Gene Symbol: CAPZA2
Description: capping actin protein of muscle Z-line subunit alpha 2
Alias: CAPPA2, CAPZ, F-actin-capping protein subunit alpha-2, F-actin capping protein alpha-2 subunit, capZ alpha-2, capping actin protein of muscle Z-line alpha subunit 2, capping protein (actin filament) muscle Z-line, alpha 2
Species: human
Products:     CAPZA2

Top Publications

  1. Janku F, Diamond E, Goodman A, Kandadai Raghavan V, Barnes T, Kato S, et al. Molecular Profiling of Tumor Tissue and Plasma Cell-Free DNA from Patients with Non-Langerhans Cell Histiocytosis. Mol Cancer Ther. 2019;: pubmed publisher
    ..MAP2K1, MAP2K2, NF1 and RAS mutations; RAF1 or ERBB2 amplifications; LMNA-NTRK1 (TRK inhibitor-sensitive) and CAPZA2-BRAF fusions...
  2. Pocaterra A, Santinon G, Romani P, Brian I, Dimitracopoulos A, Ghisleni A, et al. F-actin dynamics regulates mammalian organ growth and cell fate maintenance. J Hepatol. 2019;: pubmed publisher
    ..Here we show that the F-actin capping protein CAPZ is a critical negative regulator of actomyosin contractility and mechanotransduction...
  3. Solís C, Russell B. CapZ integrates several signaling pathways in response to mechanical stiffness. J Gen Physiol. 2019;: pubmed publisher
    ..Here, we hypothesize that in muscle, the actin-capping protein (named CapZ) integrates signaling by a variety of pathways, including phosphorylation and phosphatidylinositol 4,5-bisphosphate ..
  4. Schroeter M, Orlova A, Egelman E, Beall B, Chalovich J. Organization of F-actin by Fesselin (avian smooth muscle synaptopodin 2). Biochemistry. 2013;52:4955-61 pubmed publisher
    ..Blockers of actin growth at the barbed end (cytochalasin D and CapZ) did not prevent fesselin from polymerizing actin...
  5. Charpentier T, Thompson L, Liriano M, Varney K, Wilder P, Pozharski E, et al. The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography. J Mol Biol. 2010;396:1227-43 pubmed publisher
  6. Tian R, Wang H, Gish G, Petsalaki E, Pasculescu A, Shi Y, et al. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor. Proc Natl Acad Sci U S A. 2015;112:E1594-603 pubmed publisher
    ..Among the cellular phosphoproteins influenced by CD28 signaling, CapZ-interacting protein (CapZIP), a regulator of the actin cytoskeleton, was implicated by functional studies...
  7. Geyer C, Inselman A, Sunman J, Bornstein S, Handel M, Eddy E. A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice. Dev Biol. 2009;330:142-52 pubmed publisher
    ..the mutant phenotype of repro32/repro32 sperm and regulation of F-actin dynamics by a spermatogenic cell-specific CAPZ heterodimer is essential for removal of the cytoplasm and maintenance of midpiece integrity during spermiation in ..
  8. Mutso M, Morro A, Smedberg C, Kasvandik S, Aquilimeba M, Teppor M, et al. Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus. Viruses. 2018;10: pubmed publisher
    ..proteomics, it was found that CHIKV nsP3 HVD can bind cytoskeletal proteins, including CD2AP, SH3KBP1, CAPZA1, CAPZA2 and CAPZB...
  9. Eckley D, Schroer T. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Mol Biol Cell. 2003;14:2645-54 pubmed
    ..present in a protein complex localized at the pointed end of the Arp1 minifilament, whereas actin capping protein (CapZ) is present at the barbed end. Either might cooperate with conventional actin to cap Arp1...

