C5L2

Summary

Gene Symbol: C5L2
Description: complement component 5a receptor 2
Alias: C5L2, GPF77, GPR77, C5a anaphylatoxin chemotactic receptor 2, C5a anaphylatoxin chemotactic receptor C5L2, G protein-coupled receptor 77, G protein-coupled receptor C5L2
Species: human
Products:     C5L2

Top Publications

  1. Chen N, Mirtsos C, Suh D, Lu Y, Lin W, McKerlie C, et al. C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature. 2007;446:203-7 pubmed
    ..C5L2 (also known as GPR77) is a relatively new GPCR thought to be a non-signalling receptor binding to C5a, on the basis of sequence ..
  2. Zheng Y, Xie X, Ma Y, Yang Y, Fu Z, Li X, et al. Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease. PLoS ONE. 2011;6:e20984 pubmed publisher
    b>C5L2 has been demonstrated to be a functional receptor of acylation-stimulating protein (ASP), which is a stimulator of triglyceride synthesis or glucose transport...
  3. Cui W, Simaan M, Laporte S, Lodge R, Cianflone K. C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation. Mol Immunol. 2009;46:3086-98 pubmed publisher
    b>C5L2, a G-protein-coupled receptor (GPCR), has been identified as an ASP (C3adesArg) and C5a receptor. Controversy exists regarding both ligand binding and functionality. ASP activation of C5L2 is proposed to regulate fat storage...
  4. Ohno M, Hirata T, Enomoto M, Araki T, Ishimaru H, Takahashi T. A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Mol Immunol. 2000;37:407-12 pubmed
    ..We report the cloning of a novel human gene encoding the putative orphan receptor, C5L2, belonging to a subfamily of C3a, C5a and formyl Met-Leu-Ph receptors that are related to the chemokine receptor ..
  5. Scola A, Johswich K, Morgan B, Klos A, Monk P. The human complement fragment receptor, C5L2, is a recycling decoy receptor. Mol Immunol. 2009;46:1149-62 pubmed publisher
    b>C5L2 is a 7 transmembrane domain receptor for complement fragment C5a that, unlike the classical C5a receptor, C5aR, does not couple to G proteins...
  6. Zheng Y, Xie X, Ma Y, Yang Y, Fu Z, Li X, et al. A novel polymorphism (901G > a) of C5L2 gene is associated with coronary artery disease in Chinese Han and Uyghur population. Lipids Health Dis. 2013;12:139 pubmed publisher
    b>C5L2, a G protein-coupled receptor (GPCR), has been demonstrated to be a ligand for acylation-stimulating protein (ASP)...
  7. Apostolidou E, Kambas K, Chrysanthopoulou A, Kourtzelis I, Speletas M, Ritis K, et al. Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever. Mol Biol Rep. 2012;39:5503-10 pubmed publisher
    ..The aim of this study was to investigate the genetic alterations and mRNA expression pattern of C5aR and C5L2 genes in neutrophils from attack-free FMF patients...
  8. Gerard N, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, et al. An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. J Biol Chem. 2005;280:39677-80 pubmed
    b>C5L2 is an enigmatic serpentine receptor that is co-expressed with the C5a receptor on many cells including polymorphonuclear neutrophils...
  9. Kalant D, MacLaren R, Cui W, Samanta R, Monk P, Laporte S, et al. C5L2 is a functional receptor for acylation-stimulating protein. J Biol Chem. 2005;280:23936-44 pubmed
    b>C5L2 binds acylation-stimulating protein (ASP) with high affinity and is expressed in ASP-responsive cells. Functionality of C5L2 has not yet been demonstrated...

More Information

Publications61

  1. Cui W, Lapointe M, Gauvreau D, Kalant D, Cianflone K. Recombinant C3adesArg/acylation stimulating protein (ASP) is highly bioactive: a critical evaluation of C5L2 binding and 3T3-L1 adipocyte activation. Mol Immunol. 2009;46:3207-17 pubmed publisher
    b>C5L2 is a recently identified receptor for C5a/C5adesArg, C3a and C3adesArg (ASP). C5a/C5adesArg bind with high affinity, with no identified activation...
