Gene Symbol: CAMK2A
Description: calcium/calmodulin dependent protein kinase II alpha
Alias: CAMKA, MRD53, calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II alpha subunit, CaM-kinase II alpha chain, CaMK-II alpha subunit, CaMKIINalpha, caM kinase II subunit alpha, caMK-II subunit alpha, calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, calcium/calmodulin-dependent protein kinase II alpha-B subunit, calcium/calmodulin-dependent protein kinase type II alpha chain
Species: human
Products:     CAMK2A

Top Publications

  1. Chang B, Mukherji S, Soderling T. Characterization of a calmodulin kinase II inhibitor protein in brain. Proc Natl Acad Sci U S A. 1998;95:10890-5 pubmed
    ..These results characterize a potent and specific cellular inhibitor of CaM-KII that may have an important role in the physiological regulation of this key protein kinase. ..
  2. Gaertner T, Kolodziej S, Wang D, Kobayashi R, Koomen J, Stoops J, et al. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. J Biol Chem. 2004;279:12484-94 pubmed
    ..Simulations utilizing this data revealed that the measured differences in CaM binding affinities play a minor role in the autophosphorylation of the enzyme, which is largely dictated by the rate of autophosphorylation for each isoform. ..
  3. Oh J, Manzerra P, Kennedy M. Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II. J Biol Chem. 2004;279:17980-8 pubmed
    ..We used phosphosite-specific antibodies to show that, as predicted, phosphorylation of serines 765 and 1123 is increased in cultured cortical neurons after exposure of the neurons to the agonist N-methyl-d-aspartate. ..
  4. Bayer K, Lebel E, McDonald G, O Leary H, Schulman H, De Koninck P. Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B. J Neurosci. 2006;26:1164-74 pubmed
    ..This activity-dependent incorporation of CaMKII into postsynaptic sites may play a role in maturation and plasticity of synapses. ..
  5. Wang C, Li N, Liu X, Zheng Y, Cao X. A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. J Biol Chem. 2008;283:11565-74 pubmed publisher
  6. Djakovic S, Schwarz L, Barylko B, Demartino G, Patrick G. Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase II. J Biol Chem. 2009;284:26655-65 pubmed publisher
    ..Our data provide a novel mechanism whereby CaMKII may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation. ..
  7. Bingol B, Wang C, Arnott D, Cheng D, Peng J, Sheng M. Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines. Cell. 2010;140:567-78 pubmed publisher
    ..Our findings reveal a scaffolding role of postsynaptic CaMKIIalpha in activity-dependent proteasome redistribution, which is commensurate with the great abundance of CaMKIIalpha in synapses. ..
  8. Moyers J, Bilan P, Zhu J, Kahn C. Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. J Biol Chem. 1997;272:11832-9 pubmed
    ..Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades. ..
  9. Giese K, Fedorov N, Filipkowski R, Silva A. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science. 1998;279:870-3 pubmed
    ..Thus, the autophosphorylation of alphaCaMKII at Thr286 appears to be required for LTP and learning. ..

More Information

Publications181 found, 100 shown here

  1. Elgersma Y, Fedorov N, Ikonen S, Choi E, Elgersma M, Carvalho O, et al. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 2002;36:493-505 pubmed
    ..Mimicking inhibitory phosphorylation dramatically decreased the association of CaMKII with the PSD and blocked both LTP and learning. These data demonstrate that inhibitory phosphorylation has a critical role in plasticity and learning. ..
  2. Yuan K, Chung L, Siegal G, Zayzafoon M. alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression. Lab Invest. 2007;87:938-50 pubmed
    ..Our results suggest that CaMKII plays a critical role in the growth of osteosarcoma, and its inhibition could be an attractive therapeutic target to combat conventional high-grade osteosarcoma in children. ..
  3. Lee R, Brown B, Lolley R. Protein kinase A phosphorylates retinal phosducin on serine 73 in situ. J Biol Chem. 1990;265:15860-6 pubmed
    ..These observations are uniformly in agreement with protein kinase A being the endogenous kinase that phosphorylates phosducin in vivo. ..
