calreticulin

Summary

Gene Symbol: calreticulin
Description: calreticulin
Alias: CRT, HEL-S-99n, SSA, cC1qR, calreticulin, CRP55, ERp60, HACBP, Sicca syndrome antigen A (autoantigen Ro; calreticulin), calregulin, endoplasmic reticulum resident protein 60, epididymis secretory sperm binding protein Li 99n, grp60
Species: human
Products:     calreticulin

Top Publications

  1. Gray A, Park P, Broekelmann T, Laurent G, Reeves J, Stenmark K, et al. The mitogenic effects of the B beta chain of fibrinogen are mediated through cell surface calreticulin. J Biol Chem. 1995;270:26602-6 pubmed
    ..Sequence analysis of the amino terminus of this protein indicated 100% homology to human calreticulin. Immunoprecipitation experiments employing a polyclonal anti-calreticulin antibody provided further evidence ..
  2. Eggleton P, Lieu T, Zappi E, Sastry K, Coburn J, Zaner K, et al. Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein. Clin Immunol Immunopathol. 1994;72:405-9 pubmed
    The Ca2+ storage protein calreticulin is associated with the endoplasmic reticulum and shares a high degree of amino acid homology with the surface receptor C1q-R...
  3. Iwaki H, Kageyama S, Isono T, Wakabayashi Y, Okada Y, Yoshimura K, et al. Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma -synuclein, and catechol-o-methyltransferase) identified by proteomic analysis. Cancer Sci. 2004;95:955-61 pubmed
    Using proteomic analysis, we previously identified calreticulin (CRT) as a potentially useful urinary marker for bladder cancer...
  4. Roderick H, Campbell A, Llewellyn D. Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors. FEBS Lett. 1997;405:181-5 pubmed
    The multi-functional protein calreticulin (CRT) is normally found within the lumen of the endoplasmic reticulum (ER). However, some of its proposed functions require it to be located within the nucleus, where its presence is contentious...
  5. Klampfl T, Gisslinger H, Harutyunyan A, Nivarthi H, Rumi E, Milosevic J, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369:2379-90 pubmed publisher
    ..Resequencing of CALR, encoding calreticulin, was then performed in cohorts of patients with myeloid neoplasms...
  6. Clark R, Li S, Pearson D, Leidal K, Clark J, Denning G, et al. Regulation of calreticulin expression during induction of differentiation in human myeloid cells. Evidence for remodeling of the endoplasmic reticulum. J Biol Chem. 2002;277:32369-78 pubmed
    Induction of differentiation of HL-60 human myeloid cells profoundly affected expression of calreticulin, a Ca(2+)-binding endoplasmic reticulum chaperone...
  7. Tarr J, Winyard P, Ryan B, Harries L, Haigh R, Viner N, et al. Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells. Arthritis Rheum. 2010;62:2919-29 pubmed publisher
    ..Thus, the present study was undertaken to determine which factors might inhibit FasL-Fas binding in vivo and those that would inhibit apoptosis of T lymphocytes in an in vitro model system...
  8. Rizvi S, Mancino L, Thammavongsa V, Cantley R, Raghavan M. A polypeptide binding conformation of calreticulin is induced by heat shock, calcium depletion, or by deletion of the C-terminal acidic region. Mol Cell. 2004;15:913-23 pubmed
    It is widely believed that the chaperone activity of calreticulin is mediated by its ability to bind glycoproteins containing monoglucosylated oligosaccharides. However, calreticulin is also a polypeptide binding protein...
  9. Nørgaard Toft K, Larsen N, Steen Jørgensen F, Højrup P, Houen G, Vestergaard B. Small angle X-ray scattering study of calreticulin reveals conformational plasticity. Biochim Biophys Acta. 2008;1784:1265-70 pubmed publisher
    b>Calreticulin plays a central role in vital cell processes such as protein folding, Ca(2+) homeostasis and immunogenicity. Even so, only limited three-dimensional structural information is presently available...

