CASK

Summary

Gene Symbol: CASK
Description: calcium/calmodulin dependent serine protein kinase
Alias: CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, hCASK, peripheral plasma membrane protein CASK, calcium/calmodulin-dependent serin protein kinase, calcium/calmodulin-dependent serine protein kinase (MAGUK family), calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, protein lin-2 homolog, trinucleotide repeat containing 8
Species: human
Products:     CASK

Top Publications

  1. Wang Q, Lu J, Yang C, Wang X, Cheng L, Hu G, et al. CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma. Cancer Lett. 2002;179:71-7 pubmed
    Calcium/calmodulin-dependent serine protein kinase (CASK) showed overexpression in human esophageal carcinoma by suppression subtractive hybridization...
  2. Hsueh Y. The role of the MAGUK protein CASK in neural development and synaptic function. Curr Med Chem. 2006;13:1915-27 pubmed
    b>CASK, which belongs to the family of membrane-associated guanylate kinase (MAGUK) proteins, is recognized as a multidomain scaffolding protein highly expressed in the mammalian nervous system...
  3. Atasoy D, Schoch S, Ho A, Nadasy K, Liu X, Zhang W, et al. Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A. 2007;104:2525-30 pubmed
    b>CASK is an evolutionarily conserved multidomain protein composed of an N-terminal Ca2+/calmodulin-kinase domain, central PDZ and SH3 domains, and a C-terminal guanylate kinase domain...
  4. Ojeh N, Pekovic V, Jahoda C, Määttä A. The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J Cell Sci. 2008;121:2705-17 pubmed publisher
    The Ca2+/calmodulin-associated Ser/Thr kinase (CASK) binds syndecans and other cell-surface proteins through its PDZ domain and has been implicated in synaptic assembly, epithelial polarity and neuronal gene transcription...
  5. Stafford R, Ear J, Knight M, Bowie J. The molecular basis of the Caskin1 and Mint1 interaction with CASK. J Mol Biol. 2011;412:3-13 pubmed publisher
    Calcium/calmodulin-dependent serine protein kinase (CASK) is a conserved multi-domain scaffolding protein involved in brain development, synapse formation, and establishment of cell polarity...
  6. Daniels D, Cohen A, Anderson J, Brunger A. Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition. Nat Struct Biol. 1998;5:317-25 pubmed
    ..The first crystal structure of a class II PDZ domain, that of hCASK, has been solved by multi-wavelength anomalous dispersion phasing...
  7. Piluso G, D Amico F, Saccone V, Bismuto E, Rotundo I, Di Domenico M, et al. A missense mutation in CASK causes FG syndrome in an Italian family. Am J Hum Genet. 2009;84:162-77 pubmed publisher
    ..83G-->T) missense mutation in CASK causes FGS phenotype in an Italian family previously mapped to Xp11.4-p11.3 (FGS4)...
  8. Hsueh Y. Calcium/calmodulin-dependent serine protein kinase and mental retardation. Ann Neurol. 2009;66:438-43 pubmed publisher
    Calcium/calmodulin-dependent serine protein kinase (CASK) belongs to the membrane-associated guanylate kinase protein family...
  9. Moog U, Kutsche K, Kortüm F, Chilian B, Bierhals T, Apeshiotis N, et al. Phenotypic spectrum associated with CASK loss-of-function mutations. J Med Genet. 2011;48:741-51 pubmed publisher
    Heterozygous mutations in the CASK gene in Xp11.4 have been shown to be associated with a distinct brain malformation phenotype in females, including disproportionate pontine and cerebellar hypoplasia...

More Information

Publications115 found, 100 shown here

  1. Marquez Rosado L, Singh D, Rincón Arano H, Solan J, Lampe P. CASK (LIN2) interacts with Cx43 in wounded skin and their coexpression affects cell migration. J Cell Sci. 2012;125:695-702 pubmed publisher
    ..Co-immunoprecipitation, in vitro binding and far western experiments demonstrate that mammalian CASK (also known as LIN2) directly interacts with Cx43...
  2. Hata Y, Butz S, Sudhof T. CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. J Neurosci. 1996;16:2488-94 pubmed
    ..for intracellular molecules interacting with different neurexins, we identified a single interacting protein called CASK. CASK is composed of an N-terminal Ca2+, calmodulin-dependent protein kinase sequence and a C-terminal region that ..
  3. Cohen A, Woods D, Marfatia S, Walther Z, Chishti A, Anderson J, et al. Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J Cell Biol. 1998;142:129-38 pubmed
    ..We have cloned and characterized the human homolog of LIN-2, termed hCASK, and Northern and Western blot analyses reveal that it is ubiquitously expressed...
