CALM3

Summary

Gene Symbol: CALM3
Description: calmodulin 3
Alias: CaM, CaMIII, HEL-S-72, PHKD, PHKD3, calmodulin-3, epididymis secretory protein Li 72, phosphorylase kinase subunit delta, prepro-calmodulin 3
Species: human
Products:     CALM3

Top Publications

  1. de Diego I, Kuper J, Bakalova N, Kursula P, Wilmanns M. Molecular basis of the death-associated protein kinase-calcium/calmodulin regulator complex. Sci Signal. 2010;3:ra6 pubmed publisher
    Death-associated protein kinase (DAPK) provides a model for calcium-bound calmodulin (CaM)-dependent protein kinases (CaMKs)...
  2. Chou J, Li S, Klee C, Bax A. Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains. Nat Struct Biol. 2001;8:990-7 pubmed
    ..In contrast, the vast majority of side chains making up the target binding surface are locked into the same chi(1) rotameric states as in complexes with target peptide. ..
  3. Van Petegem F, Chatelain F, Minor D. Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. Nat Struct Mol Biol. 2005;12:1108-15 pubmed
    ..two self-regulatory calcium-dependent feedback processes that require interaction between Ca(2+)/calmodulin (Ca(2+)/CaM) and a Ca(V) channel consensus isoleucine-glutamine (IQ) motif: calcium-dependent inactivation (CDI) and calcium-..
  4. Friedrich F, Bausero P, Sun Y, Treszl A, Kramer E, Juhr D, et al. A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy. Eur Heart J. 2009;30:1648-55 pubmed publisher
    ..We screened the promoter region of human calmodulin III gene (CALM3) and identified a new -34T>A polymorphism with a T-allele frequency of 0.70...
  5. Toutenhoofd S, Foletti D, Wicki R, Rhyner J, Garcia F, Tolon R, et al. Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3. Cell Calcium. 1998;23:323-38 pubmed
    Human calmodulin is encoded by three genes CALM1, CALM2 and CALM3 located on different chromosomes...
  6. Mayans O, van der Ven P, Wilm M, Mues A, Young P, Fürst D, et al. Structural basis for activation of the titin kinase domain during myofibrillogenesis. Nature. 1998;395:863-9 pubmed
    ..Titin kinase phosphorylates the muscle protein telethonin in early differentiating myocytes, indicating that this kinase may act in myofibrillogenesis. ..
  7. Tan H, Kupershmidt S, Zhang R, Stepanovic S, Roden D, Wilde A, et al. A calcium sensor in the sodium channel modulates cardiac excitability. Nature. 2002;415:442-7 pubmed
    ..Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1)..
  8. Kim E, Rumpf C, Van Petegem F, Arant R, Findeisen F, Cooley E, et al. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J. 2010;29:3924-38 pubmed publisher
    Interactions between voltage-gated calcium channels (Ca(V)s) and calmodulin (CaM) modulate Ca(V) function. In this study, we report the structure of a Ca(2+)/CaM Ca(V)1...
  9. Ishikawa H, Sasaki M, Noda S, Koga Y. Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin. J Virol. 1998;72:6574-80 pubmed
    The role of calmodulin (CaM) in apoptosis induced by gp160 of human immunodeficiency virus type 1 was investigated with cells undergoing single-cell killing...

More Information

Publications135 found, 100 shown here

  1. Lehmann M, Masanetz S, Kramer S, Erfle V. HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner. J Cell Sci. 2006;119:4520-30 pubmed
    ..In summary, we suggest that Nef-induced CCL2/MCP-1 expression in astrocytes contributes to infiltration of monocytes into the brain, and thereby to progression of HAD. ..
  2. Kishnani P, Goldstein J, Austin S, Arn P, Bachrach B, Bali D, et al. Diagnosis and management of glycogen storage diseases type VI and IX: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2019;21:772-789 pubmed publisher
    ..of which are encoded by various genes: ɑ (PHKA1, PHKA2), β (PHKB), ɣ (PHKG1, PHKG2), and δ (CALM1, CALM2, CALM3)...
  3. Rellos P, Pike A, Niesen F, Salah E, Lee W, von Delft F, et al. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 2010;8:e1000426 pubmed publisher
    ..LTP triggers high-frequency calcium pulses that result in the activation of Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII)...
