cathepsin B

Summary

Gene Symbol: cathepsin B
Description: cathepsin B
Alias: APPS, CPSB, cathepsin B, APP secretase, amyloid precursor protein secretase, cathepsin B1, cysteine protease
Species: human
Products:     cathepsin B

Top Publications

  1. Berquin I, Cao L, Fong D, Sloane B. Identification of two new exons and multiple transcription start points in the 5'-untranslated region of the human cathepsin-B-encoding gene. Gene. 1995;159:143-9 pubmed
    Transcripts for cysteine protease cathepsin B (CTSB) were found to be highly variable in the 5'-UTR (untranslated region)...
  2. Mehtani S, Gong Q, Panella J, Subbiah S, Peffley D, Frankfater A. In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells. J Biol Chem. 1998;273:13236-44 pubmed
    Cathepsin B is a lysosomal cysteine protease whose increased expression is believed to be linked to the malignant progression of tumors...
  3. Mai J, Finley R, Waisman D, Sloane B. Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells. J Biol Chem. 2000;275:12806-12 pubmed
    To study potential roles of plasma membrane-associated extracellular cathepsin B in tumor cell invasion and metastasis, we used the yeast two-hybrid system to screen for proteins that interact with human procathepsin B...
  4. Michallet M, Saltel F, Preville X, Flacher M, Revillard J, Genestier L. Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion. Blood. 2003;102:3719-26 pubmed
    ..The cysteine protease inhibitor E64d and cathepsin-B-specific inhibitors conferred significant protection, whereas apoptosis was ..
  5. Li J, Pober J. The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury. J Immunol. 2005;175:1858-66 pubmed
    ..that TNF in combination with LY294002, a PI3K inhibitor, activates caspase-independent cell death initiated by cathepsin B (Cat B) in HUVEC...
  6. Mahurkar S, Idris M, Reddy D, Bhaskar S, Rao G, Thomas V, et al. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. Gut. 2006;55:1270-5 pubmed
    ..As cathepsin B (CTSB) is known to activate cationic trypsinogen, we attempted to understand the role of CTSB mutations in TCP...
  7. Czyzewska J, Guzinska Ustymowicz K, Kemona A, Bandurski R. The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival. Folia Histochem Cytobiol. 2008;46:57-64 pubmed publisher
    ..The purpose of this study was to investigate the relationship of the expression of MMP-9 and cathepsin B with tumor aggressiveness expressed by lymph node metastases and survival rates in gastric carcinoma patients...
  8. Spiess E, Bruning A, Gack S, Ulbricht B, Spring H, Trefz G, et al. Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level. J Histochem Cytochem. 1994;42:917-29 pubmed
    We investigated the appearance and activity of the cysteine proteinase cathepsin B and its physiological inhibitors, stefins A and B, at the cellular level in human tumor cell lines HS-24, derived from a primary lung tumor (squamous cell)..
  9. Riccio M, Di Giaimo R, Pianetti S, Palmieri P, Melli M, Santi S. Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1). Exp Cell Res. 2001;262:84-94 pubmed
    ..Confocal microscopy analysis of the subcellular localization of cystatin B and cathepsin B shows that, in vivo, the two proteins are concentrated in different cell compartments...

More Information

Publications110 found, 100 shown here

  1. Gobeil S, Boucher C, Nadeau D, Poirier G. Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases. Cell Death Differ. 2001;8:588-94 pubmed
    ..These findings suggest that the necrotic cleavage of PARP-1 is caused in part or in totality by lysosomal proteases released during necrosis. ..
  2. Foghsgaard L, Lademann U, Wissing D, Poulsen B, Jaattela M. Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells. J Biol Chem. 2002;277:39499-506 pubmed
    ..Here, we show that cathepsin B-like proteases are required for the TNF-induced AA release in transformed cells...
  3. Yan S, Sloane B. Molecular regulation of human cathepsin B: implication in pathologies. Biol Chem. 2003;384:845-54 pubmed
    Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells...
  4. Nishikawa H, Ozaki Y, Nakanishi T, Blomgren K, Tada T, Arakawa A, et al. The role of cathepsin B and cystatin C in the mechanisms of invasion by ovarian cancer. Gynecol Oncol. 2004;92:881-6 pubmed
    The aim of this study was to investigate the contribution of cathepsin B and cystatin C to the mechanisms of invasion by ovarian cancer...
  5. Kaznelson D, Bruun S, Monrad A, Gjerløv S, Birk J, Röpke C, et al. Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation. Virology. 2004;320:301-12 pubmed
    ..E7/p21-induced cell death is associated with the activation of a newly identified mediator of apoptosis, namely cathepsin B. Activation of the cellular caspases is undetectable in cells undergoing E7/p21-induced apoptosis...
