C5AR1

Summary

Gene Symbol: C5AR1
Description: complement C5a receptor 1
Alias: C5A, C5AR, C5R1, CD88, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin receptor, C5a ligand, C5a-R, complement component 5 receptor 1, complement component 5a receptor 1
Species: human
Products:     C5AR1

Top Publications

  1. Farkas I, Takahashi M, Fukuda A, Yamamoto N, Akatsu H, Baranyi L, et al. Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease. J Immunol. 2003;170:5764-71 pubmed
    In our earlier results, we demonstrated that cells expressing the complement C5aR are vulnerable since abnormal activation of C5aR caused apoptosis of these cells...
  2. Nishiura H, Nonaka H, Revollo I, Semba U, Li Y, Ota Y, et al. Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase. Lab Invest. 2009;89:676-94 pubmed publisher
    ..or thapsigargin treatment, human HL-60 and AsPC-1 cells initiate de novo synthesis of the C5a receptor (C5aR) and generation of its ligand, the ribosomal protein S19 (RP S19) homodimer...
  3. Bamberg C, Mackay C, Lee H, Zahra D, Jackson J, Lim Y, et al. The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. J Biol Chem. 2010;285:7633-44 pubmed publisher
    ..C5a is a proinflammatory component of host defense that functions through two identified receptors, C5a receptor (C5aR) and C5L2...
  4. Apostolidou E, Kambas K, Chrysanthopoulou A, Kourtzelis I, Speletas M, Ritis K, et al. Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever. Mol Biol Rep. 2012;39:5503-10 pubmed publisher
    ..No mutations were observed in the two receptors' genes, while the genetic alteration observed in the C5aR1 gene was identified as N279 K polymorphic variant...
  5. Poursharifi P, Lapointe M, Pétrin D, Devost D, Gauvreau D, Hebert T, et al. C5L2 and C5aR interaction in adipocytes and macrophages: insights into adipoimmunology. Cell Signal. 2013;25:910-8 pubmed publisher
    Obesity is associated with inflammation characterized by increased infiltration of macrophages into adipose tissue. C5aR-like receptor 2 (C5L2) has been identified as a receptor for acylation-stimulating protein (ASP) and the inflammatory ..
  6. Gerard N, Gerard C. The chemotactic receptor for human C5a anaphylatoxin. Nature. 1991;349:614-7 pubmed
    ..receptors CR1 and CR3 are responsible for the phagocytic and adhesive properties of neutrophils, whereas the C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a...
  7. Werfel T, Zwirner J, Oppermann M, Sieber A, Begemann G, Drommer W, et al. CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin. J Immunol. 1996;157:1729-35 pubmed
    The expression of the C5aR (CD88) on human epidermal and dermal cells was studied with five anti-C5aR mAb directed to the N-terminal domain of the receptor. All mAb bound to suspended dermal CD117+ mast cells and to dermal CD14+ cells...
  8. Chen Z, Zhang X, Gonnella N, Pellas T, Boyar W, Ni F. Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin. J Biol Chem. 1998;273:10411-9 pubmed
    The functions of the C5a anaphylatoxin are expressed through its interaction with a cell-surface receptor with seven transmembrane helices...
  9. Nishiura H, Tokita K, Li Y, Harada K, Woodruff T, Taylor S, et al. The role of the ribosomal protein S19 C-terminus in Gi protein-dependent alternative activation of p38 MAP kinase via the C5a receptor in HMC-1 cells. Apoptosis. 2010;15:966-81 pubmed publisher
    We have demonstrated that an alternative C5a receptor (C5aR) ligand, the homodimer of ribosomal protein S19 (RP S19), contains a unique C-terminus (I(134)-H(145)) that is distinct from the moieties involved in the C5a-C5aR interaction...

More Information

Publications125 found, 100 shown here

  1. Shibuya Y, Shiokawa M, Nishiura H, Nishimura T, Nishino N, Okabe H, et al. Identification of receptor-binding sites of monocyte chemotactic S19 ribosomal protein dimer. Am J Pathol. 2001;159:2293-301 pubmed
    The S19 ribosomal protein (RP S19) cross-linked homo-dimer attracts monocyte migration by binding to C5a receptor on monocytes (H Nishiura, Y Shibuya, T Yamamoto, Laboratory Investigation, 1998, 78:1615-1623)...
  2. Nakano H, Moran T, Nakano K, Gerrish K, Bortner C, Cook D. Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells. J Immunol. 2015;194:3808-19 pubmed publisher
    ..CD11b(hi)Ly-6C(lo) tissue-resident and CD11b(hi)Ly-6C(hi) inflammatory moDCs, express the complement 5a receptor 1/CD88, whereas preDC-derived conventional DCs (cDCs), including CD103(+) and CD11b(hi) cDCs, express dipeptidyl peptidase-..