  4. Choudhary S, Rosenblatt K, Fang L, Tian B, Wu Z, Brasier A. High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathway. J Biol Chem. 2011;286:37187-95 pubmed publisher
    ..Six kinases were validated, including ATM, CDK2, -5, and -7, CALM3, MAPAKP5, and MAP3K/MEKK3...
  5. Boczek N, Gómez Hurtado N, Ye D, Calvert M, Tester D, Kryshtal D, et al. Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G. Circ Cardiovasc Genet. 2016;9:136-146 pubmed publisher
    Calmodulin (CaM) is encoded by 3 genes, CALM1, CALM2, and CALM3, all of which harbor pathogenic variants linked to long QT syndrome (LQTS) with early and severe expressivity...
  6. Boczek T, Lisek M, Ferenc B, Zylinska L. Cross talk among PMCA, calcineurin and NFAT transcription factors in control of calmodulin gene expression in differentiating PC12 cells. Biochim Biophys Acta Gene Regul Mech. 2017;1860:502-515 pubmed publisher
    ..CaM encoded by three genes Calm1, Calm2, Calm3, works to translate Ca2+ signal into changes in frequently opposite cellular activities...
  7. Duan S, Yao Z, Hou D, Wu Z, Zhu W, Wu M. Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J. 2007;26:3062-74 pubmed
    ..Together, our data suggest that phosphorylation of Pirh2 may act as a fine-tuning to maintain the balance of p53-Pirh2 autoregulatory feedback loop, which facilitates the tight regulation of p53 stability and tumor suppression. ..
  8. Wang A, Zhang G. Differential gene expression analysis in glioblastoma cells and normal human brain cells based on GEO database. Oncol Lett. 2017;14:6040-6044 pubmed publisher
    ..A key gene, called CALM3, was identified by Cytoscape software...
  9. Fischer R, Koller M, Flura M, Mathews S, Strehler Page M, Krebs J, et al. Multiple divergent mRNAs code for a single human calmodulin. J Biol Chem. 1988;263:17055-62 pubmed
    The isolation of a novel complementary DNA (cDNA) clone coding for human calmodulin (CaM) is reported...
  10. Pan Z, Radding W, Zhou T, Hunter E, Mountz J, McDonald J. Role of calmodulin in HIV-potentiated Fas-mediated apoptosis. Am J Pathol. 1996;149:903-10 pubmed
    ..These investigations provide a mechanism by which HIV-1 may induce apoptosis and a possible intracellular target for future therapeutics. ..
  11. Nunomura W, Takakuwa Y, Parra M, Conboy J, Mohandas N. Ca(2+)-dependent and Ca(2+)-independent calmodulin binding sites in erythrocyte protein 4.1. Implications for regulation of protein 4.1 interactions with transmembrane proteins. J Biol Chem. 2000;275:6360-7 pubmed
    In vitro protein binding assays identified two distinct calmodulin (CaM) binding sites within the NH(2)-terminal 30-kDa domain of erythrocyte protein 4.1 (4...
  12. Onions J, Hermann S, Grundstrom T. A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors. Biochemistry. 2000;39:4366-74 pubmed
  13. Cook W, Walter L, Walter M. Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex. Biochemistry. 1994;33:15259-65 pubmed
    The crystal structure of calmodulin (CaM) bound to trifluoperazine (TFP) has been determined and refined to a resolution of 2.45 A...
  14. Srinivas S, Srinivas R, Anantharamaiah G, Compans R, Segrest J. Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins. J Biol Chem. 1993;268:22895-9 pubmed
    Calmodulin (CaM), the major intracellular receptor for calcium, is involved in regulation of diverse cellular functions...
  15. Chatila T, Anderson K, Ho N, Means A. A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. J Biol Chem. 1996;271:21542-8 pubmed
    ..This three-step requirement is unique among the multifunctional Ca2+/calmodulin-dependent kinases. ..
  16. Benaim G, Villalobo A. Phosphorylation of calmodulin. Functional implications. Eur J Biochem. 2002;269:3619-31 pubmed
    Calmodulin (CaM) is phosphorylated in vitro and in vivo by multiple protein-serine/threonine and protein-tyrosine kinases...
  17. Shen Y, Zhukovskaya N, Zimmer M, Soelaiman S, Bergson P, Wang C, et al. Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc Natl Acad Sci U S A. 2004;101:3242-7 pubmed publisher
    Edema factor (EF), a key virulence factor in anthrax pathogenesis, has calmodulin (CaM)-activated adenylyl cyclase activity...
