calcitonin

Summary

Gene Symbol: calcitonin
Description: calcitonin related polypeptide alpha
Alias: CALC1, CGRP, CGRP-I, CGRP1, PCT, calcitonin, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin 1, calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha, katacalcin
Species: human
Products:     calcitonin

Top Publications

  1. Buervenich S, Xiang F, Sydow O, Jönsson E, Sedvall G, Anvret M, et al. Identification of four novel polymorphisms in the calcitonin/alpha-CGRP (CALCA) gene and an investigation of their possible associations with Parkinson disease, schizophrenia, and manic depression. Hum Mutat. 2001;17:435-6 pubmed
    We identified novel polymorphisms in the calcitonin/CGRPalpha (CALCA) gene by direct sequencing of genomic DNA and subsequent genotyping by RFLP (restriction fragment length polymorphism) detection and investigated association with ..
  2. Yan L, Yinghui T, Bo Y, Gang Z, Xian X, Lu Z. Effect of calcitonin gene-related peptide on nitric oxide production in osteoblasts: an experimental study. Cell Biol Int. 2011;35:757-65 pubmed publisher
    The aim of this study was to investigate the in vitro effects and regulatory mechanism of CGRP (calcitonin gene-related peptide) on NO (nitric oxide) production in osteoblasts...
  3. Breeze A, Harvey T, Bazzo R, Campbell I. Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics. Biochemistry. 1991;30:575-82 pubmed
    The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by 1H NMR in a mixed-solvent system of 50% trifluoroethanol/50% H2O at pH 3.7 and 27 degrees C...
  4. Gangula P, Zhao H, Supowit S, Wimalawansa S, Dipette D, Westlund K, et al. Increased blood pressure in alpha-calcitonin gene-related peptide/calcitonin gene knockout mice. Hypertension. 2000;35:470-5 pubmed
    Nerves that contain calcitonin gene-related peptide (CGRP) are components of the sensory nervous system...
  5. Goodman M, Ferrell R, McDuffie K, Thompson P, Wilkens L, Bushley A, et al. Calcitonin gene polymorphism CALCA-624 (T/C) and ovarian cancer. Environ Mol Mutagen. 2005;46:53-8 pubmed
    ..2002. Am J Epidemiol 156:148-57). The CALCA gene codes for calcitonin, an important regulator of bone calcium metabolism...
  6. Gurda Duda A, Kusnierz Cabala B, Nowak W, Naskalski J, Kulig J. Assessment of the prognostic value of certain acute-phase proteins and procalcitonin in the prognosis of acute pancreatitis. Pancreas. 2008;37:449-53 pubmed publisher
    ..The best efficiency in the early prediction of severe AP would be achieved with the measurement of procalcitonin, total calcium level, and lactic acid dehydrogenase activity immediately after admission to the ward. ..
  7. Stolz D, Smyrnios N, Eggimann P, Pargger H, Thakkar N, Siegemund M, et al. Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study. Eur Respir J. 2009;34:1364-75 pubmed publisher
    ..Serum procalcitonin reduces antibiotic therapy exposure in patients with ventilator associated pneumonia. ..
  8. Wang X, Guo X, Qu S, Weng J, Cheng C. Temporal and spatial CGRP innervation in recombinant human bone morphogenetic protein induced spinal fusion in rabbits. Spine (Phila Pa 1976). 2009;34:2363-8 pubmed publisher
    ..To explore the temporal and spatial distribution of sensory nerve fibers expressing calcitonin-gene related peptide (CGRP) during spinal fusion induced by recombinant human bone morphogenetic protein-4 and ..
  9. Suárez Santamaría M, Santolaria F, Pérez Ramírez A, Alemán Valls M, Martínez Riera A, Gonzalez Reimers E, et al. Prognostic value of inflammatory markers (notably cytokines and procalcitonin), nutritional assessment, and organ function in patients with sepsis. Eur Cytokine Netw. 2010;21:19-26 pubmed publisher
    ..However, it proved useful to discriminate between non-complicated and severe forms of sepsis. ..

More Information

Publications101 found, 100 shown here

  1. Struck J, de Almeida P, Bergmann A, Morgenthaler N. High concentrations of procalcitonin but not mature calcitonin in normal human milk. Horm Metab Res. 2002;34:460-5 pubmed
    Procalcitonin (PCT) is one of the precursors in the synthesis of calcitonin in thyroidal C-cells and other neuroendocrine cells...
  2. Dong M, Pinon D, Cox R, Miller L. Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor. J Biol Chem. 2004;279:31177-82 pubmed
    The calcitonin receptor is a member of the class B family of G protein-coupled receptors, which contains numerous potentially important drug targets...
  3. Morita A, Nakayama T, Soma M, Mizutani T. Association between the calcitonin-related peptide alpha (CALCA) gene and essential hypertension in Japanese subjects. Am J Hypertens. 2007;20:527-32 pubmed
    b>Calcitonin-related peptide alpha (CALCA) is a neuropeptide that is a very potent vasodilator. It has been reported that CALCA knockout mice have a significantly elevated systolic blood pressure (BP)...