More Information


  1. Lin Y, Warren C, Li J, McKinsey T, Russell B. Myofibril growth during cardiac hypertrophy is regulated through dual phosphorylation and acetylation of the actin capping protein CapZ. Cell Signal. 2016;28:1015-24 pubmed publisher
    ..that actin filament assembly during cardiomyocyte growth is regulated by post-translational modifications (PTMs) of CapZ?1...
  2. Mi N, Chen Y, Wang S, Chen M, Zhao M, Yang G, et al. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nat Cell Biol. 2015;17:1112-23 pubmed publisher
    ..of actin puncta is disrupted by an actin polymerization inhibitor or by knocking down the actin-capping protein CapZβ, isolation membranes and omegasomes collapse into mixed-membrane bundles...
  3. Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, et al. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell. 2013;154:1047-1059 pubmed publisher
    ..We identify the F-actin-capping/severing proteins Cofilin, CapZ, and Gelsolin as essential gatekeepers that limit YAP/TAZ activity in cells experiencing low mechanical stresses, ..
  4. Hempel A, Kühl S, Rothe M, Rao Tata P, Sirbu I, Vainio S, et al. The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis. Dev Biol. 2017;424:28-39 pubmed publisher
    ..We here place Rcsd1 downstream of Wnt11 during cardiac development thereby providing a novel mechanism for how non-canonical Wnt signalling regulates vertebrate cardiogenesis. ..
  5. Lin Y, Swanson E, Li J, Mkrtschjan M, Russell B. Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε. J Muscle Res Cell Motil. 2015;36:329-37 pubmed publisher
    ..myocytes (NRVM) were subjected to physiologic strain for analysis of the dynamics of the actin capping protein, CapZ, and its post-translational modifications (PTM)...
  6. Tamura R, Yoshihara K, Yamawaki K, Suda K, Ishiguro T, Adachi S, et al. Novel kinase fusion transcripts found in endometrial cancer. Sci Rep. 2015;5:18657 pubmed publisher
    ..fusion candidates, we focused on three in-frame kinase fusion transcripts that retain a kinase domain (CPQ-PRKDC, CAPZA2-MET, and VGLL4-PRKG1)...
  7. Uslusoy F, Naziroglu M, Ciğ B. Inhibition of the TRPM2 and TRPV1 Channels through Hypericum perforatum in Sciatic Nerve Injury-induced Rats Demonstrates their Key Role in Apoptosis and Mitochondrial Oxidative Stress of Sciatic Nerve and Dorsal Root Ganglion. Front Physiol. 2017;8:335 pubmed publisher
    ..and ROS concentrations were reduced by HP, N-(p-amylcinnamoyl) anthranilic acid (ACA), and capsazepine (CapZ)...
  8. Ohishi T, Yoshida H, Katori M, Migita T, Muramatsu Y, Miyake M, et al. Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion. Cancer Res. 2017;77:2328-2338 pubmed publisher
    ..TNKS1BP1 bound the actin-capping protein CapZA2. TNKS1BP1 depletion dissociated CapZA2 from the cytoskeleton, leading to cofilin phosphorylation and enhanced cell ..
  9. Burgoyne T, Morris E, Luther P. Three-Dimensional Structure of Vertebrate Muscle Z-Band: The Small-Square Lattice Z-Band in Rat Cardiac Muscle. J Mol Biol. 2015;427:3527-3537 pubmed publisher
    ..The reconstruction shows that the terminal 5-7nm of the actin filaments within the Z-band is devoid of any α-actinin links and is likely to be the location of capping protein CapZ.
  10. Rollason R, Wherlock M, Heath J, Heesom K, Saleem M, Welsh G. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2. Biosci Rep. 2016;36:e00302 pubmed publisher
    ..purification coupled with MS we demonstrate that INF2 interacts with profilin 2 and the F-actin capping protein, CapZ α-1. These interactions are increased by the presence of the disease causing mutations...
  11. Agarwal N, Kim C, Kunkalla K, Konno H, Tjendra Y, Kwon D, et al. Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. Blood. 2016;127:605-15 pubmed publisher
    ..By linking IKKβ-mediated nuclear factor-κB activity with GLI1, we identified a crosstalk between these 2 pathways that can inform the design of novel therapeutic strategies in DLBCL. ..
  12. Kwon M, Kim R, Song K, Jeon S, Jeong H, Kim J, et al. Genes co-amplified with ERBB2 or MET as novel potential cancer-promoting genes in gastric cancer. Oncotarget. 2017;8:92209-92226 pubmed publisher
    ..Correlation analysis of CNAs and gene expression levels identified CAPZA2 (co-amplified with MET) and genes GRB7, MIEN1, PGAP3, and STARD3 (co-..
  13. Huang D, Cao L, Zheng S. CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma. J Exp Clin Cancer Res. 2017;36:13 pubmed publisher
    ..Capping protein, a protein complex referred to as CapZ, is an actin-binding complex that can regulate actin cytoskeleton remodelling...
  14. Yang C, Pring M, Wear M, Huang M, Cooper J, Svitkina T, et al. Mammalian CARMIL inhibits actin filament capping by capping protein. Dev Cell. 2005;9:209-21 pubmed
    ..This phenotype is reversed by full-length mCARMIL but not mCARMIL lacking the domain that binds CP. Thus, mCARMIL is a key regulator of CP and has profound effects on cell behavior. ..
  15. Inman K, Yang R, Rustandi R, Miller K, Baldisseri D, Weber D. Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12. J Mol Biol. 2002;324:1003-14 pubmed reported for Ca(2+)-loaded S100B bound to a 12-residue peptide, TRTK-12, from the actin capping protein CapZ (alpha1 or alpha2 subunit, residues 265-276: TRTKIDWNKILS)...
  16. Miyagawa Y, Tanaka H, Iguchi N, Kitamura K, Nakamura Y, Takahashi T, et al. Molecular cloning and characterization of the human orthologue of male germ cell-specific actin capping protein alpha3 (cpalpha3). Mol Hum Reprod. 2002;8:531-9 pubmed
    ..CPalpha3 may play a physiologically important role in sperm architecture as well as in fertility of the human male. ..
  17. Dutta P, Das S, Maiti S. Non diaphanous formin delphilin acts as a barbed end capping protein. Exp Cell Res. 2017;357:163-169 pubmed publisher
    ..binds to actin filaments, and Delphilin inhibits actin filament elongation like barbed end capping protein CapZ. In vitro, Delphilin stabilized actin filaments by inhibiting actin filament depolymerisation...
  18. Avenarius M, Krey J, Dumont R, Morgan C, Benson C, Vijayakumar S, et al. Heterodimeric capping protein is required for stereocilia length and width regulation. J Cell Biol. 2017;216:3861-3881 pubmed publisher
    ..Each of these actin structures relies on heterodimeric capping protein (CAPZ), which blocks actin polymerization at barbed ends...
  19. Barron Casella E, Torres M, Scherer S, Heng H, Tsui L, Casella J. Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. J Biol Chem. 1995;270:21472-9 pubmed
    ..The human alpha 2 gene (CAPZA2) has been mapped to chromosome 7 position q31.2-q31.3 and the beta gene (CAPZB) to chromosome 1 region p36.1.
  20. Hart M, Korshunova Y, Cooper J. Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. Cell Motil Cytoskeleton. 1997;38:120-32 pubmed
    ..Most tissues have both alpha1 and alpha2 isoforms but the ratio of alpha1:alpha2 varies widely. Together, these findings support the hypothesis that the CP alpha isoforms have conserved, unique and essential roles in vertebrates. ..