CAMK4

Summary

Gene Symbol: CAMK4
Description: calcium/calmodulin-dependent protein kinase IV
Alias: CaMK IV, CaMK-GR, caMK, CAM kinase IV, CAM kinase- GR, brain Ca(2+)-calmodulin-dependent protein kinase type IV, brain Ca++-calmodulin-dependent protein kinase type IV, caM kinase-GR, calcium/calmodulin-dependent protein kinase type IV, calcium/calmodulin-dependent protein kinase type IV catalytic chain
Species: human

Top Publications

  1. pmc Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells
    Maddalena Illario
    Department of Molecular and Cellular Biology and Pathology, Federico II University of Naples, Italy
    Blood 111:723-31. 2008
  2. ncbi A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR
    T Chatila
    Department of Pediatrics, Washington University School of Medicine, St Louis Missouri 63110, USA
    J Biol Chem 271:21542-8. 1996
  3. ncbi Ca(2+)-dependent gene expression mediated by MEF2 transcription factors
    F Blaeser
    Department of Pediatrics, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 275:197-209. 2000
  4. ncbi An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory
    H Kang
    Howard Hughes Medical Institute, New Haven, CT 06511, USA
    Cell 106:771-83. 2001
  5. ncbi Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus
    Shannon M Lemrow
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:11664-71. 2004
  6. ncbi Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit
    M K Jang
    Center for Ligand and Transcription, Chonnam National University, Kwangju 500 757, Seoul 151 742, Korea
    J Biol Chem 276:20005-10. 2001
  7. ncbi Effect of neuronal nitric oxide synthase inhibition on CA2+/calmodulin kinase kinase and CA2+/calmodulin kinase IV activity during hypoxia in cortical nuclei of newborn piglets
    A B Zubrow
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA
    Neuroscience 125:937-45. 2004
  8. ncbi MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo
    O Heidenreich
    Institut fur Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 274:14434-43. 1999
  9. ncbi Effect of post-hypoxic MgSO(4) administration in utero on Ca(2+)-influx and Ca(2+)/calmodulin kinase IV activity in cortical neuronal nuclei
    Dev Maulik
    Department of Obstetrics and Gynecology, Winthrop University Hospital, 259 First Street, Mineola, NY 11501, USA
    Neurosci Lett 386:127-32. 2005
  10. doi Thyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway
    Beatriz Morte
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Madrid, Spain
    Endocrinology 151:810-20. 2010

Research Grants

  1. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2009
  2. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2010
  3. GENETIC ANALYSIS OF SIGNALING BY CARDIAC ENDOTHELIN-1
    Ralph Shohet; Fiscal Year: 2004
  4. IN VIVO CEREBRAL OXIDATIVE METABOLISM IN HYPOXIC NEWBORNS
    MARIA D DELIVORIA PAPADOPOULOS; Fiscal Year: 2010
  5. Estrogen and CaM Kinase IV in the Limbic System
    ROCHELLE COHEN; Fiscal Year: 2006
  6. BIOLOGY OF THE TESTIS
    ANTHONY MEANS; Fiscal Year: 2005
  7. Calmodulin Dependent Protein Kinase Kinase
    THOMAS SODERLING; Fiscal Year: 2005
  8. Calcium signaling in neuronal differentiation
    Lori Redmond; Fiscal Year: 2007
  9. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
  10. CaM Kinase Cascades in Endocrine Cells
    ANTHONY MEANS; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. pmc Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells
    Maddalena Illario
    Department of Molecular and Cellular Biology and Pathology, Federico II University of Naples, Italy
    Blood 111:723-31. 2008
    ..Although isolated Camk4-/- DCs are able to acquire the phenotype typical of mature cells and release normal amounts of cytokines in ..
  2. ncbi A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR
    T Chatila
    Department of Pediatrics, Washington University School of Medicine, St Louis Missouri 63110, USA
    J Biol Chem 271:21542-8. 1996
    ..This three-step requirement is unique among the multifunctional Ca2+/calmodulin-dependent kinases...
  3. ncbi Ca(2+)-dependent gene expression mediated by MEF2 transcription factors
    F Blaeser
    Department of Pediatrics, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 275:197-209. 2000
    ..These results identify MEF2 proteins as effectors of a pathway of gene induction in T lymphocytes which integrates diverse Ca(2+) activation signals and may be broadly operative in several tissues...
  4. ncbi An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory
    H Kang
    Howard Hughes Medical Institute, New Haven, CT 06511, USA
    Cell 106:771-83. 2001
    ..These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory...
  5. ncbi Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus
    Shannon M Lemrow
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:11664-71. 2004
    ..We propose that sequestration of CaMKK may be the molecular mechanism by which catalytically inactive mutants of CaMKIV exert their "dominant-negative" functions within the cell...
  6. ncbi Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit
    M K Jang
    Center for Ligand and Transcription, Chonnam National University, Kwangju 500 757, Seoul 151 742, Korea
    J Biol Chem 276:20005-10. 2001
    ..Consistent with these results, cotransfected CaMKIV dramatically stimulated the NFkappaB transactivation in mammalian cells. From these results, NFkappaB is suggested to be a novel downstream effector molecule of CaMKIV...