  4. Schneider H, Lam Q. Procalcitonin for the clinical laboratory: a review. Pathology. 2007;39:383-90 pubmed
    ..It has obtained FDA approval and is now widely marketed in the United States and Europe. This review summarises the current assays available, the evidence for its use and possible future applications of the assay. ..
  5. Karlsson S, Heikkinen M, Pettila V, Alila S, Väisänen S, Pulkki K, et al. Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study. Crit Care. 2010;14:R205 pubmed publisher
    This prospective study investigated the predictive value of procalcitonin (PCT) for survival in 242 adult patients with severe sepsis and septic shock treated in intensive care...
  6. Ding W, Stohl L, Wagner J, Granstein R. Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunity. J Immunol. 2008;181:6020-6 pubmed
    ..LC are associated with nerves containing the neuropeptide calcitonin gene-related peptide (CGRP), and CGRP inhibits LC Ag-presentation in several models including presentation to a ..
  7. Wedemeyer C, Kauther M, Hanenkamp S, Nuckel H, Bau M, Siffert W, et al. BCL2-938C>A and CALCA-1786T>C polymorphisms in aseptic loosened total hip arthroplasty. Eur J Med Res. 2009;14:250-5 pubmed
    ..The CALCA -1786T>C polymorphism belongs to the CALCA gene encoding alpha-Calcitonin Gene Related Peptide (CGRP) and Calcitonin...
  8. Hur M, Moon H, Yun Y, Kim K, Kim H, Lee K. [Comparison of diagnostic utility between procalcitonin and C-reactive protein for the patients with blood culture-positive sepsis]. Korean J Lab Med. 2009;29:529-35 pubmed publisher
    Procalcitonin (PCT) is a relatively new marker for bacterial infections, and its diagnostic utility has been variable across the studies...
  9. Schuetz P, Suter Widmer I, Chaudri A, Christ Crain M, Zimmerli W, Mueller B. Prognostic value of procalcitonin in community-acquired pneumonia. Eur Respir J. 2011;37:384-92 pubmed publisher
    The prognostic value of procalcitonin (PCT) levels to predict mortality and other adverse events in community-acquired pneumonia (CAP) remains undefined...
  10. Akopian A, Demulder A, Ouriaghli F, Corazza F, Fondu P, Bergmann P. Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?. Peptides. 2000;21:559-64 pubmed
    ..Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like ..
  11. Howitt S, Kilk K, Wang Y, Smith D, Langel U, Poyner D. The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions. Br J Pharmacol. 2003;138:325-32 pubmed
    1. The role of individual residues in the 8-18 helix of CGRP(8-37) in promoting high-affinity binding to CGRP(1) receptors expressed on rat L6 and human SK-N-MC cells has been examined...
  12. Villa I, Mrak E, Rubinacci A, Ravasi F, Guidobono F. CGRP inhibits osteoprotegerin production in human osteoblast-like cells via cAMP/PKA-dependent pathway. Am J Physiol Cell Physiol. 2006;291:C529-37 pubmed
    ..Primary cultures of human osteoblast-like cells (hOB) express calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1, and, because CGRP stimulates cAMP (one ..
  13. Mofidi R, Suttie S, Patil P, Ogston S, Parks R. The value of procalcitonin at predicting the severity of acute pancreatitis and development of infected pancreatic necrosis: systematic review. Surgery. 2009;146:72-81 pubmed publisher
    Many studies have evaluated serum levels of procalcitonin (PCT) as a predictor in the development of severe acute pancreatitis (SAP) and infected pancreatic necrosis (IPN)...
  14. Barwell J, Conner A, Poyner D. Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. Biochim Biophys Acta. 2011;1813:1906-16 pubmed publisher
    ..an alanine/leucine scan of ECLs 1 and 3 and loop-associated transmembrane (TM) domains of the secretin-like GPCR calcitonin receptor-like receptor which associates with receptor activity modifying protein 1 to form the CGRP receptor...
  15. Woo S, Noh M, Kim B, Hsing C, Han J, Ryu S, et al. Comparison of serum procalcitonin with Ranson, APACHE-II, Glasgow and Balthazar CT severity index scores in predicting severity of acute pancreatitis. Korean J Gastroenterol. 2011;58:31-7 pubmed
    The aim of this study is to assess serum procalcitonin (PCT) for early prediction of severe acute pancreatitis compared with multiple scoring systems and biomarkers...
  16. McLatchie L, Fraser N, Main M, Wise A, Brown J, Thompson N, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998;393:333-9 pubmed
    b>Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles...
  17. Padilla B, Cottrell G, Roosterman D, Pikios S, Muller L, Steinhoff M, et al. Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. J Cell Biol. 2007;179:981-97 pubmed
    ..b>Calcitonin gene-related peptide (CGRP) co-internalizes with calcitonin receptor-like receptor (CLR), receptor activity-..
