calmodulin

Summary

Gene Symbol: calmodulin
Description: calmodulin 1
Alias: CALML2, CAMI, CPVT4, DD132, LQT14, PHKD, caM, calmodulin-1, calmodulin 1 (phosphorylase kinase, delta), phosphorylase kinase subunit delta, phosphorylase kinase, delta subunit, prepro-calmodulin 1
Species: human
Products:     calmodulin

Top Publications

  1. Toutenhoofd S, Foletti D, Wicki R, Rhyner J, Garcia F, Tolon R, et al. Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3. Cell Calcium. 1998;23:323-38 pubmed
    Human calmodulin is encoded by three genes CALM1, CALM2 and CALM3 located on different chromosomes...
  2. Popov S, Krishna U, Falck J, Wilkie T. Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. J Biol Chem. 2000;275:18962-8 pubmed
    ..Conversely, the GAP activity of a palmitoylation-resistant mutant RGS4 is inhibited by PIP(3). Calmodulin binds all RGS proteins we tested in a Ca(2+)-dependent manner but does not directly affect GAP activity...
  3. Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, et al. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum Mol Genet. 2005;14:1009-17 pubmed
    ..8x10(-7)) between hip OA and a SNP (IVS3-293C>T) located in intron 3 of the calmodulin (CaM) 1 gene (CALM1)...
  4. Buelt M, Glidden B, Storm D. Regulation of p68 RNA helicase by calmodulin and protein kinase C. J Biol Chem. 1994;269:29367-70 pubmed
    ..that p68 possesses a region of sequence similarity to the conserved protein kinase C phosphorylation site and calmodulin binding domain (also known as the IQ domain) of the neural-specific proteins neuromodulin (GAP-43) and ..
  5. Antonsson A, Hughes K, Edin S, Grundström T. Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin. Mol Cell Biol. 2003;23:1418-27 pubmed
    ..b>Calmodulin (CaM) is a highly conserved, ubiquitously expressed Ca(2+) binding protein that serves as a key mediator of ..
  6. Ishikawa H, Sasaki M, Noda S, Koga Y. Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin. J Virol. 1998;72:6574-80 pubmed
    The role of calmodulin (CaM) in apoptosis induced by gp160 of human immunodeficiency virus type 1 was investigated with cells undergoing single-cell killing...
  7. Jang D, Guo M, Wang D. Proteomic and biochemical studies of calcium- and phosphorylation-dependent calmodulin complexes in Mammalian cells. J Proteome Res. 2007;6:3718-28 pubmed
    ..g., phosphorylation) modulate dynamic protein complexes. Calmodulin (CaM) plays an essential role in regulating calcium signaling and homeostasis...
  8. Lambert D, Clarke N, Hooper N, Turner A. Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain. FEBS Lett. 2008;582:385-90 pubmed
    ..In this study, we demonstrate that inhibitors of calmodulin also stimulate shedding of the ACE2 ectodomain, a process at least partially mediated by a metalloproteinase...
  9. Izumi Y, Watanabe H, Watanabe N, Aoyama A, Jinbo Y, Hayashi N. Solution X-ray scattering reveals a novel structure of calmodulin complexed with a binding domain peptide from the HIV-1 matrix protein p17. Biochemistry. 2008;47:7158-66 pubmed publisher
    The solution structures of complexes between calcium-saturated calmodulin (Ca (2+)/CaM) and a CaM-binding domain of the HIV-1 matrix protein p17 have been determined by small-angle X-ray scattering with use of synchrotron radiation as an ..

More Information

Publications82

  1. Xiong L, Kleerekoper Q, He R, Putkey J, Hamilton S. Sites on calmodulin that interact with the C-terminal tail of Cav1.2 channel. J Biol Chem. 2005;280:7070-9 pubmed
    ..2) have been expressed, refolded, and purified. A single Ca(2+)-calmodulin binds to each fragment, and this interaction with Ca(2+)-calmodulin is required for proper folding of the ..
  2. Meador W, Means A, Quiocho F. Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. Science. 1992;257:1251-5 pubmed
    The crystal structure of calcium-bound calmodulin (Ca(2+)-CaM) bound to a peptide analog of the CaM-binding region of chicken smooth muscle myosin light chain kinase has been determined and refined to a resolution of 2.4 angstroms (A)...
