Gene Symbol: CACNA1E
Description: calcium voltage-gated channel subunit alpha1 E
Alias: BII, CACH6, CACNL1A6, Cav2.3, gm139, voltage-dependent R-type calcium channel subunit alpha-1E, brain calcium channel II, calcium channel, L type, alpha-1 polypeptide, calcium channel, R type, alpha-1 polypeptide, voltage-dependent calcium channel alpha 1E subunit, voltage-gated calcium channel alpha subunit Cav2.3
Species: human
Products:     CACNA1E

Top Publications

  1. Williams M, Marubio L, Deal C, Hans M, Brust P, Philipson L, et al. Structure and functional characterization of neuronal alpha 1E calcium channel subtypes. J Biol Chem. 1994;269:22347-57 pubmed
    ..Thus, alpha 1E-mediated Ca2+ channels appear to be a pharmacologically distinct class of voltage-activated Ca2+ channels. ..
  2. Pereverzev A, Leroy J, Krieger A, Malécot C, Hescheler J, Pfitzer G, et al. Alternate splicing in the cytosolic II-III loop and the carboxy terminus of human E-type voltage-gated Ca(2+) channels: electrophysiological characterization of isoforms. Mol Cell Neurosci. 2002;21:352-65 pubmed
    ..3 splice variants. ..
  3. Muller Y, Hanson R, Zimmerman C, Harper I, Sutherland J, Kobes S, et al. Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians. Diabetes. 2007;56:3089-94 pubmed
    ..Fine mapping identified single nucleotide polymorphisms (SNPs) near the CACNA1E gene associated with this disease. CACNA1E encodes the voltage-dependent calcium channel Ca(v)2...
  4. Holmkvist J, Tojjar D, Almgren P, Lyssenko V, Lindgren C, Isomaa B, et al. Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion. Diabetologia. 2007;50:2467-75 pubmed
    ..The gene encoding the voltage-dependent Ca(2+) channel Ca(V)2.3 (CACNA1E), telomeric to a region that has shown suggestive linkage to type 2 diabetes (1q21-q25), has been ascribed a role ..
  5. Zhu H, Chen B, Cheng Y, Zhou Y, Yan Y, Luo Q, et al. Insulin Therapy for Gestational Diabetes Mellitus Does Not Fully Protect Offspring From Diet-Induced Metabolic Disorders. Diabetes. 2019;68:696-708 pubmed publisher
    ..It highlights that even efficient insulin therapy for GDM is insufficient to fully protect adult offspring from diet-induced metabolic disorders. ..
  6. Maurer Stroh S, Gao H, Han H, Baeten L, Schymkowitz J, Rousseau F, et al. Motif discovery with data mining in 3D protein structure databases: discovery, validation and prediction of the U-shape zinc binding ("Huf-Zinc") motif. J Bioinform Comput Biol. 2013;11:1340008 pubmed publisher
    ..The Huf-Zinc webserver can be freely accessed through this URL (
  7. Neumaier F, Dibué Adjei M, Hescheler J, Schneider T. Voltage-gated calcium channels: Determinants of channel function and modulation by inorganic cations. Prog Neurobiol. 2015;129:1-36 pubmed publisher
    ..The fact that these ions can often traverse VGCCs can contribute to the detrimental intracellular accumulation of metal ions following excessive release of endogenous Cu(2+) and Zn(2+) or exposure to non-physiological toxic metal ions. ..
  8. Yao Z, Qin Z, Cheng H, Wu X, Dai Y, Wang X, et al. Simultaneous Quantification of Multiple Representative Components in the Xian-Ling-Gu-Bao Capsule by Ultra-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. Molecules. 2017;22: pubmed publisher
    ..VI from Radix Dipsaci, epimedin C, magnoflorine, and icariin from Herba Epimedii as well as timosaponin BII from Rhizoma Anemarrhenae varied significantly in multiple samples, which hinted an assay for these four components ..
  9. Furukawa H, Yamane N, Honda T, Yamasawa T, Kanaoka Y, Tanemoto K. Angiographic appearance of patent saphenous vein grafts more than 25 years after coronary artery bypass grafting. Gen Thorac Cardiovasc Surg. 2018;: pubmed publisher
    ..The other eight grafts exhibited some vein graft disease (BII:3, BIII:5). The sequential anastomosis was performed for 5 SVGs...

More Information

Publications150 found, 100 shown here

  1. Zhang J, Tan L, Ren Y, Liang J, Lin R, Feng Q, et al. Presynaptic Excitation via GABAB Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression. Cell. 2016;166:716-728 pubmed publisher
    ..We identify the role of an extra-amygdalar circuit and presynaptic GABAB receptors in fear control, suggesting that boosting neurotransmission in this pathway might ameliorate some fear disorders. ..
  2. Nguyen M, Sim A, Wan Y, Madhusudhan M, Verma C. Topology independent comparison of RNA 3D structures using the CLICK algorithm. Nucleic Acids Res. 2017;45:e5 pubmed publisher
    ..Rclick can be further extended to identify ligand-binding pockets in RNA. A web server is developed at
  3. Kang G, Yun H, Sun C, Park I, Lee S, Kwon J, et al. Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors. Oncotarget. 2016;7:6538-51 pubmed publisher
    ..We also identified copy number gain and increased mRNA expression of AMACR, CRIM1, SKP2, and CACNA1E. Mapping of copy number and gene expression results to the KEGG pathways revealed activation of the JAK-STAT ..