  18. Montagnana M, Lippi G, Tessitore N, Salvagno G, Danese E, Targher G, et al. Procalcitonin values after dialysis is closely related to type of dialysis membrane. Scand J Clin Lab Invest. 2009;69:703-7 pubmed publisher
    ..In this setting, procalcitonin (PCT) could be useful for detection of systemic bacterial infections...
  19. Leite L, Gonzaga N, Tirapelli D, Tirapelli L, Tirapelli C. Pharmacological characterization of the relaxant effect induced by adrenomedullin in rat cavernosal smooth muscle. Braz J Med Biol Res. 2014;47:876-85 pubmed
    ..Protein and mRNA levels of pre-pro-AM, calcitonin receptor-like receptor (CRLR), and Subtypes 1, 2 and 3 of the receptor activity-modifying protein (RAMP) family ..
  20. Passaglia P, Gonzaga N, Tirapelli D, Tirapelli L, Tirapelli C. Pharmacological characterisation of the mechanisms underlying the relaxant effect of adrenomedullin in the rat carotid artery. J Pharm Pharmacol. 2014;66:1734-46 pubmed publisher
    ..Protein and mRNA expression of AM, calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMP)1, 2, 3 were detected in carotid ..
  21. Filiz A, Tepe N, Eftekhari S, Boran H, Dilekoz E, Edvinsson L, et al. CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior. Cephalalgia. 2017;:333102417735845 pubmed publisher
    Background and objective The present study aimed to investigate the effects of selective calcitonin gene related peptide (CGRP) receptor antagonist (MK-8825) on cortical spreading depression (CSD) induced pain behavior and anxiety in ..
  22. Couvineau A, Laburthe M. The family B1 GPCR: structural aspects and interaction with accessory proteins. Curr Drug Targets. 2012;13:103-15 pubmed
    ..1 and 2 receptors (GLPR), gastric inhibitory peptide receptor (GIPR), parathyroid hormone receptors (PTHR), calcitonin receptors (CTR) and corticotropin-releasing factor receptors (CRFR)...
  23. Zhu Q, Ni X, Lu W, Zhang J, Ren J, Wu D, et al. Intermedin reduces neointima formation by regulating vascular smooth muscle cell phenotype via cAMP/PKA pathway. Atherosclerosis. 2017;266:212-222 pubmed publisher
    ..PDGF-BB reduced IMD mRNA expression in rat primary cultured VSMCs but increased that of its receptors, calcitonin receptor-like receptor or receptor activity-modifying proteins...
  24. Ruiz Esteban R, Sarabia P, Delgado E, Aguado C, Cuervo Arango J, Varela M. Procalcitonin and C-reactive protein levels as diagnostic tools in febrile patients admitted to a General Internal Medicine ward. Clin Biochem. 2012;45:22-5 pubmed publisher
    ..2 ng/mL and 0.03 and 1 for a cut-off point of 10.0 ng/mL. However, in subgroup analysis, Pro-CT was able to discriminate between infectious and inflammatory diseases (Welch two sample t-test t=2.39, df=44.3, p=0.021). ..
  25. Magnussen C, Hung S, Ribeiro Da Silva A. Novel expression pattern of neuropeptide Y immunoreactivity in the peripheral nervous system in a rat model of neuropathic pain. Mol Pain. 2015;11:31 pubmed publisher
    ..Peptidergic and non-peptidergic C fibers expressing calcitonin gene-related peptide (CGRP) or binding isolectin B4 (IB4), respectively, never expressed NPY...
  26. Lee Y, Wu S, Arinzeh T, Bunge M. Enhanced noradrenergic axon regeneration into schwann cell-filled PVDF-TrFE conduits after complete spinal cord transection. Biotechnol Bioeng. 2017;114:444-456 pubmed publisher
    ..Sensory CGRP+ (calcitonin gene-related peptide) axons were present at the caudal interface...
  27. Rahimzadeh N, Otukesh H, Hoseini R, Shadani S, Hooman N. Serum procalcitonin level for prediction of high-grade vesicoureteral reflux in urinary tract infection. Iran J Kidney Dis. 2014;8:105-8 pubmed
    ..31 ng/mL or greater was 90% and the specificity was 32% for diagnosis of high-grade VUR. We concluded that serum procalcitonin concentration is a sensitive and promising predictor of high-grade VUR. ..
  28. Fernandes V, Hernández M. The Role of Nitric Oxide and Hydrogen Sulfide in Urinary Tract Function. Basic Clin Pharmacol Toxicol. 2016;119 Suppl 3:34-41 pubmed publisher
    ..In the bladder base and distal ureter, the co-localization of neuronal NO synthase with substance P and calcitonin gene-related peptide in sensory nerves as well as the existence of a high nicotinamide adenine dinucleotide ..
  29. Jablonski H, Rekasi H, Jager M. The influence of calcitonin gene-related peptide on markers of bone metabolism in MG-63 osteoblast-like cells co-cultured with THP-1 macrophage-like cells under virtually osteolytic conditions. BMC Musculoskelet Disord. 2016;17:199 pubmed publisher
    The neuropeptide calcitonin gene-related peptide (CGRP) has been described to have an inhibitory effect on endotoxin- and wear particle-induced inflammation in the early stages of periprosthetic osteolysis...