  7. ncbi Effect of neuronal nitric oxide synthase inhibition on CA2+/calmodulin kinase kinase and CA2+/calmodulin kinase IV activity during hypoxia in cortical nuclei of newborn piglets
    A B Zubrow
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA
    Neuroscience 125:937-45. 2004
    ..To test this hypothesis, CaM kinase kinase and CaM kinase IV activities were determined in normoxic, hypoxic, NNLA-treated hypoxic, and 7-NINA-treated hypoxic piglets...
  8. ncbi MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo
    O Heidenreich
    Institut fur Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 274:14434-43. 1999
    Several growth factor- and calcium-regulated kinases such as pp90(rsk) or CaM kinase IV can phosphorylate the transcription factor serum response factor (SRF) at serine 103 (Ser-103)...
  9. ncbi Effect of post-hypoxic MgSO(4) administration in utero on Ca(2+)-influx and Ca(2+)/calmodulin kinase IV activity in cortical neuronal nuclei
    Dev Maulik
    Department of Obstetrics and Gynecology, Winthrop University Hospital, 259 First Street, Mineola, NY 11501, USA
    Neurosci Lett 386:127-32. 2005
    Previously we have demonstrated that in utero hypoxia results in increased nuclear Ca(2+)-influx and increased CaM kinase IV activity in neuronal nuclei of the guinea pig fetus...
  10. doi Thyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway
    Beatriz Morte
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Madrid, Spain
    Endocrinology 151:810-20. 2010
    ..differentially expressed genes were related to each other centered on the Ca(2+) and calmodulin-activated kinase (Camk4) pathway...
  11. ncbi Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Asahikawa 078 8510, Japan
    J Biochem 127:965-70. 2000
    ..However, the specific activities of CaM-kinase kinase alpha and CaM-kinase II as to the activation of PKB were more than three orders of magnitude lower than that of 3-phosphoinositide-dependent protein kinase 1 (PDK1)...
  12. ncbi Subcellular distributions of rat CaM kinase phosphatase N and other members of the CaM kinase regulatory system
    Takako Kitani
    Department of Biochemistry, Asahikawa Medical College, Japan
    J Neurochem 86:77-85. 2003
    ..indicate that CaM kinase I, CaM kinase kinase beta, and CaM kinase phosphatase occur in the cytoplasm and that CaM kinase IV, CaM kinase kinase alpha (and CaM kinase kinase beta in some cell types and tissues), and CaM kinase ..
  13. ncbi Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice
    Takayuki Akimoto
    Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
    Am J Physiol Cell Physiol 287:C1311-9. 2004
    ..stimulation (2 h at 10 Hz) likewise increased PGC-1alpha mRNA expression in tibialis anterior muscles in both Camk4(-/-) and wild-type mice...
  14. doi Difference in physiogenomics between male and female infertility
    V Wiwanitkit
    Wiwanitkit House, Bangkhae, Bangkok, Thailand Hainan Medical College, Hainan, China
    Andrologia 40:158-60. 2008
    ..According to this work, there is only one identified physiogenomic relationship on chromosome 5 (CAMK4) for male but there are four identified physiogenomic relationships on chromosome 12 (CD9), chromosome 19 (BSG), ..
  15. doi Arsenic down-regulates the expression of Camk4, an important gene related to cerebellar LTD in mice
    Yanyan Wang
    Department of Occupational and Environmental of Health, Dalian Medical University, Liaoning, PR China
    Neurotoxicol Teratol 31:318-22. 2009
    ..group than controls and the down-regulated expression of Ca(2+)/calmodulin dependent protein kinase IV (Camk4), a very important regulator in the LTD pathway...
  16. ncbi Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription
    Lori Redmond
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 34:999-1010. 2002
    We report that CaM kinase IV and CREB play a critical role in mediating calcium-induced dendritic growth in cortical neurons...
  17. ncbi Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice
    T J Ribar
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 20:RC107. 2000
    ..To understand the physiological importance of CaMKIV, we disrupted the mouse Camk4 gene. The CaMKIV null mice displayed locomotor defects consistent with altered cerebellar function...
  18. ncbi Activation of Ca2+/calmodulin-dependent protein kinase I in cultured rat hippocampal neurons
    Akiyoshi Uezu
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto, Japan
    J Neurochem 82:585-93. 2002
    ..protein kinase (CaM) kinase I in the hippocampal neurons and compared them with that of CaM kinase IV. Increased activation of CaM kinase I occurred by stimulation with glutamate and depolarization in cultured ..
  19. ncbi CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV
    S Chawla
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 281:1505-9. 1998
    ..These results identify CBP as a signal-regulated transcriptional coactivator and define a regulatory role for nuclear calcium and cAMP in CBP-dependent gene expression...
  20. ncbi Functional proteins involved in regulation of intracellular Ca(2+) for drug development: role of calcium/calmodulin-dependent protein kinases in ischemic neuronal death
    Shigetoshi Yano
    Department of Neurosurgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Graduate School, Kumamoto
    J Pharmacol Sci 97:351-4. 2005
    ..Calcium/calmodulin (CaM)-dependent protein kinase kinase (CaM-KK) is an upstream kinase for CaM kinase IV (CaM-KIV) that was reported to prevent apoptosis through phosphorylation of CREB (cyclic AMP responsive ..
  21. ncbi Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene
    Z Sun
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 270:29507-14. 1995
    A 42-kilobase pair region of rat DNA containing the Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV) gene has been cloned and characterized...
  22. ncbi Cloning and sequencing of a gene encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV and its expression confined to the mature cerebellar granule cells
    H Sakagami
    Department of Anatomy, Tohoku University School of Medicine, Sendai, Japan
    Brain Res Mol Brain Res 19:215-8. 1993
    A cDNA encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV) was isolated and sequenced from a rat cerebellar cDNA library...