  3. Derer S, Cossham M, Rösner T, Kellner C, Beurskens F, Schwanbeck R, et al. A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells. J Immunol. 2015;195:5077-87 pubmed publisher
    ..Strong cell surface expression of C5a receptors was detected on PMN, whereas NK cells completely lacked expression...
  4. Natarajan N, Abbas Y, Bryant D, González Rosa J, Sharpe M, Uygur A, et al. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018;137:2152-2165 pubmed publisher
  5. Spaan A, Schiepers A, de Haas C, van Hooijdonk D, Badiou C, Contamin H, et al. Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors. J Immunol. 2015;195:1034-43 pubmed publisher
    ..PVL) and γ-hemolysin CB (HlgCB) target human phagocytes through interaction with the complement receptors C5aR1 and C5aR2...
  6. Abdelbaset Ismail A, Borkowska Rzeszotek S, Kubis E, Bujko K, Brzeźniakiewicz Janus K, Bolkun L, et al. Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. Leukemia. 2017;31:446-458 pubmed publisher
    ..This finding was supported by the detection of C3a and C5a receptors in cells from human malignant hematopoietic cell lines and patient blasts at the mRNA (reverse ..
  7. Zhang L, Bell B, Yu M, Chan C, Peachey N, Fung J, et al. Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis. J Leukoc Biol. 2016;99:447-54 pubmed publisher
    ..However, the precise role of the complement anaphylatoxin receptors (C3a and C5a receptors) in the pathogenesis of autoimmune uveitis remains elusive and controversial...
  8. Regal J, Strehlke M, Peterson J, Wing C, Parker J, Nieto N, et al. Role of IgM and angiotensin II Type I receptor autoantibodies in local complement activation in placental ischemia-induced hypertension in the rat. Mol Immunol. 2016;78:38-47 pubmed publisher
    ..demonstrated that inhibiting complement activation attenuated increased maternal blood pressure with C3a and C5a identified as the important products of complement activation...
  9. Thorenz A, Derlin K, Schröder C, Dressler L, Vijayan V, Pradhan P, et al. Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury-induced inflammation and fibrosis. Kidney Int. 2018;94:741-755 pubmed publisher
    ..Little is known about the roles of the C5aR1 and C5aR2 complement receptors in IRI...
  10. Fattahi F, Frydrych L, Bian G, Kalbitz M, Herron T, Malan E, et al. Role of complement C5a and histones in septic cardiomyopathy. Mol Immunol. 2018;102:32-41 pubmed publisher
    ..Activation of complement system results in generation of C5a which interacts with its receptors (C5aR1, C5aR2)...
  11. Thurman J, Nemenoff R. Never make assumptions: the complicated role of complement in urinary tract infections. Kidney Int. 2016;90:469-71 pubmed publisher
    ..demonstrates that blockade of signaling at one of the C5a receptors (C5a receptor 1 [C5aR1]) reduces renal fibrosis in a mouse model of urinary tract infection with Escherichia coli...
  12. Esen F, Orhun G, Ozcan P, Sentürk E, Küçükerden M, Giris M, et al. Neuroprotective effects of intravenous immunoglobulin are mediated through inhibition of complement activation and apoptosis in a rat model of sepsis. Intensive Care Med Exp. 2017;5:1 pubmed publisher
    ..IVIgG and IgGAM administration significantly reduced systemic complement activity and cerebral C5a and C5a receptor expression...
  13. Okojie A, Okobi O, Dar H, Malik H, Arif M, Rauf K, et al. Potential link between Complement 5a Receptor and mood disorders in mouse exposed to experimental malaria in utero. Niger J Physiol Sci. 2017;32:171-177 pubmed
    ..The complement 5a receptor (C5aR) is linked to several disease conditions...
  14. de Haan J, Bosch L, Borgman A, Bastemeijer M, Brans M, Van de Weg S, et al. Complement 5a Receptor deficiency does not influence adverse cardiac remodeling after pressure-overload in mice. Sci Rep. 2017;7:17045 pubmed publisher
    ..To test if C5aR is involved in adverse cardiac remodeling following pressure-overload, we induced transverse aortic constriction (..
  15. Pai M, Liu J, Hou Y, Yeh C. Soybean and Fish Oil Mixture With Different ω-6/ω-3 Polyunsaturated Fatty Acid Ratios Modulates Dextran Sulfate Sodium-Induced Changes in Small Intestinal Intraepithelial γδT-Lymphocyte Expression in Mice. JPEN J Parenter Enteral Nutr. 2016;40:383-91 pubmed publisher
    ..messenger RNA (mRNA) expressions of Reg IIIγ, keratinocyte growth factor (KGF), and complement 5a receptor (C5aR) by IEL γδT cells. Fish oil administration enhanced the proportion of small intestinal IEL γδT cells...