  4. Kourrich S, Klug J, Mayford M, Thomas M. AMPAR-independent effect of striatal ?CaMKII promotes the sensitization of cocaine reward. J Neurosci. 2012;32:6578-86 pubmed publisher
    ..This study identifies CaMKII regulation of IA in NAc shell neurons as a novel cellular contributor to the sensitization of cocaine reward. ..
  5. Silva J, Qin H, Cowell J. Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice. Genesis. 2019;57:e23268 pubmed publisher
    ..In contrast, targeting inactivation of LGI1 in cells expressing Gfap, Camk2a, and parvalbumin, did not lead to cortical dysplasia...
  6. El Haou S, Balse E, Neyroud N, Dilanian G, Gavillet B, Abriel H, et al. Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. Circ Res. 2009;104:758-69 pubmed publisher
    ..In conclusion, SAP97 is a major partner for surface expression and CaMKII-dependent regulation of cardiac Kv4 channels. ..
  7. Toyofuku T, Curotto Kurzydlowski K, Narayanan N, MacLennan D. Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase. J Biol Chem. 1994;269:26492-6 pubmed
    ..Thus phosphorylation of Ser38 in SERCA2 results in a unique activation of Vmax for Ca2+ transport, providing a potential regulatory mechanism for Ca2+ removal from cardiac and other tissues in which SERCA2 is expressed. ..
  8. Jaffe H, Vinade L, Dosemeci A. Identification of novel phosphorylation sites on postsynaptic density proteins. Biochem Biophys Res Commun. 2004;321:210-8 pubmed
    ..Phosphorylated serine residues in several of the identified phosphorylation sites were followed by prolines, suggesting prominent involvement of proline directed kinases in the regulation of PSD components. ..
  9. Snowball A, Chabrol E, Wykes R, Shekh Ahmad T, Cornford J, Lieb A, et al. Epilepsy Gene Therapy Using an Engineered Potassium Channel. J Neurosci. 2019;39:3159-3169 pubmed publisher
    ..EKC) gene was packaged into a nonintegrating lentiviral vector under the control of a cell type-specific CAMK2A promoter...
  10. Tokui T, Yamauchi T, Yano T, Nishi Y, Kusagawa M, Yatani R, et al. Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteins. Biochem Biophys Res Commun. 1990;169:896-904 pubmed
    ..The actions of Ca2(+)-CaM-dependent protein kinase II on non-epithelial intermediate filaments under physiological conditions are given attention. ..
  11. Ohta Y, Ohba T, Miyamoto E. Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cells. Proc Natl Acad Sci U S A. 1990;87:5341-5 pubmed
    ..The localization of CaM kinase II in the cell nucleus and the mitotic apparatus suggests that the enzyme may play a role in the cell cycle progression of mammalian cells. ..
  12. Duan S, Yao Z, Hou D, Wu Z, Zhu W, Wu M. Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J. 2007;26:3062-74 pubmed
    ..Together, our data suggest that phosphorylation of Pirh2 may act as a fine-tuning to maintain the balance of p53-Pirh2 autoregulatory feedback loop, which facilitates the tight regulation of p53 stability and tumor suppression. ..
  13. Huang T, Nguyen L, Lin T, Gong X, Zhang L, Kim G, et al. In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neurosci Res. 2018;: pubmed publisher
    ..g., Tbr1, Dcx) or increase (e.g., Eno2, Camk2a, Syn1) as neurons mature...
  14. Wegner M, Cao Z, Rosenfeld M. Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta. Science. 1992;256:370-3 pubmed
    ..Phosphorylation of serine at position 276 within the leucine zipper of C/EBP beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP beta. ..
  15. Inagaki M, Gonda Y, Nishizawa K, Kitamura S, Sato C, Ando S, et al. Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domain. J Biol Chem. 1990;265:4722-9 pubmed
    ..All the sites are located within the amino-terminal non-alpha-helical head domain of GFAP. These observations pave the way for in vivo studies on organization of glial filaments. ..
  16. Gee K, Angel J, Mishra S, Blahoianu M, Kumar A. IL-10 regulation by HIV-Tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factors. J Immunol. 2007;178:798-807 pubmed
    ..Taken together, our results suggest that extracellular HIV-Tat induced IL-10 transcription in primary human monocytes is regulated by CREB-1 and Sp-1 transcription factors through the activation of calmodulin/CaMK-II-dependent p38 MAPK. ..