More Information

Publications72

  1. Peng R, Chen Y, Ding Y, Zhang R, Zhang X, Yu X, et al. Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer. World J Gastroenterol. 2010;16:2428-34 pubmed
    To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage IIIB colon cancer...
  2. Johnson R, Xiao G, Shanmugaratnam J, Fine R. Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein. Neurobiol Aging. 2001;22:387-95 pubmed
    ..Since chaperone molecules such as calreticulin (Crt) have been shown to be important in the maturation of many glycoproteins, we investigated the interaction ..
  3. Tarr J, Young P, Morse R, Shaw D, Haigh R, Petrov P, et al. A mechanism of release of calreticulin from cells during apoptosis. J Mol Biol. 2010;401:799-812 pubmed publisher
    b>Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone responsible for glycoprotein folding and Ca(2+) homeostasis. CRT also has extracellular functions, e.g...
  4. Hisaoka M, Matsuyama A, Nakamoto M. Aberrant calreticulin expression is involved in the dedifferentiation of dedifferentiated liposarcoma. Am J Pathol. 2012;180:2076-83 pubmed publisher
    ..several unique genes that were highly expressed in dedifferentiated liposarcoma, and the gene encoding calreticulin (CALR), a major Ca(2+)-buffering protein that can inhibit adipocyte differentiation, was found to be ..
  5. Vera C, Tapia V, Kohan K, Gabler F, Ferreira A, Selman A, et al. Nerve growth factor induces the expression of chaperone protein calreticulin in human epithelial ovarian cells. Horm Metab Res. 2012;44:639-43 pubmed publisher
    ..b>Calreticulin is a multifunctional protein with anti-angiogenic properties and its translocation to the tumor cell membrane ..
  6. Andrin C, Pinkoski M, Burns K, Atkinson E, Krahenbuhl O, Hudig D, et al. Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules. Biochemistry. 1998;37:10386-94 pubmed
    b>Calreticulin is a component of cytotoxic T-lymphocyte and NK lymphocyte granules...
  7. Rumi E, Pietra D, Ferretti V, Klampfl T, Harutyunyan A, Milosevic J, et al. JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes. Blood. 2014;123:1544-51 pubmed publisher
    Patients with essential thrombocythemia may carry JAK2 (V617F), an MPL substitution, or a calreticulin gene (CALR) mutation...
  8. Rotunno G, Mannarelli C, Guglielmelli P, Pacilli A, Pancrazzi A, Pieri L, et al. Impact of calreticulin mutations on clinical and hematological phenotype and outcome in essential thrombocythemia. Blood. 2014;123:1552-5 pubmed publisher
    Mutations in the calreticulin (CALR) gene were recently discovered in patients with essential thrombocythemia (ET) lacking the JAK2V617F and MPLW515 mutations, but no information is available on the clinical correlates...
  9. Qiu Y, Michalak M. Transcriptional control of the calreticulin gene in health and disease. Int J Biochem Cell Biol. 2009;41:531-8 pubmed publisher
    b>Calreticulin is a multifunctional Ca(2+) binding chaperone in the endoplasmic reticulum and expression of the protein is tightly regulated at the transcriptional level...
  10. Vannucchi A, Rotunno G, Bartalucci N, Raugei G, Carrai V, Balliu M, et al. Calreticulin mutation-specific immunostaining in myeloproliferative neoplasms: pathogenetic insight and diagnostic value. Leukemia. 2014;28:1811-8 pubmed publisher
    Mutations in the gene calreticulin (CALR) occur in the majority of JAK2- and MPL-unmutated patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF); identifying CALR mutations contributes to the diagnostic pathway of ..
