP (latency and amplitude) and diaphragm US (..
  61. Li J, Jiang J, Pang S, Zhou Y, Gao Y, Yang Y, et al. Transformation of Methylparaben by aqueous permanganate in the presence of iodide: Kinetics, modeling, and formation of iodinated aromatic products. Water Res. 2018;135:75-84 pubmed publisher
    ..impacts of iodide (I-) on the transformation of the widely used phenolic preservative methylparaben (MeP) as well as 11 other phenolic compounds by potassium permanganate (KMnO4)...
  62. Magister S, Obermajer N, Mirković B, Svajger U, Renko M, Softić A, et al. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells. Eur J Cell Biol. 2012;91:391-401 pubmed publisher
    ..After induction of DC maturation however, it is translocated into lysosomes and colocalizes with cathepsin L. The inhibitory potential of cystatin F depends on the properties of the monomer...
  63. Boeckstaens M, Merhi A, Llinares E, Van Vooren P, Springael J, Wintjens R, et al. Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32. PLoS Genet. 2015;11:e1005382 pubmed publisher
    ..In yeast, it is a preferred nitrogen source transported by three Mep proteins which are orthologues of the mammalian Rhesus factors...
  64. TURNER J, Eastlack R, Mirzadeh Z, Nguyen S, Pawelek J, Mundis G. Fluctuations in Spinal Cord Perfusion During Adult Spinal Deformity Correction Identify Neurologic Changes: Proof of Concept. World Neurosurg. 2016;85:365.e1-6 pubmed publisher
    ..Somatosensory evoked potential (SSEP) and motor evoked potential (MEP) were monitored throughout the case...
  65. Opie G, Rogasch N, Goldsworthy M, Ridding M, Semmler J. Investigating TMS-EEG Indices of Long-Interval Intracortical Inhibition at Different Interstimulus Intervals. Brain Stimul. 2017;10:65-74 pubmed publisher
    ..that is not subject to variations in spinal cord excitability that can confound the motor evoked potential (MEP). In 12 subjects (22.6 ± 0...
  66. da Rosa G, Morcillo A, de Assumpção M, Schivinski C. Predictive equations for maximal respiratory pressures of children aged 7-10. Braz J Phys Ther. 2017;21:30-36 pubmed publisher
    ..577+0.006×weight (kg) (R2aj=14.1%) and Log(MEP)=1.282+0.409×height (m) (R2aj=13.9%); and for girls: Log(MIP)=1.548+0...
  67. De Sousa L, Wu H, Nebo L, Fernandes J, da Silva M, Kiefer W, et al. Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana. Exp Parasitol. 2015;156:42-8 pubmed publisher
    ..are promising molecular targets against leishmaniasis. Leishmania mexicana cathepsin L is essential in the parasite life cycle and a pivotal in virulence factor in mammals...
  68. Kraus D, Naros G, Bauer R, Leão M, Ziemann U, Gharabaghi A. Brain-robot interface driven plasticity: Distributed modulation of corticospinal excitability. Neuroimage. 2016;125:522-532 pubmed publisher
    ..of this BRI intervention were probed by acquiring the stimulus-response curve (SRC) of both motor evoked potential (MEP) peak-to-peak amplitudes and areas under the curve. In addition, a motor mapping was obtained...
  69. Wang I, Karmaus W. Oxidative Stress-Related Genetic Variants May Modify Associations of Phthalate Exposures with Asthma. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..study composed of 126 asthmatic children and 327 controls, urine phthalate metabolites (monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), and mono(2-ethyl-5-hydroxyhexyl)phthalate (MEHHP) were ..
  70. Zhang Y, Gao H, Mao L, Tao X, Ge X, Huang K, et al. Effects of the phthalate exposure during three gestation periods on birth weight and their gender differences: A birth cohort study in China. Sci Total Environ. 2018;613-614:1573-1578 pubmed publisher
    ..Phthalate metabolites included monomethyl phthalate (MMP), monoethyl phthalate (MEP), mono-n-butyl phthalate (MBP), monobenzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-..