  18. Ziechner U, Schönherr R, Born A, Gavrilova Ruch O, Glaser R, Malesevic M, et al. Inhibition of human ether à go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. FEBS J. 2006;273:1074-86 pubmed
    ..potassium channels (hEAG1) open in response to membrane depolarization and they are inhibited by Ca2+/calmodulin (CaM), presumably binding to the C-terminal domain of the channel subunits...
  19. Sahoo N, Tröger J, Heinemann S, Schönherr R. Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B. FEBS Lett. 2010;584:3896-900 pubmed publisher
    ..Unique sensitivity of the channel to intracellular Ca(2+) is mediated by calmodulin (CaM) binding to the intracellular N- and C-termini of the channel...
  20. Bilbao A, Parkitna J, Engblom D, Perreau Lenz S, Sanchis Segura C, Schneider M, et al. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proc Natl Acad Sci U S A. 2008;105:17549-54 pubmed publisher
    ..These findings reveal a critical role for CaMKIV in the development and persistence of cocaine-induced behaviors, through mechanisms dissociated from acute effects on gene expression and CREB-dependent transcription. ..
  21. Miller M, Mietzner T, Cloyd M, Robey W, Montelaro R. Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein. AIDS Res Hum Retroviruses. 1993;9:1057-66 pubmed
    ..of HIV-1 TM protein (LLP-1) is shown in standard in vitro assays to bind efficiently to purified calmodulin (CaM) and to inhibit in vitro CaM-mediated stimulation of phosphodiesterase activity...
  22. Shen Y, Guo Q, Zhukovskaya N, Drum C, Bohm A, Tang W. Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site. Biochem Biophys Res Commun. 2004;317:309-14 pubmed publisher
    ..Here, we report a structure, at 3.0 A resolution, of the catalytic domain of EF (EF3) in complex with calmodulin (CaM) and adenosine 5'-(alpha,beta-methylene)-triphosphate (AMPCPP)...
  23. Kobayashi H, Saragai S, Naito A, Ichio K, Kawauchi D, Murakami F. Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons. Development. 2015;142:375-84 pubmed publisher
    ..In mammals, CaM is encoded by three non-allelic CaM (Calm) genes (Calm1, Calm2 and Calm3), which produce an identical protein with no amino acid substitutions...
  24. Baudier J, Mochly Rosen D, Newton A, Lee S, Koshland D, Cole R. Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C. Biochemistry. 1987;26:2886-93 pubmed
    ..abstract truncated at 250 words)..
  25. Wang P, Mao Y, Razo J, Zhou X, Wong S, Patel S, et al. Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients. Pharmacogenomics. 2010;11:1389-402 pubmed publisher
    ..Our results highlight the importance of incorporating both genetic and clinical, demographic factors into dose prediction. ..
  26. Flory M, Moser M, Monnat R, Davis T. Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin. Proc Natl Acad Sci U S A. 2000;97:5919-23 pubmed
    ..In mitotic human breast carcinoma cells containing abundant centrosome-like structures, kendrin is found only at centrosomes associated with spindle microtubules. ..
  27. Liu Y, Guo Y, Zhang L, Pei Y, Yu N, Yu P, et al. Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity. Obesity (Silver Spring). 2010;18:2339-46 pubmed publisher
    ..The study also highlights the importance of pathway-based GWA analysis in identification of additional genes/variants for complex human diseases. ..
  28. Kumar A, Rani B, Sharma R, Kaur G, Prasad R, Bahl A, et al. ACE2, CALM3 and TNNI3K polymorphisms as potential disease modifiers in hypertrophic and dilated cardiomyopathies. Mol Cell Biochem. 2018;438:167-174 pubmed publisher
    ..of single nucleotide polymorphisms (SNPs) of three candidate genes, ACE2 (rs6632677), TNNI3K (rs49812611) and CALM3 (rs13477425) with clinical phenotypes of HCM and DCM patients of North Indian ethnicity...
  29. Zhou H, Kim S, Kirk E, Tippens A, Sun H, Haeseleer F, et al. Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. J Neurosci. 2004;24:4698-708 pubmed
    Ca2+-binding protein-1 (CaBP1) is a Ca2+-binding protein that is closely related to calmodulin (CaM) and localized in somatodendritic regions of principal neurons throughout the brain, but how CaBP1 participates in postsynaptic Ca2+ ..