  4. Hsueh Y, Wang T, Yang F, Sheng M. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature. 2000;404:298-302 pubmed
    ..b>CASK/LIN-2, a MAGUK required for EGF receptor localization and signalling in Caenorhabditis elegans, contains a ..
  5. Najm J, Horn D, Wimplinger I, Golden J, Chizhikov V, Sudi J, et al. Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum. Nat Genet. 2008;40:1065-7 pubmed publisher
    b>CASK is a multi-domain scaffolding protein that interacts with the transcription factor TBR1 and regulates expression of genes involved in cortical development such as RELN...
  6. Hackett A, Tarpey P, Licata A, Cox J, Whibley A, Boyle J, et al. CASK mutations are frequent in males and cause X-linked nystagmus and variable XLMR phenotypes. Eur J Hum Genet. 2010;18:544-52 pubmed publisher
    Mutations of the calcium/calmodulin-dependent serine protein kinase (CASK) gene have recently been associated with X-linked mental retardation (XLMR) with microcephaly, optic atrophy and brainstem and cerebellar hypoplasia, as well as ..
  7. Kuo T, Hong C, Chien H, Hsueh Y. X-linked mental retardation gene CASK interacts with Bcl11A/CTIP1 and regulates axon branching and outgrowth. J Neurosci Res. 2010;88:2364-73 pubmed publisher
    Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription...
  8. Mukherjee K, Sharma M, Urlaub H, Bourenkov G, Jahn R, Sudhof T, et al. CASK Functions as a Mg2+-independent neurexin kinase. Cell. 2008;133:328-39 pubmed publisher
    b>CASK is a unique MAGUK protein that contains an N-terminal CaM-kinase domain besides the typical MAGUK domains...
  9. Hayashi S, Mizuno S, Migita O, Okuyama T, Makita Y, Hata A, et al. The CASK gene harbored in a deletion detected by array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation. Am J Med Genet A. 2008;146A:2145-51 pubmed publisher
    ..Among the other five genes, CASK seems to be the most likely candidate for a causative gene, because it is strongly expressed in fetal brain and ..
  10. Andrews R, Galileo D, Martin DeLeon P. Plasma membrane Ca2+-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+/CaM-dependent serine kinase. Mol Hum Reprod. 2015;21:832-43 pubmed publisher
    ..Further, along with Ca(2+)/CaM-dependent serine kinase (CASK), PMCA4 and the NOSs are present in the seminal plasma, specifically in prostasomes where Co-IP showed complexes ..
  11. Sundburg C, Belanger J, Bannasch D, Famula T, Oberbauer A. Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study. BMC Vet Res. 2016;12:278 pubmed
    ..the prevalence and risk of atopic dermatitis (ATOP), autoimmune hemolytic anemia (AIHA), canine myasthenia gravis (CMG), colitis (COL), hypoadrenocorticism (ADD), hypothyroidism (HYPO), immune-mediated polyarthritis (IMPA), immune-..
  12. Al Dossary A, Strehler E, Martin DeLeon P. Expression and secretion of plasma membrane Ca2+-ATPase 4a (PMCA4a) during murine estrus: association with oviductal exosomes and uptake in sperm. PLoS ONE. 2013;8:e80181 pubmed publisher
    ..We have previously shown that the PMCA4b splice variant interacts with CASK (Ca(2+/)CaM-dependent serine kinase) in regulating sperm Ca(2+)...
  13. Loviglio M, Beck C, White J, Leleu M, Harel T, Guex N, et al. Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics. Genome Med. 2016;8:105 pubmed
    ..Eight of these changes affect KMT2D, ZEB2, MAP2K2, GLDC, CASK, MECP2, KDM5C, and POGZ, known to be associated with Kabuki syndrome 1, Mowat-Wilson syndrome, cardiofaciocutaneous ..
  14. Dunn H, Ferguson S. PDZ Protein Regulation of G Protein-Coupled Receptor Trafficking and Signaling Pathways. Mol Pharmacol. 2015;88:624-39 pubmed publisher
  15. Liu Y, Sowell S, Luo Y, Chaubey A, Cameron R, Kim H, et al. Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment. PLoS ONE. 2015;10:e0123106 pubmed publisher
    ..have shown that KIRREL3 interacts with the X-linked intellectual disability associated synaptic scaffolding protein CASK through its cytoplasmic domain...
  16. Kamijo A, Saitoh Y, Ohno N, Ohno S, Terada N. Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine. Histochem Cell Biol. 2016;145:81-92 pubmed publisher
    ..In the immunoprecipitation study, another MAGUK family protein, calcium/calmodulin-dependent serine protein kinase (CASK), was shown to molecularly interact with MPP6...
