C7

Summary

Gene Symbol: C7
Description: complement C7
Alias: complement component C7, complement component 7
Species: human
Products:     C7

Top Publications

  1. Zhang P, Fu L, Liu H, Huda N, Zhu X, Han D, et al. Effects of inosine 5'-monophosphate supplementation in high fishmeal and high soybean diets on growth, immune-related gene expression in gibel carp (Carassius auratus gibelio var. CAS Ⅲ), and its challenge against Aeromonas hydrophila infection. Fish Shellfish Immunol. 2019;86:913-921 pubmed publisher
    ..related genes (intelectin, major histocompatibility complex class II β (MHC II β), Complement 3 (C3), Complement component C7-1 (ccC7), lysozyme C, Interleukin 1β (IL-1β), Tumor necrosis factor α1 (TNF-α1), Transforming growth ..
  2. Jiang T, Shi L, Chen J, Wei L, Li M, Hu Y, et al. Screening and identification of potential protein biomarkers for evaluating the efficacy of intensive therapy in pulmonary tuberculosis. Biochem Biophys Res Commun. 2018;503:2263-2270 pubmed publisher
    ..Significant differences in complement component C7 (CO7), apolipoprotein A-IV (APOA4), apolipoprotein C-II (APOC2), and angiotensinogen (ANGT) were found by ..
  3. Choi N, Hwang H, Ji E, Park G, Lee J, Lee H, et al. Direct analysis of site-specific N-glycopeptides of serological proteins in dried blood spot samples. Anal Bioanal Chem. 2017;409:4971-4981 pubmed publisher
    ..from 16 glycoproteins in the DBS samples, from immunoglobulin gamma 1 (IgG-1, 10 mg/mL) down to complement component C7 (50 μg/mL)...
  4. Wang S, Gao Y, Shu C, Xu T. Characterization and evolutionary analysis of duplicated C7 in miiuy croaker. Fish Shellfish Immunol. 2015;45:672-9 pubmed publisher
    ..The complement component C7 participates in the cytolytic phase of complement activation through a series of polymerization reactions ..
  5. Dinu V, Miller P, Zhao H. Evidence for association between multiple complement pathway genes and AMD. Genet Epidemiol. 2007;31:224-37 pubmed
    ..use the genotype data from a recently published AMD genome wide association study to identify two additional genes, C7 and MBL2, as potentially associated with subtypes of AMD...
  6. Zhong L, Li H, Li Z, Shi B, Wang P, Wang C, et al. C7 genotype of the donor may predict early bacterial infection after liver transplantation. Sci Rep. 2016;6:24121 pubmed publisher
    ..Using expression quantitative trait loci (eQTL) analysis, we found that the C7 rs6876739 CC genotypes and mannan-binding lectin (MBL2) gene polymorphisms of liver donors were significantly ..
  7. Gonzalez S, Martinez Borra J, Lopez Larrea C. Cloning and characterization of human complement component C7 promoter. Genes Immun. 2003;4:54-9 pubmed
    To study the transcriptional regulation of the human complement component C7, a 1 kb promoter fragment was cloned and the transcription start site was determined...
  8. Naughton M, Walport M, Wurzner R, Carter M, Alexander G, Goldman J, et al. Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humans. Eur J Immunol. 1996;26:2108-12 pubmed
    Many cells types can produce complement component C7, although the major site of C7 synthesis is unknown...
  9. Nurnberger W, Pietsch H, Seger R, Bufon T, Wahn V. Familial deficiency of the seventh component of complement associated with recurrent meningococcal infections. Eur J Pediatr. 1989;148:758-60 pubmed
    ..11-year-old girl suffering from recurrent meningitis with a complete absence of the seventh component of complement (C7). Diagnosis was established by haemolytic titration and western blotting...