  30. Ren J, Li Z, Sacks D. IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J Biol Chem. 2008;283:22972-82 pubmed publisher
    ..Collectively, our data identify a previously unrecognized mechanism in which the scaffold protein IQGAP1 couples Ca(2+) and calmodulin signaling to B-Raf function. ..
  31. Micoli K, Mamaeva O, Piller S, Barker J, Pan G, Hunter E, et al. Point mutations in the C-terminus of HIV-1 gp160 reduce apoptosis and calmodulin binding without affecting viral replication. Virology. 2006;344:468-79 pubmed
    ..While spontaneous apoptosis appears to be at least partially calmodulin-independent, the effects of HIV-1 Env on fas-mediated apoptosis are directly related to calmodulin binding. ..
  32. Wright N, Prosser B, Varney K, Zimmer D, Schneider M, Weber D. S100A1 and calmodulin compete for the same binding site on ryanodine receptor. J Biol Chem. 2008;283:26676-83 pubmed publisher
    ..further characterized this system in skeletal muscle and showed that Ca(2+)-S100A1 competes with Ca(2+)-calmodulin (CaM) for the same binding site on RyR1...
  33. Tsang W, Bossard C, Khanna H, Peranen J, Swaroop A, Malhotra V, et al. CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Dev Cell. 2008;15:187-97 pubmed publisher
    ..Depletion of CEP290 interferes with localization of Rab8a to centrosomes and cilia. Our results suggest that CEP290 cooperates with Rab8a to promote ciliogenesis and that this function is antagonized by CP110. ..
  34. Garcia Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature. 1998;392:821-4 pubmed
    ..These observations indicate that in addition to its role as a molecular chaperone involved in protein folding and maturation, Hsp90 may also be recruited to cellular targets depending on the activation state of the cell. ..
  35. Li Z, Yue H, Xing D. MAP Kinase 6-mediated activation of vacuolar processing enzyme modulates heat shock-induced programmed cell death in Arabidopsis. New Phytol. 2012;195:85-96 pubmed publisher
    ..ROS) production, increase of cytoplasmic calcium concentration ([Ca(2+) ](cyt)) and the upregulation of calmodulin 3 (CaM3) transcript level occurred upstream of MPK6 activation...
  36. Navarro G, Aymerich M, Marcellino D, Cortés A, Casado V, Mallol J, et al. Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors. J Biol Chem. 2009;284:28058-68 pubmed publisher
    The Ca(2+)-binding protein calmodulin (CaM) has been shown to bind directly to cytoplasmic domains of some G protein-coupled receptors, including the dopamine D(2) receptor...
  37. Webb R. Smooth muscle contraction and relaxation. Adv Physiol Educ. 2003;27:201-6 pubmed
    ..Removal of Ca(2+) from the cytosol and stimulation of myosin phosphatase initiate the process of smooth muscle relaxation...
  38. Yuan T, Tencza S, Mietzner T, Montelaro R, Vogel H. Calmodulin binding properties of peptide analogues and fragments of the calmodulin-binding domain of simian immunodeficiency virus transmembrane glycoprotein 41. Biopolymers. 2001;58:50-62 pubmed
    The calcium-regulatory protein calmodulin (CaM) can bind with high affinity to a region in the cytoplasmic C-terminal tail of glycoprotein 41 of simian immunodeficiency virus (SIV)...
  39. Koller M, Strehler E. Functional analysis of the promoters of the human CaMIII calmodulin gene and of the intronless gene coding for a calmodulin-like protein. Biochim Biophys Acta. 1993;1163:1-9 pubmed
    More than 1 kb of the 5'-flanking DNA of the human CaMIII calmodulin gene and of the calmodulin-like protein (CLP) gene have been sequenced...
  40. Verrier F, Charneau P, Altmeyer R, Laurent S, Borman A, Girard M. Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate. Proc Natl Acad Sci U S A. 1997;94:9326-31 pubmed
  41. Radding W, Williams J, McKenna M, Tummala R, Hunter E, Tytler E, et al. Calmodulin and HIV type 1: interactions with Gag and Gag products. AIDS Res Hum Retroviruses. 2000;16:1519-25 pubmed
    ..These binding sites are nearly contiguous, forming an extended calmodulin-binding domain p17(11-46). In H-9 cells, Gag and calmodulin colocalize within the resolution of confocal light microscopy. ..