  11. Conway E, Liu L, Nowakowski B, Steiner Mosonyi M, Ribeiro S, Michalak M. Heat shock-sensitive expression of calreticulin. In vitro and in vivo up-regulation. J Biol Chem. 1995;270:17011-6 pubmed
    b>Calreticulin (CRT) is an ubiquitous, highly conserved, Ca(2+)-binding protein of the sarcoplasmic and endoplasmic reticulum. The precise function(s) of CRT is unknown...
  12. Dedhar S, Rennie P, Shago M, Hagesteijn C, Yang H, Filmus J, et al. Inhibition of nuclear hormone receptor activity by calreticulin. Nature. 1994;367:480-3 pubmed
    ..shown that a polypeptide of M(r) 60,000 (60K) that shares N-terminal homology with a calcium-binding protein, calreticulin, can bind to an amino-acid sequence motif, KXGFFKR, found in the cytoplasmic domains of all integrin alpha-..
  13. Allen S, Bulleid N. Calnexin and calreticulin bind to enzymically active tissue-type plasminogen activator during biosynthesis and are not required for folding to the native conformation. Biochem J. 1997;328 ( Pt 1):113-9 pubmed
    The roles of the endoplasmic-reticulum lectins calnexin and calreticulin in the folding of tissue-type plasminogen activator (tPA) have been investigated using an in vitro translation system that reconstitutes these processes as they ..
  14. Goicoechea S, Pallero M, Eggleton P, Michalak M, Murphy Ullrich J. The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem. 2002;277:37219-28 pubmed
    ..adhesions through binding of amino acids (aa) 17-35 (hep I peptide) of thrombospondin to a cell surface form of calreticulin (CRT)...
  15. Arnaudeau S, Frieden M, Nakamura K, Castelbou C, Michalak M, Demaurex N. Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria. J Biol Chem. 2002;277:46696-705 pubmed
    To study the role of calreticulin in Ca(2+) homeostasis and apoptosis, we generated cells inducible for full-length or truncated calreticulin and measured Ca(2+) signals within the cytosol, the endoplasmic reticulum (ER), and mitochondria ..
  16. Elton C, Smethurst P, Eggleton P, Farndale R. Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets. Thromb Haemost. 2002;88:648-54 pubmed
    b>Calreticulin is an abundant protein in the endoplasmic reticulum of most cells...
  17. Tefferi A, Guglielmelli P, Lasho T, Rotunno G, Finke C, Mannarelli C, et al. CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: an international study of 570 patients. Leukemia. 2014;28:1494-500 pubmed publisher
    ..We recently reported DIPSS-plus independent prognostic significance for calreticulin (CALR) (favorable) and ASXL1 (unfavorable) mutations...
  18. Hodge J, Garnett C, Farsaci B, Palena C, Tsang K, Ferrone S, et al. Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death. Int J Cancer. 2013;133:624-36 pubmed publisher
    ..However, calreticulin (CRT) exposure was observed in all cell lines examined after chemotherapy treatment...
  19. Alur M, Nguyen M, Eggener S, Jiang F, Dadras S, Stern J, et al. Suppressive roles of calreticulin in prostate cancer growth and metastasis. Am J Pathol. 2009;175:882-90 pubmed publisher
    b>Calreticulin is an essential, multifunctional Ca(2+)-binding protein that participates in the regulation of intracellular Ca(2+) homeostasis, cell adhesion, and chaperoning...
  20. Duus K, Hansen P, Houen G. Interaction of calreticulin with amyloid beta peptide 1-42. Protein Pept Lett. 2008;15:103-7 pubmed
    The interaction of calreticulin with amyloid beta (Abeta) was investigated using solid phase and solution binding assays. Calreticulin bound Abeta 1-42 in a time and concentration dependent fashion...
  21. Gelebart P, Opas M, Michalak M. Calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum. Int J Biochem Cell Biol. 2005;37:260-6 pubmed
    b>Calreticulin is a 46-kDa Ca2+-binding chaperone found across a diverse range of species. The protein is involved in the regulation of intracellular Ca2+ homeostasis and endoplasmic reticulum (ER) Ca2+ storage capacity...
