caldecrin

Summary

Gene Symbol: caldecrin
Description: chymotrypsin C (caldecrin)
Alias: CLCR, ELA4, caldecrin, chymotrypsin-C, elastase 4, elastase IV, serum calcium decreasing factor
Species: human

Top Publications

  1. ncbi Tertatolol in chronic renal failure. A pharmacokinetic study
    M Rainfray
    , , Bobigny, France
    Am J Hypertens 2:266S-277S. 1989
  2. doi Population pharmacokinetics of ganciclovir following administration of valganciclovir in paediatric renal transplant patients
    Wei Zhao
    Department of Paediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    Clin Pharmacokinet 48:321-8. 2009
  3. pmc Pollution-affected fish hepatic transcriptome and its expression patterns on exposure to cadmium
    M Auslander
    Israel Oceanographic and Limnological Research, Haifa 31080, Israel
    Mar Biotechnol (NY) 10:250-61. 2008
  4. ncbi Standardization of plasma brain natriuretic peptide concentrations in older Japanese-relationship to latent renal dysfunction and ischemic heart disease
    Hideki Nomura
    Department of Internal Medicine, Chubu Hospital, Obu, Aichi, Japan
    J Am Geriatr Soc 50:1504-9. 2002
  5. ncbi Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation
    F X Gomis-Rüth
    Institut de Biologia Fonamental i Departament de Bioquímica i BiologiaMolecular, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Mol Biol 269:861-80. 1997
  6. ncbi Influence of diurnal blood pressure variations on target organ abnormalities in adolescents with mild essential hypertension
    C W Belsha
    Department of Pediatrics, University of Arkansas for Medical Sciences and the Arkansas Children's Hospital, Little Rock 72202, USA
    Am J Hypertens 11:410-7. 1998
  7. ncbi Clinical pharmacokinetics and pharmacodynamics of isepamicin
    M Tod
    Department of Pharmacotoxicology, Avicenne Hospital, Bobigny, France
    Clin Pharmacokinet 38:205-23. 2000
  8. ncbi CT can reduce hospitalization for observation in children with suspected appendicitis
    Robert Acosta
    Deptartment of Pediatrics, Albert Einstein College of Medicine, 1W20 Jacobi Medical Center, 1400 Pelham Parkway, Bronx, NY 10461, USA
    Pediatr Radiol 35:495-500. 2005
  9. pmc Evaluation of several dosing regimens of cefepime, with various simulations of renal function, against clinical isolates of Pseudomonas aeruginosa in a pharmacodynamic infection model
    D M Cappelletty
    Division of Infectious Diseases, Harper Hospital, Wayne State University, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 43:129-33. 1999
  10. ncbi Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor agent in animal model and in patients with impaired renal function
    Masataka Ikeda
    Department of Surgery and Clinical Oncology E2, Graduate School of Medicine, Osaka University, Suita, Japan
    Cancer Chemother Pharmacol 50:25-32. 2002

Research Grants

  1. MICROBIAL DEGRADATION OF AGENT ORANGE
    Ananda Chakrabarty; Fiscal Year: 2000
  2. SOUTHWEST ONCOLOGY GROUP - OPERATIONS OFFICE
    Laurence Baker; Fiscal Year: 2007
  3. Chymotrypsin C in pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2009
  4. Chymotrypsin C in pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2010
  5. Chymotrypsin C in pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2009
  6. DOSAGE COMPENSATION OF THE ACTIVE X CHROMOSOME IN MAMMALS
    Christine M Disteche; Fiscal Year: 2010
  7. DOSAGE COMPENSATION OF THE ACTIVE X CHROMOSOME IN MAMMALS
    Christine Disteche; Fiscal Year: 2007
  8. Chymotrypsin C in pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2009
  9. Regulation of Capsule Biosynthesis in N. meningitidis
    David Stephens; Fiscal Year: 2006
  10. CLEK STUDY CORNEAL TOPOGRAPHY READING CENTER
    Timothy McMahon; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications135 found, 100 shown here

  1. ncbi Tertatolol in chronic renal failure. A pharmacokinetic study
    M Rainfray
    , , Bobigny, France
    Am J Hypertens 2:266S-277S. 1989
    ..6 +/- 12.3 years) with chronic renal failure defined by a mean creatinine clearance (Clcr) of 24.6 +/- 15.9 mL/min/1.73 m2 (range: 6.2 to 68.7)...
  2. doi Population pharmacokinetics of ganciclovir following administration of valganciclovir in paediatric renal transplant patients
    Wei Zhao
    Department of Paediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    Clin Pharmacokinet 48:321-8. 2009
    ....
  3. pmc Pollution-affected fish hepatic transcriptome and its expression patterns on exposure to cadmium
    M Auslander
    Israel Oceanographic and Limnological Research, Haifa 31080, Israel
    Mar Biotechnol (NY) 10:250-61. 2008
    ..Prominently differentially expressed genes included elastase 4, carboxypeptidase B, trypsinogen, perforin, complement C31, cytochrome P450 2K5, ceruloplasmin, carboxyl ester ..
  4. ncbi Standardization of plasma brain natriuretic peptide concentrations in older Japanese-relationship to latent renal dysfunction and ischemic heart disease
    Hideki Nomura
    Department of Internal Medicine, Chubu Hospital, Obu, Aichi, Japan
    J Am Geriatr Soc 50:1504-9. 2002
    ..To investigate the relationship between cyclic guanosine monophosphate (cGMP) and BNP in older people with and without ischemic heart disease (IHD)...
  5. ncbi Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation
    F X Gomis-Rüth
    Institut de Biologia Fonamental i Departament de Bioquímica i BiologiaMolecular, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Mol Biol 269:861-80. 1997
    ..of the zymogen of a metalloexopeptidase, carboxypeptidase A, and the proforms of two serine endopeptidases, chymotrypsin C and proteinase E. The crystal structure of the bovine complex has been solved and refined to an R-factor of 0...