  3. Micoli K, Mamaeva O, Piller S, Barker J, Pan G, Hunter E, et al. Point mutations in the C-terminus of HIV-1 gp160 reduce apoptosis and calmodulin binding without affecting viral replication. Virology. 2006;344:468-79 pubmed
    ..Prior studies have shown that binding of cellular calmodulin to the envelope glycoprotein (Env) of HIV-1 increases sensitivity to fas-mediated apoptosis and that calmodulin ..
  4. Nakamura F, Hartwig J, Stossel T, Szymanski P. Ca2+ and calmodulin regulate the binding of filamin A to actin filaments. J Biol Chem. 2005;280:32426-33 pubmed
    ..We report that Ca(2+)-calmodulin binds the actin-binding domain (ABD) of FLNa and dissociates FLNa from F-actin, thereby dissolving FLNa...
  5. Hart M, Callow M, Souza B, Polakis P. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 1996;15:2997-3005 pubmed
    ..Cdc42 was also co-immunoprecipitated from cell lysates with antibody specific to p195/IQGAP1. Calmodulin also co-immunoprecipitated with p195/IQGAP1 and was found to associate with fragments containing the IQ domain...
  6. Labasque M, Reiter E, Becamel C, Bockaert J, Marin P. Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. Mol Biol Cell. 2008;19:4640-50 pubmed publisher
    ..Here, we show that calmodulin (CaM) binds to a prototypic Ca(2+)-dependent "1-10" CaM-binding motif located in the proximal region ..
  7. Berchtold M, Egli R, Rhyner J, Hameister H, Strehler E. Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3. Genomics. 1993;16:461-5 pubmed
    The three bona fide genes coding for calmodulin CALM1, CALM2, and CALM3, were assigned to human chromosomes 14, 2, and 19, respectively, by polymerase chain reaction-based amplification of calmodulin gene-specific sequences using DNA from ..
  8. Chen P, Wu K. Two synthetic peptides corresponding to the proximal heme-binding domain and CD1 domain of human endothelial nitric-oxide synthase inhibit the oxygenase activity by interacting with CaM. Arch Biochem Biophys. 2009;486:132-40 pubmed publisher
    Human endothelial nitric-oxide synthase (eNOS) is a complex enzyme, requiring binding of calmodulin (CaM) for electron transfer...
  9. Hayashi N, Matsubara M, Jinbo Y, Titani K, Izumi Y, Matsushima N. Nef of HIV-1 interacts directly with calcium-bound calmodulin. Protein Sci. 2002;11:529-37 pubmed
    ..protein kinase C substrate, is essential for the interaction between the protein and Ca(2+)-bound calmodulin (Ca(2+)/CaM)...
  10. Ghanam R, Fernandez T, Fledderman E, Saad J. Binding of calmodulin to the HIV-1 matrix protein triggers myristate exposure. J Biol Chem. 2010;285:41911-20 pubmed publisher
    ..HIV-1 Gag was shown to interact and co-localize with calmodulin (CaM), a ubiquitous and highly conserved Ca(2+)-binding protein expressed in all eukaryotic cells, and is ..
  11. Micoli K, Pan G, Wu Y, Williams J, Cook W, McDonald J. Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. J Biol Chem. 2000;275:1233-40 pubmed
    ..The HIV-1 envelope glycoprotein, gp160, contains two C-terminal calmodulin-binding domains...
  12. Zhang M, Yuan T. Molecular mechanisms of calmodulin's functional versatility. Biochem Cell Biol. 1998;76:313-23 pubmed
    b>Calmodulin (CaM) is a primary Ca2+-binding protein found in all eukaryotic cells...
  13. Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S. A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7. J Biol Chem. 1999;274:27573-7 pubmed
    ..Here, we report that calmodulin (CaM) directly binds to the carboxyl terminus of mGluR7 in a Ca(2+)-dependent manner...
  14. Loughlin J, Sinsheimer J, Carr A, Chapman K. The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population. Osteoarthritis Cartilage. 2006;14:295-8 pubmed
    ..with hip osteoarthritis (OA) of a functional single nucleotide polymorphism (SNP) in the core promoter of the calmodulin 1 gene CALM1 was recently reported in a Japanese population...
  15. Srinivas S, Srinivas R, Anantharamaiah G, Compans R, Segrest J. Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins. J Biol Chem. 1993;268:22895-9 pubmed
    b>Calmodulin (CaM), the major intracellular receptor for calcium, is involved in regulation of diverse cellular functions...