  16. Kalbitz M, Grailer J, Fattahi F, Jajou L, Herron T, Campbell K, et al. Role of extracellular histones in the cardiomyopathy of sepsis. FASEB J. 2015;29:2185-93 pubmed publisher
    ..Main findings revealed that extracellular histones appearing in septic plasma required C5a receptors, polymorphonuclear leukocytes (PMNs), and the Nacht-, LRR-, and PYD-domains-containing protein 3 (NLRP3) ..
  17. Grailer J, Fattahi F, Dick R, Zetoune F, Ward P. Cutting edge: critical role for C5aRs in the development of septic lymphopenia in mice. J Immunol. 2015;194:868-72 pubmed publisher
    ..and puncture resulted in splenocyte apoptosis and significant lymphopenia after 3 d, which was not observed in C5aR1(-/-) or C5aR2(-/-) mice...
  18. Mathern D, Heeger P. Molecules Great and Small: The Complement System. Clin J Am Soc Nephrol. 2015;10:1636-50 pubmed publisher
    ..activation yields production of the anaphylatoxins C3a and C5a, which bind to their respective receptors (C3aR and C5aR) on both partners to augment effector T-cell proliferation and survival, while simultaneously inhibiting regulatory ..
  19. Kwak J, Laskowski J, Li H, McSharry M, Sippel T, Bullock B, et al. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018;78:143-156 pubmed publisher
    ..Similarly, antagonists of the C3a or C5a receptors inhibited tumor growth...
  20. Denny K, Coulthard L, Jeanes A, Lisgo S, Simmons D, Callaway L, et al. C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. J Immunol. 2013;190:3493-9 pubmed publisher
    ..C5aR was also found to be expressed in the neuroepithelium of early human embryos. Ablation of the C5ar1 gene or the administration of a specific C5aR peptide antagonist to folic acid-deficient pregnant mice resulted in ..
  21. Kumar V, Lee J, Clark R, Woodruff T. Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Sci Rep. 2018;8:8101 pubmed publisher
    PMX53 and PMX205 are cyclic hexapeptide inhibitors of complement C5a receptors (C5aR1), that are widely used to study C5aR1 pathobiology in mouse models of disease...
  22. Yoshikawa M. Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects. Peptides. 2015;72:208-25 pubmed publisher
    ..which interact with receptors for endogenous bioactive peptides such as opioids, neurotensin, complements C3a and C5a, oxytocin, and formyl peptides etc...
  23. Wang C, Cao S, Zhang D, Li H, Kijlstra A, Yang P. Increased Complement 3a Receptor is Associated with Behcet's disease and Vogt-Koyanagi-Harada disease. Sci Rep. 2017;7:15579 pubmed publisher
    ..Complement 3a receptor (C3aR) and complement 5a receptor (C5aR) have been reported to be involved in T cell mediated autoimmune disease...
  24. Zhang J, Kew R. Identification of a region in the vitamin D-binding protein that mediates its C5a chemotactic cofactor function. J Biol Chem. 2004;279:53282-7 pubmed
    ..is a multifunctional plasma protein that can significantly enhance the leukocyte chemotactic activity to C5a and C5a des-Arg...
  25. Johswich K, Martin M, Thalmann J, Rheinheimer C, Monk P, Klos A. Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines. J Biol Chem. 2006;281:39088-95 pubmed
    ..pro-inflammatory anaphylatoxins C3a and C5a are generated, which interact with the C3a receptor and C5a receptor (CD88), respectively. C5a and its degradation product C5a-des-Arg(74) also bind to the C5a receptor-like 2 (C5L2)...
  26. Ruan C, Ma Y, Ge Q, Li Y, Zhu L, Zhang Y, et al. Complement-mediated inhibition of adiponectin regulates perivascular inflammation and vascular injury in hypertension. FASEB J. 2017;31:1120-1129 pubmed publisher
    ..Mechanistically, complement 5a (C5a)-induced TNF-? secretion from macrophages is required for inhibiting APN expression in adipocytes...
  27. Van Roey G, Vanison C, Wu J, Huang J, Suh L, Carter R, et al. Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2017;140:89-100.e2 pubmed publisher
    ..Tissue homogenates were analyzed for complement activation products (ELISA-C5b-9, C4d, activated C1, and C5a) and major complement-fixing antibodies (Luminex). Tissue sections were stained for C5b-9, C4d, and laminin...
  28. Cunnion K, Krishna N, Pallera H, Pineros Fernandez A, Rivera M, Hair P, et al. Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds. PLoS ONE. 2017;12:e0170500 pubmed publisher
    ..The CS was found to be activated early in the diabetic wounds as demonstrated by increased anaphylatoxin C5a in wound fluid and C3-fragment deposition by immunostaining...
  29. Zhang T, Garstka M, Li K. The Controversial C5a Receptor C5aR2: Its Role in Health and Disease. J Immunol Res. 2017;2017:8193932 pubmed publisher
    After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des-arginine form...