  17. Ogino H, Ishino S, Kohda D, Ishino Y. The RecJ2 protein in the thermophilic archaeon Thermoplasma acidophilum is a 3'-5' exonuclease that associates with a DNA replication complex. J Biol Chem. 2017;292:7921-7931 pubmed publisher
    ..Eukaryotic Cdc45 has no identified enzymatic activity but participates in the CMG complex, so named because it is composed of Cdc45, minichromosome maintenance protein complex (MCM) proteins 2-7, ..
  18. Jiang M, Qiu J, Zhang L, Lu D, Long M, Chen L, et al. Changes in tension regulates proliferation and migration of fibroblasts by remodeling expression of ECM proteins. Exp Ther Med. 2016;12:1542-1550 pubmed
    ..Particularly, the roles of calcium/calmodulin-dependent serine protein kinase (CASK) in the HF proliferation under cyclic stretch were investigated...
  19. Kashyap M, Pore S, Chancellor M, Yoshimura N, Tyagi P. Bladder overactivity involves overexpression of MicroRNA 132 and nerve growth factor. Life Sci. 2016;167:98-104 pubmed publisher
    ..25% acetic acid at the rate of 0.04mL/min for 2h under urethane anesthesia (1g/kg; s.c). After CMG, bladder was harvested to study expression of NGF, cytokines and 8 specific miRNAs involved in bladder dysfunctions...
  20. Sonneville R, Craig G, Labib K, Gartner A, Blow J. Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos. Cell Rep. 2015;12:405-17 pubmed publisher
    ..Upon replication initiation, the CDC-45-MCM-GINS (CMG) DNA helicase drives the release of condensin I complexes from chromatin and the activation or displacement of ..
  21. Rivas L, Blanco Ã, Torreira C, Repáraz A, Melcón C, Amado A. [Pontocerebellar hypoplasia secondary to CASK gene deletion: Case report]. Rev Chil Pediatr. 2017;88:529-533 pubmed publisher
    ..The genetic study (aCGH) showed heterozygous deletion on the X chromosome, affecting the CASK gene...
  22. Carvajal A, Vázquez Carretero M, García Miranda P, Peral M, Calonge M, Ilundáin A. Reelin expression is up-regulated in mice colon in response to acute colitis and provides resistance against colitis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:462-473 pubmed publisher
    ..does not modify Sp1 or Tbr1 mRNA abundance, but increases that of TGF-β1 and ApoER2, decreases that of CASK and DNMT1 and it also decreases the reelin promoter methylation...
  23. Fenwick A, Kliszczak M, Cooper F, Murray J, Sanchez Pulido L, Twigg S, et al. Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis. Am J Hum Genet. 2016;99:125-38 pubmed publisher
    ..CDC45 encodes a component of both the pre-initiation (preIC) and CMG helicase complexes, required for initiation of DNA replication origin firing and ongoing DNA synthesis during S-..
  24. Rogers M, Xiao Z, Shen B, Wang J, Schwen Z, Roppolo J, et al. Propranolol, but not naloxone, enhances spinal reflex bladder activity and reduces pudendal inhibition in cats. Am J Physiol Regul Integr Comp Physiol. 2015;308:R42-9 pubmed publisher
    ..During a cystrometrogram (CMG), PNS at 2T and 4T significantly (P < 0.05) increased bladder capacity from 58.0 ± 4.7% to 85.8 ± 10...
  25. Deiteren A, van der Linden L, de Wit A, Ceuleers H, Buckinx R, Timmermans J, et al. P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization. PLoS ONE. 2015;10:e0123810 pubmed publisher
    ..of P2X3 receptors (RT-PCR and immunohistochemistry) and the intracellular signalling molecules cdk5, csk and CASK (RT-PCR) were quantified in colonic tissue and dorsal root ganglia...
  26. Yeeles J, Deegan T, Janska A, Early A, Diffley J. Regulated eukaryotic DNA replication origin firing with purified proteins. Nature. 2015;519:431-5 pubmed publisher
    ..maintenance (MCM) complex is first loaded at replication origins during G1 phase, and then converted to the active CMG (Cdc45-MCM-GINS) helicase during S phase...
  27. Maximov A, Tang T, Bezprozvanny I. Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons. Mol Cell Neurosci. 2003;22:271-83 pubmed
    ..In biochemical experiments we demonstrated a possibility of InsP(3)R1-4.1N-CASK-syndecan-2 quaternary complex formation. From our findings we hypothesize that InsP(3)R1-4...
  28. Huang T, Hsueh Y. Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice. J Psychiatry Neurosci. 2017;42:37-47 pubmed
    Human genetic studies have indicated that mutations in calcium/calmodulin-dependent serine protein kinase (CASK) result in X-linked mental retardation and autism-spectrum disorders...