  71. Spötter A, Drogemuller C, Kuiper H, Brenig B, Leeb T, Distl O. Characterization and comparative mapping of the porcine CTSL gene indicates a novel synteny between HSA9q21-->q22 and SSC10q11-->q12. Cytogenet Cell Genet. 2001;95:92-6 pubmed
    b>Cathepsin L (CTSL) is a lysosomal cysteine protease with potent elastase and collagenase activities...
  72. Sienkiewicz Gromiuk J. DFT approach to (benzylthio)acetic acid: Conformational search, molecular (monomer and dimer) structure, vibrational spectroscopy and some electronic properties. Spectrochim Acta A Mol Biomol Spectrosc. 2018;189:116-128 pubmed publisher
    ..Additionally, the MEP and ESP surfaces were computed to predict coordination sites for potential metal complex formation.
  73. Dai L, Chu S, Yu X, Li Y. A role of cathepsin L gene in innate immune response of crayfish (Procambarus clarkii). Fish Shellfish Immunol. 2017;71:246-254 pubmed publisher
    b>Cathepsin L is one of the crucial enzyme superfamilies and involved in the immune responses. In the present study, cathepsin L gene from the red crayfish Procambarus clarkii, named PcCTSL, was cloned and characterized...
  74. Wang J, Liu Y, Li X, Peng D, Tan Z, Liu H, et al. [Association of cathepsin L with coronary heart disease and its risk factors]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:130-4 pubmed
    To explore the relationship of cathepsin L (CatL) with coronary heart disease (CHD), severity of coronary stenosis and risk factors of CHD...
  75. Adams Cioaba M, Krupa J, Xu C, Mort J, Min J. Structural basis for the recognition and cleavage of histone H3 by cathepsin L. Nat Commun. 2011;2:197 pubmed publisher
    ..The recruitment of lysosomal cathepsin L to the nucleus where it mediates proteolysis of the mouse histone H3 tail has been described recently...
  76. Wyczałkowska Tomasik A, Paczek L. Cathepsin B and L activity in the serum during the human aging process: cathepsin B and L in aging. Arch Gerontol Geriatr. 2012;55:735-8 pubmed publisher
    ..Fluorometric assay was used to determine proteolytic enzyme activity. Cathepsin B and L activity was measured as a total activity. The activity of cathepsin B and L significantly increases with age. ..
  77. Sage J, Leblanc Noblesse E, Nizard C, Sasaki T, Schnebert S, Perrier E, et al. Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners. PLoS ONE. 2012;7:e43494 pubmed publisher
  78. Yamashita T, Asano Y, Taniguchi T, Nakamura K, Saigusa R, Takahashi T, et al. A potential contribution of altered cathepsin L expression to the development of dermal fibrosis and vasculopathy in systemic sclerosis. Exp Dermatol. 2016;25:287-92 pubmed publisher
    b>Cathepsin L (CTSL) is a lysosomal proteolytic enzyme involved in inflammation and vascular and extracellular matrix remodelling, which are the three cardinal pathological events associated with systemic sclerosis (SSc)...
  79. Akhtar M, Qamar N, Yadav P, Kulkarni P, Kumar A, Shasany A. Comparative glandular trichome transcriptome-based gene characterization reveals reasons for differential (-)-menthol biosynthesis in Mentha species. Physiol Plant. 2017;160:128-141 pubmed publisher
    ..In addition to the mevalonic acid (MVA) and methylerythritol phosphate (MEP) pathway genes, about 210 and 196 different terpene synthases (TPSs) transcripts were identified from annotation in ..
  80. Uhlman A, Folkers K, Liston J, Pancholi H, Hinton A. Effects of Vacuolar H+-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells. Cancer Microenviron. 2017;10:49-56 pubmed publisher
    ..We investigated whether V-ATPase inhibition would reduce the activity of secreted cathepsin B and cathepsin L. Using cell lysates and conditioned media, we measured cathepsin B and L activity within and outside of the ..
  81. Novinec M. Computational investigation of conformational variability and allostery in cathepsin K and other related peptidases. PLoS ONE. 2017;12:e0182387 pubmed publisher
    ..We show that human cathepsin L-like endopeptidases (cathepsins L, K, S and V) adopt similar conformations which are distinct from their non-..
