Gene Symbol: CAPZB
Description: capping actin protein of muscle Z-line subunit beta
Alias: CAPB, CAPPB, CAPZ, F-actin-capping protein subunit beta, capZ beta, capping actin protein of muscle Z-line beta subunit, capping protein (actin filament) muscle Z-line, beta
Species: human
Products:     CAPZB

Top Publications

  1. Zhou Y, Xia S, Zhang J, Zhang Z. Simultaneously enhanced biopolymers production and sludge dewaterability of waste activated sludge by synergetic integration process of short-time aerobic digestion with cocoamidopropyl betaine and calcium oxide. Chemosphere. 2018;213:541-550 pubmed publisher synergetic integration process of the short-time aerobic digestion (STAD) with cocoamidopropyl betaine (CAPB) and calcium oxide (CaO). STAD could improve the biopolymers production by biosynthesis...
  2. Zhang X, Cheng X, Wu Y, Feng D, Qian Y, Chen L, et al. In Vitro and In Situ Characterization of the Intestinal Absorption of Capilliposide B and Capilliposide C from Lysimachia capillipes Hemsl. Molecules. 2019;24: pubmed publisher
    ..of this investigation was to determine the processes and mechanism of intestinal absorption for capilliposide B (CAPB) and capilliposide C (CAPC) from the Chinese herb, Lysimachia capillipes Hemsl...
  3. Pocaterra A, Santinon G, Romani P, Brian I, Dimitracopoulos A, Ghisleni A, et al. F-actin dynamics regulates mammalian organ growth and cell fate maintenance. J Hepatol. 2019;: pubmed publisher
    ..b>Capzb inactivation alters stress fiber and focal adhesion dynamics leading to enhanced myosin activity, increased ..
  4. Solís C, Russell B. CapZ integrates several signaling pathways in response to mechanical stiffness. J Gen Physiol. 2019;: pubmed publisher
    ..Here, we hypothesize that in muscle, the actin-capping protein (named CapZ) integrates signaling by a variety of pathways, including phosphorylation and phosphatidylinositol 4,5-bisphosphate ..
  5. Charpentier T, Thompson L, Liriano M, Varney K, Wilder P, Pozharski E, et al. The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography. J Mol Biol. 2010;396:1227-43 pubmed publisher
  6. Su C, Yu T, Zhao R, Wang Y, Jia H, Jing M, et al. Subclinical thyroid disease and single nucleotide polymorphisms in reproductive-age women in areas of Shanxi Province, China, where iodine exposure is excessive. Asia Pac J Clin Nutr. 2018;27:1366-1373 pubmed publisher
    ..was found among areas with various water iodine, whereas, TG (rs2252696), TSHR (rs4903957), CTLA-4 (rs231775), CAPZB (rs1472565), PDE4D (rs27178), and HLA (rs2517532) were significantly associated with various subclinical thyroid ..
  7. Zou W, Tan G, Jiang H, Vogtt K, Weaver M, Koenig P, et al. From well-entangled to partially-entangled wormlike micelles. Soft Matter. 2019;15:642-655 pubmed publisher
    ..The solutions contain sodium lauryl ethylene glycol sulfate (SLE1S), cocamidopropyl betaine (CAPB), and NaCl...
  8. Zanatta R, Ávila D, Miyamoto K, Torres C, Borges A. Influence of Surfactants and Fluoride against Enamel Erosion. Caries Res. 2019;53:1-9 pubmed publisher
    ..Sodium lauryl sulfate (SLS), polysorbate 20 (P20), and cocoamidopropyl betaine (CAPB) were tested, at concentrations of 1.0 and 1.5%, and associated or not with NaF (275 ppm)...
  9. Schroeter M, Orlova A, Egelman E, Beall B, Chalovich J. Organization of F-actin by Fesselin (avian smooth muscle synaptopodin 2). Biochemistry. 2013;52:4955-61 pubmed publisher
    ..Blockers of actin growth at the barbed end (cytochalasin D and CapZ) did not prevent fesselin from polymerizing actin...