  29. Halimi M, Cheghabaleki Z, Modrek M, Delavari M. Temporal Dynamics of Phlebotomine Sand Flies Population in Response to Ambient Temperature Variation, Bam, Kerman Province of Iran. Ann Glob Health. 2016;82:824-831 pubmed publisher
    ..The MODIS land surface temperature product (LST; MODIS/Terra LST/E Monthly L3 Global 0.05Deg CMG [MOD11C3]) and land-based climatic data were used as explanatory variables...
  30. Maculins T, Nkosi P, Nishikawa H, Labib K. Tethering of SCF(Dia2) to the Replisome Promotes Efficient Ubiquitylation and Disassembly of the CMG Helicase. Curr Biol. 2015;25:2254-9 pubmed publisher
    Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase, which unwinds the parental DNA duplex at eukaryotic replication forks, is the key regulated step during replication termination but is poorly understood...
  31. Hansen S, Ehlers N, Zhu S, Thomsen M, Nielsen R, Liu D, et al. The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells. BMC Genomics. 2016;17:442 pubmed publisher
    ..Of these genes, CASK, POLA1, PRDX4, MED14 and PIGA were highly prioritized by the applied network-based gene ranking approach...
  32. Wyss L, Nilforoushan A, Williams D, Marx A, Sturla S. The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts. Nucleic Acids Res. 2016;44:6564-73 pubmed publisher
    ..this study, DNA adducts of biological relevance, O(6)-methylguanine (O(6)-MeG) and O(6)-carboxymethylguanine (O(6)-CMG), were characterized to be effective templates for the incorporation of benzimidazole-derived 2'-deoxynucleoside-5'-..
  33. Kanazawa K, Komiya Y, Nakamura K, Kobayashi N. Red luminescence control of Eu(iii) complexes by utilizing the multi-colored electrochromism of viologen derivatives. Phys Chem Chem Phys. 2017;19:16979-16988 pubmed publisher
    ..electroresponsive switching of red photoluminescence based on the electrochemical coloration of cyan-magenta-green (CMG) viologen components was achieved by combining a luminescent Eu3+ chelate and viologen derivatives, ..
  34. Sun Q, Kelly G. Post-translational modification of CASK leads to its proteasome-dependent degradation. Int J Biochem Cell Biol. 2010;42:90-7 pubmed publisher
    b>CASK is a member of the membrane-associated guanylate kinase family. In mammals it is an essential protein, as CASK knockout mice die after birth and its deletion in humans has developmental consequences...
  35. Takaya J, Kusunoki S, Ishimi Y. Protein interaction and cellular localization of human CDC45. J Biochem. 2013;153:381-8 pubmed publisher
    CDC45, which plays a role in eukaryotic DNA replication, is a member of the CMG (CDC45/MCM2-7/GINS) complex that is thought to function as a replicative DNA helicase. However, the biochemical properties of CDC45 are not fully understood...
  36. Watkins R, Patil R, Goult B, Thomas M, Gottlob I, Shackleton S. A novel interaction between FRMD7 and CASK: evidence for a causal role in idiopathic infantile nystagmus. Hum Mol Genet. 2013;22:2105-18 pubmed publisher
    ..molecular function, we used an IP-MS approach and identified the multi-domain plasma membrane scaffolding protein, CASK, as a FRMD7 interactor...
  37. Dobberfuhl A, Spettel S, Schuler C, Levin R, Dubin A, De E. Noxious electrical stimulation of the pelvic floor and vagina induces transient voiding dysfunction in a rabbit survival model of pelvic floor dystonia. Korean J Urol. 2015;56:837-44 pubmed publisher
    ..We developed a survival model of pelvic floor dysfunction in the rabbit and evaluated cystometric (CMG), electromyographic (EMG) and ambulatory voiding behavior...
  38. Bruck I, Pérez Arnaiz P, Colbert M, Kaplan D. Insights into the Initiation of Eukaryotic DNA Replication. Nucleus. 2015;6:449-54 pubmed publisher
    ..The replication fork helicase, called CMG for Cdc45-Mcm2-7, and GINS, assembles in S phase from the constituent Cdc45, Mcm2-7, and GINS proteins...
  39. Sandecká V, Hájek R, Pour L, Špička I, Ščudla V, Gregora E, et al. A first Czech analysis of 1887 cases with monoclonal gammopathy of undetermined significance. Eur J Haematol. 2017;99:80-90 pubmed publisher
    ..0 g/dL. Combining these factors, we propose a new risk model (CMG model). The risk of progression at 10 years was 1.6%, 16.9%, 22.9%, 39.4%, and 52...
