Gene Symbol: C8orf44-SGK3
Description: C8orf44-SGK3 readthrough
Alias: serine/threonine-protein kinase Sgk3, cytokine-independent survival kinase, serum/glucocorticoid-regulated kinase 3
Tessier M, Woodgett J. Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3. J Biol Chem. 2006;281:23978-89 pubmed
Slagsvold T, Marchese A, Brech A, Stenmark H. CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. EMBO J. 2006;25:3738-49 pubmed
..Taken together, these results reveal a critical function of CISK in specifically attenuating ubiquitin-dependent degradation of CXCR4, and provide a mechanistic link between the PI 3-kinase pathway and CXCR4 stability. ..
Sjoblom T, Jones S, Wood L, Parsons D, Lin J, Barber T, et al
. The consensus coding sequences of human breast and colorectal cancers. Science. 2006;314:268-74 pubmed
..These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology. ..
Greenman C, Stephens P, Smith R, Dalgliesh G, Hunter C, Bignell G, et al
. Patterns of somatic mutation in human cancer genomes. Nature. 2007;446:153-8 pubmed
..Systematic sequencing of cancer genomes therefore reveals the evolutionary diversity of cancers and implicates a larger repertoire of cancer genes than previously anticipated. ..
Bruhn M, Pearson R, Hannan R, Sheppard K. Second AKT: the rise of SGK in cancer signalling. Growth Factors. 2010;28:394-408 pubmed publisher
..Here, we will review the current state of knowledge on the regulation of the SGKs and their role in normal cell physiology and transformation with a particular focus on SGK3. ..
Kobayashi T, Deak M, Morrice N, Cohen P. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J. 1999;344 Pt 1:189-97 pubmed
..Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs. ..
Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, et al
. Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1. Genomics. 1999;62:95-7 pubmed
..By radiation hybrid mapping, the SGKL gene was located to human chromosome 8q12. 1-q13.1 between markers D8S510 and D8S1797. ..
Gamper N, Fillon S, Feng Y, Friedrich B, Lang P, Henke G, et al
. K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Pflugers Arch. 2002;445:60-6 pubmed
..The present observations thus reveal a powerful stimulating effect of all three isoforms of SGK on K(+) channels. Those effects may participate in regulation of epithelial transport, cell proliferation, and neuromuscular excitability. ..
Loffing J, Flores S, Staub O. Sgk kinases and their role in epithelial transport. Annu Rev Physiol. 2006;68:461-90 pubmed
..In this review we first discuss the molecular, cellular, and regulatory aspects of Sgk1 and its paralogs. We then discuss its roles in the physiology and pathophysiology of epithelial ion transport. ..