Gene Symbol: CALCRL
Description: calcitonin receptor like receptor
Alias: CGRPR, CRLR, calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, calcitonin receptor-like
Species: human
Products:     CALCRL

Top Publications

  1. Hilairet S, Belanger C, Bertrand J, Laperriere A, Foord S, Bouvier M. Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. J Biol Chem. 2001;276:42182-90 pubmed
    The calcitonin receptor-like receptor (CRLR) is a seven-transmembrane domain (7TM) protein that requires the receptor activity-modifying protein 1 (RAMP1) to be expressed at the cell surface as a functional calcitonin gene-related peptide ..
  2. Hasdemir B, Bunnett N, Cottrell G. Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor. J Biol Chem. 2007;282:29646-57 pubmed
    ..The ultimate sorting decision to degradative or recycling pathways appears to occur downstream from HRS. ..
  3. McLatchie L, Fraser N, Main M, Wise A, Brown J, Thompson N, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998;393:333-9 pubmed
    ..Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family ..
  4. Evans B, Rosenblatt M, Mnayer L, Oliver K, Dickerson I. CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. J Biol Chem. 2000;275:31438-43 pubmed
    ..A candidate CGRP receptor named calcitonin receptor-like receptor (CRLR) has been identified, and in this study RCP co-immunoprecipitated with CRLR indicating that these two proteins ..
  5. Aiyar N, Disa J, Pullen M, Nambi P. Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells. Mol Cell Biochem. 2001;224:123-33 pubmed
    ..peptides, initiate their biological responses through their interaction with calcitonin receptor-like receptor (CRLR)...
  6. Cottrell G, Padilla B, Pikios S, Roosterman D, Steinhoff M, Grady E, et al. Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. J Biol Chem. 2007;282:12260-71 pubmed
    ..After sustained stimulation, CLR and RAMP1 traffic from endosomes to lysosomes by ubiquitin-independent mechanisms, where they are degraded at different rates. ..
  7. Heroux M, Hogue M, Lemieux S, Bouvier M. Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1. J Biol Chem. 2007;282:31610-20 pubmed
  8. Cao D, Liu X, Guo X, Cong Y, Huang J, Mao Z. Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. Mol Vis. 2009;15:2202-8 pubmed
    To determine whether the polymorphisms of calcitonin receptor-like receptor gene (CALCRL) are associated with primary angle closure glaucoma (PACG) in a southern Chinese population.
  9. Barwell J, Miller P, Donnelly D, Poyner D. Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor. Peptides. 2010;31:170-6 pubmed publisher
    ..Ile32, Gly35 and Thr37 form a separate cluster of residues which modulate CGRP binding. The results from this study may be applicable to other family B GPCRs which can associate with RAMPs. ..

More Information

Publications129 found, 100 shown here

  1. ter Haar E, Koth C, Abdul Manan N, Swenson L, Coll J, Lippke J, et al. Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure. 2010;18:1083-93 pubmed publisher
  2. Barwell J, Conner A, Poyner D. Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. Biochim Biophys Acta. 2011;1813:1906-16 pubmed publisher
    ..Identification of several crucial functional loci gives further insight into the activation mechanism of this complex receptor system and may aid rational drug design. ..
  3. Kusano S, Kukimoto Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, et al. Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. Protein Sci. 2012;21:199-210 pubmed publisher
    The calcitonin receptor-like receptor (CRLR), a class B GPCR, forms a heterodimer with receptor activity-modifying protein 2 (RAMP2), and serves as the adrenomedullin (AM) receptor to control neovascularization, while CRLR and RAMP1 form ..
  4. Kuwasako K, Shimekake Y, Masuda M, Nakahara K, Yoshida T, Kitaura M, et al. Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling. J Biol Chem. 2000;275:29602-9 pubmed
    Expression of the calcitonin receptor-like receptor (CRLR) and its receptor activity modifying proteins (RAMPs) can produce calcitonin gene-related peptide (CGRP) receptors (CRLR/RAMP1) and adrenomedullin (AM) receptors (CRLR/RAMP2 or -3)...
  5. Wu Y, Song S, Liu H, Xing D, Wang X, Fei Y, et al. Role of adrenomedullin in the cerebrospinal fluid-contacting nucleus in the modulation of immobilization stress. Neuropeptides. 2015;51:43-54 pubmed publisher
    ..Immunohistochemical experiments showed that ADM-like immunoreactivity and the calcitonin receptor-like receptor (CRLR) marker were localized in the CSF-contacting nucleus...
  6. Gong B, Zhang H, Huang L, Chen Y, Shi Y, Tam P, et al. Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis. Genet Med. 2019;: pubmed publisher
    ..Mutant RAMP2s aggregated in transfected cells and resulted in damage to the AM-RAMP2/CRLR-cAMP signaling pathway. Ablation of one Ramp2 allele led to cAMP reduction and retinal ganglion cell death in mice...