  40. Pérez Arnaiz P, Bruck I, Colbert M, Kaplan D. An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-? to Mcm2-7. Nucleic Acids Res. 2017;45:7261-7275 pubmed publisher
    ..The replication fork helicase is composed of Cdc45, Mcm2-7 and GINS (CMG)...
  41. Borg J, Lopez Figueroa M, de Taddèo Borg M, Kroon D, Turner R, Watson S, et al. Molecular analysis of the X11-mLin-2/CASK complex in brain. J Neurosci. 1999;19:1307-16 pubmed
    A heterotrimeric complex containing Lin-10/X11alpha, Lin-2/CASK, and Lin-7 is evolutionarily conserved from worms to mammals...
  42. Boos D, Yekezare M, Diffley J. Identification of a heteromeric complex that promotes DNA replication origin firing in human cells. Science. 2013;340:981-4 pubmed publisher
    ..show that MTBP depletion by means of small interfering RNA inhibits DNA replication by preventing assembly of the CMG (Cdc45-MCM-GINS) holohelicase during origin firing...
  43. Pak C, Danko T, Zhang Y, Aoto J, ANDERSON G, Maxeiner S, et al. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell. 2015;17:316-28 pubmed publisher
    ..Moreover, both NRXN1 mutations increased the levels of CASK, a critical synaptic scaffolding protein that binds to neurexin-1...
  44. O Sullivan J, Comerford E, Rachidi W, Scott M, Hooper N, McMahon H. The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11α. Biochim Biophys Acta. 2015;1850:2213-21 pubmed publisher
    ..binding (PTB) domain, two PDZ (PSD_95, Drosophila disks-large, ZO-1) domains, a Munc Interacting (MI) domain and a CASK interacting region...
  45. Maric M, Mukherjee P, Tatham M, Hay R, Labib K. Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication. Cell Rep. 2017;18:3033-3042 pubmed publisher
    Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase is the key regulated step during DNA replication termination in eukaryotes, involving ubiquitylation of the Mcm7 helicase subunit, leading to a disassembly process that requires the ..
  46. Spiegel I, Salomon D, Erne B, Schaeren Wiemers N, Peles E. Caspr3 and caspr4, two novel members of the caspr family are expressed in the nervous system and interact with PDZ domains. Mol Cell Neurosci. 2002;20:283-97 pubmed
    ..cytoplasmic tails of Caspr3 and Caspr4 interacted differentially with PDZ domain-containing proteins of the CASK/Lin2-Veli/Lin7-Mint1/Lin10 complex...
  47. Chen T, Aure W, Cruz E, Malbas F, Teng H, Lu L, et al. Avian Plasmodium infection in field-collected mosquitoes during 2012-2013 in Tarlac, Philippines. J Vector Ecol. 2015;40:386-92 pubmed publisher
    ..juxtanucleare -GALLUS02, Tacy7 (Donana04), CXBIT01, Plasmodium species LIN2 New Zealand, and two unclassified lineages...
  48. Eichel C, Beuriot A, Chevalier M, Rougier J, Louault F, Dilanian G, et al. Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes. Circ Res. 2016;119:544-56 pubmed publisher
    ..To test the hypothesis that the MAGUK (membrane-associated guanylate kinase) protein CASK (calcium/calmodulin-dependent serine protein kinase) interacts with and regulates NaV1.5 in cardiac myocytes...
  49. Xu X, Wang J, Li M, Liu Y. TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin. J Biol Chem. 2016;291:22544-22558 pubmed
    ..kinase and via interactions with CDC45 and go-ichi-ni-san complex (GINS) to form the CDC45·MCM2-7·GINS (CMG) helicase complex...
  50. DeLuca S, Wallace D, Trucks M, Mukherjee K. A clinical series using intensive neurorehabilitation to promote functional motor and cognitive skills in three girls with CASK mutation. BMC Res Notes. 2017;10:743 pubmed publisher
    ..with microcephaly which produces mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH; OMIM# 300749)...
  51. Qi J, Su Y, Sun R, Zhang F, Luo X, Yang Z, et al. CASK inhibits ECV304 cell growth and interacts with Id1. Biochem Biophys Res Commun. 2005;328:517-21 pubmed
    Calcium/calmodulin-dependent serine protein kinase (CASK) is generally known as a scaffold protein...
  52. Bruck I, Kaplan D. Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex. J Biol Chem. 2011;286:18602-13 pubmed publisher
    The replication fork helicase in eukaryotic cells is comprised of Cdc45, Mcm2-7, and GINS (CMG complex)...
  53. Mori K, Noguchi M, Tobu S, Sato F, Mimata H, Tyagi P, et al. Age-related changes in bladder function with altered angiotensin II receptor mechanisms in rats. Neurourol Urodyn. 2016;35:908-913 pubmed publisher
    ..05). There was no significant difference in CMG parameters between 8W and 9M rats...
