Gene Symbol: CA2
Description: carbonic anhydrase 2
Alias: CA-II, CAC, CAII, Car2, HEL-76, HEL-S-282, carbonic anhydrase 2, carbonate dehydratase II, carbonic anhydrase B, carbonic anhydrase C, carbonic anhydrase II, carbonic dehydratase, epididymis luminal protein 76, epididymis secretory protein Li 282
Species: human
Products:     CA2

Top Publications

  1. Sly W, Hu P. Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995;64:375-401 pubmed
    ..Analyses of human and animal CA deficiencies provide unique opportunities to understand the individual contributions of different isozymes to these processes. ..
  2. Li X, Alvarez B, Casey J, Reithmeier R, Fliegel L. Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger. J Biol Chem. 2002;277:36085-91 pubmed
    We examined the ability of carbonic anhydrase II to bind to and affect the transport efficiency of the NHE1 isoform of the mammalian Na(+)/H(+) exchanger...
  3. Alsharidi A, Al Hamed M, Alsuwaida A. Carbonic anhydrase II deficiency: report of a novel mutation. CEN Case Rep. 2016;5:108-112 pubmed publisher
    b>Carbonic anhydrase II (CAII) deficiency is an autosomal recessive disorder characterized by renal tubular acidosis, osteopetrosis, recurrent bone fractures, renal stones, growth failure, and mental retardation...
  4. Theparambil S, Naoshin Z, Thyssen A, Deitmer J. Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes. J Physiol. 2015;593:3533-47 pubmed publisher
    ..After CA inhibition or in CAII-knockout (KO) cells, the rate of recovery was reduced by 40%, and even by 70% in the nominal absence of CO2 /HCO3 (-..
  5. Ueta M, Sotozono C, Kinoshita S. Expression of interleukin-4 receptor ? in human corneal epithelial cells. Jpn J Ophthalmol. 2011;55:405-410 pubmed publisher
    ..tumor necrosis factor alpha-induced protein 6 (TNFAIP6), RAS guanyl-releasing protein 1 (RASGRP1), carbonic anhydrase II (CA2), cytokine-inducible SH2-containing protein (CISH), hyaluronan synthase 3 (HAS3), calpain 14 (CAPN14),..
  6. Pollard A, Shephard F, Freed J, Liddell S, Chakrabarti L. Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration. Aging (Albany NY). 2016;8:2425-2436 pubmed publisher
    ..Mitochondrial carbonic anhydrase II was measured in the Purkinje cell degeneration (pcd5J) mouse model...
  7. Bagnis C, Marshansky V, Breton S, Brown D. Remodeling the cellular profile of collecting ducts by chronic carbonic anhydrase inhibition. Am J Physiol Renal Physiol. 2001;280:F437-48 pubmed
    ..However, we have shown previously that carbonic anhydrase II (CAII)-deficient mice have no IC in their medullary collecting ducts, suggesting a potential role for this ..
  8. Wu M, Ai W, Chen L, Zhao S, Liu E. Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice. Int J Mol Med. 2016;37:565-74 pubmed publisher
    ..ALP)] were decreased, while those of bone resorption-related genes [matrix metalloproteinase (MMP)9 and carbonic anhydrase II (CAII)] were increased...
  9. Hanff E, Zinke M, Böhmer A, Niebuhr J, Maassen M, Endeward V, et al. GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV. Anal Biochem. 2018;550:132-136 pubmed publisher
    ..Renal CAII and CAIV are involved in the reabsorption of nitrite, the autoxidation product of the signalling molecule nitric ..

More Information

Publications153 found, 100 shown here

  1. Theparambil S, Deitmer J. High effective cytosolic H+ buffering in mouse cortical astrocytes attributable to fast bicarbonate transport. Glia. 2015;63:1581-94 pubmed publisher
    ..H(+) buffering, but also rapid import of HCO3(-) via the electrogenic sodium-bicarbonate cotransporter NBCe1, supported by carbonic anhydrase II (CA II), was identified to enhance cytosolic H(+) buffer strength substantially.
  2. Castillo L, Guerrero C, Acosta O. Expression of typical osteoclast markers by PBMCs after PEG-induced fusion as a model for studying osteoclast differentiation. J Mol Histol. 2017;48:169-185 pubmed publisher
    ..PEG-fused PBMCs expressed additional markers compatible with osteoclastogenic differentiation such as carbonic anhydrase II (CAII), calcitonin receptor (CR), cathepsin K (Cat K), vacuolar ATPase (V-ATPase) subunit C1 (V-ATPase), ..
