Gene Symbol: CAMK2G
Description: calcium/calmodulin dependent protein kinase II gamma
Alias: CAMK, CAMK-II, CAMKG, calcium/calmodulin-dependent protein kinase type II subunit gamma, caMK-II subunit gamma, calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
Species: human
Products:     CAMK2G

Top Publications

  1. Gaertner T, Kolodziej S, Wang D, Kobayashi R, Koomen J, Stoops J, et al. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. J Biol Chem. 2004;279:12484-94 pubmed
    ..Simulations utilizing this data revealed that the measured differences in CaM binding affinities play a minor role in the autophosphorylation of the enzyme, which is largely dictated by the rate of autophosphorylation for each isoform. ..
  2. Robison A, Bass M, Jiao Y, MacMillan L, Carmody L, Bartlett R, et al. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J Biol Chem. 2005;280:35329-36 pubmed
  3. Chelu M, Sarma S, Sood S, Wang S, van Oort R, Skapura D, et al. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009;119:1940-51 pubmed
    ..Together, these findings suggest that increased RyR2-dependent Ca2+ leakage due to enhanced CaMKII activity is an important downstream effect of CaMKII in individuals susceptible to AF induction. ..
  4. Rellos P, Pike A, Niesen F, Salah E, Lee W, von Delft F, et al. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 2010;8:e1000426 pubmed publisher
    ..Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the Web plugin are available in Text S1. ..
  5. Larsson S, Jones H, Göransson O, Degerman E, Holm C. Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase. Cell Signal. 2016;28:204-213 pubmed publisher
    ..ERK), protein kinase B (PKB), AMP-activated protein kinase (AMPK) and Ca(2+)/calmodulin-dependent protein kinase (CaMK) had little or no effect...
  6. Boneh A. Signal transduction in inherited metabolic disorders: a model for a possible pathogenetic mechanism. J Inherit Metab Dis. 2015;38:729-40 pubmed publisher
    ..They act through protein kinase C, calcium dependent kinases (CamK) and phosphatase (CN), 'stress-mediated' kinases (MAPK) and AMP/ATP-dependent kinase (AMPK)...
  7. Llanos P, Contreras Ferrat A, Georgiev T, Osorio Fuentealba C, Espinosa A, Hidalgo J, et al. The cholesterol-lowering agent methyl-β-cyclodextrin promotes glucose uptake via GLUT4 in adult muscle fibers and reduces insulin resistance in obese mice. Am J Physiol Endocrinol Metab. 2015;308:E294-305 pubmed publisher
    ..In fibers from HFD-fed mice, MβCD improved insulin sensitivity even after Akt or CaMK II inhibition and increased membrane GLUT4 content...
  8. Seeher S, Carlson B, Miniard A, Wirth E, Mahdi Y, Hatfield D, et al. Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice. Biochem J. 2014;462:67-75 pubmed publisher
    ..Neuron-specific inactivation of Secisbp2 (CamK-Cre; Secisbp2fl/fl) reduced cerebral expression of selenoproteins to a lesser extent than inactivation of tRNA[Ser]..
  9. Nishi H, Maeda N, Izumi S, Higa Nakamine S, Toku S, Kakinohana M, et al. Differential regulation of epidermal growth factor receptor by hydrogen peroxide and flagellin in cultured lung alveolar epithelial cells. Eur J Pharmacol. 2015;748:133-42 pubmed publisher
    ..These results strongly suggested that hydrogen peroxide activated the p38 MAPK pathway via activation of CaM kinase II and that flagellin and hydrogen peroxide regulate the functions of EGFR by different mechanisms. ..

More Information

Publications136 found, 100 shown here

  1. Inagaki R, Moriguchi S, Fukunaga K. Aberrant Amygdala-dependent Fear Memory in Corticosterone-treated Mice. Neuroscience. 2018;388:448-459 pubmed publisher
    ..Immunoblot analyses revealed that autophosphorylation of Ca2+/calmodulin-dependent protein kinase (CaMK) IIα at threonine 286 and phosphorylation of cyclic-adenosine-monophosphate response-element-binding protein (CREB)..
  2. Wei Y, Wang Y, Wang Y, Bai L. Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model. Cell Physiol Biochem. 2017;42:319-332 pubmed publisher increasing the production of calmodulin, phosphorylation of calmodulin dependent protein kinases II (p-CAMK II), phosphorylation of Beclin1 (p-Beclin1), and protein of B-cell lymphoma-2 (Bcl-2), and attenuating ratio of LC3-..
  3. Talkhabi M, Razavi S, Salari A. Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming. J Cell Commun Signal. 2017;11:193-204 pubmed publisher
    ..kinases such as protein kinase D1 (PKD1), protein kinase A (PRKA), calcium/calmodulin-dependent protein kinase (CAMK), protein kinase C (PRKC), and insulin like growth factor 1 receptor (IGF1R) that are strongly involved in ..