  54. Herrera M, Tognetti S, Riera A, Zech J, Clarke P, Fernández Cid A, et al. A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase. Nucleic Acids Res. 2015;43:10238-50 pubmed publisher
    ..CDK) direct with the help of a large number of helicase-activation factors the assembly of a Cdc45-MCM2-7-GINS (CMG) complex...
  55. Deegan T, Yeeles J, Diffley J. Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation. EMBO J. 2016;35:961-73 pubmed publisher
    The initiation of eukaryotic DNA replication requires the assembly of active CMG (Cdc45-MCM-GINS) helicases at replication origins by a set of conserved and essential firing factors...
  56. Zanobetti M, Prota A, Coppa A, Giordano L, Bigiarini S, Nazerian P, et al. Can non-invasive ventilation modify central venous pressure? Comparison between invasive measurement and ultrasonographic evaluation. Intern Emerg Med. 2017;12:1279-1285 pubmed publisher
    ..ventilation (NIV) consists in a breathing support that supplies a positive pressure in airways through a mask or a cask though not using an endotracheal prosthesis...
  57. Dunn P, Prigatano G, Szelinger S, Roth J, Siniard A, Claasen A, et al. A de novo splice site mutation in CASK causes FG syndrome-4 and congenital nystagmus. Am J Med Genet A. 2017;173:611-617 pubmed publisher
    Mutations in CASK cause X-linked intellectual disability, microcephaly with pontine and cerebellar hypoplasia, optic atrophy, nystagmus, feeding difficulties, GI hypomotility, and seizures...
  58. Douglas M, Diffley J. Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex. J Biol Chem. 2016;291:5879-88 pubmed publisher
    ..of eukaryotic DNA replication and contributes in some unknown way to the activation of the Cdc45-MCM-GINS (CMG) helicase...
  59. Rump P, Jazayeri O, van Dijk Bos K, Johansson L, van Essen A, Verheij J, et al. Whole-exome sequencing is a powerful approach for establishing the etiological diagnosis in patients with intellectual disability and microcephaly. BMC Med Genomics. 2016;9:7 pubmed publisher
    ..In seven other patients we found mutations in RAB3GAP1, RNASEH2B, KIF11, ERCC8, CASK, DYRK1A and BRCA2. In one of the sib-pairs, mutations were found in the RTTN gene...
  60. Zhang D, O Donnell M. The Eukaryotic Replication Machine. Enzymes. 2016;39:191-229 pubmed publisher
    ..The core replisome proteins of the eukaryote include: an 11-subunit CMG helicase, DNA polymerase alpha-primase, leading strand DNA polymerase epsilon, lagging strand DNA polymerase delta, ..
  61. Schauer G, O Donnell M. Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork. Proc Natl Acad Sci U S A. 2017;114:675-680 pubmed publisher
    ..Previous studies have established recruitment mechanisms whereby Cdc45-Mcm2-7-GINS (CMG) helicase binds Pol ε and tethers it to the leading strand, and PCNA (proliferating cell nuclear antigen) binds ..
  62. Margolis R, Abraham M, Gatchell S, Li S, Kidwai A, Breschel T, et al. cDNAs with long CAG trinucleotide repeats from human brain. Hum Genet. 1997;100:114-22 pubmed
    ..These genes are therefore candidates for diseases featuring anticipation, neurodegeneration, or abnormalities of neurodevelopment. ..
  63. Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty B, Bacal J, et al. Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest. Proc Natl Acad Sci U S A. 2016;113:E3639-48 pubmed publisher
    ..mini chromosome maintenance (Mcm) 2-7 complex, which is known to require phosphorylation by DDK to form an active CMG [Cdc45 (cell division cycle gene 45), Mcm2-7, GINS (Go, Ichi, Ni, and San)] helicase...
  64. Fallon L, Moreau F, Croft B, Labib N, Gu W, Fon E. Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J Biol Chem. 2002;277:486-91 pubmed
    ..truncated by a Parkinson's disease-causing mutation, functions as a class II PDZ-binding motif that binds CASK, the mammalian homolog of Caenorhabditis elegans Lin-2, but not other PDZ proteins in brain extracts...
  65. Suzuki T, Li W, Zhang J, Tian Q, Sakagami H, Usuda N, et al. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. Eur J Neurosci. 2005;21:339-50 pubmed
    ..These results suggest that TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins. ..
  66. Lewis J, Spenkelink L, Schauer G, Hill F, Georgescu R, O Donnell M, et al. Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome. Proc Natl Acad Sci U S A. 2017;114:10630-10635 pubmed publisher
    ..The minimal reconstituted leading-strand replisome requires 24 proteins, forming the CMG helicase, the Pol ? DNA polymerase, the RFC clamp loader, the PCNA sliding clamp, and the RPA single-stranded DNA ..