More Information


  1. Jurek I, Góral I, Mierzyńska Z, Moniuszko Szajwaj B, Wojciechowski K. Effect of synthetic surfactants and soapwort (Saponaria officinalis L.) extract on skin-mimetic model lipid monolayers. Biochim Biophys Acta Biomembr. 2019;1861:556-564 pubmed publisher
    ..lauryl sulphate (SLS), sodium laureth sulphate (SLES), ammonium lauryl sulphate (ALS) and cocamidopropyl betaine (CAPB) on two model lipid monolayers is analyzed using surface pressure, surface dilatational rheology and fluorescence ..
  2. Eyileten C, Wicik Z, De Rosa S, Mirowska Guzel D, Soplinska A, Indolfi C, et al. MicroRNAs as Diagnostic and Prognostic Biomarkers in Ischemic Stroke-A Comprehensive Review and Bioinformatic Analysis. Cells. 2018;7: pubmed publisher
    ..of published results, identifying the ten most significant genes (HMGB1, YWHAZ, PIK3R1, STAT3, MAPK1, CBX5, CAPZB, THBS1, TNFRSF10B, RCOR1) associated with inflammation, blood coagulation, and platelet activation and targeted by ..
  3. Gahan M, Bowman S, Chevalier R, Rossi R, Nelson M, Roffey P, et al. Bacillus species at the Canberra Airport: A comparison of real-time polymerase chain reaction and massively parallel sequencing for identification. Forensic Sci Int. 2019;295:169-178 pubmed publisher
    ..anthracis virulence plasmids (cya and capB genes) and a single conserved region of the 16S rRNA gene...
  4. Basheva E, Danov K, Radulova G, Kralchevsky P, Xu H, Ung Y, et al. Properties of the micelles of sulfonated methyl esters determined from the stepwise thinning of foam films and by rheological measurements. J Colloid Interface Sci. 2019;538:660-670 pubmed publisher
    ..Moreover, addition of the zwitterionic surfactant cocamidopropyl betaine (CAPB) is expected to transform the small spherical micelles of SME into giant wormlike aggregates...
  5. Geyer C, Inselman A, Sunman J, Bornstein S, Handel M, Eddy E. A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice. Dev Biol. 2009;330:142-52 pubmed publisher
    ..CAPZA3 protein localization was altered in spermatids concurrent with altered localization of a unique CAPZB variant isoform and disruption of the filamentous actin (F-actin) network...
  6. Tian R, Wang H, Gish G, Petsalaki E, Pasculescu A, Shi Y, et al. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. Proc Natl Acad Sci U S A. 2015;112:E1594-603 pubmed publisher
    ..Among the cellular phosphoproteins influenced by CD28 signaling, CapZ-interacting protein (CapZIP), a regulator of the actin cytoskeleton, was implicated by functional studies...
  7. Tzocheva S, Danov K, Kralchevsky P, Georgieva G, Post A, Ananthapadmanabhan K. Solubility limits and phase diagrams for fatty alcohols in anionic (SLES) and zwitterionic (CAPB) micellar surfactant solutions. J Colloid Interface Sci. 2015;449:46-61 pubmed publisher
    ..of the anionic surfactant sodium laurylethersulfate (SLES) and the zwitterionic surfactant cocamidopropyl betaine (CAPB) at temperatures of 25, 30, 35 and 40 °C...
  8. Almohefer S, Levon J, Gregory R, Eckert G, Lippert F. Caries lesion remineralization with fluoride toothpastes and chlorhexidine - effects of application timing and toothpaste surfactant. J Appl Oral Sci. 2018;26:e20170499 pubmed publisher
    ..determine the effect of the type of toothpaste surfactant [sodium dodecyl sulfate (SDS) or cocamidopropyl betaine (CAPB)] on caries lesion remineralization associated with CHX rinsing...
  9. Mutso M, Morro A, Smedberg C, Kasvandik S, Aquilimeba M, Teppor M, et al. Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. Viruses. 2018;10: pubmed publisher was found that CHIKV nsP3 HVD can bind cytoskeletal proteins, including CD2AP, SH3KBP1, CAPZA1, CAPZA2 and CAPZB. The interaction with CD2AP was found to be most evident; its binding site was mapped to the second SH3 ligand-..
