cathepsin D

Summary

Gene Symbol: cathepsin D
Description: cathepsin D
Alias: CLN10, CPSD, HEL-S-130P, cathepsin D, ceroid-lipofuscinosis, neuronal 10, epididymis secretory sperm binding protein Li 130P, lysosomal aspartyl peptidase, lysosomal aspartyl protease
Species: human
Products:     cathepsin D

Top Publications

  1. Berchem G, Glondu M, Gleizes M, Brouillet J, Vignon F, Garcia M, et al. Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis. Oncogene. 2002;21:5951-5 pubmed
    ..Our overall results provide the first mechanistic evidences on the essential role of cathepsin-D at multiple tumor progression steps, affecting cell proliferation, angiogenesis and apoptosis. ..
  2. Hu L, Roth J, Brooks P, Luty J, Karpatkin S. Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis. Cancer Res. 2008;68:4666-73 pubmed publisher
    b>Cathepsin D (CD) up-regulation has been associated with human malignancy and poor prognosis. Thrombin up-regulated CD mRNA and protein in eight tumor cell lines as well as in human umbilical vascular endothelial cells (HUVEC)...
  3. Mateo I, Sanchez Guerra M, Combarros O, Llorca J, Infante J, González García J, et al. Lack of association between cathepsin D genetic polymorphism and Alzheimer disease in a Spanish sample. Am J Med Genet. 2002;114:31-3 pubmed
    b>Cathepsin D (catD) is an intracellular aspartyl protease that exhibits beta and gamma secretase-like activity to cleave amyloid precursor protein into beta amyloid peptide...
  4. Glondu M, Coopman P, Laurent Matha V, Garcia M, Rochefort H, Liaudet Coopman E. A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells. Oncogene. 2001;20:6920-9 pubmed
    ..Our results altogether demonstrate that a mutated cathepsin-D devoid of catalytic activity is still mitogenic and suggest that it is acting extra-cellularly by triggering directly or indirectly a yet unidentified cell surface receptor. ..
  5. Sun Y, Shi J, Zhang S, Tang M, Han H, Guo Y, et al. [The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese]. Yi Chuan. 2005;27:190-4 pubmed
    b>Cathepsin D is the major lysosomal/endosomal aspartic protease and exhibits beta- and gamma-secretase-like activity in vitro...
  6. Menzer G, Müller Thomsen T, Meins W, Alberici A, Binetti G, Hock C, et al. Non-replication of association between cathepsin D genotype and late onset Alzheimer disease. Am J Med Genet. 2001;105:179-82 pubmed
    ..the allelic variant T of the amino acid substitution encoding polymorphism 224 C/T (A38V) in exon 2 of the cathepsin D gene (CTSD) and late onset Alzheimer disease (AD)...
  7. Schuur M, Ikram M, van Swieten J, Isaacs A, Vergeer Drop J, Hofman A, et al. Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis. Neurobiol Aging. 2011;32:1607-14 pubmed publisher
    b>Cathepsin D (CTSD) is a gene involved in amyloid precursor protein processing and is considered a candidate for Alzheimer's disease (AD). The aim of the current study was to examine if variation in CTSD increases the risk of AD...
  8. Liaudet Coopman E, Beaujouin M, Derocq D, Garcia M, Glondu Lassis M, Laurent Matha V, et al. Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis. Cancer Lett. 2006;237:167-79 pubmed
    The lysosomal aspartic protease cathepsin D (cath-D) is over-expressed and hyper-secreted by epithelial breast cancer cells...
  9. Glondu M, Liaudet Coopman E, Derocq D, Platet N, Rochefort H, Garcia M. Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells. Oncogene. 2002;21:5127-34 pubmed
    ..Our overall results provide the first evidence on the essential role of cathepsin-D in breast cancer, and support the development of a new cathepsin-D-targeted therapy. ..