  6. Lakka S, Gondi C, Yanamandra N, Olivero W, Dinh D, Gujrati M, et al. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene. 2004;23:4681-9 pubmed
    ..Matrix metalloproteases (MMP)-9 and cathepsin B have been shown to participate in the processes of tumor growth, vascularization and invasion of gliomas...
  7. Müntener K, Zwicky R, Csucs G, Rohrer J, Baici A. Exon skipping of cathepsin B: mitochondrial targeting of a lysosomal peptidase provokes cell death. J Biol Chem. 2004;279:41012-7 pubmed
    The alternatively spliced messenger RNA of the human cysteine peptidase cathepsin B missing exons 2 and 3 encodes a truncated form of the enzyme lacking the signal peptide and part of the inhibitory propeptide...
  8. Chandran K, Sullivan N, Felbor U, Whelan S, Cunningham J. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science. 2005;308:1643-5 pubmed publisher
    ..Using selective protease inhibitors and protease-deficient cell lines, we identified an essential role for cathepsin B (CatB) and an accessory role for cathepsin L (CatL) in EboV GP-dependent entry...
  9. Premzl A, Turk V, Kos J. Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro. J Cell Biochem. 2006;97:1230-40 pubmed
    The lysosomal cysteine protease cathepsin B is implicated in degradation of extracellular matrix (ECM), a crucial step in a variety of physiological and pathological processes, including tumor dissemination and angiogenesis...
  10. Li J, D Alessio A, Pober J. Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells. Am J Pathol. 2009;175:1124-35 pubmed publisher
    ..use of proteinase inhibitors, cell death changes from being principally caspase-dependent to being principally cathepsin B (Cat B)-dependent...
  11. Andl C, McCowan K, Allison G, Rustgi A. Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner. Neoplasia. 2010;12:485-98 pubmed
    ..We also find that cathepsin B induction is necessary for fibroblast-mediated invasion...
  12. Gopinath S, Malla R, Gondi C, Alapati K, Fassett D, Klopfenstein J, et al. Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation. PLoS ONE. 2010;5:e11668 pubmed publisher
    b>Cathepsin B and urokinase plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas...
  13. Moin K, Day N, Sameni M, Hasnain S, Hirama T, Sloane B. Human tumour cathepsin B. Comparison with normal liver cathepsin B. Biochem J. 1992;285 ( Pt 2):427-34 pubmed
    b>Cathepsin B was purified from normal human liver and several human tumour tissues and partially characterized...
  14. Tsai H, Wang P, Tee Y, Lin L, Hsieh Y, Yang S. Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease. Fertil Steril. 2009;91:549-55 pubmed publisher
    To detect the serum expression of cathepsin B and cystatin C and the ratio of cathepsin B to cystatin C in patients with pelvic inflammatory disease (PID) and speculate whether those are helpful indicators for the diagnosis of PID...
  15. Hwang J, Lee S, Lee K, Lee K, Kim H, Ryu J, et al. Cathepsin B is a target of Hedgehog signaling in pancreatic cancer. Cancer Lett. 2009;273:266-72 pubmed publisher
    This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer...
  16. Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi M, Ferrari V, et al. Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. Autophagy. 2019;15:631-651 pubmed publisher
    ..athanogene 3; BECN1: beclin 1, autophagy related; CASA: chaperone-assisted selective autophagy; CTSB: cathepsin b; DAPI: 4',6-diamidino-2-phenylindole; DMEM: Dulbecco's modified Eagle's medium; EGFP: enhanced green ..
  17. Liu Y, Xue X, Zhang H, Che X, Luo J, Wang P, et al. Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. Autophagy. 2019;15:493-509 pubmed publisher
    ..virus; AIF1/IBA1, allograft inflammatory factor 1; ALP, autophagy-lysosomal pathway; CQ, chloroquine; CTSB, cathepsin B; CTSD, cathepsin D; CsA, cyclosporin A; GFAP, glial fibrillary acidic protein; LAMP, lysosomal-associated ..
  18. Ortega Pierres G, Argüello García R, Laredo Cisneros M, Fonseca Liñán R, Gómez Mondragón M, Inzunza Arroyo R, et al. Giardipain-1, a protease secreted by Giardia duodenalis trophozoites, causes junctional, barrier and apoptotic damage in epithelial cell monolayers. Int J Parasitol. 2018;48:621-639 pubmed publisher
    ..activity since almost no damage was observed when IEC-6 monolayers were incubated with papain, a non-related cysteine protease. Hence this study suggests that giardipain-1 triggers, in epithelial cells, degradation of cell-cell ..