  17. Raveendran R, Devi Suma Priya S, Mayadevi M, Steephan M, Santhoshkumar T, Cheriyan J, et al. Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II. J Neurochem. 2009;110:92-105 pubmed publisher
    ..We also show for the first time that phosphatases in the brain such as protein phosphatase 1 and protein phosphatase 2A dephosphorylate phospho-Ser1303 on NR2B. ..
  18. Hellmuth S, Böttger F, Pan C, Mann M, Stemmann O. PP2A delays APC/C-dependent degradation of separase-associated but not free securin. EMBO J. 2014;33:1134-47 pubmed publisher
  19. Otake K, Kamiguchi H, Hirozane Y. Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. BMC Med Genomics. 2019;12:7 pubmed publisher
    ..which 4580 genes were commonly detected among four individuals, including neuron-enriched genes such as TUBB3 and CAMK2A. In comparison with exosomal mRNAs in CSF from four patients with amyotrophic lateral sclerosis, 543 genes were ..
  20. Dobransky T, Brewer D, Lajoie G, Rylett R. Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42. J Biol Chem. 2003;278:5883-93 pubmed
    ..These studies demonstrate that A beta-(1-42) can acutely regulate the function of choline acetyltransferase, thus potentially altering cholinergic neurotransmission. ..
  21. Liu A, Wong Y. Activation of nuclear factor {kappa}B by somatostatin type 2 receptor in pancreatic acinar AR42J cells involves G{alpha}14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src. J Biol Chem. 2005;280:34617-25 pubmed
    ..Similar results were also obtained using AR42J cells. These data suggest that activation of the IKK/NFkappaB signaling cascade by SSTR2 requires a complicated network consisting of Galpha(14) and multiple intermediates. ..
  22. Fuchsova B, Alvarez Juliá A, Rizavi H, Frasch A, Pandey G. Altered expression of neuroplasticity-related genes in the brain of depressed suicides. Neuroscience. 2015;299:1-17 pubmed publisher
    ..The expression level of calcium/calmodulin-dependent protein kinase II alpha (CAMK2A) and coronin1A (CORO1A) was also significantly decreased...
  23. Walker A, Tripathy K, Restrepo C, Ge G, Xu Y, Kwong L, et al. An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Hum Mol Genet. 2015;24:7241-54 pubmed publisher
    ..Here, we developed transgenic (Tg) mice with forebrain Camk2a-controlled doxycycline-suppressible expression of a TDP-43 CTF (amino acids 208-414, designated 208 TDP-43 CTF), ..
  24. Sheriff S, F Qureshy A, T Chance W, Kasckow J, Balasubramaniam A. Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]. Peptides. 2002;23:87-96 pubmed
    ..These findings suggest that the NPY Y(1) receptor induces the expression of CRE containing target genes through the CaM kinase-CREB pathway, and inhibits CRE containing genes when cellular cAMP levels are elevated. ..
  25. Thein S, Tao Cheng J, Li Y, Bayer K, Reese T, Dosemeci A. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. PLoS ONE. 2014;9:e91312 pubmed publisher
  26. Vincent M, Geneviève D, Ostertag A, Marlin S, Lacombe D, Martin Coignard D, et al. Treacher Collins syndrome: a clinical and molecular study based on a large series of patients. Genet Med. 2016;18:49-56 pubmed publisher
    ..identified four patients carrying a mutation in EFTUD2 and two patients with 5q32 deletion encompassing TCOF1 and CAMK2A in particular...
  27. Kuzniewska B, Chojnacka M, Milek J, Dziembowska M. Preparation of polysomal fractions from mouse brain synaptoneurosomes and analysis of polysomal-bound mRNAs. J Neurosci Methods. 2018;293:226-233 pubmed publisher
    ..with Existing Methods We fractionated polyribosomes from synaptoneurosomes and detected the association of Mmp9, Camk2a and Stx1B mRNA with polysomes in the unstimulated conditions...
  28. Gardoni F, Bellone C, Cattabeni F, Di Luca M. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. J Biol Chem. 2001;276:7609-13 pubmed
    ..Thus, our data provide clues on understanding the molecular basis of a direct cross-talk between alphaCaMKII and PKC pathways in the postsynaptic compartment. ..
