CAPN1

Summary

Gene Symbol: CAPN1
Description: calpain 1, (mu/I) large subunit
Alias: CANP, CANP1, CANPL1, muCANP, muCL, CANP 1, calcium-activated neutral proteinase 1, calpain mu-type, calpain, large polypeptide L1, calpain-1 catalytic subunit, calpain-1 large subunit, cell proliferation-inducing gene 30 protein, cell proliferation-inducing protein 30, micromolar-calpain
Species: human

Top Publications

  1. ncbi Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone
    Voahanginirina Randriamboavonjy
    Vascular Signaling Group, and Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Circulation 117:52-60. 2008
  2. ncbi The calpain system
    Darrell E Goll
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    Physiol Rev 83:731-801. 2003
  3. ncbi The calpain family and human disease
    Y Huang
    Laboratory of Neuro biochemistry, Dept of CNS Molecular Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Trends Mol Med 7:355-62. 2001
  4. pmc Calpain-1 cleaves and activates caspase-7
    Juliette Gafni
    Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 284:25441-9. 2009
  5. ncbi Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain
    Shirley Gil-Parrado
    Abteilung für Klinische Chemie und Klinische Biochemie, Chirurgische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität, Nussbaumstrasse 20, D 80336 Munich, Germany
    J Biol Chem 278:16336-46. 2003
  6. ncbi Calpain cleavage regulates the protein stability of p73
    Eliana Munarriz
    Medical Research Council, Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 333:954-60. 2005
  7. ncbi Purification and characterization of calcium-activated neutral proteinase from calf thymus
    M Schwenk
    Fachrichtung Physiologische Chemie, , Homburg Saar, Bundesrepublik Deutschland
    Z Naturforsch C 43:679-85. 1988
  8. doi Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states
    Daniel J Macqueen
    Scottish Oceans Institute, University of St Andrews, Fife, UK
    Gene 453:45-58. 2010
  9. ncbi Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin
    Jörg Reichrath
    Department of Dermatology, University of Saarland, Homburg, Germany
    J Pathol 199:509-16. 2003
  10. doi Production and processing studies on calpain-system gene markers for tenderness in Brahman cattle: 2. Objective meat quality
    L M Cafe
    Australian Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, New South Wales 2351, Australia
    J Anim Sci 88:3059-69. 2010

Detail Information

Publications164 found, 100 shown here

  1. ncbi Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone
    Voahanginirina Randriamboavonjy
    Vascular Signaling Group, and Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Circulation 117:52-60. 2008
    ..Platelets from patients with type 2 diabetes mellitus display hyperaggregability and increased thrombogenic potential...
  2. ncbi The calpain system
    Darrell E Goll
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    Physiol Rev 83:731-801. 2003
    ..Deregulated calpain activity following loss of Ca2+ homeostasis results in tissue damage in response to events such as myocardial infarcts, stroke, and brain trauma...
  3. ncbi The calpain family and human disease
    Y Huang
    Laboratory of Neuro biochemistry, Dept of CNS Molecular Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Trends Mol Med 7:355-62. 2001
    ..This review describes our current understanding of the calpain family members and their mechanistic linkages to the aforementioned diseases as well as other emerging pathological conditions...
  4. pmc Calpain-1 cleaves and activates caspase-7
    Juliette Gafni
    Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 284:25441-9. 2009
    ..Our studies suggest the calpain-activated form of caspase-7 has unique enzymatic activity, localization, and binding affinity when compared with the caspase-activated form...
  5. ncbi Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain
    Shirley Gil-Parrado
    Abteilung für Klinische Chemie und Klinische Biochemie, Chirurgische Klinik Innenstadt, Klinikum der Ludwig Maximilians Universität, Nussbaumstrasse 20, D 80336 Munich, Germany
    J Biol Chem 278:16336-46. 2003
    ..We propose that intracellular localization and in particular membrane targeting of activated calpain, but not dissociation of its intact subunits, contribute to regulate its proteolytic activity in vivo...
  6. ncbi Calpain cleavage regulates the protein stability of p73
    Eliana Munarriz
    Medical Research Council, Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 333:954-60. 2005
    ..This suggests that calpains may play a physiological role in the regulation of p73 protein stability...
  7. ncbi Purification and characterization of calcium-activated neutral proteinase from calf thymus
    M Schwenk
    Fachrichtung Physiologische Chemie, , Homburg Saar, Bundesrepublik Deutschland
    Z Naturforsch C 43:679-85. 1988
    A calcium-activated neutral proteinase (CANP) was prepared from the soluble fraction of calf thymus and purified to electrophoretical homogeneity...
  8. doi Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states
    Daniel J Macqueen
    Scottish Oceans Institute, University of St Andrews, Fife, UK
    Gene 453:45-58. 2010
    ..Transcripts for capn1, capn2-like and capn11 were widely detected across eleven halibut tissues, whereas capn3 was detected in striated ..
  9. ncbi Different expression patterns of calpain isozymes 1 and 2 (CAPN1 and 2) in squamous cell carcinomas (SCC) and basal cell carcinomas (BCC) of human skin
    Jörg Reichrath
    Department of Dermatology, University of Saarland, Homburg, Germany
    J Pathol 199:509-16. 2003
    ..Two major isoenzymes are known- micro -calpain (CAPN1) and m-calpain (CAPN2)-requiring micromolar and millimolar calcium concentrations for activation, respectively...
  10. doi Production and processing studies on calpain-system gene markers for tenderness in Brahman cattle: 2. Objective meat quality
    L M Cafe
    Australian Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, New South Wales 2351, Australia
    J Anim Sci 88:3059-69. 2010
    ..Gene marker status for mu-calpain (CAPN1-4751 and CAPN1-316) was also determined for inclusion in statistical analyses...
  11. ncbi Bovine mu-calpain (CAPN1) gene: new SNP within intron 14
    Edyta Juszczuk-Kubiak
    Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05 552 Wolka Kosowska, Poland
    J Appl Genet 45:457-60. 2004
    ..In this study a new single nucleotide polymorphism (SNP) was found within intron 14 of the bovine CAPN1 gene, being transition C --> T at position 4685 nt (consensus sequence - GenBank No...