  4. Sachidanandan D, Reddy H, Mani A, Hyde G, Bera A. The Neuropeptide Orexin-A Inhibits the GABAA Receptor by PKC and Ca2+/CaMKII-Dependent Phosphorylation of Its ?1 Subunit. J Mol Neurosci. 2017;61:459-467 pubmed publisher
    ..In this model, Ox-A/GABAAR crosstalk would cause the depolarising influence of Ox-A to be boosted, a type of positive feedback that could, for example, facilitate the ability to abruptly awake. ..
  5. Yingst D, Davis J, Schiebinger R. Effects of extracellular calcium and potassium on the sodium pump of rat adrenal glomerulosa cells. Am J Physiol Cell Physiol. 2001;280:C119-25 pubmed
    ..The resulting increase in [Ca(2+)](i) may stimulate the sodium pump by activating CaM and/or CaMKII...
  6. Gebauer C, Pignolet B, Yshii L, Mauré E, Bauer J, Liblau R. CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model. Oncoimmunology. 2017;6:e1260212 pubmed publisher
    ..a tumor cell line expressing the hemagglutinin (HA) of influenza virus to induce an anti-tumor response in CamK-HA mice, which express HA in CNS neurons...
  7. Li X, Wang L, Li Y, Zhao N, Zhen L, Fu J, et al. Calcium regulates motility and protein phosphorylation by changing cAMP and ATP concentrations in boar sperm in vitro. Anim Reprod Sci. 2016;172:39-51 pubmed publisher addition of the calmodulin (CaM) inhibitor W7 and the inhibitor of calmodulin-dependent protein kinase (CaMK), KN-93...
  8. Zhao J, Zhou D, Yang J, Song S, Zhang T, Zhu C, et al. Effects of abalone (Haliotis discus hannai Ino) gonad polysaccharides on cholecystokinin release in STC-1 cells and its signaling mechanism. Carbohydr Polym. 2016;151:268-273 pubmed publisher
    ..on calcium-sensing receptor (CaSR), protein kinase A (PKA), Ca(2+)⁄calmodulin-dependent protein kinase (CaMK) II, p38- mitogen-activated protein kinases (MAPK), and an intracellular calcium chelator all inhibited AGP-induced ..
  9. Cheng L, Wu Q, Kortenoeven M, Pisitkun T, Fenton R. A Systems Level Analysis of Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells. Sci Rep. 2015;5:12829 pubmed publisher
    ..Kinase prediction indicated that dDAVP increased AGC and CAMK kinase families' activities and decreased activity of CDK and MAPK families...
  10. Raynal N, Lee J, Wang Y, Beaudry A, Madireddi P, Garriga J, et al. Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer. Cancer Res. 2016;76:1494-505 pubmed publisher
    ..Instead, all 11 drugs altered calcium signaling and triggered calcium-calmodulin kinase (CamK) activity, leading to MeCP2 nuclear exclusion...
  11. Wang Z, Cheng Y, Abraham J, Yan R, Liu X, Chen W, et al. RNA sequencing of esophageal adenocarcinomas identifies novel fusion transcripts, including NPC1-MELK, arising from a complex chromosomal rearrangement. Cancer. 2017;123:3916-3924 pubmed publisher
    ..6%, ubiquitin-specific peptidase 54 (USP54)-calcium/calmodulin dependent protein kinase II γ (CAMK2G) in 2 of 55 or 3.6%, megakaryoblastic leukemia (translocation) 1 (MKL1)-fibulin 1 (FBLN1) in 1 of 55 or 1...
  12. Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
    ..causes ryanodine-sensitive Ca(2+) release which is important for AMPKα-Thr(172) phosphorylation via Ca(2+)/CaMK II. AMPKα-Thr(172) phosphorylation causes [glucose]o uptake (and an [ATP]i increase), closure of KATP channels, ..
  13. York B, Li F, Lin F, Marcelo K, Mao J, Dean A, et al. Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Sci Rep. 2017;7:11793 pubmed publisher
    ..protein kinase kinase 2) is a central member of this kinase family as it controls the actions of a CaMK cascade involving CaMKI, CaMKIV or AMPK...
  14. Zuo D, Liu Y, Liu Z, Cui J, Zhou X, Liu Y, et al. Alcohol aggravates ketamine-induced behavioral, morphological and neurochemical alterations in adolescent rats: The involvement of CREB-related pathways. Behav Brain Res. 2018;349:80-90 pubmed publisher
    ..of Akt (a serine/threonine kinase or protein kinase, PKB), protein kinase A (PKA), calmodulin-dependent kinase IV (CaMK-IV)-mediated cyclic AMP-responsive element binding protein (CREB) pathways and induction of neuronal apoptosis in ..