  30. Wertenbruch S, Drescher H, Grossarth V, Kroy D, Giebeler A, Erschfeld S, et al. The Anti-Microbial Peptide LL-37/CRAMP Is Elevated in Patients with Liver Diseases and Acts as a Protective Factor during Mouse Liver Injury. Digestion. 2015;91:307-17 pubmed publisher
    ..Patients with liver diseases were analyzed for LL-37/CRAMP, human beta-defensin-2 (hBD2), and complement 5a (C5a) serum levels...
  31. Doerner S, Reis E, Leung E, Ko J, Heaney J, Berger N, et al. High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity. Mol Cancer Res. 2016;14:953-965 pubmed
    ..The complement fragment C5a acts as the trigger for inflammation and intestinal tumorigenesis...
  32. Liewert I, Ehrig K, Alban S. Effects of fucoidans and heparin on reactions of neutrophils induced by IL-8 and C5a. Carbohydr Polym. 2017;165:462-469 pubmed publisher
    ..Potential targets may be the chemokine interleukin 8 (IL-8) and the anaphylatoxin C5a, as they are closely linked to inflammatory processes...
  33. Liu X, Wang X, Li R, Jia S, Sun P, Zhao M, et al. Recent progress in the understanding of complement activation and its role in tumor growth and anti-tumor therapy. Biomed Pharmacother. 2017;91:446-456 pubmed publisher
    ..Membrane attack complex (MAC) and anti-tumor anaphylatoxins like C5a have significant effects on promoting tumor, such as upregulation of oncogenic growth factors, activation of ..
  34. Bujko K, Rzeszotek S, Hoehlig K, Yan J, Vater A, Ratajczak M. Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization. Stem Cell Rev. 2017;13:793-800 pubmed publisher
    ..on the exact mechanisms and the molecules involved, we performed studies in mice that do not express the receptor C5aR, which binds the C5 cleavage fragments, C5a and C5adesArg...
  35. Yamamoto T. Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes. Pathol Int. 2007;57:1-11 pubmed
    ..the major phagocytic leukocytes, migrate to inflammatory sites by sensing chemoattractants such as anaphylatoxin C5a with membrane receptors such as C5a receptor...
  36. Carrigan S, Pink D, Stadnyk A. Neutrophil transepithelial migration in response to the chemoattractant fMLP but not C5a is phospholipase D-dependent and related to the use of CD11b/CD18. J Leukoc Biol. 2007;82:1575-84 pubmed
    ..to fMLP is appreciated to be CD11b/CD18 integrin (Mac-1)-dependent, while we recently reported that migration to C5a is Mac-1-independent...
  37. Wong Baeza C, Tescucano A, Astudillo H, Reséndiz A, Landa C, España L, et al. Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus. J Immunol Res. 2015;2015:369462 pubmed publisher
    ..Mice with the lupus-like disease had increased serum concentrations of proinflammatory cytokines, C3a and C5a; they also had more TLR-4-expressing splenocytes, a higher expression of genes associated with TRIF-dependent TLR-4-..
  38. Jozawa H, Kabir M, Zako T, Maeda M, Chiba K, Kuroda Y. Amorphous protein aggregation monitored using fluorescence self-quenching. FEBS Lett. 2016;590:3501-3509 pubmed publisher
    ..variants where three types of Solubility Controlling Peptide tags (SCP tags) made of five serines (C5S), alanines (C5A) or aspartic acids (C5D) were added to the C terminus of C2G...
  39. Ding R, Xu G, Feng Y, Zou L, Chao W. Lipopeptide Pam3Cys4 Synergizes N-Formyl-Met-Leu-Phe (Fmlp)-Induced Calcium Transients in Mouse Neutrophils. Shock. 2017;: pubmed publisher
    ..the fMLP-induced [Ca]i transients, and had no effect on the host component keratinocyte-derived cytokine (KC)- or C5a-induced calcium flux...
  40. Dick J, Gan P, Kitching A, Holdsworth S. The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis. PLoS ONE. 2018;13:e0190655 pubmed publisher
    ..While signalling by complement anaphylatoxin C5a though the C5a receptor is important in this disease, the role of the anaphylatoxin C3a signalling via the C3a ..
  41. Ren W, Liu Y, Wang X, Piao C, Ma Y, Qiu S, et al. The Complement C3a-C3aR Axis Promotes Development of Thoracic Aortic Dissection via Regulation of MMP2 Expression. J Immunol. 2018;200:1829-1838 pubmed publisher
    ..However, the role of the complement system in TAD is unknown. We found that plasma levels of C3a, C4a, and C5a were significantly increased in patients with TAD...
  42. Mansour M, Karmilowicz M, Hawrylik S, Nalcerio B, Angilly J, Conklyn M, et al. Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells. Am J Physiol. 1996;270:L1002-7 pubmed
    ..The purified preparation was active in vitro and in vivo as determined by its ability to prime human basophils to release leukotriene C4 in the presence of C5a and to induce airway eosinophilia in naive guinea pigs.
