Gene Symbol: C5orf66
Description: chromosome 5 open reading frame 66
Jia W, Zhang B, Matsuo K, Shin A, Xiang Y, Jee S, et al
. Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Nat Genet. 2013;45:191-6 pubmed publisher
..This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC. ..
Troyer J, Nelson G, Lautenberger J, Chinn L, McIntosh C, Johnson R, et al
. Genome-wide association study implicates PARD3B-based AIDS restriction. J Infect Dis. 2011;203:1491-502 pubmed publisher
..43, P = .025). These observations suggest a potential unsuspected pathway of host genetic influence on the dynamics of AIDS progression. ..
Pajewski N, Shrestha S, Quinn C, Parker S, Wiener H, Aissani B, et al
. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. Vaccine. 2012;30:4778-84 pubmed publisher
..032). Future studies will be required to replicate these findings in European Americans and to further elucidate the host genetic factors underlying variable immune response to AVA. ..
Zhang B, Jia W, Matsuda K, Kweon S, Matsuo K, Xiang Y, et al
. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Nat Genet. 2014;46:533-42 pubmed publisher
..11, 10q21.1 and 10q24.2. Furthermore, we replicated 22 previously reported CRC-associated loci. Our study provides insights into the genetic basis of CRC and suggests the involvement of new biological pathways. ..