  4. Wong W, Maurer Stroh S, Schneider G, Eisenhaber F. Transmembrane helix: simple or complex. Nucleic Acids Res. 2012;40:W370-5 pubmed publisher
    ..It is freely accessible at or available for download.
  5. Tamandegani P, Zafari D, Marik T, Szekeres A, Vagvolgyi C, Kredics L. Peptaibol profiles of Iranian Trichoderma isolates. Acta Biol Hung. 2016;67:431-441 pubmed publisher previously reported trichotoxins (trichotoxin A-50s and T5D2) and trichobrachins (longibrachins AI, AII, AIII, BII and BIII)...
  6. Brænne I, Willenborg C, Tragante V, Kessler T, Zeng L, Reiz B, et al. A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors. Sci Rep. 2017;7:10252 pubmed publisher
    ..The lead SNPs were rs7270354 (MMP9), rs4888383 (BCAR1), rs6905288 (VEGFA1), and rs556321 (CACNA1E)...
  7. Jenjaroenpun P, Wongsurawat T, Yenamandra S, Kuznetsov V. QmRLFS-finder: a model, web server and stand-alone tool for prediction and analysis of R-loop forming sequences. Nucleic Acids Res. 2015;43:W527-34 pubmed publisher
    ..QmRLFS-finder is freely available at
  8. Leutgeb V, Schwab D, Scharmüller W, Höfler C, Schienle A. Is this blood? An ERP study on the visual identification of red fluids in patients with blood phobia. Brain Res. 2018;1678:195-202 pubmed publisher
    ..The P100 augmentation in blood phobics very likely reflects enhanced early selective attention. Patients with BII phobia showed prioritized visual processing of blood without having to rely on contextual information.
  9. Wong W, Yap C, Eisenhaber B, Eisenhaber F. dissectHMMER: a HMMER-based score dissection framework that statistically evaluates fold-critical sequence segments for domain fold similarity. Biol Direct. 2015;10:39 pubmed publisher
    ..Finally, dissectHMMER webserver is made publicly available at ...
  10. Villar Pazos S, Martinez Pinna J, Castellano Muñoz M, Alonso Magdalena P, Marroquí L, Quesada I, et al. Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on ca2+ entry in mouse pancreatic β-cells. Sci Rep. 2017;7:11770 pubmed publisher
    ..The outcome of both molecular mechanisms explains the NMDR relationship between BPA and Ca2+ entry in β-cells. ..
  11. Heyne H, Singh T, Stamberger H, Abou Jamra R, Caglayan H, Craiu D, et al. De novo variants in neurodevelopmental disorders with epilepsy. Nat Genet. 2018;50:1048-1053 pubmed publisher
    ..Joint analysis of all individuals with NDDs also implicated CACNA1E as a novel disease-associated gene...
  12. Rodriguez V, Martin J, Sarmiento Vizcaíno A, de la Cruz M, Garcia L, Blanco G, et al. Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169. Mar Drugs. 2018;16: pubmed publisher
    ..of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (3)...
  13. Yap C, Eisenhaber B, Eisenhaber F, Wong W. xHMMER3x2: Utilizing HMMER3's speed and HMMER2's sensitivity and specificity in the glocal alignment mode for improved large-scale protein domain annotation. Biol Direct. 2016;11:63 pubmed
    ..The xHMMER3x2 code and its webserver (for Pfam release 27, 28 and 29) are freely available at . Reviewed by Thomas Dandekar, L. Aravind, Oliviero Carugo and Shamil Sunyaev...
  14. Sun M, Li K, Liu X. Three new species of the subfamily Opisthocosmiinae from China (Dermaptera, Forficulidae), with new synonymies and combinations. Zootaxa. 2016;4109:359-71 pubmed publisher
    ..nov. from Xizang, Timomenus bii sp. nov. from Yunnan and Cordax serratus sp. nov. from Guangxi...
  15. Schneider T, Dibué Adjei M, Neumaier F, Akhtar I, Hescheler J, Kamp M, et al. R-Type Voltage-Gated Ca²⁺ Channels in Cardiac and Neuronal Rhythmogenesis. Curr Mol Pharmacol. 2015;8:102-8 pubmed
    ..been ablated, and their role in cardiac and neuronal pacemaking is compared in the present summary, focusing on the role of murine R-type voltage-gated Ca(2+) channels encoded by cacna1e and expressing the ion conducting subunit Cav2.3.
  16. Ji W, Lin E, Li Q, Wang H. Heteroannulation enabled by a bimetallic Rh(iii)/Ag(i) relay catalysis: application in the total synthesis of aristolactam BII. Chem Commun (Camb). 2017;53:5665-5668 pubmed publisher
    ..The methodology developed was applied as a key step in the rapid total synthesis of the natural product aristolactam BII.