  43. Hasegawa K, Tamari M, Shao C, Shimizu M, Takahashi N, Mao X, et al. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hum Genet. 2004;115:295-301 pubmed
    ..single nucleotide polymorphisms (SNPs) in C3, C5, the C3a receptor gene (C3AR1), and the C5a receptor gene (C5R1) and performed association studies in the Japanese population...
  44. Zhu Y, Dai B, Li Y, Peng H. C5a and toll-like receptor 4 crosstalk in retinal pigment epithelial cells. Mol Vis. 2015;21:1122-9 pubmed
    ..Blocking experiments showed that the effect of C5a on cytokine production was mediated via C5aR. ERK1/2, but not JNK or p38, were involved in the production of IL-6 and IL-8...
  45. Bertolaccini M, Contento G, Lennen R, Sanna G, Blower P, Ma M, et al. Complement inhibition by hydroxychloroquine prevents placental and fetal brain abnormalities in antiphospholipid syndrome. J Autoimmun. 2016;75:30-38 pubmed publisher
    ..HCQ prevented complement activation in vivo and in vitro. Complement C5a levels in serum samples from APS patients and APS-mice were lower after treatment with HCQ while the antibodies ..
  46. Bergdolt S, Kovtun A, Hägele Y, Liedert A, Schinke T, Amling M, et al. Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. PLoS ONE. 2017;12:e0179512 pubmed publisher
    The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts...
  47. Kalbasi Anaraki P, Patecki M, Larmann J, Tkachuk S, Jurk K, Haller H, et al. Urokinase receptor mediates osteogenic differentiation of mesenchymal stem cells and vascular calcification via the complement C5a receptor. Stem Cells Dev. 2014;23:352-62 pubmed publisher
    ..We investigated a role for the complement receptor C5aR in these processes...
  48. Conroy A, Gélvez M, Hawkes M, Rajwans N, Tran V, Liles W, et al. Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study. Int J Infect Dis. 2015;40:45-53 pubmed publisher
    ..Ang-1 levels were lower and angptl3, sKDR, sEng, sICAM-1, CRP, CXCL10/IP-10, IL-18 binding protein, CHI3L1, C5a and Factor D levels were increased in dengue compared to HC...
  49. Kronbichler A, Kerschbaum J, Gründlinger G, Leierer J, Mayer G, Rudnicki M. Evaluation and validation of biomarkers in granulomatosis with polyangiitis and microscopic polyangiitis. Nephrol Dial Transplant. 2016;31:930-6 pubmed publisher
    ..0 was used to generate a predictive biomarker panel. The review indicated abundant expression of sC5bC9, C3a, C5a and monocyte chemotactic protein (MCP)-1 in urine, whereas granulocyte macrophage colony-stimulating factor, C-..
  50. Jiang J, Zheng Z, Wang K, Wang J, He Y, Wang E, et al. Adjuvant Immune Enhancement of Subunit Vaccine Encoding pSCPI of Streptococcus iniae in Channel Catfish (Ictalurus punctatus). Int J Mol Sci. 2015;16:28001-13 pubmed publisher
    ..iniae) infections in recent years, some of them severe. C5a peptidase is an important virulent factor of S. iniae...
  51. Vaivoda R, Vaine C, Boerstler C, Galloway K, Christmas P. CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a. J Immunol Res. 2015;2015:250456 pubmed publisher
    ..There was no significant difference in the chemotactic response to LTB4, but the response to complement component C5a increased 1.9-2.25-fold in knockout cells compared to wild-type (P < 0.01)...
  52. Chen J, Kaitsuka T, Fujino R, Araki K, Tomizawa K, Yamamoto T. Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice. Neurosci Lett. 2016;629:221-226 pubmed publisher
    ..function as cross-linked RP S19 oligomers which function as a ligand of the complement 5a (C5a) receptor (CD88)...
  53. Yuan B, Fu F, Huang S, Lin C, Yang G, Ma K, et al. C5a/C5aR Pathway Plays a Vital Role in Brain Inflammatory Injury via Initiating Fgl-2 in Intracerebral Hemorrhage. Mol Neurobiol. 2017;54:6187-6197 pubmed publisher
    ..In the current study, C57BL/6J mice were injected with autologous whole blood. C5a/C5aR levels, microglia infiltration, inflammatory cytokine, and fibrinogen-like protein 2 (Fgl-2) expression in the ..
  54. Laumonnier Y, Karsten C, Köhl J. Novel insights into the expression pattern of anaphylatoxin receptors in mice and men. Mol Immunol. 2017;89:44-58 pubmed publisher
    ..e. C3a receptor (C3aR), C5a receptor 1 (C5aR1) and C5a receptor 2 (C5aR2), although the latter lacks important sequence motifs for G protein-coupling...