  23. ncbi Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex
    S C Pandey
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Pharmacol Exp Ther 296:857-68. 2001
    ..catalytic subunits of PKA, and on the protein expression of Ca(2+)/calmodulin-dependent protein kinase IV (CaM kinase IV) and calcineurin in the rat cortex were also investigated...
  24. ncbi A new locus for hereditary gingival fibromatosis (GINGF2) maps to 5q13-q22
    S Xiao
    University of Science and Technology of China, Hefei, People s Republic of China
    Genomics 74:180-5. 2001
    ..31 at D5S1721 (theta = 0.00). Haplotype analysis placed the critical region in the interval defined by D5S1491 and D5S1453. Within this region, calcium/calmodulin-dependent protein kinase IV (CAMK4) is a strong candidate.
  25. ncbi cDNA sequence and differential expression of the mouse Ca2+/calmodulin-dependent protein kinase IV gene
    D A Jones
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262
    FEBS Lett 289:105-9. 1991
    ..Of the tissues examined, expression of the CaM kinase IV gene is restricted to brain and testis, where transcripts are differentially expressed to produce a kinase in ..
  26. doi Chronic ethanol intake-induced changes in open-field behavior and calcium/calmodulin-dependent protein kinase IV expression in nucleus accumbens of rats: naloxone reversal
    Jing Li
    Department of Pathophysiology, Nanjing Medical University, Nanjing 210029, China
    Acta Pharmacol Sin 29:646-52. 2008
    ..ethanol intake on the locomotor activity and the levels of calcium/calmodulin-dependent protein kinase IV (CaM kinase IV) in the nucleus accumbens (NAc) of rats...
  27. pmc Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study
    Shad B Smith
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, North Carolina 27514, USA
    J Pain 12:T92-101. 2011
    ..Other genes were revealed as potential new genetic risk factors for TMD, including NR3C1, CAMK4, CHRM2, IFRD1, and GRK5...
  28. doi Functional heterogeneity of human effector CD8+ T cells
    Hiroshi Takata
    Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    Blood 119:1390-8. 2012
    ..These differences were explained by the specific up-regulation of CAMK4, SPRY2, and IL-7R in the CXCR1(-) subset and that of pro-apoptotic death-associated protein kinase 1 (DAPK1) in ..
  29. doi Genome-wide disease association study in chewing tobacco associated oral cancers
    Renu Bhatnagar
    Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Center, Thane Belapur, Rabale, Navi Mumbai 400 701, India
    Oral Oncol 48:831-5. 2012
    ..of Genes and Genome Pathway database, indicated SNP association with several genes including GRIK2, RASGRP3, CAMK4, SYK, RAPTOR, FHIT, DCC, active in signal transduction; MMP2, CNTNAP2, PTPRJ associated with tumor cell migration; ..
  30. doi Novel mutations in calcium/calmodulin-dependent protein kinase IV (CAMK4) gene in infertile men
    A Khattri
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Int J Androl 35:810-8. 2012
    Calcium/calmodulin-dependent protein kinase IV (CAMK4) is a multifunctional serine/threonine protein kinase, which plays an important role in the spermatogenesis by phosphorylating protamines...
  31. pmc Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus
    Tomohiro Koga
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 189:3490-6. 2012
    The activity of calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased in T cells from patients with systemic lupus erythematosus (SLE) and has been shown to reduce IL-2 production by promoting the effect of the ..
  32. pmc Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene
    C A Ohmstede
    Department of Cell Biology, Burroughs Wellcome Co, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 88:5784-8. 1991
    Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells (CaM kinase Gr) is a neuronal calmodulin-dependent protein kinase whose purification and partial cloning from rat brain has been described...
  33. ncbi Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation
    H Enslen
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    J Biol Chem 269:15520-7. 1994
    We have characterized Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV), expressed using the baculovirus/Sf9 cell system, to assess its potential role in Ca2+-dependent transcriptional regulation...
  34. ncbi The Ca2+/calmodulin-dependent kinase type IV is involved in the CD5-mediated signaling pathway in human T lymphocytes
    S I Gringhuis
    Division of Hematology, Department of Internal Medicine, University of Groningen, 9713 GZ Groningen, The Netherlands
    J Biol Chem 272:31809-20. 1997
    ..The expression of a dominant negative mutant of CaM kinase IV in T lymphocytes transfected with an IL-2 promoter-driven reporter construct completely abrogates the response ..
  35. pmc Brain tissue energy dependence of CaM kinase IV cascade activation during hypoxia in the cerebral cortex of newborn piglets
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s, Hospital for Children, Philadelphia, PA 19102, USA
    Neurosci Lett 491:113-7. 2011
    The present study aims to investigate the dependence of CaM kinase IV cascade activation during hypoxia and tests the hypothesis that hypoxia-induced tyrosine phosphorylation of CaM and CaM kinase IV, activation of CaM kinase IV and ..
  36. ncbi Molecular cloning of Ca2+/calmodulin-dependent protein kinase kinase beta
    T Kitani
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 122:243-50. 1997
    ..Western blot analysis revealed that CaM-kinase kinase beta significantly existed only in the brain. The enzyme was not significantly detected in the retina where CaM-kinase kinase alpha exists...