  17. Liu Q, Deng Y, Smith A. Total Synthesis of (-)-Nahuoic Acid Ci (Bii). J Am Chem Soc. 2017;139:13668-13671 pubmed publisher
  18. Jenjaroenpun P, Wongsurawat T, Sutheeworapong S, Kuznetsov V. R-loopDB: a database for R-loop forming sequences (RLFS) and R-loops. Nucleic Acids Res. 2017;45:D119-D127 pubmed publisher
    R-loopDB ( was originally constructed as a collection of computationally predicted R-loop forming sequences (RLFSs) in the human genic regions...
  19. Rosa F, Quero G, Fiorillo C, Doglietto G, Alfieri S. Billroth II reconstruction in gastric cancer surgery: A good option for Western patients. Am J Surg. 2019;: pubmed publisher
    ..The aim of this study is to report the short and long-term results of a cohort of patients who underwent Billroth II (BII) Distal Gastrectomy (DG) for gastric cancer (GC), in a tertiary referral Western center...
  20. Baranova I, Souza A, Bocharov A, Vishnyakova T, Hu X, Vaisman B, et al. Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo. PLoS ONE. 2017;12:e0175824 pubmed publisher
    ..This study provides new evidence that SR-BII, splice variant of SR-BI, could function as an SAA receptor mediating its uptake and pro-inflammatory signaling...
  21. Polyakov A, Mohseni K, Castro G, Rubio Zuazo J, Zeugner A, Isaeva A, et al. A bismuth triiodide monosheet on Bi2Se3(0001). Sci Rep. 2019;9:4052 pubmed publisher
    A stable BiI3 monosheet has been grown for the first time on the (0001) surface of the topological insulator Bi2Se3 as confirmed by scanning tunnelling microscopy, surface X-ray diffraction, and X-ray ..
  22. Akinkuotu O, Takeet M, Otesile E, Olufemi F, Greenwood S, McClure J. Prevalence and multilocus genotypes of Giardia duodenalis infecting pigs in Ogun state, Nigeria. Infect Genet Evol. 2019;70:53-60 pubmed publisher
    ..assemblage B isolates after multiple alignment analyses of the gdh, tpi and bg sequences whereby sub-assemblages BII (n = 2), BIII (n = 9) and BIV (n = 3) were identified...
  23. Smith M, Katsouri L, Virtue S, Choudhury A, Vidal Puig A, Ashford M, et al. Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons. Cell Rep. 2018;25:278-287.e4 pubmed publisher
    ..Knockdown of the pore-forming subunit of the R-type (CaV2.3 or Cacna1e) conductance in hypothalamic POMC neurons prevented sustained leptin-induced depolarization...
  24. Huang C, Yang X, Zeng B, Zeng L, Gong X, Zhou C, et al. Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression. J Proteomics. 2019;194:132-147 pubmed publisher
    ..With that, the down-regulated CACNA1E and its downstream proteins (CALM/ CaMKII/ CREB/ BDNF) in CREB pathway were validated by Western blot...
  25. Hilbert K, Evens R, Maslowski N, Wittchen H, Lueken U. Neurostructural correlates of two subtypes of specific phobia: a voxel-based morphometry study. Psychiatry Res. 2015;231:168-75 pubmed publisher
    The animal and blood-injection-injury (BII) subtypes of specific phobia are both characterized by subjective fear but distinct autonomic reactions to threat...
  26. Sugino S, Farrag M, Ruiz Velasco V. Gα14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons. J Neurophysiol. 2016;115:1577-86 pubmed publisher
    ..Taken together, these results provide evidence of a new Gα14-coupled signaling pathway that modulates CaV2.2 and M-currents via SP-stimulated NK-1 receptors in CSMG neurons. ..
  27. Clemmensen T, Løgstrup B, Eiskjær H, Poulsen S. Evaluation of longitudinal myocardial deformation by 2-dimensional speckle-tracking echocardiography in heart transplant recipients: relation to coronary allograft vasculopathy. J Heart Lung Transplant. 2015;34:195-203 pubmed publisher
    ..The present results suggest GLS as a new method to be included in the monitoring of graft function in relation to CAV. ..
  28. Dennington A, Weller M. Synthesis, structure and optoelectronic properties of hybrid iodobismuthate & iodoantimonate semiconducting materials. Dalton Trans. 2018;47:3469-3484 pubmed publisher
    ..C6H9N2O][SbI4] (I) and [C6H9N2O][BiI4] (II), while 4-methylmorpholinium templates the compounds, [C5H12NO]4[..
  29. Kwon Y, Jung Kim H, Lo Menzo E, Park S, Szomstein S, Rosenthal R. A systematic review and meta-analysis of the effect of Billroth reconstruction on type 2 diabetes: A new perspective on old surgical methods. Surg Obes Relat Dis. 2015;11:1386-95 pubmed publisher
    Studies have reported that Billroth II (BII) reconstruction after subtotal gastrectomy for cancer or intractable ulcers can more effectively improve type 2 diabetes mellitus (T2D) than Billroth I (BI) reconstruction by allowing patients ..
  30. Swaminathan S, Klemm L, Park E, Papaemmanuil E, Ford A, Kweon S, et al. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015;16:766-774 pubmed publisher
    ..Here we identified small pre-BII cells as a natural subset with increased genetic vulnerability owing to concurrent activation of these enzymes...