  3. Taylor L, Arnér K, Ghosh F. First responders: dynamics of pre-gliotic Müller cell responses in the isolated adult rat retina. Curr Eye Res. 2015;40:1245-60 pubmed publisher
    ..synthetase (GS), cellular retinaldehyde binding protein (CRALBP), basic fibroblast growth factor (bFGF), carbonic anhydrase II (CAII)) using immunohistochemistry...
  4. Xu J, Barone S, Brooks M, Soleimani M. Double knockout of carbonic anhydrase II (CAII) and Na(+)-Cl(-) cotransporter (NCC) causes salt wasting and volume depletion. Cell Physiol Biochem. 2013;32:173-83 pubmed publisher
    ..b>Carbonic anhydrase II (CAII, CA2 or CAR2) plays an important role in acid-base transport and salt reabsorption in the proximal ..
  5. Simpson J, Walker N, Supuran C, Soleimani M, Clarke L. Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium. Am J Physiol Gastrointest Liver Physiol. 2010;298:G683-91 pubmed publisher
    ..Pat-1 interacts with carbonic anhydrase II (CAII), and studies using CAII(-) intestine or the pharmacological inhibitor methazolamide on WT intestine ..
  6. Zhao D, Li X, Zhao Y, Qiao P, Tang D, Chen Y, et al. Oleanolic acid exerts bone protective effects in ovariectomized mice by inhibiting osteoclastogenesis. J Pharmacol Sci. 2018;137:76-85 pubmed publisher
    ..matrix metalloproteinase 9 (MMP9), Cathepsin K(Ctsk), tartrate-resistant acid phosphatase (TRAP) and carbonic anhydrase II (Car2)...
  7. Wang Q, Zhao Y, Sha N, Zhang Y, Li C, Zhang H, et al. The systemic bone protective effects of Gushukang granules in ovariectomized mice by inhibiting osteoclastogenesis and stimulating osteoblastogenesis. J Pharmacol Sci. 2018;136:155-164 pubmed publisher
    ..bone resorbed genetic expression of matrix metalloproteinase 9 (MMP9), cathepsin K (Ctsk), TRAP and carbonic anhydrase II (Car2)...
  8. Bernhardt A, Koperski K, Schumacher M, Gelinsky M. Relevance of osteoclast-specific enzyme activities in cell-based in vitro resorption assays. Eur Cell Mater. 2017;33:28-42 pubmed publisher
    ..materials was investigated and correlated with the activity of tartrate resistant acid phosphatase (TRAP), carbonic anhydrase II (CAII) and cathepsin K (CTSK)...
  9. Marcoline F, Ishida Y, Mindell J, Nayak S, Grabe M. A mathematical model of osteoclast acidification during bone resorption. Bone. 2016;93:167-180 pubmed publisher
    ..Hence, proton buffering and production in the cytoplasm by carbonic anhydrase II (CAII) is potentially important for proper acidification...
  10. Cuoghi I, Lazzaretti C, Mandrioli M, Mola L, Pederzoli A. Immunohistochemical analysis of the distribution of molecules involved in ionic and pH regulation in the lancelet Branchiostoma floridae (Hubbs, 1922). Acta Histochem. 2018;120:33-40 pubmed publisher
    The aim of present work is to analyse the distribution of carbonic anhydrase II (CAII), cystic fibrosis transmembrane regulator (CFTR), vacuolar-type H+-ATPase (V-H+-ATPase), Na+/K+ ATPase, Na<..
  11. Idrees D, Hadianawala M, Mahapatra A, Datta B, Roy S, Ahamad S, et al. Implication of sulfonylurea derivatives as prospective inhibitors of human carbonic anhydrase II. Int J Biol Macromol. 2018;115:961-969 pubmed publisher
    ..with different pendant moieties in the sulfonylurea derivatives show significant interactions with human carbonic anhydrase II (CAII)...
  12. Guo L, Inada A, Aguayo Mazzucato C, Hollister Lock J, Fujitani Y, Weir G, et al. PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation. Diabetes. 2013;62:3459-68 pubmed publisher
    ..b>Carbonic anhydrase II (CAII)(Cre);Pdx1(Fl) mice were euglycemic for the first 2 postnatal weeks but showed moderate ..