  7. Aiyar N, Rand K, Elshourbagy N, Zeng Z, Adamou J, Bergsma D, et al. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. J Biol Chem. 1996;271:11325-9 pubmed
    ..Exposure of these cells to CGRP resulted in a 60-fold increase in cAMP production, which was inhibited in a competitive manner by the CGRP1 receptor antagonist, CGRP-(8-37). ..
  8. Deng B, Zhang S, Miao Y, Han Z, Zhang X, Wen F, et al. Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin. J Exp Clin Cancer Res. 2012;31:19 pubmed publisher
    ..Exogenous AM and small interfering RNA (siRNA) specific for AM receptor CRLR were treated to EOC cell line HO8910...
  9. Muschter D, Beiderbeck A, Späth T, Kirschneck C, Schröder A, Grassel S. Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages. Int J Mol Sci. 2019;20: pubmed publisher
    ..similar to chondrocytes, and if alpha-calcitonin gene-related peptide (αCGRP) and the CGRP receptor (CRLR/Ramp1) show comparable activity. Murine RAW264...
  10. Passaglia P, Gonzaga N, Tirapelli D, Tirapelli L, Tirapelli C. Pharmacological characterisation of the mechanisms underlying the relaxant effect of adrenomedullin in the rat carotid artery. J Pharm Pharmacol. 2014;66:1734-46 pubmed publisher
    ..Protein and mRNA expression of AM, calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP)1, 2, 3 were detected in carotid segments from male Wistar rats...
  11. Watkins H, Walker C, Ly K, Bailey R, Barwell J, Poyner D, et al. Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology. Br J Pharmacol. 2014;171:772-88 pubmed publisher
    ..RAMP3 appears to alter the role of specific residues at the CLR-RAMP interface compared with RAMP1 and RAMP2. ..
  12. Figueira L, Israel A. Cerebellar Adrenomedullinergic System. Role in Cardiovascular Regulation. Adv Exp Med Biol. 2017;956:541-560 pubmed publisher
    ..AM) is a multifunctional peptide which exerts numerous biological activities through the activation of AM1 (CRLR?+ RAMP2) and AM2 (CRLR?+?RAMP3) receptors...
  13. Liu X, Liu H, Xiong Y, Yang L, Wang C, Zhang R, et al. Postmenopausal osteoporosis is associated with the regulation of SP, CGRP, VIP, and NPY. Biomed Pharmacother. 2018;104:742-750 pubmed publisher
    ..P (SP) and tachykinin receptor 1 (TACR1), calcitonin gene-related peptide (CGRP) and calcitonin receptor-like (CALCRL), vasoactive intestinal polypeptide (VIP) and receptor 1 and 2 (VPAC1, 2), neuropeptide Y (NPY) and receptor Y1 ..
  14. Wan Y, Ceci L, Wu N, Zhou T, Chen L, Venter J, et al. Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes. Lab Invest. 2019;: pubmed publisher
    ..There was enhanced hepatic expression of Calca (coding α-CGRP) and the CGRP receptor components (CRLR, RAMP-1 and RCP) in BDL and in both WT α-CGRP-/- and BDL α-CGRP-/- mice, respectively...
  15. Gangula P, Chauhan M, Reed L, Yallampalli C. Age-related changes in dorsal root ganglia, circulating and vascular calcitonin gene-related peptide (CGRP) concentrations in female rats: effect of female sex steroid hormones. Neurosci Lett. 2009;454:118-23 pubmed publisher
    ..We also examined whether vascular CGRP receptor components, calcitonin receptor like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1) are elevated by sex steroid hormones ..
  16. Suekane A, Saito Y, Nakahata S, Ichikawa T, Ogoh H, Tsujikawa K, et al. CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis. Sci Rep. 2019;9:429 pubmed publisher
    ..Since we previously identified high expression of calcitonin receptor like receptor (CRLR) in acute myeloid leukemia (AML) with high EVI1 expression, we here characterized the ..
  17. Nikitenko L, Blucher N, Fox S, Bicknell R, Smith D, Rees M. Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms. J Cell Sci. 2006;119:910-22 pubmed
    ..Calcitonin-receptor-like receptor (CRLR, now known as CL) can function as either an AM receptor or a CGRP receptor, when cotransfected with receptor-..
  18. Eskesen K, Tajti J, Hortobagyi T, Szok D, Vecsei L, Edvinsson L. Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction. Ideggyogy Sz. 2007;60:459-66 pubmed
    ..Thus the mRNA expression seems to be unaltered in these disorders. ..
  19. Aldecoa A, Gujer R, Fischer J, Born W. Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells. FEBS Lett. 2000;471:156-60 pubmed
    Differential glycosylation of human and rat (r) calcitonin (CT) receptor-like receptors (CRLR) as a result of interactions with accessory receptor activity-modifying proteins (RAMP)1 or -2 was considered to define CT gene-related peptide (..