  31. Kjalarsdottir L, Tersey S, Vishwanath M, Chuang J, Posner B, Mirmira R, et al. 1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor. J Steroid Biochem Mol Biol. 2019;185:17-26 pubmed publisher
    ..Microarray analysis identified the R-type voltage-gated calcium channel (VGCC) gene, Cacna1e, which is highly upregulated by 1,25D3 in human and mouse islets and contains a conserved VDRE in ..
  32. Sánchez Navarro J, Martínez Selva J, Maldonado E, Carrillo Verdejo E, Pineda S, Torrente G. Autonomic reactivity in blood-injection-injury and snake phobia. J Psychosom Res. 2018;115:117-124 pubmed publisher
    ..flow and other autonomic reactions -heart rate (HR) and skin conductance response (SCR)- in blood-injection-injury (BII) phobia and snake phobia participants, under the assumption that exposure to blood-related pictures in BII phobia ..
  33. Rousset M, Cens T, Menard C, Bowerman M, Bellis M, Brusés J, et al. Regulation of neuronal high-voltage activated Ca(V)2 Ca(2+) channels by the small GTPase RhoA. Neuropharmacology. 2015;97:201-9 pubmed publisher
  34. Dans P, Faustino I, Battistini F, Zakrzewska K, Lavery R, Orozco M. Unraveling the sequence-dependent polymorphic behavior of d(CpG) steps in B-DNA. Nucleic Acids Res. 2014;42:11304-20 pubmed publisher
    ..We found that twist polymorphism is coupled with BI/BII transitions, and, quite surprisingly, with slide polymorphism in the neighboring step...
  35. Li G, Tang Z, Yang J, Duan J, Qian D, Guo J, et al. Simultaneous determination of five components in rat plasma by UPLC-MS/MS and its application to a comparative pharmacokinetic study in Baihe Zhimu Tang and Zhimu extract. Molecules. 2015;20:6700-14 pubmed publisher
    ..g., timosaponin BII, anemarsaponin BIII, timosaponin AIII)...
  36. Liu Z, Liu S, Xu G, Feng F, Guo M, Lian X, et al. [Comparison of long-term survival and postoperative complications between Billroth I( and II( reconstruction in patients with distal gastric cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2016;19:785-8 pubmed
    ..and postoperative complications of distal gastric cancer patients between Billroth I((BI() and Billroth II((BII() reconstruction...
  37. Simon E, Meuret A, Ritz T. Sympathetic and parasympathetic cardiac responses to phobia-relevant and disgust-specific emotion provocation in blood-injection-injury phobia with and without fainting history. Psychophysiology. 2017;54:1512-1527 pubmed publisher
    The autonomic regulation in blood-injection-injury (BII) phobia has received particular attention due to the unique link between fear and fainting in this anxiety disorder...
  38. Govil M, Mukhopadhyay N, Weeks D, Feingold E, Shaffer J, Levy S, et al. Novel caries loci in children and adults implicated by genome-wide analysis of families. BMC Oral Health. 2018;18:98 pubmed publisher
    ..Genes with a potential role in dental caries in the eight chromosomal regions include CACNA1E, LAMC2, ALMS1, STAMBP, GXYLT2, SLC12A2, MEGF10, TMEM181, ARID1B, and, as well as genes in several immune gene ..
  39. Bonzi J, Bornet O, Betzi S, Kasper B, Mahal L, Mancini S, et al. Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions. Nat Commun. 2015;6:6194 pubmed publisher
    ..B-cell development, bone marrow stromal cells secreting galectin-1 (GAL1) constitute a specific niche for pre-BII cells...
  40. Karolak A, van der Vaart A. BII stability and base step flexibility of N6-adenine methylated GATC motifs. Biophys Chem. 2015;203-204:22-7 pubmed publisher
    ..While the effect was small, more frequent BI to BII conversions were observed in the GA step of hemimethylated DNA...
  41. Cavazzini F, Campioni D, Ferrari L, Buldini B, Bardi M, Michielotto B, et al. Expression of the immunoglobulin superfamily cell membrane adhesion molecule Cd146 in acute leukemia. Cytometry B Clin Cytom. 2016;90:247-56 pubmed publisher
    ..Among B-ALL CD146-positive cases, 78.6% were associated with a "common"/BII-ALL and 21...
  42. Yu R, Seymour V, Berecki G, Jia X, Akcan M, Adams D, et al. Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Sci Rep. 2015;5:13264 pubmed publisher
    ..Because it has only one disulfide bond, hcVc1.1 is not subject to disulfide bond shuffling and does not form multiple isomers during peptide synthesis. ..
  43. Sheikh F, Fallon S, Bisset G, Podberesky D, Zheng J, Orth R, et al. Image-guided prediction of pseudocyst formation in pediatric pancreatic trauma. J Surg Res. 2015;193:513-8 pubmed publisher
    ..pseudocysts occurred in 0/20 patients with grade A injuries, 2/17 (12%) with BI/CI injuries, and 9/15 (60%) with BII/CII injuries...
  44. Gandla J, Lomada S, Lu J, Kuner R, Bali K. miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels. Pain. 2017;158:1765-1779 pubmed publisher
    ..The current study facilitates a deeper understanding of molecular mechanisms underlying cancer pain and suggests a potential for novel therapeutic strategies targeting miR-34c-5p and Cav2.3 in cancer pain. ..