  67. Jin C, Zhang B, Wei Z, Ma B, Pan Q, Hu P. Effects of WD?3 on tumor growth and the expression of integrin ?v?3 and ERK1/2 in mice bearing human gastric cancer using the 18F?RGD PET/CT imaging system. Mol Med Rep. 2017;: pubmed publisher
    ..were randomly assigned into the following 4 groups (n=6 mice/group): Control group (CG), Chinese medicine group (CMG), Western medicine group (WMG) and Chinese and Western medicine combination group (CMG + WMG)...
  68. Wang G, Hong C, Yen T, Huang H, Ou Y, Huang T, et al. Transcriptional modification by a CASK-interacting nucleosome assembly protein. Neuron. 2004;42:113-28 pubmed
    b>CASK acts as a coactivator for Tbr-1, an essential transcription factor in cerebral cortex development. Presently, the molecular mechanism of the CASK coactivation effect is unclear...
  69. Nagata M, Ishino S, Yamagami T, Ogino H, Simons J, Kanai T, et al. The Cdc45/RecJ-like protein forms a complex with GINS and MCM, and is important for DNA replication in Thermococcus kodakarensis. Nucleic Acids Res. 2017;45:10693-10705 pubmed publisher
    ..In the eukaryotic replicative helicase complex, Cdc45 forms a complex with MCM and GINS, named as CMG (Cdc45-MCM-GINS). Cdc45 shares sequence similarity with bacterial RecJ...
  70. Zeng M, Ye F, Xu J, Zhang M. PDZ Ligand Binding-Induced Conformational Coupling of the PDZ-SH3-GK Tandems in PSD-95 Family MAGUKs. J Mol Biol. 2018;430:69-86 pubmed publisher
    ..Finally, we provide evidence showing that ligand binding-induced conformational coupling between PDZ and SH3-GK is a common feature for other MAGUKs including CASK and PALS1.
  71. Green M. Chromatin modifying gene mutations in follicular lymphoma. Blood. 2017;: pubmed publisher
    ..Next generation sequencing studies have identified chromatin modifying gene (CMG) mutations as a hallmark of FL, highlighting epigenetic modifiers as an attractive therapeutic target in this ..
  72. Hsueh Y, Sheng M. Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J Neurosci. 1999;19:7415-25 pubmed
    ..cell surface heparan sulfate proteoglycans interacts via their cytoplasmic C-terminal tail with the PDZ domain of CASK/LIN-2, a membrane-associated guanylate kinase homolog...
  73. Stevenson D, Laverty H, Wenwieser S, Douglas M, Wilson J. Mapping and expression analysis of the human CASK gene. Mamm Genome. 2000;11:934-7 pubmed
  74. Stiffler M, Grantcharova V, Sevecka M, MacBeath G. Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. J Am Chem Soc. 2006;128:5913-22 pubmed
  75. Nafzger S, Rougier J. Calcium/calmodulin-dependent serine protein kinase CASK modulates the L-type calcium current. Cell Calcium. 2017;61:10-21 pubmed publisher
    ..Calcium/calmodulin-dependent serine protein kinase (CASK), expressed in cardiac cells, has been identified as a regulator of Cav2...
  76. Hayashi S, Uehara D, Tanimoto K, Mizuno S, Chinen Y, Fukumura S, et al. Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). PLoS ONE. 2017;12:e0181791 pubmed publisher
    ..of CASK are associated with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH), especially in females...
  77. Wangler M, Yamamoto S, Chao H, Posey J, Westerfield M, Postlethwait J, et al. Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research. Genetics. 2017;207:9-27 pubmed publisher
    ..Network (UDN) (Supplemental Material, File S1) and UDN International (UDNI), the Centers for Mendelian Genomics (CMG), and the Canadian Rare Diseases Models and Mechanisms Network (RDMM)...
  78. Nagata M, Ishino S, Yamagami T, Simons J, Kanai T, Atomi H, et al. Possible function of the second RecJ-like protein in stalled replication fork repair by interacting with Hef. Sci Rep. 2017;7:16949 pubmed publisher
    ..GAN is probably a counterpart of Cdc45 in the eukaryotic CMG replicative helicase complex...
  79. Ebnet K, Schulz C, Meyer Zu Brickwedde M, Pendl G, Vestweber D. Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. J Biol Chem. 2000;275:27979-88 pubmed
    ..Although JAM did not interact with the single PDZ domains of ZO-1 or of CASK, we found that a ZO-1 fragment containing PDZ domains 2 and 3 bound to JAM in vitro in a PDZ domain-dependent ..