  10. Thorsen L, Kando C, Sawadogo H, Larsen N, Diawara B, Ouédraogo G, et al. Characteristics and phylogeny of Bacillus cereus strains isolated from Maari, a traditional West African food condiment. Int J Food Microbiol. 2015;196:70-8 pubmed publisher
    ..cereus strains. The M13-PCR group 1 isolates harboured poly-γ-D-glutamic acid capsule biosynthesis genes capA, capB and capC showing 99-100% identity with the environmental B. cereus isolate 03BB108...
  11. Jia Q, Bowen R, Dillon B, Maslesa Galic S, Chang B, Kaidi A, et al. Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. Sci Rep. 2018;8:7009 pubmed publisher
    ..Here we report F. tularensis LVS ?capB (Live Vaccine Strain with a deletion in capB)- and attenuated multi-deletional Listeria monocytogenes (Lm)-vectored ..
  12. Yamaguchi T, Suzuki S, Okamura S, Miura Y, Tsukimori A, Nakamura I, et al. Evolution and single-nucleotide polymorphisms in methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to vancomycin and daptomycin, based on determination of the complete genome. Antimicrob Agents Chemother. 2015;59:3585-7 pubmed publisher
    ..using next-generation sequencing, and only four single-nucleotide polymorphisms (SNPs) were identified, one each in capB (E58K), rpoB (H481Y), lytN (I16V), and mprF (V351E)...
  13. Shaughnessy C, Malajian D, Belsito D. Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to surfactants. J Am Acad Dermatol. 2014;70:704-708 pubmed publisher
    ..database were more likely than nonatopic patients to patch test positive to the surfactants cocamidopropyl betaine (CAPB) and cocamide diethanolamide (DEA), or to the surfactant precursor amidoamine...
  14. Zou W, Zhou Q, Zhang X, Mu L, Hu X. Characterization of the effects of trace concentrations of graphene oxide on zebrafish larvae through proteomic and standard methods. Ecotoxicol Environ Saf. 2018;159:221-231 pubmed publisher
    ..The abundances of 243 proteins, including proteins involved in endocytosis (e.g., cltcb, arf6, capzb and dnm1a), oxidative stress (e.g., gpx4b, sod2, and prdx1), cytoskeleton assembly (e.g...
  15. Matorras R, Quevedo S, Corral B, Prieto B, Exposito A, Mendoza R, et al. Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles. Arch Gynecol Obstet. 2018;297:1577-1586 pubmed publisher
    ..31 0.78) (among others, arginase-1, actin B, PARK-7, cofilin-1, stathmin, annexin-2 and CAPZB)...
  16. Eckley D, Schroer T. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Mol Biol Cell. 2003;14:2645-54 pubmed
    ..present in a protein complex localized at the pointed end of the Arp1 minifilament, whereas actin capping protein (CapZ) is present at the barbed end. Either might cooperate with conventional actin to cap Arp1...
  17. Burgoyne T, Morris E, Luther P. Three-Dimensional Structure of Vertebrate Muscle Z-Band: The Small-Square Lattice Z-Band in Rat Cardiac Muscle. J Mol Biol. 2015;427:3527-3537 pubmed publisher
    ..The reconstruction shows that the terminal 5-7nm of the actin filaments within the Z-band is devoid of any α-actinin links and is likely to be the location of capping protein CapZ.
  18. Lesov I, Tcholakova S, Kovadjieva M, Saison T, Lamblet M, Denkov N. Role of Pickering stabilization and bulk gelation for the preparation and properties of solid silica foams. J Colloid Interface Sci. 2017;504:48-57 pubmed publisher
    ..Cationic TTAB leads to particle-stabilized foams (Pickering stabilization) whereas zwitterionic CAPB - to surfactant-stabilized foams...
  19. Mi N, Chen Y, Wang S, Chen M, Zhao M, Yang G, et al. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nat Cell Biol. 2015;17:1112-23 pubmed publisher
    ..of actin puncta is disrupted by an actin polymerization inhibitor or by knocking down the actin-capping protein CapZβ, isolation membranes and omegasomes collapse into mixed-membrane bundles...
  20. Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, et al. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell. 2013;154:1047-1059 pubmed publisher
    ..We identify the F-actin-capping/severing proteins Cofilin, CapZ, and Gelsolin as essential gatekeepers that limit YAP/TAZ activity in cells experiencing low mechanical stresses, ..
