CAND1

Summary

Gene Symbol: CAND1
Description: cullin associated and neddylation dissociated 1
Alias: TIP120, TIP120A, cullin-associated NEDD8-dissociated protein 1, TBP-interacting protein of 120 kDa A, p120 CAND1
Species: human
Products:     CAND1

Top Publications

  1. Hwang J, Min K, Tamura T, Yoon J. TIP120A associates with unneddylated cullin 1 and regulates its neddylation. FEBS Lett. 2003;541:102-8 pubmed
    ..We recently identified TIP120A as a cullin-interacting protein and found that TIP120A functions as a negative regulator of a ubiquitin ligase by ..
  2. Choo Y, Boh B, Lou J, Eng J, Leck Y, Anders B, et al. Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity. Mol Biol Cell. 2011;22:4706-15 pubmed publisher
    ..The deneddylating activity of CSN would subsequently promote its own dissociation to allow progression through the CRL activation cycle. ..
  3. Min K, Kwon M, Park H, Park Y, Yoon S, Yoon J. CAND1 enhances deneddylation of CUL1 by COP9 signalosome. Biochem Biophys Res Commun. 2005;334:867-74 pubmed
    ..Recent reports have suggested that CAND1, which specifically binds to unmodified CUL1 but not to neddylated one, is required for the in vivo function of ..
  4. Chew E, Hagen T. Substrate-mediated regulation of cullin neddylation. J Biol Chem. 2007;282:17032-40 pubmed
    ..neddylation by adaptor proteins and substrate recognition subunits in cells was found to be independent of both CAND1 and the COP9 signalosome, two negative regulators of cullin Nedd8 modification...
  5. Feng S, Shen Y, Sullivan J, Rubio V, Xiong Y, Sun T, et al. Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. Plant Cell. 2004;16:1870-82 pubmed
    ..Here, we report the identification of an Arabidopsis thaliana counterpart of human CAND1 (cullin-associated and neddylation-dissociated) and demonstrate that it can preferentially interact with ..
  6. Lo S, Hannink M. CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol. 2006;26:1235-44 pubmed
    ..Association of Keap1 with Cul3 was decreased by ectopic expression of CAND1 and was increased by small interfering RNA (siRNA)-mediated knockdown of CAND1...
  7. Min K, Hwang J, Lee J, Park Y, Tamura T, Yoon J. TIP120A associates with cullins and modulates ubiquitin ligase activity. J Biol Chem. 2003;278:15905-10 pubmed
    ..cullin-containing E3 ubiquitin ligases we immunopurified CUL4B-containing complex from HeLa cells and identified TIP120A as an associated protein by mass spectrometry...
  8. Oshikawa K, Matsumoto M, Yada M, Kamura T, Hatakeyama S, Nakayama K. Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. Biochem Biophys Res Commun. 2003;303:1209-16 pubmed
    ..resulted in the identification of a novel Cul1-binding protein: TATA-binding protein-interacting protein 120A (TIP120A, also called CAND1)...
  9. Liu J, Furukawa M, Matsumoto T, Xiong Y. NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell. 2002;10:1511-8 pubmed
    ..We show here that p120(CAND1) selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation...

More Information

Publications70

  1. Zheng J, Yang X, Harrell J, Ryzhikov S, Shim E, Lykke Andersen K, et al. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol Cell. 2002;10:1519-26 pubmed
    ..We report the isolation of a CUL1 binding protein, p120(CAND1). We found the majority of CUL1 is in a complex with CAND1 and ROC1 independent of SKP1 and F box protein SKP2...
  2. Goldenberg S, Cascio T, Shumway S, Garbutt K, Liu J, Xiong Y, et al. Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell. 2004;119:517-28 pubmed
    ..The SCF ubiquitin ligase complex regulates diverse cellular functions by ubiquitinating numerous protein substrates. Cand1, a 120 kDa HEAT repeat protein, forms a tight complex with the Cul1-Roc1 SCF catalytic core, inhibiting the ..
  3. Pierce N, Lee J, Liu X, Sweredoski M, Graham R, Larimore E, et al. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell. 2013;153:206-15 pubmed publisher
    ..that SCF(Fbxw7) is extraordinarily stable, but, in the Nedd8-deconjugated state, the cullin-binding protein Cand1 augments its dissociation by one-million-fold...