  55. Kusmartsev S, Dominguez Gutierrez P, Canales B, Bird V, Vieweg J, Khan S. Calcium Oxalate Stone Fragment and Crystal Phagocytosis by Human Macrophages. J Urol. 2016;195:1143-51 pubmed publisher
    ..chemokines chemokine ligand (CCL)2, CCL3, interleukin (IL)-1 receptor antagonist (IL-1ra), complement component C5/C5a and IL-8. Response patterns to stone and crystal material depended on macrophage phenotype and activation status...
  56. van der Maten E, de Bont C, De Groot R, de Jonge M, Langereis J, van der Flier M. Alternative pathway regulation by factor H modulates Streptococcus pneumoniae induced proinflammatory cytokine responses by decreasing C5a receptor crosstalk. Cytokine. 2016;88:281-286 pubmed publisher
    ..Crosstalk between complement C5a receptor (C5aR) and other innate immune receptors is known to enhance the proinflammatory cytokine response...
  57. Sagar A, Dai W, Minot M, Lecover R, Varner J. Reduced order modeling and analysis of the human complement system. PLoS ONE. 2017;12:e0187373 pubmed publisher
    ..We estimated an ensemble of model parameters from in vitro dynamic measurements of the C3a and C5a complement proteins...
  58. Su S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisher
    ..NF-κB activation via p65 phosphorylation and acetylation, which is maintained by complement signaling via GPR77, a C5a receptor...
  59. Oksjoki R, Laine P, Helske S, Vehmaan Kreula P, Mäyränpää M, Gasque P, et al. Receptors for the anaphylatoxins C3a and C5a are expressed in human atherosclerotic coronary plaques. Atherosclerosis. 2007;195:90-9 pubmed
    ..Here we studied whether human coronary plaques express anaphylatoxin receptors C3aR and C5aR, i.e. whether they have the potential to respond to anaphylatoxins...
  60. Huber Lang M, Ignatius A, Brenner R. Role of Complement on Broken Surfaces After Trauma. Adv Exp Med Biol. 2015;865:43-55 pubmed publisher
    ..In addition, key complement components and the corresponding receptors (such as C3aR, C5aR) have been detected on "exposed surfaces" of the damaged regions...
  61. Yamamoto M, Tanaka H, Xin B, Nishikawa Y, Yamazaki K, Shimizu K, et al. Role of the BrafV637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice. Mol Carcinog. 2017;56:478-488 pubmed publisher
    ..and p19Arf as well as pro-survival/pro-proliferative cytokines/chemokines such as complement C5/C5a, ICAM-1, IL-1 receptor antagonist and CXCL9, suggesting that the BrafV637E mutation influences the expression of ..
  62. Ji M, Lu Y, Zhao C, Gao W, He F, Zhang J, et al. C5a Induces the Synthesis of IL-6 and TNF-? in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways. PLoS ONE. 2016;11:e0161867 pubmed publisher
    ..Besides C5b-9 complex, C5a is also a potent pro-inflammatory mediator and correlated to severity of various nephritic diseases...
  63. Yao S, Cao F, Chen J, Chen W, Fan R, Li G, et al. NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH. J Mol Neurosci. 2017;61:385-395 pubmed publisher
    ..As a result, complement 3a (C3a) and complement 5a (C5a) were upregulated during the ICH-induced neuroinflammation, and ablation of C3 attenuates ICH-induced IL-1? release...
  64. Martin I, Bohner A, Boor P, Shagdarsuren E, Raffetseder U, Lammert F, et al. Complement C5a receptors C5L2 and C5aR in renal fibrosis. Am J Physiol Renal Physiol. 2017;:ajprenal.00060.2017 pubmed publisher
    Complement factor C5a has two known receptors, C5aR mediating pro-inflammatory effects and C5L2, a potential C5a scavenger. We previously identified C5a/C5aR signaling as a potent profibrotic pathway in the kidney...
  65. Hu X, Li X, Hu C, Qin L, He R, Luo L, et al. Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses. Sci Rep. 2017;7:15207 pubmed publisher
    ..In this study, we assessed the contribution of C5a-C5aR to CD4+T cell immune responses in RSV-infected asthma mice...
  66. Noone D, Hebert D, Licht C. Pathogenesis and treatment of ANCA-associated vasculitis-a role for complement. Pediatr Nephrol. 2018;33:1-11 pubmed publisher
    ..Targeting the activation of neutrophils by the anaphylatoxin C5a may serve as an additional therapeutic strategy, however the results of clinical studies are awaited.
  67. Bao L, Gerard N, Eddy R, Shows T, Gerard C. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics. 1992;13:437-40 pubmed
    The genes encoding receptors for the chemotactic ligands C5a (C5AR) and FMLP (FPR) were mapped using a panel of somatic cell hybrids to chromosome 19...