  16. Radding W, Williams J, McKenna M, Tummala R, Hunter E, Tytler E, et al. Calmodulin and HIV type 1: interactions with Gag and Gag products. AIDS Res Hum Retroviruses. 2000;16:1519-25 pubmed
    The level of calmodulin increases in cells expressing HIV-1 envelope glycoprotein...
  17. Ghanam R, Samal A, Fernandez T, Saad J. Role of the HIV-1 Matrix Protein in Gag Intracellular Trafficking and Targeting to the Plasma Membrane for Virus Assembly. Front Microbiol. 2012;3:55 pubmed publisher
    ..Exposure of the myr group is also triggered by binding of calmodulin, enhanced by factors that promote protein self-association like the capsid domain of Gag, and is modulated by pH...
  18. Kim E, Rumpf C, Van Petegem F, Arant R, Findeisen F, Cooley E, et al. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J. 2010;29:3924-38 pubmed publisher
    Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca(V) function. In this study, we report the structure of a Ca(2+)/CaM Ca(V)1...
  19. de Diego I, Kuper J, Bakalova N, Kursula P, Wilmanns M. Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex. Sci Signal. 2010;3:ra6 pubmed publisher
    Death-associated protein kinase (DAPK) provides a model for calcium-bound calmodulin (CaM)-dependent protein kinases (CaMKs)...
  20. Yamauchi E, Nakatsu T, Matsubara M, Kato H, Taniguchi H. Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin. Nat Struct Biol. 2003;10:226-31 pubmed
    The calmodulin-binding domain of myristoylated alanine-rich C kinase substrate (MARCKS), which interacts with various targets including calmodulin, actin and membrane lipids, has been suggested to function as a crosstalk point among ..
  21. Deng W, Srinivasan S, Zheng X, Putkey J, Li R. Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding. J Mol Biol. 2011;411:220-33 pubmed publisher
    The calmodulin (CaM) hypothesis of ectodomain shedding stipulates that CaM, an intracellular Ca²?-dependent regulatory protein, associates with the cytoplasmic domain of L-selectin to regulate ectodomain shedding of L-selectin on the ..
  22. Pan Z, Radding W, Zhou T, Hunter E, Mountz J, McDonald J. Role of calmodulin in HIV-potentiated Fas-mediated apoptosis. Am J Pathol. 1996;149:903-10 pubmed
    ..Many apoptotic pathways depend on calcium and therefore would be expected to involve calmodulin. As the HIV-1 envelope glycoprotein, gp160, contains two known calmodulin-binding domains, we investigated the ..
  23. Brill S, Li S, Lyman C, Church D, Wasmuth J, Weissbach L, et al. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol Cell Biol. 1996;16:4869-78 pubmed
    ..pombe sar1 RasGAP homolog. As predicted by the presence of IQ motifs, IQGAP2 binds calmodulin. However, neither full-length nor truncated IQGAP2 stimulated the GTPase activity of Ras or its close relatives...
  24. Li Z, Sacks D. Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. J Biol Chem. 2003;278:4347-52 pubmed
    b>Calmodulin regulates the function of numerous proteins by binding to short regions on the target molecule. IQ motifs, which are found in over 100 human proteins, appear in tandem repeats and bind calmodulin in the absence of Ca(2+)...
  25. Zhao D, Qiu G, Wang Y, Zhang J, Shen J, Wu Z, et al. Association of calmodulin1 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis. Orthop Surg. 2009;1:58-65 pubmed publisher
    ..The susceptibility of PUMC type II (double curve) AIS and lumbar curve might be related to CALM1 rs12885713 site polymorphism, while rs5871 site polymorphism might be a risk indicator for thoracic curve cases. ..
  26. Schumacher M, Rivard A, Bachinger H, Adelman J. Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. Nature. 2001;410:1120-4 pubmed
    ..channels are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca2+-binding protein calmodulin (CaM)...
  27. Sim H, Rimmer K, Kelly S, Ludbrook L, Clayton A, Harley V. Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal. Mol Endocrinol. 2005;19:1884-92 pubmed
    ..The SRY N-terminal NLS (n-NLS) binds calmodulin (CaM) in vitro, and here we show that this protein interaction is reduced in vivo by calmidazolium, a CaM ..