  6. ncbi Influence of diurnal blood pressure variations on target organ abnormalities in adolescents with mild essential hypertension
    C W Belsha
    Department of Pediatrics, University of Arkansas for Medical Sciences and the Arkansas Children's Hospital, Little Rock 72202, USA
    Am J Hypertens 11:410-7. 1998
    ..Creatinine clearance (Clcr) and urine Malb was measured on 24 h collection and RFR by change in creatinine clearance after an oral protein ..
  7. ncbi Clinical pharmacokinetics and pharmacodynamics of isepamicin
    M Tod
    Department of Pharmacotoxicology, Avicenne Hospital, Bobigny, France
    Clin Pharmacokinet 38:205-23. 2000
    ..In patients with chronic renal impairment, isepamicin clearance is proportional to creatinine clearance (CLCR); the recommended regimen is 8 mg/kg with an administration interval of 24 hours in moderate impairment, 48 hours ..
  8. ncbi CT can reduce hospitalization for observation in children with suspected appendicitis
    Robert Acosta
    Deptartment of Pediatrics, Albert Einstein College of Medicine, 1W20 Jacobi Medical Center, 1400 Pelham Parkway, Bronx, NY 10461, USA
    Pediatr Radiol 35:495-500. 2005
    ..More than twice as many children hospitalized for abdominal pain suggesting appendicitis are subsequently sent home after observation compared to those who undergo appendectomy...
  9. pmc Evaluation of several dosing regimens of cefepime, with various simulations of renal function, against clinical isolates of Pseudomonas aeruginosa in a pharmacodynamic infection model
    D M Cappelletty
    Division of Infectious Diseases, Harper Hospital, Wayne State University, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 43:129-33. 1999
    ..and without tobramycin, and two different levels of renal function were simulated: normal (creatinine clearance [CLCR] = 90 ml/min) and decreased (CRCL = 60 ml/min)...
  10. ncbi Pharmacokinetic study of S-1, a novel oral fluorouracil antitumor agent in animal model and in patients with impaired renal function
    Masataka Ikeda
    Department of Surgery and Clinical Oncology E2, Graduate School of Medicine, Osaka University, Suita, Japan
    Cancer Chemother Pharmacol 50:25-32. 2002
    ..We sought to determine the influence of impaired renal function on the pharmacokinetics of S-1 in an animal model and in patients with gastric cancer...
  11. ncbi A study to evaluate the pharmacokinetics of oral 5-fluorouracil and eniluracil after concurrent administration to patients with refractory solid tumours and varying degrees of renal impairment (FUMA1005)
    ANNE O'DONNELL
    Clinical Pharmacology, E Block, Institute of Cancer Research, 15 Cotswold Road, Belmont, Surrey SM2 5NG, UK
    Cancer Chemother Pharmacol 51:58-66. 2003
    ..An open-label study was performed to determine the effect of renal impairment on the pharmacokinetics of 5-FU in the presence of eniluracil...
  12. doi Digestive efficiency, free amino acid pools and quality of growth performance in Atlantic salmon (Salmo salar L.) affected by light regimes and vaccine types
    Krisna Rungruangsak-Torrissen
    Institute of Marine Research, Matre Research Station, 5984 Matredal, Norway
    Fish Physiol Biochem 35:255-72. 2009
    ....
  13. ncbi Fluorescence polarization immunoassay: can it result in an overestimation of vancomycin in patients not suffering from renal failure?
    D Sym
    St John s University, College of Pharmacy and Allied Health Professions, Jamaica, New York, USA
    Ther Drug Monit 23:441-4. 2001
    ..9 years +/- 17.5) nonrenal failure patients (mean ClCr +/- SD: 76.2 mL/min +/- 29.20) receiving vancomycin therapy for at least 10 days...
  14. pmc The tfdR gene product can successfully take over the role of the insertion element-inactivated TfdT protein as a transcriptional activator of the tfdCDEF gene cluster, which encodes chlorocatechol degradation in Ralstonia eutropha JMP134(pJP4)
    J H Leveau
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Duebendorf
    J Bacteriol 178:6824-32. 1996
    ..It has the highest degree of similarity with the proteins TcbR, ClcR, and TfdR, which are involved in the regulation of chloroaromatic breakdown...
  15. pmc Molecular basis for pancreatitis
    Edwin Thrower
    Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA
    Curr Opin Gastroenterol 24:580-5. 2008
    ..This timely review will focus on clinical and basic science studies that have greatly advanced our knowledge of the molecular mechanisms of both acute pancreatitis and chronic pancreatitis over the last year...
  16. ncbi Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin
    J P Steiner
    Howard Hughes Medical Institute, Durham, North Carolina
    J Biol Chem 263:14417-25. 1988
    ..This flexibility has implications for assembly of the membrane skeleton and targeting of spectrin isoforms to specialized regions of cells...
  17. ncbi Ganciclovir pharmacokinetics and cytokine dynamics in renal transplant recipients with cytomegalovirus infection
    K M Tornatore
    Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University of Buffalo, NY, USA
    Clin Transplant 15:297-308. 2001
    ..A creatinine clearance (ClCr) was generated by the Cockroft-Gault (C-G) equation (range: 42.3-68.5 mL/min) to determine ganciclovir dosing...
  18. ncbi Detrimental effects of controlled reperfusion on renal function after porcine autotransplantation are fully compensated by the use of Carolina rinse solution
    Peter Wamser
    Department of Surgery, University of Vienna, General Hospital, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Transpl Int 16:191-6. 2003
    ..porcine kidney transplantation model and assessed the normal values (control group) for creatinine clearance (ClCr) and urine output per hour (U/h) after "standard" reperfusion similar to clinical transplantation...
  19. pmc The effects of renal impairment on the pharmacokinetics and safety of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole
    Satoshi Sobue
    Clinical Pharmacology, Pfizer Global R and D, Tokyo Laboratories, Pfizer Japan Inc, Tokyo, Japan
    Br J Clin Pharmacol 57:773-84. 2004
    ....
  20. ncbi Serum bicarbonate: can it be a marker of metformin induced acidosis in geriatrics?