  2. Raby A, Holst B, Davies J, Colmont C, Laumonnier Y, Coles B, et al. TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2. Eur J Immunol. 2011;41:2741-52 pubmed publisher
    ..Rather, TLRs targeted another C5a receptor, C5L2 (acting as a negative modulator of C5aR), by reducing C5L2 activity...
  3. Kalant D, Cain S, Maslowska M, Sniderman A, Cianflone K, Monk P. The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein. J Biol Chem. 2003;278:11123-9 pubmed
    The orphan receptor C5L2 has recently been described as a high affinity binding protein for complement fragments C5a and C3a that, unlike the previously described C5a receptor (CD88), couples only weakly to G(i)-like G proteins (Cain, S...
  4. Lee D, George S, Cheng R, Nguyen T, Liu Y, Brown M, et al. Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Res Mol Brain Res. 2001;86:13-22 pubmed
    We report the discovery and tissue distributions of four novel human genes, GPR61, GPR62, GPR63 and GPR77, all of which encode G protein-coupled receptors (GPCRs)...
  5. Johswich K, Martin M, Thalmann J, Rheinheimer C, Monk P, Klos A. Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines. J Biol Chem. 2006;281:39088-95 pubmed
    ..C5a and its degradation product C5a-des-Arg(74) also bind to the C5a receptor-like 2 (C5L2)...
  6. Scola A, Higginbottom A, Partridge L, Reid R, Woodruff T, Taylor S, et al. The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. J Biol Chem. 2007;282:3664-71 pubmed
    b>C5L2 is a new cellular receptor found to interact with the human anaphylatoxins complement factor C5a and its C-terminal cleavage product C5a des Arg...
  7. Huber Lang M, Sarma J, Rittirsch D, Schreiber H, Weiss M, Flierl M, et al. Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. J Immunol. 2005;174:1104-10 pubmed
    ..Recently, a second C5a receptor (C5L2) was detected on PMN without evidence of intracellular signaling...
  8. Bamberg C, Mackay C, Lee H, Zahra D, Jackson J, Lim Y, et al. The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. J Biol Chem. 2010;285:7633-44 pubmed publisher
    ..proinflammatory component of host defense that functions through two identified receptors, C5a receptor (C5aR) and C5L2. C5aR is a classical G protein-coupled receptor, whereas C5L2 is structurally homologous but deficient in G protein ..
  9. Cain S, Monk P. The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). J Biol Chem. 2002;277:7165-9 pubmed
    ..Here we report that the orphan receptor C5L2/gpr77, which shares 35% amino acid identity with CD88, binds C5a with high affinity but has a 10-fold higher affinity ..
  10. Johswich K, Martin M, Bleich A, Kracht M, Dittrich Breiholz O, Gessner J, et al. Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease. Inflamm Bowel Dis. 2009;15:1812-23 pubmed publisher
    ..Intriguingly, increases in C3a-receptor and C5L2 mRNA were dependent on C5aR...
  11. Farahbakhsh Farsi P, Djalali M, Koohdani F, Saboor Yaraghi A, Eshraghian M, Javanbakht M, et al. Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics. J Diabetes Metab Disord. 2014;13:1 pubmed publisher
    This randomized controlled trial investigated the role of omega-3 supplementation on C5L2 gene expression in type 2 diabetics...
  12. Zhang X, Liu Y, He T, Yang T, Wu J, Cianflone K, et al. Anaphylatoxin C5a induces inflammation and reduces insulin sensitivity by activating TLR4/NF-kB/PI3K signaling pathway in 3T3-L1 adipocytes. Biomed Pharmacother. 2018;103:955-964 pubmed publisher
    ..Levels of Omentin, Chemerin, Vaspin and Apelin 12 in supernatants of medium were examined using ELISA. C5L2, C5a receptor (C5aR), I kappa B (IkB), IkB kinase (IKK), insulin receptor substrate 1 (IRS-1), IRS-2, PI3 K, p-..