  12. pmc Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity
    Matthew B Bevers
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neurochem 108:1237-50. 2009
    ..catalytic subunit of m-calpain (capn2 ) was found to be 50-fold higher than for the mu-calpain catalytic subunit (capn1) based on quantitative real-time PCR...
  13. pmc m-Calpain is required for preimplantation embryonic development in mice
    Previn Dutt
    Division of Cancer Biology and Genetics, Queen s University Cancer Research Institute, Queen s University, Kingston, Ontario K7L 3N6, Canada
    BMC Dev Biol 6:3. 2006
    ..These heterodimeric enzymes are composed of distinct catalytic subunits, encoded by Capn1 (mu-calpain) or Capn2 (m-calpain), and a common regulatory subunit encoded by Capn4...
  14. ncbi Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord
    J Li
    Laboratory for Molecular Neuroscience, Mailman Research Center, McLean Hospital, Belmont, Massachusetts, USA
    J Neurobiol 30:177-91. 1996
    The family of calpains (CANP or calcium activated neutral proteases) and their endogenous inhibitor calpastatin have been implicated in many neural functions; however, functional distinctions between the major calpain isoforms, calpain I ..
  15. ncbi Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreas
    Maria E Sabbatini
    Cátedras de Fisiopatología, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Physiol Gastrointest Liver Physiol 292:G349-57. 2007
    ..ANF response was mimicked by cANP (4-23 amide) and abolished by pertussis toxin, strongly supporting NPR-C receptor activation...
  16. doi The use of parsimony network analysis for the formal delineation of phylogenetic species of yeasts: Candida apicola, Candida azyma, and Candida parazyma sp. nov., cosmopolitan yeasts associated with floricolous insects
    Marc André Lachance
    Department of Biology, University of Western Ontario, London, ON, N6A 5B7, Canada
    Antonie Van Leeuwenhoek 97:155-70. 2010
    ..Two strains, MUCL 45721 and CBS 4353, were excluded from the species, but there was no evident justification to subdivide the rest...
  17. doi Stimulation of natriuretic peptide receptor C attenuates accumulation of reactive oxygen species and nitric oxide synthesis in ammonia-treated astrocytes
    Marta Skowronska
    Department of Neurotoxicology, Mossakowski Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    J Neurochem 115:1068-76. 2010
    ..natriuretic peptide (ANP), natriuretic peptide C and a selective natriuretic peptide receptor (NPR)-C ligand, cANP((4-23),) each decreased the total ROS content both in control cells and cells treated with ammonia...
  18. ncbi Muscle contribution to elbow joint valgus stability
    Fang Lin
    Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL 60611, USA
    J Shoulder Elbow Surg 16:795-802. 2007
    ..stress of the elbow can result in excessive strain or rupture of the native medial ulnar collateral ligament (MUCL)...
  19. ncbi Effects of ethylene glycol tetraacetic acid, A23187 and calmodulin, calcium activated neutral proteinase antagonists on melatonin secretion in perifused chick pineal gland
    M T Agapito
    Department Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Valladolid, Spain
    Neurosci Lett 245:143-6. 1998
    ..to involve the release of calcium from intracellular stores, calmodulin and calcium-activated neutral protease (CANP)...
  20. ncbi Description of primordial germ cells, oogonia, oocytes and embryo-like growth in squash preparations of tissues from hematological malignancies
    H Logothetou-Rella
    Department of Experimental Physiology, Medical School, University of Athens, Greece
    Histol Histopathol 11:965-84. 1996
    ..The results are discussed in terms of stem cell renewal according to the events: primordial germ cells-gametes-fertilization-embryos-primordial germ cells...
  21. doi Effect of culturing processes and copper addition on laccase production by the white-rot fungus Fomes fomentarius MUCL 35117
    M Neifar
    Unité enzymes et bioconversion, Ecole Nationale d Ingenieurs de Sfax, Sfax, Tunisia
    Lett Appl Microbiol 49:73-8. 2009
    ..To produce high laccase activities from the white-rot fungus Fomes fomentarius...
  22. doi Mycoparasitism of arbuscular mycorrhizal fungi: a pathway for the entry of saprotrophic fungi into roots
    Nathalie De Jaeger
    Earth and Life Institute, Mycology, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    FEMS Microbiol Ecol 73:312-22. 2010
    ..Microcosm experiments allowing interactions between Glomus sp. MUCL 41833 placed in a clade that contains the recently described species Glomus irregulare and T...
  23. ncbi A putative role for calpain in demyelination associated with optic neuritis
    N L Banik
    Department of Neurology, Medical University of South Carolina, Charleston 29425, USA
    Histol Histopathol 14:649-56. 1999
    ..Thus, increased activity and translational expression of calpain in optic neuritis may be integral to the pathogenesis of this disorder...
  24. ncbi Suppression of Pythium spp. by Trichoderma spp. during germination of tomato seeds in soilless growing media
    R Aerts
    Department of Industrial Engineering and Biotechnology, Katholieke Hogeschool Kempen, Kleinhoefstraat 4, 2440 Geel, Belgium
    Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet 67:343-51. 2002
    ..harzianum (Tri 003) and Trichoderma sp. (KHK) and two isolates of Pythium spp.: P. ultimum (MUCL) en P. aphanidermatum (HRI, UK) were used. Propamocarb was used as a chemical standard...
  25. ncbi The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation
    Martine Dunnwald
    Department of Oral Biology, University of Washington, Seattle, WA, USA
    Exp Dermatol 12:245-54. 2003
    ..this study, we report refined mapping of the mouse ichq locus and consideration of the candidate genes: calpain 1 (Capn1), phospholipase C beta 3 (Plcb3), and Rela and Ikka/Chuk that encode components of the nuclear factor-kappa B (NF-..
  26. ncbi Attachment of different soil bacteria to arbuscular mycorrhizal fungal extraradical hyphae is determined by hyphal vitality and fungal species
    Jonas F Toljander
    Department of Forest Mycology and Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    FEMS Microbiol Lett 254:34-40. 2006
    ..b>MUCL 43205 and Glomus intraradices MUCL 43194 was examined...