  29. Robison A, Bass M, Jiao Y, MacMillan L, Carmody L, Bartlett R, et al. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J Biol Chem. 2005;280:35329-36 pubmed
  30. Bourguignon L, Gilad E, Brightman A, Diedrich F, Singleton P. Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells. J Biol Chem. 2006;281:14026-40 pubmed
  31. Chen Y, Yang C, Wang Z. Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia. J Neurosci. 2010;30:38-46 pubmed publisher
    ..These data implicate, for the first time, an essential role of CaMKIIalpha as a cellular mechanism leading to and maintaining opioid-induced hyperalgesia...
  32. Achterberg K, Buitendijk G, Kool M, Goorden S, Post L, Slump D, et al. Temporal and region-specific requirements of αCaMKII in spatial and contextual learning. J Neurosci. 2014;34:11180-7 pubmed publisher
    ..Germline deletion of Camk2a leads to severe deficits in spatial and contextual learning in mice...
  33. Yang J, Hou Z, Wang C, Wang H, Zhang H. Gene expression profiles reveal key genes for early diagnosis and treatment of adamantinomatous craniopharyngioma. Cancer Gene Ther. 2018;25:227-239 pubmed publisher
    ..of CDH1, CCL2, ITGA2, COL8A1, COL6A2, and COL6A3 were significantly upregulated in ACP tumor samples, while CAMK2A, RIMS1, NEFL, SYT1, and STX1A were significantly downregulated, which were consistent with the differentially ..
  34. Seeger C, Talibov V, Danielson U. Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+ /calmodulin-dependent kinase II. J Mol Recognit. 2017;30: pubmed publisher
    ..The data for full-length Ng, but not Ng27-50 , agree with the current model on Ng regulation of Ca2+/CaM signaling. ..
  35. Rha J, Jones S, Fidler J, Banerjee A, Leung S, Morris K, et al. The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice. Hum Mol Genet. 2017;26:3663-3681 pubmed publisher
    ..Among the proteins increased in the hippocampi of Zc3h14Δex13/Δex13 mice compared to control are key synaptic proteins including CaMK2a. This newly generated mouse serves as a tool to study the function of ZC3H14 in vivo.
  36. Bouvard D, Block M. Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha. Biochem Biophys Res Commun. 1998;252:46-50 pubmed
    ..Conversely, the mutation T38A produces an analog of ICAP-1alpha that cannot be phosphorylated and that stimulates cell spreading on fibronectin to a similar extent when CaMKII is inhibited. ..
  37. Correia S, Bassani S, Brown T, Lise M, Backos D, El Husseini A, et al. Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. Nat Neurosci. 2008;11:457-66 pubmed publisher
    ..In summary, we identified the specific motor protein and organelle acceptor that catalyze the directional transport of AMPARs into spines during activity-dependent synaptic plasticity. ..
  38. Saiyed Z, Gandhi N, Agudelo M, Napuri J, Samikkannu T, Reddy P, et al. HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND). Neurochem Int. 2011;58:656-64 pubmed publisher
    ..Therefore, use of HDAC2 specific inhibitor in combination with HAART may be of therapeutic value in treatment of neurocognitive disorders observed in HIV-1 infected individuals. ..
  39. Mang G, Pradervand S, Du N, Arpat A, Preitner F, Wigger L, et al. A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice. PLoS ONE. 2015;10:e0116760 pubmed publisher
    ..b>Camk2a-CreERT2 (Cre+) and floxed Dicer (Dicerlox/lox) mice were crossed to generate tamoxifen-inducible conditional Dicer ..
  40. Maussion G, Moalic J, Simonneau M, Gorwood P, Ramoz N. Increased expression of BDNF mRNA in the frontal cortex of autistic patients. Behav Brain Res. 2019;359:903-909 pubmed publisher
    ..on a candidate genes approach, we present in this study the expression data of 4 transcripts of interest (BDNF, CAMK2a, NR-CAM and RIMS1) located at the synapse in two regions of interest in the context of the ASDs; the lobule VI of ..
  41. Countaway J, Nairn A, Davis R. Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase. J Biol Chem. 1992;267:1129-40 pubmed
    ..This regulatory phosphorylation site is located at the carboxyl terminus of the EGF receptor within the subdomain that binds src homology 2 regions of signaling molecules. ..