  15. Sawamoto A, Okuyama S, Amakura Y, Yamada R, Yoshimura M, Nakajima M, et al. Sansoninto as evidence-based remedial medicine for depression-like behavior. J Nat Med. 2018;72:118-126 pubmed publisher
    ..the mitogen-activated protein kinase (MAPK) cascade and Ca2+/calmodulin-dependent protein kinase II (CaMK II) cascade, a downstream signaling cascade of the N-methyl-D-aspartate (NMDA) receptor...
  16. Wang Y, Wang X, Liang X, Wu J, Dong S, Li H, et al. Inhibition of hydrogen sulfide on the proliferation of vascular smooth muscle cells involved in the modulation of calcium sensing receptor in high homocysteine. Exp Cell Res. 2016;347:184-91 pubmed publisher
    ..The results showed that the [Ca(2+)]i and the expression of p-CaMK and CSE increased upon treatment with CaSR agonist...
  17. Liang Z, Zhan Y, Shen Y, Wong C, Yates J, Plattner F, et al. The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat Commun. 2016;7:13282 pubmed publisher
    ..Here we report the identification of 'calmodulin kinase-like vesicle-associated' (CaMKv), a pseudokinase of the CaMK family with unknown function, as a synaptic protein crucial for dendritic spine maintenance...
  18. Qin T, Li N, Tan X, Zheng J, Tao R, Chen M. Works on heart, how about brain? Effect of hyperkalemia on focal cerebral ischemia/reperfusion injury in rats. Eur Rev Med Pharmacol Sci. 2018;22:2839-2846 pubmed publisher
    ..The activity of Ca-ATPase was also elevated, the expression of CaMK II and NCX1 were down-regulated in the two hyperkalemia groups...
  19. Alli A, Bao H, Liu B, Yu L, Aldrugh S, Montgomery D, et al. Calmodulin and CaMKII modulate ENaC activity by regulating the association of MARCKS and the cytoskeleton with the apical membrane. Am J Physiol Renal Physiol. 2015;309:F456-63 pubmed publisher
    ..Taken together, these findings suggest calmodulin and CaMKII modulate ENaC activity by destabilizing the association between the actin cytoskeleton, ENaC, and MARCKS, or MLP-1 at the apical membrane. ..
  20. Tamási V, Petschner P, Adori C, Kirilly E, Ando R, Tothfalusi L, et al. Transcriptional evidence for the role of chronic venlafaxine treatment in neurotrophic signaling and neuroplasticity including also Glutamatergic [corrected] - and insulin-mediated neuronal processes. PLoS ONE. 2014;9:e113662 pubmed publisher neurotrophic signaling (Ntrk2, Ntrk3), glutamatergic transmission (Gria3, Grin2b and Grin2a), neuroplasticity (Camk2g/b, Cd47), synaptogenesis (Epha5a, Gad2) and cognitive processes (Clstn2)...
  21. Sung U, Binda F, Savchenko V, Owens W, Daws L. Ca2+ dependent surface trafficking of norepinephrine transporters depends on threonine 30 and Ca2+ calmodulin kinases. J Chem Neuroanat. 2017;83-84:19-35 pubmed publisher
    ..K+ increased NET surface expression in a process that required external Ca2+ and depended on CaMK activity...
  22. Chinpongpanich A, Phean o pas S, Thongchuang M, Qu L, Buaboocha T. C-terminal extension of calmodulin-like 3 protein from Oryza sativa L.: interaction with a high mobility group target protein. Acta Biochim Biophys Sin (Shanghai). 2015;47:880-9 pubmed publisher
    ..Taken together, OsCML3 probably provides a mechanism for manipulating the DNA-binding ability of OsHMGB1 in the nucleus and its C-terminal extension provides an intracellular Ca2+ regulatory switch. ..
  23. Sun L, Jia H, Ma L, Yu M, Yang Y, Liu Y, et al. Metabolic profiling of hypoxia/reoxygenation injury in H9c2 cells reveals the accumulation of phytosphingosine and the vital role of Dan-Shen in Xin-Ke-Shu. Phytomedicine. 2018;49:83-94 pubmed publisher
    ..In agreement with this, a western blot analysis showed that XKS markedly regulated the over-expression of CaMK II and cleaved caspase-3...
  24. Evans P, Parra Bueno P, Smirnov M, Lustberg D, Dudek S, Hepler J, et al. RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling. Eneuro. 2018;5: pubmed publisher
    ..knockout (KO) of RGS14 in mice requires Ca2+-dependent postsynaptic signaling through NMDA receptors, CaMK, and PKA, revealing similar mechanisms to those in CA1...
  25. Chandrika A, Steephan M, Raveendran Nair R, Sudarsana Devi S, Kumar M, Paul S, et al. A simple end-point assay for calcium channel activity. Cell Calcium. 2018;74:73-85 pubmed publisher
    ..This technique being simple and less expensive could significantly facilitate high throughput screening in calcium channel drug discovery. ..