More Information

Publications49

  1. Kallio S, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari P, et al. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Hum Mol Genet. 2009;18:1670-83 pubmed publisher
    ..73 (P = 0.000003) in the combined data set. The identified relatively rare risk haplotype contains C7 (complement component 7), an important player of the innate immune system...
  2. Wang L, Shao C, Xu W, Zhou Q, Wang N, Chen S. Proteome profiling reveals immune responses in Japanese flounder (Paralichthys olivaceus) infected with Edwardsiella tarda by iTRAQ analysis. Fish Shellfish Immunol. 2017;66:325-333 pubmed publisher
    ..Among the differentially expressed proteins, those involved in mediating complement cascade (e.g. complement component C7, C8, C9, complement factor H, complement factor Bf/C2) and mineral absorption (e.g...
  3. Debard A, Lamy B, Monneret G, Mira J, Pachot A, Kleijer M, et al. FcgammaRIIIb and complement component C7 codeficiency in a patient with recurrence of fulminant meningococcal septic shock. Clin Infect Dis. 2005;40:1679-83 pubmed
    ..We report the recurrence of fulminant meningococcal disease in a complement component C7-deficient patient...
  4. Sonnen A, Henneke P. Structural biology of the membrane attack complex. Subcell Biochem. 2014;80:83-116 pubmed publisher
    ..which leads to the formation of the membrane attack complex (MAC) composed of complement components C5b, C6, C7, C8 and C9...
  5. Hofsteenge J, Blommers M, Hess D, Furmanek A, Miroshnichenko O. The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues. J Biol Chem. 1999;274:32786-94 pubmed
    ..C-mannosylation, and to learn more about its mechanism, the terminal components of the human complement system (C6, C7, C8,and C9), which contain multiple and complex recognition motifs, were examined...
  6. Klegeris A, Bissonnette C, Dorovini Zis K, McGeer P. Expression of complement messenger RNAs by human endothelial cells. Brain Res. 2000;871:1-6 pubmed
    ..cells and HUVEC expressed detectable levels of complement gene mRNAs for the C1q B-chain, C1r, C1s, C2, C3, C4, C5, C7, C8 gamma-subunit and C9. In addition to C6 mRNA, C1q and C9 were not detected in ECV304 cells...
  7. Lian L, Ching A, Chong Z, Chua K. Complement components 2 and 7 (C2 and C7) gene polymorphisms are not major risk factors for SLE susceptibility in the Malaysian population. Rheumatol Int. 2012;32:3665-8 pubmed publisher
    ..This study examined the association of C2 and C7 genetic polymorphisms with the susceptibility to SLE based on two separate cohorts of patient and control samples ..
  8. Fernie B, Hobart M. Complement C7 deficiency: seven further molecular defects and their associated marker haplotypes. Hum Genet. 1998;103:513-9 pubmed
    Seven further molecular bases of C7 deficiency are described. All these new molecular defects involve single-nucleotide events, deletions and substitutions, some of which alter splice sites, and others codons...
  9. Thai C, Ogata R. Complement components C5 and C7: recombinant factor I modules of C7 bind to the C345C domain of C5. J Immunol. 2004;173:4547-52 pubmed
    Studies reported over 30 years ago revealed that latent, nonactivated C5 binds specifically and reversibly to C6 and C7. These reversible reactions are distinct from the essentially nonreversible associations with activated C5b that occur ..
  10. Oka R, Sasagawa T, Ninomiya I, Miwa K, Tanii H, Saijoh K. Reduction in the local expression of complement component 6 (C6) and 7 (C7) mRNAs in oesophageal carcinoma. Eur J Cancer. 2001;37:1158-65 pubmed
    Differential displays of tumour/normal pair specimens of human oesophagus identified complement component 7 (C7) as being enhanced in normal tissues, but remarkably reduced in carcinoma tissues...
  11. Coto E, Martinez Naves E, Dominguez O, DiScipio R, Urra J, Lopez Larrea C. DNA polymorphisms and linkage relationship of the human complement component C6, C7, and C9 genes. Immunogenetics. 1991;33:184-7 pubmed
    In this report we describe the linkage between genes encoding human complement components C6, C7, and C9. Polymorphisms have been described at the DNA level for the C7 and C9 genes...
  12. Reinartz J, Hansch G, Kramer M. Complement component C7 is a plasminogen-binding protein. J Immunol. 1995;154:844-50 pubmed
    ..Among the terminal complement components C5b6, C7, C8, and C9, the nonenzymatic component C7 is a plasminogen-binding protein...