  42. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill M, Engel K, et al. MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo. J Biol Chem. 1999;274:14434-43 pubmed
    ..These results demonstrate that SRF is targeted by several signal transduction pathways within cells and establishes SRF as a nuclear target for MAPKAP kinase 2. ..
  43. Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, et al. Regulation of neuronal nitric-oxide synthase by calmodulin kinases. J Biol Chem. 1999;274:20597-602 pubmed
    ..Using the antibody NP847, we obtained evidence that nNOS is phosphorylated at Ser847 in rat brain. Thus, our results suggest that CaM kinase-induced phosphorylation of nNOS at Ser847 alters the activity control of this enzyme. ..
  44. Fluck M, Booth F, Waxham M. Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites. Biochem Biophys Res Commun. 2000;270:488-94 pubmed
    ..The location of Thr-160 in the 3-D structure of SRF suggests that its phosphorylation by nuclear CaMKII may directly influence DNA binding of SRF and other MADS box factors. ..
  45. Yamamoto H. [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]. Tanpakushitsu Kakusan Koso. 2002;47:241-7 pubmed
  46. Virdee K, Yoshida H, Peak Chew S, Goedert M. Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily. FEBS Lett. 2007;581:2657-62 pubmed
    ..MSK1 phosphorylated S214, as well as S262, a KXGS site in the first repeat, and S305 in the second repeat. ..
  47. Kong L, Wang B, Yuan R, Jia M, Wang K. [Expression and clinical significance of the genes of Wnt signaling pathway in keratocystic odontogenic tumor of the jaw bones]. Shanghai Kou Qiang Yi Xue. 2015;24:89-93 pubmed
    ..Compared to normal oral mucosa, there were 5 genes of Wnt signaling pathway in KCOT changed, including CAMK2A down-regulated, FZD3, MAPK10, PRKX and WNT5a up-regulated...
  48. Meyers J, Salling M, Almli L, Ratanatharathorn A, Uddin M, Galea S, et al. Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways. Transl Psychiatry. 2015;5:e586 pubmed publisher
    ..variants across the mGluR-eEF2-AMPAR pathway (including GRM1, GRM5, HOMER1, HOMER2, EEF2K, MTOR, EIF4E, EEF2, CAMK2A, ARC, GRIA1 and GRIA4) were found to predict number of drinking days per month (corrected P-value < 0...
  49. Isensee J, Schild C, Schwede F, Hucho T. Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. J Cell Sci. 2017;130:2134-2146 pubmed publisher the signaling components protein kinase A (PKA)-RIIβ (also known as PRKAR2B) and CaMKIIα (also known as CAMK2A) developed at around postnatal day 10, the time of nociceptor maturation...
  50. Nehme R, Zuccaro E, Ghosh S, Li C, Sherwood J, Pietiläinen O, et al. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 2018;23:2509-2523 pubmed publisher
    ..The most differentiated neurons could be identified using a CAMK2A::GFP reporter gene and exhibited greater functionality, including NMDAR-mediated synaptic transmission...
  51. Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M. Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein. J Biol Chem. 1996;271:17957-60 pubmed
    ..As expected from these in vitro studies, transient transfection studies revealed that ATF1 is activated by CaMK II. Our findings suggest that CaMK II mediates transactivation of cAMP responsive genes via ATF1. ..
  52. Sessoms Sikes S, Honse Y, Lovinger D, Colbran R. CaMKIIalpha enhances the desensitization of NR2B-containing NMDA receptors by an autophosphorylation-dependent mechanism. Mol Cell Neurosci. 2005;29:139-47 pubmed
    ..These data suggest a novel mechanism for Ca2+-dependent negative-feedback regulation of NR2B-containing NMDARs in a CaMKII activity- and autophosphorylation-dependent manner that may modulate NMDAR-mediated synaptic plasticity. ..
  53. Novak G, Seeman P, Tallerico T. Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression. Synapse. 2006;59:61-8 pubmed
    ..Because CaMKIIbeta influences the expression of many neuroreceptors and influences neural outgrowth and pruning, its altered expression in the cerebral cortex in schizophrenia or depression may contribute to these diseases. ..