  26. Scicchitano B, Spath L, Musaro A, Molinaro M, Rosenthal N, Nervi C, et al. Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways. Mol Biol Cell. 2005;16:3632-41 pubmed
    ..The cooperative role of calcineurin and Ca2+/calmodulin-dependent kinase (CaMK) in AVP-dependent differentiation is demonstrated by the effect of inhibitors of the two pathways...
  27. Potet F, Beckermann T, Kunic J, George A. Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels. Circ Arrhythm Electrophysiol. 2015;8:933-41 pubmed publisher
    ..These findings offer a plausible explanation for the lower arrhythmia risk in LQT3 subjects during fast heart rates. ..
  28. Gómez Hierro A, Lambea E, Giménez Zaragoza D, López Avilés S, Yance Chávez T, Montserrat M, et al. Ssp1 CaMKK: A Sensor of Actin Polarization That Controls Mitotic Commitment through Srk1 in Schizosaccharomyces pombe. PLoS ONE. 2015;10:e0143037 pubmed publisher
    ..Here we report that Ssp1 controls the G2/M transition by regulating the activity of the CaMK Srk1...
  29. Liou B, Peng Y, Li R, Inskeep V, Zhang W, Quinn B, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016;25:5126-5141 pubmed publisher
    ..Dantrolene treatment partially normalized Ryr expression and its potential regulators, CAMK IV and calmodulin. Furthermore, dantrolene treatment increased residual mutant GCase activity in 4L;C* brains...
  30. Nicoll R, Malenka R. Expression mechanisms underlying NMDA receptor-dependent long-term potentiation. Ann N Y Acad Sci. 1999;868:515-25 pubmed
    ..Future directions for research in this field include activity-dependent targeting of glutamate receptors and the functional consequences of phosphorylation of AMPA receptors...
  31. Martorana F, Gaglio D, Bianco M, Aprea F, Virtuoso A, Bonanomi M, et al. Differentiation by nerve growth factor (NGF) involves mechanisms of crosstalk between energy homeostasis and mitochondrial remodeling. Cell Death Dis. 2018;9:391 pubmed publisher
    ..NGF differentiation involves the induction of P-AMPK and P-CaMK, and is prevented by their pharmacological inhibition...
  32. Ow J, Palanichamy Kala M, Rao V, Choi M, Bharathy N, Taneja R. G9a inhibits MEF2C activity to control sarcomere assembly. Sci Rep. 2016;6:34163 pubmed publisher
    ..Activation of calcium signaling or expression of constitutively active CaMK rescues G9a-mediated repression of HDAC5 shuttling as well as sarcomere gene expression...
  33. Zhao R, Wang S, Huang Z, Zhang L, Yang X, Bai X, et al. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Biosci Trends. 2015;9:367-76 pubmed publisher
    ..and led to significant increases in levels of phosphorylated calcium/calmodulin-dependent protein kinase type II (CaMK-II), inducible NOS (iNOS) and PKG-I as well as active p38 MAPK...
  34. Gong J, Qiu C, Huang D, Zhang Y, Yu S, Zeng C. Integrative functional analysis of super enhancer SNPs for coronary artery disease. J Hum Genet. 2018;63:627-638 pubmed publisher
    ..Interestingly, we found 7 novel functional loci (CBFA2T3, ZMIZ1, DIP2B, SCNN1D/ACAP3, TMEM105, CAMK2G, and MAPK1) that CAD-associated super enhancer SNPs were clustered into the same or neighboring super enhancers...
  35. Yamamoto H. [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]. Tanpakushitsu Kakusan Koso. 2002;47:241-7 pubmed
  36. Trencia A, Perfetti A, Cassese A, Vigliotta G, Miele C, Oriente F, et al. Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action. Mol Cell Biol. 2003;23:4511-21 pubmed
    ..Thus, phosphorylation by Akt regulates the antiapoptotic function of PED/PEA-15 at least in part by controlling the stability of PED/PEA-15. In part, Akt survival signaling may be mediated by PED/PEA-15. ..
  37. Vest R, O Leary H, Bayer K. Differential regulation by ATP versus ADP further links CaMKII aggregation to ischemic conditions. FEBS Lett. 2009;583:3577-81 pubmed publisher
    ..These results clarify a previously apparent paradox in the nucleotide and phosphorylation requirement of aggregation, and support a mechanism that involves inter-holoenzyme T286-region/T-site interaction. ..
  38. Ahmed Z, Bernstein S, Ahmed Z, Khan S, Griffith A, Morell R, et al. Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F. Am J Hum Genet. 2001;69:25-34 pubmed
    ..A Northern blot probed with the PCDH15 cytoplasmic domain showed expression in the retina, consistent with its pathogenetic role in the retinitis pigmentosa associated with USH1F. ..