  30. Allais G, Chiarle G, Sinigaglia S, Benedetto C. Menstrual Migraine: a review of current and developing pharmacotherapies for women. Expert Opin Pharmacother. 2017;: pubmed publisher
    ..triptans, anti-inflammatory drugs, hormonal strategies) and drugs in development (in particular those acting on calcitonin gene-related peptide) for the treatment of acute migraine attacks and the prophylaxis of menstrual migraine...
  31. Samuelov L, Kinori M, Bertolini M, Paus R. Neural controls of human hair growth: calcitonin gene-related peptide (CGRP) induces catagen. J Dermatol Sci. 2012;67:153-5 pubmed publisher
  32. Papadakis G, Keramidas I, Triantafillou E, Kanouta F, Pappa T, Kaltzidou V, et al. Association of Basal and Calcium-stimulated Calcitonin Levels with Pathological Findings After Total Thyroidectomy. Anticancer Res. 2015;35:4251-8 pubmed
    Medullary thyroid carcinoma (MTC) originates from thyroid C-cells and is a calcitonin-secreting tumor. Calcitonin is also elevated in C-cell hyperplasia (CCH)...
  33. Avetisyan M, Wang H, Schill E, Bery S, Grider J, Hassell J, et al. Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. J Neurosci. 2015;35:11543-58 pubmed publisher
    ..In adult mice, MET was restricted to a subset of calcitonin gene-related peptide-immunoreactive (IR) myenteric plexus neurons thought to be intrinsic primary afferent ..
  34. Toth V, Feher A, Nemeth J, Gyertyán I, Zadori Z, Gyires K. Modulation of central endocannabinoid system results in gastric mucosal protection in the rat. Brain Res Bull. 2018;139:224-234 pubmed publisher
    ..Catalepsy and the body temperature were also evaluated. Mucosal calcitonin gene-related peptide (CGRP), somatostatin concentrations and superoxide dismutase (SOD) activity were measured...
  35. Kaiser E, Russo A. CGRP and migraine: could PACAP play a role too?. Neuropeptides. 2013;47:451-61 pubmed publisher
    ..In the past decade, the role of the neuropeptide calcitonin gene-related peptide (CGRP) in migraine has been firmly established by clinical studies...
  36. Saper C. The House Alarm. Cell Metab. 2016;23:754-5 pubmed publisher
    Campos et al. (2016) identify a role for CGRP neurons in the external lateral parabrachial nucleus in regulating meal size in response to vagal or hormonal stimuli...
  37. Jacobs B, Dussor G. Neurovascular contributions to migraine: Moving beyond vasodilation. Neuroscience. 2016;338:130-144 pubmed publisher
    ..Conversely, neurons release factors such as norepinephrine and calcitonin gene-related peptide (CGRP) that act on cells native to blood vessels...
  38. Tanaka S, Yoshida A, Kono S, Oguma T, Hasegawa K, Ito M. Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures. J Bone Miner Metab. 2016;: pubmed
    ..b>Calcitonin, a bone resorption inhibitor, has been reported to alleviate pain in such patients; however, few clinical ..
  39. Kim S, Jeong T, Lee W, Chun S, Min W. Procalcitonin in the assessment of bacteraemia in emergency department patients: results of a large retrospective study. Ann Clin Biochem. 2015;52:654-9 pubmed publisher
    ..932 (p = 0.018). When procalcitonin is used as a serum marker for ruling out bacteraemia, a cut-off of 0.1 ng/mL may be used. Procalcitonin improves the diagnostic accuracy of existing markers of bacteraemia. ..
  40. Abdelaziz D, Abdullah S, Magnussen C, Ribeiro Da Silva A, Komarova S, Rauch F, et al. Behavioral signs of pain and functional impairment in a mouse model of osteogenesis imperfecta. Bone. 2015;81:400-6 pubmed publisher
    ..and WT mice in innervation of the glabrous skin of the hindpaw or in expression of the pain-related neuropeptide calcitonin gene-related protein in sensory neurons...
  41. Bossowska A, Lepiarczyk E, Mazur U, Janikiewicz P, Markiewicz W. Botulinum toxin type A induces changes in the chemical coding of substance P-immunoreactive dorsal root ganglia sensory neurons supplying the porcine urinary bladder. Toxins (Basel). 2015;7:4797-816 pubmed publisher
    ..and their chemical profile was disclosed with double-labelling immunohistochemistry using antibodies against SP, calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase activating polypeptide (PACAP), neuronal nitric oxide ..
  42. Woolley M, Simms J, Mobarec J, Reynolds C, Poyner D, Conner A. Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach. Mol Cell Endocrinol. 2017;454:39-49 pubmed publisher
    ..ECL2 is fundamental for ligand-induced activation of the calcitonin gene related peptide (CGRP) receptor, a family B GPCR implicated in migraine and heart disease...