  45. Kim M, Jung H, Kim S, Park J, Seo Y. Electromagnetic fields and nanomagnetic particles increase the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Int J Mol Med. 2015;35:153-60 pubmed publisher
    ..Furthermore, the mRNA expression of calcium channels (CACNA1C, CACNA1E, CACNA1G and CACNA1I) was activated during osteogenic differentiation...
  46. Garofalo F, Abouzahr O, Atlas H, Denis R, Garneau P, Huynh H, et al. Laparoscopic revision of Billroth II with Braun anastomosis into Roux-en-Y anatomy in a patient with intestinal malrotation. Surg Endosc. 2018;32:511 pubmed publisher
    ..Among these, a Billroth II (BII) anastomosis can be performed with the addition of the Omega entero-enterostomy that may theoretically reduce the ..
  47. Ashokkumar A, Enyashin A, Deepak F. Single Walled BiI3 Nanotubes Encapsulated within Carbon Nanotubes. Sci Rep. 2018;8:10133 pubmed publisher
    ..a simple route to obtain inorganic single walled nanotubes - a novel ultrathin morphology for bismuth iodide (BiI3), embedded within CNTs...
  48. Zheng Z, Goncearenco A, Berezovsky I. Nucleotide binding database NBDB--a collection of sequence motifs with specific protein-ligand interactions. Nucleic Acids Res. 2016;44:D301-7 pubmed publisher
    ..The database is freely available online at In total, NBDB contains data on 249 motifs that work in interactions with 24 ligands...
  49. Cheng R, Azarbal B, Yung A, Patel J, Chang D, Liou F, et al. Elevated immune monitoring as measured by increased adenosine triphosphate production in activated lymphocytes is associated with accelerated development of cardiac allograft vasculopathy after cardiac transplantation. J Heart Lung Transplant. 2016;35:1018-23 pubmed publisher
    ..647, confidence interval 1.020 to 2.661, p = 0.041). Elevated peak IM, as measured by increased ATP production, in activated lymphocytes is associated with decreased freedom from angiographic CAV. ..
  50. Tompkins J, Merriam L, Girard B, May V, Parsons R. Nickel suppresses the PACAP-induced increase in guinea pig cardiac neuron excitability. Am J Physiol Cell Physiol. 2015;308:C857-66 pubmed publisher
    ..Together, our results suggest that a PACAP-enhanced, Ni(2+)-sensitive current contributes to PACAP-induced modulation of neuronal excitability. ..
  51. Shiba K, Taneichi H, Namikawa T, Inami S, Takeuchi D, Nohara Y. Osseointegration improves bone-implant interface of pedicle screws in the growing spine: a biomechanical and histological study using an in vivo immature porcine model. Eur Spine J. 2017;26:2754-2762 pubmed publisher
    ..Osseointegration showing biomechanical and histological improvement in bone-implant interface (BII) after dental implant placement has been well investigated...
  52. Hu X, Wang L, Xiang G, Lei W, Feng Y. Angiogenesis impairment by the NADPH oxidase-triggered oxidative stress at the bone-implant interface: Critical mechanisms and therapeutic targets for implant failure under hyperglycemic conditions in diabetes. Acta Biomater. 2018;73:470-487 pubmed publisher
    ..Here, we studied the role of angiogenesis in the diabetes-induced poor bone repair at the bone-implant interface (BII) and the related mechanisms...
  53. Berecki G, Motin L, Adams D. Voltage-Gated R-Type Calcium Channel Inhibition via Human μ-, δ-, and κ-opioid Receptors Is Voltage-Independently Mediated by Gβγ Protein Subunits. Mol Pharmacol. 2016;89:187-96 pubmed publisher
    ..3 channels as potential targets for opioid analgesics. Their novel modulation is dependent on pre-existing OR activity and mediated by membrane-delimited Gβγ subunits in a voltage-independent manner. ..
  54. Li Y, Bai W, Zhang X. Identifying heterogeneous subtypes of gastric cancer and subtype?specific subpaths of microRNA?target pathways. Mol Med Rep. 2018;17:3583-3590 pubmed publisher
    ..indicated that the subpath related to subtype 1 was miRNA (miR)?202/calcium voltage?gated channel subunit ?1 (CACNA1E)/type II diabetes mellitus...
  55. Nakahara K, Okuse C, Suetani K, Morita R, Michikawa Y, Ozawa S, et al. Endoscopic retrograde cholangiography using an anterior oblique-viewing endoscope in patients with altered gastrointestinal anatomy. Dig Dis Sci. 2015;60:944-50 pubmed publisher
    ..Reconstruction consisted of Billroth II gastrectomy (BII) in 25 patients (30 procedures) and Roux-en-Y anastomosis (RY) in 15 patients (20 procedures)...
  56. Drobinskaya I, Neumaier F, Pereverzev A, Hescheler J, Schneider T. Diethyldithiocarbamate-mediated zinc ion chelation reveals role of Cav2.3 channels in glucagon secretion. Biochim Biophys Acta. 2015;1853:953-64 pubmed publisher
    ..Especially under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis. ..