  39. Dimberg A, Karlberg I, Nilsson K, Oberg F. Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells. Blood. 2003;102:254-61 pubmed
  40. Coultrap S, Barcomb K, Bayer K. A significant but rather mild contribution of T286 autophosphorylation to Ca2+/CaM-stimulated CaMKII activity. PLoS ONE. 2012;7:e37176 pubmed publisher
    ..This indicates that the phenotype of CaMKII T286A mutant mice is indeed due to the lack of autonomous activity, as the T286A mutant showed no dramatic reduction in stimulated activity. ..
  41. Kaur S, Kong C, Cannell M, Ward M. Depotentiation of intact rat cardiac muscle unmasks an Epac-dependent increase in myofilament Ca(2+) sensitivity. Clin Exp Pharmacol Physiol. 2016;43:88-94 pubmed publisher
    ..sensitivity, an effect that was blocked by addition of KN-93, a Ca(2+)/calmodulin-dependent protein kinase II (CaMK-II) inhibitor...
  42. Xu D, Peng Y. Apolipoprotein E 4 triggers multiple pathway-mediated Ca2+ overload, causes CaMK II phosphorylation abnormity and aggravates oxidative stress caused cerebral cortical neuron damage. Eur Rev Med Pharmacol Sci. 2017;21:5717-5728 pubmed publisher
    ..Western blot was used to detect phosphorylated CaMK II (p-CaMK II) and cleaved caspase 3 expression...
  43. Lin C, Bai J, He M, Wong A. Grass Carp Prolactin Gene: Structural Characterization and Signal Transduction for PACAP-induced Prolactin Promoter Activity. Sci Rep. 2018;8:4655 pubmed publisher
    ..Apparently, other signaling pathways, including PLC/IP3 and PI3K/P70S6K cascades, may also be involved in PACAP induction of PRL gene transcription. ..
  44. Psenakova K, Petrvalska O, Kylarova S, Lentini Santo D, Kalabova D, Herman P, et al. 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim Biophys Acta Gen Subj. 2018;1862:1612-1625 pubmed publisher
    ..protein kinase kinase 2 (CaMKK2) is a member of the Ca2+/calmodulin-dependent kinase (CaMK) family involved in adiposity regulation, glucose homeostasis and cancer...
  45. Malik B, Gillespie J, Hodge J. CASK and CaMKII function in the mushroom body ?'/?' neurons during Drosophila memory formation. Front Neural Circuits. 2013;7:52 pubmed publisher
    ..We show deletion of full length CASK or just its CaMK-like and L27 domains disrupts middle-term memory (MTM) and long-term memory (LTM), with CASK function in the ?'/?' ..
  46. Hargus N, Thayer S. Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture. J Neurosci. 2013;33:17908-20 pubmed publisher
  47. Andersen D, Tannenberg A, Burke C, Dodd P. Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation. Brain Res Dev Brain Res. 1995;88:178-85 pubmed
    ..The evidence suggests that Glutamate-NMDA binding sites may undergo structural rearrangements which alter their ability to interact with ligands during the later stages of human gestation, and that such changes are regionally variable. ..
  48. Cairns B, Svensson P, Wang K, Hupfeld S, Graven Nielsen T, Sessle B, et al. Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol. 2003;90:2098-105 pubmed
    ..It is conceivable that activation of peripheral NMDA receptors may contribute to masticatory muscle pain and that peripherally acting NMDA receptor antagonists could prove to be effective analgesics for this type of pain. ..
  49. Zhu J, Reynet C, Caldwell J, Kahn C. Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity. J Biol Chem. 1995;270:4805-12 pubmed
    ..Rad may also be phosphorylated on serine/threonine residues by PKA and other kinases, as well as regulated by its own GAP which is present in many tissues and cell types. ..
  50. Dai L, Zhuang L, Zhang B, Wang F, Chen X, Xia C, et al. DAG/PKCδ and IP3/Ca²⁺/CaMK IIβ Operate in Parallel to Each Other in PLCγ1-Driven Cell Proliferation and Migration of Human Gastric Adenocarcinoma Cells, through Akt/mTOR/S6 Pathway. Int J Mol Sci. 2015;16:28510-22 pubmed publisher
    ..kinase C (PKC) and inositol 1,4,5-trisphosphate (IP3)/Ca(2+)/calmodulin-dependent protein kinase II (CaMK II) axes to regulate import events in some cancer cells, including gastric adenocarcinoma cells...
  51. Moss B, Park L, Dahlberg C, Juo P. The CaM Kinase CMK-1 Mediates a Negative Feedback Mechanism Coupling the C. elegans Glutamate Receptor GLR-1 with Its Own Transcription. PLoS Genet. 2016;12:e1006180 pubmed publisher
    ..We identify the CMK-1/CaMK signaling axis as a mediator of the glr-1 transcriptional feedback mechanism...