More Information

Publications77

  1. Capurso C, Solfrizzi V, D Introno A, Colacicco A, Capurso S, Bifaro L, et al. Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms. Neurosci Lett. 2008;432:237-42 pubmed publisher
    Catalase (CAT) -262 C/T promoter (rs1001179), cathepsin D (CTSD) exon 2 (rs17571), and apolipoprotein E (APOE) gene polymorphisms were studied in 242 patients with sporadic Alzheimer's disease (AD) and 421 unrelated age-, sex-, and ..
  2. Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, et al. Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype. J Neurol Neurosurg Psychiatry. 2006;77:515-7 pubmed
    ..It has been suggested that the C-->T (224Ala-->Val) transition within exon 2 of the cathepsin D gene (CTSD) might represent a risk factor for late onset AD...
  3. Carew J, Espitia C, Esquivel J, Mahalingam D, Kelly K, Reddy G, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011;286:6602-13 pubmed publisher
    ..Microarray analysis, qRT-PCR, and immunoblotting determined that lucanthone stimulated a large induction in cathepsin D, which correlated with cell death. Accordingly, knockdown of cathepsin D reduced lucanthone-mediated apoptosis...
  4. Bidere N, Lorenzo H, Carmona S, Laforge M, Harper F, Dumont C, et al. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem. 2003;278:31401-11 pubmed
    ..This allowed us to define a novel sequence of events in which Cat D triggers Bax activation, Bax induces the selective release of mitochondrial AIF, and the latter is responsible for the early apoptotic phenotype. ..
  5. El Messaoudi K, Thiry L, Liesnard C, Van Tieghem N, Bollen A, Moguilevsky N. A human milk factor susceptible to cathepsin D inhibitors enhances human immunodeficiency virus type 1 infectivity and allows virus entry into a mammary epithelial cell line. J Virol. 2000;74:1004-7 pubmed
    ..The enhancing effect of milk was abolished by anti-cathepsin D antibody or by pepstatin A, a cathepsin D inhibitor...
  6. Laurent Matha V, Maruani Herrmann S, Prébois C, Beaujouin M, Glondu M, Noel A, et al. Catalytically inactive human cathepsin D triggers fibroblast invasive growth. J Cell Biol. 2005;168:489-99 pubmed
    The aspartyl-protease cathepsin D (cath-D) is overexpressed and hypersecreted by epithelial breast cancer cells and stimulates their proliferation...
  7. Appelqvist H, Johansson A, Linderoth E, Johansson U, Antonsson B, Steinfeld R, et al. Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at Phe24, Trp48, and Phe183. Ann Clin Lab Sci. 2012;42:231-42 pubmed
    ..This report identifies proteolytically active cathepsin D as an important component of apoptotic signaling following lysosomal membrane permeabilization in fibroblasts...
  8. Prince J, Feuk L, Sawyer S, Gottfries J, Ricksten A, Nagga K, et al. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. Eur J Hum Genet. 2001;9:437-44 pubmed
    ..1 (PSEN1), presenilin 2 (PSEN2), butyrylcholinesterase (BCHE), Fe65 (APBB1), oestrogen receptor alpha (ESR1), cathepsin D (CTSD), methylenetetrahydrofolate reductase (MTHFR), and interleukin 1A (IL1A)...
  9. Ingegni T, Nocentini G, Mariani E, Spazzafumo L, Polidori M, Cherubini A, et al. Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease. Dement Geriatr Cogn Disord. 2003;16:151-5 pubmed
    ..It has been suggested that the cathepsin D gene (CTSD) is associated with late-onset AD...
  10. Byun H, Han N, Lee H, Kim K, Ko Y, Yoon G, et al. Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. Cancer Res. 2009;69:4638-47 pubmed publisher
    ..IR-induced senescence was associated with up-regulation of cathepsin D (CD) and down-regulation of eukaryotic translation elongation factor 1beta2 (eEF1B2), as confirmed by Western ..
  11. Ntais C, Polycarpou A, Ioannidis J. Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review. Am J Epidemiol. 2004;159:527-36 pubmed
    A C-to-T polymorphism in exon 2 of the cathepsin D gene encoding cathepsin D (CTSD) has been implicated as a risk factor for Alzheimer's disease...