  4. Bornstein G, Ganoth D, Hershko A. Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate. Proc Natl Acad Sci U S A. 2006;103:11515-20 pubmed
    ..Neddylation is inhibited by the tight binding of cullins to CAND1 (cullin-associated and neddylation-dissociated 1) protein, and Nedd8 is removed from cullins by specific ..
  5. Bosu D, Feng H, Min K, Kim Y, Wallenfang M, Kipreos E. C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues. Dev Biol. 2010;346:113-26 pubmed publisher
    ..b>CAND1 is a biochemical inhibitor of CRLs, yet has been shown to promote CRL activity in plant and mammalian cells...
  6. Duda D, Borg L, Scott D, Hunt H, Hammel M, Schulman B. Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell. 2008;134:995-1006 pubmed publisher
    ..C-terminal domain (ctd) lysine stimulates CRL ubiquitination activity and prevents binding of the inhibitor CAND1. Here we report striking conformational rearrangements in the crystal structure of NEDD8~Cul5(ctd)-Rbx1 and SAXS ..
  7. Nakashima K, Takeuchi S, Iwama S, Kiyota A, Yasuda Y, Iwata N, et al. Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells. Endocr J. 2018;65:325-334 pubmed publisher
    ..S-transferase (GST)-pulldown assays and proteomic analyses, cullin-associated NEDD8-dissociated protein 1 (CAND1) was identified as a rabphilin-3A-binding protein in the posterior pituitary...
  8. Tanaka T, Nakatani T, Kamitani T. Negative regulation of NEDD8 conjugation pathway by novel molecules and agents for anticancer therapy. Curr Pharm Des. 2013;19:4131-9 pubmed
    ..g. COP9 signalosome, CAND1, inactive mutant of Ubc12 and NUB1/NUB1L) and clarifies possible strategies for targeting the NEDD8 cascade in ..
  9. Adhvaryu K, Gessaman J, Honda S, Lewis Z, Grisafi P, Selker E. The cullin-4 complex DCDC does not require E3 ubiquitin ligase elements to control heterochromatin in Neurospora crassa. Eukaryot Cell. 2015;14:25-8 pubmed publisher
    ..RING domain protein RBX1 and a segment of the CUL4 C terminus that normally interacts with RBX1, the E2 ligase, CAND1, and CSN are dispensable for DNA methylation and heterochromatin formation by DCDC...
  10. Ndila C, Uyoga S, Macharia A, Nyutu G, Peshu N, Ojal J, et al. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. Lancet Haematol. 2018;5:e333-e345 pubmed publisher
    ..FREM3, INPP4B, G6PD, HBA (both HBA1 and HBA2), HBB, IL10, LPHN2 (also known as ADGRL2), LOC727982, RPS6KL1, CAND1, and GNAS...
  11. Saito N, Sakakibara K, Sato T, Friedman J, Kufe D, Vonhoff D, et al. CBS9106-induced CRM1 degradation is mediated by cullin ring ligase activity and the neddylation pathway. Mol Cancer Ther. 2014;13:3013-23 pubmed publisher
    ..Knockdown of CSN5 or CAND1 also partially inhibited CBS9106-induced CRM1 degradation...
  12. von Deimling M, Häsler R, Steinbach V, Holterhus P, von Spiczak S, Stephani U, et al. Gene expression analysis in untreated absence epilepsy demonstrates an inconsistent pattern. Epilepsy Res. 2017;132:84-90 pubmed publisher
    ..genes with a consistent, but non-significant pattern of up- or down-regulation across all groups (ATP1B3, CAND1, PRPF6, TRIM8)...
  13. Gummlich L, Kähne T, Naumann M, Kilic E, Jung K, Dubiel W. New Insights Into the Mechanism of COP9 Signalosome-Cullin-RING Ubiquitin-Ligase Pathway Deregulation in Urological Cancers. Int Rev Cell Mol Biol. 2016;323:181-229 pubmed publisher
    ..components in RCC patient samples and four RCC cell lines revealed an interesting deregulated p27(Kip1)-Skp2-CAND1 axis and two p27(Kip1) point mutations in 786-O cells; p27(Kip1)V109G and p27(Kip1)I119T...
