Gene Symbol: CAMK1
Description: calcium/calmodulin dependent protein kinase I
Alias: CAMKI, calcium/calmodulin-dependent protein kinase type 1, caM kinase I alpha, caM-KI, caMKI-alpha
Species: human
Products:     CAMK1

Top Publications

  1. Qin H, Raught B, Sonenberg N, Goldstein E, Edelman A. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. J Biol Chem. 2003;278:48570-9 pubmed
    b>CaMKI is a Ca2+/calmodulin-dependent protein kinase that is widely expressed in eukaryotic cells and tissues but for which few, if any, physiological substrates are known...
  2. Yokokura H, Picciotto M, Nairn A, Hidaka H. The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains. J Biol Chem. 1995;270:23851-9 pubmed
    ..2 microM) but was non-competitive with ATP. Thus, these results suggest that CaM kinase I is regulated through an intrasteric mechanism common to other members of the family of Ca2+/CaM-dependent protein kinases. ..
  3. Haribabu B, Hook S, Selbert M, Goldstein E, Tomhave E, Edelman A, et al. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. EMBO J. 1995;14:3679-86 pubmed
    Human Ca(2+)-calmodulin (CaM) dependent protein kinase I (CaMKI) encodes a 370 amino acid protein with a calculated M(r) of 41,337. The 1...
  4. Chang C, Chang G, Chen H. A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion. Mol Cell Biol. 2011;31:3820-31 pubmed publisher
    ..We show that Epac1 and Rap1, in response to cAMP, activate CaMKI to phosphorylate Ser47 in GCM1...
  5. Saneyoshi T, Wayman G, Fortin D, Davare M, Hoshi N, Nozaki N, et al. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron. 2008;57:94-107 pubmed publisher
    ..pathway downstream of the NMDA receptor that stimulates calmodulin-dependent kinase kinase (CaMKK) and CaMKI to promote formation of spines and synapses in hippocampal neurons...
  6. Matsushita M, Nairn A. Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. J Biol Chem. 1998;273:21473-81 pubmed
    Ca2+/calmodulin-dependent protein kinase I (CaMKI) is maintained in an autoinhibited state by the interaction of a COOH-terminal helix-loop-helix (Ile286-Met316) regulatory domain with the catalytic core...
  7. Uboha N, Flajolet M, Nairn A, Picciotto M. A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth. J Neurosci. 2007;27:4413-23 pubmed
    ..Calcium- and calmodulin-dependent kinase I (CaMKI) can regulate neurite outgrowth; however, the signal transduction cascades that lead to its physiological effects ..
  8. Clapperton J, Martin S, Smerdon S, Gamblin S, Bayley P. Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism. Biochemistry. 2002;41:14669-79 pubmed
    Calcium-saturated calmodulin (CaM) directly activates CaM-dependent protein kinase I (CaMKI) by binding to a region in the C-terminal regulatory sequence of the enzyme to relieve autoinhibition...
  9. Takata T, Tsukuda A, Tsuchiya Y, Akaike T, Watanabe Y. The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation. Nitric Oxide. 2019;: pubmed publisher
    ..Here, we report that the activity of CaMKI was reversibly inhibited via its polysulfidation at Cys179 by RSS...

More Information


  1. Takabatake S, Ohtsuka S, Sugawara T, Hatano N, Kanayama N, Magari M, et al. Regulation of Ca2+/calmodulin-dependent protein kinase kinase β by cAMP signaling. Biochim Biophys Acta Gen Subj. 2019;1863:672-680 pubmed publisher
    Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) is a pivotal activator of CaMKI, CaMKIV and 5'-AMP-activated protein kinase (AMPK), controlling Ca2+-dependent intracellular signaling including various ..
  2. Ardiel E, McDiarmid T, Timbers T, Lee K, Safaei J, Pelech S, et al. Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in Caenorhabditis elegans. Proc Biol Sci. 2018;285: pubmed publisher
    ..We show that the Caenorhabditis elegans orthologues of Ca2+/calmodulin-dependent kinases CaMK1/4, CMK-1 and O-linked N-acetylglucosamine (O-GlcNAc) transferase, OGT-1, both function in primary sensory neurons ..