  12. Bertram L, Guenette S, Jones J, Keeney D, Mullin K, Crystal A, et al. No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease. Ann Neurol. 2001;49:114-6 pubmed
    Two recent case-control studies have suggested a strong association of a missense polymorphism in exon 2 of the cathepsin D gene (CTSD) and Alzheimer disease (AD). However, these findings were not confirmed in another independent study...
  13. Papassotiropoulos A, Bagli M, Kurz A, Kornhuber J, Forstl H, Maier W, et al. A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease. Ann Neurol. 2000;47:399-403 pubmed
    b>Cathepsin D (catD) is an intracellular acid protease possibly involved in Alzheimer's disease (AD)-related neurodegeneration through cleavage of amyloid precursor protein into amyloidogenic components...
  14. Sadik G, Kaji H, Takeda K, Yamagata F, Kameoka Y, Hashimoto K, et al. In vitro processing of amyloid precursor protein by cathepsin D. Int J Biochem Cell Biol. 1999;31:1327-37 pubmed
    ..Several lines of evidence suggest that cathepsin D, the major lysosomal/endosomal aspartic protease, may be involved in this process...
  15. Conus S, Pop C, Snipas S, Salvesen G, Simon H. Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis. J Biol Chem. 2012;287:21142-51 pubmed publisher
    ..A direct and fast activation of caspase-8 by cathepsin D was shown to be crucial in the initial steps of neutrophil apoptosis...
  16. Hah Y, Noh H, Ha J, Ahn J, Hahm J, Cho H, et al. Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells. Cancer Lett. 2012;323:208-14 pubmed publisher
    b>Cathepsin D (CatD), a lysosomal aspartic protease, plays an essential role in tumor progression and apoptosis. However, the function of CatD in cell death is not yet fully understood...
  17. Ohri S, Vashishta A, Proctor M, Fusek M, Vetvicka V. The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. Int J Oncol. 2008;32:491-8 pubmed
    ..Our study concludes that the entire 27-44 amino acid region of AP is necessary for the stimulatory actions of pCD on breast cancer cells. ..
  18. Capurso C, Solfrizzi V, D Introno A, Colacicco A, Capurso S, Mastroianni F, et al. The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations. J Gerontol A Biol Sci Med Sci. 2005;60:991-6 pubmed
    The cathepsin D gene (CTSD) exon 2 (C224T) polymorphism has been associated with an increased risk for sporadic Alzheimer's disease (AD), but with controversial findings...
  19. Capony F, Rougeot C, Montcourrier P, Cavailles V, Salazar G, Rochefort H. Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells. Cancer Res. 1989;49:3904-9 pubmed
    In human mammary cancer cells, pro-cathepsin D (pro-Cath-D) is induced by estrogens and 50% of it is secreted...
  20. Corder E, Huang R, Cathcart H, Lanham I, Parker G, Cheng D, et al. Membership in genetic groups predicts Alzheimer disease. Rejuvenation Res. 2006;9:89-93 pubmed
    ..statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls)...
  21. Cullen V, Lindfors M, Ng J, Paetau A, Swinton E, Kolodziej P, et al. Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Mol Brain. 2009;2:5 pubmed publisher
    ..Here, we explore the effects of CTSD gene expression, which encodes the lysosomal protease cathepsin D (CathD), on aSyn processing. Over-expression of human CTSD cDNA in dopaminergic MES23...
  22. Payton A, Holland F, Diggle P, Rabbitt P, Horan M, Davidson Y, et al. Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Mol Psychiatry. 2003;8:14-8 pubmed
    ..we report the finding of another QTL associated with general intelligence that is located within exon 2 of the cathepsin D (CTSD) gene...
  23. Yu B, Fonseca D, O Rourke S, Berman P. Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sites. J Virol. 2010;84:1513-26 pubmed publisher
    ..These results suggested that HIV may have evolved to take advantage of major histocompatibility complex (MHC) class II antigen processing enzymes in order to evade or direct the antiviral immune response. ..