  42. Wu Y, Lin X, Liu C, Jamrich M, Shaffer L. Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily. Mol Genet Metab. 2001;72:343-50 pubmed
  43. Michel J, Feron O, Sacks D, Michel T. Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin. J Biol Chem. 1997;272:15583-6 pubmed
    ..These findings may have broad implications for the regulation of Ca2+-dependent signal transduction in plasmalemmal caveolae. ..
  44. Wang D, Surratt C, Sadee W. Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell. J Neurochem. 2000;75:763-71 pubmed
    Calmodulin (CaM) has been shown to suppress basal G protein coupling and attenuate agonist-stimulated G protein coupling of the mu-opioid receptor (OP(3)) through direct interaction with the third intracellular (i3) loop of the receptor...
  45. Yu C, Ko J, Ai T, Tsai W, Chen Z, Rubart M, et al. Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current. Heart Rhythm. 2016;13:1716-23 pubmed publisher
    ..4-93.3 ms] to 121.8 ms [97.9-127.2 ms]; P = .010) in hearts pretreated with anemone toxin but not in control hearts. Human arrhythmogenic calmodulin mutations impede the activation of SK2 channels in human embryonic kidney 293 cells. ..
  46. Martoglio B, Graf R, Dobberstein B. Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin. EMBO J. 1997;16:6636-45 pubmed
    ..The functional consequences of such interactions remain to be established. However, our data suggest that signal sequences may be functionally more versatile than anticipated up to now. ..
  47. Yamauchi E, Nakatsu T, Matsubara M, Kato H, Taniguchi H. Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin. Nat Struct Biol. 2003;10:226-31 pubmed
    ..We present here the crystal structure at 2 A resolution of a peptide consisting of the MARCKS calmodulin (CaM)-binding domain in complex with Ca2+-CaM...
  48. Young P, Ehler E, Gautel M. Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J Cell Biol. 2001;154:123-36 pubmed
  49. Saugstad J, Yang S, Pohl J, Hall R, Conn P. Interaction between metabotropic glutamate receptor 7 and alpha tubulin. J Neurochem. 2002;80:980-8 pubmed
  50. Li H, Ruano M, Villalobo A. Endogenous calmodulin interacts with the epidermal growth factor receptor in living cells. FEBS Lett. 2004;559:175-80 pubmed
    We have previously shown that exogenous calmodulin (CaM) binds to the epidermal growth factor receptor (EGFR) at its cytosolic juxtamembrane region inhibiting its tyrosine kinase activity...
  51. Chagot B, Chazin W. Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5. J Mol Biol. 2011;406:106-19 pubmed publisher
    ..5 is regulated in part by intracellular calcium signals. The ubiquitous calcium sensor protein calmodulin (CaM) is an important part of the complex calcium-sensing apparatus in Na(V)1.5...
  52. Zhao C, Malicki J. Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos. EMBO J. 2011;30:2532-44 pubmed publisher
    ..These studies reveal a molecular mechanism that mediates the transport of selected ciliary cargos and is of fundamental importance for the differentiation and survival of sensory cells. ..
  53. Anborgh P, Qian X, Papageorge A, Vass W, DeClue J, Lowy D. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol Cell Biol. 1999;19:4611-22 pubmed
  54. Locke D, Liu C, Peng X, Chen H, Kahn M. Fc Rgamma -independent signaling by the platelet collagen receptor glycoprotein VI. J Biol Chem. 2003;278:15441-8 pubmed
  55. Ogata Y, Slepecky N, Takahashi M. Study of the gerbil utricular macula following treatment with gentamicin, by use of bromodeoxyuridine and calmodulin immunohistochemical labelling. Hear Res. 1999;133:53-60 pubmed
    ..Our results suggest that the bromodeoxyuridine-labelled cells could not be positively identified as hair cells based on immunohistochemical labelling for calmodulin...
  56. Schuh K, Uldrijan S, Telkamp M, Rothlein N, Neyses L. The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J Cell Biol. 2001;155:201-5 pubmed
    ..Elucidation of PMCA as an interaction partner and major regulator of NOS-I provides evidence for a new dimension of integration between calcium and NO signaling pathways. ..