  43. Tsatsaris V, Tarrade A, Merviel P, Garel J, Segond N, Jullienne A, et al. Calcitonin gene-related peptide (CGRP) and CGRP receptor expression at the human implantation site. J Clin Endocrinol Metab. 2002;87:4383-90 pubmed
    b>Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide produced by tissue-specific alternative splicing of the primary transcript of the calcitonin gene...
  44. Al Salam S, Hameed R, Parvez H, Adeghate E. Diabetes mellitus decreases the expression of calcitonin-gene related peptide, gamma-amino butyric acid and glutamic acid decarboxylase in human pancreatic islet cells. Neuro Endocrinol Lett. 2009;30:506-10 pubmed
    The pattern of distribution of calcitonin-gene related peptide (CGRP), a neuropeptide, gamma-aminobutyric acid (GABA), a neurotransmitter and GABA-converting enzyme, glutamic acid decarboxylase (GAD) in the pancreas of diabetic patients ..
  45. Itoh Watanabe H, Kamihira Ishijima M, Javkhlantugs N, Inoue R, Itoh Y, Endo H, et al. Role of aromatic residues in amyloid fibril formation of human calcitonin by solid-state 13C NMR and molecular dynamics simulation. Phys Chem Chem Phys. 2013;15:8890-901 pubmed publisher
    b>Calcitonin (CT) is an amyloid fibril forming peptide...
  46. Allen P, Luebke A. Reflex Modification Audiometry Reveals Dual Roles for Olivocochlear Neurotransmission. Front Cell Neurosci. 2017;11:361 pubmed publisher
    ..expressing an overactive receptor [Ld'T mutation in ?9 nAChR KI], or lacking an LOC efferent neuropeptide, alpha calcitonin gene-related peptide [?CGRP (-/-)] only in the CNS...
  47. Fromy B, Josset Lamaugarny A, Aimond G, Pagnon Minot A, Marics I, Tattersall G, et al. Disruption of TRPV3 Impairs Heat-Evoked Vasodilation and Thermoregulation: A Critical Role of CGRP. J Invest Dermatol. 2018;138:688-696 pubmed publisher
    ..that TRPV3 is involved in the local thermoregulatory control of skin blood flow by initiating the release of calcitonin gene-related peptide and nitric oxide in response to local heating of the skin...
  48. Kelly D, Khan S, Dhillon O, Quinn P, Struck J, Squire I, et al. Procalcitonin as a prognostic marker in patients with acute myocardial infarction. Biomarkers. 2010;15:325-31 pubmed publisher
    ..Procalcitonin was related to markers of LV dysfunction and remodelling. Procalcitonin is associated with MACE, LV dysfunction and remodelling post-AMI. ..
  49. Urbonas V, Eidukaite A, Tamulienė I. The predictive value of soluble biomarkers (CD14 subtype, interleukin-2 receptor, human leucocyte antigen-G) and procalcitonin in the detection of bacteremia and sepsis in pediatric oncology patients with chemotherapy-induced febrile neutropenia. Cytokine. 2013;62:34-7 pubmed publisher
    ..to evaluate diagnostic value of soluble biomarkers (CD14 subtype, interleukin-2 receptor, HLA-G) and procalcitonin (PCT) in the identification of infectious process at the beginning of a febrile episode in pediatric oncology patients...
  50. Machens A, Dralle H. Surgical Treatment of Medullary Thyroid Cancer. Recent Results Cancer Res. 2015;204:187-205 pubmed publisher
    ..To improve outcome, routine calcitonin screening in nodular thyroid disease and DNA-based screening of the offspring in RET families are effective ..
  51. Zhao L, Huang L, Zhang X. Systemic lupus erythematosus-related hypercalcemia with ectopic calcinosis. Rheumatol Int. 2016;36:1023-6 pubmed publisher
    ..Glucocorticoid, cyclophosphamide plus calcitonin and etidronate were administered and the patient improved greatly...
  52. Hsu S, Yao C, Hsu Y, Lin J, Chen Y, Chen Y. Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model. Sci Rep. 2017;7:42280 pubmed publisher
    ..animal behaviour, neuronal connectivity, macrophage infiltration, location and expression levels of calcitonin gene-related peptide (CGRP), and expression levels of both nerve growth factors and immunoregulatory factors...
  53. Di Angelantonio S, Giniatullin R, Costa V, Sokolova E, Nistri A. Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells. Br J Pharmacol. 2003;139:1061-73 pubmed
    ..2. Calcitonin gene-related peptide (CGRP) and its N-terminal fragments have been shown to exert complex inhibitory as well ..
  54. Lin Y, Liu H, Day Y, Chang C, Hsu P, Chen J. Activation of NPFFR2 leads to hyperalgesia through the spinal inflammatory mediator CGRP in mice. Exp Neurol. 2017;291:62-73 pubmed publisher
    ..Inflammatory mediators within the spinal cord, calcitonin gene-related peptide (CGRP) and substance P (SP), were up-regulated in NPFFR2-Tg and chronic NPFFR2 agonist-..