    S Rajeshwari
    Department of Pharmacology, Kasturba Medical College and Hospital, Manipal University, Mangalore 575 001, Karnataka, India
    Nepal Med Coll J 11:254-7. 2009
    ..Baseline serum creatinine and bicarbonate were estimated. Creatinine clearance (Clcr ml/ min) was calculated. Patients were grouped into group 1-4 depending upon the doses of metformin they received...
  21. ncbi Influence of renal insufficiency on pharmacokinetics of ACYL-glucuronide metabolite of mycophenolic acid in renal transplant patients
    F M González-Roncero
    Servicio de Nefrologia, Hospitales Universitarios Virgen del Rocio, Sevilla, Spain
    Transplant Proc 39:2176-8. 2007
    ..They were divided between a group with preserved renal function (group I, mean creatinine clearance [Clcr] of 105 +/- 7 mL/min) and one with advanced renal insufficiency (group II, mean Clcr of 27 +/- 5 mL/min)...
  22. ncbi Pharmacokinetics of beta-methyldigoxin in subjects with normal and impaired renal function
    K Tsutsumi
    Department of Clinical Pharmacology and Therapeutics, Oita Medical University, Japan
    J Clin Pharmacol 33:154-60. 1993
    ..The steady-state volume of distribution decreased proportionately as creatinine clearance (CLCR) decreased, although steady-state volume of distribution of hemodialysis patients had large interindividual ..
  23. ncbi [Study of the predictive method of 24-hour creatinine clearance in calculating the appropriate dosage of Carboplatin]
    Rie Hirai
    Department of Pharmacy, Toho University Omori Medical Center, Tokyo, Japan
    Yakugaku Zasshi 128:1209-14. 2008
    ..Instead of the glomerular filtration rate (GFR), 24-h creatinine clearance (24 CLcr) is often used in this formula, which is calculated based on 24-h urine collection in clinical practice.
  24. doi Advances in the etiology of chronic pancreatitis
    Markus M Lerch
    Department of Medicine A, Ernst Moritz Arndt Universitat Greifswald, Greifswald, Germany
    Dig Dis 28:324-9. 2010
    ..subtle risk associations and disease modifiers that can only be identified in large cohort studies, as for the chymotrypsin C, calcium-sensing receptor and the anionic trypsin (PRSS2) mutations...
  25. pmc Disposition of cefmetazole in healthy volunteers and patients with impaired renal function
    C E Halstenson
    Drug Evaluation Unit, Hennepin County Medical Center, Minneapolis, Minnesota 55415
    Antimicrob Agents Chemother 34:519-23. 1990
    ..In six subjects with creatinine clearance (CLCR) of greater than 90 ml/min per 1.73 m2 (group 1), the terminal elimination half-life (t1/2 beta) was 1.31 +/- 0...
  26. pmc The pharmacokinetics of remoxipride and metabolites in patients with various degrees of renal function
    G Movin-Osswald
    Department of Clinical Pharmacology, Astra Arcus AB, Sodertalje, Sweden
    Br J Clin Pharmacol 35:615-22. 1993
    ..Twenty-one patients with severely impaired (ClCr < 25 ml min-1), moderately impaired (ClCr 25-50 ml min-1) and normal (ClCr > 65 ml min-1) renal function were ..
  27. pmc Population pharmacokinetics of platinum after nedaplatin administration and model validation in adult patients
    Toru Ishibashi
    Developmental Research Laboratories, Shionogi and Co, Ltd, Osaka, Japan
    Br J Clin Pharmacol 56:205-13. 2003
    ..The relevant covariates and the extent of inter- and intra-individual variability were evaluated...
  28. ncbi Costs and effectiveness of ultrasonography and limited computed tomography for diagnosing appendicitis in children
    B M Pena
    Department of Medicine, Division of Emergency Medicine, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Pediatrics 106:672-6. 2000
    ..A protocol of ultrasonography (US) followed by computed tomography with rectal contrast (CTRC) has been shown to be 94% accurate in the diagnosis of acute appendicitis in children...
  29. doi Differences in curve behavior after fusion in adolescent idiopathic scoliosis patients with open triradiate cartilages
    Paul D Sponseller
    Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA
    Spine (Phila Pa 1976) 34:827-31. 2009
    ..Retrospective review...
  30. pmc Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells
    Richard Szmola
    Department of Molecular and Cell Biology, Boston University, Henry M Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA
    Gut 59:365-72. 2010
    ..The aim of the present study was to explore whether CTRC mutants induce endoplasmic reticulum (ER) stress in pancreatic acinar cells...
  31. ncbi Plasma glutathione peroxidase activity in the elderly
    K Wieczorowska-Tobis
    Pathophysiology Department, University Medical School, Poznan, Poland
    Int Urol Nephrol 32:463-7. 2001
    ..PGP activity may be used to assess renal function in elderly, we measured the plasma PGP and creatinine clearance (ClCr) in 65 active, community-dwelling elderly (range: 65-93 years; 47 women and 18 men)...
  32. doi Correlation between plasma milrinone concentration and renal function in patients with cardiac disease
    M Hasei
    Intensive Care Unit, Osaka University Hospital, Osaka, Japan
    Acta Anaesthesiol Scand 52:991-6. 2008
    ..The dose of milrinone should be reduced in patients with renal failure. However, there is little data examining the relationship between plasma concentration of milrinone (pCmil) and renal function in intravenous infusion...
  33. ncbi Estimation of glomerular filtration rate in older patients with chronic renal insufficiency: is the modification of diet in renal disease formula an improvement?
    Edmund J Lamb
    Department of Clinical Biochemistry, East Kent Hospitals NHS Trust, Kent and Canterbury Hospital, Canterbury, Kent, United Kingdom
    J Am Geriatr Soc 51:1012-7. 2003
    ..To evaluate a new formula for glomerular filtration rate (GFR), derived from the Modification of Diet in Renal Disease (MDRD) study in older people...
  34. ncbi Protective effects of fosfomycin on cisplatin-induced nephrotoxicity in patients with lung cancer
    N Rojanasthien
    Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Thailand
    Int J Clin Pharmacol Ther 39:121-5. 2001
    ..urinary N-acetyl-beta-D-glucosaminidase (NAG) activity, serum creatinine (Scr) and creatinine clearance (Clcr) were determined the day before and at day 3 and day 6 after cisplatin administration...