  24. Albayrak O, Tirniceriu A, Riemenschneider M, Kurz A, Scherag A, Egensperger R. The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men. J Gerontol A Biol Sci Med Sci. 2010;65:219-24 pubmed publisher
    The lysosomal protease cathepsin D is likely involved in beta-amyloidogenesis in Alzheimer's disease (AD). There is evidence for a single nucleotide polymorphism (rs17571) of the cathepsin D gene to be associated with increased AD risk...
  25. Melzer I, Fernández S, Bosser S, Lohrig K, Lewandrowski U, Wolters D, et al. The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potential. Cell Death Differ. 2012;19:1435-45 pubmed publisher
    ..Furthermore, we identify Cathepsin D (CathD) as the protease responsible for Aven cleavage...
  26. Sevlever D, Jiang P, Yen S. Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species. Biochemistry. 2008;47:9678-87 pubmed publisher
    ..In this study, the role of cathepsin D and calpain I in these processes was analyzed...
  27. Pimenta D, Oliveira A, Juliano M, Juliano L. Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin. Biochim Biophys Acta. 2001;1544:113-22 pubmed
    ..human tissue kallikrein, was demonstrated to be cleaved at the Phe-Phe bond in its reactive site loop (RSL) by cathepsin D. Internally quenched fluorescent peptides containing the amino acid sequence of kallistatin RSL were highly ..
  28. Mariani E, Seripa D, Ingegni T, Nocentini G, Mangialasche F, Ercolani S, et al. Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease. J Neurol Sci. 2006;247:187-91 pubmed
    The proteins cathepsin D, encoded by CTSD gene, and alpha2-macroglobulin, encoded by A2M gene, are involved in the biochemical pathway leading to deposition of beta-amyloid...
  29. Beaujouin M, Prébois C, Derocq D, Laurent Matha V, Masson O, Pattingre S, et al. Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth. J Cell Sci. 2010;123:3336-46 pubmed publisher
    ..We have previously shown that the aspartic protease cathepsin D (cath-D), a marker of poor prognosis in breast cancer that is overexpressed and highly secreted by breast ..
  30. Steinfeld R, Reinhardt K, Schreiber K, Hillebrand M, Kraetzner R, Bruck W, et al. Cathepsin D deficiency is associated with a human neurodegenerative disorder. Am J Hum Genet. 2006;78:988-98 pubmed
    b>Cathepsin D is a ubiquitously expressed lysosomal protease that is involved in proteolytic degradation, cell invasion, and apoptosis. In mice and sheep, cathepsin D deficiency is known to cause a fatal neurodegenerative disease...
  31. Riemenschneider M, Blennow K, Wagenpfeil S, Andreasen N, Prince J, Laws S, et al. The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease. Hum Mutat. 2006;27:532-7 pubmed
    The lysosomal protease cathepsin D (CtsD, EC 3.4.23...
  32. Beaujouin M, Baghdiguian S, Glondu Lassis M, Berchem G, Liaudet Coopman E. Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity. Oncogene. 2006;25:1967-73 pubmed
    The aspartic protease cathepsin D (cath-D) is a key mediator of induced-apoptosis and its proteolytic activity has been generally involved in this event. During apoptosis, cath-D is translocated to the cytosol...
  33. Li X, Chen D, Zhang Z, Qu Q, Zhang J. Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population. Dement Geriatr Cogn Disord. 2004;18:115-9 pubmed
    b>Cathepsin D (CTSD) is an intracellular aspartyl protease, which is active in the endosomal/lysosomal system...
  34. Metcalf P, Fusek M. Two crystal structures for cathepsin D: the lysosomal targeting signal and active site. EMBO J. 1993;12:1293-302 pubmed
    Two crystal structures are described for the lysosomal aspartic protease cathepsin D (EC 3.4.23.5)...
  35. Styczynska M, Religa D, Pfeffer A, Luczywek E, Wasiak B, Styczynski G, et al. Simultaneous analysis of five genetic risk factors in Polish patients with Alzheimer's disease. Neurosci Lett. 2003;344:99-102 pubmed
    ..Five candidate genes were chosen: apolipoprotein E (APOE), alpha 2-macroglobulin, cathepsin D, myeloperoxidase and nitric oxide synthase...