  13. Croker D, Halai R, Fairlie D, Cooper M. C5a, but not C5a-des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2. Immunol Cell Biol. 2013;91:625-33 pubmed publisher
    ..There are two known receptors for C5a: the C5a receptor (C5aR) and the C5a receptor like-2 (C5L2) receptor...
  14. Mehta G, Scheinman R, Holers V, Banda N. A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA. J Immunol. 2015;194:5446-54 pubmed publisher
    ..We first demonstrate that although C5aR2 or C5L2 (GPR77) plays no role in CAIA, C5aR1 contributes to pathogenesis...
  15. Chmilewsky F, About I, Cooper L, Chung S. C5L2 Silencing in Human Pulp Fibroblasts Enhances Nerve Outgrowth Under Lipoteichoic Acid Stimulation. J Endod. 2018;44:1396-1401 pubmed publisher
    ..Our data further showed a negative regulation of this brain-derived neurotropic factor secretion by C5L2, another C5aR. C5L2 was considered a nonfunctional receptor and thus has received much less attention than C5aR...
  16. David J, Barkema H, Guan L, De Buck J. Gene-expression profiling of calves 6 and 9 months after inoculation with Mycobacterium avium subspecies paratuberculosis. Vet Res. 2014;45:96 pubmed publisher
    ..neutrophil beta-defensin-9 like peptide (BNBD9-Like), S100 calcium binding protein A9 (s100A9) and G protein coupled receptor 77 (GPR77) or C5a anaphylatoxin chemotactic receptor (C5a2)...
  17. Spaan A, Henry T, van Rooijen W, Perret M, Badiou C, Aerts P, et al. The staphylococcal toxin Panton-Valentine Leukocidin targets human C5a receptors. Cell Host Microbe. 2013;13:584-594 pubmed publisher
    ..Here, we identify the human complement receptors C5aR and C5L2 as host targets of PVL, mediating both toxin binding and cytotoxicity...
  18. Raby A, Colmont C, Kift Morgan A, Köhl J, Eberl M, Fraser D, et al. Toll-Like Receptors 2 and 4 Are Potential Therapeutic Targets in Peritoneal Dialysis-Associated Fibrosis. J Am Soc Nephrol. 2017;28:461-478 pubmed publisher
    ..and complement in inflammation, we assessed the potential of peritoneal TLR2, TLR4 and C5a receptors, C5aR and C5L2, as therapeutic targets in PD-associated fibrosis...
  19. Poursharifi P, Lapointe M, Fisette A, Lu H, Roy C, Munkonda M, et al. C5aR and C5L2 act in concert to balance immunometabolism in adipose tissue. Mol Cell Endocrinol. 2014;382:325-333 pubmed publisher
    Recent studies suggested that the immunometabolic receptors; C5aR and C5L2, constitutively self-associate into homo-/heterodimers and that acylation stimulating protein (ASP/C3adesArg) or C5a treatment of adipocytes increased their ..
  20. Su S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisher
    ..Here, we demonstrate that two cell-surface molecules, CD10 and GPR77, specifically define a CAF subset correlated with chemoresistance and poor survival in multiple cohorts of breast ..
  21. Selle J, Asare Y, Köhncke J, Alampour Rajabi S, Shagdarsuren G, Klos A, et al. Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice. Thromb Haemost. 2015;114:848-58 pubmed publisher
    ..between high expressions of the second receptor for complement anaphylatoxin C5a, the C5a receptor-like 2 (C5L2, C5aR2), with high pro-inflammatory cytokine expression in advanced human atherosclerotic plaques...
  22. Wang R, Lu B, Gerard C, Gerard N. C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury. Am J Respir Cell Mol Biol. 2016;55:657-666 pubmed
    ..In the mouse model, however, the precise role of C5a and its receptors is unclear. C5L2, an enigmatic second receptor for C5a, has been characterized, and results have generated substantial debate ..