  20. Oliver K, Wainwright A, Edvinsson L, Pickard J, Hill R. Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J Cereb Blood Flow Metab. 2002;22:620-9 pubmed
    ..functional binding of these neuropeptides is the G-protein-coupled receptor, the calcitonin receptor-like receptor (CRLR), whose cell surface expression and pharmacology is determined by coexpression of a receptor activity-modifying ..
  21. Fitzsimmons T, Zhao X, Wank S. The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function. J Biol Chem. 2003;278:14313-20 pubmed
    ..calcitonin gene-related peptide (CGRP) receptor requires dimerization of calcitonin receptor-like receptor (CRLR) with receptor activity-modifying protein 1 (RAMP 1)...
  22. Fluhmann B, Muff R, Hunziker W, Fischer J, Born W. A human orphan calcitonin receptor-like structure. Biochem Biophys Res Commun. 1995;206:341-7 pubmed
    ..The receptor-like protein whose ligand remains to be discovered belongs to the family of receptors of calcitonin, parathyroid hormone, secretin, vasointestinal peptide and pituitary adenylate cyclase-activating polypeptide. ..
  23. Nikitenko L, Leek R, Henderson S, Pillay N, Turley H, Generali D, et al. The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis. Clin Cancer Res. 2013;19:5740-8 pubmed publisher
    ..Our findings reveal previously unrecognized CLR upregulation in an autocrine loop with adrenomedullin in RCC with potential application for this GPCR as a target for future functional studies and drug development. ..
  24. Teoh J, Park K, Wang Y, Hu Q, Kim S, Wu G, et al. Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis. Cell Signal. 2014;26:2885-95 pubmed publisher
    ..Gαs/cAMP/PKA activation inhibits ETAR-mediated β-arrestin activation of angiogenic/metastatic Calcrl and Icam2 expression...
  25. Dumont C, Muff R, Fluhmann B, Fischer J, Born W. Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats. Brain Res. 2002;955:64-71 pubmed
    ..mRNA encoding the calcitonin receptor-like receptor (CRLR) and the receptor-activity-modifying proteins (RAMP) 1, -2 and -3 were demonstrated in all the primary cells, but ..
  26. Fukai N, Shichiri M, Ozawa N, Matsushita M, Hirata Y. Coexpression of calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3 mediates the antimigratory effect of adrenomedullin. Endocrinology. 2003;144:447-53 pubmed
    ..of the receptor activity-modifying protein (RAMP) are thought to transport the calcitonin receptor-like receptor (CRLR) to the plasma membrane to function as calcitonin gene-related peptide or adrenomedullin receptors, but their role ..
  27. Aguilera C, Gómez Llorente C, Tofe I, Gil Campos M, Cañete R, Gil Ã. Genome-wide expression in visceral adipose tissue from obese prepubertal children. Int J Mol Sci. 2015;16:7723-37 pubmed publisher
    ..matrix regulation (TNMD and NQO1), adipogenesis (CRYAB and AFF1) and inflammation (ANXA1); by contrast, only CALCRL gene expression was confirmed to be downregulated...
  28. Di Liddo R, Bridi D, Gottardi M, De Angeli S, Grandi C, Tasso A, et al. Adrenomedullin in the growth modulation and differentiation of acute myeloid leukemia cells. Int J Oncol. 2016;48:1659-69 pubmed publisher
    ..impaired cellular differentiation of myeloid leukemia cells to mature granulocytes or monocytes by modulating RAMPs/CRLR expression, PI3K/Akt cascade and the ERK/MAPK signaling pathway...
  29. Pauza A, Rysevaite Kyguoliene K, Malinauskas M, Lukosiene J, Alaburda P, Stankevicius E, et al. Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease: CGRP in diverticular disease. Auton Neurosci. 2019;216:63-71 pubmed publisher
    ..Changes in CGRP and calcitonin receptor-like receptor (CRLR) abundance within enteric ganglia were investigated in sigmoid samples from symptomatic and asymptomatic DD ..
  30. Kawashima Takeda N, Ito Y, Nishizawa N, Kawashima R, Tanaka K, Tsujikawa K, et al. RAMP1 suppresses mucosal injury from dextran sodium sulfate-induced colitis in mice. J Gastroenterol Hepatol. 2017;32:809-818 pubmed publisher composed of receptor activity-modifying protein (RAMP) 1 combined with calcitonin receptor-like receptor (CRLR) for CGRP. The study investigated the role of CGRP in mice with experimentally induced colitis...