  22. Burns K, Duggan B, Atkinson E, Famulski K, Nemer M, Bleackley R, et al. Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature. 1994;367:476-80 pubmed
    b>Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation...
  23. Rumi E, Harutyunyan A, Pietra D, Milosevic J, Casetti I, Bellini M, et al. CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis. Blood. 2014;123:2416-9 pubmed publisher
    Somatic mutations in the calreticulin (CALR) gene were recently discovered in patients with sporadic essential thrombocythemia (ET) and primary myelofibrosis (PMF) lacking JAK2 and MPL mutations...
  24. Tefferi A, Lasho T, Finke C, Knudson R, Ketterling R, Hanson C, et al. CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons. Leukemia. 2014;28:1472-7 pubmed publisher
    b>Calreticulin (CALR) mutations were recently described in JAK2 and MPL unmutated primary myelofibrosis (PMF) and essential thrombocythemia...
  25. Cheng S, Nguyen T, Yang Y, Capra J, Sontheimer R. Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen. J Immunol. 1996;156:4484-91 pubmed
    b>Calreticulin (CR) is a multifunctional, calcium-binding protein that has recently been shown to bind to and promote the replication of the rubella virus genome in mammalian cells...
  26. Erickson R, Dunning L, Olson D, Cohen S, Davis A, Wood W, et al. In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind beta-amyloid. Biochem Biophys Res Commun. 2005;332:50-7 pubmed
    ..fluid (CSF) from normals, we find that the bulk of the abetas are bound to the ER chaperones, ERp57 and calreticulin, suggesting that these may be carrier proteins which prevent aggregation of the abetas and that the deposits ..
  27. Zimmerman K, Graham L, Pallero M, Murphy Ullrich J. Calreticulin regulates transforming growth factor-?-stimulated extracellular matrix production. J Biol Chem. 2013;288:14584-98 pubmed publisher
    ..b>Calreticulin (CRT) is an ER chaperone and regulator of Ca(2+) signaling up-regulated by ER stress and in fibrotic tissues...
  28. Oliver J, Roderick H, Llewellyn D, High S. ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin. Mol Biol Cell. 1999;10:2573-82 pubmed
    ..In this study we demonstrate that ERp57 forms discrete complexes with the ER lectins, calnexin and calreticulin. Specific ERp57/calreticulin complexes exist in canine pancreatic microsomes, as demonstrated by SDS-PAGE after ..
  29. Gao B, Adhikari R, Howarth M, Nakamura K, Gold M, Hill A, et al. Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity. 2002;16:99-109 pubmed
    MHC class I molecules expressed in a calreticulin-deficient cell line (K42) assembled with beta 2-microglobulin (beta2-m) normally, but their subsequent loading with optimal peptides was defective...
  30. Bernard Marissal N, Moumen A, Sunyach C, Pellegrino C, Dudley K, Henderson C, et al. Reduced calreticulin levels link endoplasmic reticulum stress and Fas-triggered cell death in motoneurons vulnerable to ALS. J Neurosci. 2012;32:4901-12 pubmed publisher
    ..We show that Fas activation leads, specifically in mSOD1 motoneurons, to reductions in levels of calreticulin (CRT), a calcium-binding ER chaperone...
  31. Li B, Xu J, Wang J, Gale R, Xu Z, Cui Y, et al. Calreticulin mutations in Chinese with primary myelofibrosis. Haematologica. 2014;99:1697-700 pubmed publisher
    ..These data underscore the need to evaluate the prognostic impact of genetic mutations in different populations...
  32. Kang S, Cresswell P. Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. J Biol Chem. 2002;277:44838-44 pubmed
    ..Here we show that CD1d associates in the ER with both calnexin and calreticulin and with the thiol oxidoreductase ERp57 in a manner dependent on glucose trimming of its N-linked glycans...