  23. Janesch P, Rouha H, Weber S, Malafa S, Gross K, Maierhofer B, et al. Selective sensitization of human neutrophils to LukGH mediated cytotoxicity by Staphylococcus aureus and IL-8. J Infect. 2017;74:473-483 pubmed publisher
    ..of PMNs to the other four leukocidins and reduced surface staining for their cognate receptors (CXCR1, CXCR2, C5aR, C5L2). Delta-toxin and peptidoglycan mimicked the effect of CS...
  24. A Verghese D, Demir M, Chun N, Fribourg M, Cravedi P, Llaudó I, et al. T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival. J Immunol. 2018;200:2186-2198 pubmed publisher
    C5aR2 (C5L2/gp77) is a seven-transmembrane spanning receptor that binds to C5a but lacks motifs essential for G protein coupling and associated signal transduction...
  25. Chmilewsky F, About I, Chung S. C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts. J Dent Res. 2017;96:92-99 pubmed publisher
    ..A second C5a receptor, C5L2, has also been cloned but has received much less attention because its interaction with the ligand induces no ..
  26. Roy C, Paglialunga S, Schaart G, Moonen Kornips E, Meex R, Phielix E, et al. Relationship of C5L2 receptor to skeletal muscle substrate utilization. PLoS ONE. 2013;8:e57494 pubmed publisher
    To investigate the role of Acylation Stimulating Protein (ASP) receptor C5L2 in skeletal muscle fatty acid accumulation and metabolism as well as insulin sensitivity in both mice and human models of diet-induced insulin resistance...
  27. Croker D, Halai R, Kaeslin G, Wende E, Fehlhaber B, Klos A, et al. C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and ?-arrestin recruitment. Immunol Cell Biol. 2014;92:631-9 pubmed publisher
    ..receptors: namely, the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly called C5L2)...
  28. Zheng Y, Xie X, Ma Y, Fu Z, Ma X, Yang Y, et al. Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China. Oncotarget. 2017;8:8590-8596 pubmed publisher
    C5aR-like receptor 2 (C5L2) has been identified as a receptor for the inflammatory factor Complement 5a (C5a) and acylation-stimulating protein (ASP). ASP binding to C5L2 leading to a net accumulation of TG stores and glucose transporter...
  29. Otto M, Hawlisch H, Monk P, Muller M, Klos A, Karp C, et al. C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. J Biol Chem. 2004;279:142-51 pubmed
    ..In addition to CD88, the seven-transmembrane receptor C5L2 has recently been found to provide high affinity binding sites for C5a and its desarginated form, C5adesArg74...
  30. Wu J, Jiao Z, Li R, Lu H, Zhang H, Cianflone K. Cholinergic activation suppresses palmitate-induced macrophage activation and improves acylation stimulating protein resistance in co-cultured adipocytes. Exp Biol Med (Maywood). 2017;242:961-973 pubmed publisher
    ..ASP signaling in adipocytes via its receptor C5L2 and signaling intermediates G?q, G?, phosphorylated protein kinase C-?, and protein kinase C-? were markedly ..
  31. Poursharifi P, Rezvani R, Gupta A, Lapointe M, Marceau P, Tchernof A, et al. Association of immune and metabolic receptors C5aR and C5L2 with adiposity in women. Mediators Inflamm. 2014;2014:413921 pubmed publisher
    Adipose tissue receptors C5aR and C5L2 and their heterodimerization/functionality and interaction with ligands C5a and acylation stimulating protein (ASP) have been evaluated in cell and rodent studies...
  32. Xu R, Lin F, Bao C, Huang H, Ji C, Wang S, et al. Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis. Cell Mol Immunol. 2016;13:103-9 pubmed publisher
    ..sepsis by inducing the functional impairment of neutrophils; however, the utility of C5a receptors (C5aRs; C5aR and C5L2) as biomarkers for the management of sepsis is uncertain...