  28. Radding W, Pan Z, Hunter E, Johnston P, Williams J, McDonald J. Expression of HIV-1 envelope glycoprotein alters cellular calmodulin. Biochem Biophys Res Commun. 1996;218:192-7 pubmed
    Removal of parts of a known calmodulin binding site at the C-terminus of HIV-1 envelope glycoprotein, gp160, can result in diminished infectivity...
  29. Minakami R, Jinnai N, Sugiyama H. Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro. J Biol Chem. 1997;272:20291-8 pubmed
    ..We herein report that calmodulin (CaM) interacts with the metabotropic glutamate receptor subtype 5 (mGluR5) in a Ca2+-dependent manner in vitro...
  30. Chow J, Jeffries C, Kwan A, Guss J, Trewhella J. Calmodulin disrupts the structure of the HIV-1 MA protein. J Mol Biol. 2010;400:702-14 pubmed publisher
    ..interacts with host cell proteins and it has been reported that one of these is the ubiquitous calcium-sensing calmodulin (CaM), which is up-regulated upon HIV-1 infection...
  31. Fallon J, Halling D, Hamilton S, Quiocho F. Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channel. Structure. 2005;13:1881-6 pubmed
    Ca2+-dependent inactivation (CDI) and facilitation (CDF) of the Ca(v)1.2 Ca2+ channel require calmodulin binding to a putative IQ motif in the carboxy-terminal tail of the pore-forming subunit. We present the 1...
  32. Van Petegem F, Chatelain F, Minor D. Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nat Struct Mol Biol. 2005;12:1108-15 pubmed
    ..Ca(V)s) drive two self-regulatory calcium-dependent feedback processes that require interaction between Ca(2+)/calmodulin (Ca(2+)/CaM) and a Ca(V) channel consensus isoleucine-glutamine (IQ) motif: calcium-dependent inactivation (CDI) ..
  33. Matsubara M, Jing T, Kawamura K, Shimojo N, Titani K, Hashimoto K, et al. Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivo. Protein Sci. 2005;14:494-503 pubmed
    ..In the present report, we show that Nef can interact with calmodulin, the major intracellular receptor for calcium...
  34. Samal A, Ghanam R, Fernandez T, Monroe E, Saad J. NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein. J Biol Chem. 2011;286:33533-43 pubmed publisher
    Subcellular distribution of Calmodulin (CaM) in human immunodeficiency virus type-1 (HIV-1)-infected cells is distinct from that observed in uninfected cells...
  35. Shen Y, Zhukovskaya N, Guo Q, Flori n J, Tang W. Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J. 2005;24:929-41 pubmed publisher
    Edema factor (EF), a key anthrax exotoxin, has an anthrax protective antigen-binding domain (PABD) and a calmodulin (CaM)-activated adenylyl cyclase domain...
  36. Zainelli G, Ross C, Troncoso J, Fitzgerald J, Muma N. Calmodulin regulates transglutaminase 2 cross-linking of huntingtin. J Neurosci. 2004;24:1954-61 pubmed
    ..Because calmodulin regulates transglutaminase activity in erythrocytes, platelets, and the gizzard, we hypothesized that calmodulin ..
  37. Boczek N, Gómez Hurtado N, Ye D, Calvert M, Tester D, Kryshtal D, et al. Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G. Circ Cardiovasc Genet. 2016;9:136-146 pubmed publisher
    b>Calmodulin (CaM) is encoded by 3 genes, CALM1, CALM2, and CALM3, all of which harbor pathogenic variants linked to long QT syndrome (LQTS) with early and severe expressivity...
  38. Seet L, Liu N, Hanson B, Hong W. Endofin recruits TOM1 to endosomes. J Biol Chem. 2004;279:4670-9 pubmed
    ..A marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment, indicating TOM1 to be an effector for endofin and suggesting a possible role for TOM1 in endosomal trafficking. ..
  39. Hellstrand E, Kukora S, Shuman C, Steenbergen S, Thulin E, Kohli A, et al. Förster resonance energy transfer studies of calmodulin produced by native protein ligation reveal inter-domain electrostatic repulsion. FEBS J. 2013;280:2675-87 pubmed publisher
    This study explores the influence of long-range intra-protein electrostatic interactions on the conformation of calmodulin in solution...
  40. Yokokura H, Picciotto M, Nairn A, Hidaka H. The regulatory region of calcium/calmodulin-dependent protein kinase I contains closely associated autoinhibitory and calmodulin-binding domains. J Biol Chem. 1995;270:23851-9 pubmed
    The mechanism for the regulation of Ca2+/calmodulin-dependent protein kinase I (CaM kinase I) was investigated using a series of COOH-terminal truncated mutants...