  68. Fujita E, Farkas I, Campbell W, Baranyi L, Okada H, Okada N. Inactivation of C5a anaphylatoxin by a peptide that is complementary to a region of C5a. J Immunol. 2004;172:6382-7 pubmed
    ..Patch clamp electrophysiology experiments also showed the effectiveness of Pep-A in C5aR-expressing neuroblastoma cells...
  69. Matsumoto M, Narzinski K, Nikiforovich G, Baranski T. A comprehensive structure-function map of the intracellular surface of the human C5a receptor. II. Elucidation of G protein specificity determinants. J Biol Chem. 2007;282:3122-33 pubmed
    ..We have used a collection of 133 functional mutants of the C5a receptor obtained in a mutagenesis screen targeting the intracellular loops and the carboxyl terminus (Matsumoto, M...
  70. Sabio Y García C, Yokobori N, Basile J, Balboa L, González A, López B, et al. C5aR contributes to the weak Th1 profile induced by an outbreak strain of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2017;103:16-23 pubmed publisher
    ..Herein we investigated whether C5a receptors, C5aR and C5L2, modulate the cytokine profiles induced by Mycobacterium tuberculosis (Mtb)...
  71. Cockx M, Gouwy M, Ruytinx P, Lodewijckx I, van Hout A, Knoops S, et al. Monocytes from patients with Primary Ciliary Dyskinesia show enhanced inflammatory properties and produce higher levels of pro-inflammatory cytokines. Sci Rep. 2017;7:14657 pubmed publisher
    ..The receptor for C5a (C5aR) was upregulated in PCD, whereas expression levels of the leukocyte chemoattractant receptors CCR1, CCR2, CCR5, ..
  72. Kastl S, Speidl W, Kaun C, Rega G, Assadian A, Weiss T, et al. The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation. J Thromb Haemost. 2006;4:1790-7 pubmed
    ..Pertussis toxin or anti-C5aR/CD88 antibody completely abolished the effect of recombinant human C5a on PAI-1 production, suggesting a role of the C5a ..
  73. Cain S, Monk P. The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). J Biol Chem. 2002;277:7165-9 pubmed
    ..However, only a single receptor for C5a and C5adR(74), CD88, has been characterized to date...
  74. Contractor T, Kobayashi S, da Silva E, Clausen R, Chan C, Vosburgh E, et al. Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5. Oncotarget. 2016;7:30585-96 pubmed publisher
    ..Treatment with PMX53, a small molecule antagonist of C5aR1/CD88, the receptor for complement C5a, also reduced metastasis...
  75. Toomey C, Johnson L, Bowes Rickman C. Complement factor H in AMD: Bridging genetic associations and pathobiology. Prog Retin Eye Res. 2018;62:38-57 pubmed publisher
    ..We also review the literature on the role of other complement components in AMD pathobiologies, including C3a, C5a and the membrane attack complex (MAC), and on transgenic mouse models developed to interrogate in vivo the effects ..
  76. Yang Y, Wang C, Jin L, He F, Li C, Gao Q, et al. IgG4 anti-phospholipase A2 receptor might activate lectin and alternative complement pathway meanwhile in idiopathic membranous nephropathy: an inspiration from a cross-sectional study. Immunol Res. 2016;64:919-30 pubmed publisher
    ..Completed remission (CR) was a major clinical outcome. A series of complement ingredients (MASP-1/2, MBL, C3a, C5a, Factor B, Ba, Bb and C5b-9) were measured in the patients of bi-positivity and bi-negativity: (1) meta-analysis ..
  77. Kalbitz M, Fattahi F, Grailer J, Jajou L, Malan E, Zetoune F, et al. Complement-induced activation of the cardiac NLRP3 inflammasome in sepsis. FASEB J. 2016;30:3997-4006 pubmed
    ..CLP caused substantial increases in mRNAs for IL-1? and NLRP3 in CMs which are reduced in the absence of either C5aR1 or C5aR2. After CLP, NLRP3-/- mice showed reduced plasma levels of IL-1? and IL-6...
  78. Kaida T, Nitta H, Kitano Y, Yamamura K, Arima K, Izumi D, et al. C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA. Oncotarget. 2016;7:84798-84809 pubmed publisher
    Anaphylatoxin C5a is a strong chemoattractant of the complement system that binds the C5a receptor (C5aR). The expression of C5aR is associated with poor prognosis in several cancers...
  79. Veszeli N, Kőhalmi K, Kajdacsi E, Gulyás D, Temesszentandrási G, Cervenak L, et al. Complete kinetic follow-up of symptoms and complement parameters during a hereditary angioedema attack. Allergy. 2017;: pubmed publisher
    ..C1-INH concentration and functional activity (C1-INHc+f ), C1(q,r,s), C3, C4, C3a, C4a, C5a, and SC5b-9 levels were measured in blood samples obtained during the 96-hour observation period...