  57. Kelly S, Yotis J, Macris M, Harley V. Recombinant expression, purification and characterisation of the HMG domain of human SRY. Protein Pept Lett. 2003;10:281-6 pubmed
    ..Functional characterisation studies of the pure, concentrated SRY HMG domain show the recombinantly expressed protein to be active in terms of DNA binding and calmodulin binding activities. ..
  58. Shen C, Ye Y, Robertson S, Lau A, Mak D, Chou M. Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. J Biol Chem. 2005;280:35967-73 pubmed
    ..In the current study, we identified the ubiquitous calcium (Ca2+)-binding protein calmodulin (CaM) as a novel binding partner for TRE17...
  59. Gómez Hurtado N, Boczek N, Kryshtal D, Johnson C, Sun J, Nitu F, et al. Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. Circ Arrhythm Electrophysiol. 2016;9: pubmed publisher
    ..We performed mutational analysis of CALM1, CALM2, and CALM3 gene-coding regions, in vitro measurement of CaM-Ca(2+) (Ca)-binding affinity, ryanodine receptor 2-CaM binding, ..
  60. King M, Huang C, Chock P, Nairn A, Hemmings H, Chan K, et al. Mammalian brain phosphoproteins as substrates for calcineurin. J Biol Chem. 1984;259:8080-3 pubmed
    ..053 s-1; synapsin I (site II), 0.040 s-1. Comparisons of the catalytic efficiency (kcat/Km) for each substrate indicated that DARPP-32, G-substrate, and Protein K.-F. are all potential substrates for calcineurin in vivo. ..
  61. Limpitikul W, Dick I, Tester D, Boczek N, Limphong P, Yang W, et al. A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome. Circ Res. 2017;120:39-48 pubmed publisher
    ..arrhythmia syndromes capable of producing severe long-QT syndrome (LQTS) with mutations involving CALM1, CALM2, or CALM3. The underlying basis of this form of LQTS is a disruption of Ca2+/calmodulin (CaM)-dependent ..
  62. Lishko P, Procko E, Jin X, Phelps C, Gaudet R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron. 2007;54:905-18 pubmed
  63. Labasque M, Reiter E, Becamel C, Bockaert J, Marin P. Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. Mol Biol Cell. 2008;19:4640-50 pubmed publisher
    ..Here, we show that calmodulin (CaM) binds to a prototypic Ca(2+)-dependent "1-10" CaM-binding motif located in the proximal region of the 5-..
  64. Vassilakopoulou V, Calver B, Thanassoulas A, Beck K, Hu H, Buntwal L, et al. Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease. Biochim Biophys Acta. 2015;1850:2168-76 pubmed publisher
    Calmodulin (CaM) is a cytoplasmic calcium sensor that interacts with the cardiac ryanodine receptor (RyR2), a large Ca(2+) channel complex that mediates Ca(2+) efflux from the sarcoplasmic reticulum (SR) to activate cardiac muscle ..
  65. García Pedrero J, del Rio B, Martinez Campa C, Muramatsu M, Lazo P, Ramos S. Calmodulin is a selective modulator of estrogen receptors. Mol Endocrinol. 2002;16:947-60 pubmed
    ..search for differences between ERalpha and ERbeta, we analyzed the interaction of both receptors with calmodulin (CaM) and demonstrated that ERalpha but not ERbeta directly interacts with CaM...
  66. Shao D, Zhao M, Xu J, Feng R, Guo F, Hu H, et al. The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart. FEBS Lett. 2014;588:3855-61 pubmed publisher
    The present study examined the binding of the individual N- and C-lobes of calmodulin (CaM) to Cav1.2 at different Ca(2+) concentration ([Ca(2+)]) from ≈ free to 2mM, and found that they may bind to Cav1.2 Ca(2+)-dependently...
  67. Siedlecka M, Goch G, Ejchart A, Sticht H, Bierzynski A. Alpha-helix nucleation by a calcium-binding peptide loop. Proc Natl Acad Sci U S A. 1999;96:903-8 pubmed
    ..In light of our findings, thermodynamics of the nascent alpha-helices is discussed. The problem of CD spectra of very short alpha-helices is also addressed...
  68. Qu K, Lu Y, Lin N, Singh R, Xu X, Payan D, et al. Computational and experimental studies on human misshapen/NIK-related kinase MINK-1. Curr Med Chem. 2004;11:569-82 pubmed
    ..Further medicinal chemistry compound structure optimization and kinase assays are underway. ..