  37. pmc Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade
    H Enslen
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Proc Natl Acad Sci U S A 93:10803-8. 1996
    ..These results establish a new Ca2+-dependent mechanism for regulating MAP kinase pathways and resultant transcription...
  38. pmc Major signaling pathways in migrating neuroblasts
    Konstantin Khodosevich
    Department of Clinical Neurobiology, Interdisciplinary Center for Neurosciences Heidelberg, Germany
    Front Mol Neurosci 2:7. 2009
    ..Thus, knockdown of Calm1, Gria1 (GluA1) and Camk4 (calmodulin-signaling network), Hdac2 and Hsbp1 (Akt1-DNA transcription network), Vav3 and Ppm1a (growth factor ..
  39. pmc Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells
    David M Feliciano
    Department of Pharmacology and Toxicology, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 284:26466-81. 2009
    ..RA-induced repression of the CaMKIV signaling pathway may represent an early event in retinoid-dependent neuronal differentiation...
  40. pmc Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:18953-62. 2009
    ..Our study has provided strong evidence for CaMKIV as a molecular link between Group I mGluRs and FMRP in ACC neurons and may help us to elucidate the pathogenesis of fragile X syndrome...
  41. ncbi Distribution of Ca2+/calmodulin-dependent protein kinase kinase alpha in the rat central nervous system: an immunohistochemical study
    Y Nakamura
    Department of Anatomy, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Neurosci Lett 204:61-4. 1996
    ..Thus, it was suggested that other types of CaM-kinase IV kinase might exist in the cerebellum, and the present CaM-kinase IV kinase was named as CaM-kinase kinase alpha...
  42. pmc A model of the roles of essential kinases in the induction and expression of late long-term potentiation
    Paul Smolen
    Department of Neurobiology and Anatomy, W M Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, USA
    Biophys J 90:2760-75. 2006
    ..kinase (MAPK), and CaM kinase II (CAMKII) in the vicinity of the synapse, and activation of transcription by CaM kinase IV (CAMKIV) and MAPK. L-LTP is represented by increases in a synaptic weight...
  43. pmc The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of β-cells
    Bo Liu
    Diabetes Research Group, School of Medicine, Division of Diabetes and Nutritional Sciences, King s College London, London, United Kingdom
    PLoS ONE 7:e45711. 2012
    ..response element-binding protein (CREB) and we recently demonstrated that Ca(2+)/calmodulin dependent kinase 4 (CaMK4) is upstream of CREB activation in β-cells...
  44. pmc Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse
    Majid Nikpay
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hypertens Res 35:585-91. 2012
    ..uncovered numerous shared genes among substance use, stress response, obesity and hemodynamic traits, including CAMK4, CNTN4, DLG2, FHIT, GRID2, ITPR2, NOVA1 and PRKCE, forming network of interacting proteins, sharing synaptic ..
  45. pmc Natural variation and genetic covariance in adult hippocampal neurogenesis
    Gerd Kempermann
    Max Delbröck Center for Molecular Medicine, Berlin Buch, 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 103:780-5. 2006
    ..and, of these, six had plausible biological association with adult neurogenesis (Prom1, Ssbp2, Kcnq2, Ndufs2, Camk4, and Kcnj9)...
  46. ncbi Reduced CREB phosphorylation after chronic lithium treatment is associated with down-regulation of CaM kinase IV in rat hippocampus
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milano, Italy
    Int J Neuropsychopharmacol 10:491-6. 2007
    ..of prolonged lithium administration on cAMP responsive element-binding protein (CREB) phosphorylation and CaM kinase IV (CaMKIV), one of the main kinases phosphorylating CREB in neurons following synaptic activation...
  47. ncbi Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections
    Amir H Kashani
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:8398-408. 2006
    ..These observations identify LMO4 as a calcium-dependent transactivator that plays a key role in patterning thalamocortical connections during development...
  48. doi Calmodulin-dependent kinase 1beta is expressed in the epiphyseal growth plate and regulates proliferation of mouse calvarial osteoblasts in vitro
    Mona E Pedersen
    Institute of Basic Medical Sciences, Department of Biochemistry, University of Oslo, Oslo, Norway
    Bone 43:700-7. 2008
    ..family is activated in response to elevation of intracellular Ca(2+), and includes CaMK1 (as well as CaMK2 and CaMK4), which exists as different isoforms (alpha, beta, gamma and delta)...
  49. ncbi Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus
    Eishichi Miyamoto
    Department of Electrical Engineering and Bioscience, Graduate School of Science and Engineering, Waseda University, Tokyo, Japan
    J Pharmacol Sci 100:433-42. 2006
    ..Furthermore, activation of CaM kinase IV and MAPK increased phosphorylation of CREB (cyclic AMP response element binding protein) and expression of c-..
  50. doi Calcium/calmodulin-dependent protein kinases as potential targets of nitric oxide
    Tsuyoshi Takata
    Department of Pharmacology, High Technology Research Center, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Nitric Oxide 25:145-52. 2011
    ..The Ca(2+)/CaM-dependent protein kinases (CaM kinases) such as CaM kinase I, CaM kinase II, and CaM kinase IV, are a family of protein kinases which requires binding of Ca(2+)/CaM to and subsequent phosphorylation of the ..
  51. ncbi Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance
    Christine M Kitsos
    Department of Pharmacology and Cancer Biology, Duke University, Medical Center, Durham, North Carolina 27715, USA
    J Biol Chem 280:33101-8. 2005
    ..Re-expression of CaMKIV in Camk4-/- KLS cells results in the rescue of the proliferation defects in vitro as well as in the restoration of CBP and ..