  80. Shushakova N, Tkachuk N, Dangers M, Tkachuk S, Park J, Zwirner J, et al. Urokinase-induced activation of the gp130/Tyk2/Stat3 pathway mediates a pro-inflammatory effect in human mesangial cells via expression of the anaphylatoxin C5a receptor. J Cell Sci. 2005;118:2743-53 pubmed
    ..via its specific receptor (uPAR, CD87), upregulated expression of the complement anaphylatoxin C5a receptor (C5aR, CD88), and modulates C5a-dependent functional responses...
  81. van Werkhoven M, Damman J, Daha M, Krikke C, van Goor H, van Son W, et al. Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney. Mol Immunol. 2013;53:237-45 pubmed publisher
    ..The two receptors for C5a are C5a receptor (C5aR) and C5a-like-receptor-2 (C5L2)...
  82. Cho H, Son Y, Kim S, Kim B, Eo S, Park Y, et al. 7?-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. PLoS ONE. 2017;12:e0173749 pubmed publisher
    ..Expression of C5a receptor was upregulated after stimulation with 7?OHChol, but not with 7K and 7?OHChol, and a specific antagonist ..
  83. Atanes P, Ruz Maldonado I, Pingitore A, Hawkes R, Liu B, Zhao M, et al. C3aR and C5aR1 act as key regulators of human and mouse β-cell function. Cell Mol Life Sci. 2018;75:715-726 pubmed publisher
    ..In this study we characterised islet expression of C3 and C5 complement components, and the impact of C3aR and C5aR1 activation on islet function and viability...
  84. Sengeløv H. Complement receptors in neutrophils. Crit Rev Immunol. 1995;15:107-31 pubmed
    ..A fifth complement receptor, C5aR, is constitutively present on the neutrophil plasma membrane...
  85. Wojta J, Kaun C, Zorn G, Ghannadan M, Hauswirth A, Sperr W, et al. C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils. Blood. 2002;100:517-23 pubmed
    ..When HMC-1 cells were incubated with pertussis toxin or anti-C5a receptor antibodies, the effect of rhC5a on PAI-1 production was completely abolished...
  86. Arumugam T, Woodruff T, Stocks S, Proctor L, Pollitt S, Shiels I, et al. Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. J Hepatol. 2004;40:934-41 pubmed
    ..This study investigated the efficacy of a small molecule C5a receptor (C5aR) antagonist against hepatic I/R injury...
  87. Skeie J, Fingert J, Russell S, Stone E, Mullins R. Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells. Invest Ophthalmol Vis Sci. 2010;51:5336-42 pubmed publisher
    ..AMD patients and controls were genotyped at SNPs in the C5R1 and C3AR1 genes. C5aR, but not C3aR, was detected in human choroid...
  88. Gutzmer R, Köther B, Zwirner J, Dijkstra D, Purwar R, Wittmann M, et al. Human plasmacytoid dendritic cells express receptors for anaphylatoxins C3a and C5a and are chemoattracted to C3a and C5a. J Invest Dermatol. 2006;126:2422-9 pubmed
    ..blood did not express the receptors for C3a and C5a, complement C3a receptor (C3aR) and complement C3a receptor (C5aR). If these pDC precursors were cultured with IL-3, the resultant immature pDC expressed both receptors...
  89. Matsumoto M, Narzinski K, Kiser P, Nikiforovich G, Baranski T. A comprehensive structure-function map of the intracellular surface of the human C5a receptor. I. Identification of critical residues. J Biol Chem. 2007;282:3105-21 pubmed
    ..To identify residues on the intracellular face of the human C5a receptor that are involved in G protein activation, we performed a genetic analysis of each of the three ..
  90. Tayman C, Tonbul A, Kahveci H, Uysal S, Koseoglu B, Tatli M, et al. C5a, a complement activation product, is a useful marker in predicting the severity of necrotizing enterocolitis. Tohoku J Exp Med. 2011;224:143-50 pubmed
    ..The complement activation product, C5a (anaphylatoxin) has been reported to be a contributing factor leading to mesenteric ischemia/reperfusion injury ..
  91. Shah T, Nejad J, Pallera H, Lattanzio F, Farhat R, Kumar P, et al. Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy. Pediatr Res. 2017;81:654-662 pubmed publisher
    ..The complement system plays a major role in the pathogenesis of ischemia-reperfusion injuries such as HIE. We have previously demonstrated that HT modulates complement activity in vitro...
  92. Esen F, Ozcan P, Tuzun E, Boone M. Mechanisms of action of intravenous immunoglobulin in septic encephalopathy. Rev Neurosci. 2017;: pubmed publisher
    ..Future animal model experiments performed with specific C5aR and NF-?B agonists/antagonists or C5aR-deficient mice might more robustly disclose the significance of these ..