  69. Wawrzynczak E, Perham R. Isolation and nucleotide sequence of a cDNA encoding human calmodulin. Biochem Int. 1984;9:177-85 pubmed
  70. Berchtold M, Egli R, Rhyner J, Hameister H, Strehler E. Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3. Genomics. 1993;16:461-5 pubmed
    The three bona fide genes coding for calmodulin CALM1, CALM2, and CALM3, were assigned to human chromosomes 14, 2, and 19, respectively, by polymerase chain reaction-based amplification of calmodulin gene-specific sequences using DNA ..
  71. Izumi Y, Watanabe H, Watanabe N, Aoyama A, Jinbo Y, Hayashi N. Solution X-ray scattering reveals a novel structure of calmodulin complexed with a binding domain peptide from the HIV-1 matrix protein p17. Biochemistry. 2008;47:7158-66 pubmed publisher
    The solution structures of complexes between calcium-saturated calmodulin (Ca (2+)/CaM) and a CaM-binding domain of the HIV-1 matrix protein p17 have been determined by small-angle X-ray scattering with use of synchrotron radiation as an ..
  72. Zhou Q, Zhao L, Wang P, Badr R, Xu X, Bu F, et al. Comprehensive analysis of the association of EGFR, CALM3 and SMARCD1 gene polymorphisms with BMD in Caucasian women. PLoS ONE. 2014;9:e112358 pubmed publisher
    Three genes, including EGFR (epidermal growth factor receptor), CALM3 (calmodulin 3, calcium-modulated protein 3) and SMARCD1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily d member 1), play different ..
  73. Schönherr R, Lober K, Heinemann S. Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin. EMBO J. 2000;19:3263-71 pubmed
    ..However, Ca(2+) sensitivity could be restored by application of recombinant calmodulin (CaM). In the presence of CaM, half inhibition of hEAG1 channels was obtained in 100 nM Ca(2+)...
  74. Sharangdhar T, Sugimoto Y, Heraud Farlow J, Fernández Moya S, Ehses J, Ruiz de Los Mozos I, et al. A retained intron in the 3'-UTR of Calm3 mRNA mediates its Staufen2- and activity-dependent localization to neuronal dendrites. EMBO Rep. 2017;18:1762-1774 pubmed publisher
    ..to a retained intron in their 3'-UTR The strongest bound 3'-UTR intron was present in the longest isoform of Calmodulin 3 (Calm3L ) mRNA Calm3L 3'-UTR contains six Stau2 crosslink ..
  75. Gogstad G, Hagen I, Korsmo R, Solum N. Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981;670:150-62 pubmed
    ..The dominant three represented the main granule glycoprotein, glycoprotein IIb and glycoprotein IIIa, respectively. More glycoproteins seem to be present in the alpha-granules than was previously recognized. ..
  76. Rhyner J, Ottiger M, Wicki R, Greenwood T, Strehler E. Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2. Eur J Biochem. 1994;225:71-82 pubmed
    ..The exon-intron structure is identical to that of the human CALM3 and of the rat CALM1 and CALM3 genes...
  77. Sasaki M, Uchiyama J, Ishikawa H, Matsushita S, Kimura G, Nomoto K, et al. Induction of apoptosis by calmodulin-dependent intracellular Ca2+ elevation in CD4+ cells expressing gp 160 of HIV. Virology. 1996;224:18-24 pubmed
    ..The above results thus indicate that Ca2+ signalling plays a crucial role in the apoptosis accompanying the single-cell death induced by gp 160 in CD4+ cells. ..
  78. Tsang W, Spektor A, Luciano D, Indjeian V, Chen Z, Salisbury J, et al. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. Mol Biol Cell. 2006;17:3423-34 pubmed
    ..and biochemical analyses, we report that CP110 interacts with two different Ca2+-binding proteins, calmodulin (CaM) and centrin, in vivo...
  79. Xiao K, McClatchy D, Shukla A, Zhao Y, Chen M, Shenoy S, et al. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A. 2007;104:12011-6 pubmed
    ..This study provides a comprehensive analysis of proteins that bind beta-arrestin isoforms and underscores their potentially broad regulatory roles in mammalian cellular physiology. ..