  27. pmc Gibberella xylarioides sensu lato from Coffea canephora: a new mating population in the Gibberella fujikuroi species complex
    Pascale C E Lepoint
    Unité de phytopathologie, Universite Catholique de Louvain, Croix du Sud 2 3, B 1348 Louvain la Neuve, Belgium
    Appl Environ Microbiol 71:8466-71. 2005
    ..xylarioides sensu lato constitutes a new biological species within the G. fujikuroi complex. MUCL 44532/MUCL 43887 and MUCL 35223/MUCL 44549 are proposed as G...
  28. ncbi The candicidin gene cluster from Streptomyces griseus IMRU 3570
    Ana Belén Campelo
    Departamento de Ecologia, Genética y Microbiología, Area de Microbiologia, Facultad de Biologia, Universidad de Leon, 24071 Leon, Spain
    Microbiology 148:51-9. 2002
    ..Of particular interest is the presence of the CanP1 loading domain (the first described as responsible for the activation of an aromatic starter unit) and the ..
  29. ncbi Anabolic effects of feeding beta2-adrenergic agonists on rainbow trout muscle proteases and proteins
    Mohamed Salem
    Division of Animal and Veterinary Sciences, West Virginia University, Morgantown, WV 26506 6108, USA
    Comp Biochem Physiol A Mol Integr Physiol 144:145-54. 2006
    ..RACT feeding significantly increased mRNA transcripts of the calpain catalytic subunit (Capn1), the regulatory subunit (cpns), and the calpastatin large isoform (CAST-L), without affecting the calpain enzyme ..
  30. ncbi Distribution of calcium-activated neutral proteinase activity in quaking mouse brain: a subcellular study
    N L Banik
    Department of Neurology, Medical University of South Carolina, Charleston 29425
    Brain Res 435:57-62. 1987
    The distribution of calcium-activated neutral proteinase (CANP) activity was examined in the subcellular fractions of quaking and control mouse brain...
  31. doi The Rengen Grassland experiment: bryophytes biomass and element concentrations after 65 years of fertilizer application
    Michal Hejcman
    Department of Ecology, Czech University of Life Sciences, Kamýcká 1176, 165 21, Prague 6 Suchdol, Czech Republic
    Environ Monit Assess 166:653-62. 2010
    ..in 1941, consists of the following fertilizer treatments applied under a two cut management: control, Ca, CaN, CaNP, CaNP-KCl, and CaNP-K(2)SO(4)...
  32. ncbi Three new combinations from the Cryptococcus laurentii complex: Cryptococcus aureus, Cryptococcus carnescens and Cryptococcus peneaus
    Masako Takashima
    Japan Collection of Microorganisms, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama 351 0198, Japan
    Int J Syst Evol Microbiol 53:1187-94. 2003
    ..The type strain of C. laurentii (CBS 139T=ATCC 18803T=JCM 9066T=MUCL 30398T=NRRL Y-2536T) was in phylogenetic group I...
  33. ncbi Coupling occurs before breakdown during biotransformation of Acid Blue 62 by white rot fungi
    Sophie Vanhulle
    Microbiology Unit, Universite Catholique de Louvain, Croix du Sud 3 boîte 6, B 1348 Louvain la Neuve, Belgium
    Chemosphere 70:1097-107. 2008
    ..During the biotransformation of an anthraquinonic dye Acid Blue 62 (ABu62) using Pycnoporus sanguineus MUCL 41582 strain, it was previously demonstrated that the blue colour of the medium turned to red before complete dye ..
  34. ncbi Reclassification of the Cryptococcus humicola complex
    M Takashima
    Japan Collection of Microorganisms, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama
    Int J Syst Evol Microbiol 51:2199-210. 2001
    ..Five novel species are proposed: Cryptococcus daszewskae sp. nov. (type strain CBS 5123T = JCM 11166T = MUCL 30649T), Cryptococcus fragicola sp. nov. (type strain JCM 1530TT = CBS 88981), Cryptococcus longus sp. nov...
  35. doi Effect of single nucleotide polymorphisms of CAPN1 and CAST genes on meat traits in Nellore beef cattle (Bos indicus) and in their crosses with Bos taurus
    R A Curi
    Departamento de Melhoramento e Nutrição Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade Estadual Paulista, Botucatu, SP 18618 000, Brazil
    Anim Genet 40:456-62. 2009
    ..of this work were to study the segregation of single nucleotide polymorphisms of the calpain 1, large subunit (CAPN1) and calpastatin (CAST) genes in Nellore (Bos indicus) and Nellore xBos taurus beef cattle, as well as to evaluate ..
  36. ncbi Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease
    A Hata
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    J Biol Chem 264:6404-11. 1989
    Calcium-dependent protease (CANP, Calpain) is an intracellular protease involved in essential cellular functions mediated by calcium...
  37. doi Synthesis of N-alkyl-beta-D-glucosylamines and their antimicrobial activity against Fusarium proliferatum, Salmonella typhimurium, and Listeria innocua
    T Muhizi
    UMR 5103 US2B, Unité des Sciences du Bois et des Biopolymères, Universite Bordeaux 1, INRA, CNRS, Talence, France
    J Agric Food Chem 57:11092-9. 2009
    ..were evaluated for both antifungal and antibacterial activity against Fusarium proliferatum (INRA, MUCL 1807.7), Listeria innocua (ISTAB, Université Bordeaux 1), and Salmonella typhimurium (Institut Pasteur 5858)...
  38. doi Impact of multispores in vitro subcultivation of Glomus sp. MUCL 43194 (DAOM 197198) on vegetative compatibility and genetic diversity detected by AFLP
    Antonio Cárdenas-Flores
    Unite de Microbiologie, Universite Catholique de Louvain, 1348 Louvain la Neuve, Belgium
    Mycorrhiza 20:415-25. 2010
    ..multispores clonal lineages, issued from the same ancestor culture of the arbuscular mycorrhizal fungal strain MUCL 43194 and subcultured several generations in different locations, was assessed...