  36. Papassotiropoulos A, Lewis H, Bagli M, Jessen F, Ptok U, Schulte A, et al. Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene. Neuroreport. 2002;13:1291-4 pubmed
    The intracellular aspartyl protease cathepsin D (catD) is involved in such Alzheimer's disease (AD)-related processes as the activation of the endosomal/lysosomal system and the cleavage of the amyloid precursor protein into ..
  37. Bagnoli S, Nacmias B, Tedde A, Guarnieri B, Cellini E, Ciantelli M, et al. Cathepsin D polymorphism in Italian sporadic and familial Alzheimer's disease. Neurosci Lett. 2002;328:273-6 pubmed
    A recent study has shown that a genetic variation in the Cathepsin D (catD) gene is a major risk factor for the development of Alzheimer's disease (AD). CatD is an intracellular aspartyl protease involved in neurodegeneration...
  38. Chang B, Kim D, Kim H, Kim S. Evaluation of estrogenic potential by herbal formula, HPC 03 for in vitro and in vivo. Reproduction. 2018;155:105-115 pubmed publisher
    ..HPC 03 may be a promising candidate for the treatment of menopause, but further research is necessary to determine whether the observed effects also occur in humans. ..
  39. Heun R, Ptok U, Kolsch H, Maier W, Jessen F. Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease. Dement Geriatr Cogn Disord. 2004;18:151-8 pubmed
    ..Relatives of nondemented controls with an apolipoprotein E4 or a cathepsin D T allele had a higher cumulative lifetime incidence of AD than relatives of subjects without the respective ..
  40. Pruitt F, He Y, Franco O, Jiang M, Cates J, Hayward S. Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium. Prostate. 2013;73:476-88 pubmed publisher
    ..We investigated whether stromal cathepsin D (CathD) overexpression affects prostate tumorigenesis through a paracrine mechanism...
  41. Westley B, May F. Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells. Nucleic Acids Res. 1987;15:3773-86 pubmed
    ..reading frame and 3' non-coding region of the mRNA was determined and shown to encode the aspartyl protease cathepsin D. The induction of cathepsin D mRNA is specific for oestrogen and is maximal at 3 X 10(-10) M...
  42. Xie L, Zhao C, Cai S, Xu Y, Huang L, Bian J, et al. Novel proteomic strategy reveal combined alpha1 antitrypsin and cathepsin D as biomarkers for colorectal cancer early screening. J Proteome Res. 2010;9:4701-9 pubmed publisher
    ..Two glycol-proteins, alpha1 antitrypsin (A1AT) and cathepsin D (CTSD), which play central role in proteasome regulation, were further examined due to their possible ..
  43. Morikawa W, Yamamoto K, Ishikawa S, Takemoto S, Ono M, Fukushi J, et al. Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells. J Biol Chem. 2000;275:38912-20 pubmed
    ..The purified procathepsin D, as well as cathepsin D, generated two angiostatic peptides having the same NH(2)-terminal amino acid sequences and comprising kringles ..
  44. Venkanna A, Kwon O, Afzal S, Jang C, Cho K, Yadav D, et al. Pharmacological use of a novel scaffold, anomeric N,N-diarylamino tetrahydropyran: molecular similarity search, chemocentric target profiling, and experimental evidence. Sci Rep. 2017;7:12535 pubmed publisher
  45. Molnár B, Fodor B, Csámpai A, Hidvégi E, Molnár Perl I. Structure-related related new approach in the gas chromatography/mass spectrometry analysis of cathinone type synthetic drugs. J Chromatogr A. 2016;1477:70-75 pubmed publisher
    ..The instantenous combination of the primarily formed, characteristic fragments with the mass m/z 44, led to the special equilibrium of products: confirming that direct trimethylsilylation of CTSDs is not suitable for their quantitation. ..