  21. Wang L, Wang N, Mi D, Luo Y, Guo J. Poly-?-glutamic acid productivity of Bacillus subtilis BsE1 has positive function in motility and biocontrol against Fusarium graminearum. J Microbiol. 2017;55:554-560 pubmed publisher
    ..The pgsB (PGA-synthase-CapB gene) deleted mutant of BsE1 reduced ?-PGA yield and exhibited apparent decline of in vitro motile ability...
  22. Gahan M, Thomas R, Rossi R, Nelson M, Roffey P, Richardson M, et al. Background frequency of Bacillus species at the Canberra Airport: A 12 month study. Forensic Sci Int. 2015;257:142-8 pubmed publisher
    ..anthracis PL3 genomic marker, 24 for the cya (pXO1) plasmid marker and five for the capB (pXO2) plasmid marker...
  23. Hempel A, Kühl S, Rothe M, Rao Tata P, Sirbu I, Vainio S, et al. The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. Dev Biol. 2017;424:28-39 pubmed publisher
    ..We here place Rcsd1 downstream of Wnt11 during cardiac development thereby providing a novel mechanism for how non-canonical Wnt signalling regulates vertebrate cardiogenesis. ..
  24. Wang P, Zhou W. Rapid determination of cocamidopropyl betaine impurities in cosmetic products by core-shell hydrophilic interaction liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2016;1461:78-83 pubmed publisher
    Cocamidopropyl betaine (CAPB) is a common surfactant widely used in personal care products...
  25. Baker K, Kirkham S, Hálová L, Atkin J, Franz Wachtel M, Cobley D, et al. TOR complex 2 localises to the cytokinetic actomyosin ring and controls the fidelity of cytokinesis. J Cell Sci. 2016;129:2613-24 pubmed publisher
    ..known regulator of cytokinesis) controls CAR stability, modulates Acp1-Acp2 (the equivalent of the mammalian CAPZA-CAPZB) heterodimer formation and is essential for survival upon stress...
  26. Emam M, Abouelroos M, Gad F. Expression of calbindin-D9k and vitamin D receptor in the uterus of Egyptian buffalo during follicular and luteal phases. Acta Histochem. 2016;118:471-7 pubmed publisher follicular (n=12) and luteal (n=16) phases of estrous cycle to investigate the expression of calbindin-D9k (CaPB-9k) and vitamin D receptor (VDR). This study was done using avidin-biotin immunohistochemistry method...
  27. Rollason R, Wherlock M, Heath J, Heesom K, Saleem M, Welsh G. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2. Biosci Rep. 2016;36:e00302 pubmed publisher
    ..purification coupled with MS we demonstrate that INF2 interacts with profilin 2 and the F-actin capping protein, CapZ α-1. These interactions are increased by the presence of the disease causing mutations...
  28. Lin Y, Swanson E, Li J, Mkrtschjan M, Russell B. Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε. J Muscle Res Cell Motil. 2015;36:329-37 pubmed publisher
    ..myocytes (NRVM) were subjected to physiologic strain for analysis of the dynamics of the actin capping protein, CapZ, and its post-translational modifications (PTM)...
  29. Uslusoy F, Naziroglu M, Ciğ B. Inhibition of the TRPM2 and TRPV1 Channels through Hypericum perforatum in Sciatic Nerve Injury-induced Rats Demonstrates their Key Role in Apoptosis and Mitochondrial Oxidative Stress of Sciatic Nerve and Dorsal Root Ganglion. Front Physiol. 2017;8:335 pubmed publisher
    ..and ROS concentrations were reduced by HP, N-(p-amylcinnamoyl) anthranilic acid (ACA), and capsazepine (CapZ)...
  30. Dehghan Nayeri N, Eshghi P, Pour K, Rezaei Tavirani M, Omrani M, Gharehbaghian A. Differential expression pattern of protein markers for predicting chemosensitivity of dexamethasone-based chemotherapy of B cell acute lymphoblastic leukemia. Cancer Chemother Pharmacol. 2017;80:177-185 pubmed publisher
    ..Eventually, proteomic analysis revealed a combination of biomarkers, including capping proteins (CAPZA1 and CAPZB), chloride channel (CLIC1), purine nucleoside phosphorylase (PNP), and proteasome activator (PSME1), in response ..