  52. de Assis L, Moraes M, Magalhães Marques K, Castrucci A. Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin. Eur J Cell Biol. 2018;97:150-162 pubmed publisher
    ..types we have shown that: a) intracellular calcium signal is necessary for UVA-induced IPD; b) the involvement of CaMK II, whose inhibition, abolished the UVA-induced IPD; c) the role of CAMK II/NOS/sGC/cGMP pathway in the process ..
  53. Barria A, Derkach V, Soderling T. Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. J Biol Chem. 1997;272:32727-30 pubmed
    ..W., O'Brien, R. J., Mammen, A. L., Bernhardt, J., and Huganir, R. L. (1996) Neuron 16, 1179-1188), this raises the possibility of synergistic interactions between CaM-KII and protein kinase C in regulating synaptic plasticity. ..
  54. Bossuyt J, Helmstadter K, Wu X, Clements Jewery H, Haworth R, Avkiran M, et al. Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res. 2008;102:695-702 pubmed publisher
    ..This may directly contribute to the development and/or maintenance of HF. ..
  55. Maubach G, Sokolova O, Wolfien M, Rothkötter H, Naumann M. Ca2+/calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection. Int J Cancer. 2013;133:1507-12 pubmed publisher
    ..pylori infection augment the understanding of the molecular mechanism involved and provide potential new disease markers for the diagnosis of gastric inflammatory diseases including gastric cancer. ..
  56. Liu Z, Huang Y, Liu L, Zhang L. Inhibitions of PKC and CaMK-II synergistically rescue ischemia-induced astrocytic dysfunction. Neurosci Lett. 2017;657:199-203 pubmed publisher
    ..reuptake remain unclear, which we have studied by analyzing the effect of calmodulin-dependent protein kinase II (CaMK-II) and protein kinase C (PKC) inhibitions on astrocytic glutamate transporter during ischemia...
  57. Carruthers N, Rosenspire A, Caruso J, Stemmer P. Low level Hg2+ exposure modulates the B-cell cytoskeletal phosphoproteome. J Proteomics. 2018;173:107-114 pubmed publisher
    ..These findings indicate that the actions of mercury on B-cell immune function and development are at least in part likely mediated through changes in cytoskeletal protein phosphorylation. ..
  58. Vulliet P, Woodgett J, Cohen P. Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase. J Biol Chem. 1984;259:13680-3 pubmed
    ..The possibility that this protein kinase is involved in the regulation of tyrosine hydroxylase activity in adrenergic tissue in vivo is discussed. ..
  59. Breen M, Ashcroft S. A truncated isoform of Ca2+/calmodulin-dependent protein kinase II expressed in human islets of Langerhans may result from trans-splicing. FEBS Lett. 1997;409:375-9 pubmed
    ..We mapped the human SRP72 gene to chromosome 18 and, as the CaM kinase II gamma gene was previously mapped to human chromosome 10q22, we suggest this novel cDNA may have resulted from trans-splicing. ..
  60. Stange M, Xu L, Balshaw D, Yamaguchi N, Meissner G. Characterization of recombinant skeletal muscle (Ser-2843) and cardiac muscle (Ser-2809) ryanodine receptor phosphorylation mutants. J Biol Chem. 2003;278:51693-702 pubmed
    ..Taken together, the results did not support the view that phosphorylation of a single site (RyR1-Ser-2843 and RyR2-Ser-2809) substantially changes RyR1 and RyR2 channel function. ..
  61. Si J, Collins S. Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation. Cancer Res. 2008;68:3733-42 pubmed publisher
    ..Thus, CaMKIIgamma is a critical regulator of multiple signaling networks regulating the proliferation of myeloid leukemia cells. Inhibiting CaMKIIgamma may represent a novel approach in the targeted therapy of myeloid leukemia...
  62. Chai S, Xu X, Wang Y, Zhou Y, Zhang C, Yang Y, et al. Ca2+/calmodulin-dependent protein kinase IIγ enhances stem-like traits and tumorigenicity of lung cancer cells. Oncotarget. 2015;6:16069-83 pubmed
    ..Taken together, our findings reveal a critical role of CaMKIIγ in regulating the stemness and tumorigenicity of lung cancer cells and offer a promising therapeutic target for TICs. ..
  63. Johnson L, Willoughby C, Burke S, Paik D, Jenkins K, Tombes R. delta Ca(2+)/Calmodulin-dependent protein kinase II isozyme-specific induction of neurite outgrowth in P19 embryonal carcinoma cells. J Neurochem. 2000;75:2380-91 pubmed
    Ca(2+)/calmodulin-dependent protein kinase II (CaMK-II) has been linked to the induction of differentiation in preneuronal cells...
  64. Oruganti S, Edin S, Grundström C, Grundström T. CaMKII targets Bcl10 in T-cell receptor induced activation of NF-?B. Mol Immunol. 2011;48:1448-60 pubmed publisher
    ..We propose a novel mechanism whereby Ca(2+) signals can be integrated at the immunological synapse through CaMKII-dependent phosphorylation of Bcl10. ..