  82. Borel F, Barbier E, Krasutsky S, Janthawornpong K, Chaignon P, Poulter C, et al. Further Insight into Crystal Structures of Escherichia coli IspH/LytB in Complex with Two Potent Inhibitors of the MEP Pathway: A Starting Point for Rational Design of New Antimicrobials. Chembiochem. 2017;18:2137-2144 pubmed publisher
    ..95 and 1.7?Å resolution, respectively. The structure of the E.?coli IspH:TMBPP complex exhibited two conformers of the inhibitor. This unexpected feature was exploited to design and evolve new antimicrobial candidates in silico...
  83. Kumar B, Manjunathachar H, Nagar G, Ravikumar G, de la Fuente J, Saravanan B, et al. Functional characterization of candidate antigens of Hyalomma anatolicum and evaluation of its cross-protective efficacy against Rhipicephalus microplus. Vaccine. 2017;35:5682-5692 pubmed publisher
    ..The subolesin (SUB), calreticulin (CRT) and cathepsin L-like cysteine proteinase (CathL) genes of H...
  84. Estrada S, Nycander M, Hill N, Craven C, Waltho J, Bjork I. The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L. Biochemistry. 1998;37:7551-60 pubmed
    ..resulted in approximately 1000-, approximately 10- and approximately 6000-fold decreased affinities for papain, cathepsin L, and cathepsin B, respectively...
  85. Michallet M, Saltel F, Flacher M, Revillard J, Genestier L. Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance. J Immunol. 2004;172:5405-14 pubmed
    ..E64d, a cysteine protease inhibitor, as well as specific inhibitors of cathepsin B and cathepsin L conferred protection...
  86. Soukenik M, Diehl A, Leidert M, Sievert V, Büssow K, Leitner D, et al. The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L. FEBS Lett. 2004;576:358-62 pubmed
    ..The SEP domain was found to be a reversible competitive inhibitor of cathepsin L with a Ki of 1.5 microM...
  87. Dawson K, Zhao L, Adkins Y, Vemuri M, Rodriguez R, Gregg J, et al. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. J Nutr Biochem. 2012;23:616-21 pubmed publisher
    ..that DHA supplementation significantly suppressed the expression of low-density lipoprotein (LDL) receptor and cathepsin L1, both of which were also up-regulated by LPS...
  88. Ishii T, Abboud R, Wallace A, English J, Coxson H, Finley R, et al. Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema. Eur Respir J. 2014;43:82-91 pubmed publisher
    ..The basal expression of MMP1 mRNA was positively correlated with the extent of emphysema. Cathepsin L protein level was positively associated with forced expiratory volume in 1 s % predicted...
  89. Zhang Q, Han M, Wang W, Song Y, Chen G, Wang Z, et al. Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor‑β‑mediated epithelial‑mesenchymal transition. Oncol Rep. 2015;33:1851-9 pubmed publisher
    b>Cathepsin L, a lysosomal acid cysteine protease, was found to be overexpressed in several types of human carcinomas. However, its functional roles in tumor progression and the underlying mechanisms remain largely unclear...
  90. Wang W, Long L, Wang L, Tan C, Fei X, Chen L, et al. Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro. Cancer Lett. 2016;371:274-84 pubmed publisher
    ..This study assessed whether knockdown of Cathepsin L can influence GSC growth, tumor radiosensitivity, and clinical outcome...
  91. Federico P, Perez M. Distinct Corticocortical Contributions to Human Precision and Power Grip. Cereb Cortex. 2017;27:5070-5082 pubmed publisher
    ..We found that AP-LM MEP latency differences were consistently longer during power grip compared with index finger abduction and precision ..
  92. Zhou X, Paushter D, Feng T, Sun L, Reinheckel T, Hu F. Lysosomal processing of progranulin. Mol Neurodegener. 2017;12:62 pubmed publisher
    ..We further demonstrated that multiple cathepsins are involved in PGRN processing and cathepsin L cleaves PGRN in vitro...