  14. Kamburov A, Lawrence M, Polak P, Leshchiner I, Lage K, Golub T, et al. Comprehensive assessment of cancer missense mutation clustering in protein structures. Proc Natl Acad Sci U S A. 2015;112:E5486-95 pubmed publisher
    ..interaction interfaces revealed enrichment of mutations in the interfaces between FBXW7-CCNE1, HRAS-RASA1, CUL4B-CAND1, OGT-HCFC1, PPP2R1A-PPP2R5C/PPP2R2A, DICER1-Mg2+, MAX-DNA, SRSF2-RNA, and others...
  15. Niemöller C, Renz N, Bleul S, Blagitko Dorfs N, Greil C, Yoshida K, et al. Single cell genotyping of exome sequencing-identified mutations to characterize the clonal composition and evolution of inv(16) AML in a CBL mutated clonal hematopoiesis. Leuk Res. 2016;47:41-6 pubmed publisher
    ..on the genetic information from the bulk specimen and analyses of individual bone marrow cells for mutations in CAND1, PTPRT, and DOCK6...
  16. Zhang S, Kou Y, Hu C, Han Y. MicroRNA profiling in the dentate gyrus in epileptic rats: The role of miR-187-3p. Medicine (Baltimore). 2017;96:e6744 pubmed publisher
    ..In addition, 7 overlapping target genes of rno-miR-187-3p were identified, including NFS1, PAQR4, CAND1, DCLK1, PRKAR2A, AKAP3, and KCNK10...
  17. Liu X, Reitsma J, Mamrosh J, Zhang Y, Straube R, Deshaies R. Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. Mol Cell. 2018;69:773-786.e6 pubmed publisher
    ..interplay of substrate binding, reversible Nedd8 conjugation on Cul1, and the F-box protein (FBP) exchange factors Cand1 and Cand2...
  18. Rulina A, Mittler F, Obeïd P, Gerbaud S, Guyon L, Sulpice E, et al. Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity. Cell Death Dis. 2016;7:e2505 pubmed publisher
    ..blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL regulator Cand1. We analyzed cell signaling to understand how varying degrees of CRL inhibition translated to distinct cell fates...
  19. Wang Y, Jia N, Xu C, Zhao L, Zhao Y, Wang X, et al. Selecting key genes associated with osteosarcoma based on a differential expression network. Genet Mol Res. 2015;14:17708-17 pubmed publisher
    ..Six hub genes (APP, UBC, CAND1, RPA, YWHAG, and NEDD8) were discovered; of these, two genes (UBC and RPA) were also found to be disease genes...
  20. Hu J, McCall C, Ohta T, Xiong Y. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol. 2004;6:1003-9 pubmed
    ..the DDB1-CUL4A association is negatively regulated by the cullin-associated and neddylation-dissociated protein, CAND1. Recombinant DDB1 and CDT1 bind directly to each other in vitro, and ectopically expressed DDB1 bridges CDT1 to ..
  21. Wang J, Reuschel E, Shackelford J, Jeang L, Shivers D, Diehl J, et al. HIV-1 Vif promotes the G?- to S-phase cell-cycle transition. Blood. 2011;117:1260-9 pubmed publisher
    ..These data suggest that Vif regulates early cell-cycle progression, with implications for infection and latency. ..
  22. Dubiel D, Gierisch M, Huang X, Dubiel W, Naumann M. CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis. Biochim Biophys Acta. 2013;1833:1078-84 pubmed publisher
    ..CRLs are regulated by the COP9 signalosome (CSN) and by Cullin-associated Nedd8-dissociated protein 1 (CAND1). The CSN is responsible for removal of Nedd8 from cullins inactivating CRLs...
  23. Kang M, Li Y, Zhao Y, He S, Shi J. miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer. Clin Transl Oncol. 2018;20:457-466 pubmed publisher
    ..with the para-carcinoma tissues, whereas its target mRNA of cullin-associated NEDD8-dissociated protein 1 (CAND1) was increased in NSCLC tissues...
  24. St Pourcain B, Cents R, Whitehouse A, Haworth C, Davis O, O Reilly P, et al. Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nat Commun. 2014;5:4831 pubmed publisher
    ..13, meta-GCTA h(2)(24-30-months) = 0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h(2)(24-months) = 0.20). ..
  25. Huang G, Stock C, Bommeljé C, Weeda V, Shah K, Bains S, et al. SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). J Biol Chem. 2014;289:34728-42 pubmed publisher
    ..We found that although SCCRO3 binds to CAND1, cullins, and ROC1, it does not efficiently bind to Ubc12, promote cullin neddylation, or conform to the reaction ..