  31. Wojtusik J, Wang Y, Pukazhenthi B. Pretreatment with cholesterol-loaded cyclodextrins prevents loss of motility associated proteins during cryopreservation of addra gazelle (Nanger dama ruficollis) spermatozoa. Cryobiology. 2018;81:74-80 pubmed publisher
    ..CLC pretreatment partially prevented the loss of various proteins involved in metabolism including CAPZB (gene = CAPZB), HS90A (gene = HSP90AA1), and PGAM2 (gene = PGAM2)...
  32. Taye M, Kim J, Yoon S, Lee W, Hanotte O, Dessie T, et al. Whole genome scan reveals the genetic signature of African Ankole cattle breed and potential for higher quality beef. BMC Genet. 2017;18:11 pubmed publisher
    ..Genes (CAPZB, COL9A2, PDGFRA, MAP3K5, ZNF410, and PKM2) involved in muscle structure and metabolism affect meat tenderness...
  33. Lin Y, Warren C, Li J, McKinsey T, Russell B. Myofibril growth during cardiac hypertrophy is regulated through dual phosphorylation and acetylation of the actin capping protein CapZ. Cell Signal. 2016;28:1015-24 pubmed publisher
    ..that actin filament assembly during cardiomyocyte growth is regulated by post-translational modifications (PTMs) of CapZ?1...
  34. Li W, Li M, Liao D, Lu X, Gu X, Zhang Q, et al. Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma. Oncotarget. 2016;7:55110-55127 pubmed publisher
    ..Interestingly, HBx?31 exerts this function via down-regulating Maspin, RhoGDI? and CAPZB, a set of putative metastasis-suppressors in HCC, in part, by enhancing the binding of transcriptional repressor, ..
  35. Verma S, Salwan R, Katoch S, Verma L, Chahota R, Dhar P, et al. The relationship between capsular type and OmpA of Pasteurella multocida is associated with the outcome of disease. Microb Pathog. 2016;101:68-75 pubmed publisher
    ..A cohort of pasteurellae comprising of OmpA(I-IV)-capB was recovered from diseased animals and OmpA(VI)-capA from healthy subjects. This study concludes that P...
  36. Hong F, Mohammad Rachidi S, Lundgren D, Han D, Huang X, Zhao H, et al. Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PLoS ONE. 2017;12:e0169260 pubmed publisher
    ..Wnt co-receptor LRP6, were confirmed, cell surface HSP receptor CD91, TLR4 pathway protein CD180, WDR1, GANAB and CAPZB were identified as potentially novel substrates of gp96...
  37. Shirzad Aski H, Tabatabaei M. Occurrence of virulence-associated genes in Pasteurella multocida isolates obtained from different hosts. Microb Pathog. 2016;96:52-7 pubmed publisher
    ..Multiplex PCR results revealed expression of capA, capD and capB genes in 81 (61.83%), 30 (22.90%) and 10 isolates (7.29%), respectively...
  38. Jia Q, Bowen R, Lee B, Dillon B, Maslesa Galic S, Horwitz M. Francisella tularensis Live Vaccine Strain deficient in capB and overexpressing the fusion protein of IglA, IglB, and IglC from the bfr promoter induces improved protection against F. tularensis respiratory challenge. Vaccine. 2016;34:4969-4978 pubmed publisher
    ..tularensis. Previously, we developed an LVS ?capB mutant that is significantly safer than LVS and provides potent protective immunity against F...
  39. Agarwal N, Kim C, Kunkalla K, Konno H, Tjendra Y, Kwon D, et al. Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. Blood. 2016;127:605-15 pubmed publisher
    ..By linking IKKβ-mediated nuclear factor-κB activity with GLI1, we identified a crosstalk between these 2 pathways that can inform the design of novel therapeutic strategies in DLBCL. ..
  40. Rawal R, Teumer A, Volzke H, Wallaschofski H, Ittermann T, Asvold B, et al. Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. Hum Mol Genet. 2012;21:3275-82 pubmed publisher
    ..polymorphisms of these four loci were located within PDE8B encoding phosphodiesterase 8B, upstream of CAPZB that encodes the ?-subunit of the barbed-end F-actin-binding protein, in a former 'gene desert' that was recently ..