  31. Lv Y, Zhang S, Liang X, Zhang H, Xu Z, Liu B, et al. Adrenomedullin 2 Enhances Beiging in White Adipose Tissue Directly in an Adipocyte-autonomous Manner and Indirectly through Activation of M2 Macrophages. J Biol Chem. 2016;291:23390-23402 pubmed
    ..uncoupling respiration, which was mainly mediated by activation of the calcitonin receptor-like receptor (CRLR)·receptor activity-modifying protein 1 (RAMP1) complex and PKA and p38 MAPK signaling pathways...
  32. Kach J, Sandbo N, Sethakorn N, Williams J, Reed E, La J, et al. Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. Am J Physiol Lung Cell Mol Physiol. 2013;304:L757-64 pubmed publisher
    ..ADM) is a vasodilator peptide that activates cAMP/PKA signaling through the calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying proteins (RAMP)...
  33. Liu H, Xiong Y, Wang H, Yang L, Wang C, Liu X, et al. Effects of water extract from epimedium on neuropeptide signaling in an ovariectomized osteoporosis rat model. J Ethnopharmacol. 2018;221:126-136 pubmed publisher
    ..NPY 1 (NPYR1) and 2; calcitonin gene-related peptide and its receptor precursor calcitonin receptor-like receptor (CRLR); vasoactive intestinal peptide (VIP) and its receptor VIP 1 (VIP1R) and 2; and substance P (SP) and its receptor ..
  34. Ratliff W, Saykally J, Kane M, Citron B. Neuromuscular Junction Morphology and Gene Dysregulation in the Wobbler Model of Spinal Neurodegeneration. J Mol Neurosci. 2018;66:114-120 pubmed publisher
    ..We also found increases in gene expression of two acetylcholine receptors within the wobbler biceps, which may be a result of altered CGRP/CALCRL (calcitonin receptor-like receptor) expression.
  35. Kuwasako K, Kitamura K, Nagata S, Hikosaka T, Kato J. Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. Biochem Biophys Res Commun. 2010;392:380-5 pubmed publisher
    Receptor activity-modifying protein 2 (RAMP2) enables calcitonin receptor-like receptor (CRLR) to form an adrenomedullin (AM)-specific receptor...
  36. Wu X, Hao C, Ling M, Guo C, Ma W. Hypoxia-induced apoptosis is blocked by adrenomedullin via upregulation of Bcl-2 in human osteosarcoma cells. Oncol Rep. 2015;34:787-94 pubmed publisher
    ..that ADM acted as a survival factor to inhibit hypoxic-induced apoptosis via interacting with its receptors CRLR-RAMP (2,3) in osteosarcoma cells...
  37. Mackie D, Al Mutairi F, Davis R, Kechele D, Nielsen N, Snyder J, et al. hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. J Exp Med. 2018;215:2339-2353 pubmed publisher
    ..a recessive, in-frame deletion of V205 in the G protein-coupled receptor, Calcitonin Receptor-Like Receptor (hCALCRL)...
  38. Kamitani S, Asakawa M, Shimekake Y, Kuwasako K, Nakahara K, Sakata T. The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. FEBS Lett. 1999;448:111-4 pubmed
    ..Thus, the receptor activity-modifying protein 2/calcitonin receptor-like receptor complex apparently serves as a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells. ..
  39. Nannini M, Astolfi A, Urbini M, Indio V, Santini D, Heinrich M, et al. Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST). BMC Cancer. 2014;14:685 pubmed publisher
    ..In particular, the quadrupleWT GIST tumors are characterized by the overexpression of molecular markers (CALCRL and COL22A1) and of specific oncogenes including tyrosine and cyclin- dependent kinases (NTRK2 and CDK6) and one ..
  40. Leite L, Gonzaga N, Tirapelli D, Tirapelli L, Tirapelli C. Pharmacological characterization of the relaxant effect induced by adrenomedullin in rat cavernosal smooth muscle. Braz J Med Biol Res. 2014;47:876-85 pubmed
    ..Protein and mRNA levels of pre-pro-AM, calcitonin receptor-like receptor (CRLR), and Subtypes 1, 2 and 3 of the receptor activity-modifying protein (RAMP) family were assessed by Western ..
  41. Adriaenssens A, Lam B, Billing L, Skeffington K, Sewing S, Reimann F, et al. A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium. Endocrinology. 2015;156:3924-36 pubmed publisher
    ..Pyy, Gipr, Chrm4, Calcrl, Taar1, and Casr were identified as genes that are highly enriched in D-cells compared with SST-negative cells...
  42. Dong Y, Betancourt A, Chauhan M, Balakrishnan M, Lugo F, Anderson M, et al. Pregnancy Increases Relaxation in Human Omental Arteries to the CGRP Family of Peptides. Biol Reprod. 2015;93:134 pubmed publisher
    ..n = 15) at cesarean delivery, this study shows that the receptor components--calcitonin receptor-like receptor (CALCRL) and receptor activity-modifying proteins (RAMPs) 1, 2 and 3--are localized to endothelial and smooth muscle cells ..