  13. do Nascimento Pedrosa T, De Vuyst E, Mound A, Lambert de Rouvroit C, Maria Engler S, Poumay Y. Methyl-β-cyclodextrin treatment combined to incubation with interleukin-4 reproduces major features of atopic dermatitis in a 3D-culture model. Arch Dermatol Res. 2017;309:63-69 pubmed publisher
    ..b>Carbonic anhydrase II (CA2) and hyaluronan synthase 3 (HAS3), two other markers up-regulated in AD, were also induced when Mβ..
  14. Malec V, Coulson J, Urbé S, Clague M. Combined Analyses of the VHL and Hypoxia Signaling Axes in an Isogenic Pairing of Renal Clear Cell Carcinoma Cells. J Proteome Res. 2015;14:5263-72 pubmed publisher
    ..down-regulation of linked-components associated with the Jacobs-Stewart cycle, including the intracellular carbonic anhydrase II (CA2), which governs cellular response to CO2 fluctuations that often accompany hypoxia in tumors...
  15. Huang C, Lin C, Lin H. Development of gas exchange and ion regulation in two species of air-breathing fish, Betta splendens and Macropodus opercularis. Comp Biochem Physiol A Mol Integr Physiol. 2015;185:24-32 pubmed publisher
    ..of the gills and the labyrinth organ under different levels of oxygen uptake stress, the levels of carbonic anhydrase II (CAII) and Na(+)/K(+)-ATPase (NKA) protein expressions in 2 gills and the labyrinth organ were examined in ..
  16. Wu L, Bernal G, Cahill K, Pytel P, Fitzpatrick C, Mashek H, et al. BCL3 expression promotes resistance to alkylating chemotherapy in gliomas. Sci Transl Med. 2018;10: pubmed publisher
    ..b>Carbonic anhydrase II (CAII) was identified as a downstream factor promoting BCL-3-mediated resistance to chemotherapy...
  17. Adamus G, Yang S, Weleber R. Unique epitopes for carbonic anhydrase II autoantibodies related to autoimmune retinopathy and cancer-associated retinopathy. Exp Eye Res. 2016;147:161-168 pubmed publisher
    High titers of anti-carbonic anhydrase II (anti-CA II) autoantibodies were detected in sera of patients with autoimmune retinopathies (AR), including cancer-associated retinopathy (CAR) and also in normal population...
  18. Poli G, Jha V, Martinelli A, Supuran C, Tuccinardi T. Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors. Int J Mol Sci. 2018;19: pubmed publisher
    b>Carbonic anhydrase II (CAII) is a zinc-containing metalloenzyme whose aberrant activity is associated with various diseases such as glaucoma, osteoporosis, and different types of tumors; therefore, the development of CAII inhibitors, ..
  19. Noor S, Dietz S, Heidtmann H, Boone C, McKenna R, Deitmer J, et al. Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II. J Biol Chem. 2015;290:4476-86 pubmed publisher
    ..We have reported previously that carbonic anhydrase II augments transport activity of MCT1 and MCT4 by a noncatalytic mechanism, while leaving transport activity ..
  20. Dunn I, Joseph N, Bain M, Edmond A, Wilson P, Milona P, et al. Polymorphisms in eggshell organic matrix genes are associated with eggshell quality measurements in pedigree Rhode Island Red hens. Anim Genet. 2009;40:110-4 pubmed publisher well as key genes in the maintenance and function of the shell gland [estrogen receptor (ESR1) and carbonic anhydrase II (CAII)]...
  21. Li H, Chen L, Zhang M, Zhang B. Cells in 3D-reconstitutued eccrine sweat gland cell spheroids differentiate into gross cystic disease fluid protein 15-expressing dark secretory cells and carbonic anhydrase II-expressing clear secretory cells. Acta Histochem. 2017;119:620-623 pubmed publisher
    ..cell spheroids using the dark secretory cell-specific marker, GCDFP-15, and clear secretory cell-specific marker, CAII by immunofluorescence staining...
  22. Noor S, Pouyssegur J, Deitmer J, Becker H. Integration of a 'proton antenna' facilitates transport activity of the monocarboxylate transporter MCT4. FEBS J. 2017;284:149-162 pubmed publisher
    ..We have shown previously that transport activity of MCT4 is enhanced by carbonic anhydrase II (CAII), which has been suggested to function as a 'proton antenna' for the transporter...