  3. Kukimoto Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, et al. Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011;286:22570-9 pubmed publisher
    ..CaMKK phosphorylates and activates CaMKI and CaMKIV, which directly activate transcription factors. In this study, we determined the 2...
  4. Shao H, Ma L, Jin F, Zhou Y, Tao M, Teng Y. Immune inhibitory receptor LILRB2 is critical for the endometrial cancer progression. Biochem Biophys Res Commun. 2018;506:243-250 pubmed publisher
    ..Mechanistically, LILRB2 enhances the SHP2/CaMK1/CREB signaling pathways to support the expansion and migration of the endometrial cancer cells...
  5. Santiago A, Couñago R, Ramos P, Godoi P, Massirer K, Gileadi O, et al. Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors. Sci Rep. 2018;8:14800 pubmed publisher
    The calcium/calmodulin-dependent protein kinases (CAMKKs) are upstream activators of CAMK1 and CAMK4 signalling and have important functions in neural development, maintenance and signalling, as well as in other aspects of biology such ..
  6. Yu Y, Bell H, Glauser D, Van Hooser S, Goodman M, Sengupta P. CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron. Neuron. 2014;84:919-926 pubmed publisher
    ..These temperature-regulated changes in gene expression are mediated by the CMK-1 CaMKI enzyme, which exhibits T(c)-dependent nucleocytoplasmic shuttling in AFD...
  7. Yadlapalli S, Wani K, Xu X. Past experience resets behavior: CaMK takes the heat. Neuron. 2014;84:883-5 pubmed publisher
    ..2014) dissected the molecular mechanisms underlying experience-dependent plasticity in thermosensory behavior. They show that Ca(2+)/calmodulin-dependent kinase I (CaMKI) regulates thermal preferences according to past experience.
  8. Saito A, Miyajima K, Akatsuka J, Kondo H, Mashiko T, Kiuchi T, et al. CaMKII?-mediated LIM-kinase activation plays a crucial role in BDNF-induced neuritogenesis. Genes Cells. 2013;18:533-43 pubmed publisher
    ..CaMKK activity is required for the activation of CaMKI and CaMKIV, but not CaMKII, which suggests that CaMKII is principally involved in BDNF-induced enhancement of ..
  9. Shulman Y, Stavsky A, Fedorova T, Mikulincer D, Atias M, Radinsky I, et al. ATP binding to synaspsin IIa regulates usage and clustering of vesicles in terminals of hippocampal neurons. J Neurosci. 2015;35:985-98 pubmed publisher
    ..Finally, we found that the K270Q mutation attenuated the phosphorylation of synapsin IIa on a distant PKA/CaMKI consensus site known to be essential for vesicle recruitment...
  10. Kang X, Lu Z, Cui C, Deng M, Fan Y, Dong B, et al. The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development. Nat Cell Biol. 2015;17:665-77 pubmed publisher
    ..LAIR1 induces activation of SHP-1, which acts as a phosphatase-independent signalling adaptor to recruit CAMK1 for activation of downstream CREB in AML cells...
  11. Schild L, Zbinden L, Bell H, Yu Y, Sengupta P, Goodman M, et al. The balance between cytoplasmic and nuclear CaM kinase-1 signaling controls the operating range of noxious heat avoidance. Neuron. 2014;84:983-96 pubmed publisher
    ..Here, we identify a gain-of-function allele of the cmk-1 CaMKI gene in C...
  12. Takemoto Kimura S, Suzuki K, Horigane S, Kamijo S, Inoue M, Sakamoto M, et al. Calmodulin kinases: essential regulators in health and disease. J Neurochem. 2017;141:808-818 pubmed publisher
    ..The most investigated CaMKs for these roles in neuronal functions are CaMKI, CaMKII, CaMKIV and we will shed light on these neuronal CaMKs' functions in this review...