  35. ncbi The pharmacokinetics and pharmacodynamics of fludarabine phosphate in patients with renal impairment: a prospective dose adjustment study
    Stuart M Lichtman
    Don Monti Division of Medical Oncology, North Shore University Hospital NYU School of Medicine, 300 Community Drive, Manhasset, NY 11030, USA
    Cancer Invest 20:904-13. 2002
    ..one week later by five (one per day) doses that were adjusted according to three predefined creatinine clearance (CLcr) levels...
  36. ncbi Predictive performance of ten equations for estimating creatinine clearance in cardiac patients. Iohexol Cooperative Study Group
    S A Spinler
    Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19104, USA
    Ann Pharmacother 32:1275-83. 1998
    The predictive performance of 10 equations used to estimate creatinine clearance (Clcr) was assessed retrospectively from data collected on 420 patients.
  37. ncbi Gastrointestinal disease control after histamine2-receptor antagonist dose modification for renal impairment in frail chronically ill elderly patients
    Thomas E Lackner
    University of Minnesota, College of Pharmacy and Institute for the Study of Geriatric Pharmacotherapy, Minneapolis, USA
    J Am Geriatr Soc 51:650-6. 2003
    ..To determine whether histamine2-receptor antagonist (H2RA) dose modified for renal impairment affects gastrointestinal (GI) disease control...
  38. pmc Factors influencing elimination and distribution of fleroxacin: metaanalysis of individual data from 10 pharmacokinetic studies
    B G Reigner
    Department of Clinical Pharmacology, F Hoffmann La Roche Ltd, Basel, Switzerland
    Antimicrob Agents Chemother 40:575-80. 1996
    ..The covariates investigated were predicted creatinine clearance (CLCR), age, gender, body surface area, body weight, and lean body weight (LBW). The predicted CL/F and V/F were 83...
  39. ncbi Molecular cloning and expression of serum calcium-decreasing factor (caldecrin)
    A Tomomura
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    J Biol Chem 270:30315-21. 1995
    ..13 amino acids, and is, with the exception of a central region, almost identical to the reported rat pancreatic elastase IV sequence. The caldecrin gene is selectively expressed in the pancreas, as judged by Northern blot analysis...
  40. ncbi Teicoplanin population pharmacokinetic analysis in hospitalized patients
    Dolors Soy
    Pharmacy Service UASP, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain
    Ther Drug Monit 28:737-43. 2006
    ..Demographic and biologic data creatinine clearance (CLcr), weight (WT), and albumin (Alb) were tested for inclusion as covariates in the basic model...
  41. doi Effect of glycemic load on peptide-YY levels in a biracial sample of obese and normal weight women
    Kimberly A Brownley
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 18:1297-303. 2010
    ....
  42. ncbi [Cystatin C as a marker of glomerular filtration rate in patients with ovarian cancer]
    Lubomir Bodnar
    Wojskowy Instytut Medyczny w Warszawie, CSK MON Klinika Onkologii
    Pol Merkur Lekarski 24:307-11. 2008
    ..THE AIM OF STUDY We investigated significance of cystatin C in assessment of GFR and its influence on overall survival (OS) in patients with ovarian cancer (OC)...
  43. ncbi Disposition and safety of omapatrilat in subjects with renal impairment
    D A Sica
    Medical College of Virginia of Virginia Commonwealth University, Richmond 23298, USA
    Clin Pharmacol Ther 68:261-9. 2000
    ..Omapatrilat, a vasopeptidase inhibitor, preserves natriuretic peptides and inhibits the renin angiotensin aldosterone system by simultaneously inhibiting neutral endopeptidase and angiotensin-converting enzyme...
  44. pmc Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis
    Andrea Schnúr
    Department of Molecular and Cell Biology, Henry M Goldman School of Dental Medicine, Boston University, Boston, Massachusetts, USA
    Gut 63:337-43. 2014
    ..caused by mutations in human cationic trypsinogen (PRSS1) which lead to increased autoactivation by altering chymotrypsin C (CTRC)-dependent trypsinogen activation and degradation...
  45. ncbi Early endotoxin-mediated haemostatic and inflammatory responses in the clopidogrel-treated pig
    Miklos Lipcsey
    Section of Anaesthesiology and Critical Care, Department of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Platelets 16:408-14. 2005
    ..Although renal function, as evaluated by creatinine clearance (CLcr) deteriorated significantly (P = 0...
  46. ncbi The value of contrast-enhanced helical CT scan with rectal contrast enema in the diagnosis of acute appendicitis
    Lena N Naffaa
    Department of Diagnostic Radiology, American University of Beirut Medical Center, PO Box 11 0236, Beirut, Lebanon
    Clin Imaging 29:255-8. 2005
    ....
  47. ncbi Incidence of renal insufficiency in cancer patients
    Ekrem Dogan
    Department of Internal Medicine, Yuzuncu Yil University, Van, Turkey
    Adv Ther 22:357-62. 2005
    ..1%) of the patients had an estimated GFR <90 mL/min. Among these, the Clcr was between 60 and 89 mL/min in 241 patients (19.8%); 30 and 59 mL/min in 75 patients (6...
  48. ncbi Population pharmacokinetics of higher-dose mizoribine in healthy male volunteers
    Mutsuko Honda
    Graduate School of Pharmaceutical Sciences, University of Toyama, Japan
    Biol Pharm Bull 29:2460-4. 2006
    ..349 h, 0.869 h-1, and 0.834 l/kg, respectively. Oral clearance (CL/F) was modeled with creatinine clearance (CLcr), and the mean value was estimated to be 1.93.CLcr l/h...
  49. pmc Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop
    Balázs Csaba Németh
    Department of Molecular and Cell Biology, Boston University Henry M Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 288:24049-62. 2013
    b>Chymotrypsin C (CTRC) is a proteolytic regulator of trypsinogen autoactivation in humans...