  52. ncbi Effects of magnesium sulfate administration during hypoxia on CaM kinase IV and protein tyrosine kinase activities in the cerebral cortex of newborn piglets
    Ahmed G Mami
    Department of Pediatric Surgery, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19129, USA
    Neurochem Res 31:57-62. 2006
    ..Cerebral hypoxia was confirmed biochemically by measuring ATP and phosphocreatine (PCr) levels. CaM Kinase IV and PTK activities were determined in Nx, Hx and Mg(2+)-Hx newborn piglets...
  53. doi The effect of cyclosporine A on the phosphorylation of the AMPK pathway in the rat hippocampus
    Hong Geun Park
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 35:1933-7. 2011
    ..CsA did not affect the phosphorylation of Thr-196-Ca(2+)/calmodulin-dependent protein kinase 4 (CaMK4) and the amount of PP2Cα. An increased phosphorylation of Ser-79-ACC and Ser-872-HMG-CoAR was also observed...
  54. ncbi Nuclear Ca(++)-influx, Ca (++)/calmodulin-dependent protein kinase IV activity and CREB protein phosphorylation during post-hypoxic reoxygenation in neuronal nuclei of newborn piglets: the role of nitric oxide
    Om Prakash Mishra
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, New College Building, Philadelphia, PA 19102, USA
    Neurochem Res 31:1463-71. 2006
    ..Nuclear Ca(++)-influx was determined using (45)Ca(++) and CaM kinase IV activity determined by (33)P-incorporation into syntide-2...
  55. ncbi Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
    Kojiro Sato
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Japan
    Nat Med 12:1410-6. 2006
    ..Pharmacological inhibition of CaMKs as well as the genetic ablation of Camk4 reduced CREB phosphorylation and downregulated the expression of c-Fos, which is required for the induction of ..
  56. doi Early induction of CREB activation and CREB-regulating signalling by antidepressants
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Italy
    Int J Neuropsychopharmacol 12:1367-81. 2009
    ..The results also showed that, contrary to the activatory role of MAP-ERKs and CaM kinase IV, nuclear alphaCaM kinase II was inactivated in parallel with activation of CREB.
  57. pmc In vivo selection of kinase-responsive RNA elements controlling alternative splicing
    Hongzhao Li
    Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada
    J Biol Chem 284:16191-201. 2009
    ..Interestingly, a CAAAAAA motif is sufficient for the PKA/CaMKIV-regulated splicing of the exon 16 of the CaMK kinase beta1 (CaMKK2) transcripts, implying a role of this motif in signaling cross-talk or feedback regulation ..
  58. doi Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller
    Luigi Racioppi
    Department of Molecular and Cellular Biology and Pathology, University of Naples Federico II, Naples, Italy
    Trends Immunol 29:600-7. 2008
    ..which controls the activation status of many enzymes, including the Ca(2+)/CaM-dependent Ser-Thr kinases (CaMK) I, II and IV...
  59. pmc Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling
    Marioly Müller
    Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:13293-8. 2011
    ..activation was associated with and dependent on constitutive activation of Ca(2+)/CaM kinase kinase β and CaM kinase IV (CaMKIV)...
  60. pmc Evolution of the aging brain transcriptome and synaptic regulation
    Patrick M Loerch
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 3:e3329. 2008
    ..D (APOD) and downregulation of the synaptic cAMP signaling gene calcium/calmodulin-dependent protein kinase IV (CAMK4)...
  61. pmc Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification
    Wagner B Dias
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 284:21327-37. 2009
    ..This is the first example of an O-GlcNAc/phosphate cycle involving O-GlcNAc transferase/kinase cross-talk...
  62. pmc An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons
    Ji Ann Lee
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 23:2284-93. 2009
    Neuronal depolarization and CaM kinase IV signaling alter the splicing of multiple exons in transcripts for ion channels, neurotransmitter receptors, and other synaptic proteins...
  63. doi Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins
    Alberto Malovini
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Pavia, Italy
    Rejuvenation Res 14:283-91. 2011
    ..In conclusion, prolongevity genes are activated by CAMKIV, the levels of which are influenced by rs10491334, a SNP associated with human longevity...
  64. doi Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 8
    Carmen Grijota-Martinez
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Endocrinology 152:1713-21. 2011
    ..Gene expression was then measured in the fetal cerebral cortex. T4 increased Camk4, Sema3c, and Slc7a3 expression, but T3 was without effect...
  65. pmc Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice
    Miriam Schneider
    Central Institute of Mental Health ZI, Department of Psychopharmacology, J5, 68159 Mannheim, Germany
    BMC Neurosci 8:105. 2007
    ..In the present study, we aimed at specifically dissecting the role of CaMKIV in the nucleus accumbens of adult mice...
  66. ncbi Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites
    D S Bredt
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 267:10976-81. 1992
    ..We demonstrate that purified NOS is labeled by a photoaffinity derivative of calmodulin. These recognition sites on NOS provide multiple means for regulation of NO levels and "cross-talk" between second messenger systems...
  67. pmc Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements
    Ji Ann Lee
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America
    PLoS Biol 5:e40. 2007
    ..One of these exonic elements is similar to an intronic CaMK IV-responsive RNA element (CaRRE) originally identified in the 3' splice site of the BK channel STREX exon, but not ..