  41. Gluecks I, Bethe A, Younan M, Ewers C. Molecular study on Pasteurella multocida and Mannheimia granulomatis from Kenyan Camels (Camelus dromedarius). BMC Vet Res. 2017;13:265 pubmed publisher
    ..Haemorrhagic Septicaemia (HS) specific sequences KTSP61/KTT72 but lacked HS-associated capsular type B and E genes capB and capE. This indicates circulation of HS strains in camels that lack established capsular types...
  42. Seghatoleslam A, Zambrano A, Millon R, Ganguli G, Argentini M, Cromer A, et al. Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. Biochem Biophys Res Commun. 2006;339:422-9 pubmed
    ..This novel human gene may represent a new target for cancer therapeutics. ..
  43. Türk M, Schroder R, Khuller K, Hofmann A, Berwanger C, Ludolph A, et al. Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients. Neurobiol Aging. 2017;56:213.e1-213.e5 pubmed publisher
    ..of VCP, WASH1, FAM21C, CCDC53, SWIP, strumpellin, F-actin capping protein of muscle Z-line alfa 1 (CAPZA1), and CAPZB genes was performed in 43 sporadic ALS/FTD patients...
  44. Hishiya A, Kitazawa T, Takayama S. BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. Circ Res. 2010;107:1220-31 pubmed publisher
    ..BAG3 regulates the structural stability of F-actin through the actin capping protein, CapZ?1, by promoting association between Hsc70 and CapZ?1...
  45. Hart M, Korshunova Y, Cooper J. Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. Cell Motil Cytoskeleton. 1997;38:120-32 pubmed
    ..Most tissues have both alpha1 and alpha2 isoforms but the ratio of alpha1:alpha2 varies widely. Together, these findings support the hypothesis that the CP alpha isoforms have conserved, unique and essential roles in vertebrates. ..
  46. Ergin G, Lbadaoui Darvas M, Takahama S. Molecular structure inhibiting synergism in charged surfactant mixtures: An atomistic molecular dynamics simulation study. Langmuir. 2017;: pubmed publisher
    ..surfactant-water mixtures of sodium dodecyl sulfate (SDS), lauryl betaine (C12B) and cocoamidopropyl betaine (CAPB) systems are studied using molecular simulation to understand the role of interactions among headgroups, tailgroups,..
  47. Xia S, Zhou Y, Eustance E, Zhang Z. Enhancement mechanisms of short-time aerobic digestion for waste activated sludge in the presence of cocoamidopropyl betaine. Sci Rep. 2017;7:13491 pubmed publisher
    Cocoamidopropyl betaine (CAPB), which is a biodegradable ampholytic surfactant, has recently been found to dramatically enhance the aerobic digestion of waste activated sludge (WAS) in short-time aerobic digestion (STAD) systems...
  48. Avenarius M, Krey J, Dumont R, Morgan C, Benson C, Vijayakumar S, et al. Heterodimeric capping protein is required for stereocilia length and width regulation. J Cell Biol. 2017;216:3861-3881 pubmed publisher
    ..Because dimension control of the inner ear's stereocilia is particularly precise, we studied the CAPZB subunit in hair cells...
  49. Zhan M, Chen G, Pan C, Gu Z, Zhao S, Liu W, et al. Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations. Hum Mol Genet. 2014;23:5505-17 pubmed publisher
    ..21 × 10(-10)), and we confirmed two previously reported TSH susceptibility loci near FOXE1 at 9q22.33 and near CAPZB at 1p36.13, respectively...
  50. Rainger J, Williamson K, Soares D, Truch J, Kurian D, Gillessen Kaesbach G, et al. A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum Mutat. 2017;38:942-946 pubmed publisher
    ..The LCP1 and TWF1 variants each resulted in only minor disturbance of actin interactions, and no further plausibly causative variants were identified in these genes on resequencing 380 unrelated individuals with OC. ..
  51. Barron Casella E, Torres M, Scherer S, Heng H, Tsui L, Casella J. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. J Biol Chem. 1995;270:21472-9 pubmed
    ..The human alpha 2 gene (CAPZA2) has been mapped to chromosome 7 position q31.2-q31.3 and the beta gene (CAPZB) to chromosome 1 region p36.1.