  57. Alnasser H, Guan Q, Zhang F, Gleave M, Nguan C, Du C. Requirement of clusterin expression for prosurvival autophagy in hypoxic kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2016;310:F160-73 pubmed publisher
    ..Autophagy was determined by either light chain 3-BII expression with Western blot analysis or light chain 3-green fluorescent protein aggregation with confocal ..
  58. Licon Y, Leandro D, Romero Méndez C, Rodríguez Menchaca A, Sánchez Armass S, Meza U. Inhibition of CaV2.3 channels by NK1 receptors is sensitive to membrane cholesterol but insensitive to caveolin-1. Pflugers Arch. 2015;467:1699-709 pubmed publisher
    ..Raft-dependent modulation of CaV2.3 could be important in the physiological and pathophysiological processes in which these channels participate, including neuronal excitability, synaptic plasticity, epilepsy, and chronic pain. ..
  59. Oar E, Farrell L, Waters A, Ollendick T. Blood-Injection-Injury Phobia and Dog Phobia in Youth: Psychological Characteristics and Associated Features in a Clinical Sample. Behav Ther. 2016;47:312-24 pubmed publisher
    Blood-Injection-Injury (BII) phobia is a particularly debilitating condition that has been largely ignored in the child literature...
  60. Scholz M, Oum K, Lenzer T. Pronounced exciton and coherent phonon dynamics in BiI3. Phys Chem Chem Phys. 2018;20:10677-10685 pubmed publisher
  61. Garraud O, Sut C, Haddad A, Tariket S, Aloui C, Laradi S, et al. Transfusion-associated hazards: A revisit of their presentation. Transfus Clin Biol. 2018;25:118-135 pubmed publisher far, it appears that TAHs can be analysed using different approaches: (bi) their pathophysiological nature; (bii) their severity; (biii) the onset scheme; (biv) a quality assessment (preventable or non-preventable); (bv) their ..
  62. Ho G. Contribution to the knowledge of Chinese Phasmatodea IV: Taxonomy on Medaurini (Phasmatodea: Phasmatidae: Clitumninae) of China. Zootaxa. 2017;4365:501-546 pubmed publisher
    ..They are Cnipsomorpha bii sp. nov., C. daliensis sp. nov., C. maoershanensis sp. nov., C. wenxuani sp. nov...
  63. Chen W, Yuan Y, Zhu Z, Jiang Z, Su S, Liao L, et al. De novo design of D-?-A molecules as universal hosts for monochrome and white phosphorescent organic light-emitting diodes. Chem Sci. 2018;9:4062-4070 pubmed publisher
    ..D-?-A host materials 11,11-bis(9-phenyl-9H-carbazol-3-yl)-11H-benzo[4,5]imidazo[1,2-a]indole (BII-BCz) and 4,4'-(11H-benzo[4,5]imidazo[1,2-a]indole-11,11-diyl)bis(N,N-diphenylaniline) (..
  64. Cvetković A, Milasinovic D, Peulic A, Mijailovic N, Filipovic N, Zdravkovic N. Numerical and experimental analysis of factors leading to suture dehiscence after Billroth II gastric resection. Comput Methods Programs Biomed. 2014;117:71-9 pubmed publisher
    The main goal of this study was to numerically quantify risk of duodenal stump blowout after Billroth II (BII) gastric resection...
  65. Jenjaroenpun P, Chew C, Yong T, Choowongkomon K, Thammasorn W, Kuznetsov V. The TTSMI database: a catalog of triplex target DNA sites associated with genes and regulatory elements in the human genome. Nucleic Acids Res. 2015;43:D110-6 pubmed publisher
    ..Here, we present the TTS Mapping and Integration (TTSMI;
  66. Kumar D, Dedic N, Flachskamm C, Voulé S, Deussing J, Kimura M. Cacna1c (Cav1.2) Modulates Electroencephalographic Rhythm and Rapid Eye Movement Sleep Recovery. Sleep. 2015;38:1371-80 pubmed publisher
    ..Lower spectral gamma activity, slightly increased sleep demands, and altered REM sleep responses found in heterozygous Cacna1c knockout mice may rather resemble a sleep phenotype observed in schizophrenia patients. ..
  67. Baranova I, Souza A, Bocharov A, Vishnyakova T, Hu X, Vaisman B, et al. Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice. J Immunol. 2016;196:3135-47 pubmed publisher
    The class B scavenger receptors BI (SR-BI) and BII (SR-BII) are high-density lipoprotein receptors that recognize various pathogens, including bacteria and their products...
  68. Alcaraz A, Carballido Rodríguez J, Unda Urzaiz M, Medina Lopez R, Ruiz Cerdá J, Rodríguez Rubio F, et al. Quality of life in patients with lower urinary tract symptoms associated with BPH: change over time in real-life practice according to treatment--the QUALIPROST study. Int Urol Nephrol. 2016;48:645-56 pubmed publisher
    ..QoL and symptoms were measured at baseline and 6 months using the Benign Prostatic Hyperplasia Impact Index (BII) and the IPSS. 1713 patients were included for analysis. Mean (SD) IPSS and BII scores at baseline were 16.8 (5...