  50. pmc Pharmacokinetics of zanamivir following intravenous administration to subjects with and without renal impairment
    Stephen Weller
    GlaxoSmithKline, Research Triangle Park, North Carolina, USA
    Antimicrob Agents Chemother 57:2967-71. 2013
    ..were assessed by regression analysis of systemic clearance (CL) and CLR as a function of creatinine clearance (CLCR)...
  51. doi Pharmacokinetics of ertapenem in burns patients
    E Dailly
    Clinical Pharmacology Department, CHU de Nantes, Nantes, France
    Int J Antimicrob Agents 42:48-52. 2013
    ..These first results support that the ERT plasma concentration should be closely monitored particularly for patients with high values of BSA and/or CL(Cr) to avoid suboptimal exposure...
  52. doi Characterization of two deletions of the CTRC locus
    Emmanuelle Masson
    Institut National de la Sante et de la Recherche Medicale INSERM, U1078, Brest, France
    Mol Genet Metab 109:296-300. 2013
    ..The CTRC-deleting complex rearrangement probably resulted from LINE-1-mediated Alu insertion, which represents a novel mutational mechanism causing chronic pancreatitis...
  53. ncbi Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1
    Dan Su
    Department of Biochemistry, University of Nebraska Lincoln, Lincoln, Nebraska 68588, USA
    Biochemistry 43:12177-88. 2004
    ..Our data also suggest that various N-terminal extensions in mammalian TRs are often expressed in testes...
  54. ncbi Competition between IL-1, IL-1ra and TGF-beta 1 modulates the response of the ELA4.NOB-1/CTLL bioassay: implications for clinical investigations
    P Ashwood
    Gastrointestinal Laboratory, The Rayne Institute, St Thomas Hospital, London SE1 7EH, United Kingdom
    Inflamm Res 53:60-5. 2004
    ..The net effect of these cytokines, rather than IL-1 levels, are frequently suggested to regulate tissue inflammation, but confirming this has been difficult...
  55. ncbi Correlation of antifactor Xa concentrations with renal function in patients on enoxaparin
    Sheryl L Chow
    University at Buffalo, State University of New York, Kaleida Health Systems, Buffalo, New York, USA
    J Clin Pharmacol 43:586-90. 2003
    ..The median antifactor Xa levels were higher in patients with creatinine clearance (CLCr) < or = 30 mL/min compared to CLCr > or = 31 mL/min (1.34 IU/mL vs. 0.91 IU/mL, respectively, p < 0.05)...
  56. doi Successful treatment of patients with multiple myeloma and impaired renal function with lenalidomide: results of 4 German centers
    Katharina Oehrlein
    Division of Hematology, Oncology and Immunology, Medical Department, University Hospital of Tubingen, Tubingen, Germany
    Clin Lymphoma Myeloma Leuk 12:191-6. 2012
    ..Analysis showed myeloma overall response rate of 84%, with 42% of patients with improvement of renal function. Lenalidomide/dexamethasone is highly effective, with acceptable toxicity in the renally impaired patient group...
  57. pmc Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen
    Andras Szabo
    Department of Molecular and Cell Biology, Boston University Henry M Goldman School of Dental Medicine, Boston, MA 02118, USA
    FEBS J 279:4283-92. 2012
    The pancreatic serine protease chymotrypsin C (CTRC) cleaves the Leu81-Glu82 peptide bond in the calcium-binding loop of human cationic trypsinogen and thereby promotes its degradation...
  58. ncbi Frequent expression of haemopoietic and non-haemopoietic antigens by neoplastic plasma cells: an immunohistochemical study using formalin-fixed, paraffin-embedded tissue
    U R Petruch
    Institute of Pathology, Eberhard Karls University, Tubingen, Germany
    Histopathology 20:35-40. 1992
    ..Lack of awareness of the frequent expression of both haemopoietic and non-haemopoietic antigens by neoplastic plasma cells could lead to mis-diagnosis of plasmacytomas as malignant lymphomas or even as carcinomas or sarcomas...
  59. pmc A phase 1 study to evaluate the effect of dolutegravir on renal function via measurement of iohexol and para-aminohippurate clearance in healthy subjects
    Justin Koteff
    ViiV Healthcare, Research Triangle Park, North Carolina, USA
    Br J Clin Pharmacol 75:990-6. 2013
    ..The effect of DTG on glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and creatinine clearance (CLcr ) was evaluated in 34 healthy volunteers.
  60. doi Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients
    T Aoyama
    Laboratory of Clinical Pharmacokinetics, School of Pharmacy, Nihon University, Chiba, Japan
    J Clin Pharm Ther 37:356-63. 2012
    ....
  61. pmc A conservative assessment of the major genetic causes of idiopathic chronic pancreatitis: data from a comprehensive analysis of PRSS1, SPINK1, CTRC and CFTR genes in 253 young French patients
    Emmanuelle Masson
    Institut National de la Sante et de la Recherche Medicale, U1078, Brest, France
    PLoS ONE 8:e73522. 2013
    ....
  62. doi Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants
    Sumit Paliwal
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India
    Gut 62:1602-6. 2013
    ..Recently, chymotrypsin C (CTRC) variants that diminish its activity or secretion were found to predict susceptibility to chronic ..
  63. ncbi Zea mays L. extracts modify glomerular function and potassium urinary excretion in conscious rats
    D V O Velazquez
    Departamento de Fisiologia e Farmacologia UFPE, s n Cidade Universitária, Recife, PE, Brasil
    Phytomedicine 12:363-9. 2005
    ..in the IMC for 3 h (Protocol 2). Clcr (294.6 +/- 73.2, n = 12, to 241.7 +/- 48.0 microl/ min/100 g body wt.; n = 13; p<0...
  64. doi Pharmacokinetic study of S-1 in patients in whom inulin clearance was measured
    Yuichi Ando
    Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi, Japan
    Oncology 83:38-44. 2012
    ....
  65. ncbi Evaluation of once daily tobramycin dosing in critically ill patients through Bayesian simulation
    J F Peris-Marti
    Pharmacy Service, Centro Sociosanitario La Florida Alicante, Alicante, Spain
    J Clin Pharm Ther 29:65-70. 2004
    To evaluate if once-daily dose (ODD) regimens of tobramycin attain pharmacodynamic goals using individualized pharmacokinetic monitoring of critically ill patients with creatinine clearance (Clcr) over 60 mL/min.