  80. Leonoudakis D, Conti L, Radeke C, McGuire L, Vandenberg C. A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. J Biol Chem. 2004;279:19051-63 pubmed
    ..and co-immunoprecipitations from brain and transfected cells, we demonstrated that a complex composed of SAP97, CASK, Veli, and Mint1 associates with Kir2 channels via the C-terminal PDZ-binding motif...
  81. Burglen L, Chantot Bastaraud S, Garel C, Milh M, Touraine R, Zanni G, et al. Spectrum of pontocerebellar hypoplasia in 13 girls and boys with CASK mutations: confirmation of a recognizable phenotype and first description of a male mosaic patient. Orphanet J Rare Dis. 2012;7:18 pubmed publisher
    ..been identified in patients, mostly females, presenting with intellectual disability, microcephaly and PCH (MICPCH)...
  82. Wei J, Fu Z, Fang M, Zhou Q, Zhao Q, Guo J, et al. High expression of CASK correlates with progression and poor prognosis of colorectal cancer. Tumour Biol. 2014;35:9185-94 pubmed publisher
    Calcium/calmodulin-dependent serine protein kinase (CASK), which localizes at cell-cell adhesion sites and binds to the heparan sulfate proteoglycan syndecan-2, is involved in cell proliferation, cytoskeletal remodeling, and cell ..
  83. Uzair B, Menaa F, Khan B, Mohammad F, Ahmad V, Djeribi R, et al. Isolation, purification, structural elucidation and antimicrobial activities of kocumarin, a novel antibiotic isolated from actinobacterium Kocuria marina CMG S2 associated with the brown seaweed Pelvetia canaliculata. Microbiol Res. 2018;206:186-197 pubmed publisher
    ..Crude extract filtrates of CMG S2 strain grew on Zobell marine agar (ZMA) had the most remarkable antimicrobial activity...
  84. Ruppe E, Cherkaoui A, Lazarevic V, Emonet S, Schrenzel J. Establishing Genotype-to-Phenotype Relationships in Bacteria Causing Hospital-Acquired Pneumonia: A Prelude to the Application of Clinical Metagenomics. Antibiotics (Basel). 2017;6: pubmed publisher
    Clinical metagenomics (CMg), referred to as the application of next-generation sequencing (NGS) to clinical samples, is a promising tool for the diagnosis of hospital-acquired pneumonia (HAP)...
  85. Straight S, Karnak D, Borg J, Kamberov E, Dare H, Margolis B, et al. mLin-7 is localized to the basolateral surface of renal epithelia via its NH(2) terminus. Am J Physiol Renal Physiol. 2000;278:F464-75 pubmed
    ..Coprecipitation experiments demonstrated that mLin-2/CASK binds to mLin-7, and immunofluorescent labeling showed that these proteins colocalized at the basolateral surface ..
  86. Schuh K, Uldrijan S, Gambaryan S, Roethlein N, Neyses L. Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK. J Biol Chem. 2003;278:9778-83 pubmed
    ..b>CASK (calcium/calmodulin-dependent serine protein kinase) contains a calmodulin-dependent protein kinase-like domain ..
  87. Daemi S, Ashkarran A, Bahari A, Ghasemi S. Gold nanocages decorated biocompatible amine functionalized graphene as an efficient dopamine sensor platform. J Colloid Interface Sci. 2017;494:290-299 pubmed publisher
    Nanocomposite of gold nanocages and chemically modified graphene oxide (GNCs/CMG) was synthesized in N,N-dimethylformamide (DMF) for sensitive detection of dopamine (DA)...
  88. Kannampalli P, Poli S, Boléa C, Sengupta J. Analgesic effect of ADX71441, a positive allosteric modulator (PAM) of GABAB receptor in a rat model of bladder pain. Neuropharmacology. 2017;126:1-11 pubmed publisher
    ..During cystometrogram (CMG) recordings, ADX71441 (i.p...
  89. Tabuchi K, Biederer T, Butz S, Sudhof T. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein. J Neurosci. 2002;22:4264-73 pubmed
    b>CASK, an adaptor protein of the plasma membrane, is composed of an N-terminal calcium/calmodulin-dependent protein (CaM) kinase domain, central PSD-95, Dlg, and ZO-1/2 domain (PDZ) and Src homology 3 (SH3) domains, and a C-terminal ..
  90. Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali E, et al. SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science. 2002;297:1525-31 pubmed
  91. Sabio G, Arthur J, Kuma Y, Peggie M, Carr J, Murray Tait V, et al. p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 2005;24:1134-45 pubmed
    ..This is likely to regulate the integrity of intercellular-junctional complexes, and cell shape and volume in response to osmotic stress. ..