  19. Sendler M, Weiss F, Golchert J, Homuth G, van den Brandt C, Mahajan U, et al. Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice. Gastroenterology. 2018;154:704-718.e10 pubmed publisher
    ..Pancreatitis was induced in C57Bl/6 wild-type (control), cathepsin B (CTSB)-knockout, and cathepsin L-knockout mice by partial pancreatic duct ligation with supramaximal caerulein ..
  20. Lowry J, Klegeris A. Emerging roles of microglial cathepsins in neurodegenerative disease. Brain Res Bull. 2018;139:144-156 pubmed publisher
    ..inhibition of microglial cathepsin B may lead to neuroprotective outcomes in AD, while the functions of this cysteine protease in neurons appears to be very complex and further studies are required to fully elucidate the ..
  21. Aghdassi A, John D, Sendler M, Weiss F, Reinheckel T, Mayerle J, et al. Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis. J Biol Chem. 2018;293:1018-1029 pubmed publisher
    ..An initiating event is the intracellular activation of trypsinogen by cathepsin B (CTSB), which can be induced directly via G protein-coupled receptors on acinar cells or through inflammatory ..
  22. Schröder J, Noack S, Marhofer R, Mottram J, Coombs G, Selzer P. Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB. PLoS ONE. 2013;8:e77460 pubmed publisher
    ..Homology modeling of the mature Leishmania mexicana cysteine protease CPB2.8 suggested that it differs significantly from bovine cathepsin B and thus could be a good drug target...
  23. Erban T, Rybanska D, Harant K, Hortova B, Hubert J. Feces Derived Allergens of Tyrophagus putrescentiae Reared on Dried Dog Food and Evidence of the Strong Nutritional Interaction between the Mite and Bacillus cereus Producing Protease Bacillolysins and Exo-chitinases. Front Physiol. 2016;7:53 pubmed publisher
    ..was assigned to trypsin-like proteases; lower activity was assigned to chymotrypsin-like proteases, and the cysteine protease cathepsin B-like had very low activity...
  24. Feng X, Li F, Wang F, Zhang G, Pang J, Ren C, et al. Genome-wide differential expression profiling of mRNAs and lncRNAs associated with prolificacy in Hu sheep. Biosci Rep. 2018;38: pubmed publisher
    ..We constructed a co-expression network of DE-mRNAs and mRNA-lncRNAs, with C1qA, CD53, cathepsin B (CTSB), CTSS, TYROBP, and AIF1 as the hub genes...
  25. Xiao Y, Yuan W, Yu B, Guo Y, Xu X, Wang X, et al. Targeted Gene Next-Generation Sequencing in Chinese Children with Chronic Pancreatitis and Acute Recurrent Pancreatitis. J Pediatr. 2017;191:158-163.e3 pubmed publisher
    ..transmembrane conductance regulator gene (CFTR), chymotrypsin C (CTRC), calcium-sensing receptor (CASR), cathepsin B (CTSB), keratin 8 (KRT8), CLAUDIN 2 (CLDN2), carboxypeptidase A1 (CPA1), and ATPase type 8B member 1 (ATP8B1)...
  26. Kędzior M, Pawlak A, Seredyński R, Bania J, Platt Samoraj A, Czemplik M, et al. Revealing the inhibitory potential of Yersinia enterocolitica on cysteine proteases of the papain family. Microbiol Res. 2018;207:211-225 pubmed publisher
    ..Nevertheless, the bacterium has not yet been shown to produce any cysteine protease inhibitors. Here we demonstrate that Y...
  27. Sandes E, Lodillinsky C, Cwirenbaum R, Argüelles C, Casabé A, Eiján A. Cathepsin B is involved in the apoptosis intrinsic pathway induced by Bacillus Calmette-Guérin in transitional cancer cell lines. Int J Mol Med. 2007;20:823-8 pubmed
    ..Thus, apoptosis of bladder cancer cells could contribute to a global response to BCG. Lysosomal hydrolase cathepsin B (CB) is involved in the apoptotic process and has a key role in breast cancer cell programmed death through the ..
  28. Wyczałkowska Tomasik A, Paczek L. Cathepsin B and L activity in the serum during the human aging process: cathepsin B and L in aging. Arch Gerontol Geriatr. 2012;55:735-8 pubmed publisher
    b>Cathepsin B and L are active in several physiological processes that occur in the human body...
  29. Ben Zeev D. Mobile Health for All: Public-Private Partnerships Can Create a New Mental Health Landscape. JMIR Ment Health. 2016;3:e26 pubmed publisher
    ..through subsidy programs, will have "smart" capabilities (ie, internet connectivity and the capacity to host apps)...
  30. Mugita N, Nambu T, Takahashi K, Wang P, Komasa Y. Proteases, actinidin, papain and trypsin reduce oral biofilm on the tongue in elderly subjects and in vitro. Arch Oral Biol. 2017;82:233-240 pubmed publisher
    ..The in vivo effect of actinidin, a cysteine protease, on the removal of tongue coating was assessed after orally taking a protease tablet...