  54. Rellos P, Pike A, Niesen F, Salah E, Lee W, von Delft F, et al. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 2010;8:e1000426 pubmed publisher
    ..Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the Web plugin are available in Text S1. ..
  55. Li Q, Zhang Y, Sheng Y, Huo R, Sun B, Teng X, et al. Large T-antigen up-regulates Kv4.3 K? channels through Sp1, and Kv4.3 K? channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II. Biochem J. 2012;441:859-67 pubmed publisher
    ..3 K? channels contribute to cell apoptosis and necrosis through activating CaMKII. The present study provides deep insights into the mechanism of the regulation of Kv4.3 K? channels and the role of Kv4.3 K? channels in cell death. ..
  56. Doroudi M, Plaisance M, Boyan B, Schwartz Z. Membrane actions of 1α,25(OH)2D3 are mediated by Ca(2+)/calmodulin-dependent protein kinase II in bone and cartilage cells. J Steroid Biochem Mol Biol. 2015;145:65-74 pubmed publisher
    ..b>Camk2a-silenced but not Camk2b-silenced osteoblasts showed comparable effects...
  57. Cao M, Wu J. Camk2a-Cre-mediated conditional deletion of chromatin remodeler Brg1 causes perinatal hydrocephalus. Neurosci Lett. 2015;597:71-6 pubmed publisher
    ..We discovered an unexpected early activity of mouse Camk2a-Cre transgene, which mediates Brg1 deletion in a subset of forebrain neurons beginning in the late embryonic stage...
  58. Zhang Y, Han Z, Sun Y. Structure-based identification of CaMKIIα-interacting MUPP1 PDZ domains and rational design of peptide ligands to target such interaction in human fertilization. Amino Acids. 2016;48:1509-21 pubmed publisher
    ..Other five designed peptides (SILPSV(-COOH), SGLPNV(-COOH), SIVMSV(-COOH), SIVPNV(-COOH) and SIAMNV(-COOH)) possessed comparable affinity with the wild type, and they may be further optimized to obtain higher potency. ..
  59. Lee J, Lee L, Fan C, Chang H, Shih H, Min M, et al. Important roles of Vilse in dendritic architecture and synaptic plasticity. Sci Rep. 2017;7:45646 pubmed publisher
    ..Changes in dendritic complexity and spine density were noticed in hippocampal neurons of Camk2a-Cre mediated forebrain-specific Vilse knockout (VilseΔ/Δ) mice...
  60. Mito M, Kadota M, Tanaka K, Furuta Y, Abe K, Iwasaki S, et al. Cell Type-Specific Survey of Epigenetic Modifications by Tandem Chromatin Immunoprecipitation Sequencing. Sci Rep. 2018;8:1143 pubmed publisher
    ..FLAG-tagged histone H2B, a constitutive chromatin component, was first expressed in Camk2a-positive pyramidal cortical neurons and used to purify chromatin in a cell type-specific manner...
  61. Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong C, et al. Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Autophagy. 2016;12:1340-54 pubmed publisher
    ..In summary, our data clearly demonstrate that oxidative stress activates the TRPM2-Ca(2+)-CAMK2 cascade to phosphorylate BECN1 resulting in autophagy inhibition. ..
  62. Lin C, Kapiloff M, Durgerian S, Tatemoto K, Russo A, Hanson P, et al. Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. Proc Natl Acad Sci U S A. 1987;84:5962-6 pubmed
    ..The domain organization suggests a structural model for calcium/calmodulin-dependent and independent states that might subserve short- and long-term responses to transient stimuli. ..
  63. Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt Ulms G, Meyer H, et al. Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. J Biol Chem. 1995;270:7679-88 pubmed
    ..The data suggest a role for this novel kinase in cellular events involving rearrangement of the microtuble-associated proteins/microtubule arrays and their pathological degeneration in Alzheimer's disease. ..
  64. Omkumar R, Kiely M, Rosenstein A, Min K, Kennedy M. Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem. 1996;271:31670-8 pubmed
    ..We show that serine 1303 in the full-length NR2B and/or the cognate site in NR2A is a major site of phosphorylation of the receptor both in the postsynaptic density fraction and in living hippocampal neurons. ..