  39. pmc Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets
    Shafi M Kuchay
    Department of Pharmacology, UIC Cancer Center, University of Illinois at Chicago, 909 South Wolcott Avenue, Room 5097, Chicago, IL 60612 3725, USA
    Mol Cell Biol 27:6038-52. 2007
    ..Here, we report that calpain-1 null (Capn1-/-) platelets accumulate protein tyrosine phosphatase 1B (PTP1B), which correlates with enhanced tyrosine ..
  40. doi Effects of dimethyl sulphoxide and dexamethasone on mRNA expression of myogenesis- and muscle proteolytic system-related genes in mouse myoblastic C2C12 cells
    Masuhiro Nishimura
    Otsuka Pharmaceutical Factory, Inc, Naruto, Tokushima 772 8601, Japan
    J Biochem 144:717-24. 2008
    ..Myogenin (Myog), Atrogin1, forkhead box O1 (Foxo1) and Capn1 mRNA levels increased in C2C12 cells differentiating from myoblasts to myotubes, whereas Myf5 mRNA levels ..
  41. ncbi Identification and molecular characterization of the rainbow trout calpains (Capn1 and Capn2): their expression in muscle wasting during starvation
    Mohamed Salem
    Division of Animal and Veterinary Sciences, West Virginia University, Morgantown, WV 26506 6108, USA
    Comp Biochem Physiol B Biochem Mol Biol 140:63-71. 2005
    ..The cDNA sequence for Capn1 encodes a protein of 704 amino acids with a calculated molecular mass of 79.9 kDa...
  42. ncbi Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies
    Thies Lindenlaub
    , Josef Schneider Strasse 11, 97080, , Germany
    Acta Neuropathol 105:593-602. 2003
    ..VANP), chronic inflammatory demyelinating neuropathy (CIDP), non-inflammatory chronic axonal neuropathy (CANP), and 3 controls. Overall cytokine immunoreactivity was highest in VANP, less strong in CIDP and lowest in CANP...
  43. ncbi Functional receptors for atrial natriuretic peptide in the rat mammary gland during lactation
    K Cvek
    Department of Animal Physiology, Swedish University of Agricultural Sciences, Uppsala
    Endocrinology 139:2615-21. 1998
    ..C-type natriuretic peptide and cANP(4-23) revealed limited competition with radiolabeled ANP only during early lactation, indicating a more ..
  44. ncbi Characterization of a Williopsis saturnus var. mrakii high molecular weight secreted killer toxin with broad-spectrum antimicrobial activity
    Cyril Guyard
    Département de Microbiologie des Ecosystèmes, IFR17, Institut Pasteur de Lille, 1 rue Calmette, BP 245, 59019 Lille, France
    J Antimicrob Chemother 49:961-71. 2002
    Williopsis saturnus var. mrakii MUCL 41968 secretes a killer toxin (WmKT), which is active against a wide range of pathogens. From the W. saturnus var...
  45. ncbi Identification and characterization of two novel calpain large subunit genes
    T N Dear
    Department of Developmental Immunology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Gene 274:245-52. 2001
    ..b>CAPN1 and CAPN2, the most well characterized calpains, consist of a large (80 kDa) and a small (30 kDa) subunit...
  46. ncbi CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6
    T N Dear
    Max Planck Institute for Immunobiology, Stuebeweg 51, Freiburg, D 79108, Germany
    Genomics 59:243-7. 1999
    ..Phylogenetic analysis suggests that, in mammals, the predicted CAPN11 protein is most closely related to CAPN1 and CAPN2...
  47. doi Ogataea cecidiorum sp. nov., a methanol-assimilating yeast isolated from galls on willow leaves
    Anna M Glushakova
    Faculty of Soil Science, Lomonosov Moscow State University, Leninskie Gory 1, Moscow, Russia 119991
    Antonie Van Leeuwenhoek 98:93-101. 2010
    ..describe it as Ogataea cecidiorum and designate type culture KBP Y-3846 (= CBS 11522(T) = VKM Y-2982(T) = VKPM Y-3482(T) = MUCL 52544(T) = NCAIM Y.01965(T)) as the type strain. The new species was registered in MycoBank under MB 515233.
  48. doi Association of CAPN1 316, CAPN1 4751 and TG5 markers with bovine meat quality traits in Mexico
    C A Bonilla
    Laboratorio de Ciencia de la Carne, Secretaría de Producción Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico
    Genet Mol Res 9:2395-405. 2010
    We examined allele and genotype frequencies for the molecular markers CAPN1 316, CAPN1 4751 and TG5, and determined whether they are associated with beef quality traits in Mexican cattle...
  49. doi Characterizing bone tunnel placement in medial ulnar collateral ligament reconstruction using patient-specific 3-dimensional computed tomography modeling
    Ian R Byram
    Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Sports Med 41:894-902. 2013
    Medial ulnar collateral ligament (MUCL) reconstruction is successful in restoring valgus elbow stability, but variability in bone tunnel characteristics exists among surgical techniques.
  50. ncbi Assessment of single nucleotide polymorphisms in genes residing on chromosomes 14 and 29 for association with carcass composition traits in Bos indicus cattle
    E Casas
    ARS, USDA, U S Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 83:13-9. 2005
    ..diacylglycerol O-acyltransferase 1 (DGAT1), thyroglobulin (TG), and micromolar calcium-activated neutral protease (CAPN1) genes with carcass composition and meat quality traits in Bos indicus cattle...
  51. pmc The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration
    Vishnu V Undyala
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    J Cell Sci 121:3581-8. 2008
    ..1 (mu-calpain) and calpain 2 (m-calpain), are heterodimers consisting of large catalytic subunits encoded by the Capn1 and Capn2 genes, respectively, and the small regulatory subunit encoded by Capn4...
  52. ncbi Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors
    Maria E Sabbatini
    Catedra de Fisiopatologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junín 956 piso 5, 1113 Buenos Aires, Argentina
    Am J Physiol Gastrointest Liver Physiol 285:G929-37. 2003
    ..The selective natriuretic peptide receptor-C (NPR-C) receptor agonist cANP-(4-23) mimicked ANF response in a dose-dependent fashion...