  68. pmc Gfer is a critical regulator of HSC proliferation
    Uma Sankar
    James Graham Brown Cancer Center and Owensboro Cancer Research Program, Department of Pharmacology and Toxicology, University of Louisville, Lousville, KY, USA
    Cell Cycle 10:2263-8. 2011
    ..Highly proliferative and functionally deficient Camk4-/- HSCs possess significantly lower levels of Gfer and p27kip1...
  69. pmc Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation
    Fan Pan
    Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    EMBO J 24:2104-13. 2005
    ..CaMKIV-mediated nuclear export of Cabin1 is likely to account for a significant part of the requirement of CaMKIV during human T-cell activation...
  70. pmc Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex
    K F Jensen
    Neurotoxicology Division, Environmental Protection Agency, Research Triangle Park, NC 27711
    Proc Natl Acad Sci U S A 88:2850-3. 1991
    ..Immunoblots confirmed these findings. Thus, CaM kinase-Gr may mediate and coordinate Ca2(+)-signaling within different subcellular compartments...
  71. ncbi Regulation of CREB phosphorylation by cAMP and Ca2+ in parotid acinar cells
    T Takuma
    Department of Oral Biochemistry, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Japan
    Biochem Mol Biol Int 43:563-70. 1997
    ..b>CaM kinase IV, a putative protein kinase for CREB in response to Ca2+ elevation, was undetectable in parotid acinar cells.
  72. ncbi CREB-induced transcriptional activation depends on mGluR6 in rod bipolar cells
    K Yoshida
    Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan
    Brain Res Mol Brain Res 57:241-7. 1998
    ..INL were also immunopositive for anti-protein kinase C alpha (PKC alpha), a marker of rod bipolar cells, while CaM kinase IV immunoreactivity was not detected in these cells...
  73. ncbi Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase
    M Matsushita
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:21473-81. 1998
    ..of the enzyme by calmodulin (CaM) also allows CaMKI to be phosphorylated and activated by a second enzyme, CaMK kinase (CaMKK)...
  74. ncbi Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain
    H Tokumitsu
    Helix Research Institute, Inc, 1532 3 Yana, Kisarazu shi, Chiba 292 0812, Japan
    J Biol Chem 274:15803-10. 1999
    ..kinase (CaM-KK) has been identified and cloned as an activator for two kinases, CaM kinase I (CaM-KI) and CaM kinase IV (CaM-KIV), and a recent report (Yano, S., Tokumitsu, H., and Soderling, T. R...
  75. ncbi Ca(2+)/Calmodulin-dependent protein kinase cascade in Caenorhabditis elegans. Implication in transcriptional activation
    K Eto
    Helix Research Institute, Inc, 1532 3 Yana, Kisarazu shi, Chiba 292 0812, Japan
    J Biol Chem 274:22556-62. 1999
    ..elegans and is functionally operated both in vitro and in intact cells, and it may be involved in Ca(2+)-dependent nuclear events such as transcriptional activation through phosphorylation of CREB...
  76. pmc WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A
    C S Moreno
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 275:5257-63. 2000
    ..Thus, one mechanism of targeting and organizing PP2A with components of Ca(2+)-dependent signaling pathways may be through the molecular scaffolding proteins striatin and SG2NA...
  77. ncbi Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells
    K Komeima
    Departments of Pharmacology and Ophthalmology, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 275:28139-43. 2000
    ..Thus, our results indicate that Ca(2+) triggers cross-talk signal transduction between CaM kinase and NO and CaM-K IIalpha phosphorylating nNOS on Ser(847), which in turn decreases the gaseous second messenger NO in neuronal cells...
  78. ncbi Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression
    N Ban
    Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
    Diabetes 49:1142-8. 2000
    ..These results suggest a mechanism in which ATF-2 regulates insulin gene expression in pancreatic beta-cells, with the transcriptional activity of ATF-2 being increased by an elevated concentration of calcium ions...
  79. ncbi Regulation of neuronal nitric-oxide synthase by calmodulin kinases
    Y Hayashi
    Department of Pharmacology, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 274:20597-602. 1999
    ..kinases (CaM kinases) including CaM kinase Ialpha (CaM-K Ialpha), CaM kinase IIalpha (CaM-K IIalpha), and CaM kinase IV (CaM-K IV), was studied...
  80. pmc Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18
    H Melander Gradin
    Department for Cell and Molecular Biology, University of Umea, Sweden
    Mol Cell Biol 17:3459-67. 1997
    ..on Ser-25 by the mitogen-activated protein kinase and on Ser-16 by the Ca2+/calmodulin-dependent kinase IV/Gr (CaMK IV/Gr)...
  81. ncbi Evidence for the existence of Ca2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 119:1176-81. 1996
    ..Thus, at least two distinct isoforms of CaM-kinase IV kinase appear to exist in the brain...
  82. ncbi Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV
    J M Sikela
    Department of Pharmacology, University of Colorado School of Medicine, Denver 80262
    Genomics 4:21-7. 1989
    ..On the basis of structural and immunological features, we refer to this new kinase as CaM Kinase IV. Two cDNA clones were used to identify CaM Kinase IV: The downstream clone, lambda ICM-1, contains the ..
  83. ncbi Full activation of brain calmodulin-dependent protein kinase IV requires phosphorylation of the amino-terminal serine-rich region by calmodulin-dependent protein kinase IV kinase
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 117:686-90. 1995
    ..The initial phosphorylation occurred in the amino-terminal serine-rich region of CaM-kinase IV. Kinetic analysis revealed that the increase in the activity upon phosphorylation was due mainly to an increase in the Vmax values...