  65. Hanger D, Betts J, Loviny T, Blackstock W, Anderton B. New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J Neurochem. 1998;71:2465-76 pubmed
    ..We identified 22 phosphorylation sites in PHF-tau, including five sites not previously identified. The combination of our new data with previous reports shows that PHF-tau can be phosphorylated on at least 25 different sites. ..
  66. Liao G, Wagner D, Hsu M, Leonard J. Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current. Mol Pharmacol. 2001;59:960-4 pubmed
    ..The direct action of PKC on certain NMDA receptor subtypes may be important in any physiological or pathological process where PKC and NR2B/NR1 receptors interact. ..
  67. Tan K, Chan S, Tan K, Yu V. The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. J Biol Chem. 2001;276:44193-202 pubmed
    ..Taken together, our data suggest that hFEM-2 and rCaMKPase are mammalian homologues of FEM-2 and they are evolutionarily conserved CaM kinase phosphatases that may have a role in apoptosis signaling. ..
  68. Wang L, Bai J, Hu Y. Identification of the RA response element and transcriptional silencer in human alphaCaMKII promoter. Mol Biol Rep. 2008;35:37-44 pubmed
    ..Further analysis showed that there were two RA response elements located between +11 and +136 and -1911 to -593. In addition, we have identified a potent silencer at position -179 to -244 of the human alphaCaMKII promoter. ..
  69. Ament S, Szelinger S, Glusman G, Ashworth J, Hou L, Akula N, et al. Rare variants in neuronal excitability genes influence risk for bipolar disorder. Proc Natl Acad Sci U S A. 2015;112:3576-81 pubmed publisher
    ..3,014 cases and 1,717 controls confirmed rare variant associations in ANK3, CACNA1B, CACNA1C, CACNA1D, CACNG2, CAMK2A, and NGF...
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  71. Arguello T, Moraes C. Cre recombinase activity is inhibited in vivo but not ex vivo by a mutation in the asymmetric spacer region of the distal loxP site. Genesis. 2015;53:695-700 pubmed publisher
    ..and cre transgene under the control of tissue-specific promoters: calcium/calmodulin-dependent kinase II alpha (Camk2a-cre) and myosin light polypeptide 1 (Myl1-cre)...
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    ..cell populations: noradrenergic neurons of the compact, bilateral locus coeruleus and two dispersed populations, Camk2a+ neurons and GFAP+ glia...
  73. Chiocchetti A, Yousaf A, Bour H, Haslinger D, Waltes R, Duketis E, et al. Common functional variants of the glutamatergic system in Autism spectrum disorder with high and low intellectual abilities. J Neural Transm (Vienna). 2018;125:259-271 pubmed publisher
    ..At the phenotypic level, we nominally replicated associations of CAMK2A-rs2241694 with non-verbal communication in both combined LIQ and HIQ ASD cohorts...
  74. Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, et al. Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Biochem J. 2003;372:465-71 pubmed
    ..Thus PSD-95 mediates cellular trafficking of nNOS, and may be required for the efficient phosphorylation of nNOS at Ser(847) by CaM-K II in neuronal cells. ..
  75. Wollmuth L, Kuner T, Sakmann B. Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+. J Physiol. 1998;506 ( Pt 1):13-32 pubmed
    ..The contribution to the blocking site, in contrast to the prevailing view, is stronger for the N + 1 site than for the N-site asparagine. The block may involve binding of Mg2+ to these residues. ..
  76. Poggi A, Carosio R, Spaggiari G, Fortis C, Tambussi G, Dell Antonio G, et al. NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domain. J Immunol. 2002;168:95-101 pubmed
    ..These data provide evidence that exogenous Tat inhibits NK cell activation occurring upon contact with DC: this mechanism might contribute to the impairment of natural immunity in HIV-1 infection. ..
  77. Dhavan R, Greer P, Morabito M, Orlando L, Tsai L. The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. J Neurosci. 2002;22:7879-91 pubmed
  78. Simats A, García Berrocoso T, Ramiro L, Giralt D, Gill N, Penalba A, et al. Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology. Sci Rep. 2018;8:7899 pubmed publisher
    ..Seven promising candidates were further evaluated in rat plasma and brain (CKB, CaMK2A, CaMK2B, CaMK2D, PDXP, AREG, CMPK)...