  13. Senga Y, Ishida A, Shigeri Y, Kameshita I, Sueyoshi N. The Phosphatase-Resistant Isoform of CaMKI, Ca²⁺/Calmodulin-Dependent Protein Kinase Iδ (CaMKIδ), Remains in Its "Primed" Form without Ca²⁺ Stimulation. Biochemistry. 2015;54:3617-30 pubmed publisher
    Ca²⁺/calmodulin-dependent protein kinase I (CaMKI) is known to play pivotal roles in Ca²⁺ signaling pathways. Four isoforms of CaMKI (α, β, γ, and δ) have been reported so far...
  14. Lomas Soria C, Pérez Ramírez I, Caballero Pérez J, Guevara Gonzalez R, Guevara Olvera L, Loarca Piña G, et al. Cooked common beans (Phaseolus vulgaris L.) modulate renal genes in streptozotocin-induced diabetic rats. J Nutr Biochem. 2015;26:761-8 pubmed publisher
    ..using expressed sequence tag, consumption of cooked beans improved the expression of Glu1, Cps1, Ipmk, Cacna1c, Camk1, Pdhb, Ptbp3 and Pim1, which are related to the elimination of ammonium groups, the regulation of inflammatory and ..
  15. Lim J, Fehlauer H, Das A, Sarò G, Glauser D, Brunet A, et al. Loss of CaMKI Function Disrupts Salt Aversive Learning in C. elegans. J Neurosci. 2018;38:6114-6129 pubmed publisher
    ..Here, we show that the sole worm ortholog of mammalian CaMKI/IV, CMK-1, is essential for salt-aversive learning behavior in C. elegans hermaphrodites...
  16. Qin F, Cao H, Yuan H, Guo W, Pei H, Cao Y, et al. 1800 MHz radiofrequency fields inhibits testosterone production via CaMKI /RORα pathway. Reprod Toxicol. 2018;81:229-236 pubmed publisher
    ..Star, P450scc, P450c17 and 3β-Hsd) in testicular tissue, (iii) significantly reduced regulatory protein CaMKI/RORα. Similar observations were also made in cultured primary Leydig cells exposed in vitro to RF...
  17. Kylarova S, Psenakova K, Herman P, Obsilova V, Obsil T. CaMKK2 kinase domain interacts with the autoinhibitory region through the N-terminal lobe including the RP insert. Biochim Biophys Acta Gen Subj. 2018;1862:2304-2313 pubmed publisher
    ..member of the Ca⁠2+/calmodulin-dependent kinase (CaMK) family, functions as an upstream activator of CaMKI, CaMKIV and AMP-activated protein kinase...
  18. Liu X, Yu X, Xie J, Zhan M, Yu Z, Xie L, et al. ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells. Oncotarget. 2015;6:21004-15 pubmed
    ..analyses indicated that ANGPTL2 binds LILRB2 to support the growth of lung cancer cells and that the SHP2/CaMK1/CREB axis controls the proliferation of lung cancer cell lines...
  19. Lee H, Itahana Y, Schuechner S, Fukuda M, Je H, Ogris E, et al. Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis. Sci Signal. 2018;11: pubmed publisher
    ..3 (CACNA1D), followed by activation of the kinase CAMK1. CAMK1 and the demethylase PPME1 were required for the subsequent demethylation and inactivation of the catalytic ..
  20. Mitsuhashi K, Senmaru T, Fukuda T, Yamazaki M, Shinomiya K, Ueno M, et al. Testosterone stimulates glucose uptake and GLUT4 translocation through LKB1/AMPK signaling in 3T3-L1 adipocytes. Endocrine. 2016;51:174-84 pubmed publisher
    ..Activation of GLUT4 translocation-related protein kinases, including Akt, AMPK, LKB1, CaMKI, CaMKII, and Cbl was followed by immunoblotting...
  21. Cohen S, Li B, Tsien R, Ma H. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015;460:88-99 pubmed publisher
    ..the CaMK family is made up of only three members, and CREB phosphorylation is mediated by CMK-1, the homologue of CaMKI. CMK-1 nuclear translocation directly regulates adaptation of thermotaxis behavior in response to changes in the ..