  33. Li S, Forslöw A, Sundqvist K. Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction. J Immunol. 2005;174:654-61 pubmed
    ..We show in this study that the thrombospondin-1 binding site of calreticulin, spanning aa 19-32, is a major triggering factor for T cell motility and migration within a three-dimensional ..
  34. Lwin Z, Guo C, Salim A, Yip G, Chew F, Nan J, et al. Clinicopathological significance of calreticulin in breast invasive ductal carcinoma. Mod Pathol. 2010;23:1559-66 pubmed publisher
    b>Calreticulin is a chaperone protein located in the lumen of the endoplasmic reticulum. The association of calreticulin with pathological conditions such as autoimmune disorders and certain types of cancer have been reported...
  35. Arosa F, de Jesus O, Porto G, Carmo A, de Sousa M. Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. J Biol Chem. 1999;274:16917-22 pubmed
    b>Calreticulin is an endoplasmic reticulum resident molecule known to be involved in the folding and assembly of major histocompatibility complex (MHC) class I molecules...
  36. Nangalia J, Massie C, Baxter E, Nice F, Gundem G, Wedge D, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369:2391-2405 pubmed publisher
    ..The mutation status of the gene encoding calreticulin (CALR) was assessed in an additional 1345 hematologic cancers, 1517 other cancers, and 550 controls...
  37. Kobayashi S, Uchiyama S, Sone T, Noda M, Lin L, Mizuno H, et al. Calreticulin as a new histone binding protein in mitotic chromosomes. Cytogenet Genome Res. 2006;115:10-5 pubmed
    b>Calreticulin (CRT) is a multifunctional Ca(2+)-binding protein that mainly functions in the endoplasmic reticulum as a molecular chaperone for newly synthesized proteins...
  38. Kabbage M, Trimeche M, Bergaoui S, Hammann P, Kuhn L, Hamrita B, et al. Calreticulin expression in infiltrating ductal breast carcinomas: relationships with disease progression and humoral immune responses. Tumour Biol. 2013;34:1177-88 pubmed publisher
    The aim of this study was to evaluate calreticulin expression in infiltrating ductal breast carcinomas (IDCAs), as well as its relationships with clinicopathological parameters of the disease...
  39. Wang X, Shang L, Zhang Y, Hao J, Shi F, Luo W, et al. PTP1B contributes to calreticulin-induced metastatic phenotypes in esophageal squamous cell carcinoma. Mol Cancer Res. 2013;11:986-94 pubmed publisher
    b>Calreticulin (CRT) is a Ca(2+)-binding chaperone protein that alters cellular Ca(2+)-homeostasis in the endoplasmic reticulum (ER)...
  40. Holaska J, Black B, Love D, Hanover J, Leszyk J, Paschal B. Calreticulin Is a receptor for nuclear export. J Cell Biol. 2001;152:127-40 pubmed
    ..Acad. Sci. USA. 95: 14739-14744). Here, we describe the purification and characterization of the activity as calreticulin (CRT), a protein previously ascribed to functions in the lumen of the ER...
  41. Sandhu N, Duus K, Jørgensen C, Hansen P, Bruun S, Pedersen L, et al. Peptide binding specificity of the chaperone calreticulin. Biochim Biophys Acta. 2007;1774:701-13 pubmed
    b>Calreticulin is a molecular chaperone with specificity for polypeptides and N-linked monoglucosylated glycans...
  42. Du X, Yang H, Liu S, Luo M, Hao J, Zhang Y, et al. Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma. Oncogene. 2009;28:3714-22 pubmed publisher
    We have shown earlier that overexpression of Calreticulin (CRT) contributed to a poor prognosis for patients with esophageal squamous cell carcinoma (ESCC)...
  43. Jeffery E, Peters L, Raghavan M. The polypeptide binding conformation of calreticulin facilitates its cell-surface expression under conditions of endoplasmic reticulum stress. J Biol Chem. 2011;286:2402-15 pubmed publisher
    We define two classes of calreticulin mutants that retain glycan binding activity; those that display enhanced or reduced polypeptide-specific chaperone activity, due to conformational effects...