  80. Atcheson E, Hamilton E, Pathmanathan S, Greer B, Harriott P, Timson D. IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain. Biosci Rep. 2011;31:371-9 pubmed publisher
    ..A key binding partner is the calcium-sensing protein CaM (calmodulin)...
  81. Chattopadhyaya R, Meador W, Means A, Quiocho F. Calmodulin structure refined at 1.7 A resolution. J Mol Biol. 1992;228:1177-92 pubmed
    ..The crystal packing is extensively studied, and facile crystal growth along the z-axis of the triclinic crystals is explained. Herein, we describe hydrogen bonding in the various secondary structure elements and hydration of calmodulin. ..
  82. Pegues J, Friedberg F. Multiple mRNAs encoding human calmodulin. Biochem Biophys Res Commun. 1990;172:1145-9 pubmed
    ..The poly A+ mRNA was isolated from human erythroleukemia cells and also from human B cells infected with EBV. ..
  83. Minakami R, Jinnai N, Sugiyama H. Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro. J Biol Chem. 1997;272:20291-8 pubmed
    ..We herein report that calmodulin (CaM) interacts with the metabotropic glutamate receptor subtype 5 (mGluR5) in a Ca2+-dependent manner in vitro...
  84. Mariotti M, De Benedictis L, Avon E, Maier J. Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo. J Biol Chem. 2000;275:24047-51 pubmed
    Calmodulin (CaM) is the principal Ca(2+) receptor protein inside the cell. When activated by Ca(2+), CaM binds and activates target proteins, thus altering the metabolism and physiology of the cell...
  85. Lemrow S, Anderson K, Joseph J, Ribar T, Noeldner P, Means A. Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus. J Biol Chem. 2004;279:11664-71 pubmed
    ..role for calmodulin or protein phosphatase 2A, the catalytically inactive CaMKIV proteins interact more avidly with CaM-dependent protein kinase kinase (CaMKK), which is restricted to the cytoplasm...
  86. Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, et al. Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction. Biochem Biophys Res Commun. 2010;394:660-6 pubmed publisher
    Calmodulin (CaM), one of the accessory proteins of the cardiac ryanodine receptor (RyR2), is known to play a significant role in the channel regulation of the RyR2...
  87. Samal A, Ghanam R, Fernandez T, Monroe E, Saad J. NMR, biophysical, and biochemical studies reveal the minimal Calmodulin binding domain of the HIV-1 matrix protein. J Biol Chem. 2011;286:33533-43 pubmed publisher
    Subcellular distribution of Calmodulin (CaM) in human immunodeficiency virus type-1 (HIV-1)-infected cells is distinct from that observed in uninfected cells...
  88. Guo T, Fruen B, Nitu F, Nguyen T, Yang Y, Cornea R, et al. FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel. Biophys J. 2011;101:2170-7 pubmed publisher
    Calmodulin (CaM) binding to the type 2 ryanodine receptor (RyR2) regulates Ca release from the cardiac sarcoplasmic reticulum (SR)...
  89. Wu Z, Li J, Huang M, Cheng J, Li H, Chen J, et al. Internal driving factors leading to extrahepatic manifestation of the hepatitis C virus infection. Int J Mol Med. 2017;40:1792-1802 pubmed publisher
    ..Ten genes, SOS1, RAF1, IFNA2, IFNG, MTHFR, IGF1, CALM3, UBE2B, TP53 and BMP7 whose expression may be the key internal driving molecules, were selected using the online ..
  90. Koller M, Schnyder B, Strehler E. Structural organization of the human CaMIII calmodulin gene. Biochim Biophys Acta. 1990;1087:180-9 pubmed
    ..The structure of the human calmodulin III gene promoter indicates that this gene belongs to a class of 'house-keeping' genes but that its level of expression may also be specifically regulated. ..
  91. Williams C, Phelps S, Porter R. Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in smal. Biochem Pharmacol. 1996;51:707-15 pubmed
    ..Evidence was found demonstrating that the activation of Ca2+/calmodulin-dependent protein kinase (CaM kinase) inhibits cell cycle progression in small cell lung carcinoma (SCLC) cells...
  92. Friedberg F, Rhoads A. Sequence homology of the 3'-untranslated region of calmodulin III in mammals. Mol Biol Rep. 2001;28:27-30 pubmed
    Calmodulin (CaM) has three separate nonallelic genes that encode for three identical proteins. These genes differ considerably in the 5'- and 3'-untranslated regions (UTR) and in the promoter region...