  55. Matsumoto Y, Kanamoto K, Kawakubo K, Aomi H, Matsumoto T, Ibayashi S, et al. Gastroprotective and vasodilatory effects of epidermal growth factor: the role of sensory afferent neurons. Am J Physiol Gastrointest Liver Physiol. 2001;280:G897-903 pubmed
    ..hyperemic and gastroprotective effects via capsaicin-sensitive afferent neurons, including the release of calcitonin gene-related peptide (CGRP)...
  56. Zhao Y, Wang Y, Yue Y, Zhao W, Feng G. Variation of plasma levels of endothelin, calcitonin gene-related peptide, nitric oxide, and malondialdehyde in acute myocardial ischemia reperfusion injury in a rabbit model. Genet Mol Res. 2015;14:5577-84 pubmed publisher
    We examined the variation in plasma levels of endothelin (ET), calcitonin gene-related peptide (CGRP), nitric oxide (NO), and malondialdehyde (MDA), as well as superoxide dismutase (SOD) activity, in acute myocardial ischemia reperfusion ..
  57. Jin L, Ding M, Oklopcic A, Aghdasi B, Xiao L, Li Z, et al. Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides. Nanomedicine. 2017;13:2049-2059 pubmed publisher
    ..In addition, fullerol also decreased the expression of substance P and CGRP in the cultured DRGs...
  58. Skofitsch G, Jacobowitz D. Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system. Peptides. 1985;6:975-86 pubmed
    Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system...
  59. Quintana G, Medina Y, Rojas C, Fernandez A, Restrepo J, Rondon F, et al. The use of procalcitonin determinations in evaluation of systemic lupus erythematosus. J Clin Rheumatol. 2008;14:138-42 pubmed publisher
    Procalcitonin (PCT), the precursor of the calcitonin, is synthesized in the parafollicular C-cells of the thyroid...
  60. Bilgir O, Bilgir F, Kebapcilar L, Bozkaya G, Calan M, Kırbıyık H, et al. Comparative levels of macrophage migration inhibitory factor, procalcitonin, osteoprotegerin, interleukin-8, hs-C reactive protein, D-dimer in febrile neutropenia, newly diagnosed cancer patients, and infectious fever. Transfus Apher Sci. 2012;46:19-24 pubmed publisher
    The purpose of this study is to determine the levels of procalcitonin (PCT), IL-8 (interleukin-8), MIF (macrophage migration inhibitory factor), osteoprotegerin (OPG), hs-CRP and D-dimer during fever above 38.3°C due to various causes...
  61. Hou X, Li H, Zhang C, Wang J, Li X, Li X. Overexpression of Fibulin-5 attenuates burn-induced inflammation via TRPV1/CGRP pathway. Exp Cell Res. 2017;357:320-327 pubmed publisher
    ..initiation factor 2, eIF2?), capsaicin (an agonist of transient receptor potential vanilloid (TRPV)-1), and an anti-CGRP neutralizing antibody...
  62. Sorby Adams A, Marcoionni A, Dempsey E, Woenig J, Turner R. The Role of Neurogenic Inflammation in Blood-Brain Barrier Disruption and Development of Cerebral Oedema Following Acute Central Nervous System (CNS) Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..In particular, release of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) appear to be critically involved...
  63. Ashina H, Newman L, Ashina S. Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment. Neurol Sci. 2017;38:2089-2093 pubmed publisher
    b>Calcitonin gene-related peptide (CGRP) is a key signaling molecule involved in migraine pathophysiology...
  64. Matsubara S, Shiraishi A, Sakai T, Okuda T, Satake H. Heterodimerization of the prostaglandin E2 receptor EP2 and the calcitonin receptor CTR. PLoS ONE. 2017;12:e0187711 pubmed publisher
    ..In this paper, we identified a novel GPCR heterodimer between prostaglandin E2 (PGE2) receptor 2 (EP2) and calcitonin (CT) receptor (CTR)...
  65. Marshall I, Al Kazwini S, Holman J, Craig R. Human alpha-calcitonin gene-related peptide (CGRP) is a potent vasodilator in human mesenteric vasculature. Br J Clin Pharmacol. 1988;26:691-5 pubmed
    1. The effect of human alpha-calcitonin gene-related peptide (CGRP) and sodium nitroprusside have been measured on human isolated mesenteric vasculature and on rings of human superior mesenteric artery and saphenous vein. 2...
  66. Dong Y, Vegiraju S, Yallampalli C. Ca2+ signaling in human fetoplacental vasculature: effect of CGRP on umbilical vein smooth muscle cytosolic Ca2+ concentration. Am J Physiol Heart Circ Physiol. 2005;289:H960-7 pubmed
    ..These cells express mRNA for CGRP receptor components, calcitonin receptor-like receptor, and receptor activity-modifying protein-1...