  52. Huber S, Remberger M, Kaj L, Schlabach M, Jörundsdóttir H, Vester J, et al. A first screening and risk assessment of pharmaceuticals and additives in personal care products in waste water, sludge, recipient water and sediment from Faroe Islands, Iceland and Greenland. Sci Total Environ. 2016;562:13-25 pubmed publisher
    ..Additives in PCPs were found to pose the largest risk to the aquatic environment. The surfactants CAPB and ATAC-C16 were found in concentrations resulting in risk factors up to 375 for CAPB and 165 for ATAC-C16 in ..
  53. Bior B, Ballif B. Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587. FEBS Lett. 2013;587:60-6 pubmed publisher
    ..Furthermore a Cin85 Ser587 phosphomimetic disrupts the Dab1-Cin85 complex without affecting the Cin85-CapZ complex...
  54. Wells C, Fawcett J, Traweger A, Yamanaka Y, Goudreault M, Elder K, et al. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Cell. 2006;125:535-48 pubmed
    ..We propose that Rich1 and Amot maintain TJ integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking. ..
  55. di Pietro F, Valon L, Li Y, Goïame R, Genovesio A, Morin X. An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z ? as an Essential Regulator of Spindle Orientation. Curr Biol. 2017;27:2452-2464.e8 pubmed publisher
    ..We further analyze the involvement of one novel regulator, the actin-capping protein CAPZB. Mechanistically, we show that CAPZB controls spindle orientation independently of its classical role in the actin ..
  56. Teumer A, Rawal R, Homuth G, Ernst F, Heier M, Evert M, et al. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. Am J Hum Genet. 2011;88:664-73 pubmed publisher
    ..Of these, two independent loci are located upstream of and within CAPZB, which encodes the ? subunit of the barbed-end F-actin binding protein that modulates actin polymerization, a ..
  57. Olavesen M, Bentley E, Mason R, Stephens R, Ragoussis J. Fine mapping of 39 ESTs on human chromosome 6p23-p25. Genomics. 1997;46:303-6 pubmed
    ..The order of known genes in this region is cen-CD83-ZNF40-EDN1-(GCNT2, CAPZB)-TFAP2-BMP6-DSP-tel.
  58. Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, et al. CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J Immunol. 2012;189:786-92 pubmed publisher
    ..Therefore, CD2AP positively regulates BDCA2/Fc?R1? signaling by forming a complex with SHIP1 to inhibit the E3 ubiquitin ligase Cbl. ..
  59. Ellinghaus D, Ellinghaus E, Nair R, Stuart P, Esko T, Metspalu A, et al. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet. 2012;90:636-47 pubmed publisher
    ..Our results show the usefulness of joint analyses of clinically distinct immune-mediated diseases and enlarge the map of shared genetic risk loci. ..
  60. Harbour M, Breusegem S, Seaman M. Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35. Biochem J. 2012;442:209-20 pubmed publisher
    ..Additionally, overexpression of the Fam21-tail results in cell-spreading defects, implicating the activity of the WASH complex in regulating the mobilization of membrane into the endosome-to-cell surface pathway. ..
  61. Datta M, Hernandez A, Schlicht M, Kahler A, DeGueme A, Dhir R, et al. Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. Mol Cancer. 2006;5:9 pubmed
    Genetic studies associated the CAPB locus with familial risk of brain and prostate cancers. We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signaling in Drosophila...
  62. Derivery E, Sousa C, Gautier J, Lombard B, Loew D, Gautreau A. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev Cell. 2009;17:712-23 pubmed publisher
    ..Together, these data suggest that the WASH molecular machine, integrating CP with a NPF, controls the fission of endosomes through an interplay between the forces generated by microtubule motors and actin polymerization. ..
  63. Kuhlman P, Fowler V. Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin. Biochemistry. 1997;36:13461-72 pubmed
    b>CapZ ("capping protein") is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and is proposed to function in regulating actin filament dynamics ..
  64. Soda T, Miyagawa Y, Ueda N, Takezawa K, Okuda H, Fukuhara S, et al. Systematic characterization of human testis-specific actin capping protein β3 as a possible biomarker for male infertility. Hum Reprod. 2017;32:514-522 pubmed publisher
    ..This work was supported by a Grant-in-Aid for Young Scientists (B) from the Japan Society for the Promotion of Science (JP16K20133). The authors declare no competing interests. ..