  26. Tikhmyanova N, Tutton S, Martin K, Lu F, Kossenkov A, Paparoidamis N, et al. Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation. PLoS Pathog. 2017;13:e1006517 pubmed publisher
    ..Here, we identify the Cullin exchange factor CAND1 as a biochemical target of C60. We also identified CAND1 in an shRNA library screen for EBV lytic reactivation...
  27. Dubiel D, Ordemann J, Pratschke J, Dubiel W, Naumann M. CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis. Int J Biochem Cell Biol. 2015;66:95-100 pubmed publisher
    ..of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1...
  28. Yogosawa S, Kayukawa K, Kawata T, Makino Y, Inoue S, Okuda A, et al. Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A. Biochem Biophys Res Commun. 1999;266:123-8 pubmed
    TBP-interacting protein 120A (TIP120A) is a novel eukaryotic transcriptional regulator and has been suggested to be involved in the general regulation of transcription because of its ability to potentiate transcription of all classes of ..
  29. McCall C, Miliani de Marval P, Chastain P, Jackson S, He Y, Kotake Y, et al. Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol. 2008;28:5621-33 pubmed publisher
    ..Our studies identify a previously unknown function of VprBP in S-phase progression and suggest the possibility that HIV-1 Vpr may divert an ongoing chromosomal replication activity to facilitate viral replication. ..
  30. Yogosawa S, Makino Y, Yoshida T, Kishimoto T, Muramatsu M, Tamura T. Molecular cloning of a novel 120-kDa TBP-interacting protein. Biochem Biophys Res Commun. 1996;229:612-7 pubmed
    ..affinity-purification of proteins bound to TBP, we purified a 120-kD protein, termed TBP-interacting protein 120 (TIP120), from rat liver nuclear extracts...
  31. Menon S, Tsuge T, Dohmae N, Takio K, Wei N. Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. BMC Biochem. 2008;9:1 pubmed publisher
    ..Neddylation is shown to facilitate E3 complex assembly; while un-neddylated cullins are bound by CAND1 that prevents recruitment of the substrates...
  32. Potkin S, Guffanti G, Lakatos A, Turner J, Kruggel F, Fallon J, et al. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. PLoS ONE. 2009;4:e6501 pubmed publisher
    ..These candidates included EFNA5, CAND1, MAGI2, ARSB, and PRUNE2, genes involved in the regulation of protein degradation, apoptosis, neuronal loss and ..
  33. Schumacher F, Siew K, Zhang J, Johnson C, Wood N, Cleary S, et al. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. EMBO Mol Med. 2015;7:1285-306 pubmed publisher
    ..auto-ubiquitylates and loses interaction with two important Cullin regulators: the COP9-signalosome and CAND1. A novel knock-in mouse model of CUL3(WT) (/Δ403-459) closely recapitulates the human PHA2E phenotype...
  34. Jonason J, Gavrilova N, Wu M, Zhang H, Sun H. Regulation of SCF(SKP2) ubiquitin E3 ligase assembly and p27(KIP1) proteolysis by the PTEN pathway and cyclin D1. Cell Cycle. 2007;6:951-61 pubmed
    ..PI 3-kinase pathway prevents formation of the SCF(SKP2) complex, with a simultaneous increase in CUL1 binding to CAND1. CAND1-CUL1 binding is known to block the accessibility of CUL1 to SKP1 and (SKP2)...
  35. Straube R, Shah M, Flockerzi D, Wolf D. Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire. PLoS Comput Biol. 2017;13:e1005869 pubmed publisher
    ..different groups proposed that the exchange of substrate receptors is mediated by a protein exchange factor named Cand1. Here, we have performed mathematical modeling to provide a quantitative underpinning of this hypothesis...
  36. Liu Q, Zhou Y, Tang R, Wang X, Hu Q, Wang Y, et al. Increasing the Unneddylated Cullin1 Portion Rescues the csn Phenotypes by Stabilizing Adaptor Modules To Drive SCF Assembly. Mol Cell Biol. 2017;37: pubmed publisher
    ..based on the deneddylation activity of the COP9 signalosome (CSN) and global sequestration of cullins by CAND1. However, acceptance of this prediction was hampered by the results of recent studies, and the regulatory ..