  53. doi The effects of Capn1 gene inactivation on skeletal muscle growth, development, and atrophy, and the compensatory role of other proteolytic systems
    C M Kemp
    USDA, ARS, U S Meat Animal Research Center, Clay Center, NE 68933, USA
    J Anim Sci 91:3155-67. 2013
    ..Collectively, these data suggest that there are opportunities to target the calpain system to promote the growth and/or restoration of skeletal muscle mass. ..
  54. doi Identification and association of polymorphisms in CAPN1 and CAPN3 candidate genes related to performance and meat quality traits in chickens
    A M Felício
    Departamento de Zootecnia, Escola Superior de Agricultura Luiz de Queiroz, Universidade de Sao Paulo, Piracicaba, SP, Brasil
    Genet Mol Res 12:472-82. 2013
    ..The calpain 1 (CAPN1) gene is related to the tenderness process of meat post- mortem, and the calpain 3 (CAPN3) gene plays an important ..
  55. doi Metschnikowia cubensis sp. nov., a yeast species isolated from flowers in Cuba
    Abel Fidalgo-Jiménez
    Instituto de Ecologia y Sistematica, Carretera de Varona, Boyeros, Ciudad de La Habana, Cuba
    Int J Syst Evol Microbiol 58:2955-61. 2008
    ..We propose the name Metschnikowia cubensis sp. nov. and designate MUCL 45753(T) (=CRGF 279(T) =CBS 10832(T), h(+)) as the type strain and MUCL 45751 (=CRGF 278 =CBS 10833, h(-)) as the ..
  56. pmc HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity
    Giovanni Passiatore
    Department of Neuroscience and Center for Neurovirology, Temple University School of Medicine, 1900 North 12th Street, Philadelphia, Pennsylvania 19122, USA
    Biochim Biophys Acta 1793:378-87. 2009
    ..Moreover, cleavage of Tat101 by calpain 1 increased neurotoxic effect of this viral protein and presence of the calpain inhibitor protected neuronal cells from Tat-mediated toxicity...
  57. doi Association of polymorphisms at DGAT1, leptin, SCD1, CAPN1 and CAST genes with color, marbling and water holding capacity in meat from beef cattle populations in Sweden
    Xin Li
    Swedish University of Agricultural Sciences, Uppsala BioCenter, Department of Food Science, Box 7051, Uppsala SE 750 07, Sweden
    Meat Sci 94:153-8. 2013
    ..878) and μ-calpain gene (CAPN1:c.947) were associated with variation in meat color traits after 6days of exposure to air...
  58. ncbi Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity
    Ying Wang
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 103:439-55. 2007
    ..Taken together, our data suggest calpain activation of CDK5, a pathway activated in HIV-infected individuals, can mediate neuronal damage and death in a model of HIV-induced neurotoxicity...
  59. doi Leucosporidium drummii sp. nov., a member of the Microbotryomycetes isolated from soil
    A M Yurkov
    Geobotanik, Fakultät für Biologie und Biotechnologie, Ruhr Universitat Bochum, Bochum, Germany
    Int J Syst Evol Microbiol 62:728-34. 2012
    ..nov., is proposed to accommodate the two strains, with SEG-3-2-AY220(T) (=CBS 11562(T)=MUCL 52878(T)) as the type strain...
  60. doi Genetic variants affecting meat and milk production traits appear to have effects on reproduction traits in cattle
    E Collis
    Cooperative Research Centre for Beef Genetic Technologies, Armidale, NSW, Australia
    Anim Genet 43:442-6. 2012
    Polymorphisms located in the genes ABCG2, DGAT1, LEP, PRLR, RORC, CAPN1 and CAST previously have been associated with milk or meat production traits...
  61. ncbi Calcium-activated neutral protease inhibitor from rabbit erythrocytes lacks the N-terminal region of the liver inhibitor but retains three inhibitory units
    S Imajoh
    Biochem Biophys Res Commun 146:630-7. 1987
    Endogenous inhibitors for calcium-activated neutral protease (CANP) were purified from rabbit erythrocytes and liver...
  62. ncbi A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13
    M Sawicki
    Department of Surgery Molecular Biology Core Unit, West Los Angeles Veterans Administration Medical Center, California 90073, USA
    Genomics 42:405-12. 1997
    ..Transcripts that map to the MEN1 interval PYGM-D11S449 include SGC35223, IB1256, AA147620, ZFM1, FAU, and CAPN1. The latter 3 known genes have already been excluded as candidate MEN1 genes...
  63. ncbi Possible involvement of differential splicing in regulation of the activity of Arabidopsis ANP1 that is related to mitogen-activated protein kinase kinase kinases (MAPKKKs)
    R Nishihama
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Plant J 12:39-48. 1997
    Three types of Arabidopsis cDNA (cANP1, cANP2 and cANP3) have been isolated that encode putative protein kinases, designated ANP1, ANP2 and ANP3...
  64. pmc Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases
    Ronald L Mellgren
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA
    Biochim Biophys Acta 1793:1886-93. 2009
    ..Utilizing isozyme-selective siRNAs to decrease expression of Capn1 or Capn2, catalytic subunits of mu- and m-calpains, respectively, in a mouse embryonic fibroblast cell line, we ..
  65. ncbi Immuno-crossreactivity of an anti-Pichia anomala killer toxin monoclonal antibody with a Williopsis saturnus var. mrakii killer toxin
    C Guyard
    , Institut Pasteur de Lille, France
    Med Mycol 39:395-400. 2001
    ..mrakii MUCL 41968 which inhibits the growth of a PaKT-sensitive P. anomala strain MUCL 41969...
  66. doi New single nucleotide polymorphisms in the mu-calpain gene in Spanish maternal beef breeds
    C Aviles
    MERAGEM Research Group Department of Genetics, Faculty of Veterinary Science, University of Cordoba, Cordoba, Spain
    Anim Biotechnol 20:161-4. 2009
    ..play an important role in the postmortem tenderization process of meat and several SNP in the mu-calpain gene (CAPN1) have been reported to be associated with tenderness in beef cattle...