  13. Shi H, Williams J, Guo L, Stampoulis D, Francesca Cordeiro M, Moss S. Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. Apoptosis. 2015;20:433-43 pubmed publisher
    ..Our observations provide new insight into the potential role of the complement system in photoreceptor loss, with implications for the molecular aetiology of retinal disease. ..
  14. Ying L, Zhang F, Pan X, Chen K, Zhang N, Jin J, et al. Complement component 7 (C7), a potential tumor suppressor, is correlated with tumor progression and prognosis. Oncotarget. 2016;7:86536-86546 pubmed publisher
    ..In the current study, the alteration was validated and complement component 7 (C7), located on 5p13.1, was identified...
  15. Egan L, Orren A, Doherty J, Wurzner R, McCarthy C. Hereditary deficiency of the seventh component of complement and recurrent meningococcal infection: investigations of an Irish family using a novel haemolytic screening assay for complement activity and C7 M/N allotyping. Epidemiol Infect. 1994;113:275-81 pubmed
    ..deficiency and the 2 affected brothers were found to be completely deficient in the seventh component of complement (C7). Enzyme-linked immunosorbent assay for C7 revealed lower than normal levels in the remaining brother and parents...
  16. Hallström T, Siegel C, Morgelin M, Kraiczy P, Skerka C, Zipfel P. CspA from Borrelia burgdorferi inhibits the terminal complement pathway. MBio. 2013;4: pubmed publisher
    ..Borrelial CspA binds the human terminal complement components C7 and C9 and blocks assembly and membrane insertion of the terminal complement complex (TCC)...
  17. Thai C, Ogata R. Recombinant C345C and factor I modules of complement components C5 and C7 inhibit C7 incorporation into the complement membrane attack complex. J Immunol. 2005;174:6227-32 pubmed
    Complement component C5 binds to components C6 and C7 in reversible reactions that are distinct from the essentially nonreversible associations that form during assembly of the complement membrane attack complex (MAC)...
  18. Hobart M, Fernie B, DiScipio R, Lachmann P. A physical map of the C6 and C7 complement component gene region on chromosome 5p13. Hum Mol Genet. 1993;2:1035-6 pubmed
  19. Gancz D, Donin N, Fishelson Z. Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death. Mol Immunol. 2009;47:310-7 pubmed publisher
    ..Our results demonstrate that complement C5b-9 induce a JNK/Bid-dependent and JNK-independent necrotic cell death. Both JNK1 and JNK2 have cytotoxic potential, however JNK2 is the primary signal transducer. ..
  20. Thomas A, Orren A, Connaughton J, Feighery C, Morgan B, Roberts A. Characterization of a large genomic deletion in four Irish families with C7 deficiency. Mol Immunol. 2012;50:57-9 pubmed publisher
    Inherited deficiency of the seventh complement component (C7) is associated with increased susceptibility to Neisseria meningitidis infections. The disease is rare in most Western countries...
  21. Seol H, Lee S, Song J, Rhee J, Singh S, Chang S, et al. Complement proteins C7 and CFH control the stemness of liver cancer cells via LSF-1. Cancer Lett. 2016;372:24-35 pubmed publisher
    ..Interestingly, we found significant upregulation of the complement proteins (p = 1.60 × 10(-18)), including C7 and CFH. Further studies revealed that C7 and CFH are required to maintain stemness in liver cancer cells...
  22. Tschopp J, Chonn A, Hertig S, French L. Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9. J Immunol. 1993;151:2159-65 pubmed
    ..we have examined the binding interactions between [125I]clusterin and the isolated components of the complex, C5b-6, C7, C8, and C9 and vitronectin...
  23. Bossi F, Rizzi L, Bulla R, Debeus A, Tripodo C, Picotti P, et al. C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. Blood. 2009;113:3640-8 pubmed publisher
    We describe a novel localization of C7 as a membrane-bound molecule on endothelial cells (ECs)...
  24. Muller Eberhard H. Molecular organization and function of the complement system. Annu Rev Biochem. 1988;57:321-47 pubmed
  25. Yan W, Che L, Jiang J, Yang F, Duan Q, Song H, et al. Depletion of complement system immunity in patients with myocardial infarction. Mol Med Rep. 2016;14:5350-5356 pubmed publisher
    ..05), whereas the mRNA levels of C1s, C7, C8? and C9 were the lowest in this group (P<0.05)...
  26. Kuijpers T, Nguyen M, Hopman C, Nieuwenhuys E, Dewald G, Lankester A, et al. Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease. Mol Immunol. 2010;47:671-7 pubmed publisher