  22. Zhang X, Yuan D, Sun Q, Xu L, Lee E, Lewis A, et al. Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis. FASEB J. 2017;31:4382-4395 pubmed publisher
    ..pharmacologic depolarization or LPS leads to Ca2+-dependent mitochondrial recruitment and activation of CaMKI that precedes the colocalization of PINK1/Parkin and DJ-1...
  23. Kang X, Cui C, Wang C, Wu G, Chen H, Lu Z, et al. CAMKs support development of acute myeloid leukemia. J Hematol Oncol. 2018;11:30 pubmed publisher
    ..Knockdown of CAMKI or CAMKIV decreased human acute leukemia development in vitro and in vivo...
  24. Neal S, Takeishi A, O Donnell M, Park J, Hong M, Butcher R, et al. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. elife. 2015;4: pubmed publisher
    ..In this study, we show that CMK-1 CaMKI regulates the dauer decision as a function of feeding state...
  25. Abdou H, Robert N, Tremblay J. Calcium-dependent Nr4a1 expression in mouse Leydig cells requires distinct AP1/CRE and MEF2 elements. J Mol Endocrinol. 2016;56:151-61 pubmed publisher LH stimulation leads to a rapid and robust activation of Nr4a1 gene expression that requires the Ca(2+)/CAMKI pathway. However, the downstream transcription factor(s) have yet to be characterized...
  26. Amano M, Hamaguchi T, Shohag M, Kozawa K, Kato K, Zhang X, et al. Kinase-interacting substrate screening is a novel method to identify kinase substrates. J Cell Biol. 2015;209:895-912 pubmed publisher
    ..The KISS method was also applied to additional kinases, including PKA, MAPK1, CDK5, CaMK1, PAK7, PKN, LYN, and FYN, and a lot of candidate substrates and their phosphorylation sites were determined, most ..
  27. Zhang Y, Qiao L, Xu W, Wang X, Li H, Xu W, et al. Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway. Molecules. 2017;22: pubmed publisher
    ..we attempted to confirm the hypothesis that its protection effect is via the modulation of the Ca2+/CaMKI)/CREB signaling pathway...
  28. Kobayashi K, Nakano S, Amano M, Tsuboi D, Nishioka T, Ikeda S, et al. Single-Cell Memory Regulates a Neural Circuit for Sensory Behavior. Cell Rep. 2016;14:11-21 pubmed publisher
    ..the single-cell memory exhibits inter-individual variability, which is controlled by the evolutionarily conserved CaMKI/IV and Raf pathway...
  29. Onouchi T, Kishino Kaneko Y, Kameshita I, Ishida A, Sueyoshi N. Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) by protocadherin-γC5 (Pcdh-γC5). Arch Biochem Biophys. 2015;585:109-120 pubmed publisher
    ..Dephosphorylation of phosphorylated Ca(2+)/calmodulin-dependent protein kinase I (CaMKI) by CaMKP was significantly activated by the C-terminal cytoplasmic fragment, Pcdh-γC5(715-944), both in vitro ..
  30. Sung U, Binda F, Savchenko V, Owens W, Daws L. Ca2+ dependent surface trafficking of norepinephrine transporters depends on threonine 30 and Ca2+ calmodulin kinases. J Chem Neuroanat. 2017;83-84:19-35 pubmed publisher
    ..A proteomic analysis, RNA interference, and pharmacological inhibition supported roles of CaMKI and CaMKII in Ca2+-modulated NE transport and NET trafficking...
  31. Psenakova K, Petrvalska O, Kylarova S, Lentini Santo D, Kalabova D, Herman P, et al. 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim Biophys Acta Gen Subj. 2018;1862:1612-1625 pubmed publisher
    ..This upstream activator of CaMKI, CaMKIV and AMP-activated protein kinase is inhibited by phosphorylation, which also triggers an association with ..
  32. Nguyen T, Combarnous Y, Praud C, Duittoz A, Blesbois E. Ca2+/Calmodulin-Dependent Protein Kinase Kinases (CaMKKs) Effects on AMP-Activated Protein Kinase (AMPK) Regulation of Chicken Sperm Functions. PLoS ONE. 2016;11:e0147559 pubmed publisher
    ..The presence of CaMKKs and their substrates CaMKI and CaMKIV was evaluated by western-blotting and indirect immunofluorescence...