  67. pmc Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis
    D C Shields
    Department of Neurology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 95:5768-72. 1998
    ..These findings suggest that increased levels of calpain in activated glial and inflammatory cells in EAE may contribute to myelin destruction in demyelinating diseases such as MS...
  68. ncbi N terminus of calpain 1 is a mitochondrial targeting sequence
    Ramakrishna Badugu
    Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington 40536 0509, USA
    J Biol Chem 283:3409-17. 2008
    ....
  69. doi Co-entrapment of Trichoderma harzianum and Glomus sp. within alginate beads: impact on the arbuscular mycorrhizal fungi life cycle
    N De Jaeger
    Universite Catholique de Louvain UCL, Earth and Life Institute, Mycology, Louvain la Neuve, Belgium
    J Appl Microbiol 111:125-35. 2011
    This study was performed to explore the compatibility and applicability of plant beneficial micro-organisms (i.e. Trichoderma harzianum MUCL 29707 and Glomus sp. MUCL 41833) co-entrapped in alginate beads.
  70. doi Atrial natriuretic factor intracellular signaling in the rat submandibular gland
    Maria S Ventimiglia
    Cátedras de Fisiopatología, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires Junin 956 Piso 5 1113AAD Buenos Aires, Argentina
    Regul Pept 150:43-9. 2008
    ..Dose-response curves to methacholine (MC) and norepinephrine (NE) were performed in the presence of cANP (4-23 amide) (selective NPR-C agonist) and ANF...
  71. pmc Calpain-1 cleaves Rad21 to promote sister chromatid separation
    Anil K Panigrahi
    Department of Pediatric Hematology Oncology, Baylor College of Medicine, 1102 Bates Avenue, Suite 1220, Houston, TX 77030
    Mol Cell Biol 31:4335-47. 2011
    ..Collectively, our work reveals a novel function of calpain-1 and describes an additional pathway for sister chromatid separation in humans...
  72. doi Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis
    Maria Klaude
    Department of Anaesthesiology and Intensive Care, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
    Clin Sci (Lond) 122:133-42. 2012
    ..In conclusion, the dramatic muscle wasting seen in critically ill patients with sepsis is due to increased protein degradation. This is facilitated by increased activities of both the proteasome and lysosomal proteolytic systems...
  73. ncbi Protease activity in brain, nerve, and muscle of hens given neuropathy-inducing organophosphates and a calcium channel blocker
    H A El-Fawal
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg 24061
    Toxicol Appl Pharmacol 103:133-42. 1990
    Activity of calcium-activated neutral protease (CANP or calpain), an enzyme responsible for degradation of axonal and muscle cytoskeletal elements, was determined in brain, sciatic nerve, and gastrocnemius muscle of hens given tri-ortho-..
  74. doi C-type natriuretic peptide receptor expression in pancreatic alpha cells
    Matthew D Burgess
    Surgery and Research and Development Services, James A Haley VA Hospital, Research Service 151, 13000 Bruce B Downs Boulevard, Tampa, FL 33612 4745, USA
    Histochem Cell Biol 132:95-103. 2009
    ..basal [7.3 fmol/min]; P < 0.001). This response was mimicked by cANP(4-23), a selective agonist of NPR-C...
  75. doi The endogenous modulators of Ca2+-Mg2+-dependent ATPase in children with chronic kidney disease (CKD)
    Dorota Polak-Jonkisz
    Department of Pediatric Nephrology, Wroclaw Medical University, Poland
    Nephrol Dial Transplant 25:438-44. 2010
    ..The aim of our study was to evaluate the activity of Ca(2+)-Mg(2+)-dependent ATPase (PMCA), calmodulin and calpain-calpastatin (CANP-CAST) system in erythrocytes of CKD children treated conservatively in the stages II-IV.
  76. doi A newly classified vertebrate calpain protease, directly ancestral to CAPN1 and 2, episodically evolved a restricted physiological function in placental mammals
    Daniel J Macqueen
    Physiological and Evolutionary Genomics Laboratory, School of Biology, Scottish Oceans Institute, University of St Andrews, St Andrews, Fife, United Kingdom
    Mol Biol Evol 27:1886-902. 2010
    The most studied members of the calpain protease superfamily are CAPN1 and 2, which are conserved across vertebrates. Another similar family member called mu/m-CAPN has been identified in birds alone...
  77. ncbi Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1
    Ian T Struewing
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Lexington, KY 40536, USA
    Exp Cell Res 313:3526-41. 2007
    ..Altogether, our findings pinpoint calpain-1 as a regulator of Frizzled-7 turnover at the plasma membrane and reveal a link between Frizzled-7 cleavage and its activity...
  78. doi Calpains: markers of tumor aggressiveness?
    Hélène Roumes
    Universite Bordeaux 1, Unité Protéolyse, Croissance et Développement Musculaire, INRA USC 2009, Talence, France
    Exp Cell Res 316:1587-99. 2010
    ....
  79. pmc Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells
    Liqun Jiang
    Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 3:e2231. 2008
    ..The consequences of engagement of calpain-1 with its substrates, however, in governing the age-associated proinflammatory status within the arterial wall, remains unknown...
  80. doi Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors
    Matthew A Jones
    Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Bioorg Med Chem 16:6911-23. 2008
    ..of N-heterocyclic dipeptide aldehydes 4-13 have been synthesised and evaluated as inhibitors of ovine calpain 1 (o-CAPN1) and ovine calpain 2 (o-CAPN2)...
  81. ncbi Association of SNPs on CAPN1 and CAST genes with tenderness in Nellore cattle
    L F B Pinto
    Grupo de Melhoramento Animal e Biotecnologia, Departamento de Ciencias Basicas, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de Sao Paulo, Pirassununga, SP, Brasil
    Genet Mol Res 9:1431-42. 2010
    ..An additive-by-additive epistatic interaction was observed between CAPN4751 and markers on the CAST gene. In conclusion, these markers should be considered for use in breeding programs...