  23. Wang Y, Roose B, Philbin J, Doman J, Dmochowski I. Programming A Molecular Relay for Ultrasensitive Biodetection through (129)Xe NMR. Angew Chem Int Ed Engl. 2016;55:1733-6 pubmed publisher
    ..The protein analyte recruits the TFG and frees CB[6] for Xe binding. TFGs containing CB[6]- and carbonic anhydrase II (CAII)-binding domains were synthesized in one or two steps...
  24. Valero T. Mitochondrial biogenesis: pharmacological approaches. Curr Pharm Des. 2014;20:5507-9 pubmed
    ..antioxidant producer exert a crucial role within the cell mediating processes such as apoptosis, detoxification, Ca2+ buffering, etc. This pivotal role makes mitochondria a potential target to treat a great variety of diseases...
  25. Shah S, Akhtar M, Hassan M, Akhtar M, Paudel Y, Najmi A. EGFR tyrosine kinase inhibition decreases cardiac remodeling and SERCA2a/NCX1 depletion in streptozotocin induced cardiomyopathy in C57/BL6 mice. Life Sci. 2018;210:29-39 pubmed publisher
    ..Decreased sarcoplasmic endoplasmic reticulum Ca2 + ATPase2a (SERCA2a) and sodium‑calcium exchanger-1 (NCX1) protein depletion after gefitinib administration ..
  26. Jemaà M, Fezai M, Bissinger R, Lang F. Methods Employed in Cytofluorometric Assessment of Eryptosis, the Suicidal Erythrocyte Death. Cell Physiol Biochem. 2017;43:431-444 pubmed publisher
    ..Signalling involved in the regulation of eryptosis includes Ca2+ entry, ceramide, caspases, calpain, p38 kinase, protein kinase C, Janus-activated kinase 3, casein kinase 1α, ..
  27. Nicoll R, Malenka R. Expression mechanisms underlying NMDA receptor-dependent long-term potentiation. Ann N Y Acad Sci. 1999;868:515-25 pubmed
    ..region of the hippocampus, as well as in many other areas of the CNS, its induction requires a rise in postsynaptic Ca2+ via activation of NMDA receptors. What happens after the rise in postsynaptic Ca2+ is less clear...
  28. Li X, Anishkin A, Liu H, van Rossum D, Chintapalli S, Sassic J, et al. Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate. J Gen Physiol. 2015;146:357-74 pubmed publisher
    Phosphatidylinositol 4,5-bisphosphate (PIP2) regulates Shaker K+ channels and voltage-gated Ca2+ channels in a bimodal fashion by inhibiting voltage activation while stabilizing open channels...
  29. Pellico J, Ruiz Cabello J, Herranz F. Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis. J Vis Exp. 2016;: pubmed publisher
    ..The use of this molecule leads a bisphosphonate moiety towards the outside of the nanoparticle that provides Ca2+ binding properties in vitro and selective accumulation in vivo in the atheroma plaque...
  30. Liu N, Yang Y, Ge L, Liu M, Colecraft H, Liu X. Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels. elife. 2017;6: pubmed publisher
    ..Meanwhile, CMI provides a new paradigm to develop CaV1 inhibitors, the therapeutic potential of which is implied by computational modeling of CaV1.3 dysregulations related to Parkinson's disease. ..
  31. Chen Y, Chen Y, Chiu W, Chen H, Shen M. STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion. Sci Rep. 2017;7:11523 pubmed publisher
    ..This study uncovers SOCE-mediated Ca2+ microdomain that is the molecular basis for Ca2+ sensitivity controlling podosome formation. ..
  32. Li C, Wang M, Wu X, Chen D, Lv H, Shen J, et al. THI1, a Thiamine Thiazole Synthase, Interacts with Ca2+-Dependent Protein Kinase CPK33 and Modulates the S-Type Anion Channels and Stomatal Closure in Arabidopsis. Plant Physiol. 2016;170:1090-104 pubmed publisher
    ..Together, our data reveal a novel regulatory role of thiamine thiazole synthase to kinase activity in guard cell signaling. ..
  33. Fokina A, Chechenova M, Karginov A, Ter Avanesyan M, Agaphonov M. Genetic Evidence for the Role of the Vacuole in Supplying Secretory Organelles with Ca2+ in Hansenula polymorpha. PLoS ONE. 2015;10:e0145915 pubmed publisher
    Processes taking place in the secretory organelles require Ca2+ and Mn2+, which in yeast are supplied by the Pmr1 ion pump...