  44. Lee K, Kim S, Kim D, Jo S, Joong Lee S, Choi S. Prostaglandin modulates TLR3-induced cytokine expression in human astroglioma cells. Brain Res. 2014;1589:54-60 pubmed publisher
    ..the effect of prostaglandins on toll-like receptor 3 (TLR3)-induced cytokine expression in human astroglioma CRT-MG cells. Prostaglandin E2 (PGE2) was shown to increase cytosolic cAMP levels in an EP2 receptor dependent manner...
  45. Starmer H, Yang W, Gourin C, Kumar R, Jones B, McNutt T, et al. One-Year Swallowing Outcomes in Patients Treated with Prophylactic Gabapentin During Radiation-Based Treatment for Oropharyngeal Cancer. Dysphagia. 2017;32:437-442 pubmed publisher
    ..by our study team have demonstrated patients using gabapentin for pain management during chemoradiotherapy (CRT) do well maintaining swallowing during treatment with less need for narcotic pain medication, PEG dependence, ..
  46. Kim D, Lubner M, Cahoon A, Pooler B, Pickhardt P. Flat Serrated Polyps at CT Colonography: Relevance, Appearance, and Optimizing Interpretation. Radiographics. 2017;:170110 pubmed publisher
    ..The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation...
  47. Roy R, Pratheeshkumar P, Son Y, Wang L, Hitron J, Divya S, et al. Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells. Toxicol Appl Pharmacol. 2016;307:81-90 pubmed publisher
    ..In contrast, in Cr(VI)-transformed (CrT) cells, Nrf2 is constitutively activated...
  48. Lekoane B, Mashamba Thompson T, Ginindza T. Mapping evidence on the distribution of human papillomavirus-related cancers in sub-Saharan Africa: scoping review protocol. Syst Rev. 2017;6:229 pubmed publisher
    ..main objective of this study is to map evidence on the distribution of HIV-related cancers in sub-Saharan Africa (SSA)...
  49. Sze E, Daubert J. Why the Authors Use Cardiac Resynchronization Therapy with Defibrillators. Card Electrophysiol Clin. 2015;7:695-707 pubmed publisher
    Cardiac resynchronization therapy (CRT) improves left ventricular function, especially in patients with left bundle branch block or those receiving chronic right ventricular pacing...
  50. Kutyifa V, Goldenberg I, Moss A. Lessons learned from the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT). Trends Cardiovasc Med. 2016;26:137-46 pubmed publisher
    Cardiac resynchronization therapy (CRT) has evolved as a Class I treatment indication with Level of Evidence A, in patients with mild heart failure, depressed left ventricular ejection fraction, and wide QRS...
  51. Chen C, You J, Lung J, Huang C, Chen Y, Leu Y, et al. Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms. Haematologica. 2017;102:509-518 pubmed publisher
  52. Morant N, Lloyd Evans B, Lamb D, Fullarton K, Brown E, Paterson B, et al. Crisis resolution and home treatment: stakeholders' views on critical ingredients and implementation in England. BMC Psychiatry. 2017;17:254 pubmed publisher
    ..In order to inform development of a more highly specified CRT model that meets service users' needs, this study used qualitative methods to investigate stakeholders' experiences ..
  53. Hyde E, Behar J, Claridge S, Jackson T, Lee A, Remme E, et al. Beneficial Effect on Cardiac Resynchronization From Left Ventricular Endocardial Pacing Is Mediated by Early Access to High Conduction Velocity Tissue: Electrophysiological Simulation Study. Circ Arrhythm Electrophysiol. 2015;8:1164-72 pubmed publisher
    Cardiac resynchronization therapy (CRT) delivered via left ventricular (LV) endocardial pacing (ENDO-CRT) is associated with improved acute hemodynamic response compared with LV epicardial pacing (EPI-CRT)...