  66. ncbi [Utility of cystatin-C in hospitalized patients. Comparing with different methods of assessing renal function]
    F J Cepeda
    Nefrologia 27:168-74. 2007
    ..to assessing renal function, even though limitations, some time is necessary measure 24 h creatinine clearance (CLcr), or estimate Cockroft-Gault (C-G) or MDRD formulas...
  67. pmc Comparison of Measured Creatinine Clearance and Clearances Estimated by Cockcroft-Gault and MDRD Formulas in Patients with a Single Kidney
    Sebastiao Rodrigues Ferreira-Filho
    Medical School, Federal University of Uberlandia, Uberlandia MG, Brazil
    Int J Nephrol 2011:626178. 2011
    ..comparable to the more traditional formula used to obtain the creatinine clearance from a 24-hour urine collection (ClCr(m)), particularly in patients with only one kidney...
  68. ncbi Influence of renal impairment on the pharmacokinetics of oral roflumilast: an open-label, parallel-group, single-center study
    T D Bethke
    Nycomed GmbH, Konstanz, Germany
    Int J Clin Pharmacol Ther 49:491-9. 2011
    ..The potential impact of renal impairment on the pharmacokinetics of roflumilast and its active main metabolite roflumilast N-oxide were characterized...
  69. ncbi Hyperoxia-induced protection against rat's renal ischemic damage: relation to oxygen exposure time
    Hannaneh Wahhabaghai
    Trauma Research Center, Baqiyatallah University of Medical Sciences, Teheran, Iran
    Ren Fail 31:514-21. 2009
    ..In the present study, we investigated whether oxygen pretreatment induces delayed renal protection in rats. The possible role of some renal antioxidant agents was also investigated...
  70. pmc Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma
    Byung Hee Koh
    Department of Life Science, Sogang University, Seoul 121 742, Korea
    Proc Natl Acad Sci U S A 107:10614-9. 2010
    ..To examine the in vivo function of Th2 LCR, we generated CD4-specific Th2 LCR-deficient (cLCR KO) mice using Cre-LoxP recombination...
  71. doi Single-dose gentamicin clearance is a predictor of creatinine clearance in spinal man
    Jack L Segal
    Department of Medicine, Los Angeles County, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA
    Am J Ther 17:390-5. 2010
    ..To incorporate SCI population-specific patient variables into a predictive model for estimating CLcr and GFR. A retrolective study of gentamicin clearance as a measure of GFR in patients with SCI...
  72. pmc Low bone mineral density and its predictors in type 1 diabetic patients evaluated by the classic statistics and artificial neural network analysis
    Cristina Eller-Vainicher
    Department of Medical Sciences, University of Milan, Endocrinology and Diabetology Unit, Fondazione IRRCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Diabetes Care 34:2186-91. 2011
    ..To investigate factors associated with bone mineral density (BMD) in type 1 diabetes by classic statistic and artificial neural networks...
  73. pmc Chymotrypsin C (caldecrin) is associated with enamel development
    R S Lacruz
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, USA
    J Dent Res 90:1228-33. 2011
    ..enamel organ cells derived from the secretory and maturation stages of amelogenesis, the serine protease chymotrypsin C (caldecrin, Ctrc) was identified as significantly up-regulated (> 11-fold) during enamel maturation...
  74. doi Chronic pancreatitis: genetics and pathogenesis
    Jian Min Chen
    Institut National de la Sante et de la Recherche Medicale INSERM, U613, Brest, France
    Annu Rev Genomics Hum Genet 10:63-87. 2009
    ....
  75. pmc Serum calcium-decreasing factor, caldecrin, inhibits osteoclast differentiation by suppression of NFATc1 activity
    Hiroya Hasegawa
    Division of Biochemistry, Department of Oral Biology and Tissue Engineering, Meikai University, School of Dentistry, 1 1 Keyakidai, Sakado, Saitama 350 0283, Japan
    J Biol Chem 285:25448-57. 2010
    Caldecrin/chymotrypsin C is a novel secretory-type serine protease that was originally isolated as a serum calcium-decreasing factor from the pancreas...
  76. pmc Population pharmacokinetic analysis of varenicline in adult smokers
    Patanjali Ravva
    Global Pharmacometrics, Primary Care Business Unit, Worldwide Pharmaceutical Operations, Pfizer Inc, New London, Connecticut 06320, USA
    Br J Clin Pharmacol 68:669-81. 2009
    ..To characterize the population pharmacokinetics of varenicline and identify factors leading to its exposure variability in adult smokers...
  77. doi Purification, cDNA cloning, and recombinant expression of chymotrypsin C from porcine pancreas
    Haibo Wang
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Acta Biochim Biophys Sin (Shanghai) 43:568-75. 2011
    b>Chymotrypsin C is a bifunctional secretory-type serine protease in pancreas; besides proteolytical activity, it also exhibits a calcium-decreasing activity in serum...
  78. pmc Functional and structural characterization of polysaccharide co-polymerase proteins required for polymer export in ATP-binding cassette transporter-dependent capsule biosynthesis pathways
    Kane Larue
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Biol Chem 286:16658-68. 2011
    ..These experiments add further support for the model of an ABC transporter-PCP-OPX multiprotein complex that functions to export CPS across the cell envelope...
  79. doi Genetic basis of chronic pancreatitis in Asia Pacific region
    D Nageshwar Reddy
    Asian Healthcare Foundation, Asian Institute of Gastroenterology, Somajiguda, Hyderabad, Andhra Pradesh, India
    J Gastroenterol Hepatol 26:2-5. 2011
    ..Cathepsin B (CTSB) is also found to be associated with TCP. However mutations in cationic and anionic trypsinogen gene do not play an important role in causing CP in Asia Pacific region...