  84. ncbi Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    J Biol Chem 270:19320-4. 1995
    ..These results are consistent with the hypothesis that CaM-kinases I and IV are regulated through a unique signal transduction cascade involving CaM-kinase kinase...
  85. ncbi Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    J Biol Chem 269:28640-7. 1994
    ..Sun, P., Brickey, D., Soderling, S. H., Klamo, E., and Soderling, T.R. (1994) J. Biol. Chem. 269, 15520-15527)...
  86. ncbi cDNA cloning and expression of human calmodulin-dependent protein kinase IV
    T Kitani
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 115:637-40. 1994
    ..The antibody also cross-reacted with both isoforms of CaM-kinase IV from rat cerebellum, the apparent molecular weights being 62,000 and 64,000, respectively...
  87. pmc A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1
    G Mosialos
    Department of Medicine, Harvard Medical School, Boston, Massachusetts
    J Virol 68:1697-705. 1994
    ..In view of the key role played by LMP1 in B-lymphocyte immortalization by EBV, these findings implicate CaM kinase-Gr as a potential mediator of B-lymphocyte growth transformation...
  88. ncbi The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus
    M M Bland
    Wellcome Research Laboratories, Research Triangle Park, NC 27709
    Gene 142:191-7. 1994
    ..The human antiserum cross-reacts with the rat and mouse proteins and immunoprecipitates the active kinase...
  89. ncbi Requirements for calcium and calmodulin in the calmodulin kinase activation cascade
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 271:5617-22. 1996
    ....
  90. ncbi Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence
    A M Edelman
    Department of Pharmacology and Toxicology, State University of New York, Buffalo 14214, USA
    J Biol Chem 271:10806-10. 1996
    ..Both CaMKIK alpha and CaMKIK beta are also capable of activating CaM kinase IV. Activation of CaM kinase I and CaM kinase IV occurs via phosphorylation of an equivalent Thr residue within ..
  91. pmc CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner
    G A Wayman
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Cell Biol 151:811-24. 2000
    ....
  92. ncbi Phosphorylation of calmodulin by Ca2+/calmodulin-dependent protein kinase IV
    Atsuhiko Ishida
    Department of Biochemistry, Asahikawa Medical College, Asahikawa, Japan
    Arch Biochem Biophys 407:72-82. 2002
    ..Thus, CaM-kinase IV activated by binding Ca2+/CaM can bind and phosphorylate another CaM with the aid of poly(Lys), leading to a decrease in the activity of CaM...
  93. ncbi The effect of hypocapnia (PaCO2 27 mmHg) on CaM kinase IV activity, Bax/Bcl-2 protein expression and DNA fragmentation in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Neonatology Research Laboratories, Medical College of Pennsylvania, Philadelphia, PA 19129, USA
    Neurosci Lett 352:211-5. 2003
    ..of 27 mmHg for 1 hr results in increased neuronal nuclear Ca(++)/calmodulin-dependent protein kinase IV (CaM kinase IV) activity, pro-apoptotic protein expression and DNA fragmentation in the cerebral cortex of newborn piglets...
  94. ncbi The effect of moderate hypocapnic ventilation on nuclear Ca2+-ATPase activity, nuclear Ca2+ flux, and Ca2+/calmodulin kinase IV activity in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Neonatology Research Laboratories, Philadelphia, Pennsylvania 19134, USA
    Neurochem Res 29:791-6. 2004
    ..PCr) levels and increased nuclear high-affinity Ca++-ATPase activity, intranuclear Ca++ flux, and CaM kinase IV activity in neuronal nuclei of piglets...
  95. ncbi Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex
    Kristin A Anderson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:31708-16. 2004
    ..tightly regulated event requiring both Ca(2+)/CaM binding and phosphorylation of the kinase on T200 by an upstream CaMK kinase (CaMKK)...
  96. ncbi Generation of a polyclonal antibody that simultaneously detects multiple Ser/Thr protein kinases
    Isamu Kameshita
    Faculty of Agriculture, Department of Life Sciences, Kagawa University, Miki cho, Kagawa 761 0795, Japan
    J Biochem Biophys Methods 60:13-22. 2004
    ..The present anti-peptide antibody with a broad spectrum of cross-reactivity to multiple protein kinases may be a powerful tool for comprehensive analysis focused on protein kinases...
  97. ncbi Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells
    E Yamamori
    Department of Medicine, Nagoya University Graduate School of Medicine and Hospital, Nagoya 466 8550, Japan
    J Mol Endocrinol 33:639-49. 2004
    ..RT-PCR analysis confirmed the expression of CaMK as well as CRH mRNA in BE(2)C cells. When we introduced approximately 1...
  98. ncbi Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Asahikawa 078 8510, Japan
    J Biochem 130:503-13. 2001
    ..The changes in the activity of the enzyme upon phosphorylation appear to occur as a result of conformational changes induced by phosphorylation on several sites...
  99. pmc Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin
    J Y Wu
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 21:6066-70. 2001
    Calspermin and Ca(2+)-calmodulin-dependent protein kinase IV (CaMKIV) are two proteins encoded by the Camk4 gene. CaMKIV is found in multiple tissues, including brain, thymus, and testis, while calspermin is restricted to the testis...