  31. Dinler C, Ulutas B, Voyvoda H, Ulutas P, Ural K, Karagenc T. Haptoglobin and serum amyloid-A concentrations and their relationship with oocyst count in neonatal lambs experimentally infected with Cryptosporidium parvum. Vet Parasitol. 2017;247:49-56 pubmed publisher
    ..serum amyloid A (SAA) concentrations in serum and to examine the correlation between these acute phase proteins (APPs) and oocyst shedding using experimental Cryptosporidium parvum (C. parvum) infection model in neonatal lambs...
  32. Anu P, Madanan M, Nair A, Nair G, Nair G, Sudhakaran P, et al. Heterologous Expression, Purification and Characterization of an Oligopeptidase A from the Pathogen Leptospira interrogans. Mol Biotechnol. 2018;60:302-309 pubmed publisher
    ..more than 80% inhibition with a serine protease inhibitor but the activity was reduced to 30% with the cysteine protease inhibitor...
  33. Daroszewski J, Bolanowski M, Kaluzny M, Siewinski M. The imbalance of cathepsin B-like activity in acromegalic patients--preliminary report. Neuro Endocrinol Lett. 2010;31:256-60 pubmed
    ..Cysteine proteases (CP), including cathepsin B, have been tested in a number of pathologies in respect of a role in pathogenesis and potential utility in the ..
  34. Hirshfield S, Grov C, Parsons J, Anderson I, Chiasson M. Social media use and HIV transmission risk behavior among ethnically diverse HIV-positive gay men: results of an online study in three U.S. states. Arch Sex Behav. 2015;44:1969-78 pubmed publisher
    ..Median age was 46 (range 18-79). Men who reported using 3 or more websites or apps to meet sex partners were significantly more likely to report anal intercourse (AOR 4.43, p < ...
  35. Ubhi H, Kotz D, Michie S, van Schayck O, Sheard D, Selladurai A, et al. Comparative analysis of smoking cessation smartphone applications available in 2012 versus 2014. Addict Behav. 2016;58:175-81 pubmed publisher
    Smartphone applications (apps) offer a potentially cost-effective and a wide-reach aid to smoking cessation...
  36. Finkelstein J, Cha E. Using a Mobile App to Promote Smoking Cessation in Hospitalized Patients. JMIR Mhealth Uhealth. 2016;4:e59 pubmed publisher
    ..However, use of mobile apps to promote smoking cessation in hospitalized patients has not been systematically assessed...
  37. Wellde P, Miller L. There's an App for That!: New Directions Using Social Media in Patient Education and Support. J Perinat Neonatal Nurs. 2016;30:198-203 pubmed publisher
    ..b>Apps and Web sites from professional organizations as well as private individuals and commercial businesses abound...
  38. Alnasser A, Amalraj R, Sathiaseelan A, Al Khalifa A, Marais D. Do Arabic weight-loss apps adhere to evidence-informed practices?. Transl Behav Med. 2016;6:396-402 pubmed publisher
    ..This study aimed to identify whether current Arabic weight-loss apps had features that adhered to evidence-informed practices...
  39. Thapa A, Kc B, Shakya B. Cost Effective Use of Free-to-Use Apps in Neurosurgery (FAN) in Developing Countries: From Clinical Decision Making to Educational Courses, Strengthening Health Care Delivery. World Neurosurg. 2016;95:270-275 pubmed publisher
    ..Out of necessity we used free-to-use apps in our practice...
  40. Eikey E, Reddy M, Booth K, Kvasny L, Blair J, Li V, et al. Desire to Be Underweight: Exploratory Study on a Weight Loss App Community and User Perceptions of the Impact on Disordered Eating Behaviors. JMIR Mhealth Uhealth. 2017;5:e150 pubmed publisher
    Mobile health (mHealth) apps for weight loss (weight loss apps) can be useful diet and exercise tools for individuals in need of losing weight...
  41. Short C, Finlay A, Sanders I, Maher C. Development and pilot evaluation of a clinic-based mHealth app referral service to support adult cancer survivors increase their participation in physical activity using publicly available mobile apps. BMC Health Serv Res. 2018;18:27 pubmed publisher
    ..A systematic search identified potentially appropriate Apple (iOS) and Android mHealth apps. The apps were audited regarding the type of physical activity encouraged, evidence-based behavioural strategies ..
  42. Caglic D, Kosec G, Bojic L, Reinheckel T, Turk V, Turk B. Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery. Biol Chem. 2009;390:175-9 pubmed publisher
    ..It is important, therefore, to know whether similar differences exist between murine and human cathepsin B. Thus, both enzymes were expressed and biochemically characterized...