  80. doi Changes in the pharmacokinetics of digoxin in polyuria in streptozotocin-induced diabetic mice and lithium carbonate-treated mice
    Nobutomo Ikarashi
    Hoshi University, Department of Clinical Pharmacokinetics, Tokyo, Japan
    Xenobiotica 41:486-93. 2011
    ..1 times for normal mice and 1.6 times for STZ mice. Creatinine clearance (CLcr) and the renal mRNA expression levels of mdr1a did not differ significantly between the normal, STZ, and Li(2)CO(3)-..
  81. doi Population pharmacokinetics of pregabalin in healthy subjects and patients with chronic pain or partial seizures
    Howard N Bockbrader
    Neurosciences, Clinical Pharmacology, Pfizer Global Research and Development, New London, Connecticut 06320, USA
    Epilepsia 52:248-57. 2011
    ..The present study investigated the population pharmacokinetics of pregabalin following single and multiple doses in healthy volunteers and patient populations...
  82. doi Genetics of pancreatitis: a guide for clinicians
    Heiko Witt
    Department of Pediatrics, Technische Universität München TUM, Munich, Germany
    Dig Dis 28:702-8. 2010
    ..Approximately 15-40% of patients with so-called idiopathic CP carry p.N34S on one allele or on both alleles. Chymotrypsin C (CTRC) degrades all human trypsin isoforms with high specificity. Two CTRC alterations, p.R254W and p...
  83. doi Correlation of bivalirudin dose with creatinine clearance during treatment of heparin-induced thrombocytopenia
    Courtney L Runyan
    Departments of Pharmacy, Maine Medical Center, Portland, Maine 04102, USA
    Pharmacotherapy 31:850-6. 2011
    ..To evaluate steady-state bivalirudin dosing requirements in patients with a wide range of kidney function who were being treated for heparin-induced thrombocytopenia (HIT)-related disorders...
  84. ncbi Steady state pharmacokinetics and dose equivalents of oral clodronate in renal failure
    S Makela
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Int J Clin Pharmacol Ther 49:128-36. 2011
    ..Clodronate is used in the treatment of osteoporosis, and malignancy-associated bone disease. The steady state pharmacokinetics and the dose equivalents of oral clodronate were assessed in subjects with various degrees of renal failure...
  85. doi Effect of chymotrypsin C and related proteins on pancreatic cancer cell migration
    Haibo Wang
    Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Acta Biochim Biophys Sin (Shanghai) 43:362-71. 2011
    Pancreatic cancer is a malignant cancer with a high mortality rate. The amount of chymotrypsin C in pancreatic cancer cells is only 20% of that found in normal cells...
  86. doi Lenalidomide in combination with dexamethasone: effective regimen in patients with relapsed or refractory multiple myeloma complicated by renal impairment
    Ulrike Klein
    Department of Internal Medicine V, Hematology and Oncology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Ann Hematol 90:429-39. 2011
    ..The baseline creatinine clearance (CLCr) was normal in 94 patients (CLCr≥80 ml/min), while RI was observed in 73 patients, including 40 patients with ..
  87. pmc High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues
    Andras Szabo
    Department of Molecular and Cell Biology, Boston University Henry M Goldman School of Dental Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 286:22535-45. 2011
    Human chymotrypsin C (CTRC) is a pancreatic protease that participates in the regulation of intestinal digestive enzyme activity...
  88. doi Estimating the glomerular filtration rate in obese adult patients for drug dosing
    Manjunath P Pai
    Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, NY 12208, USA
    Adv Chronic Kidney Dis 17:e53-62. 2010
    ..However, drug dosing guidelines are often based on creatinine clearance (CLcr) using the Cockcroft-Gault equation as a surrogate of GFR...
  89. doi Impact of administration of vancomycin or linezolid to critically ill patients with impaired renal function
    O Rodriguez Colomo
    Department of Intensive Medicine, Hospital Clinico Universitario, Valencia, Spain
    Eur J Clin Microbiol Infect Dis 30:635-43. 2011
    ..2%) vs. 25 (31.6%); p = 0.007], septic shock [39 (57.4%) vs. 60 (75.9%); p = 0.013] and greater RF (mean ClCr 42.24 ml/min vs. 37.57 ml/min; p = 0.04)...
  90. ncbi Pharmacokinetics of oral cefatrizine in patients with impaired renal function
    W Couet
    CEMAF, Poitiers, France
    Int J Clin Pharmacol Ther Toxicol 29:213-7. 1991
    ..function, as indicated by the significant correlations between apparent clearance (Cl/F) and creatinine clearance (Clcr), and between renal clearance (Clr) and creatinine clearance (Clcr)...
  91. ncbi New features of renal lesion induced by stroma free hemoglobin
    W L Chan
    Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
    Toxicol Pathol 28:635-42. 2000
    ..The low dose (0.03 g) of SFH infusion did not alter the creatinine clearance (Clcr) over 10 days. The Clcr decreased in rats receiving 0.48 g SFH but fully recovered at day 10...
  92. ncbi Determination of amino acid sequence responsible for suppression of bone resorption by serum calcium-decreasing factor (caldecrin)
    A Tomomura
    Department of Biochemistry, Meikai University School of Dentistry, 1 1 Keyakidai, Saitama 350 0283, Sakado, Japan
    FEBS Lett 508:454-8. 2001
    We previously reported on the serum calcium-decreasing activity of recombinant protein factor referred to as caldecrin [Tomomura et al. (1995) J. Biol. Chem. 270, 30315-30321]...
  93. ncbi Rat brain expresses serum calcium-decreasing factor (caldecrin)
    Akito Tomomura
    Department of Biochemistry, Meikai University School of Dentistry, 1 1 Keyakidai, Sakado, Saitama 350 0283, Japan
    Neurosci Lett 317:17-20. 2002
    We previously cloned the serum calcium-decreasing factor referred to as caldecrin from pancreas (J. Biol. Chem. 270 (1995) 30315)...
  94. pmc Pharmacokinetics of moxifloxacin, a novel 8-methoxy-quinolone, in patients with renal dysfunction
    H Stass
    Bayer AG, Clinical Pharmacology, Wuppertal and Clin Pharma Research AG, Kiel, Germany
    Br J Clin Pharmacol 53:232-7. 2002
    ..To evaluate the influence of impaired renal function on the plasma and urinary pharmacokinetics of moxifloxacin, a novel 8-methoxy-quinolone antibacterial drug...