    ..b>Complement component C7 is one of the five plasma proteins to form the MAC...
  27. Nishizaka H, Horiuchi T, Zhu Z, Fukumori Y, Volanakis J. Genetic bases of human complement C7 deficiency. J Immunol. 1996;157:4239-43 pubmed
    Complement C7 deficiency (C7D) is associated frequently with recurrent bacterial infections, especially meningitis caused by Neisseria meningitidis. We report in this work the molecular bases of C7D in two unrelated Japanese males...
  28. DiScipio R, Chakravarti D, Muller Eberhard H, Fey G. The structure of human complement component C7 and the C5b-7 complex. J Biol Chem. 1988;263:549-60 pubmed
    The molecular architecture of human complement component C7 was elucidated at several structural levels. The complete primary structure of C7 was derived from the cDNA sequence of clones isolated from a human liver library...
  29. Fernie B, Orren A, Sheehan G, Schlesinger M, Hobart M. Molecular bases of C7 deficiency: three different defects. J Immunol. 1997;159:1019-26 pubmed
    The molecular basis of C7 deficiency has been investigated in two Irish families and a number of Israeli families of Moroccan Sephardic Jewish origin...
  30. Fosbrink M, Cudrici C, Tegla C, Soloviova K, Ito T, Vlaicu S, et al. Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells. Exp Mol Pathol. 2009;86:87-94 pubmed publisher
    ..All these data together suggest that cell cycle induction by C5b-9 in AEC is RGC-32 dependent and this is in part through regulation of Akt and growth factor release. ..
  31. Mayilyan K. Complement genetics, deficiencies, and disease associations. Protein Cell. 2012;3:487-96 pubmed publisher
    ..early components of the alternative (factor D, properdin) and terminal pathways (from C3 onward components: C5, C6, C7, C8, C9) increase susceptibility to infections and their recurrence...
  32. Langeggen H, Pausa M, Johnson E, Casarsa C, Tedesco F. The endothelium is an extrahepatic site of synthesis of the seventh component of the complement system. Clin Exp Immunol. 2000;121:69-76 pubmed
    ..b>C7 was the only terminal component detected in measurable amounts in the cell supernatant...
  33. Phelan M, Thai C, Soares D, Ogata R, Barlow P, Bramham J. Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement. J Biol Chem. 2009;284:19637-49 pubmed publisher
    Factor I-like modules (FIMs) of complement proteins C6, C7, and factor I participate in protein-protein interactions critical to the progress of a complement-mediated immune response to infections and other trauma...
  34. Friduss S, Sadoff W, Hern A, Fivenson D. Fatal pyoderma gangrenosum in association with C7 deficiency. J Am Acad Dermatol. 1992;27:356-9 pubmed
    ..We describe an aggressive and ultimately fatal case of PG in a patient with a congenital C7 deficiency...
  35. Serna M, Giles J, Morgan B, Bubeck D. Structural basis of complement membrane attack complex formation. Nat Commun. 2016;7:10587 pubmed publisher
    ..Our results demonstrate how differences in symmetric and asymmetric components of the MAC underpin a molecular basis for pore formation and suggest a mechanism of action that extends beyond membrane penetration. ..
  36. DiScipio R. Formation and structure of the C5b-7 complex of the lytic pathway of complement. J Biol Chem. 1992;267:17087-94 pubmed
    ..intermediary complex, C5b-7, were studied with the aim of determining the interactive regions of C5, C6, and C7. The structure of human complement component C5 was elucidated by the application of limited proteolysis which ..
  37. Fernie B, Wurzner R, Orren A, Morgan B, Potter P, Platonov A, et al. Molecular bases of combined subtotal deficiencies of C6 and C7: their effects in combination with other C6 and C7 deficiencies. J Immunol. 1996;157:3648-57 pubmed
    Combined subtotal deficiency of C6 and C7, in which both proteins are expressed at very low levels, has been observed in homozygous form in two families...
  38. Hobart M, Fernie B, DiScipio R. Structure of the human C7 gene and comparison with the C6, C8A, C8B, and C9 genes. J Immunol. 1995;154:5188-94 pubmed
    ..We have determined the structure of the C7 gene, which is encoded by 18 exons whose sizes vary from 56 to 244 bp...
  39. Hadders M, Bubeck D, Roversi P, Hakobyan S, Forneris F, Morgan B, et al. Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Rep. 2012;1:200-7 pubmed publisher
    ..components associate through sideways alignment of the central MAC-perforin (MACPF) domains, resulting in a C5b6-C7-C8β-C8α-C9 arc...