  43. Alli A, Song J, Al Khalili O, Bao H, Ma H, Alli A, et al. Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity. J Biol Chem. 2012;287:30073-83 pubmed publisher
    ..Here, we report that Xenopus 2F3 cells apically express the cysteine protease cathepsin B, as indicated by two-dimensional gel electrophoresis and mass spectrometry analysis...
  44. Christensen S, Huffaker A, Hunter C, Alborn H, Schmelz E. A maize death acid, 10-oxo-11-phytoenoic acid, is the predominant cyclopentenone signal present during multiple stress and developmental conditions. Plant Signal Behav. 2016;11:e1120395 pubmed publisher
    ..As a potent cell death signal, 10-OPEA activates cysteine protease activity leading to ion leakage and apoptotic-like DNA fragmentation...
  45. Dunton G, Dzubur E, INTILLE S. Feasibility and Performance Test of a Real-Time Sensor-Informed Context-Sensitive Ecological Momentary Assessment to Capture Physical Activity. J Med Internet Res. 2016;18:e106 pubmed publisher
    ..91, 95% confidence interval=2.16-11.12). Mobile phone apps using motion sensor-informed CS-EMA are acceptable among high school students and may be used to augment objective ..
  46. Milani R, Franklin N. The Role of Technology in Healthy Living Medicine. Prog Cardiovasc Dis. 2017;59:487-491 pubmed publisher
    ..Approximately 77% of Americans now own a smartphone and the use of health apps have doubled over the past two years...
  47. Wangkahart E, Secombes C, Wang T. Dissecting the immune pathways stimulated following injection vaccination of rainbow trout (Oncorhynchus mykiss) against enteric redmouth disease (ERM). Fish Shellfish Immunol. 2019;85:18-30 pubmed publisher
    ..analysed the expression in spleen and gills of a large set of genes encoding for cytokines, acute phase proteins (APPs) and antimicrobial peptides (AMPs) in response to ERM vaccination in rainbow trout, Oncorhynchus mykiss...
  48. Hilty D, Turvey C, Hwang T. Lifelong Learning for Clinical Practice: How to Leverage Technology for Telebehavioral Health Care and Digital Continuing Medical Education. Curr Psychiatry Rep. 2018;20:15 pubmed publisher
    ..g., social media/networking, text, apps)...
  49. Yi M, Kim H, Jeong K, Kim C, Kim T, Yong T. House dust mite allergen Der f 1 induces IL-8 in human basophilic cells via ROS-ERK and p38 signal pathways. Cytokine. 2015;75:356-64 pubmed publisher
    Der f 1, a major house dust mite allergen and member of the papain-like cysteine protease family, can provoke immune responses with its proteolytic activity...
  50. Gilliland J, Donnellan A, Justice L, Moake L, Mauney J, Steadman P, et al. Establishment of Pediatric Cardiac Intensive Care Advanced Practice Provider Services. World J Pediatr Congenit Heart Surg. 2016;7:72-80 pubmed publisher
    The addition of advanced practice providers (APPs; nurse practitioners and physician assistants) to a pediatric cardiac intensive care unit (PCICU) team is a health care innovation that addresses medical provider shortages while allowing ..
  51. Pai Y, Chen Y, Hung C, Liu H, Lai Y, Ko N. [Willingness to Receive Text Message Appointment Reminders Among Patients With HIV Infection]. Hu Li Za Zhi. 2016;63:59-67 pubmed publisher
    ..The rapid expansion of mobile technologies, including smartphone applications (apps), provides a unique opportunity to effectively remind patients about regular follow-up appointments, thereby ..
  52. Giosan C, Cobeanu O, Mogoase C, Szentagotai A, Muresan V, Boian R. Reducing depressive symptomatology with a smartphone app: study protocol for a randomized, placebo-controlled trial. Trials. 2017;18:215 pubmed publisher
    ..g., smartphones) in the form of "apps." Preliminary research on some depression apps has shown promising results in reducing subthreshold or mild to ..
  53. Zhang T, Yang Z, Bo X, Wu X, Li Z, Guo S. [Cathepsin B promoted the apoptosis of vascular smooth muscle cells as induced by tumor necrosis factor-?]. Zhonghua Yi Xue Za Zhi. 2011;91:845-9 pubmed
    To establish the cathepsin B over-expression group and cathepsin B gene-silencing group so as to investigate whether cathepsin B was capable of promoting the apoptosis of VSMC (vascular smooth muscle cell) induced by TNF-?/act D...
  54. Curtis K, Lahiri S, Brown K. Targeting Parents for Childhood Weight Management: Development of a Theory-Driven and User-Centered Healthy Eating App. JMIR Mhealth Uhealth. 2015;3:e69 pubmed publisher
    The proliferation of health promotion apps along with mobile phones' array of features supporting health behavior change offers a new and innovative approach to childhood weight management...