  34. Ousingsawat J, Cabrita I, Wanitchakool P, Sirianant L, Krautwald S, Linkermann A, et al. Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis. Cell Mol Life Sci. 2017;74:173-181 pubmed publisher
    ..However, the knockdown of ANO6 or inhibitors of ANO6 did not inhibit necroptotic cell death. The present data demonstrate the activation of ANO6 during necroptosis, which, however, is not essential for cell death. ..
  35. Kalbe B, Schlimm M, Mohrhardt J, Scholz P, Jansen F, Hatt H, et al. Helional induces Ca2+ decrease and serotonin secretion of QGP-1 cells via a PKG-mediated pathway. J Mol Endocrinol. 2016;57:201-10 pubmed publisher
    ..Taken together, our results demonstrate that luminal odorants can be detected by specific ORs in QGP-1 cells and thus cause the directed release of serotonin and a PKG-dependent decrease in intracellular Ca(2.) ..
  36. Alonso M, Rodríguez Prados M, Navas Navarro P, Rojo Ruiz J, Garcia Sancho J. Using aequorin probes to measure Ca2+ in intracellular organelles. Cell Calcium. 2017;64:3-11 pubmed publisher
    ..GAP is robustly expressed in transgenic flies and mice, where it has proven to be a suitable Ca2+ indicator for monitoring physiological Ca2+ signaling ex vivo and in vivo. ..
  37. Wei Y, Wang Y, Wang Y, Bai L. Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model. Cell Physiol Biochem. 2017;42:319-332 pubmed publisher
    ..Autophagy is regulated by cytosolic Ca2+ activity and may thus be modified by the Ca2+ permeable transient receptor potential channel vanilloid 5 (TRPV5)...
  38. Rodríguez V, Rivoira M, Guizzardi S, Tolosa de Talamoni N. Naringin prevents the inhibition of intestinal Ca2+ absorption induced by a fructose rich diet. Arch Biochem Biophys. 2017;636:1-10 pubmed publisher
    ..Since NAR prevents the oxidative/nitrosative stress and inflammation, it might be a drug to avoid alteration in the intestinal Ca2+ absorption caused by FRD. ..
  39. Durant A, Celis Salgado M, Ezatollahpour S, Yan N, Arnott S, Donini A. Ca2+ levels in Daphnia hemolymph may explain occurrences of daphniid species along recent Ca gradients in Canadian soft-water lakes. Comp Biochem Physiol A Mol Integr Physiol. 2018;218:8-15 pubmed publisher
  40. Zsolnay V, Fill M, Gillespie D. Sarcoplasmic Reticulum Ca2+ Release Uses a Cascading Network of Intra-SR and Channel Countercurrents. Biophys J. 2018;114:462-473 pubmed publisher
    ..This multifactorial network of countercurrents allows Ca2+ release to be remarkably robust. ..
  41. Degand I, Catty P, Talla E, Thines Sempoux D, de Kerchove d Exaerde A, Goffeau A, et al. Rabbit sarcoplasmic reticulum Ca(2+)-ATPase replaces yeast PMC1 and PMR1 Ca(2+)-ATPases for cell viability and calcineurin-dependent regulation of calcium tolerance. Mol Microbiol. 1999;31:545-56 pubmed
    ..Saccharomyces cerevisiae, the Golgi PMR1 Ca(2+)-ATPase and the vacuole PMC1 Ca(2+)-ATPase function together in Ca2+ sequestration and Ca2+ tolerance...
  42. Hill S, Donegan R, Nguyen E, Desai T, Lieberman R. Molecular Details of Olfactomedin Domains Provide Pathway to Structure-Function Studies. PLoS ONE. 2015;10:e0130888 pubmed publisher
    ..features seen in OLFs such as the disulfide bond formed by N- and C- terminal cysteines, the sequestered Ca2+ ion within the propeller central hydrophilic cavity, and a key loop-stabilizing cation-Ï€ interaction on the ..
  43. Song M, Lee Z, Kim H. Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1. Exp Mol Med. 2015;47:e199 pubmed publisher
    Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells...
  44. Velmurugan G, Huang H, Sun H, Candela J, Jaiswal M, Beaman K, et al. Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production. Sci Signal. 2015;8:ra128 pubmed publisher
  45. Sá F, Lima Leopoldo A, Jacobsen B, Ferron A, Estevam W, Campos D, et al. Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling. Arq Bras Cardiol. 2015;105:588-96 pubmed publisher
    ..Obesity resistance promoted specific changes in the contraction phase without changes in the relaxation phase. This mild abnormality may be related to intracellular Ca2+ handling.