  43. González Hernández A, Marichal Cancino B, Lozano Cuenca J, López Canales J, Muñoz Islas E, Ramírez Rosas M, et al. Heteroreceptors Modulating CGRP Release at Neurovascular Junction: Potential Therapeutic Implications on Some Vascular-Related Diseases. Biomed Res Int. 2016;2016:2056786 pubmed publisher
    ..G-protein coupled receptor (GPCR) composed of three functional proteins: (i) the calcitonin receptor-like receptor (CRLR; a seven-transmembrane protein), (ii) the activity-modifying protein type 1 (RAMP1), and (iii) a receptor component ..
  44. De Martin S, Paliuri G, Belloni A, Orso G, Zanarella E, Stellin G, et al. Expression and distribution of the adrenomedullin system in newborn human thymus. PLoS ONE. 2014;9:e97592 pubmed publisher
  45. Xu M, Qi F, Zhang S, Ma X, Wang S, Wang C, et al. Adrenomedullin promotes the growth of pancreatic ductal adenocarcinoma through recruitment of myelomonocytic cells. Oncotarget. 2016;7:55043-55056 pubmed publisher
    ..adrenomedullin (ADM), and CD11b+ myelomonocytic cells expressed all components of ADM receptors, including GPR182, CRLR, RAMP2 and RAMP3...
  46. Mo C, Huang L, Cui L, Lv C, Lin D, Song L, et al. Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens. J Mol Endocrinol. 2017;59:61-79 pubmed publisher
    ..Here, we characterized cNMB, cGRP and their receptors (cNMBR, cGRPR and cBRS3) in chickens...
  47. Yoshimoto Y, Nishie T, Ito S, Kobayashi Y, Yamamoto Y, Okuda K, et al. Adrenomedullin regulates the speed of oviductal fluid flow in cattle. Mol Reprod Dev. 2017;84:712-718 pubmed publisher
    ..ADM)-a peptide hormone that acts via its receptors, which are complexes of Calcitonin receptor-like receptor (CRLR) and Receptor activity-modifying protein (RAMP) 2 or 3 - promotes oviductal fluid flow in the ampulla of bovine ..
  48. Albertin G, Sorato E, Oselladore B, Mascarin A, Tortorella C, Guidolin D. Involvement of vascular endothelial growth factor signaling in CLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells. Int J Mol Med. 2010;26:289-94 pubmed
  49. Chang C, Park J, Hsu S. Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. J Biol Chem. 2010;285:1075-80 pubmed publisher
  50. Awadalla M, Burdon K, Thapa S, Hewitt A, Craig J. A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma. Mol Vis. 2012;18:2247-54 pubmed
    ..candidate genes were selected; methyl-tetrahydrofolate reductase (MTHFR), calcitonin receptor-like receptor gene (CALCRL), and membrane frizzled-related protein (MFRP)...
  51. Woolley M, Watkins H, Taddese B, Karakullukcu Z, Barwell J, Smith K, et al. The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach. J R Soc Interface. 2013;10:20130589 pubmed publisher
    ..The implications of the most likely structures for receptor activation are discussed. ..
  52. Figueira L, Israel A. Effect of Valsartan on Cerebellar Adrenomedullin System Dysregulation During Hypertension. Cerebellum. 2017;16:132-141 pubmed publisher
    Adrenomedullin (AM) and its receptors components, calcitonin-receptor-like receptor (CRLR), and receptor activity-modifying protein (RAMP1, RAMP2, and RAMP3) are expressed in cerebellum...
  53. Skofitsch G, Jacobowitz D. Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system. Peptides. 1985;6:975-86 pubmed
    ..The discrete distribution of CGRP-like binding sites in a variety of sensory systems of the brain and spinal cord as well as in thalamic and hypothalamic areas suggests a widespread involvement of CGRP in a variety of brain functions. ..
  54. Cottrell G, Alemi F, Kirkland J, Grady E, Corvera C, Bhargava A. Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract. Peptides. 2012;35:202-11 pubmed publisher
    ..Thus, CGRP and IMD appear to be released locally, where they can mediate their effect on their receptors regulating diverse functions such as inflammation, pain and motility. ..
  55. Figueira L, Israel A. Role of cerebellar adrenomedullin in blood pressure regulation. Neuropeptides. 2015;54:59-66 pubmed publisher
    Adrenomedullin (AM) and their receptor components, calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP1, RMP2 and RAMP3) are widely expressed in the central nervous system, including cerebellum...
  56. Wang Y, Li Y, Wang M. Involvement of CGRP receptors in retinal spreading depression. Pharmacol Rep. 2016;68:935-8 pubmed publisher
    ..Western blot was used for detection of calcitonin-receptor like receptor (CALCRL) and intrinsic optical imaging was used for pharmacological investigation...