  55. Saidi S, Nabian S, Ebrahimzade E, Najafi A, Moghaddam M, Sazmand A, et al. Identification and characterization of a cathepsin L-like cysteine protease from Rhipicephalus (Boophilus) annulatus. Exp Appl Acarol. 2016;68:251-65 pubmed publisher
    ..Based on bioinformatics analyses, results of this work suggest that RaCL1 can be a suitable candidate for the development of vaccine against R. annulatus. ..
  56. Castensøe Seidenfaden P, Reventlov Husted G, Teilmann G, Hommel E, Olsen B, Kensing F. Designing a Self-Management App for Young People With Type 1 Diabetes: Methodological Challenges, Experiences, and Recommendations. JMIR Mhealth Uhealth. 2017;5:e124 pubmed publisher
    Young people with type 1 diabetes often struggle to self-manage their disease. Mobile health (mHealth) apps show promise in supporting self-management of chronic conditions such as type 1 diabetes...
  57. O Connor S. Big Data and Data Science in Healthcare: What Nurses and Midwives Need to Know. J Clin Nurs. 2017;: pubmed publisher
    ..From monitoring nutrition via mobile apps, to tracking exercise and physiological signs on wearable devices, and sharing personal information on family, ..
  58. Vu M, Nguyen V, Vishwanath S, Wolfe C, Patel S. Know Your Numbers: Creation and implementation of a novel community health mobile application (app) by student pharmacists. J Am Pharm Assoc (2003). 2017;: pubmed publisher
    ..The study objectives included creating a health app, implementing a pilot program, and analyzing the frequency of app use and perceptions of community members toward their health numbers, pharmacists, and health apps.
  59. Han H, Zhou H, Sun W, Liu C, Hou X, Zhou W. [Knockdown of TRAIL-DR5 gene inhibits autophagy of ER-positive MCF-7 breast cancer cells induced by SAHA]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017;33:1504-1510 pubmed
    ..The expressions of beclin-1, ATG3, ATG5, ATG7, ATG12, ATG16, ATG4A, ATG4B, ATG9B, LC3II, cathepsin B (CTSB) in the breast cancer cells were detected by Western blotting...
  60. Ekins S, Clark A, Wright S. Making Transporter Models for Drug-Drug Interaction Prediction Mobile. Drug Metab Dispos. 2015;43:1642-5 pubmed publisher
    ..One way to surmount this is to make models shareable or more accessible. The development of mobile apps that can access such models is highlighted here...
  61. Price M, Sawyer T, Harris M, Skalka C. Usability Evaluation of a Mobile Monitoring System to Assess Symptoms After a Traumatic Injury: A Mixed-Methods Study. JMIR Ment Health. 2016;3:e3 pubmed publisher
    ..The multiple demands of the acute post-trauma period present numerous barriers to such assessments. Mobile apps are a method by which to overcome these barriers in order to regularly assess symptoms, identify those at risk, and ..
  62. Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh M, McGovern O, et al. Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nat Microbiol. 2017;2:17096 pubmed publisher
    ..We found that disrupting a VAC-localized cysteine protease compromised VAC digestive function and markedly reduced chronic infection...
  63. Lindén M, Ramírez Sepúlveda J, James T, Thorlacius G, Brauner S, Gomez Cabrero D, et al. Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms. Biol Sex Differ. 2017;8:34 pubmed publisher
    ..We identified several unknown sex-specific eQTL effects of SLE/pSS-associated genetic polymorphisms and provide novel insight into how gene-sex interactions may contribute to the sex bias in systemic autoimmune diseases. ..
  64. Baumgrass R, Williamson M, Price P. Identification of peptide fragments generated by digestion of bovine and human osteocalcin with the lysosomal proteinases cathepsin B, D, L, H, and S. J Bone Miner Res. 1997;12:447-55 pubmed
    ..Cathepsins B, L, H, and S readily cleave BGP at the G7-A8 bond; cathepsin L also cleaves at R43-R44; cathepsin B also cleaves at R44-F45; and cathepsin D cleaves only at A41-Y42...
  65. Benarafa C, Cooley J, Zeng W, Bird P, REMOLD O DONNELL E. Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1). J Biol Chem. 2002;277:42028-33 pubmed
    ..These data demonstrate that the four murine homologs of MNEI have met different evolutionary fates, and that EIA is the mouse ortholog of MNEI. ..