  100. ncbi Post-translational excision of the carboxyl-terminal segment of CaM kinase phosphatase N and its cytosolic occurrence in the brain
    Takako Kitani
    Department of Biochemistry, Asahikawa Medical College, Asahikawa, Japan
    J Neurochem 96:374-84. 2006
    ..against the carboxyl-terminal segment of the enzyme, indicating its involvement in the deactivation of CaM kinase IV. Here, we show that the majority of the naturally occurring CaM kinase phosphatase N in the brain exists not ..
  101. ncbi Nitric oxide-mediated Ca2+/calmodulin-dependent protein kinase IV activity during hypoxia in neuronal nuclei from newborn piglets
    Alan B Zubrow
    Department of Pediatrics, College of Medicine, Drexel University, Philadelphia, PA, USA
    Neurosci Lett 335:5-8. 2002
    ..study tested the hypothesis that hypoxia results in increased Ca(2+)/calmodulin-dependent protein kinase IV (CaM kinase IV) activity and that inhibition of nitric oxide (NO) synthase by N-nitro-L-arginine (NNLA) prevents the hypoxia- ..

Research Grants65

  1. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2009
    ..PI 4-kinase 2, inositol trisphosphate receptors, CREB, neuronal apoptotic inhibitory protein, CaM kinase II, CaM kinase IV, and calcineurin; 3) the expression and/or functional characteristics of these target proteins...
  2. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2010
    ..PI 4-kinase 2, inositol trisphosphate receptors, CREB, neuronal apoptotic inhibitory protein, CaM kinase II, CaM kinase IV, and calcineurin;3) the expression and/or functional characteristics of these target proteins...
  3. GENETIC ANALYSIS OF SIGNALING BY CARDIAC ENDOTHELIN-1
    Ralph Shohet; Fiscal Year: 2004
    ..3) To determine the effect of ET-1 ablation on the response of the CNA, CamK4 and MAPK dependent hypertrophic pathways...
  4. IN VIVO CEREBRAL OXIDATIVE METABOLISM IN HYPOXIC NEWBORNS
    MARIA D DELIVORIA PAPADOPOULOS; Fiscal Year: 2010
    ..proposed studies will investigate the mechanism of activation of Ca++/calmodulin-dependent protein kinase IV (CaM kinase IV) during hypoxia that leads to activation of cyclic AMP-response element binding (CREB) protein and triggers ..
  5. Estrogen and CaM Kinase IV in the Limbic System
    ROCHELLE COHEN; Fiscal Year: 2006
    ..We propose that the Ca2+/calmodulin-dependent protein kinase IV (CaMK IV) pathway, "CaMK IV - CREB - phosphorylated CREB (pCREB) - BDNF," mediates some of the effects of long-term E2 ..
  6. BIOLOGY OF THE TESTIS
    ANTHONY MEANS; Fiscal Year: 2005
    ..b>Camk4-/- mice are male (and female) infertile, unable to mount a type 2 immune response and exhibit profound loss of ..
  7. Calmodulin Dependent Protein Kinase Kinase
    THOMAS SODERLING; Fiscal Year: 2005
    ..These studies will further our understanding of the functions of CaM-KK in cellular Ca2+ signaling and their roles in neurotransmitter/hormone responses, neuronal development and cell death, and synaptic plasticity. ..
  8. Calcium signaling in neuronal differentiation
    Lori Redmond; Fiscal Year: 2007
    ..Activity induced dendritic complexity is mediated by the sequential activation of CaM kinase IV and CREB/CBP-mediated signaling...
  9. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
    ..of the CRE binding protein (CREB) and the CREB binding protein (CPB) through intracellular Ca2+ activation of CaM kinase IV and the Ras/MEK/ERK pathway...
  10. CaM Kinase Cascades in Endocrine Cells
    ANTHONY MEANS; Fiscal Year: 2009
    ..Analysis of Camk4~'~ mice identified a CaMKIV cascade in hematopoeitic stem cells (HSC) and cerebellar granule cells that ..
  11. CaM Kinase Cascades in Endocrine Cells
    Anthony R Means; Fiscal Year: 2010
    ..Analysis of Camk4~'~ mice identified a CaMKIV cascade in hematopoeitic stem cells (HSC) and cerebellar granule cells that ..
  12. CaM Kinase Cascades in Endocrine Cells
    ANTHONY MEANS; Fiscal Year: 2007
    ..Analysis of Camk4~'~ mice identified a CaMKIV cascade in hematopoeitic stem cells (HSC) and cerebellar granule cells that regulates ..
  13. CALMODULIN DEPENDENT PROTEIN KINASES
    THOMAS SODERLING; Fiscal Year: 2001
    ..These studies will further our understanding of the enzymatic and regulatory properties of these key signaling proteins, thereby furthering our understanding of their roles in hormone actions, learning and memory, epilepsy and stroke. ..
  14. TRANSCRIPTIONAL CONTROL OF CARDIAC HYPERTROPHY
    Eric Olson; Fiscal Year: 2002
    ..Calcineurin has also been shown to synergize with PKC and CaM kinase IV to activate the transcription of MEF2-responsive genes, but the mechanism involved has not been defined...
  15. CEREBRAL OXIDATIVE METABOLISM IN HYPOXIC NEWBORNS
    Maria Delivoria Papadopoulos; Fiscal Year: 2007
    ..proteins, Bax and Bad, is mediated through the increased activation of the Ca++-dependent kinase IV (CaM kinase IV) cascade, and results in phosphorylation of cyclic AMP-responsive element binding (CREB) protein at ser 133...