  54. Adhikari K, Tatinati S, Veluvolu K, Chambers J, Nazarpour K. Real-time physiological tremor estimation using recursive singular spectrum analysis. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:3202-3205 pubmed publisher
    ..In this paper, we present a new technique based on singular spectrum analysis (SSA) and its recursive version, that is, recursive singular spectrum analysis (RSSA)...
  55. Jang J, Kim H, Huh J, Park Y, Cho Y, Yun S, et al. Anastomotic Leak Does Not Impact Oncologic Outcomes After Preoperative Chemoradiotherapy and Resection for Rectal Cancer. Ann Surg. 2017;: pubmed publisher
    The aim of this study was to evaluate the relationship of anastomotic leakage, local recurrence, and overall survival in rectal cancer patients treated with preoperative chemoradiotherapy (CRT) and curative resection.
  56. Tefferi A, Lasho T, Tischer A, Wassie E, Finke C, Belachew A, et al. The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants. Blood. 2014;124:2465-6 pubmed publisher
  57. Bode G, Hammer T, Karvouniaris N, Feucht M, Konstantinidis L, Südkamp N, et al. Patellar tendinopathy in young elite soccer- clinical and sonographical analysis of a German elite soccer academy. BMC Musculoskelet Disord. 2017;18:344 pubmed publisher
    ..Furthermore, sonographical examinations (Aplio SSA-770A/80; Toshiba, Tokyo, Japan) with 12-MHz multifrequency linear transducers (8-14 MHz) of both patellar ..
  58. Agarwal R, Blombery P, McBean M, Jones K, Fellowes A, Doig K, et al. Clinicopathological differences exist between CALR- and JAK2-mutated myeloproliferative neoplasms despite a similar molecular landscape: data from targeted next-generation sequencing in the diagnostic laboratory. Ann Hematol. 2017;96:725-732 pubmed publisher
  59. Markovina S, Wang S, Henke L, Luke C, Pak S, Dewees T, et al. Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer. Br J Cancer. 2017;: pubmed publisher
    ..SCCA has not been evaluated as an early indicator of response to chemoradiation therapy (CRT). The molecular role of the two SCCA isoforms, SCCA1 (SERPINB3) and SCCA2 (SERPINB4), in cervical cancer is unknown...
  60. Agyei B, Nicolaou M, Boateng L, Dijkshoorn H, van den Born B, Agyemang C. Relationship between psychosocial stress and hypertension among Ghanaians in Amsterdam, the Netherlands--the GHAIA study. BMC Public Health. 2014;14:692 pubmed publisher
    Hypertension is highly prevalent among recent sub-Saharan African (SSA) migrants in western countries and some tend to associate their hypertension to psychosocial stress...
  61. Chang H, Hur J, Won K, Chang B, Lee H. Recurrent maxillary sinus cancer with only adrenal metastasis. Mol Clin Oncol. 2017;7:847-850 pubmed publisher
    ..After three months of CRT, the patient developed a left adrenal gland metastasis without locoregional failure...
  62. Kronborg M, Johansen J, Haarbo J, Riahi S, Philbert B, Jørgensen O, et al. Association between implantable cardioverter-defibrillator therapy and different lead positions in patients with cardiac resynchronization therapy. Europace. 2017;: pubmed publisher
    ..evaluate the impact of different right and left ventricular lead positions (RV-LP and LV-LP) on the risk of therapy for ventricular tachycardia/ventricular fibrillation in patients with a cardiac resynchronization therapy device (CRT-D).
  63. Suzuki D, Matsumoto S, Mashima H. A Case with Serrated Polyposis Syndrome Controlled by Multiple Applications of Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection. Am J Case Rep. 2017;18:304-307 pubmed
    ..polyposis syndrome (SPS) is characterized by numerous hyperplastic polyps and sessile serrated adenoma/polyp (SSA/P) in the large intestine...