  66. Wagholikar K, Mandel J, Klann J, Wattanasin N, Mendis M, Chute C, et al. SMART-on-FHIR implemented over i2b2. J Am Med Inform Assoc. 2017;24:398-402 pubmed publisher
    ..The SMART-on-FHIR cell will enable i2b2 sites to provide simplified but secure data access in FHIR format, and will spur innovation and interoperability. Further, it transforms i2b2 into an apps platform.
  67. Jafari A, Qanie D, Andersen T, Zhang Y, Chen L, Postert B, et al. Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis. Stem Cell Reports. 2017;8:373-386 pubmed publisher
    ..Legumain is a secreted cysteine protease involved in diverse biological processes...
  68. Roriz P, Yanai A, Fearnside P. Deforestation and Carbon Loss in Southwest Amazonia: Impact of Brazil's Revised Forest Code. Environ Manage. 2017;60:367-382 pubmed publisher
    ..4771/1965) and the current Code (Law 12,651/2012) regarding the protection of "areas of permanent preservation" (APPs) along the edges of watercourses...
  69. Li M, Li D, Tang Y, Wu F, Wang J. CytoCluster: A Cytoscape Plugin for Cluster Analysis and Visualization of Biological Networks. Int J Mol Sci. 2017;18: pubmed publisher
    ..CytoCluster is available from http://apps.cytoscape.org/apps/cytocluster.
  70. Xu W, Flores Mireles A, Cusumano Z, Takagi E, Hultgren S, Caparon M. Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection. NPJ Biofilms Microbiomes. 2017;3:28 pubmed publisher
    ..significantly inhibited dissemination from bladder to kidney and revealed an essential role for a host cysteine protease in promoting pathogenesis...
  71. Beckham T, Lu P, Cheng J, Zhao D, Turner L, Zhang X, et al. Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012;131:2034-43 pubmed publisher
    ..S1P), promotes Ets1 nuclear expression and binding to the promoter region of matrix-degrading protease cathepsin B. Through confocal microscopy and flow cytometry, we found that AC overexpression promotes pericellular ..
  72. Sage J, Leblanc Noblesse E, Nizard C, Sasaki T, Schnebert S, Perrier E, et al. Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners. PLoS ONE. 2012;7:e43494 pubmed publisher
  73. Mullins S, Sameni M, Blum G, Bogyo M, Sloane B, Moin K. Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins. Biol Chem. 2012;393:1405-16 pubmed
    The expression of the cysteine protease cathepsin B is increased in early stages of human breast cancer...
  74. Bengsch F, Buck A, Günther S, Seiz J, Tacke M, Pfeifer D, et al. Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression. Oncogene. 2014;33:4474-84 pubmed publisher
    The cysteine protease cathepsin B (CTSB) is frequently overexpressed in human breast cancer and correlated with a poor prognosis...
  75. Kayyali R, Peletidi A, Ismail M, Hashim Z, Bandeira P, Bonnah J. Awareness and Use of mHealth Apps: A Study from England. Pharmacy (Basel). 2017;5: pubmed publisher
    ..This study was conducted in England. It aimed to determine the use and recommendation of mHealth apps by pharmacists, the public's perceptions of mHealth apps in general, and the awareness and use of health apps by ..
  76. Jutras I, Reudelhuber T. Prorenin processing by cathepsin B in vitro and in transfected cells. FEBS Lett. 1999;443:48-52 pubmed
    ..The lysosomal hydrolase cathepsin B has been proposed as a prorenin processing enzyme based on reports of its co-localization with renin in the ..
  77. Quraishi O, Storer A. Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain f. J Biol Chem. 2001;276:8118-24 pubmed
  78. Fernandez P, Farre X, Nadal A, Fernandez E, Peiró N, Sloane B, et al. Expression of cathepsins B and S in the progression of prostate carcinoma. Int J Cancer. 2001;95:51-5 pubmed
  79. Wu S, Rhee K, Zhang M, Franco A, Sears C. Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage. J Cell Sci. 2007;120:1944-52 pubmed
    ..Our results suggest that differentially regulated beta-catenin pools associate with the E-cadherin-gamma-secretase adherens junction complex; one pool regulated by gamma-secretase is important to intestinal epithelial cell homeostasis. ..
  80. Lamore S, Wondrak G. UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts. J Photochem Photobiol B. 2013;123:1-12 pubmed publisher
    ..Recently, we have identified the thiol-dependent cysteine-protease cathepsin B as a novel UVA-target undergoing photo-oxidative inactivation upstream of autophagic-lysosomal dysfunction in ..
  81. Kow A, Ang B, Chong C, Tan W, Menon K. Innovative Patient Safety Curriculum Using iPAD Game (PASSED) Improved Patient Safety Concepts in Undergraduate Medical Students. World J Surg. 2016;40:2571-2580 pubmed
    ..A new innovation using mobile apps gaming system (PAtient Safety in Surgical EDucation-PASSED) to teach medical students on patient safety was created...