  69. Samanta S, Raghunathan D, Mukherjee S. Effect of temperature on the structure and hydration layer of TATA-box DNA: A molecular dynamics simulation study. J Mol Graph Model. 2016;66:9-19 pubmed publisher
    ..within the studied range of temperatures, but significant structural alteration was noticed between BI and BII forms at higher temperature...
  70. Nian S, Li H, Liu E, Li P. Comparison of ?-glucosidase inhibitory effect and bioactive constituents of Anemarrhenae Rhizoma and Fibrous Roots. J Pharm Biomed Anal. 2017;145:195-202 pubmed publisher
    ..quantification of seven bioactive constituents including neomangiferin, mangiferin, isomangiferin, timosaponin BII, timosaponin B, timosaponin AIII, and timosaponin N in 40 batches of samples...
  71. McVary K, Peterson A, Donatucci C, Baygani S, Henneges C, Clouth J, et al. Use of Structural Equation Modeling to Demonstrate the Differential Impact of Storage and Voiding Lower Urinary Tract Symptoms on Symptom Bother and Quality of Life during Treatment for Lower Urinary Tract Symptoms Associated with Benign Prostatic Hy. J Urol. 2016;196:824-30 pubmed publisher
    ..measured by I-PSS storage vs voiding subscore questions and measure the magnitude of effects on bother using BII (Benign Prostatic Hyperplasia Impact Index) and quality of life on I-PSS quality of life questions...
  72. Wang Y, Li Z, Shan F, Zhang L, Li S, Jia Y, et al. [Comparison of the safety and the costs between laparoscopic assisted or totally laparoscopic uncut Roux-en-Y and BillrothII(+Braun reconstruction--a single center prospective cohort study]. Zhonghua Wei Chang Wai Ke Za Zhi. 2018;21:312-317 pubmed
    ..short-term safety and costs between laparoscopic assisted or totally laparoscopic uncut Roux-en-Y and Billroth II((BII() + Braun reconstruction after radical gastrectomy of distal gastric cancer...
  73. Wang K, Kelley M, Wu W, Adelman J, Maylie J. Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice. PLoS ONE. 2015;10:e0139332 pubmed publisher
    ..2-containing channels to CaV2.3 channels to provide negative feedback regulation of EPSPs in the spines of CA1 pyramidal neurons. ..
  74. Xie L, Dolai S, Kang Y, Liang T, Xie H, Qin T, et al. Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells. PLoS ONE. 2016;11:e0147862 pubmed publisher
    ..We conclude that Syn-3 may mimic Syn-1A in the ability to bind and modulate Cavs, but preferring Cav2.3 to perhaps participate in triggering fusion of newcomer insulin SGs during second-phase GSIS. ..
  75. Tang Z, Li G, Yang J, Duan J, Qian D, Guo J, et al. Anemarrhena asphodeloides Non-Steroidal Saponin Components Alter the Pharmacokinetic Profile of Its Steroidal Saponins in Rat. Molecules. 2015;20:11777-92 pubmed publisher
    ..At different time points, the concentration of timosaponin BII, anemarsaponin BIII, timosaponin AIII and timosaponin E1 in rat plasma were determined and main pharmacokinetic ..
  76. Michałowski J, Matuszewski J, Droździel D, Koziejowski W, Rynkiewicz A, Jednoróg K, et al. Neural response patterns in spider, blood-injection-injury and social fearful individuals: new insights from a simultaneous EEG/ECG-fMRI study. Brain Imaging Behav. 2017;11:829-845 pubmed publisher
    ..the brain responses and the cardiac activity during fear picture processing between spider, blood-injection-injury (BII) and social fearful as well as healthy (non-fearful) volunteers...
  77. Bocharov A, Wu T, Baranova I, Birukova A, Sviridov D, Vishnyakova T, et al. Synthetic Amphipathic Helical Peptides Targeting CD36 Attenuate Lipopolysaccharide-Induced Inflammation and Acute Lung Injury. J Immunol. 2016;197:611-9 pubmed publisher
    ..SAHPs) designed as apolipoprotein A-I mimetics are known to bind to class B scavenger receptors (SR-Bs), SR-BI, SR-BII, and CD36, receptors that mediate lipid transport and facilitate pathogen recognition...
  78. Siapich S, Akhtar I, Hescheler J, Schneider T, Lüke M. Low concentrations of ethanol but not of dimethyl sulfoxide (DMSO) impair reciprocal retinal signal transduction. Graefes Arch Clin Exp Ophthalmol. 2015;253:1713-9 pubmed publisher
    ..Ethanol itself but not DMSO may block GABA receptors and cause an amplitude increase by itself, so that reciprocal signaling is impaired. ..
  79. Roehrborn C, Oyarzabal Pérez I, Roos E, Calomfirescu N, Brotherton B, Palacios J, et al. Can we use baseline characteristics to assess which men with moderately symptomatic benign prostatic hyperplasia at risk of progression will benefit from treatment? A post hoc analysis of data from the 2-year CONDUCT study. World J Urol. 2017;35:421-427 pubmed publisher
    ..Improvements in symptoms (change in IPSS) and quality of life [measured by BPH Impact Index (BII) and question 8 of the IPSS (IPSS-Q8)] were analysed in the FDC group, men who initiated tamsulosin (WW-TAM) and ..