  33. Hosaka M, Hammer R, Sudhof T. A phospho-switch controls the dynamic association of synapsins with synaptic vesicles. Neuron. 1999;24:377-87 pubmed
    ..The dynamic association of synapsins with synaptic vesicles correlates with their role in activity-dependent plasticity. ..
  34. Lee C, Yang F, Chang H, Chou H, Tan B, Lee S. Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1. J Biol Chem. 2014;289:21108-19 pubmed
    ..the SIK2-PP2A holoenzyme complex dephosphorylates and inactivates Ca2(+)/calmodulin-dependent protein kinase I (CaMKI), an upstream kinase for phosphorylating PME-1/Ser(15)...
  35. Condon J, Pezzi V, Drummond B, Yin S, Rainey W. Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. Endocrinology. 2002;143:3651-7 pubmed
    ..To determine which CaMK regulates CYP11B2, vectors containing the complete coding sequences for CaMKI, CaMKII, and CaMKIV were transfected with the CYP11B2 reporter construct...
  36. Song T, Hatano N, Horii M, Tokumitsu H, Yamaguchi F, Tokuda M, et al. Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation. FEBS Lett. 2004;570:133-7 pubmed
    ..These results raise the possibility of a novel cross-talk between nNOS and CaM-K I through the phosphorylation of Ser741 on nNOS. ..
  37. Monteiro P, Gilot D, Le Ferrec E, Rauch C, Lagadic Gossmann D, Fardel O. Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. Mol Pharmacol. 2008;73:769-77 pubmed
    ..Taken together, these data identified the Ca(2+)/CaM/CaMKIalpha pathway as an important contributing factor to AhR-mediated genomic response. ..
  38. Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, et al. Regulation of neuronal nitric-oxide synthase by calmodulin kinases. J Biol Chem. 1999;274:20597-602 pubmed
    ..Using the antibody NP847, we obtained evidence that nNOS is phosphorylated at Ser847 in rat brain. Thus, our results suggest that CaM kinase-induced phosphorylation of nNOS at Ser847 alters the activity control of this enzyme. ..
  39. Backs J, Song K, Bezprozvannaya S, Chang S, Olson E. CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest. 2006;116:1853-64 pubmed
    ..These findings reveal a central role for HDAC4 in CaMKII signaling pathways and have implications for the control of gene expression by calcium signaling in a variety of cell types. ..
  40. Li X, Song S, Liu Y, Ko S, Kao H. Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins. J Biol Chem. 2004;279:34201-8 pubmed
    ..Together, our results suggest that calcium/calmodulin-dependent kinase I-mediated phosphorylation of HDAC7 acts, in part, to promote association of HDAC7 with 14-3-3 and stabilizes HDAC7. ..
  41. Chang T, Chen M, Chang J, Huang H, Ho W, Lin Y, et al. Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy. PLoS ONE. 2016;11:e0166791 pubmed publisher
    ..Therefore, 5 NFAT associated genes (PPP3R1, PPP3CB, CAMK1, MEF2C, PLCE1) were studies for validation...
  42. Le Hellard S, Håvik B, Espeseth T, Breilid H, Løvlie R, Luciano M, et al. Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities. PLoS ONE. 2009;4:e7534 pubmed publisher
    ..These data present DCLK1 as a functionally pertinent gene involved in human memory and cognitive functions. ..
  43. Chun H, Hao W, Honghai Z, Ning L, Yasong W, Chen D. CCL3L1 prevents gp120-induced neuron death via the CREB cell signaling pathway. Brain Res. 2009;1257:75-88 pubmed publisher
    ..with CCL3L1 plus gp120; (ii) CCL3L1 induces cell survival via phosphorylation of CREB by way of the PKA and CaMKI/CaMKIV cell signaling pathways; (iii) transcription of the cell survival gene bcl-2 is induced by pCREB; and (iv) ..