  79. Williams C, Phelps S, Porter R. Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in smal. Biochem Pharmacol. 1996;51:707-15 pubmed
    ..The expression of both CaMKII and CaMKIV by SCLC cells, and the sensitivity of these cells to the anti-proliferative effects of KN-62, suggest a role for CaM kinase in regulating SCLC proliferation. ..
  80. Li W, Okano A, Tian Q, Nakayama K, Furihata T, Nawa H, et al. Characterization of a novel synGAP isoform, synGAP-beta. J Biol Chem. 2001;276:21417-24 pubmed
    ..The beta isoform did not interact with PSD-95 but specifically interacted with a nonphosphorylated alpha subunit of Ca(2+)/calmodulin-dependent protein kinase II through its unique C-terminal tail. ..
  81. Tatsuki F, Sunagawa G, Shi S, Susaki E, Yukinaga H, Perrin D, et al. Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals. Neuron. 2016;90:70-85 pubmed publisher
    ..Kcnn2 and Kcnn3), voltage-gated Ca(2+) channels (Cacna1g and Cacna1h), or Ca(2+)/calmodulin-dependent kinases (Camk2a and Camk2b) decrease sleep duration, while impaired plasma membrane Ca(2+) ATPase (Atp2b3) increases sleep ..
  82. Chao L, Stratton M, Lee I, Rosenberg O, Levitz J, Mandell D, et al. A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell. 2011;146:732-45 pubmed publisher
    ..This equilibrium between autoinhibited states provides a simple mechanism for tuning the calcium response without changes in either the hub or the kinase domains. ..
  83. Hoffman A, Carpenter H, Kahl R, Watt L, Dickson P, Rostas J, et al. Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition. Cell Signal. 2014;26:748-56 pubmed publisher
    ..Taken together, these results strongly suggest that the dephosphorylation of CaMKII at T253 is involved in controlling the cell cycle, specifically the metaphase-anaphase transition. ..
  84. Chia P, Zhong F, Niwa S, Bonnard C, Utami K, Zeng R, et al. A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability. elife. 2018;7: pubmed publisher
    ..1-q34 and is caused by a biallelic germline mutation in CAMK2A. The missense mutation, p...
  85. Wang Y, Chen G, Hu X, Lu Y, Zhou J, Liu R. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. Brain Res. 2005;1031:101-8 pubmed
    ..Since the co-localization of CaMKII-alpha with hyperphosphorylated tau is relatively rare, we concluded that CaMKII-alpha may be related with beta-amyloid more closely than being involved in tau hyperphosphorylation. ..
  86. Jian X, Wang K, Wu T, Hillhouse J, Mullersman J. Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies. J Abnorm Child Psychol. 2011;39:773-82 pubmed publisher
    ..00036) and CAMK2A (rs2053053, p=0.00098)...
  87. Li C, Li L, Lin B, Fang Y, Yang H, Liu H, et al. Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells. Environ Toxicol. 2017;32:1784-1791 pubmed publisher
    ..we have validated the toxicity of TDCIPP in PC12 cells owing to the induced alterations in GAP43, NF-H, CaMK2a/2b, and tubulin ?/? proteins; however, limited information is currently available on the toxicity and mechanism of ..
  88. Omary M, Baxter G, Chou C, Riopel C, Lin W, Strulovici B. PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18. J Cell Biol. 1992;117:583-93 pubmed
    ..We propose that a kinase related to the catalytic fragment of PKC epsilon physically associates with and phosphorylates cytokeratins 8 and 18. ..
  89. Suzuki T, Li W, Zhang J, Tian Q, Sakagami H, Usuda N, et al. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. Eur J Neurosci. 2005;21:339-50 pubmed
    ..These results suggest that TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins. ..
  90. Fleming I, Fisslthaler B, Dimmeler S, Kemp B, Busse R. Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res. 2001;88:E68-75 pubmed
    ..Moreover, the dephosphorylation of Thr(495) by PP1 precedes the phosphorylation of Ser(1177) by CaMKII. The full text of this article is available at ..
  91. Walikonis R, Oguni A, Khorosheva E, Jeng C, Asuncion F, Kennedy M. Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin. J Neurosci. 2001;21:423-33 pubmed
  92. Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, et al. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain. 2008;1:6 pubmed publisher
    ..Based on these results, we propose that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders. ..