  46. Brujan I, Mărgăritescu C, Simionescu C, Pirici D, Fronie A, Foarfă C, et al. Cathepsin-D expression in breast lesion: an immunohistochemical study. Rom J Morphol Embryol. 2009;50:31-9 pubmed
    ..We also conclude that our procedure in IOD measurement is prone to less subjective-related biases, and thus more accurate and constant than other methods employed by other authors. ..
  47. Hilfiker Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, et al. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell. 2007;128:589-600 pubmed
    ..In these mice, cardiac cathepsin D (CD) expression and activity is enhanced and associated with the generation of a cleaved antiangiogenic and ..
  48. Fan C, Lin X, Wang E. Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study. Tumour Biol. 2012;33:1045-52 pubmed
    b>Cathepsin D is a well-known peptidase which belongs to the family of aspartic peptidases. It has been found to be overexpressed in many malignant tumors and associated with cancer metastasis and clinical outcome...
  49. Higaki J, Catalano R, Guzzetta A, Quon D, Nave J, Tarnus C, et al. Processing of beta-amyloid precursor protein by cathepsin D. J Biol Chem. 1996;271:31885-93 pubmed
    ..We investigated the role of cathepsin D in the processing of betaAPP since this enzyme has been widely proposed as a gamma-secretase candidate...
  50. Grangeasse C. Rewiring the Pneumococcal Cell Cycle with Serine/Threonine- and Tyrosine-kinases. Trends Microbiol. 2016;24:713-724 pubmed publisher
    ..In this review, I survey the role of the only two serine/threonine- (StkP) and tyrosine-kinases (CpsD) of the pneumococcus and discuss the existence of interconnected phosphorylation networks coordinating cell ..
  51. Chandra G, Bagh M, Peng S, Saha A, Sarkar C, Moralle M, et al. Cln1 gene disruption in mice reveals a common pathogenic link between two of the most lethal childhood neurodegenerative lysosomal storage disorders. Hum Mol Genet. 2015;24:5416-32 pubmed publisher
    ..in the CLN1 gene encoding palmitoyl-protein thioesterase-1 (PPT1) cause INCL, those in the CLN10 gene encoding cathepsin D (CD) underlie CNCL...
  52. Kim H, Lee M, Kang H, Moon C. Cathepsin D levels are reduced in patients with preeclampsia in Korean population. Clin Biochem. 2013;46:1808-11 pubmed publisher
    To compare the circulating levels of cathepsin D in preeclamptic and normotensive pregnancies. Fifty pregnant and 20 healthy non-pregnant patients were enrolled in this study...
  53. Protopapas A, Markaki S, Mitsis T, Milingos D, Athanasiou S, Haidopoulos D, et al. Immunohistochemical expression of matrix metalloproteinases, their tissue inhibitors, and cathepsin-D in ovarian endometriosis: correlation with severity of disease. Fertil Steril. 2010;94:2470-2 pubmed publisher
  54. Schechter I, Ziv E. Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s). Biol Chem. 2008;389:313-20 pubmed publisher
    ..Considering these issues, we searched for other beta-secretase candidate(s), identified cathepsin D, and evaluated properties of cathepsin D related to BACE 1 that were not examined previously...
  55. Carcel Trullols J, Kovács A, Pearce D. Role of the Lysosomal Membrane Protein, CLN3, in the Regulation of Cathepsin D Activity. J Cell Biochem. 2017;118:3883-3890 pubmed publisher
    ..In the present study, we analyzed the consequences of hyperosmolarity, and increased CLN3 expression on cathepsin D (CTSD) activity and prosaposin processing using BHK cells transiently or stably expressing myc-CLN3...
  56. Leto G, Tumminello F, Crescimanno M, Flandina C, Gebbia N. Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications. Clin Exp Metastasis. 2004;21:91-106 pubmed
    b>Cathepsin D is a lysosomal acid proteinase which is involved in the malignant progression of breast cancer and other gynecological tumors...
  57. Diep C, Ahrendt H, Lange C. Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes. Steroids. 2016;114:48-58 pubmed publisher
    ..e. estrogen) ablation and suggest caution following prolonged treatment with aromatase or CYP17 inhibitors (i.e. contexts when progesterone levels may be abnormally elevated). ..