  67. Matsuda M, Yamamoto T, Hirata M. Ca2+-dependent regulation of calcitonin gene expression by the transcriptional repressor DREAM. Endocrinology. 2006;147:4608-17 pubmed
    b>Calcitonin (CT), whose secretion from thyroid glands is regulated by increases in the concentration of extracellular Ca(2+), is a well-known hormone that regulates calcium homeostasis...
  68. Piechota M, Banach M, Irzmanski R, Misztal M, Rysz J, Barylski M, et al. N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients. Cell Mol Biol Lett. 2007;12:162-75 pubmed
    ..this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients...
  69. Greco R, Tassorelli C, Sandrini G, Di Bella P, Buscone S, Nappi G. Role of calcitonin gene-related peptide and substance P in different models of pain. Cephalalgia. 2008;28:114-26 pubmed publisher
    b>Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia...
  70. Park E, Jeon S, Weon H, Cho H, Youn D. Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn. Neurosci Lett. 2017;656:9-14 pubmed publisher
    ..part of inner lamina II and distinctly co-localized with molecular markers of C-fibers, such as peptidergic calcitonin gene-related protein and transient receptor potential vanilloid type 1 and non-peptidergic isolectin B4...
  71. Shimizu N, Doyal M, Goins W, Kadekawa K, Wada N, Kanai A, et al. Morphological changes in different populations of bladder afferent neurons detected by herpes simplex virus (HSV) vectors with cell-type-specific promoters in mice with spinal cord injury. Neuroscience. 2017;364:190-201 pubmed publisher
    ..SCI mice were injected into the bladder wall with HSV mCherry vectors driven by the cytomegalovirus (CMV) promoter, CGRP promoter, TRPV1 promoter or neurofilament 200 (NF200) promoter...
  72. Fehrenbacher J, Guo C, Kelley M, Vasko M. DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1. Neuroscience. 2017;366:23-35 pubmed publisher
    ..DNA damage was assessed by pH2A.X expression and the release of the neuropeptide, calcitonin gene-related peptide (CGRP), was measured as an index of neuronal sensitivity...
  73. Yamamoto Y, Nakamuta N. Morphology of P2X3-immunoreactive nerve endings in the rat tracheal mucosa. J Comp Neurol. 2017;: pubmed publisher
    ..Flat axon terminals sometimes partly ensheathed neuroendocrine cells with immunoreactivity for SNAP25 or CGRP. Some axons and axon terminals with P2X3 immunoreactivity were immunoreactive for P2X2, while some terminals were ..
  74. Allelein S, Ehlers M, Morneau C, Schwartz K, Goretzki P, Seppel T, et al. Measurement of Basal Serum Calcitonin for the Diagnosis of Medullary Thyroid Cancer. Horm Metab Res. 2017;: pubmed publisher
    b>Calcitonin (CT), a tumor marker for medullary thyroid cancer (MTC), can be stimulated with pentagastrin or calcium...
  75. Mollet A, Lutz T, Meier S, Riediger T, Rushing P, Scharrer E. Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin. Am J Physiol Regul Integr Comp Physiol. 2001;281:R1442-8 pubmed
    ..the anorectic effect of intraperitoneally injected amylin (5 and 20 microg/kg), the amylin agonist salmon calcitonin (sCT; 10 microg/kg), leptin (1.3 mg/kg), and cholecystokinin (CCK; 20 microg/kg)...
  76. Zhou H, Baraniak A, Lou H. Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing. Mol Cell Biol. 2007;27:830-41 pubmed
    ..elements and protein factors are known to regulate the non-neuronal pathway of alternative processing of the calcitonin/calcitonin gene-related peptide (CGRP) pre-mRNA, the mechanisms controlling the neuron-specific pathway have ..
  77. Katan M, Moon Y, Paik M, Mueller B, Huber A, Sacco R, et al. Procalcitonin and Midregional Proatrial Natriuretic Peptide as Markers of Ischemic Stroke: The Northern Manhattan Study. Stroke. 2016;47:1714-9 pubmed publisher
    ..We hypothesized that selected blood biomarkers of infection (procalcitonin [PCT]), hypothalamic-pituitary-axis function (copeptin), and hemodynamic dysfunction (midregional proatrial natriuretic ..
  78. Li X, Wang X, Li S, Yan J, Li D. Diagnostic Value of Procalcitonin on Early Postoperative Infection After Pediatric Cardiac Surgery. Pediatr Crit Care Med. 2017;18:420-428 pubmed publisher
    ..Continuous procalcitonin monitoring might help to discover infection earlier. ..
  79. Saltiki K, Anagnostou E, Simeakis G, Kouki S, Angelopoulou A, Sarika L, et al. Familial MTC with RET exon 8 Gly533Cys mutation: origin and prevalence of second malignancy. Endocr Connect. 2017;6:676-684 pubmed publisher
    ..Pre-, post-operative calcitonin, disease extent at diagnosis and follow-up and families' place of origin were recorded...