  57. Fang J, Luan J, Zhu G, Qi C, Yang Z, Zhao S, et al. Intermedin 1-53 Inhibits Myocardial Fibrosis in Rats by Down-Regulating Transforming Growth Factor-?. Med Sci Monit. 2017;23:121-128 pubmed
    ..assay was used to detect the mRNA expression of collagen type I and III, IMD1-53 calcitonin receptor-like receptor (CRLR), transforming growth factor-? (TGF-?), and matrix metalloproteinase-2 (MMP-2)...
  58. Nakayama T, Nakazato T, Naruse H, Fu Z, Wang Z, Soma M, et al. Haplotype-based, case-control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension. J Hum Hypertens. 2017;31:361-365 pubmed publisher
    The adrenomedullin receptor is a complex molecule that comprises the calcitonin-receptor-like receptor (CRLR) and the receptor-activity-modifying protein (RAMP)...
  59. Huang M, Nguyen V, Wu Y, Rastogi S, Lui C, Birnbaum Y, et al. Reducing ischaemia/reperfusion injury through delta-opioid-regulated intrinsic cardiac adrenergic cells: adrenopeptidergic co-signalling. Cardiovasc Res. 2009;84:452-60 pubmed publisher
  60. Meng Q, Shi D, Feng J, Su Y, Long Y, He S, et al. Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress. Ann Clin Lab Sci. 2016;46:5-17 pubmed
    ..expression of IMD along with its receptor components was determined, and the corresponding protein level of the CRLR/RAMPs was also assessed...
  61. Nikitenko L, Brown N, Smith D, MacKenzie I, Bicknell R, Rees M. Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the human uterus. Mol Hum Reprod. 2001;7:655-64 pubmed
    The calcitonin receptor-like receptor (CRLR) can function as a receptor for either calcitonin gene-related peptide (CGRP) or adrenomedullin (AM), depending upon co-expression with members of a novel family of receptor activity-modifying ..
  62. Steiner S, Muff R, Gujer R, Fischer J, Born W. The transmembrane domain of receptor-activity-modifying protein 1 is essential for the functional expression of a calcitonin gene-related peptide receptor. Biochemistry. 2002;41:11398-404 pubmed
    ..CT) gene-related peptide (CGRP), adrenomedullin (AM) and amylin, and a CT receptor or a CT receptor-like receptor (CRLR). Both form heterodimeric RAMP/receptor complexes at the cell surface...
  63. Yallampalli C, Kondapaka S, Lanlua P, Wimalawansa S, Gangula P. Female sex steroid hormones and pregnancy regulate receptors for calcitonin gene-related peptide in rat mesenteric arteries, but not in aorta. Biol Reprod. 2004;70:1055-62 pubmed
    ..The CGRP-A receptor consists of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1); however, the CGRP-B receptor needs to be further characterized...
  64. Qiao X, Wang L, Wang Y, Zhao N, Zhang R, Han W, et al. Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction. Nephrology (Carlton). 2015;20:820-31 pubmed publisher
    ..The expression of IMD and its receptors, calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP1/2/3), in the obstructed kidney was detected by real-time ..
  65. Chauhan M, Yallampalli U, Banadakappa M, Yallampalli C. Involvement of Receptor Activity-Modifying Protein 3 (RAMP3) in the Vascular Actions of Adrenomedullin in Rat Mesenteric Artery Smooth Muscle Cells. Biol Reprod. 2015;93:116 pubmed publisher
    ..ADM, and ADM2 are potent vasodilators that share a seven-transmembrane GPCR, calcitonin receptor-like receptor (CALCRL), whose ligand specificity is dictated by the presence of one of the three receptor activity-modifying proteins (..
  66. Zhang S, Lv Y, Zhang H, Gao S, Wang T, Feng J, et al. Adrenomedullin 2 Improves Early Obesity-Induced Adipose Insulin Resistance by Inhibiting the Class II MHC in Adipocytes. Diabetes. 2016;65:2342-55 pubmed publisher
    ..ADM2 dose-dependently inhibited CIITA-induced MHCII expression by increasing Blimp1 expression in a CRLR/RAMP1-cAMP-dependent manner in cultured adipocytes...
  67. Zhao Q, Wang W, Wang R, Cheng Y. TRPV1 and neuropeptide receptor immunoreactivity and expression in the rat lung and brainstem after lung ischemia-reperfusion injury. J Surg Res. 2016;203:183-92 pubmed publisher
    ..the underlying changes in TRPV1 and neuropeptide receptor expressions, including calcitonin receptor-like receptor (CRLR) and neurokinin 1 receptor (NK1R), after lung ischemia-reperfusion injury (LIRI) remain uncharacterized...