  46. Terentyev D, Hamilton S. Regulation of sarcoplasmic reticulum Ca2+ release by serine-threonine phosphatases in the heart. J Mol Cell Cardiol. 2016;101:156-164 pubmed publisher
    ..Here we review evidence in support of regulation of RyR2-mediated SR Ca2+ release by serine-threonine phosphatases and the role and mechanisms of dysregulation of phosphatases in various disease states. ..
  47. Astegno A, Bonza M, Vallone R, La Verde V, D Onofrio M, Luoni L, et al. Arabidopsis calmodulin-like protein CML36 is a calcium (Ca2+) sensor that interacts with the plasma membrane Ca2+-ATPase isoform ACA8 and stimulates its activity. J Biol Chem. 2017;292:15049-15061 pubmed publisher
    ..Collectively, our results support a role for CML36 as a Ca2+ sensor that binds to and modulates ACA8, uncovering a possible involvement of the CML protein family in the modulation of plant-autoinhibited Ca2+ pumps. ..
  48. Walker M, Gurev V, Rice J, Greenstein J, Winslow R. Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue. PLoS Comput Biol. 2017;13:e1005783 pubmed publisher
    ..Such events have been attributed to perturbed Ca2+ handling in cardiac myocytes leading to spontaneous Ca2+ release and delayed afterdepolarizations (DADs)...
  49. Huang S, Sjöblom B, Sauer Eriksson A, Jonsson B. Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant. Biochemistry. 2002;41:7628-35 pubmed
    Substitution of Pro for Thr199 in the active site of human carbonic anhydrase II (HCA II)(1) reduces its catalytic efficiency about 3000-fold...
  50. Martino N, Reshkin S, Ciani E, Dell Aquila M. Calcium-sensing receptor-mediated osteogenic and early-stage neurogenic differentiation in umbilical cord matrix mesenchymal stem cells from a large animal model. PLoS ONE. 2014;9:e111533 pubmed publisher;8 µm in diameter) and small (<8 µm) equine UCM-MSC lines were cultured in medium with high calcium (Ca2+) concentration ([Ca2+]o; 2.87 mM) and dose-response effects of AMG641 (0...
  51. Kim W, Park J, Park J, Choi D, Park Y. Purification and Characterization of a Fucoidanase (FNase S) from a Marine Bacterium Sphingomonas paucimobilis PF-1. Mar Drugs. 2015;13:4398-417 pubmed publisher
    ..FNase S activity was enhanced by Mn2+ and Na+ (115.7% and 131.2%), but it was inhibited by Ca2+, K+, Ba2+, Cu2+ (96%, 83.7%, 84.3%, and 89.3%, respectively), each at 1 mM...
  52. Dragoni S, Reforgiato M, Zuccolo E, Poletto V, Lodola F, Ruffinatti F, et al. Dysregulation of VEGF-induced proangiogenic Ca2+ oscillations in primary myelofibrosis-derived endothelial colony-forming cells. Exp Hematol. 2015;43:1019-1030.e3 pubmed publisher
    ..These results may explain the modest effect of anti-VEGF therapies in PMF. ..
  53. Wang N, Liu R, Liu Y, Zhang R, He L. Sinomenine potentiates P815 cell degranulation via upregulation of Ca2+ mobilization through the Lyn/PLCγ/IP3R pathway. Int J Immunopathol Pharmacol. 2016;29:676-683 pubmed
  54. Zhu Y, Uradu H, Majeed Z, Cooper R. Optogenetic stimulation of Drosophila heart rate at different temperatures and Ca2+ concentrations. Physiol Rep. 2016;4: pubmed publisher
    ..XXL substantially increased heart rate in all conditions. We have developed a system that can be instrumental in characterizing the physiology of optogenetically controlled cardiac function with an intact heart. ..
  55. Benoy A, Dasgupta A, Sajikumar S. Hippocampal area CA2: an emerging modulatory gateway in the hippocampal circuit. Exp Brain Res. 2018;236:919-931 pubmed publisher
    ..While social memory had long been attributed to be a function of the hippocampus, it is only of late that the area CA2 of the hippocampus was demarcated as essential for social memory formation...