  80. Riley J, Edbrooke M, Craig R. Ectopic synthesis of high-Mr calcitonin by the BEN lung carcinoma cell line reflects aberrant proteolytic processing. FEBS Lett. 1986;198:71-9 pubmed
    Cloning and nucleotide sequence analysis of the human calcitonin mRNA from the BEN lung carcinoma cell line, a cell line known to secrete high-Mr forms of calcitonin, showed no difference in the coding region at the nucleotide level ..
  81. Le Moullec J, Jullienne A, Chenais J, Lasmoles F, Guliana J, Milhaud G, et al. The complete sequence of human preprocalcitonin. FEBS Lett. 1984;167:93-7 pubmed
    ..to mRNA extracted from the thyroid glands of patients suffering from medullary carcinoma of the thyroid (MCT), a calcitonin-producing tumour, was inserted in the Pst site of pBR 322 by G-C tailing...
  82. Findlay D, Sexton P. Calcitonin. Growth Factors. 2004;22:217-24 pubmed
  83. Suzuki K, Kobayashi Y, Morita T. Significance of serum calcitonin gene-related peptide levels in prostate cancer patients receiving hormonal therapy. Urol Int. 2009;82:291-5 pubmed publisher
    b>Calcitonin gene-related peptide (CGRP) is one of the neuroendocrine markers. The serum CGRP levels in untreated prostate cancer (PCa) patients reportedly reflect the tumor volume and aggressiveness...
  84. Gorisek B, Miksić N, Krajnc P, Pakiz M, Turk Z. The role of procalcitonin in gynaecological surgery. J Int Med Res. 2009;37:918-26 pubmed
    ..It is concluded that, for early detection of postoperative infectious complications after gynaecological surgery, procalcitonin levels > 2 ng/ml are more specific than CRP. ..
  85. Mapp P, McWilliams D, Turley M, Hargin E, Walsh D. A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo. Br J Pharmacol. 2012;166:1261-71 pubmed publisher
    We have tested the hypothesis that calcitonin gene-related peptide (CGRP) is a mediator of capsaicin-induced angiogenesis in vivo. In a series of experiments, the knee joints of rats were injected with CGRP, capsaicin or vehicle control...
  86. Bonner K, Pease J, Corrigan C, Clark P, Kay A. CCL17/thymus and activation-regulated chemokine induces calcitonin gene-related peptide in human airway epithelial cells through CCR4. J Allergy Clin Immunol. 2013;132:942-50.e1-3 pubmed publisher
    b>Calcitonin gene-related peptide (CGRP) is a potent arterial and venous vasodilator...
  87. Randhawa P, Jaggi A. A Review on Potential Involvement of TRPV1 Channels in Ischemia-Reperfusion Injury. J Cardiovasc Pharmacol Ther. 2018;23:38-45 pubmed publisher
    ..conditions, activation of TRPV1 channels on the perivascular nerves stimulates the release of calcitonin gene-related peptide and substance P to produce cardioprotection...
  88. Cappagli V, Potes C, Ferreira L, Tavares C, Eloy C, Elisei R, et al. Calcitonin receptor expression in medullary thyroid carcinoma. Peerj. 2017;5:e3778 pubmed publisher
    b>Calcitonin expression is a well-established marker for medullary thyroid carcinoma (MTC); yet the role of calcitonin receptor (CTR), its seven-transmembrane G-protein coupled receptor, remains to be established in C-cells derived thyroid ..
  89. Heffner M, Genetos D, Christiansen B. Bone adaptation to mechanical loading in a mouse model of reduced peripheral sensory nerve function. PLoS ONE. 2017;12:e0187354 pubmed publisher
    ..mechanical loading of bone with sensory nerve activation, we examined whether concentration of the neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) in bone were affected following 1 or 5 days of 5 N tibial ..
  90. Zhang X, Zhang X, Du Y, Xing H, Jia R, Pan L, et al. [Effect of Manual Acupuncture, Electroacupuncture and Moxibustion on Intestinal Motility and Expression of Enteric Nervous Activity Related Proteins in Functional Constipation Rats]. Zhen Ci Yan Jiu. 2017;42:407-12 pubmed
    ..and moxibustion interventions on intestinal motility and expression of enteric nervous activity related proteins calcitonin gene related peptide (CGRP), transient receptor potential vanilloid 1 (TRPV 1) and proteinase activated receptor-..
  91. Jonas V, Lin C, Kawashima E, Semon D, Swanson L, Mermod J, et al. Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression. Proc Natl Acad Sci U S A. 1985;82:1994-8 pubmed
    Two mRNAs generated as a consequence of alternative RNA processing events in expression of the human calcitonin gene encode the protein precursors of either calcitonin or calcitonin gene-related peptide (CGRP)...
  92. Deng T, Yang L, Zheng Z, Li Y, Ren W, Wu C, et al. Calcitonin gene?related peptide induces IL?6 expression in RAW264.7 macrophages mediated by mmu_circRNA_007893. Mol Med Rep. 2017;16:9367-9374 pubmed publisher
    ..to examine the expression of circRNAs and explore their effects on interleukin?6 (IL?6) expression induced by calcitonin gene?related peptide (CGRP) in RAW264.7 macrophages...