  82. doi On an electrode modified by a supramolecular ruthenium mixed valence (Ru(II)/Ru(III)) diphosphine-porphyrin assembly
    Luis R Dinelli
    Fundacao Educacional de Barretos, CEP 14783 226, Barretos SP, Brazil
    Inorg Chem 48:4692-700. 2009
    ..Such tetraruthenated porphyrins form films of a mixed-valence species {TPyP[Ru(dppb)](4)(muCl(3))(2)}(2n)(4n2+) and {CoTPyP[Ru(dppb)](4)(muCl(3))(2)}(2n)(4n2+) on the electrode surface...
  83. doi Assessment of GH1, CAPN1 and CAST polymorphisms as markers of carcass and meat traits in Bos indicus and Bos taurus-Bos indicus cross beef cattle
    Rogério A Curi
    Departamento de Melhoramento e Nutrição Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade Estadual Paulista, Botucatu, SP 18618 000, Brazil
    Meat Sci 86:915-20. 2010
    The objective of this study was to investigate the effects of bovine GH1, CAPN1 and CAST gene polymorphisms on carcass and meat traits in Nellore and Nellore x Bos taurus beef cattle...
  84. doi Effects of flexor-pronator muscle loading on valgus stability of the elbow with an intact, stretched, and resected medial ulnar collateral ligament
    John H Udall
    Orthopaedic Biomechanics Laboratory, Long Beach VA Healthcare System, Mission Regional Medical Center, University of California, Irvine, CA 90822, USA
    J Shoulder Elbow Surg 18:773-8. 2009
    The medial ulnar collateral ligament (MUCL) is an important passive stabilizer to the valgus stresses that athletes experience during overhead throwing motion...
  85. doi Effects of genetic markers and implant strategy on longissimus and gluteus muscle tenderness of calf-fed steers and heifers
    S L Gruber
    Department of Animal Sciences, Colorado State University, Fort Collins, CO 80523 1171, USA
    J Anim Sci 89:1401-11. 2011
    ..The 3-marker GeneSTAR Tenderness panel [CAST (calpastatin), CAPN1 316 (µ-calpain), and CAPN1 4751 (µ-calpain)] was used to determine the GEN of each animal (reported as total ..
  86. doi Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer
    S Kulkarni
    Department of Molecular Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Oncogene 29:1339-50. 2010
    ..These data identify calpain as a new therapeutic target in HER2-positive breast cancer...
  87. doi Production and processing studies on calpain-system gene markers for tenderness in Brahman cattle: 1. Growth, efficiency, temperament, and carcass characteristics
    L M Cafe
    Australian Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, New South Wales 2351, Australia
    J Anim Sci 88:3047-58. 2010
    ..Genotypes for mu-calpain gene markers (CAPN1-4751 and CAPN1-316) were also determined and included in statistical analyses...
  88. doi Critical role of the calpain/calpastatin balance in acute allograft rejection
    Emmanuel Letavernier
    INSERM, UMR S 702, Paris, France
    Eur J Immunol 41:473-84. 2011
    ..This is the first study establishing that calpain inhibition delays allograft rejection by slowing down T-cell migration rather than proliferation...
  89. doi Zygosaccharomyces gambellarensis sp. nov., an ascosporogenous yeast isolated from an Italian 'passito' style wine
    Sandra Torriani
    Department of Biotechnology, University of Verona, Verona, Italy
    Int J Syst Evol Microbiol 61:3084-8. 2011
    ..The name Zygosaccharomyces gambellarensis is proposed for the novel species, with ZO03-5(T) (=CBS 12191(T)=MUCL 53393(T)) as the type strain.
  90. doi I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway
    Dae Seok Kim
    Cancer Cell and Molecular Biology Branch, National Cancer Center, Goyang, Gyeonggi do 410 769, Republic of Korea
    Biochem Biophys Res Commun 399:300-6. 2010
    ..This suggests that mu-calpain proteasome-dependent I-kappaBalpha polymer degradation may contribute to cancer progression through constitutive NF-kappaB activation...
  91. doi Investigation on CAST, CAPN1 and CAPN3 porcine gene polymorphisms and expression in relation to post-mortem calpain activity in muscle and meat quality
    G Gandolfi
    Department of Agri food Protection and Valorization, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
    Meat Sci 88:694-700. 2011
    This study aimed to detect variability in CAST, CAPN1 and CAPN3 porcine genes and to investigate the effect of CAST and CAPN1 polymorphisms on the activity of native and autolyzed μ-calpain and m-calpain, measured from 1 to 72 h post-..
  92. doi Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation
    Lei Ke
    Department of Radiation and Stress Cell Biology, University Institute for Drug Exploration GUIDE, University of Groningen, University Medical Center Groningen, The Netherlands
    J Mol Cell Cardiol 45:685-93. 2008
    ..Our results suggest that calpain inhibition may therefore represent a key target in combating AF-related structural and functional remodeling...
  93. ncbi Study on association of single nucleotide polymorphism of CAPN1 gene with muscle fibre and carcass traits in quality chicken populations
    Z R Zhang
    College of Animal Science and Technology, Sichuan Agriculture University, Ya an, Sichuan, PR China
    J Anim Breed Genet 125:258-64. 2008
    This study was aimed at investigating the effect of the calpain 1 (CAPN1) gene on carcass and meat quality traits in eight meat-type chicken populations, including five pure lines (developed from Chinese local breeds) and three cross-..
  94. pmc The calpain, caspase 12, caspase 3 cascade leading to apoptosis is altered in F508del-CFTR expressing cells
    Mathieu Kerbiriou
    INSERM, Brest, France
    PLoS ONE 4:e8436. 2009
    ..Here we show that the calcium-calpain-caspase-12-caspase-3 cascade is altered in F508del-CFTR expressing cells. We propose that this alteration is involved in the altered apoptosis triggering observed in CF...
  95. ncbi Hypoxia-induced cell death of HepG2 cells involves a necrotic cell death mediated by calpain
    Min Ju Kim
    Department of Biochemistry, College of Medicine, Hallym University, 1 Okchon Dong, Chuncheon, Gangwon do 200 702, Korea
    Apoptosis 12:707-18. 2007
    ....