  44. McKinsey T, Zhang C, Lu J, Olson E. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408:106-11 pubmed
  45. Matsushita M, Nairn A. Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. J Biol Chem. 1999;274:10086-93 pubmed
    Several recent studies have shown that Ca2+/calmodulin-dependent protein kinase I (CaMKI) is phosphorylated and activated by a protein kinase (CaMKK) that is itself subject to regulation by Ca2+/calmodulin...
  46. Chen Y, Chen H, Tseng W, Hsu J, Huang T, Chen C, et al. A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling. Dev Cell. 2016;39:209-223 pubmed publisher
    ..Here we show that CRH-1/CREB activation by CMK-1/CaMKI in the AFD thermosensory neuron is a key mechanism that maintains lifespan at warm temperatures in C. elegans...
  47. Senga Y, Akizuki K, Katayama S, Shigeri Y, Kameshita I, Ishida A, et al. High-performance CaMKI: A highly active and stable form of CaMKI? produced by high-level soluble expression in Escherichia coli. Biochem Biophys Res Commun. 2016;475:277-82 pubmed publisher
    ..Unlike the corresponding fragment of CaMKI? (CaMK??(1-294)), the kinase activity of zCaMKI?(1-299), without activation procedures, was comparable to that of ..
  48. Anderson K, Means R, Huang Q, Kemp B, Goldstein E, Selbert M, et al. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. J Biol Chem. 1998;273:31880-9 pubmed
    Ca2+/calmodulin-dependent protein kinases I and IV (CaMKI and CaMKIV, respectively) require phosphorylation on an equivalent single Thr in the activation loop of subdomain VIII for maximal activity...
  49. Ekokoski E, Aitio O, Törnquist K, Yli Kauhaluoma J, Tuominen R. HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition. Eur J Pharm Sci. 2010;40:404-11 pubmed publisher
    ..showed inhibitory activity at least towards other AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1)...
  50. Chang C, Cheong M, Chang G, Tsai M, Chen H. Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion. Mol Hum Reprod. 2013;19:745-55 pubmed publisher
    ..cAMP enhances GCM1 desumoylation through the Epac1/Rap1/CaMKI signaling cascade and CaMKI is known to down-regulate class IIa HDAC activity...
  51. Wang L, Huang J, Jiang M, Chen Q, Jiang Z, Feng H. CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation. Cell Biochem Biophys. 2014;70:1011-6 pubmed publisher
    We data-analyzed and constructed the high-expression CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) compared with low-expression (fold change ? 2) no-tumor hepatitis/..
  52. Hsu L, Tsou A, Chi C, Lee C, Chen J. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. J Biomed Sci. 1998;5:141-9 pubmed
    ..The CaMKK gene is localized to human chromosome 12. The presence of cDNA clones with divergent 3' terminal sequences suggests a family of CaMKK variants which may arise from alternative splicing. ..
  53. Sackmann S, Lichtenauer U, Shapiro I, Reincke M, Beuschlein F. Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways. Horm Metab Res. 2011;43:106-11 pubmed publisher
    ..Along the same line, CaMKI was significantly upregulated in APAs on the mRNA and protein level...
  54. Chin D, Winkler K, Means A. Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. J Biol Chem. 1997;272:31235-40 pubmed
    Calcium/calmodulin (CaM) directly activates CaM-dependent protein kinase I (CaMKI) by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of CaMKI by an exogenous kinase...
  55. Liu F, Thompson M, Wagner S, Greenberg M, Green M. Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation. J Biol Chem. 1993;268:6714-20 pubmed
    ..Taken together, these results suggest a mechanism that allows cells to integrate and differentiate gene regulation by cAMP and Ca2+. ..
  56. Kahl C, Means A. Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. J Biol Chem. 2004;279:15411-9 pubmed
    ..To determine which multifunctional CaMK acts in G(1), we expressed kinase-deficient forms of CaMKI and CaMKII...
  57. Ishikawa Y, Tokumitsu H, Inuzuka H, Murata Hori M, Hosoya H, Kobayashi R. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. FEBS Lett. 2003;550:57-63 pubmed
    ..This sustained activation of CaM-KIdelta was completely abolished by Thr180Ala mutation and inhibited by CaM-KK inhibitor, STO-609, indicating a functional CaM-KK/CaM-KIdelta cascade in HeLa cells. ..