  68. Wang L, Xiao F, Kong L, Wang D, Li H, Wei Y, et al. Intermedin Enlarges the Vascular Lumen by Inducing the Quiescent Endothelial Cell Proliferation. Arterioscler Thromb Vasc Biol. 2018;38:398-413 pubmed publisher
    ..assay, and fluorescent microscopy, we found that intermedin induced the formation of a signaling complex containing CRLR (calcitonin receptor-like receptor)/β-arr1 (β-arrestin1)/Src in ECs and promoted it internalizing into cytoplasm ..
  69. Foord S, Craig R. Isolation and characterisation of a human calcitonin-gene-related-peptide receptor. Eur J Biochem. 1987;170:373-9 pubmed
  70. Chauhan M, Balakrishnan M, Vidaeff A, Yallampalli U, Lugo F, Fox K, et al. Adrenomedullin2 (ADM2)/Intermedin (IMD): A Potential Role in the Pathophysiology of Preeclampsia. J Clin Endocrinol Metab. 2016;101:4478-4488 pubmed
    ..05); ADM2 interacts with a seven-transmembrane G protein-coupled receptor, calcitonin receptor-like receptor (CRLR) in HTR-8/SVneo cells; placental expression of ADM2/CRLR complex is lower in PreE; mRNA for CRLR and receptor ..
  71. Pantaleo M, Urbini M, Indio V, Ravegnini G, Nannini M, De Luca M, et al. Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST. Mol Cancer Res. 2017;15:553-562 pubmed publisher
    ..Overexpression of specific molecular markers (COL22A1 and CALCRL) and genes involved in neural and neuroendocrine lineage (ASCL1, Family B GPCRs) were detected and further ..
  72. Qing X, Svaren J, Keith I. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Am J Physiol Lung Cell Mol Physiol. 2001;280:L547-54 pubmed
    ..The vasodilatory action of CGRP is mediated primarily by CGRP1 receptors. The calcitonin receptor-like receptor (CRLR) and the orphan receptor RDC-1 have been proposed as CGRP1 receptors, and recent evidence suggests that CRLR can ..
  73. Heroux M, Breton B, Hogue M, Bouvier M. Assembly and signaling of CRLR and RAMP1 complexes assessed by BRET. Biochemistry. 2007;46:7022-33 pubmed
    Biochemical and functional evidence suggest that the calcitonin receptor-like receptor (CRLR) interacts with receptor activity-modifying protein-1 (RAMP1) to generate a calcitonin gene-related peptide (CGRP) receptor...
  74. Watkins H, Chakravarthy M, Abhayawardana R, Gingell J, Garelja M, Pardamwar M, et al. Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. J Biol Chem. 2016;291:11657-75 pubmed publisher
    ..These subtype-specific differences have implications for the design of therapeutics aimed at specific AM receptors and for understanding the mechanisms by which accessory proteins affect G protein-coupled receptor function. ..
  75. Kadmiel M, Matson B, Espenschied S, Lenhart P, Caron K. Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. PLoS ONE. 2017;12:e0181597 pubmed publisher
    ..Ramp2 has been primarily characterized in association with calcitonin receptor-like receptor (Calcrl, CLR), forming the canonical receptor complex for the endocrine peptide adrenomedullin (Adm, AM)...
  76. Kuwasako K, Cao Y, Nagoshi Y, Tsuruda T, Kitamura K, Eto T. Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins. Mol Pharmacol. 2004;65:207-13 pubmed
    ..activity-modifying proteins (RAMPs) with calcitonin receptor 2 (CTR2) or calcitonin receptor-like receptor (CRLR) leads to the formation of four functional heterodimeric receptors for human calcitonin gene-related peptide (hCGRP)..
  77. Ramos C, Sun X, Johnson E, Nelson H, Gonzalez Bosc L. Adrenomedullin expression in the developing human fetal lung. J Investig Med. 2014;62:49-55 pubmed publisher
    ..the messenger RNA and protein expression of AM and its receptor components, calcitonin-receptorlike receptor (CRLR), receptor activity-modifying protein (RAMP)2, and RAMP3 in human fetal lung from 10 to 24 weeks of gestation...
  78. Sams A, Jansen Olesen I. Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries. Neurosci Lett. 1998;258:41-4 pubmed
    Recently a new type of proteins modulating the pharmacological profile of the calcitonin receptor-like receptor (CRLR) were identified...
  79. Kamitani S, Sakata T. Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling. Biochim Biophys Acta. 2001;1539:131-9 pubmed
    Calcitonin receptor-like receptor (CRLR) constitutes either a CGRP receptor when complexed with receptor activity-modifying protein 1 (RAMP1) or an adrenomedullin receptor when complexed with RAMP2 or RAMP3...
  80. Hagner S, Haberberger R, Overkamp D, Hoffmann R, Voigt K, McGregor G. Expression and distribution of calcitonin receptor-like receptor in human hairy skin. Peptides. 2002;23:109-16 pubmed
    ..This study aimed to identify the cellular location of calcitonin receptor-like receptor (CRLR) which is pharmacologically identical to CGRP receptor-1, a putative molecular target of CGRP and adrenomedullin...