  56. Sheng L, Leshchyns ka I, Sytnyk V. Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation. Cereb Cortex. 2019;29:1439-1459 pubmed publisher
    ..NCAM2 overexpression induces an increase in the frequency of submembrane Ca2+ spikes localized in individual dendritic protrusions and promotes propagation of submembrane Ca2+ spikes over ..
  57. Albrecht C, McVey J, Elliott J, Sardini A, Kasza I, Mumford A, et al. A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome. Blood. 2005;106:542-9 pubmed
    ..Overexpression of wild-type ABCA1 in SS lymphocytes complemented the Ca2+-dependent PS exposure at the cell surface...
  58. He D, Lu Y, Hu H, Zhang J, Qin B, Wang Y, et al. The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation. Int J Mol Sci. 2015;16:16313-29 pubmed publisher
    ..Moreover, TGF-β-dependent Wnt11 knockdown and L-type Ca2+ channel blocker could greatly reverse EMT progression and osteochondral differentiation in PRECs...
  59. Guo S, Wang T, Jia L, Li D, Shen Y, Xu D, et al. TRAM-34 attenuates hypoxia induced pulmonary artery smooth muscle cell proliferation. Eur Rev Med Pharmacol Sci. 2015;19:3515-21 pubmed
    ..The intermediate-conductance Ca2+-activated K+ channel (Kca3...
  60. Zammit A, Ezzati A, Zimmerman M, Lipton R, Lipton M, Katz M. Roles of hippocampal subfields in verbal and visual episodic memory. Behav Brain Res. 2017;317:157-162 pubmed publisher
    ..3T MRI brain scanning with subsequent automatic measurement of the hemispheric hippocampal subfield volumes (CA1, CA2-CA3, CA4-dente gyrus, presubiculum, and subiculum)...
  61. Tan Y, Gao D, Li L, Wei H, Wang J, Liu Q. [Relationships between H2O2 metabolism and Ca2+ transport in dormancy-breaking process of nectarine floral buds]. Ying Yong Sheng Tai Xue Bao. 2015;26:425-9 pubmed
    ..high temperature, hydrogen cyanamide and TDZ) on H2O2 metabolism were determined, and impacts of H2O2 on Ca2+ transport were tested using non-invasive micro-test technique...
  62. Sun R, Yang Y, Ran X, Yang T. Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1. PLoS ONE. 2016;11:e0158223 pubmed publisher
    ..Using LAD2 cells with the human high-affinity IgE receptor and Ca2+ release activation channel (CRAC), we demonstrated that Aptamer Y1 blocked IgE-mediated ?-hexosaminidase release ..
  63. Qian H, Patriarchi T, Price J, Matt L, Lee B, Nieves Cintrón M, et al. Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons. Sci Signal. 2017;10: pubmed publisher
    ..2 and enhancement of its activity by the β2-adrenergic receptor (β2AR)-cAMP-PKA cascade. Thus, there is an unexpected dichotomy in the control of Cav1.2 by PKA in cardiomyocytes and hippocampal neurons. ..
  64. Zebardast Roodi F, Aminzadeh S, Farrokhi N, Karkhane A, Haghbeen K. Cohnella amylopullulanases: Biochemical characterization of two recombinant thermophilic enzymes. PLoS ONE. 2017;12:e0175013 pubmed publisher
    ..Enzyme activities for both proteins were improved in the availability of Mn2+, Ba2+, Ca2+, and Mg2+ and reduced in the presence of Fe2+, Li2+, Na2+, Triton X100 and urea...
  65. Neef S, Mann C, Zwenger A, Dybkova N, Maier L. Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability. Basic Res Cardiol. 2017;112:45 pubmed publisher
    ..Further research is necessary towards clinical use in cardiac disease. ..
  66. Cousins E, Goldfarb D, Yan F, Roques J, Darr D, Johnson G, et al. Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling. Mol Cancer Res. 2018;16:333-344 pubmed publisher
    ..kinases, and dose-response MIB/MS profiling revealed glycogen synthase kinase 3 alpha and beta (GSK3α and β) and Ca2+/calmodulin-dependent protein kinase II delta and gamma (CAMKIIδ and γ) as the most potently inhibited...
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    Altered expression of carbonic anhydrase (CA) II is associated with human carcinogenesis. We analysed CA II protein expression in 89 patients with pseudomyxoma peritonei (PMP) and correlated its association against survival...