  41. Newman R, Sorensen B, Kilpatrick A, Shea M. Calcium-dependent energetics of calmodulin domain interactions with regulatory regions of the Ryanodine Receptor Type 1 (RyR1). Biophys Chem. 2014;193-194:35-49 pubmed publisher
    b>Calmodulin (CaM) allosterically regulates the homo-tetrameric human Ryanodine Receptor Type 1 (hRyR1): apo CaM activates the channel, while (Ca(2+))4-CaM inhibits it...
  42. Boschek C, Sun H, Bigelow D, Squier T. Different conformational switches underlie the calmodulin-dependent modulation of calcium pumps and channels. Biochemistry. 2008;47:1640-51 pubmed publisher
    We have used fluorescence spectroscopy to investigate the structure of calmodulin (CaM) bound with CaM-binding sequences of either the plasma membrane Ca-ATPase or the skeletal muscle ryanodine receptor (RyR1) calcium release channel...
  43. Erdmann F, Sch uble N, Lang S, Jung M, Honigmann A, Ahmad M, et al. Interaction of calmodulin with Sec61? limits Ca2+ leakage from the endoplasmic reticulum. EMBO J. 2011;30:17-31 pubmed publisher
    ..We identified a calmodulin (CaM)-binding motif in the cytosolic N-terminus of mammalian Sec61? that bound CaM but not Ca2+-free ..
  44. Junker J, Rief M. Single-molecule force spectroscopy distinguishes target binding modes of calmodulin. Proc Natl Acad Sci U S A. 2009;106:14361-6 pubmed publisher
    The eukaryotic signaling protein calmodulin (CaM) can bind to more than 300 known target proteins to regulate numerous functions in our body in a calcium-dependent manner...
  45. Tokumitsu H, Enslen H, Soderling T. Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase. J Biol Chem. 1995;270:19320-4 pubmed
    Recent studies have demonstrated that Ca2+/calmodulin-dependent protein kinase IV (CaM-kinase IV) can mediate Ca(2+)-dependent regulation of gene expression through the phosphorylation of transcriptional activating proteins...
  46. Zamecnik J, Krskova L, Hacek J, Stetkarova I, Krbec M. Etiopathogenesis of adolescent idiopathic scoliosis: Expression of melatonin receptors 1A/1B, calmodulin and estrogen receptor 2 in deep paravertebral muscles revisited. Mol Med Rep. 2016;14:5719-5724 pubmed publisher
    ..signaling pathway, including melatonin receptors 1A/1B (MTNR1A/MTNR1B), estrogen receptor 2 (ESR2) and calmodulin (CALM1), has previously been suggested to be associated with AIS...
  47. Zhou H, Kim S, Kirk E, Tippens A, Sun H, Haeseleer F, et al. Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. J Neurosci. 2004;24:4698-708 pubmed
    Ca2+-binding protein-1 (CaBP1) is a Ca2+-binding protein that is closely related to calmodulin (CaM) and localized in somatodendritic regions of principal neurons throughout the brain, but how CaBP1 participates in postsynaptic Ca2+ ..
  48. Kim J, Oh J, Sung G. Regulation of MAP kinase Hog1 by calmodulin during hyperosmotic stress. Biochim Biophys Acta. 2016;1863:2551-2559 pubmed publisher
    ..These Ca2+ signals can be decoded by Ca2+ sensor calmodulin (CaM)...
  49. Bueno Silva B, Kawamoto D, Ando Suguimoto E, Casarin R, Alencar S, Rosalen P, et al. Brazilian red propolis effects on peritoneal macrophage activity: Nitric oxide, cell viability, pro-inflammatory cytokines and gene expression. J Ethnopharmacol. 2017;207:100-107 pubmed publisher
    ..Therefore, BRP has anti-inflammatory effects on macrophage activity by reducing NO levels and diminished release and expression of pro-inflammatory cytokine and genes, respectively. ..
  50. Ainscough J, Gerberick G, Kimber I, Dearman R. Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin. J Biol Chem. 2015;290:31151-61 pubmed publisher
    ..Probes with a signal-to-noise ratio of >3 were defined as biologically relevant. In these analyses, calmodulin was identified as a particularly strong hit, with a signal-to-noise ratio of ∼ 11...