  37. Yang Y, He S, Wang Q, Li F, Kwak M, Chen S, et al. Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016;62:507-19 pubmed publisher
    ..Our results identify UVRAG as a regulator of CRL4(DDB2)-mediated NER and suggest that its expression levels may influence melanoma predisposition. ..
  38. Ghosal G, Leung J, Nair B, Fong K, Chen J. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem. 2012;287:34225-33 pubmed publisher
    ..Thus, C1orf124 acts at multiple steps in TLS, stabilizes RAD18 and ubiquitinated PCNA at damage sites, and facilitates the switch from replicative to TLS polymerase to bypass DNA lesion. ..
  39. Kim A, Bommelje C, Lee B, Yonekawa Y, Choi L, Morris L, et al. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. J Biol Chem. 2008;283:33211-20 pubmed publisher
    ..that SCCRO (also known as DCUN1D1) binds to the components of the neddylation pathway (Cullin-ROC1, Ubc12, and CAND1) and augments but is not required for cullin neddylation in reactions using purified recombinant proteins...
  40. Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine G, et al. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. J Biol Chem. 2011;286:32355-65 pubmed publisher
    ..CRL activity is regulated by CAND1 (Cullin-associated Nedd8-dissociated protein 1), an inhibitor that promotes the dissociation of substrate receptor ..
  41. Keuss M, Thomas Y, Mcarthur R, Wood N, Knebel A, Kurz T. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci. 2016;129:1441-54 pubmed publisher
    ..We found that DCNLs form stable stoichiometric complexes with CAND1 and cullins that can only be neddylated in the presence of a substrate adaptor...
  42. Nemajerova A, Mena P, Fingerle Rowson G, Moll U, Petrenko O. Impaired DNA damage checkpoint response in MIF-deficient mice. EMBO J. 2007;26:987-97 pubmed
    ..Given that CSN plays a central role in the assembly of SCF complexes in vivo, regulation of Jab1/CSN5 by MIF is required to sustain optimal composition and function of the SCF complex. ..
  43. He X, Ding X, Wen D, Hou J, Ping J, He J. Exploration of the pathways and interaction network involved in bladder cancer cell line with knockdown of Opa interacting protein 5. Pathol Res Pract. 2017;213:1059-1066 pubmed publisher
    ..In the PPI network, CAND1 and MYC had the highest connectivity with DEGs...
  44. Yoshimura S, Kumeta M, Takeyasu K. Structural mechanism of nuclear transport mediated by importin β and flexible amphiphilic proteins. Structure. 2014;22:1699-710 pubmed
    ..These results show that conformational changes in the flexible amphiphilic motifs play a critical role in translocation through the NPC. ..
  45. You J, Pickart C. A HECT domain E3 enzyme assembles novel polyubiquitin chains. J Biol Chem. 2001;276:19871-8 pubmed
  46. Reitsma J, Liu X, Reichermeier K, Moradian A, Sweredoski M, Hess S, et al. Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. Cell. 2017;171:1326-1339.e14 pubmed publisher
    ..We show that Nedd8 conjugation and the SR exchange factor Cand1 have a profound effect on shaping the SCFome...
  47. Aoki T, Okada N, Wakamatsu T, Tamura T. TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3. Biochem Biophys Res Commun. 2002;296:1097-103 pubmed
    TBP-interacting protein 120 (TIP120) has been identified by TBP-mediated affinity screening. Classical TIP120, TIP120A, which functions as a transcriptional activator, is expressed ubiquitously whereas TIP120B is specifically expressed ..
  48. Lee J, Sweredoski M, Graham R, Kolawa N, Smith G, Hess S, et al. The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. Mol Cell Proteomics. 2011;10:M110.006460 pubmed publisher
    ..Cycles of Nedd8 conjugation and deconjugation acting in conjunction with the Cul1-sequestering factor Cand1 are thought to control dynamic cycles of SCF assembly and disassembly, which would enable a dynamic equilibrium ..
  49. Pisano A, Ceglia S, Palmieri C, Vecchio E, Fiume G, De Laurentiis A, et al. CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation. J Biol Chem. 2015;290:13958-71 pubmed publisher
    ..By characterizing CRL3(IBTK) as a novel ubiquitin ligase, this study provides new insights into regulatory mechanisms of cellular pathways, such as the Pdcd4-dependent translation of mRNAs. ..