  65. Anborgh P, Qian X, Papageorge A, Vass W, DeClue J, Lowy D. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol Cell Biol. 1999;19:4611-22 pubmed
  66. Wang D, Shan Y, Huang Y, Tang Y, Chen Y, Li R, et al. Vasostatin-1 Stops Structural Remodeling and Improves Calcium Handling via the eNOS-NO-PKG Pathway in Rat Hearts Subjected to Chronic ?-Adrenergic Receptor Activation. Cardiovasc Drugs Ther. 2016;30:455-464 pubmed
    ..receptors, such as the phosphoinositide-3 kinase (PI3K)/Akt and Ca2+/calmodulin-dependent kinase (CaMK-II) pathways...
  67. Moyers J, Bilan P, Zhu J, Kahn C. Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. J Biol Chem. 1997;272:11832-9 pubmed
    ..Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades. ..
  68. Si J, Mueller L, Collins S. CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells. J Clin Invest. 2007;117:1412-21 pubmed
    ..We observe that CaMKIIgamma is the CaMK that is predominantly expressed in myeloid cells...
  69. Kato K, Sugi T, Takemae H, Takano R, Gong H, Ishiwa A, et al. Characterization of a Toxoplasma gondii calcium calmodulin-dependent protein kinase homolog. Parasit Vectors. 2016;9:405 pubmed publisher
    ..showed that Plasmodium falciparum expresses a homolog of human calcium calmodulin-dependent protein kinase (CaMK) that is important for host cell invasion...
  70. Holmfeldt P, Zhang X, Stenmark S, Walczak C, Gullberg M. CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation. EMBO J. 2005;24:1256-66 pubmed
    ..These two mechanisms, involving CaMKIIgamma and TOGp, respectively, are both essential for spindle bipolarity in a normal physiological context, but not in MCAK-depleted cells. ..
  71. Murungi E, Kariithi H. Genome-Wide Identification and Evolutionary Analysis of Sarcocystis neurona Protein Kinases. Pathogens. 2017;6: pubmed publisher
    ..neurona kinome was devoid of PKB and PKC. Moreover, the kinome contains the six-conserved apicomplexan CDPKs (CAMK group). Several OPK atypical kinases, including ROPKs 19A, 27, 30, 33, 35 and 37 were identified. Notably, S...
  72. Wang J, Guo Y, Zhang X. Design and verification of halogen-bonding system at the complex interface of human fertilization-related MUP PDZ5 domain with CAMK's C-terminal peptide. Comput Biol Chem. 2018;72:164-169 pubmed publisher
    Calmodulin-dependent protein kinase (CAMK) is physiologically activated in fertilized human oocytes and is involved in the Ca2+ response pathways that link the fertilization calmodulin signal to meiosis resumption and cortical ..
  73. Williams C, Phelps S, Porter R. Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in smal. Biochem Pharmacol. 1996;51:707-15 pubmed
    ..The expression of both CaMKII and CaMKIV by SCLC cells, and the sensitivity of these cells to the anti-proliferative effects of KN-62, suggest a role for CaM kinase in regulating SCLC proliferation. ..
  74. Deberry C, Mou S, Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem J. 1997;327 ( Pt 1):73-80 pubmed
    ..These results demonstrate that Stat1 is activated in response to SCF, and suggest that Stat1 is a component of the SCF signal-transduction pathway. ..
  75. Rokolya A, Singer H. Inhibition of CaM kinase II activation and force maintenance by KN-93 in arterial smooth muscle. Am J Physiol Cell Physiol. 2000;278:C537-45 pubmed
    ..Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step...
  76. Gloyn A, Desai M, Clark A, Levy J, Holman R, Frayling T, et al. Human calcium/calmodulin-dependent protein kinase II gamma gene (CAMK2G): cloning, genomic structure and detection of variants in subjects with type II diabetes. Diabetologia. 2002;45:580-3 pubmed
    ..We therefore investigated the gene encoding the gamma isoform ( CAMK2G) which has been shown to be expressed in human beta cells as a candidate gene for Type II (non-insulin-dependent) ..
  77. Salzano M, Rusciano M, Russo E, Bifulco M, Postiglione L, Vitale M. Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation. Cell Cycle. 2012;11:2100-6 pubmed publisher
    ..These results demonstrate that Ras activates CaMKII, which, in turn, phosphorylates Raf-1 at S338 and participates in ERK activation upon different stimuli. ..
  78. Jing Z, Sui X, Yao J, Xie J, Jiang L, Zhou Y, et al. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway. Cancer Lett. 2016;372:226-38 pubmed publisher
  79. Meng Z, Ma X, Du J, Wang X, He M, Gu Y, et al. CAMK2γ antagonizes mTORC1 activation during hepatocarcinogenesis. Oncogene. 2017;36:2446-2456 pubmed publisher
    ..Taken together, our results reveal a novel mechanism by which CAMK2γ antagonizes mTORC1 activation during hepatocarcinogenesis. ..