  80. Glowka T, Webler M, Matthaei H, Schäfer N, Schmitz V, Kalff J, et al. Delayed gastric emptying following pancreatoduodenectomy with alimentary reconstruction according to Roux-en-Y or Billroth-II. BMC Surg. 2017;17:24 pubmed publisher
    ..We included 168 consecutive patients who underwent PD with PG with either Billroth II type (BII, n?=?78) or Roux-en-Y type reconstruction (ReY, n?=?90) between 2004 and 2015...
  81. Lopez Fernandez M, Romero Gonzalez M, Günther A, Solari P, Merroun M. Effect of U(VI) aqueous speciation on the binding of uranium by the cell surface of Rhodotorula mucilaginosa, a natural yeast isolate from bentonites. Chemosphere. 2018;199:351-360 pubmed publisher
    ..U-hydroxo-carbonates) on the interaction of this radionuclide with the cells of the yeast Rhodotorula mucigilanosa BII-R8...
  82. Abdelhafez M, Frimberger E, Klare P, Haller B, Schmid R, von Delius S. Comparison of endoscopic sphincterotomy techniques after Billroth II gastrectomy using a novel mechanical simulator. Surg Endosc. 2017;31:5342-5347 pubmed publisher
    ..Ten expert endoscopists performed 6 different EST techniques on a novel mechanical Billroth II (BII) simulator in a random sequence...
  83. Oar E, Farrell L, Waters A, Conlon E, Ollendick T. One session treatment for pediatric blood-injection-injury phobia: A controlled multiple baseline trial. Behav Res Ther. 2015;73:131-42 pubmed publisher
    ..Treatment (OST), which included an e-therapy homework maintenance program over 4 weeks for Blood-Injection-Injury (BII) phobia in children and adolescents...
  84. Karnowski A, Cao C, Matthias G, Carotta S, Corcoran L, Martensson I, et al. Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1. PLoS ONE. 2008;3:e3568 pubmed publisher
    ..In mice deficient for Aiolos and OBF-1, the numbers of immature B cells are reduced, small pre-BII cells are increased and a significant impairment in immunoglobulin light chain DNA rearrangement is observed...
  85. Ku C, Lee N, Hong J, Kwon I, Hyung W, Noh S, et al. Intestinal Glycolysis Visualized by FDG PET/CT Correlates With Glucose Decrement After Gastrectomy. Diabetes. 2017;66:385-391 pubmed publisher
    ..TLG was assessed with regard to surgical method (Billroth I, Billroth II [BII], Roux-en-Y [RY]), fasting glucose decrement (?10 mg/dL), and other clinical factors...
  86. Park S, Min S, Kang H, Lee J. Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3. Biochim Biophys Acta. 2015;1848:2092-100 pubmed publisher
    ..2. In overall, we provide evidence that Cav1.2 and Cav1.3 isoforms are capable of potentially functioning as zinc permeation routes, through which zinc entry can be differentially augmented by mild acidifications. ..
  87. Simmons M, Sudek S, Monier A, Limardo A, Jiménez V, Perle C, et al. Abundance and Biogeography of Picoprasinophyte Ecotypes and Other Phytoplankton in the Eastern North Pacific Ocean. Appl Environ Microbiol. 2016;82:1693-1705 pubmed publisher
    ..that two Bathycoccus ecotypes exist, named here BI (represented by coastal isolate Bathycoccus prasinos) and BII. These share 82% ± 6% nucleotide identity across homologs, while the Ostreococcus spp. share 75% ± 8%...
  88. Neumaier F, Alpdogan S, Hescheler J, Schneider T. Protein phosphorylation maintains the normal function of cloned human Cav2.3 channels. J Gen Physiol. 2018;: pubmed publisher
    ..As such, the present study provides a reliable baseline for further studies on Cav2.3 channel regulation by protein kinases, phosphatases, and possibly proteases. ..
  89. Schneider T, Wei X, Olcese R, Costantin J, Neely A, Palade P, et al. Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit. Receptors Channels. 1994;2:255-70 pubmed
    ..frame, encoding 2,312 amino acids, has high homology to the marine ray doe-1, the rat E-type, and the rabbit brain BII alpha 1 subunits. The amino and carboxy termini of this human...
  90. Adams M, Kerlavage A, Fields C, Venter J. 3,400 new expressed sequence tags identify diversity of transcripts in human brain. Nat Genet. 1993;4:256-67 pubmed
    ..About half of the ESTs predicted to contain a protein-coding region have no matches in the public peptide databases and may represent new gene families. ..
  91. McNaughton N, Green P, Randall A. Inhibition of human alpha1E subunit-mediated ca2+ channels by the antipsychotic agent chlorpromazine. Acta Physiol Scand. 2001;173:401-8 pubmed
    ..These results are discussed with regard to the possible clinical mechanisms of chlorpromazine actions. ..
  92. Natrajan R, Little S, Reis Filho J, Hing L, Messahel B, Grundy P, et al. Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors. Clin Cancer Res. 2006;12:7284-93 pubmed
    ..Microarray-based comparative genomic hybridization identified a microamplification harboring a single gene (CACNA1E) at 1q25.3 in 6 of 76 (7.9%) Wilms' tumors, correlating with a shorter relapse-free survival (P = 0...