  50. Bagchi R, Melnyk C, Christ G, Winkler M, Kirchsteiner K, Salehin M, et al. The Arabidopsis ALF4 protein is a regulator of SCF E3 ligases. EMBO J. 2018;37:255-268 pubmed publisher
    ..CRL activity is controlled by several proteins or protein complexes, including NEDD8, CAND1, and the CSN Recently, a mammalian protein called Glomulin (GLMN) was shown to inhibit CRLs by binding to the RING ..
  51. Chua Y, Boh B, Ponyeam W, Hagen T. Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo. PLoS ONE. 2011;6:e16071 pubmed publisher
    ..b>CAND1, which binds to cullins that are not conjugated with Nedd8 and not associated with substrate receptors, has been ..
  52. Latini P, Frontini M, Caputo M, Gregan J, Cipak L, Filippi S, et al. CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination. Cell Cycle. 2011;10:3719-30 pubmed publisher
    ..The deregulation of p53, in absence of either of the CS proteins, can potentially explain the early onset degeneration of tissues and organs observed in CS patients. ..
  53. Jabs V, Edlund K, König H, Grinberg M, Madjar K, Rahnenführer J, et al. Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer. PLoS ONE. 2017;12:e0187246 pubmed publisher
    ..are the chaperone CCT2, the core complex protein NUP107 and the ubiquitination and neddylation associated protein CAND1. In conclusion, in a comprehensive analysis we described a distinct set of highly correlating genes...
  54. Bommelje C, Weeda V, Huang G, Shah K, Bains S, Buss E, et al. Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization. Clin Cancer Res. 2014;20:372-81 pubmed publisher
    ..Our data suggest that SCCRO5 has oncogenic potential that requires its function as a component of the neddylation E3. Neddylation activity and nuclear localization of SCCRO5 are important for its in vivo function. ..
  55. Huang G, Towe C, Choi L, Yonekawa Y, Bommeljé C, Bains S, et al. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity. J Biol Chem. 2015;290:296-309 pubmed publisher
    ..The clustering of mutations in the UBA domain of SCCRO suggests that mutations may be a mechanism of oncogene activation in human cancers. ..
  56. Korzeniewski N, Hohenfellner M, Duensing S. CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer. Neoplasia. 2012;14:799-806 pubmed
    ..Here, we identify the CUL1-interacting protein cullin-associated and neddylation-dissociated 1 (CAND1) as a novel centrosomal protein with a role in centriole duplication control...
  57. Emberley E, Mosadeghi R, Deshaies R. Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. J Biol Chem. 2012;287:29679-89 pubmed publisher
    ..Upon consumption of substrate and subsequent deneddylation, CSN can remain stably bound to the CRL and hold it in low state of reduced activity. ..
  58. Murata T, Takayama K, Katayama S, Urano T, Horie Inoue K, Ikeda K, et al. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. Prostate Cancer Prostatic Dis. 2010;13:356-61 pubmed publisher
    ..we have determined that miR-148a reduces the expression of cullin-associated and neddylation-dissociated 1 (CAND1), a negative regulator of SKP1-Cullin1-F-box (SCF) ubiquitin ligases, by binding to the 3'-untranslated region of ..
  59. Zhang S, Huang J, Shi T, Hu F, Zhang L, Zhou P, et al. DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage. Oncotarget. 2016;7:58483-58491 pubmed publisher
    ..Through Co-immunoprecipitation experiments, we found that DCUN1D3 bound to CAND1. And DCUN1D3 knockdown synergized with CAND1 over-expression in arresting the S phase...
  60. Buonanno M, Langella E, Zambrano N, Succoio M, Sasso E, Alterio V, et al. Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements. ACS Chem Biol. 2017;12:1460-1465 pubmed publisher
    ..In a recent paper, we showed that CA IX interacts with cullin-associated NEDD8-dissociated protein 1 (CAND1), a nuclear protein involved in gene transcription and assembly of SCF ubiquitin ligase complexes...
  61. Gastaldello S, Callegari S, Coppotelli G, Hildebrand S, Song M, Masucci M. Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1. J Mol Cell Biol. 2012;4:242-51 pubmed publisher
    ..domain (CTD) of cullins, at a site involved in electrostatic interaction with helix-8 of the CRL regulator CAND1. Mutation of the solvent-exposed Asp86 and Asp90 of helix-2 to Arg does not affect the enzymatic activity of BPLF1 ..