  96. ncbi Calpain-dependent alpha-fodrin cleavage at the sarcolemma in muscle diseases
    Miwa Takamure
    Department of Neurology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Muscle Nerve 32:303-9. 2005
    ..These observations indicate that calpain is activated and reacts with alpha-fodrin as a substrate at the sarcolemma, and plays a key role in modulating sarcolemmal proteins to adapt to the specific conditions in each myopathy...
  97. ncbi NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain
    M T Corasaniti
    Faculty of Pharmacy, University of Reggio Calabria, Catanzaro, Italy
    Biochem Biophys Res Commun 229:299-304. 1996
    ..Altogether the data indicate that neuroblastoma cell death induced by NMDA and gp120 is of the necrotic type and this implicates calpain protease...
  98. ncbi Four genes for the calpain family locate on four distinct human chromosomes
    S Ohno
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Cytogenet Cell Genet 53:225-9. 1990
    ..The genes for calpain L1 (CAPN1, large subunit of calpain I), L2 (CAPN2, large subunit of calpain II), L3 (CAPN3, a protein related to the large ..
  99. ncbi Estimation of the cut-off value in cardiovascular autonomic nervous function tests: not-age-related criteria or the age-related 5th percentile
    R H Straub
    Department of Internal Medicine I, University Hospital, Regensburg, Germany
    J Diabetes Complications 11:145-50. 1997
    ..The cANP, pANP, and smNP were assessed using previously recommended standardized test procedures...
  100. ncbi The presenilin 2 loop domain interacts with the mu-calpain C-terminal region
    K Shinozaki
    Laboratory of Neurochemistry, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444, Japan
    Int J Mol Med 1:797-9. 1998
    ..In COS-1 cells, the interaction of PS2 with mu-calpain was confirmed by immunoprecipitation. These results suggested that PS2 and mu-calpain interact with each other, and might regulate each other's functions...
  101. ncbi Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria
    Brian M Polster
    The Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 280:6447-54. 2005
    ..Taken together, these results define a novel mechanism of AIF release involving calpain processing and identify a potential molecular checkpoint for cytoprotective interventions...

Research Grants70

  1. CALPAIN ACTIVATION OF T CELLS IN DEMYELINATING DISEASE
    Naren Banik; Fiscal Year: 2005
    ..Understanding the mechanisms involved in T cell activation and proliferation and the progression of demyelination may help to develop therapeutic strategies for the treatment of MS. ..
  2. NO synthase and NO-mediated signaling in plant defense
    Daniel Klessig; Fiscal Year: 2006
    ..recently obtained a highly purified tobacco NOS-like activity, cloned the corresponding gene from Arabidopsis (canP), and demonstrated that its encoded protein (a variant P subunit of glycine decarboxylase) has NO synthesizing ..
  3. CONJUNCTIVAL MUCINS--EXPRESSION AND SECRETION
    Marcia Jumblatt; Fiscal Year: 1999
    ..and mammary mucins have led to the identification and partial sequencing of eight distinct mucin species (MUCl-MUC8)...
  4. NEUROFILAMENTS: DEGRADATION TURNOVER & ROLE IN DISEASE
    WILLIAM SCHLAEPFER; Fiscal Year: 1991
    ..carried out to study the processes whereby neurofilaments (NF) are degraded by calcium-activated neutral protease (CANP), the nature of the NF products which are generated by this fragmentation, the fate of the NF degradative products ..
  5. CALPAIN ACTIVATION OF T CELLS IN DEMYELINATING DISEASE
    Naren Banik; Fiscal Year: 2009
    ..Understanding the mechanisms may help develop therapeutic strategies (e.g., calpain as a target) for treatment of MS. ..
  6. INTEGRINS: LINKING SENILE PLAQUES AND NEURITIC DYSTROPHY
    Adriana Ferreira; Fiscal Year: 2007
    ..A combination of techniques including Western blot analysis, in vitro protease assays, site-directed mutagenesis, and the suppression of protein expression by means of antisense oligonucleotides or siRNA will be used. ..
  7. Inflammation and Degeneration of Optic Nerve in EAE
    Naren L Banik; Fiscal Year: 2010
    ....
  8. Extra-nigral Neurodegeneration in Experimental Parkinson's Disease
    Naren L Banik; Fiscal Year: 2010
    ..Delineating a role for calpain in the progression of disease could potentially lead to new therapeutic targets since the most potent therapy, L-dopa, does not block the progression of Parkinson's disease. ..
  9. ROLE OF PROTEINASE IN SPINAL CORD INJURY
    Naren L Banik; Fiscal Year: 2010
    ....
  10. Attenuation of Axonal Damage and Neuronal Death in EAE
    Naren Banik; Fiscal Year: 2009
    ..abstract_text> ..
  11. Role of Phosphorylation in Regulating Calpain Activity
    DARREL GOLL; Fiscal Year: 2007
    ..The studies use mass spectrometry and Western analysis to monitor calpain phosphorylation and enzyme assays to monitor catalytic properties of the calpains. ..
  12. CALPAIN IN THE PATHOPHYSIOLOGY OF DEMYELINATING DISEASE
    Naren Banik; Fiscal Year: 2003
    ....
  13. Novel Tau-mediated Neurodegeneration Mechanisms
    ADRIANA B FERREIRA; Fiscal Year: 2010
    ..The data obtained could provide useful for the diagnosis, prevention, and eventually the treatment of AD and other tauopathies. ..
  14. Imaging Calpain/Bioenergetic Interactions in Neuronal Excitotoxicity
    BRIAN POLSTER; Fiscal Year: 2007
    ..This study will provide a strong foundation and powerful tools for the detailed investigation of cellular mechanisms underlying neurodegeneration. ..
  15. Regulation of anti- & pro-apoptotic functions of BAD
    BRIAN POLSTER; Fiscal Year: 2003
    ..Affinity-purification and yeast-two-hybrid screening will be used to search for novel BAD regulatory proteins that are differentially expressed during development. ..