  95. pmc The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil
    Gary J Muirhead
    Clinical Sciences, Pfizer Central Research, Sandwich, Kent, UK
    Br J Clin Pharmacol 53:21S-30S. 2002
    ..To investigate the effects of age and renal and hepatic impairment on the pharmacokinetics, tolerability and safety of sildenafil (single 50-mg oral dose) and its major circulating N-desmethyl metabolite, UK-103,320...
  96. ncbi Analysis of organophosphorus compound adducts of serine proteases by liquid chromatography-tandem mass spectrometry
    Kouichiro Tsuge
    National Research Institute of Police Science, 6 3 1, Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 776:79-88. 2002
    ..Thus, the phosphorylation site in alpha-chymotrypsin could be unequivocally identified to be at the serine residue which is located at position 47, from the N-terminus of the alpha-chymotrypsin C-chain.
  97. ncbi Pentostatin pharmacokinetics and dosing recommendations in patients with mild renal impairment
    Chetan Lathia
    Bayer Corporation, 400 Morgan Lane, West Haven, CT 06516, USA
    Cancer Chemother Pharmacol 50:121-6. 2002
    ..The purpose of this study was to determine the pharmacokinetic parameters of pentostatin in renally impaired patients in order to establish dosing guidelines for this population...
  98. ncbi Estimating the genetic component (RGC) in pharmacokinetic variability of the antiretroviral didanosine among healthy Brazilians
    Luciane S Velasque
    Programa de Computacao Cientifica, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    AIDS 19:S76-80. 2005
    ..Our work expands on a previous reported method known as RGC...
  99. ncbi Effect of renal impairment on the pharmacokinetics of cilostazol and its metabolites
    S Mallikaarjun
    Department of Clinical Pharmacokinetics Pharmacodynamics and Metabolism, Otsuka America Pharmaceutical, Inc, Rockville, MD 20850, USA
    Clin Pharmacokinet 37:33-40. 1999
    ..The pharmacokinetics of cilostazol were studied in patients with mild, moderate and severe renal impairment and in healthy volunteers after administration of 50 mg single and multiple doses of cilostazol...
  100. ncbi Ultrasonography and limited computed tomography in the diagnosis and management of appendicitis in children
    B M Garcia Peña
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 282:1041-6. 1999
    ....

Research Grants70

  1. MICROBIAL DEGRADATION OF AGENT ORANGE
    Ananda Chakrabarty; Fiscal Year: 2000
    ..With regard to the evolution of the clc genes, he plans to examine how the regulatory protein ClcR, which regulates positively the expression of the clcABD(F) operon, binds the promoter region of the operon and ..
  2. SOUTHWEST ONCOLOGY GROUP - OPERATIONS OFFICE
    Laurence Baker; Fiscal Year: 2007
    ..PERFORMANCE Orqanization City State CTRC Foundation San Antonio TX Southwest Oncology Group Operations Office San Antonio TX (the remaining ..
  3. Chymotrypsin C in pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2009
    The specific objectives of the present grant proposal are to determine the role of chymotrypsin C (CTRC) in the regulation of digestive enzyme activation and degradation and to investigate the mechanism(s) by which CTRC mutants act as ..
  4. Chymotrypsin C in pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2010
    The specific objectives of the present grant proposal are to determine the role of chymotrypsin C (CTRC) in the regulation of digestive enzyme activation and degradation and to investigate the mechanism(s) by which CTRC mutants act as ..
  5. Chymotrypsin C in pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2009
    The specific objectives of the present grant proposal are to determine the role of chymotrypsin C (CTRC) in the regulation of digestive enzyme activation and degradation and to investigate the mechanism(s) by which CTRC mutants act as ..
  6. DOSAGE COMPENSATION OF THE ACTIVE X CHROMOSOME IN MAMMALS
    Christine M Disteche; Fiscal Year: 2010
    ..using a mouse model in which we have previously shown a doubling of expression from the chloride channel gene, Clcr>4, when it is located on the X compared to an autosome...
  7. DOSAGE COMPENSATION OF THE ACTIVE X CHROMOSOME IN MAMMALS
    Christine Disteche; Fiscal Year: 2007
    ..using a mouse model in which we have previously shown a doubling of expression from the chloride channel gene, Clcr>4, when it is located on the X compared to an autosome...
  8. Chymotrypsin C in pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2009
    ..This competitive revision grant proposes to identify novel peptide inhibitors for the digestive enzyme chymotrypsin C. The parent grant investigates how chymotrypsin C regulates activation and degradation of other digestive ..
  9. Regulation of Capsule Biosynthesis in N. meningitidis
    David Stephens; Fiscal Year: 2006
    ....
  10. CLEK STUDY CORNEAL TOPOGRAPHY READING CENTER
    Timothy McMahon; Fiscal Year: 2004
    ..This proposal seeks support for a period of five years to provide for salaries, equipment, computer programming support, consultants, supplies and travel. ..
  11. In home closed loop reduction of nocturnal hypoglycemia and daytime hyperglycemia
    H Peter Chase; Fiscal Year: 2010
    ..This research is focused on reducing hypoglycemia as well as hyperglycemia after meals in people with type 1 diabetes. Hopefully this will lead to improved glycemic control for participants. ..
  12. Evaluating Cancer Disparities Among Hispanic Communities
    Yadvindera Bains; Fiscal Year: 2005
    ..This proposal will yield invaluable data and information on cancer outcomes and treatment strategies to improve cancer morbidity and mortality outcomes in Hispanic populations. ..
  13. SAN ANTONIO CANCER INSTITUTE
    Tyler Curiel; Fiscal Year: 2005
    ....
  14. SAN ANTONIO CANCER INSTITUTE
    Tyler Curiel; Fiscal Year: 2007
    ..abstract_text> ..
  15. Planning for Clinical Translational Science Award
    Barbara Conley; Fiscal Year: 2006
    ....