  51. McCullar J, Larsen S, Millimaki R, Filtz T. Calmodulin is a phospholipase C-beta interacting protein. J Biol Chem. 2003;278:33708-13 pubmed
    ..library with the amino terminus of PLC beta 3 has yielded potential PLC beta 3 interacting proteins including calmodulin (CaM)...
  52. Bicket A, Mehrabi P, Naydenova Z, Wong V, Donaldson L, Stagljar I, et al. Novel regulation of equlibrative nucleoside transporter 1 (ENT1) by receptor-stimulated Ca2+-dependent calmodulin binding. Am J Physiol Cell Physiol. 2016;310:C808-20 pubmed publisher
    ..Here we report the identification of the calcium signaling transducer calmodulin (CaM) as an ENT1-interacting protein, via a conserved classic 1-5-10 motif in ENT1...
  53. Garnovskaya M, Mukhin Y, Vlasova T, Raymond J. Hypertonicity activates Na+/H+ exchange through Janus kinase 2 and calmodulin. J Biol Chem. 2003;278:16908-15 pubmed
    ..Inhibitors of Ca(2+)/calmodulin (CaM) and Janus kinase 2 (Jak2) attenuated this activation, whereas neither calcium chelation nor inhibitors of ..
  54. Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M. Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A. 2003;100:8002-6 pubmed
    ..Here, we show that the Ca2+-binding protein calmodulin binds to a 35-aa segment in the C terminus of TRPV1, and that disruption of the calmodulin-binding segment ..
  55. Lörinczi E, Helliwell M, Finch A, Stansfeld P, Davies N, Mahaut Smith M, et al. Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain. J Biol Chem. 2016;291:17907-18 pubmed publisher
    ..channel is remarkably sensitive to inhibition by intracellular calcium (Ca(2+) i) through binding of Ca(2+)-calmodulin to three sites adjacent to the eagD and cNBHD...
  56. Benitez M, Cochet C, Jimenez J. A surface plasmon resonance study of the interactions between the component subunits of protein kinase CK2 and two protein substrates, casein and calmodulin. Mol Cell Biochem. 2001;227:31-6 pubmed
    ..types of protein substrates, casein, the phosphorylation of which is activated by the regulatory subunit, and calmodulin, which belongs to the kind of substrates on which the catalytic subunit is downregulated by the regulatory ..
  57. Fanger C, Ghanshani S, Logsdon N, Rauer H, Kalman K, Zhou J, et al. Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. J Biol Chem. 1999;274:5746-54 pubmed
    ..Deletion analyses defined a requirement for the first 62 amino acids of the C-tail, and the binding of calmodulin to this region did not require Ca2+...
  58. Santos da Silva E, Mulinge M, Perez Bercoff D. The frantic play of the concealed HIV envelope cytoplasmic tail. Retrovirology. 2013;10:54 pubmed publisher
    ..It also considers the cellular and viral proteins that have been described to interact with the gp41-CT, with a particular focus on subtype-related polymorphisms. ..
  59. Rumi Masante J, Rusinga F, Lester T, Dunlap T, Williams T, Dunker A, et al. Structural basis for activation of calcineurin by calmodulin. J Mol Biol. 2012;415:307-17 pubmed publisher
    ..It is activated by the calcium sensor calmodulin (CaM)...
  60. Malvoisin E, Wild F. Inhibition of HIV-1, HIV-2 and SIV envelope glycoprotein-mediated cell fusion by calmodulin. Virus Res. 1997;50:119-27 pubmed
    b>Calmodulin, an EF-hand protein, inhibited the fusion between CD4+ human cells and cells stably expressing HIV-1 envelope proteins...
  61. Li Z, Zhang Y, Hedman A, Ames J, Sacks D. Calmodulin Lobes Facilitate Dimerization and Activation of Estrogen Receptor-α. J Biol Chem. 2017;292:4614-4622 pubmed publisher
    ..Gene expression controlled by ER-α is modulated by Ca2+ via calmodulin (CaM)...
  62. Choi J, Chiang A, Taulier N, Gros R, Pirani A, Husain M. A calmodulin-binding site on cyclin E mediates Ca2+-sensitive G1/s transitions in vascular smooth muscle cells. Circ Res. 2006;98:1273-81 pubmed
    ..We next determined that this Ca2+-responsive kinase activity was dependent on a direct interaction between calmodulin (CaM), one of the major Ca2+-signal transducers of eukaryotic cells, and cyclin E...