  80. Nghiem P, Saati S, Martens C, Gardner P, Schulman H. Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues. J Biol Chem. 1993;268:5471-9 pubmed
  81. Kleppe R, Toska K, Haavik J. Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association. J Neurochem. 2001;77:1097-107 pubmed
    ..These findings further support a role for 14-3-3 proteins in the regulation of catecholamine biosynthesis and demonstrate isoform specificity for both TH and 14-3-3 proteins. ..
  82. Dobransky T, Brewer D, Lajoie G, Rylett R. Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42. J Biol Chem. 2003;278:5883-93 pubmed
    ..These studies demonstrate that A beta-(1-42) can acutely regulate the function of choline acetyltransferase, thus potentially altering cholinergic neurotransmission. ..
  83. Lee K, Chen Y, Hsu S, Yu M. Phosphorylation of Serine 235 of the Hepatitis C Virus Non-Structural Protein NS5A by Multiple Kinases. PLoS ONE. 2016;11:e0166763 pubmed publisher
    ..We conclude that CKI?-mediated NS5A S235 phosphorylation is critical for HCV replication. CaMKII ? and ? may have negative roles in the HCV life cycle. ..
  84. Park D, Na M, Kim J, Lee U, Cho E, Jang M, et al. Activation of CaMKIV by soluble amyloid-β1-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis. Sci Signal. 2017;10: pubmed publisher
    ..Neurons derived from a transgenic AD mouse model had similar defects, which were prevented by an inhibitor of CaMK kinase (CaMKK; which activates CaMKIV), by antibodies against Aβ1-42, or by expression a ..
  85. Yuan P, Zheng X, Li M, Ke Y, Fu Y, Zhang Q, et al. Two Sulfur Glycoside Compounds Isolated from Lepidium apetalum Willd Protect NRK52e Cells against Hypertonic-Induced Adhesion and Inflammation by Suppressing the MAPK Signaling Pathway and RAAS. Molecules. 2017;22: pubmed publisher
    ..i>cis-DG and trans-DG, expression of calcineurin (CAN) and Ca/calmodulin-dependent protein kinase II (CaMK II) was decreased in renal tissue and Ca2+ influx was inhibited, thereby reducing the secretion of ..
  86. Wechsler A, Teichberg V. Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin. EMBO J. 1998;17:3931-9 pubmed
    ..The highly regulated linkage of the NMDA-R to spectrin may underlie the morphological changes that occur in neuronal dendrites concurrently with synaptic activity and plasticity. ..
  87. Wu X, McMurray C. Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein. J Biol Chem. 2001;276:1735-41 pubmed
    ..Thus, CamKII confers a dominant inhibitory effect on transcription by preventing dimerization of CREB, and this mechanism may account for the attenuation of gene expression. ..
  88. Wicks S, Lui S, Abdel Wahab N, Mason R, Chantry A. Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol Cell Biol. 2000;20:8103-11 pubmed
    ..These findings provide a novel cross-talk mechanism by which Ca(2+)-dependent kinases activated downstream of multiple growth factor receptors antagonize cell responses to TGF-beta. ..
  89. Tan K, Chan S, Tan K, Yu V. The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. J Biol Chem. 2001;276:44193-202 pubmed
    ..Taken together, our data suggest that hFEM-2 and rCaMKPase are mammalian homologues of FEM-2 and they are evolutionarily conserved CaM kinase phosphatases that may have a role in apoptosis signaling. ..
  90. Meng Z, Li T, Ma X, Wang X, Van Ness C, Gan Y, et al. Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca²?/calmodulin-dependent protein kinase II. Mol Cancer Ther. 2013;12:2067-77 pubmed publisher
    ..Our data suggest that berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII. Mol Cancer Ther; 12(10); 2067-77. ©2013 AACR. ..
  91. Marcelo K, Means A, York B. The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft. Trends Endocrinol Metab. 2016;27:706-718 pubmed publisher
    ..Central to the actions of Ca(2+)/CaM is the activation of a highly conserved Ca(2+)/CaM kinase (CaMK) cascade that amplifies Ca(2+) signals through a series of subsequent phosphorylation events...
  92. Wang Y, Zhao Z, Shi S, Gao F, Wu J, Dong S, et al. Calcium sensing receptor initiating cystathionine-gamma-lyase/hydrogen sulfide pathway to inhibit platelet activation in hyperhomocysteinemia rat. Exp Cell Res. 2017;358:171-181 pubmed publisher
    ..the production of reactive oxygen species (ROS) were measured; the expression of phospho-calmodulin kinases II (p-CaMK II) and Von Willebrand Factor (vWF) of cultured ECs from rat thoracic aortas were measured...