  82. Peng Y, Zhang M, Zheng L, Liang Q, Li H, Chen J, et al. Cysteine protease cathepsin B mediates radiation-induced bystander effects. Nature. 2017;547:458-462 pubmed publisher
    ..Here we use Caenorhabditis elegans as a model in which to study RIBEs, and identify the cysteine protease CPR-4, a homologue of human cathepsin B, as the first RIBE factor in nematodes, to our knowledge...
  83. Liang J, Li J, Han Y, Luo Y, Xue Y, Zhang Y, et al. Calpain-GRIP Signaling in Nucleus Accumbens Core Mediates the Reconsolidation of Drug Reward Memory. J Neurosci. 2017;37:8938-8951 pubmed publisher
    ..Calpain, a calcium-dependent neutral cysteine protease, is involved in synaptic plasticity and the formation of long-term fear memory...
  84. Han H, Zhou H, Li J, Feng X, Zou D, Zhou W. TRAIL DR5-CTSB crosstalk participates in breast cancer autophagy initiated by SAHA. Cell Death Discov. 2017;3:17052 pubmed publisher
    ..These results provide more evidence that SAHA may stimulate TRAIL DR5-CTSB crosstalk, influence the activity of downstream TOR signalling pathway mainly through the AKTs pathway, and initiate the autophagy of breast cancer cells...
  85. Kotecha D, Chua W, Fabritz L, Hendriks J, Casadei B, Schotten U, et al. European Society of Cardiology smartphone and tablet applications for patients with atrial fibrillation and their health care providers. Europace. 2017;: pubmed publisher
    ..in collaboration with the European Society of Cardiology (ESC), has funded the creation of two applications (apps) in atrial fibrillation (AF) for use in smartphones and tablets...
  86. Zhao Y, Han M, Xiong Y, Wang L, Fei Y, Shen X, et al. A miRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial-mesenchymal transition. Acta Pharmacol Sin. 2018;39:1034-1047 pubmed publisher
    Cathepsin L (CTSL), a cysteine protease, is closely related to tumor occurrence, development, and metastasis, and possibly regulates cancer cell resistance to chemotherapy...
  87. Warfel A, Cardozo C, Yoo O, Zucker Franklin D. Cystatin C and cathepsin B production by alveolar macrophages from smokers and nonsmokers. J Leukoc Biol. 1991;49:41-7 pubmed
    The capacity of alveolar macrophages (AM) obtained from smokers and nonsmokers to secrete cathepsin B and its inhibitor cystatin C was examined because of the concept that an imbalance in the production of proteolytic enzymes and/or ..
  88. McKay M, Offermann M, Barrett A, Bond J. Action of human liver cathepsin B on the oxidized insulin B chain. Biochem J. 1983;213:467-71 pubmed
    The lysosomal cysteine proteinase cathepsin B (from human liver) was tested for its peptide-bond specificity against the oxidized B-chain of insulin...
  89. Royer Zemmour B, Ponsole Lenfant M, Gara H, Roll P, Leveque C, Massacrier A, et al. Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. Hum Mol Genet. 2008;17:3617-30 pubmed publisher
    ..component of the extracellular plasminogen proteolysis system; two more SRPX2 partners identified here, the cysteine protease cathepsin B (CTSB) and the metalloproteinase ADAMTS4, are also components of the extracellular proteolysis ..
  90. Yu N, Wang Z, Zhao H, Wu Y, Zhou P. [The expression and role of Cathepsin B in intracranial aneurysm wall]. Zhonghua Wai Ke Za Zhi. 2010;48:457-60 pubmed
    To detect the expression of Cathepsin B (CatB) in the intracranial aneurysm wall and its effect to the apoptosis of vascular smooth muscle cells, aimed at clarifying the pathological formation mechanism of intracranial aneurysm...
  91. Byrne S, Aucher A, Alyahya S, Elder M, Olson S, Davis D, et al. Cathepsin B controls the persistence of memory CD8+ T lymphocytes. J Immunol. 2012;189:1133-43 pubmed publisher
    ..Spi2A protected memory cells from lysosomal breakdown by inhibiting cathepsin B. The impaired maintenance of Spi2A-deficient memory CD8(+) T cells was rescued by concomitant cathepsin B ..
  92. Moreno M, Ball M, Rukhlova M, Slinn J, L abbe D, Iqbal U, et al. IGFBP-4 anti-angiogenic and anti-tumorigenic effects are associated with anti-cathepsin B activity. Neoplasia. 2013;15:554-67 pubmed
    ..both growth factor-induced EC tubulogenesis in Matrigel and the concomitant increases in intracellular cathepsin B (CatB) activity. In vitro assays confirmed CIBP-4 capacity to block recombinant CatB activity...