  65. Dutta P, Das S, Maiti S. Non diaphanous formin delphilin acts as a barbed end capping protein. Exp Cell Res. 2017;357:163-169 pubmed publisher
    ..binds to actin filaments, and Delphilin inhibits actin filament elongation like barbed end capping protein CapZ. In vitro, Delphilin stabilized actin filaments by inhibiting actin filament depolymerisation...
  66. Yang C, Pring M, Wear M, Huang M, Cooper J, Svitkina T, et al. Mammalian CARMIL inhibits actin filament capping by capping protein. Dev Cell. 2005;9:209-21 pubmed
    ..This phenotype is reversed by full-length mCARMIL but not mCARMIL lacking the domain that binds CP. Thus, mCARMIL is a key regulator of CP and has profound effects on cell behavior. ..
  67. Liu H, Atta S, Hartung J. Characterization and purification of proteins suitable for the production of antibodies against 'Ca. Liberibacter asiaticus'. Protein Expr Purif. 2017;139:36-42 pubmed publisher
    ..polyphosphate hydrolase (InvA), a portion of the major outer membrane protein (OmpA), a component of type IV pilus (CapB), the polysialic acid capsule expression protein (KpsA) and the outer membrane efflux protein (TolC)...
  68. Taoka M, Ichimura T, Wakamiya Tsuruta A, Kubota Y, Araki T, Obinata T, et al. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein. J Biol Chem. 2003;278:5864-70 pubmed
    ..with V-1, which were identified as the alpha and beta subunits of the capping protein (CP, alternatively called CapZ or beta-actinin). CP regulates actin polymerization by capping the barbed end of the actin filament. The V-1...
  69. Xiong F, Leonov S, Howard A, Xiong S, Zhang B, Mei L, et al. Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a beta-catenin-dependent manner. J Biol Chem. 2011;286:35061-70 pubmed publisher
    ..These results thus suggest a negative function for RAGE in endothelial cell membrane repair and reveal a new mechanism underlying RAGE regulation of F-actin remodeling and membrane resealing. ..
  70. Gholami A, Golestaneh M, Andalib Z. A new method for determination of cocamidopropyl betaine synthesized from coconut oil through spectral shift of Eriochrome Black T. Spectrochim Acta A Mol Biomol Spectrosc. 2018;192:122-127 pubmed publisher
    Cocamidopropyl betaine (CAPB) is a zwitterionic surfactant that is synthesized using coconut oil and usually supplied in form of an aqueous solution with 25-37% w/w...
  71. Huang D, Cao L, Zheng S. CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma. J Exp Clin Cancer Res. 2017;36:13 pubmed publisher
    ..Capping protein, a protein complex referred to as CapZ, is an actin-binding complex that can regulate actin cytoskeleton remodelling...
  72. Mukherjee K, Ishii K, Pillalamarri V, Kammin T, Atkin J, Hickey S, et al. Actin capping protein CAPZB regulates cell morphology, differentiation, and neural crest migration in craniofacial morphogenesis†. Hum Mol Genet. 2016;25:1255-70 pubmed publisher
    b>CAPZB is an actin-capping protein that caps the growing end of F-actin and modulates the cytoskeleton and tethers actin filaments to the Z-line of the sarcomere in muscles...
  73. Soto Pedre E, Siddiqui M, Doney A, Palmer C, Pearson E, Leese G. Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study (GoDARTS). Pharmacogenet Genomics. 2017;27:356-362 pubmed publisher
    ..For serum TSH, we confirmed 12 SNPs previously reported at PDE8B, CAPZB, PDE10A, LOC105371356, NR3C2, VEGFA, IGFBP5, INSR, PRDM11, NFIA, ITPK1 and ABO...
  74. Mukaihara K, Suehara Y, Kohsaka S, Kubota D, Toda Ishii M, Akaike K, et al. Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma. BMC Cancer. 2016;16:206 pubmed publisher
    A previous proteomics study demonstrated the overexpression of F-actin capping protein subunit beta (CAPZB) in tissue specimens of epithelioid sarcoma (EpiS). The aim of the present study was to elucidate the function of CAPZB in EpiS...