  63. Majava V, Wang C, Myllykoski M, Kangas S, Kang S, Hayashi N, et al. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Amino Acids. 2010;39:59-71 pubmed publisher
    ..One of the best-characterized protein ligands for MBP is calmodulin (CaM), a highly acidic calcium sensor...
  64. Dagher R, Briere C, Fève M, Zeniou M, Pigault C, Mazars C, et al. Calcium fingerprints induced by calmodulin interactors in eukaryotic cells. Biochim Biophys Acta. 2009;1793:1068-77 pubmed publisher
    ..Among the intracellular proteins involved in Ca2+-signal deciphering, calmodulin (CaM) plays a pivotal role in controlling Ca2+-homeostasis and downstream Ca2+-based signalling events...
  65. Sasaki M, Uchiyama J, Ishikawa H, Matsushita S, Kimura G, Nomoto K, et al. Induction of apoptosis by calmodulin-dependent intracellular Ca2+ elevation in CD4+ cells expressing gp 160 of HIV. Virology. 1996;224:18-24 pubmed
    ..W7, a calmodulin antagonist, blocked the elevation of Ca2+ as well as the resultant DNA fragmentation, which thus implies that ..
  66. Nunomura W, Isozumi N, Nakamura S, Jinbo Y, Ohki S, Kidokoro S, et al. Unique structural changes in calcium-bound calmodulin upon interaction with protein 4.1R FERM domain: novel insights into the calcium-dependent regulation of 4.1R FERM domain binding to membrane proteins by calmodulin. Cell Biochem Biophys. 2014;69:7-19 pubmed publisher
    b>Calmodulin (CaM) binds to the FERM domain of 80 kDa erythrocyte protein 4.1R (R30) independently of Ca(2+) but, paradoxically, regulates R30 binding to transmembrane proteins in a Ca(2+)-dependent manner...
  67. Todorov P, Hardisty R, Brown S. Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B). Biochem J. 2001;354:267-74 pubmed
    ..N-terminal sequencing and immunoblotting analysis identified the 17 kDa protein as calmodulin, whereas MS and immunoblotting analysis identified the 55 kDa protein as microtubule-associated protein-2B (MAP-..
  68. Briggs M, Li Z, Sacks D. IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. J Biol Chem. 2002;277:7453-65 pubmed
    ..The recently discovered calmodulin-binding protein IQGAP1 binds stoichiometrically to beta-catenin and regulates the association of beta-catenin ..
  69. Atcheson E, Hamilton E, Pathmanathan S, Greer B, Harriott P, Timson D. IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain. Biosci Rep. 2011;31:371-9 pubmed publisher
    ..A key binding partner is the calcium-sensing protein CaM (calmodulin)...
  70. Cobb J, Han C, Wills D, Roberts D. Structural elements within the methylation loop (residues 112-117) and EF hands III and IV of calmodulin are required for Lys(115) trimethylation. Biochem J. 1999;340 ( Pt 2):417-24 pubmed
    b>Calmodulin is trimethylated by a specific methyltransferase on Lys115, a residue located in a six amino acid loop (LGEKLT) between EF hands III and IV...
  71. García Palmero I, Villalobo A. Deletion of the calmodulin-binding domain of Grb7 impairs cell attachment to the extracellular matrix and migration. Biochem Biophys Res Commun. 2013;436:271-7 pubmed publisher
    The adaptor Grb7 is a calmodulin (CaM)-binding protein that participates in signaling pathways involved in cell migration, proliferation and the control of angiogenesis, and plays a significant role in tumor growth, its metastatic spread ..
  72. Sidhu R, Clough R, Bhullar R. Ca2+/calmodulin binds and dissociates K-RasB from membrane. Biochem Biophys Res Commun. 2003;304:655-60 pubmed
    We have investigated the interaction of calmodulin (CaM) with Ras-p21 and the significance of this association...
  73. Sacks D, Davis H, Crimmins D, McDonald J. Insulin-stimulated phosphorylation of calmodulin. Biochem J. 1992;286 ( Pt 1):211-6 pubmed
    b>Calmodulin is phosphorylated in vitro by the insulin-receptor tyrosine kinase and a variety of serine/threonine kinases. Here we report that insulin stimulates the phosphorylation of calmodulin on average 3-fold in intact rat hepatocytes...