  33. Mahajan S, Aalinkeel R, Parikh N, Jacob A, Cwiklinski K, Sandhu P, et al. Immunomodulatory Role of Complement Proteins in the Neuropathology Associated with Opiate Abuse and HIV-1 Co-Morbidity. Immunol Invest. 2017;46:816-832 pubmed publisher
    ..We examined the expression levels of C1q, SC5b-9, C5L2, C5aR, C3aR, and C9 key members of the complement cascade both in vivo in post mortem brain frontal cortex tissue ..
  34. Sabio Y García C, Yokobori N, Basile J, Balboa L, González A, López B, et al. C5aR contributes to the weak Th1 profile induced by an outbreak strain of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2017;103:16-23 pubmed publisher
    ..Herein we investigated whether C5a receptors, C5aR and C5L2, modulate the cytokine profiles induced by Mycobacterium tuberculosis (Mtb)...
  35. Alharbi K. Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population. Saudi Med J. 2015;36:544-8 pubmed publisher
    ..Two common variants PON1 (rs662) and C5L2 (rs149572881) were genotyped using polymerase chain reaction followed by restriction fragment length polymorphism ..
  36. van Werkhoven M, Damman J, Daha M, Krikke C, van Goor H, van Son W, et al. Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney. Mol Immunol. 2013;53:237-45 pubmed publisher
    ..The two receptors for C5a are C5a receptor (C5aR) and C5a-like-receptor-2 (C5L2)...
  37. Laursen N, Magnani F, Gottfredsen R, Petersen S, Andersen G. Structure, function and control of complement C5 and its proteolytic fragments. Curr Mol Med. 2012;12:1083-97 pubmed
    ..small anaphylatoxin C5a induces a variety of biological responses upon binding to the 7TM receptors C5aR and the C5L2, while the large C5b fragment nucleates formation of the membrane attack complex capable of killing susceptible ..
  38. Qu L, Jin X, Li L, Li S, Xie H. A novel mutation in C5L2 gene was associated with hyperlipidemia and retinitis pigmentosa in a Chinese family. Lipids Health Dis. 2014;13:75 pubmed publisher
    ..We aimed to identify the mutations in the C5L2 gene which was reported to be associated with hyperlipidemia in a Chinese family with (RP)...
  39. Pundir P, MacDonald C, Kulka M. The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production. J Immunol. 2015;195:2774-87 pubmed publisher
    ..Overall, this study reveals a novel role for C5aR2 in C5a-mediated activation of mast cells and demonstrates that C5aR2 ligation initiates a β-arrestin-2-, PI3K-, and ERK-dependent signaling pathway in these cells. ..
  40. Alharbi K, Khan I, Syed R. Circulating C5L2 gene polymorphism is associated with type 2 diabetes mellitus in Saudi population. Mol Biol Rep. 2013;40:6323-7 pubmed
    ..0 software for comparing T2DM subjects and healthy controls. In our study, genotypic distributions of C5L2 C698T polymorphism and allele frequency of patients and controls were found to be significant difference in the ..
  41. Lappas M, Woodruff T, Taylor S, Permezel M. Complement C5A regulates prolabor mediators in human placenta. Biol Reprod. 2012;86:190 pubmed publisher
    ..which exerts its biological effects through its receptors, C5AR (also known as CD88) and C5L2, official symbol GPR77. To date, there are few data available on the role of C5a and CD88 in human pregnancy, so the aim of this study ..
  42. Li R, Coulthard L, Wu M, Taylor S, Woodruff T. C5L2: a controversial receptor of complement anaphylatoxin, C5a. FASEB J. 2013;27:855-64 pubmed publisher
    ..In 2000, a second C5a receptor, C5L2 (previously known as GPR77), was discovered; yet, despite 12 yr of intensive research, its biological, or pathophysiological, function is ..