  58. Horlock C, Shakib F, Jones N, Sewell H, Ghaemmaghami A. Differential protein expression by dendritic cells from atopic and non-atopic individuals after stimulation by the major house dust mite allergen Der p 1. Int Arch Allergy Immunol. 2009;150:237-51 pubmed publisher
    ..cell differentiation and the allergic response, including GTP-binding regulatory protein Gi alpha-2, frabin and cathepsin D. Whilst there are inherent differences between DCs from atopic and non-atopic individuals, it seems that ..
  59. Devosse T, Dutoit R, Migeotte I, de Nadai P, Imbault V, Communi D, et al. Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3. J Immunol. 2011;187:1475-85 pubmed publisher
    ..b>Cathepsin D was characterized as the protease responsible for HEBP1 processing, and the bioactive product was identified as ..
  60. Gotz W, Quondamatteo F, Ragotzki S, Affeldt J, Jager A. Localization of cathepsin D in human odontoclasts. a light and electron microscopical immunocytochemical study. Connect Tissue Res. 2000;41:185-94 pubmed
    ..Whether cathepsin D, which in osteoclasts probably functions as an activator of other cathepsins, can be found in odontoclasts, has,..
  61. Iacobuzio Donahue C, Shuja S, Cai J, Peng P, Willett J, Murnane M. Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function. Int J Oncol. 2004;24:473-85 pubmed
    b>Cathepsin D protein patterns were analyzed in 59 colorectal tumors by Western blotting, glycosylation and immunohistochemical assays...
  62. Mimae T, Tsuta K, Maeshima A, Okada M, Asamura H, Kondo T, et al. Cathepsin D as a potential prognostic marker for lung adenocarcinoma. Pathol Res Pract. 2012;208:534-40 pubmed publisher
    We previously identified cathepsin D as a possible marker for lung adenocarcinoma (AD). The purpose of the present study is to evaluate the correlation between cathepsin D expression and clinicopathological findings or prognosis...
  63. Chen D, Gao Y, Nicholas J. Human herpesvirus 8 interleukin-6 contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin K epoxide reductase complex subunit 1 variant 2. J Virol. 2014;88:1025-38 pubmed publisher
    ..Here, we report that the ER-transiting and functionally mitogenic secreted proenzyme (pCatD) form of cathepsin D (mature CatD), a proapoptotic lysosomal aspartate protease, is an interaction partner of VKORC1v2 and that vIL-..
  64. Guszcz T, Święczkowska M, Milewska E, Gorodkiewicz E, Kozłowski R, Roszkowska Jakimiec W. [Cathepsin D and B activity in the serum of patients with urothelial bladder cancer]. Pol Merkur Lekarski. 2014;36:386-8 pubmed
    The key role of cathepsin D and B is intralysosomal digestion of used cellular proteins and other proteins that enter cells through endocytosis...
  65. Lemansky P, Gieselmann V, Hasilik A, Von Figura K. Cathepsin D and beta-hexosaminidase synthesized in the presence of 1-deoxynojirimycin accumulate in the endoplasmic reticulum. J Biol Chem. 1984;259:10129-35 pubmed
    Biosynthesis, transport, and maturation of cathepsin D and beta-hexosaminidase was examined in fibroblasts exposed to 1-deoxynojirimycin, a glucose analogue known to inhibit trimming glucosidases (Saunier, B., Kilker, R. D., Jr...
  66. Cataldo A, Paskevich P, Kominami E, Nixon R. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. Proc Natl Acad Sci U S A. 1991;88:10998-1002 pubmed
    ..The actions of membrane-degrading acid hydrolases could also explain how the intramembrane portion of APP containing the C terminus of beta-amyloid becomes accessible to proteases. ..
  67. Christensen B, Schack L, Kläning E, Sørensen E. Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D. J Biol Chem. 2010;285:7929-37 pubmed publisher
    ..Another endogenous milk protease, cathepsin D, cleaved the Leu(151)-Arg(152) bond...