  81. Sano M, Kuroi N, Nakayama T, Sato N, Izumi Y, Soma M, et al. Association study of calcitonin-receptor-like receptor gene in essential hypertension. Am J Hypertens. 2005;18:403-8 pubmed
    ..The ADM receptor is a complex molecule that consists of calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein 2 (RAMP2)...
  82. Uzan B, Ea H, Launay J, Garel J, Champy R, Cressent M, et al. A critical role for adrenomedullin-calcitonin receptor-like receptor in regulating rheumatoid fibroblast-like synoviocyte apoptosis. J Immunol. 2006;176:5548-58 pubmed
    ..Constituents of the ADM heterodimeric receptor calcitonin receptor-like receptor (CRLR)/receptor activity-modifying protein (RAMP)-2 were up-regulated at the mRNA and protein levels in cultured RA-FLS ..
  83. Davis R, Kechele D, Blakeney E, Pawlak J, Caron K. Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation. JCI Insight. 2017;2:e92465 pubmed publisher
    ..deletion of the key lymphangiogenic receptor for the adrenomedullin peptide, calcitonin receptor-like receptor (Calcrl), and found that the loss of lymphatic Calcrl was sufficient to induce intestinal lymphangiectasia, ..
  84. Harzenetter M, Keller U, Beer S, Riedl C, Peschel C, Holzmann B. Regulation and function of the CGRP receptor complex in human granulopoiesis. Exp Hematol. 2002;30:306-12 pubmed
    ..CGRP receptor subunits receptor activity-modifying protein-1 (RAMP-1) and calcitonin receptor-like receptor (CRLR) as well as for the intracellular adapter protein CGRP-receptor component protein (CGRP-RCP) were found in CD34(+) ..
  85. Bomberger J, Parameswaran N, Hall C, Aiyar N, Spielman W. Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. J Biol Chem. 2005;280:9297-307 pubmed
    ..receptors are comprised of RAMP2 or RAMP3 (AM1R and AM2R, respectively) and calcitonin receptor-like receptor (CRLR), while a CRLR heterodimer with RAMP1 yields a calcitonin gene-related peptide receptor...
  86. Michou L, Garnier S, Barbet S, Glikmans E, Ea H, Uzan B, et al. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. Clin Exp Rheumatol. 2008;26:1083-6 pubmed
    ..Adrenomedullin binds to a heterodimeric functional receptor, of calcitonin receptor-like receptor (CRLR) coupled with a receptor activity-modifying protein-2 (RAMP-2), which is also overexpressed by rheumatoid ..
  87. Kuwasako K, Kitamura K, Nagata S, Kato J. Flow cytometric analysis of the calcitonin receptor-like receptor domains responsible for cell-surface translocation of receptor activity-modifying proteins. Biochem Biophys Res Commun. 2009;384:249-54 pubmed publisher
    ..associate with a wide variety of G protein-coupled receptors (GPCRs), including calcitonin receptor-like receptor (CRLR)...
  88. Booe J, Walker C, Barwell J, Kuteyi G, Simms J, Jamaluddin M, et al. Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Mol Cell. 2015;58:1040-52 pubmed publisher
    ..The structures and accompanying pharmacology data reveal how a class of accessory membrane proteins modulate ligand binding of a GPCR and may inform drug development targeting CLR:RAMP complexes. ..
  89. Frayon S, Cueille C, Gnidehou S, De Vernejoul M, Garel J. Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells. Biochem Biophys Res Commun. 2000;270:1063-7 pubmed
    A recent report has shown that in vitro the RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells...
  90. Kuwasako K, Kitamura K, Uemura T, Nagoshi Y, Kato J, Eto T. The function of extracellular cysteines in the human adrenomedullin receptor. Hypertens Res. 2003;26 Suppl:S25-31 pubmed
    When co-expressed with receptor activity-modifying protein (RAMP) 2, calcitonin receptor-like receptor (CRLR) functions as an adrenomedullin (AM) receptor (CRLR/RAMP2)...
  91. Nagoshi Y, Kuwasako K, Cao Y, Imamura T, Kitamura K, Eto T. Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells. Peptides. 2004;25:1115-21 pubmed
    ..showed that these cells abundantly express two AM receptors comprised of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) or RAMP2...
  92. Padilla B, Cottrell G, Roosterman D, Pikios S, Muller L, Steinhoff M, et al. Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. J Cell Biol. 2007;179:981-97 pubmed
    ..We propose a mechanism by which endosomal ECE-1 degrades neuropeptides in endosomes to disrupt the peptide/receptor/beta-arrestin complex, freeing internalized receptors from beta-arrestins and promoting recycling and resensitization. ..