  43. Vijayan S, Asare Y, Grommes J, Soehnlein O, Lutgens E, Shagdarsuren G, et al. High expression of C5L2 correlates with high proinflammatory cytokine expression in advanced human atherosclerotic plaques. Am J Pathol. 2014;184:2123-33 pubmed publisher
    The complement anaphylatoxin C5a functions through its two receptors, C5aR (CD88) and C5a receptor-like 2 (C5L2). Their role in atherosclerosis is incompletely understood...
  44. Croker D, Monk P, Halai R, Kaeslin G, Schofield Z, Wu M, et al. Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. Immunol Cell Biol. 2016;94:787-95 pubmed publisher
    ..C5a, binds two seven transmembrane receptors, namely the C5a receptor 1 (C5aR1) and C5a receptor 2 (C5aR2, or C5L2). C5aR2 is a non-G-protein-signalling receptor whose biological role remains controversial...
  45. Martin I, Bohner A, Boor P, Shagdarsuren E, Raffetseder U, Lammert F, et al. Complement C5a receptors C5L2 and C5aR in renal fibrosis. Am J Physiol Renal Physiol. 2017;:ajprenal.00060.2017 pubmed publisher
    Complement factor C5a has two known receptors, C5aR mediating pro-inflammatory effects and C5L2, a potential C5a scavenger. We previously identified C5a/C5aR signaling as a potent profibrotic pathway in the kidney...
  46. Fonseca M, McGuire S, Counts S, Tenner A. Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology. J Neuroinflammation. 2013;10:25 pubmed publisher
    ..exerts its chemotactic and inflammatory functions through the CD88 receptor while the more recently discovered C5L2 receptor has been postulated to have an anti-inflammatory role...
  47. Hawksworth O, Li X, Coulthard L, Wolvetang E, Woodruff T. New concepts on the therapeutic control of complement anaphylatoxin receptors. Mol Immunol. 2017;89:36-43 pubmed publisher
    ..This review provides an update on the growing arsenal of drugs now available to target C5, and C5a and C3a receptor signaling, and discusses their utility in both clinical and pre-clinical development. ..
  48. Cao Q, McIsaac S, Stadnyk A. Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway. Am J Physiol Cell Physiol. 2012;302:C1731-40 pubmed publisher
    ..T84, HT29, and Caco2 cell lines all possessed mRNA and protein for C5aR and the decoy receptor C5L2. Polarized cells expressed the proteins on the apical cell membrane...
  49. Hao J, Wang C, Yuan J, Chen M, Zhao M. A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation. PLoS ONE. 2013;8:e66305 pubmed publisher
    ..The functional role of the second receptor of C5a, C5L2, remains unclear...
  50. Zheng Y, Xie X, Ma Y, Yang Y, Fu Z, Li X, et al. Relationship between type 2 diabetes mellitus and a novel polymorphism C698T in C5L2 in the Chinese Han population. Endocrine. 2012;41:296-301 pubmed publisher
    In a previous study, we reported a novel single nucleotide polymorphism (SNP) 698C>T (P233L) in the gene, C5L2. This gene has been demonstrated to encode a functional receptor of acylation-stimulating protein (ASP), a G-protein-coupled ..
  51. Zheng Y, Xie X, Ma Y, Yang Y, Fu Z, Li X, et al. S323I polymorphism of the C5L2 gene was not identified in a Chinese population with familial combined hyperlipidemia or with type 2 diabetes. Genet Mol Res. 2011;10:3256-66 pubmed publisher
    b>C5L2, a G protein-coupled receptor, is known to be a functional receptor of acylation-stimulating protein, which is a stimulator of triglyceride synthesis and glucose transport...
  52. Karsten C, Wiese A, Mey F, Figge J, Woodruff T, Reuter T, et al. Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse. J Immunol. 2017;199:3234-3248 pubmed publisher
    The biological significance of C5a receptor [(C5aR)2/C5L2], a seven-transmembrane receptor binding C5a and C5adesArg, remains ill-defined...