  58. Sakurada K, Kato H, Nagumo H, Hiraoka H, Furuya K, Ikuhara T, et al. Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. J Biol Chem. 2002;277:45473-9 pubmed
    ..These results raise the possibility that Ser(603) on synapsin I is alternatively phosphorylated by PAKs, not only by CaMKII, in neuronal cells in response to some stimulants. ..
  59. Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, et al. Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Biochem J. 2003;372:465-71 pubmed
    ..Thus PSD-95 mediates cellular trafficking of nNOS, and may be required for the efficient phosphorylation of nNOS at Ser(847) by CaM-K II in neuronal cells. ..
  60. Komeima K, Hayashi Y, Naito Y, Watanabe Y. Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. J Biol Chem. 2000;275:28139-43 pubmed
    ..Thus, our results indicate that Ca(2+) triggers cross-talk signal transduction between CaM kinase and NO and CaM-K IIalpha phosphorylating nNOS on Ser(847), which in turn decreases the gaseous second messenger NO in neuronal cells. ..
  61. Bredt D, Ferris C, Snyder S. Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. J Biol Chem. 1992;267:10976-81 pubmed
    ..We demonstrate that purified NOS is labeled by a photoaffinity derivative of calmodulin. These recognition sites on NOS provide multiple means for regulation of NO levels and "cross-talk" between second messenger systems. ..
  62. Riascos D, Nicholas A, Samaeekia R, Yukhananov R, Mesulam M, Bigio E, et al. Alterations of Ca²?-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. Neurobiol Aging. 2014;35:1325-33 pubmed publisher RNA and protein for CB and the Ca(2+)-responsive proteins Ca(2+)/calmodulin-dependent protein kinase I (CaMKI), growth-associated protein-43 (GAP43), and calpain in the BF...
  63. York B, Li F, Lin F, Marcelo K, Mao J, Dean A, et al. Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Sci Rep. 2017;7:11793 pubmed publisher
    ..kinase kinase 2) is a central member of this kinase family as it controls the actions of a CaMK cascade involving CaMKI, CaMKIV or AMPK...
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    Human calcium/calmodulin-dependent protein kinase I (CaMKI) plays pivotal roles in the nervous system. The activity of human CaMKI is regulated by a regulatory region including an autoinhibitory segment and a CaM-binding segment...
  66. Gu Y, Qi B, Zhou Y, Jiang X, Zhang X, Li X, et al. Porcine Circovirus Type 2 Activates CaMMK? to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium. Viruses. 2016;8: pubmed publisher
    ..CaMKK? then activated both AMPK and calcium/calmodulin-dependent protein kinase I (CaMKI)...
  67. Hsu L, Chen G, Lee L, Chi C, Cheng J, Chen J. Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. J Biol Chem. 2001;276:31113-23 pubmed
    ..The differential expression of CaMKK beta isoforms with distinct activity further suggests the complexity of the regulation of the CaMKK/CaMK cascade and an important role for CaMKK in the action of Ca(+2)-mediated cellular responses. ..
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    ..Our studies suggest that 14-3-3 binding to HDAC5 is required for CaMK-dependent disruption of MEF2-HDAC complexes and nuclear export of HDAC5, and implicate 14-3-3 as a signal-dependent regulator of muscle cell differentiation. ..
  69. Ishida A, Tada Y, Nimura T, Sueyoshi N, Katoh T, Takeuchi M, et al. Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain: biochemical analysis of the interaction. Arch Biochem Biophys. 2005;435:134-46 pubmed
    ..Further, anti-CaMKP antibody coimmunoprecipitated GAPDH in a rat brain extract. GAPDH was phosphorylated by CaMKI or CaMKIV in vitro; however, when CaMKP coexisted, the phosphorylation was markedly attenuated...
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    ..the receptor-interacting serine/threonine kinase 2 (RIPK2) and calcium/calmodulin-dependent protein kinase 1α (CAMK1α)...
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    ..Ca(2+)/CaM-dependent kinase 1 (CaMKI) appears critical in regulating the assembly of the cyclin D1/cdk4 complex essential for G1 progression, but how ..